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Ep 2790536 B1 (19) TZZ Z¥_T (11) EP 2 790 536 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: A24F 47/00 (2006.01) A61M 15/06 (2006.01) 28.06.2017 Bulletin 2017/26 A24B 15/16 (2006.01) A24D 1/18 (2006.01) (21) Application number: 12857581.8 (86) International application number: PCT/US2012/069214 (22) Date of filing: 12.12.2012 (87) International publication number: WO 2013/090410 (20.06.2013 Gazette 2013/25) (54) DEVICE AND METHOD FOR SIMULATING CHEMOSENSATION OF SMOKING VORRICHTUNG UND VERFAHREN ZUR SIMULATION DER GERUCHS- UND GESCHMACKSWAHRNEHMUNG DES RAUCHENS DISPOSITIF ET PROCÉDÉ DE SIMULATION DE LA CHIMIOSENSATION DE FUMER (84) Designated Contracting States: US-A- 5 167 242 US-A- 5 611 360 AL AT BE BG CH CY CZ DE DK EE ES FI FR GB US-A1- 2004 055 613 US-A1- 2007 298 090 GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR • C Orwa ET AL: "Styrax tonkinensis", Agroforestree Database:a tree reference and (30) Priority: 14.12.2011 US 201161570660 P selection guide version 4.0, 1 January 2009 24.05.2012 US 201261651184 P (2009-01-01), XP055189582, Retrieved from the 11.12.2012 US 201213710801 Internet: URL:http://www.worldagroforestry.org/treed (43) Date of publication of application: b2/AFTPDFS/Styrax_tonkinensis.PDF [retrieved 22.10.2014 Bulletin 2014/43 on 2015-05-18] • Anonymous: "Allyl isothiocyanate", Wikipedia, (73) Proprietor: Sentiens, LLC the free encyclopedia, 29 April 2015 (2015-04-29), Charlotte, North Carolina 28277 (US) XP055189584, Retrieved from the Internet: URL:http://en.wikipedia.org/wiki/Allyl_iso (72) Inventors: thiocyanate [retrieved on 2015-05-18] • VON BORSTEL, Reid • Anonymous: "Wasabi", Wikipedia, 14 May 2015 Potomac, Maryland 20854 (US) (2015-05-14), XP055189874, Retrieved from the • TAN, Dennis Internet: Weddington, North Carolina 28104 (US) URL:http://en.wikipedia.org/wiki/Wasabi • SIVERLING, John [retrieved on 2015-05-18] Matthews, North Carolina 28105 (US) • TALAVERA ET AL.: ’Nicotine activates the • TIMOKHINA, Inna S. chemosensory cation channel TRPA1.’ NATURE Potomac, Maryland 20854 (US) NEUROSCIENCE vol. 12, no. 10, October 2009, pages 1293 - 1299, XP055073299 (74) Representative: Sessford, Russell • VENKATACHALAM ET AL.: ’TRP Channels.’ Forresters IP LLP ANNU. REV. BIOCHEM. vol. 76, 2007, pages 387 Skygarden - 471, XP055073301 Erika-Mann-Strasse 11 • VRIENS JORIS ET AL: "Herbal Compounds and 80636 München (DE) Toxins Modulating TRP Channels", CURRENT NEUROPHARMACOLOGY, BENTHAM SCIENCE (56) References cited: PUBLISHERS, HILVERSUM, NL, vol. 6, no. 1, 1 WO-A1-2012/117935 WO-A2-2011/117755 March 2008 (2008-03-01), pages 79-96, CN-A- 102 266 125 US-A- 3 200 819 XP002556013, ISSN: 1570-159X Note: Within nine months of the publication of the mention of the grant of the European patent in the European Patent Bulletin, any person may give notice to the European Patent Office of opposition to that patent, in accordance with the Implementing Regulations. Notice of opposition shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention). EP 2 790 536 B1 Printed by Jouve, 75001 PARIS (FR) (Cont. next page) EP 2 790 536 B1 • CE RIERA ET AL: "Compounds from Sichuan and • SIDNEY A. SIMON ET AL: ’How irritating: the role Melegueta peppers activate, covalently and of TRPA1 in sensing cigarette smoke and non-covalently, TRPA1 and TRPV1 channels", aerogenic oxidants in the airways’ JOURNAL OF BRITISH JOURNAL OF PHARMACOLOGY, vol. CLINICAL INVESTIGATION vol. 110450, no. 8, 01 157, no. 8, 1 August 2009 (2009-08-01), pages July 2008, US, pages 987 - 9971409, XP055322926 1398-1409, XP055261188, BASINGSTOKE, DOI: 10.1172/JCI36111 ISSN: 0021-9738 HANTS; GB ISSN: 0007-1188, DOI: 10.1111/j.1476-5381.2009.00307.x • JOLAD S D ET AL: "Commercially processed dry ginger (Zingiber officinale): Composition and effects on LPS-stimulated PGE2 production", PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 66, no. 13, 1 July 2005 (2005-07-01), pages 1614-1635, XP004971548, ISSN: 0031-9422, DOI: 10.1016/J.PHYTOCHEM.2005.05.007 2 EP 2 790 536 B1 Description BACKGROUND 5 [0001] Smoking is prohibited in many locations where smokers may spend considerable time, including work places, restaurants, airplanes, and hospitals. In such settings, the experience of craving for cigarettes can cause significant discomfort and distraction. Nicotine absorption into the bloodstream and brain is a factor, but it is not the only or primary factor for relief of cigarette craving, as indicated, for example, by the failure of transdermal nicotine delivery patches or other nicotine replacement therapies to have a dramatic effect on smoking cessation success rates. Nicotine-free cig- 10 arettes can reduce cigarette craving symptoms, but they do not represent an alternative for use in environments where smoking is prohibited. It has been suggested that sensory effects of smoke inhalation, and to some extent, the simple motor effects of smoking behavior, may help to alleviate craving. [0002] Habituation to tactile and kinesthetic aspects of handling and smoking a cigarette contributes to reinforcement of smoking behavior, as do the organoleptic qualities of cigarette smoke, the taste and other sensations in the mouth, 15 throat and respiratory tract. Sensory aspects of smoking contribute to smoking behavior and relief of cigarette craving both through conditioned or learned association with nicotine delivery, but also through direct "hard-wired" autonomic and sensory-metabolic reflexes independent of nicotine entry into the brain. In particular, the characteristic airway sen- sation caused by inhaled tobacco smoke (sometimes referred to as "throat scratch," "throat impact" or "throat hit") is reported as a significant component of smoking satisfaction and especially of relief of acute cigarette craving. Isolated 20 reduction of throat sensations with local anesthetics reduce the relief of smoking craving induced by nicotine-containing cigarette smoke; conversely, maintenance of throat scratch while disabling olfaction and oral taste sensation with an anesthetic mouthwash can alleviate the negative affect associated with cigarette craving. The "throat scratch" can affect perceived taste qualities and more subtle throat and airway autonomic sensory nerve stimulation, which can have effects beyond taste sensations. The airway sensations of inhaled cigarette smoke involve activation of receptors on sensory 25 nerve endings by nicotine, other smoke components, as well as high temperatures of smoke. [0003] An aerosol of citric acid or ascorbic acid has been reported to reduce cigarette craving symptoms via irritation of the throat. However, the airway sensations elicited by aerosols of these nonvolatile acids were accompanied by the sour taste sensations not associated with smoking tobacco and required generation of an aqueous aerosol by using a device that did not resemble a cigarette. 30 [0004] Inhalation of vapor from black pepper oil from a plastic cigarette-like device has been reported to reduce cigarette smoke craving. Some cigarette substitutes that simulate some features of the smoking experience, while acting as non- pyrolytic nicotine delivery devices, have also been described. Other such substitutes have been described which intend to reduce cigarette craving without delivering nicotine. Electrical devices for creating a vapor simulating tobacco smoke have also been described which typically involve heating a solution of nicotine and flavor agents dissolved in propylene 35 glycol or glycerol to produce a smoke-like aerosol that delivers flavorings and nicotine in solvent droplets. Some vaporizing devices are shaped like a cigarette, including a battery, vaporizing chamber and a reservoir for liquid, which can be held in a porous substrate. [0005] However, the devices described above fail to provide a non-combustible, non-electric cigarette substitute that adequately mimics tactile, kinesthetic, organoleptic and/or chemosensory qualities of cigarettes and cigarette smoking 40 for relieving negative affect or mood associated with cigarette craving at times when smoking is not possible or for use in supporting smoking cessation. Prior art document CN102266125 discloses an electronic cigarette comprising a car- tridge padded with porous cotton and an e-juice absorbed thereon comprising under others ethanol, Borneo camphor, Rosmarini officinalis, menthol crystal, benzoin and clove 45 BRIEF SUMMARY [0006] Aspects of the present invention are recited by the appended claims. According to the invention, a device for simulating chemosensation of smoking includes an outer layer, a porous medium and a chemesthetic agent. The porous medium is disposed within the outer layer. The chemesthetic agent is disposed within the porous medium and includes 50 a Zingiberaceae extract that activates a TRP (transient receptor potential) channel. The Zingiberaceae extract includes Aframomum Meleguata extract. In another embodiment, a device for simulating chemosensation of smoking includes an outer layer, a porous medium and a chemesthetic agent. The porous medium is disposed within the outer layer. The chemesthetic agent is disposed within the porous medium and includes a Brassicaceae extract that activates a TRP channel. 55 [0007] In another embodiment, a device for simulating chemosensation of smoking includes an outer layer, a porous medium and a chemesthetic agent. The porous medium is disposed within the outer layer. The chemesthetic agent is disposed within the porous medium and includes a Lamiaceae extract that activates a TRP channel. [0008] In another embodiment, a device for simulating chemosensation of smoking includes an outer layer, a porous 3 EP 2 790 536 B1 medium and a chemesthetic agent. The porous medium is disposed within the outer layer. The chemesthetic agent is disposed within the porous medium and includes a Toddalioideae extract that activates a TRP channel. [0009] In another embodiment, a device for simulating chemosensation of smoking includes an outer layer, a porous medium and a chemesthetic agent. The porous medium is disposed within the outer layer.
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