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Journal of Cystic Fibrosis 19 S1 Contents Cystic Fibrosis Research Topics Featured at the CFTR processing, trafficking and interactions 16th ECFS Basic Science Conference, Dubrovnik, M.D. Amaral, D.M. Hutt, V. Tomati, H.M. Botelho, Croatia, 27-30 March, 2019 N. Pedemonte (Portugal, USA, Italy) S33 Guest Editors: Cliff Taggart, Isabelle Callebaut, Alternative chloride transport pathways as Carlos Farinha and Martin Mense pharmacological targets for the treatment of cystic Journal of Cystic Fibrosis Journal of Cystic Fibrosis Journal of Exploring the basic mechanisms in Cystic Fibrosis: fibrosis Promoting data presentation and discussion at the R. Quesada, R. Dutzler (Spain, Switzerland) S37 16th ECFS Basic Science Conference Regeneration of airway epithelial cells to study rare cell I. Callebaut, M. Mense, C.M. Farinha states in cystic fibrosis (France, USA, Portugal) S1 P. Barbry, A. Cavard, M. Chanson, A.B. Jaffe, L.W. Plasschaert (France, Switzerland, USA) S42 Cystic Fibrosis The genetics and genomics of cystic fibrosis N. Sharma, G.R. Cutting (USA) S5 Interplay between host-microbe and microbe-microbe Genetic variation in CFTR and modifier loci may interactions in cystic fibrosis The Official Journal of the European Cystic Fibrosis Society modulate cystic fibrosis disease severity C.R. Armbruster, T. Coenye, L. Touqui, A. Paranjapye, M. Ruffin, A. Harris, J.M. Bomberger (USA, Belgium, France) S47 H. Corvol (USA, France) S10 New approaches to genetic therapies for cystic fibrosis The influence of CFTR complex alleles on precision A. Christopher Boyd, S. Guo, L. Huang, therapy of cystic fibrosis B. Kerem, Y.S. Oren, A.J. Walker, B. Chevalier, A. Hinzpeter (France) S15 S.L. Hart (UK, USA, Israel) S54 CFTR: New insights into structure and function and Intestinal organoids for Cystic Fibrosis research implications for modulation by small molecules E. de Poel, J.W. Lefferts, J.M. Beekman B. Kleizen, J.F. Hunt, I. Callebaut, T.-C. Hwang, (the Netherlands) S60 I. Sermet-Gaudelus, S. Hafkemeyer, D.N. Sheppard (the Netherlands, USA, France, Germany, UK) S19 Research ECFS Cystic Fibrosis Towards next generation therapies for cystic fibrosis: Folding, function and pharmacology of CFTR S.J. Bose, G. Krainer, D.R.S. Ng, M. Schenkel, H. Shishido, J.S. Yoon, P.M. Haggie, M. Schlierf, D.N. Sheppard, W.R. Skach (UK, Germany, USA) S25 Pages S1–S186 Supplement: Cystic Fibrosis Research Topics Featured at the Volume 19 Suppl. 12 Pages S1 Abstracts of the 16th43rd EuropeanECFS Basic CysticScience Fibrosis Conference, Conference Dubrovnik, – 2020 MarchJune 2020 2020 – S64 Croatia, 27-30 March, 2019 ISSN 1569-1993 Guest Editors: Cliff Taggart, Isabelle Callebaut, ELSEVIER Carlos Farinha and Martin Mense Publication of this Abstract Book was supported by the European Cystic ELSEVIER Publication of this Supplement is supported by The European Cystic Fibrosis 4.290 SocietyFibrosis (ECFS)Society www.ECFS.eu Editorial Board Editor-in-Chief: Scott Bell, Adult Cystic Fibrosis Centre, The Prince Charles Hospital, Queensland, Australia Deputy Editors: Carlo Castellani, IRCCS Istituto Giannina Gaslini, Cystic Fibrosis Centre, Genoa, Italy Patrick Flume, Medical University of South Carolina, Charleston, South Carolina, USA Founding Editor: Harry Heijerman, Dept. of Pulmonology, Haga Teaching Hospital, The Hague, The Netherlands Editorial Board: Scott Blackman, USA Geraint Rogers, Australia Pierre-Régis Burgel, France Steven Rowe, USA Neelkamal Chaudhary, USA Laura Sherrard, UK Aleksander Edelman, France Anne Stephenson, Canada Pascale Fanen, France Cliff Taggart, UK Niels Høiby, Denmark Daan Touw, The Netherlands Paul McCray, USA Michael Tunney, N. Ireland Marianne Muhlebach, USA Donald Van Devanter, USA Gerald Pier, USA Michael Wilschanski, Israel Felix Ratjen, Canada Jeffrey Wine, USA Kristin A. Riekert, USA Susannah King, Australia Statistical Advisers: Christine Etherington, United Kingdom Christoph Meisner, Germany Editor In Chief, Cystic Fibrosis Research News: Harry Heijerman, Dept. of Pulmonology, Haga Teaching Hospital, The Hague, The Netherlands Amsterdam — Boston — London — New York — Oxford — Paris — Philadelphia — San Diego — St. Louis — Tokyo Volume 19, Supplement 12 (2020) Cystic Fibrosis Research TopicsAbstracts Featured of the at the 16th ECFS Basic Science Conference,43rd European Dubrovnik, Cystic Fibrosis Croatia, Conference 27-30xx–xx March,June – 2020 2020 2019 Guest Editors: Cliff Taggart, Isabelle Callebaut, Carlos Farinha, and Martin Mense Publication of this Supplement is supported by The European Cystic Fibrosis Society (ECFS) Publication of this Abstract Book was supported by the European Cystic Fibrosis Society. The Official Journal of the European Cystic Fibrosis Society Derivative Works Users may reproduce tables of contents or prepare lists of articles Description including abstracts for internal circulation within their institutions or The Journal of Cystic Fibrosis is the official journal of the European companies. Other than for articles published under the CC BY license, Cystic Fibrosis Society. The journal is devoted to promoting the research permission of the publisher is required for resale or distribution outside and treatment of cystic fibrosis. To this end the journal publishes original the subscribing institution or company. scientific articles, editorials, case reports, short communications and other For any subscribed articles or articles published under a CC BY-NC-ND information relevant to cystic fibrosis. The journal also publishes news and license, permission of the publisher is required for all other derivative articles concerning the activities and policies of the ECFS as well as those of works, including compilations and translations. other societies related to the ECFS. Storage or Usage Audience Except as outlined above or as set out in the relevant user license, no Pediatricians, pulmonologists, gastroenterologists, internists, microbiologists, part of this publication may be reproduced, stored in a retrieval system pharmacologists, immunologists, psychologists, basic scientists, or transmitted in any form or by any means, electronic, mechanical, physiotherapists, dieticians and nurses dealing with the investigation photocopying, recording or otherwise, without prior written permission and treatment of cystic fibrosis. of the publisher. Publication Information: Permissions Journal of Cystic Fibrosis (ISSN 1569-1993). 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