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International Collaborative Exercises (Ice)
INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE) Summary Report BIOLOGICAL SPECIMENS 2013/2 INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) INTERNATIONAL COLLABORATIVE EXERCISES (ICE) Table of contents Introduction Page 3 Comments from the International Panel of Forensic Experts Page 3 Codes and Abbreviations Page 4 Sample 1 Analysis Page 5 Identified substances Page 5 Statement of findings Page 6 Identification methods Page 10 Summary Page 12 Z-Scores Page 13 Sample 2 Analysis Page 15 Identified substances Page 15 Statement of findings Page 16 Identification methods Page 20 Summary Page 22 Z-Scores Page 23 Sample 3 Analysis Page 25 Identified substances Page 25 Statement of findings Page 27 Identification methods Page 31 Summary Page 33 Z-Scores Page 34 Sample 4 Analysis Page 36 Identified substances Page 36 Statement of findings Page 38 Identification methods Page 42 Summary Page 44 Test Samples Information Samples Comments on samples Sample 1 To prepare BS-1, urine was spiked with 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) (1590 ng base/ml), as an ethanolic solution. The spiked urine was dispensed in 50ml aliquots and lyophilised Sample 2 To prepare BS-2, urine was spiked with Gammahydroxybutyrate (GHB) (14360 ng base/ml), as an aqueous solution. The spiked urine was dispensed in 50ml aliquots and lyophilised Sample 3 To prepare BS-3, urine was spiked with Amfetamine sulphate (1570ng/ml, 1150 ng base/ml) and Metamfetamine hydrochloride (4290 ng/ml, 3450 ng base/ml) as aqueous solutions. The spiked urine was dispensed in 50ml aliquots and lyophilised Sample 4 BS-4 was a blank test sample containing no substances in the ICE menu Samples Substances Concentrations Comments on substances Sample 1 4-Bromo-2,5-dimethoxyphenethylamine (2C- 1590 ng/ml B) Sample 2 gamma-Hydroxybutyric acid (GHB) 14360 ng/ml Sample 3 Metamfetamine 3450 ng/ml Amfetamine 1150 ng/ml Sample 4 [blank sample] This report contains the data received from laboratories participating in the current exercise. -
Nové Rekreační Drogy
Neurotoxikologie nových „legálních rekreačních drog“ ze skupin empatogenů/entaktogenů a disociativ MUDr. S. Zakharov, CSc. Toxikologické informa ční st ředisko1 Klinika pracovního léka řství Nové rekrea ční drogy („Legal Highs“) - pojem • Nové syntetické psychoaktivní látky neuvedené v Jednotné Úmluv ě o omamných látkách, v zákonu č. 167/1998 Sb.; • Prodávají se legáln ě přes internet („smartshops“, „rostliny- zahrada-online“, „výzkumné chemikálie“, e-inzeráty, aj.) • „Je to jako hra na chemickou ruskou ruletu, protože nejsou údaje o toxicit ě, biometabolitech, fakrmakokinetice…“ (John W. Huffman) • „Clubbers‘ drugs“ – používají ~40% návštěvníků no čních klub ů •Účinky: stimulanty, empatogeny/entaktogeny, halucinogeny (psychedelika, delirianty, disociativa), sedativa, a kombinace… 2 Nové rekrea ční drogy • Výroba v Jihovýchodní Asii, Číně, balení a distribuce v Evropě a Spojených Státech. • Jednoduchá schémata syntézy (2-3 chemické reakce, běžné reagens (toluen, aceton...), vysoká stupe ň chemické čistoty (99%), nízké ceny; • Chemická struktura je podobná struktuře zakázaných (kontrolovaných) psychoaktivních látek; • „Výzkumné chemikálie“ seznam.cz –– 51 odkaz; google.cz – 82 700 odkaz ů; • www.bulkresearchchemicals.com; http://vip- 3 legals.com; www.buyanychem.com MDMA („Extáze“, éčko, koláč) – 3,4- MetylenDioxy-N-Metyl Amfetamin) • Syntezována v r. 1912 (A.Kollisch, Merck), rekrea ční použití od r. 1963, zákaz - 1985 (SZO, USA). • „Droga lásky“: empatogen ( R. Metzner, 1983) nebo entaktogen ( D. Nichols, 1986) - indukce pocit ů empatie, vcítění, soudružnosti, lásky, emoční blízkosti. • MDMA-asistovaná psychoterapie v léčbě posttraumatických stresových poruch (PTSD), (výzkum sponzorován MAPS USA (Multidisciplinary Association For Psychedelic Studies). • V ČR „malé množství“ – do 4 tbl. (400 mg). 4 Mechanismus účinku a toxicita MDMA • Efektivně uvol ňuje a inhibuje zpětné vychytávání SER (afinita k presynaptic- kému SERT), méně – DAT, NAT • Mírně nespecificky inhibuje MAO (A, B) • Mírný agonista 5-HT2-Re (změna percepce), DA2- Re (euforia), NA-Re (symp-mim. -
Recommended Methods for the Identification and Analysis of Synthetic Cathinones in Seized Materialsd
Recommended methods for the Identification and Analysis of Synthetic Cathinones in Seized Materials (Revised and updated) MANUAL FOR USE BY NATIONAL DRUG ANALYSIS LABORATORIES Photo credits:UNODC Photo Library; UNODC/Ioulia Kondratovitch; Alessandro Scotti. Laboratory and Scientific Section UNITED NATIONS OFFICE ON DRUGS AND CRIME Vienna Recommended Methods for the Identification and Analysis of Synthetic Cathinones in Seized Materials (Revised and updated) MANUAL FOR USE BY NATIONAL DRUG ANALYSIS LABORATORIES UNITED NATIONS Vienna, 2020 Note Operating and experimental conditions are reproduced from the original reference materials, including unpublished methods, validated and used in selected national laboratories as per the list of references. A number of alternative conditions and substitution of named commercial products may provide comparable results in many cases. However, any modification has to be validated before it is integrated into laboratory routines. ST/NAR/49/REV.1 Original language: English © United Nations, March 2020. All rights reserved, worldwide. The designations employed and the presentation of material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations concerning the legal status of any country, territory, city or area, or of its authorities, or concerning the delimitation of its frontiers or boundaries. Mention of names of firms and commercial products does not imply the endorse- ment of the United Nations. This publication has not been formally edited. Publishing production: English, Publishing and Library Section, United Nations Office at Vienna. Acknowledgements The Laboratory and Scientific Section of the UNODC (LSS, headed by Dr. Justice Tettey) wishes to express its appreciation and thanks to Dr. -
Mephedrone Is a Class B Drug, Which Means Self-Referral Form and It Is Illegal to Possess, Sell Or Give Away
THE LAW CONTACT INFORMATION Novel Psychoacve Substances (NPS) are If you would like support controlled substances under the Misuse of around your substance HMP BRISTOL Drugs Act (1971). use, please complete a Substance Misuse Team Mephedrone is a Class B drug, which means self-referral form and it is illegal to possess, sell or give away. return to Health Care. Possession can result in prosecuon and up PALS to a five year prison sentence or an unlimited fine. To make a comment, raise a concern Mephedrone or make a complaint, please contact the Trust’s Paent Advice and Liaison Supplying someone else, even your friends, Service (PALS). can result in a prison sentence of up to 14 Know the effects years or an unlimited fine. Tel: 01249 468261 Freephone: 0800 073 1778 Email: [email protected] Being convicted of a drug‐related offence could have a serious impact on your future. This could affect the types of jobs you apply for and stop you from entering certain OTHER FORMATS OR countries. LANGUAGES If you need this informaon in other formats (such as large print, Braille) or in another language, please call PALS Lead: Chris Eade Leaflet code: 326 Approval date: Aug 2014 Review due: Aug 2017 WHAT IS MEPHEDRONE EFFECTS THE RISKS Mephedrone is also known as The effects of mephedrone can vary and All drugs pose a risk of dependency and meow meow, meph, m‐cat and miaow can affect people differently. It is never can cause short and long‐term damage certain what effect it will have on the user. -
Quantification of Drugs of Abuse in Municipal Wastewater Via SPE and Direct Injection Liquid Chromatography Mass Spectrometry
Anal Bioanal Chem (2010) 398:2701–2712 DOI 10.1007/s00216-010-4191-9 ORIGINAL PAPER Quantification of drugs of abuse in municipal wastewater via SPE and direct injection liquid chromatography mass spectrometry Kevin J. Bisceglia & A. Lynn Roberts & Michele M. Schantz & Katrice A. Lippa Received: 2 June 2010 /Revised: 30 August 2010 /Accepted: 2 September 2010 /Published online: 24 September 2010 # US Government 2010 Abstract We present an isotopic-dilution direct injection 50 ng/L. We also present a modified version of this method reversed-phase liquid chromatography–tandem mass spec- that incorporates solid-phase extraction to further enhance trometry method for the simultaneous determination of 23 sensitivity. The method includes a confirmatory LC separa- drugs of abuse, drug metabolites, and human-use markers in tion (selected by evaluating 13 unique chromatographic municipal wastewater. The method places particular emphasis phases) that has been evaluated using National Institute of on cocaine; it includes 11 of its metabolites to facilitate Standards and Technology Standard Reference Material 1511 assessment of routes of administration and to enhance the Multi-Drugs of Abuse in Freeze-Dried Urine. Seven analytes accuracy of estimates of cocaine consumption. Four opioids (ecgonine methyl ester, ecgonine ethyl ester, anhydroecgo- (6-acetylmorphine, morphine, hydrocodone, and oxycodone) nine methyl ester, m-hydroxybenzoylecgonine, p-hydroxy- are also included, along with five phenylamine drugs benzoyl-ecgonine, ecgonine, and anhydroecgonine) were (amphetamine, methamphetamine, 3,4-methylenedioxy- detected for the first time in a wastewater sample. methamphetamine, methylbenzodioxolyl-butanamine, and 3,4-methylenedioxy-N-ethylamphetamine) and two human- Keywords Wastewater . Illicit drugs . Urinary metabolites . use markers (cotinine and creatinine). -
(12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 De Juan Et Al
US 200601 10428A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 de Juan et al. (43) Pub. Date: May 25, 2006 (54) METHODS AND DEVICES FOR THE Publication Classification TREATMENT OF OCULAR CONDITIONS (51) Int. Cl. (76) Inventors: Eugene de Juan, LaCanada, CA (US); A6F 2/00 (2006.01) Signe E. Varner, Los Angeles, CA (52) U.S. Cl. .............................................................. 424/427 (US); Laurie R. Lawin, New Brighton, MN (US) (57) ABSTRACT Correspondence Address: Featured is a method for instilling one or more bioactive SCOTT PRIBNOW agents into ocular tissue within an eye of a patient for the Kagan Binder, PLLC treatment of an ocular condition, the method comprising Suite 200 concurrently using at least two of the following bioactive 221 Main Street North agent delivery methods (A)-(C): Stillwater, MN 55082 (US) (A) implanting a Sustained release delivery device com (21) Appl. No.: 11/175,850 prising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more (22) Filed: Jul. 5, 2005 bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more Related U.S. Application Data bioactive agents Subretinally; and (60) Provisional application No. 60/585,236, filed on Jul. (C) instilling (e.g., injecting or delivering by ocular ion 2, 2004. Provisional application No. 60/669,701, filed tophoresis) one or more bioactive agents into the Vit on Apr. 8, 2005. reous humor of the eye. Patent Application Publication May 25, 2006 Sheet 1 of 22 US 2006/0110428A1 R 2 2 C.6 Fig. -
2015-02 Toxicology Rapid Testing Panel
SOUTH CAROLINA LAW ENFORCEMENT DIVISION NIKKI R. HALEY MARK A. KEEL Governor Chief FORENSIC SERVICES LABORATORY CUSTOMER NOTICE 2015-02 REGARDING TOXICOLOGY RAPID TESTING PANEL August 12, 2015 This notice is to inform the Coroners of South Carolina of a new testing panel available through the SLED Toxicology Department. On Monday, August 17th, the Toxicology Department will begin offering both a Rapid Testing Panel in addition to the already available Expanded Testing Panel. This Rapid Testing Panel is to be utilized in cases where the Expanded Testing Panel is not warranted, specifically where a cause of death has already been established. The Rapid Testing Panel will consist of volatiles analysis, to include, ethanol, acetone, isopropanol and methanol, drug screens, and drug confirmation/quantitation of positive screens. The cases assigned to the Rapid Testing Panel will have an expedited turnaround time. Targeted turn around times will be two weeks for negative cases and six weeks or less for positive cases. While every effort will be made to adhere to these time frames, additional time may be required on occasion due to the nature of postmortem samples. Submitters will be notified if there is a problem with a particular sample. Please see attachment regarding specifically which substances are covered by the Rapid Testing Panel and the Expanded Testing Panel. As always, a detailed case history and list of drugs suspected is appreciated. Rapid Panel and Expanded Panel will be choices available in iLAB. Please contact Lt. Dustin Smith (803-896-7385) with additional questions. ALI-359-T An Accredited Law Enforcement Agency P.O. -
3,4-Methylenedioxymethcathinone (Methylone) [“Bath Salt,” Bk-MDMA, MDMC, MDMCAT, “Explosion,” “Ease,” “Molly”] December 2019
Drug Enforcement Administration Diversion Control Division Drug & Chemical Evaluation Section 3,4-Methylenedioxymethcathinone (Methylone) [“Bath salt,” bk-MDMA, MDMC, MDMCAT, “Explosion,” “Ease,” “Molly”] December 2019 Introduction: discriminate DOM from saline. 3,4-Methylenedioxymethcathinone (methylone) is a Because of the structural and pharmacological similarities designer drug of the phenethylamine class. Methylone is a between methylone and MDMA, the psychoactive effects, adverse synthetic cathinone with substantial chemical, structural, and health risks, and signs of intoxication resulting from methylone pharmacological similarities to 3,4-methylenedioxymeth- abuse are likely to be similar to those of MDMA. Several chat amphetamine (MDMA, ecstasy). Animal studies indicate that rooms discussed pleasant and positive effects of methylone when methylone has MDMA-like and (+)-amphetamine-like used for recreational purpose. behavioral effects. When combined with mephedrone, a controlled schedule I substance, the combination is called User Population: “bubbles.” Other names are given in the above title. Methylone, like other synthetic cathinones, is a recreational drug that emerged on the United States’ illicit drug market in 2009. It is perceived as being a ‘legal’ alternative to drugs of Licit Uses: Methylone is not approved for medical use in the United abuse like MDMA, methamphetamine, and cocaine. Evidence States. indicates that youths and young adults are the primary users of synthetic cathinone substances which include methylone. However, older adults also have been identified as users of these Chemistry: substances. O H O N CH3 Illicit Distribution: CH O 3 Law enforcement has encountered methylone in the United States as well as in several countries including the Netherlands, Methylone United Kingdom, Japan, and Sweden. -
(19) United States (12) Patent Application Publication (10) Pub
US 20130289061A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2013/0289061 A1 Bhide et al. (43) Pub. Date: Oct. 31, 2013 (54) METHODS AND COMPOSITIONS TO Publication Classi?cation PREVENT ADDICTION (51) Int. Cl. (71) Applicant: The General Hospital Corporation, A61K 31/485 (2006-01) Boston’ MA (Us) A61K 31/4458 (2006.01) (52) U.S. Cl. (72) Inventors: Pradeep G. Bhide; Peabody, MA (US); CPC """"" " A61K31/485 (201301); ‘4161223011? Jmm‘“ Zhu’ Ansm’ MA. (Us); USPC ......... .. 514/282; 514/317; 514/654; 514/618; Thomas J. Spencer; Carhsle; MA (US); 514/279 Joseph Biederman; Brookline; MA (Us) (57) ABSTRACT Disclosed herein is a method of reducing or preventing the development of aversion to a CNS stimulant in a subject (21) App1_ NO_; 13/924,815 comprising; administering a therapeutic amount of the neu rological stimulant and administering an antagonist of the kappa opioid receptor; to thereby reduce or prevent the devel - . opment of aversion to the CNS stimulant in the subject. Also (22) Flled' Jun‘ 24’ 2013 disclosed is a method of reducing or preventing the develop ment of addiction to a CNS stimulant in a subj ect; comprising; _ _ administering the CNS stimulant and administering a mu Related U‘s‘ Apphcatlon Data opioid receptor antagonist to thereby reduce or prevent the (63) Continuation of application NO 13/389,959, ?led on development of addiction to the CNS stimulant in the subject. Apt 27’ 2012’ ?led as application NO_ PCT/US2010/ Also disclosed are pharmaceutical compositions comprising 045486 on Aug' 13 2010' a central nervous system stimulant and an opioid receptor ’ antagonist. -
4-Methylethcathinone (4-MEC)
4‐Methylethcathinone (4‐MEC) Critical Review Report Agenda item 4.15 (R/S)‐ 2‐(Ethylamino)‐1‐(4‐methylphenyl) propan‐1‐one (4‐methyl‐N‐ethylcathinone, 4‐MEC) Expert Committee on Drug Dependence Thirty‐sixth Meeting Geneva, 16‐20 June 2014 36th ECDD (2014) Agenda item 4.15 4‐Methylethcathinone (4‐MEC) Page 2 of 20 36th ECDD (2014) Agenda item 4.15 4‐Methylethcathinone (4‐MEC) Acknowledgements This report has been drafted under the responsibility of the WHO Secretariat, Essential Medicines and Health Products, Policy Access and Rational Use Unit. The WHO Secretariat would like to thank the following people for their contribution in producing this critical review report: Dr Simon Brandt, United Kingdom (literature review and drafting), Dr Caroline Bodenschatz, Switzerland (editing) and Mr David Beran, Switzerland (questionnaire report drafting). Page 3 of 20 36th ECDD (2014) Agenda item 4.15 4‐Methylethcathinone (4‐MEC) Page 4 of 20 36th ECDD (2014) Agenda item 4.15 4‐Methylethcathinone (4‐MEC) Contents Summary.................................................................................................................................................................... 7 1. Substance identification ............................................................................................................................... 8 A. International Nonproprietary Name (INN) ......................................................................................... 8 B. Chemical Abstract Service (CAS) Registry Number .......................................................................... -
WHO Expert Committee on Drug Dependence Thirty-Eighth Report
WHO Expert Committee on Drug Dependence Thirty-eighth report This report contains the views of an international group of experts, and does not necessarily represent the decisions or the stated policy of the World Health Organization iii Contents WHO Expert Committee on Drug Dependence vi Abbreviations ix Introduction 1 1. Briefings from International Organizations on their work on the public health element of the world drug problem 4 1.1 Update from the International Narcotics Control Board 4 1.2 Update from the United Nations Office on Drugs and Crime 5 1.3 Update from the Department of Essential Medicines and Health Products, WHO 7 1.4 Update from the Department of Mental Health and Substance Abuse, WHO 9 1.5 Update from the Department of HIV/AIDS, WHO 9 2. Principles for prioritizing and assessing substances as part of ECDD work 11 3. Update from the 1st Informal Working Group of the ECDD 12 4. Follow-up on recommendations made by the ECDD at its thirty-seventh meeting 13 5. Critical review of psychoactive substances 14 5.1 U- 47700 15 5.2 Butyrfentanyl (Butyrylfentanyl) 17 5.3 4-Methylethcathinone (4-MEC) 18 5.4 3-Methylmethcathinone (3-methyl-N-methylcathinone; 3-MMC) 21 iv 5.5 Ethylone (3,4-metheylenedioxy-N-ethylcathinone; bk-MDEA; MEDEC) 23 5.6 Pentedrone (α-Methylaminovalerophenone) 24 5.7 Ethylphenidate (EPH) 26 5.8 Methiopropamine (MPA) 28 5.9 MDMB-CHMICA 30 5.10 5F-APINACA (5F-AKB-48) 32 5.11 JWH-073 34 5.12 XLR-11 36 6. Updates 37 6.1 Cannabis and cannabis resin 37 7. -
Structure-Cytotoxicity Relationship Profile of 13 Synthetic Cathinones In
Neurotoxicology 75 (2019) 158–173 Contents lists available at ScienceDirect Neurotoxicology journal homepage: www.elsevier.com/locate/neuro Structure-cytotoxicity relationship profile of 13 synthetic cathinones in differentiated human SH-SY5Y neuronal cells T ⁎ Jorge Soaresa, , Vera Marisa Costaa, Helena Gasparb,c, Susana Santosd,e, Maria de Lourdes Bastosa, ⁎ Félix Carvalhoa, João Paulo Capelaa,f, a UCIBIO, REQUIMTE (Rede de Química e Tecnologia), Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Portugal b BioISI – Instituto de Biossistemas e Ciências Integrativas, Faculdade de Ciências, Universidade de Lisboa, Portugal c MARE - Centro de Ciências do Mar e do Ambiente, Escola Superior de Turismo e Tecnologia do Mar, Instituto Politécnico de Leiria, Portugal d Centro de Química e Bioquímica (CQB), Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Portugal e Centro de Química Estrutural, Faculdade de Ciências, Universidade de Lisboa, Portugal f FP-ENAS (Unidade de Investigação UFP em Energia, Ambiente e Saúde), CEBIMED (Centro de Estudos em Biomedicina), Faculdade de Ciências da Saúde, Universidade Fernando Pessoa, Portugal ARTICLE INFO ABSTRACT Keywords: Synthetic cathinones also known as β-keto amphetamines are a new group of recreational designer drugs. We Synthetic cathinones aimed to evaluate the cytotoxic potential of thirteen cathinones lacking the methylenedioxy ring and establish a Classical amphetamines putative structure-toxicity profile using differentiated SH-SY5Y cells, as well as to compare their toxicity to that Cytotoxicity of amphetamine (AMPH) and methamphetamine (METH). Cytotoxicity assays [mitochondrial 3-(4,5-dimethyl-2- SH-SY5Y cells thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) reduction and lysosomal neutral red (NR) uptake] per- Structure-toxicity relationship formed after a 24-h or a 48-h exposure revealed for all tested drugs a concentration-dependent toxicity.