The Future of Genomic Medicine IX Thursday, March 3 and Friday, March 4, 2016 • Scripps Institution of Oceanography • La Jolla, California Presented in partnership with AAAS/Science Translational Medicine Course Introduction Conference Highlights • Voice of the patient represented Course Overview throughout the conference In collaboration with AAAS/Science Translational Medicine we invite you to • Renowned faculty representing the another exciting two day program on Thursday, March 3 and Friday, March country’s leading institutions • Multiple panel discussion segments 4, 2016 in beautiful San Diego, California. The 2016 program will again be with ample question and answer time with faculty held at Scripps Institution of Oceanography. • Additional networking opportunities The 9th Future of Genomic Medicine conference will be the next iteration Educational Objectives of taking genomic knowledge to transform the daily practice of medicine. After attending this activity, participants should be able to: To do this, we have patients present their story of how genomics affected • Demonstrate the unmet needs of their medical status, and have an international faculty of experts in genomics, medicine today with respect to more targeted, individualized prevention science and medical journalism, and the life science industry provide critical and treatments. perspective. This year we will be paying particular attention to the exciting • Discuss the opportunities of the genome, proteome, metabolome area of genomic editing to treat particular diseases, cancer (a disease of the discovery to change medical practice as it exists today. genome), and the genomics of rare and unknown diseases. Furthermore, we • Assess how changes and advances in will delve into to the hot topics of the microbiome, genomic-guided drug technology are rapidly ushering in a whole array of new pathways for therapies and genomic analytics. The overarching goal of the conference is individualized medicine of the future. to spearhead efforts to use genomic knowledge to change medicine and make • Explore specific strategies in cancer, idiopathic and pharmacogenomic it far more precise and individualized. futuristic interventions. We look forward to your participation and another successful conference. Target Audience • Physicians • Human geneticists • Genomic scientists • Researchers • Health care professionals of all Eric J. Topol, MD disciplines interested in the future Course Director of medicine, especially with respect to individualized therapies Disclosures and About Scripps Disclosure About Scripps Translational Science Institute Commercial Support The Scripps Translational Science Institute (STSI) aims to replace the status-quo This course is supported, in part, by educational of one-size-fits-all-medicine with individualized health care that is based on the grants from industry. At the time of printing, a known genetic factors influencing health and disease and that takes advantage complete listing of commercial supporters was of advances in digital technology for real-time health monitoring. not available. Appropriate acknowledgement will be given to all supporters at the time of the Since its founding in 2006 by Scripps Health, STSI has been distinguished by educational activity. its leadership in translational genomics and for harnessing digital, or wireless, medical technology for health monitoring of individual patients. In addition, it is Cultural and Linguistic Competency the only member of the National Institutes of Health’s Clinical and Translational This activity is in compliance with California As- Science Award (CTSA) consortium that is not affiliated with a university. sembly Bill 1195 which requires that all CME activities comprising a patient care element in- STSI hybridizes The Scripps Research Institute (TSRI) ‘s considerable biomedical clude curriculum addressing the topic of cultur- science expertise with Scripps Health’s exceptional patient care and clinical re- al and linguistic competency. The intent of this search. As a translational bridge between TSRI and Scripps Health, STSI fosters bill is to ensure that health care professionals innovative programs and methodology, provides an optimal setting for training are able to meet the cultural and linguistic con- and education and accelerates the conduct of studies that will have the greatest cerns of a diverse patient population through potential impact on the practice of health care in the clinic and the community. effective and appropriate professional develop- ment. Cultural and linguistic competency was For more information on the Scripps Translational Science Institute, visit incorporated into the planning of this activity. www.stsiweb.org. Faculty Course Director Eric J. Topol, MD George M. Church, PhD Tuuli Lappalainen, PhD Director Professor of Genetics Assistant Professor, Department of Scripps Translational Science Institute Harvard Medical School Systems Biology at Columbia University Chief Academic Officer, Scripps Health Director of Center for Junior Investigator and Core Member Professor of Genomics Computational Genetics New York Genome Center Boston, Massachusetts New York City, New York The Scripps Research Institute La Jolla, California Mirza Cifric David H. Ledbetter, PhD, FACMG F o u n d e r a n d C h i e f E x e c u t i v e O f fi c e r Executive Vice President and Veritas Genetics Chief Scientific Officer Planning Committee Boston, Massachusetts Geisinger’s Autism & Developmental Kristian Andersen, PhD Medicine Institute (ADMI) Assistant Professor Andrew J. Conrad, PhD Lewisburg, Pennsylvania The Scripps Research Institute Chief Executive Officer Director, Infectious Disease Genomics Google Life Sciences Nick Leschly Scripps Translational Science Institute Mountain View, California Chief Executive Officer La Jolla, California Bluebird Bio Chad Cowan, PhD Cambridge, Massachusetts Laura Nicholson, MD, PhD Harvard University Department of Co-Director of Education Stem Cell and Regenerative Biology Elisa Long, PhD Scripps Translational Science Institute Massachusetts General Hospital Assistant Professor in Decisions, Associate Program Director, Medicine Cambridge, Massachusetts Operations & Technology Management Residency, Scripps Green Hospital University of California, Los Angeles Zubin Damania, MD Los Angeles, California La Jolla, California Chief Executive Officer Emily Spencer, PhD Turntable Health Elaine R. Mardis, PhD Assistant Professor Chief Rapper, ZDogg LLC Robert E. and Louise F. Dunn Scripps Translational Science Institute Las Vegas, Nevada Distinguished Professor of Medicine Co-director, McDonnell Genome Director, Clinical Genomics Program Helmy Eltoukhy, PhD La Jolla, California Institute at Washington University Chief Executive Officer St. Louis, Missouri Steven R. Steinhubl, MD Guardant Health Director of Digital Medicine Redwood City, California Jessica Richman Scripps Translational Science Institute Co-Founder Elad Gil uBiome La Jolla, California Chief Executive Officer Andrew Su, PhD Color Genomics Beth A. Shapiro, DPhil Associate Professor San Francisco, California Associate Professor Department of Ecology & The Scripps Research Institute David B. Goldstein, PhD La Jolla, California Evolutionary Biology Director University of California, Santa Cruz Ali Torkamani, PhD Institute for Genomic Medicine Santa Cruz, California Director of Genome Informatics and New York City, New York Patrick Soon-Shiong, MD Drug Discovery Robert C. Green, MD, MPH Scripps Translational Science Institute Surgeon and Medical Researcher Director University of California, Los Angeles Assistant Professor of Molecular and Genomes2People Research Program Experimental Medicine Businessman and Philanthropist Division of Genetics Los Angeles, California The Scripps Research Institute Brigham and Women’s Hospital, Broad La Jolla, California Institute and Harvard Medical School Victor E. Velculescu, MD, PhD Co-Director, Cancer Biology Nathan E. Wineinger, PhD Boston, Massachusetts Assistant Professor Professor, Oncology and Pathology Hakon Hakonarson, MD, PhD Johns Hopkins University Director of Biostatistics Director, Center for Applied Genomics Scripps Translational Science Institute Kimmel Cancer Center The Children’s Hospital of Philadelphia Baltimore, Maryland La Jolla, California University of Pennsylvania School of Medicine Ron Winslow Faculty Philadelphia, Pennsylvania Deputy Editor, Health and Science and Senior Medical and Health Care Writer Gonçalo Abecasis, PhD David Haussler, PhD Wall Street Journal Chair Department of Biostatistics Investigator School of Public Health Howard Hughes Medical Institute Anne E. Wojcicki University of Michigan Scientific Director Chief Executive Officer and Co-Founder Ann Arbor, Michigan UC Santa Cruz Genomics Institute 23andMe Santa Cruz, California Mountain View, California Atul Butte, MD, PhD Director Erika Check Hayden Institute for Computational Health Sciences Reporter, Nature University of California, San Francisco Professor Executive Director for Clinical Informatics University of California, Santa Cruz University of California Health San Francisco, California San Francisco, California Elizabeth Holmes Charles Chiu, MD, PhD Chief Executive Officer Associate Professor Theranos Laboratory Medicine and Medicine Palo Alto, California Infectious Diseases Leroy Hood, MD, PhD University of California, San Francisco President San Francisco, California Institute for Systems Biology Seattle, Washington Agenda Thursday, March 3, 2016 Afternoon