Drug-Target Pairs: R3 1

Drug-target pairs: R3 1

2865 Target 2718 DB00446 2873 Target 3810 DB01235 2881 Target 1885 DB01076

CPT STRVL Chlorampheni COMT HUMAN Levodopa CODA1 HUMAN Atorvastatin col..

Approved Approved Approved Chloramphenicol Catechol O- Collagen alpha- 3-O phospho- methyltransferase 1(XIII) chain transferase

2866 Target 2170 DB01076 2874 Target 3810 DB00323 2882 Target 1629 DB00570

RHOA HUMAN Atorvastatin COMT HUMAN Tolcapone JUN HUMAN Vinblastine

Approved Approved Approved Transforming pro- Catechol O- Transcription fac- tein RhoA precur- methyltransferase tor AP-1 sor

2867 Target 4101 DB00188 2875 Target 3810 DB00494 2883 Target 1629 DB01029

PSB1 HUMAN Bortezomib COMT HUMAN Entacapone JUN HUMAN Irbesartan

Approved Approved Approved Proteasome Catechol O- Transcription fac- subunit beta type methyltransferase tor AP-1 1

2868 Target 4103 DB00188 2876 Target 2650 DB03336 2884 Target 1291 DB01200

PSB2 HUMAN Bortezomib COMT RAT BIA CREB1 HUMAN Bromocriptin e..

Approved Approved Proteasome Catechol O- cAMP response subunit beta type methyltransferase element-binding 2 protein

2869 Target 4102 DB00188 2877 Target 1374 DB01136 2885 Target 1291 DB01183

PSB5 HUMAN Bortezomib ANFB HUMAN Carvedilol CREB1 HUMAN Naloxone

Approved Approved Approved Proteasome Natriuretic cAMP response subunit beta type peptides B pre- element-binding 5 cursor [Contains: protein Gamma-brain natriuretic peptide; Brain natriuretic peptide 32 2870 Target 5751 DB04732 2878 Target 4790 DB00512 2886 Target 1262 DB00836

O33244 MYCTU N-(4-MORPHOL P96558 AMYOR Vancomycin COLI HUMAN Loperamide INE)CA..

Approved Approved Proteasome Glycosyltransferase Corticotropin- GtfA lipotropin precursor

2871 Target 2553 DB03314 2879 Target 1123 DB01411 2887 Target 1262 DB01548

GSTM1 RAT Fluorotrypto ECP HUMAN Pranlukast COLI HUMAN Diprenorphin phane.. e..

Approved Glutathione Eosinophil Corticotropin- S-transferase Mu cationic protein lipotropin 1 precursor precursor

2872 Target 652 DB01058 2880 Target 512 DB00615 2888 Target 1262 DB01497

GST26 SCHJA Praziquantel RPOA ECOLI Rifabutin COLI HUMAN Etorphine

Approved Approved Glutathione DNA-directed Corticotropin- S-transferase 26 RNA polymerase lipotropin kDa alpha chain precursor Drug-target pairs: R3 2

2889 Target 1262 DB01565 2897 Target 1716 DB01565 2905 Target 1284 DB00163

COLI HUMAN Dihydromorph TRI13 HUMAN Dihydromorph PXR HUMAN Vitamin E ine.. ine..

Approved Corticotropin- Tripartite motif- Orphan nuclear lipotropin containing protein receptor PXR precursor 13

2890 Target 3955 DB03496 2898 Target 1716 DB01497 2906 Target 1284 DB01045

CDK6 HUMAN Flavopiridol TRI13 HUMAN Etorphine PXR HUMAN Rifampin

Approved Cell division pro- Tripartite motif- Orphan nuclear tein kinase 6 containing protein receptor PXR 13

2891 Target 3959 DB03496 2899 Target 1716 DB01548 2907 Target 3936 DB00675

CDK4 HUMAN Flavopiridol TRI13 HUMAN Diprenorphin TYPH HUMAN Tamoxifen e..

Approved Cell division pro- Tripartite motif- Thymidine tein kinase 4 containing protein phosphorylase 13

2892 Target 3482 DB03496 2900 Target 1226 DB01466 2908 Target 736 DB01207

CDK7 HUMAN Flavopiridol MBD2 HUMAN Ethylmorphin O14987 HUMAN Ridogrel e..

Approved Cell division pro- Methyl-CpG- Thromboxane A2 tein kinase 7 binding domain synthase protein 2

2893 Target 1771 DB03496 2901 Target 5251 DB04463 2909 Target 736 DB03052

CDC2 HUMAN Flavopiridol CBR1 HUMAN 3-(4-Amino-1 O14987 HUMAN Dazoxiben -Tert-..

Cell division con- Carbonyl reduc- Thromboxane A2 trol protein 2 ho- tase [NADPH] synthase molog 1

2894 Target 1058 DB03496 2902 Target 3952 DB00773 2910 Target 3448 DB03052

CDK5 HUMAN Flavopiridol MP2K7 HUMAN Etoposide THAS HUMAN Dazoxiben

Approved Cell division pro- Dual specificity Thromboxane-A tein kinase 5 mitogen-activated synthase protein kinase kinase 7

2895 Target 1982 DB01548 2903 Target 1284 DB00783 2911 Target 838 DB00688

PDYN HUMAN Diprenorphin PXR HUMAN Estradiol IMDH1 HUMAN Mycophenolat e.. e mofe..

Approved Approved Beta- Orphan nuclear Inosine-5’- neoendorphin- receptor PXR monophosphate dynorphin dehydrogenase 1 precursor

2896 Target 5730 DB04653 2904 Target 1284 DB00977 2912 Target 838 DB01024

CAN1 HUMAN CBZ-LEU-LEU- PXR HUMAN Ethinyl Estr IMDH1 HUMAN Mycophenolic TYR-CH.. adiol.. acid..

Approved Approved Calpain-1 Orphan nuclear Inosine-5’- catalytic subunit receptor PXR monophosphate dehydrogenase 1 Drug-target pairs: R3 3

2913 Target 2354 DB01024 2921 Target 80 DB01076 2929 Target 750 DB00343

IMDH2 CRIGR Mycophenolic PPARA HUMAN Atorvastatin CCG1 HUMAN Diltiazem acid..

Approved Approved Approved Inosine-5’- Peroxisome Voltage- monophosphate proliferator- dependent dehydrogenase 2 activated receptor calcium channel alpha gamma-1 subunit

2914 Target 796 DB01024 2922 Target 822 DB02712 2930 Target 750 DB00661

IMDH2 HUMAN Mycophenolic ALDR HUMAN Sorbinil CCG1 HUMAN Verapamil acid..

Approved Approved Inosine-5’- Aldose reductase Voltage- monophosphate dependent dehydrogenase 2 calcium channel gamma-1 subunit

2915 Target 796 DB00688 2923 Target 822 DB00605 2931 Target 3876 DB00190

IMDH2 HUMAN Mycophenolat ALDR HUMAN Sulindac DDC HUMAN Carbidopa e mofe..

Approved Approved Approved Inosine-5’- Aldose reductase Aromatic-L- monophosphate amino-acid dehydrogenase 2 decarboxylase

2916 Target 2316 DB01024 2924 Target 750 DB00381 2932 Target 3876 DB00150

IMDH TRIFO Mycophenolic CCG1 HUMAN Amlodipine DDC HUMAN L-Tryptophan acid..

Approved Approved Approved Inosine-5’- Voltage- Aromatic-L- monophosphate dependent amino-acid dehydrogenase calcium channel decarboxylase gamma-1 subunit

2917 Target 1867 DB00759 2925 Target 750 DB00528 2933 Target 1654 DB01017

PRIO HUMAN Tetracycline CCG1 HUMAN Lercanidipin IL1B HUMAN Minocycline e..

Approved Approved Approved Major prion pro- Voltage- Interleukin-1 beta tein precursor dependent precursor calcium channel gamma-1 subunit

2918 Target 80 DB01241 2926 Target 750 DB01054 2934 Target 1654 DB01366

PPARA HUMAN Gemfibrozil CCG1 HUMAN Nitrendipine IL1B HUMAN Procaterol

Approved Approved Approved Peroxisome Voltage- Interleukin-1 beta proliferator- dependent precursor activated receptor calcium channel alpha gamma-1 subunit

2919 Target 80 DB01039 2927 Target 750 DB00393 2935 Target 2706 DB00693

PPARA HUMAN Fenofibrate CCG1 HUMAN Nimodipine KV2A7 MOUSE Fluorescein

Approved Approved Approved Peroxisome Voltage- Ig kappa chain V- proliferator- dependent II region 26-10 activated receptor calcium channel alpha gamma-1 subunit

2920 Target 80 DB01393 2928 Target 750 DB00308 2936 Target 787 DB00498

PPARA HUMAN Bezafibrate CCG1 HUMAN Ibutilide VKOR1 HUMAN Phenindione

Approved Approved Approved Peroxisome Voltage- Vitamin K epox- proliferator- dependent ide reductase com- activated receptor calcium channel plex subunit 1 alpha gamma-1 subunit Drug-target pairs: R3 4

2937 Target 787 DB00170 2945 Target 2267 DB04790 2953 Target 2417 DB00446

VKOR1 HUMAN Menadione TRY1 BOVIN 2,5-bis-o-(3 CAT4 PSEAE Chlorampheni -[amin.. col..

Approved Approved Vitamin K epox- Cationic trypsin Chloramphenicol ide reductase com- precursor acetyltransferase plex subunit 1

2938 Target 787 DB00266 2946 Target 2267 DB04791 2954 Target 5765 DB04782

VKOR1 HUMAN Dicumarol TRY1 BOVIN 2-O-(4’-AMID Q7AUG5 RHISH (S)-4-Nitros INOPHE.. tyrene..

Approved Vitamin K epox- Cationic trypsin 2,3-dichloro- ide reductase com- precursor 1-propanol plex subunit 1 dehalogenase

2939 Target 787 DB00682 2947 Target 2267 DB04792 2955 Target 5683 DB04777

VKOR1 HUMAN Warfarin TRY1 BOVIN 2,5-O,O-BIS- Q93D82 9RHIZ (R)-4-Nitros (4’,4’.. tyrene..

Approved Vitamin K epox- Cationic trypsin Halohydrin ide reductase com- precursor dehalogenase plex subunit 1

2940 Target 787 DB00946 2948 Target 2261 DB01650 2956 Target 5749 DB04723

VKOR1 HUMAN Phenprocoumo FRA1 VIBFI trans-2-hydr CBPB1 PIG 2-(3-GUANIDI n.. oxycin.. NOPHEN..

Approved Vitamin K epox- Major NAD(P)H- Carboxypeptidase ide reductase com- flavin oxidoreduc- B plex subunit 1 tase

2941 Target 787 DB01418 2949 Target 2261 DB03410 2957 Target 506 DB00348

VKOR1 HUMAN Acenocoumaro FRA1 VIBFI 4-hydroxycou HPPD HUMAN Nitisinone l.. marin..

Approved Approved Vitamin K epox- Major NAD(P)H- 4- ide reductase com- flavin oxidoreduc- hydroxyphenylpyruvate plex subunit 1 tase dioxygenase

2942 Target 562 DB00374 2950 Target 5741 DB04685 2958 Target 2834 DB04737

CCL23 HUMAN Treprostinil Q8II92 PLAF7 1-((2S,5S)-4 HNL HEVBR (S)-HYDROXY( -FLUOR.. PHENYL..

Approved Small inducible Deoxyuridine (S)-acetone- cytokine A23 5’-triphosphate cyanohydrin precursor nucleotidohydro- lyase lase, putative

2943 Target 2265 DB01662 2951 Target 269 DB00648 2959 Target 4071 DB00162

CTRA BOVIN Trans-O-Hydr ADX HUMAN Mitotane DHRS3 HUMAN Vitamin A oxy-Al..

Approved Approved Chymotrypsinogen Adrenodoxin, Short-chain A mitochondrial dehydroge- precursor nase/reductase 3

2944 Target 2267 DB04793 2952 Target 243 DB00170 2960 Target 4077 DB00163

TRY1 BOVIN 2-O-(3’-AMID NQO2 HUMAN Menadione PP2AB HUMAN Vitamin E INOPHE..

Approved Approved Cationic trypsin Ribosyldihydronicotinamide Serine/threonine- precursor dehydrogenase protein phos- [quinone] phatase 2A catalytic subunit beta isoform Drug-target pairs: R3 5

2961 Target 4078 DB00163 2969 Target 88 DB00210 2977 Target 459 DB00459

PP2AA HUMAN Vitamin E RXRB HUMAN Adapalene RXRA HUMAN Acitretin

Approved Approved Approved Serine/threonine- Retinoic acid re- Retinoic acid re- protein phos- ceptor RXR-beta ceptor RXR-alpha phatase 2A catalytic subunit alpha isoform

2962 Target 86 DB00163 2970 Target 88 DB00459 2978 Target 459 DB00523

S14L4 HUMAN Vitamin E RXRB HUMAN Acitretin RXRA HUMAN Alitretinoin

Approved Approved Approved SEC14-like Retinoic acid re- Retinoic acid re- protein 4 ceptor RXR-beta ceptor RXR-alpha

2963 Target 375 DB00163 2971 Target 88 DB00926 2979 Target 780 DB00755

S14L3 HUMAN Vitamin E RXRB HUMAN Etretinate RXRG HUMAN Tretinoin

Approved Approved SEC14-like Retinoic acid re- Retinoic acid protein 3 ceptor RXR-beta receptor RXR- gamma

2964 Target 283 DB00163 2972 Target 780 DB00459 2980 Target 780 DB00523

S14L2 HUMAN Vitamin E RXRG HUMAN Acitretin RXRG HUMAN Alitretinoin

Approved Approved Approved SEC14-like Retinoic acid Retinoic acid protein 2 receptor RXR- receptor RXR- gamma gamma

2965 Target 88 DB00523 2973 Target 780 DB00926 2981 Target 229 DB00799

RXRB HUMAN Alitretinoin RXRG HUMAN Etretinate RARB HUMAN Tazarotene

Approved Approved Retinoic acid re- Retinoic acid Retinoic acid receptor RXR-beta receptor RXR- ceptor beta gamma

2966 Target 88 DB00755 2974 Target 780 DB00210 2982 Target 229 DB00210

RXRB HUMAN Tretinoin RXRG HUMAN Adapalene RARB HUMAN Adapalene

Approved Approved Approved Retinoic acid re- Retinoic acid Retinoic acid receptor RXR-beta receptor RXR- ceptor beta gamma

2967 Target 88 DB00799 2975 Target 459 DB00210 2983 Target 730 DB00210

RXRB HUMAN Tazarotene RXRA HUMAN Adapalene RARA HUMAN Adapalene

Approved Approved Approved Retinoic acid re- Retinoic acid re- Retinoic acid receptor RXR-beta ceptor RXR-alpha ceptor alpha

2968 Target 88 DB00307 2976 Target 459 DB00926 2984 Target 730 DB00799

RXRB HUMAN Bexarotene RXRA HUMAN Etretinate RARA HUMAN Tazarotene

Approved Approved Retinoic acid re- Retinoic acid re- Retinoic acid receptor RXR-beta ceptor RXR-alpha ceptor alpha Drug-target pairs: R3 6

2985 Target 730 DB00523 2993 Target 409 DB00799 3001 Target 409 DB00459

RARA HUMAN Alitretinoin RARG2 HUMAN Tazarotene RARG2 HUMAN Acitretin

Approved Approved Approved Retinoic acid re- Retinoic acid re- Retinoic acid receptor alpha ceptor gamma-2 ceptor gamma-2

2986 Target 730 DB00982 2994 Target 409 DB02741 3002 Target 730 DB00459

RARA HUMAN Isotretinoin RARG2 HUMAN CD564 RARA HUMAN Acitretin

Approved Approved Retinoic acid re- Retinoic acid re- Retinoic acid receptor alpha ceptor gamma-2 ceptor alpha

2987 Target 229 DB00523 2995 Target 409 DB03466 3003 Target 730 DB00926

RARB HUMAN Alitretinoin RARG2 HUMAN BMS184394 RARA HUMAN Etretinate

Approved Retinoic acid re- Retinoic acid re- Retinoic acid receptor beta ceptor gamma-2 ceptor alpha

2988 Target 409 DB00523 2996 Target 409 DB00210 3004 Target 229 DB00459

RARG2 HUMAN Alitretinoin RARG2 HUMAN Adapalene RARB HUMAN Acitretin

Approved Approved Approved Retinoic acid re- Retinoic acid re- Retinoic acid receptor gamma-2 ceptor gamma-2 ceptor beta

2989 Target 409 DB00755 2997 Target 162 DB00210 3005 Target 229 DB00926

RARG2 HUMAN Tretinoin RARG1 HUMAN Adapalene RARB HUMAN Etretinate

Approved Approved Retinoic acid re- Retinoic acid re- Retinoic acid receptor gamma-2 ceptor gamma-1 ceptor beta

2990 Target 162 DB00523 2998 Target 162 DB00926 3006 Target 758 DB00451

RARG1 HUMAN Alitretinoin RARG1 HUMAN Etretinate THA HUMAN Levothyroxin e..

Approved Approved Retinoic acid re- Retinoic acid re- Thyroid hormone ceptor gamma-1 ceptor gamma-1 receptor alpha

2991 Target 162 DB00755 2999 Target 162 DB00459 3007 Target 758 DB00279

RARG1 HUMAN Tretinoin RARG1 HUMAN Acitretin THA HUMAN Liothyronine

Approved Approved Approved Retinoic acid re- Retinoic acid re- Thyroid hormone ceptor gamma-1 ceptor gamma-1 receptor alpha

2992 Target 162 DB00799 3000 Target 409 DB00926 3008 Target 346 DB00279

RARG1 HUMAN Tazarotene RARG2 HUMAN Etretinate THB1 HUMAN Liothyronine

Approved Approved Retinoic acid re- Retinoic acid re- Thyroid hormone ceptor gamma-1 ceptor gamma-2 receptor beta-1 Drug-target pairs: R3 7

3009 Target 346 DB00451 3017 Target 49 DB00559 3025 Target 488 DB00775

THB1 HUMAN Levothyroxin EDNRB HUMAN Bosentan ITA2B HUMAN Tirofiban e..

Approved Approved Approved Thyroid hormone Endothelin B re- Integrin alpha-IIb receptor beta-1 ceptor precursor precursor

3010 Target 156 DB00279 3018 Target 578 DB00559 3026 Target 136 DB01065

THB2 HUMAN Liothyronine EDNRA HUMAN Bosentan ESR1 HUMAN Melatonin

Approved Approved Approved Thyroid hormone Endothelin-1 Estrogen receptor receptor beta-2 receptor precursor

3011 Target 116 DB00451 3019 Target 106 DB00486 3027 Target 136 DB00481

CRYM HUMAN Levothyroxin CNR2 HUMAN Nabilone ESR1 HUMAN Raloxifene e..

Approved Approved Approved Mu-crystallin ho- Cannabinoid Estrogen receptor molog receptor 2

3012 Target 618 DB00120 3020 Target 2202 DB00655 3028 Target 136 DB00882

SYFB HUMAN L-Phenylalan STS HUMAN Estrone ESR1 HUMAN Clomifene ine..

Approved Approved Approved Phenylalanyl- Steryl-sulfatase Estrogen receptor tRNA synthetase precursor beta chain

3013 Target 1636 DB00182 3021 Target 1274 DB00675 3029 Target 136 DB00539

TAAR1 HUMAN Amphetamine HYES HUMAN Tamoxifen ESR1 HUMAN Toremifene

Approved Approved Approved Trace amine- Epoxide hydrolase Estrogen receptor associated 2 receptor 1

3014 Target 763 DB00120 3022 Target 2039 DB00775 3030 Target 136 DB00675

ATTY HUMAN L-Phenylalan ITB3 HUMAN Tirofiban ESR1 HUMAN Tamoxifen ine..

Approved Approved Approved Tyrosine amino- Integrin beta-3 Estrogen receptor transferase precursor

3015 Target 763 DB00135 3023 Target 2058 DB00775 3031 Target 136 DB00269

ATTY HUMAN L-Tyrosine LYAM3 HUMAN Tirofiban ESR1 HUMAN Chlorotriani sene..

Approved Approved Approved Tyrosine amino- P-selectin precur- Estrogen receptor transferase sor

3016 Target 3937 DB00818 3024 Target 2005 DB00775 3032 Target 136 DB00255

FAAH HUMAN Propofol ITA11 HUMAN Tirofiban ESR1 HUMAN Diethylstilb estrol..

Approved Approved Approved Fatty-acid amide Integrin alpha-11 Estrogen receptor hydrolase precursor Drug-target pairs: R3 8

3033 Target 136 DB00890 3041 Target 136 DB01196 3049 Target 294 DB00616

ESR1 HUMAN Dienestrol ESR1 HUMAN Estramustine NEP HUMAN Candoxatril

Approved Approved Approved Estrogen receptor Estrogen receptor Neprilysin

3034 Target 136 DB04573 3042 Target 136 DB01183 3050 Target 294 DB01654

ESR1 HUMAN Estriol ESR1 HUMAN Naloxone NEP HUMAN Thiorphan

Approved Approved Estrogen receptor Estrogen receptor Neprilysin

3035 Target 136 DB00977 3043 Target 136 DB01006 3051 Target 1502 DB00605

ESR1 HUMAN Ethinyl Estr ESR1 HUMAN Letrozole PPARD HUMAN Sulindac adiol..

Approved Approved Approved Estrogen receptor Estrogen receptor Peroxisome proliferator- activated receptor delta

3036 Target 136 DB00947 3044 Target 869 DB00783 3052 Target 1502 DB00374

ESR1 HUMAN Fulvestrant ESR2 HUMAN Estradiol PPARD HUMAN Treprostinil

Approved Approved Approved Estrogen receptor Estrogen receptor Peroxisome beta proliferator- activated receptor delta

3037 Target 136 DB00783 3045 Target 869 DB01196 3053 Target 4076 DB00163

ESR1 HUMAN Estradiol ESR2 HUMAN Estramustine DGKA HUMAN Vitamin E

Approved Approved Approved Estrogen receptor Estrogen receptor Diacylglycerol ki- beta nase alpha

3038 Target 136 DB00655 3046 Target 869 DB00675 3054 Target 2445 DB00255

ESR1 HUMAN Estrone ESR2 HUMAN Tamoxifen ERR3 RAT Diethylstilb estrol..

Approved Approved Approved Estrogen receptor Estrogen receptor Estrogen-related beta receptor gamma

3039 Target 136 DB01357 3047 Target 869 DB00481 3055 Target 3809 DB00255

ESR1 HUMAN Mestranol ESR2 HUMAN Raloxifene ERR3 HUMAN Diethylstilb estrol..

Approved Approved Approved Estrogen receptor Estrogen receptor Estrogen-related beta receptor gamma

3040 Target 136 DB04575 3048 Target 126 DB00756 3056 Target 1970 DB00163

ESR1 HUMAN Quinestrol DLD ECOLI Hexachloroph KPCA HUMAN Vitamin E ene..

Approved Approved Approved Estrogen receptor D-lactate Protein kinase C dehydrogenase alpha type Drug-target pairs: R3 9

3057 Target 997 DB00163 3065 Target 2595 DB03496 3073 Target 1656 DB01173

KPCB HUMAN Vitamin E PYGM RABIT Flavopiridol Q14097 HUMAN Orphenadrine

Approved Approved Protein kinase C Glycogen phos- CYP2B protein beta type phorylase, muscle form

3058 Target 259 DB01094 3066 Target 3968 DB03496 3074 Target 761 DB00639

MTP HUMAN Hesperetin CDK8 HUMAN Flavopiridol CP51 CANGA Butoconazole

Approved Approved Microsomal Cell division pro- Cytochrome P450 triglyceride tein kinase 8 51 transfer protein large subunit precursor

3059 Target 117 DB01094 3067 Target 137 DB00440 3075 Target 761 DB01110

SOAT1 HUMAN Hesperetin FOLC ECOLI Trimethoprim CP51 CANGA Miconazole

Approved Approved Approved Sterol O- FolC bifunctional Cytochrome P450 acyltransferase protein [Includes: 51 1 Folylpolygluta- mate synthase

3060 Target 69 DB01094 3068 Target 312 DB00400 3076 Target 249 DB01153

Q7TQM4 RAT Hesperetin TBB CANAL Griseofulvin CP51 YEAST Sertaconazol e..

Approved Approved Approved Acyl-coenzyme Tubulin beta Cytochrome P450 A:cholesterol chain 51 acyltransferase-2

3061 Target 712 DB00400 3069 Target 1898 DB00655 3077 Target 249 DB01127

TBA CANAL Griseofulvin CP1B1 HUMAN Estrone CP51 YEAST Econazole

Approved Approved Approved Tubulin alpha Cytochrome P450 Cytochrome P450 chain 1B1 51

3062 Target 714 DB01644 3070 Target 805 DB00648 3078 Target 249 DB01007

GSHR HUMAN 3,6-Dihydrox C11B1 HUMAN Mitotane CP51 YEAST Tioconazole y-Xant..

Approved Approved Glutathione Cytochrome Cytochrome P450 reductase, mi- P450 11B1, 51 tochondrial mitochondrial precursor precursor

3063 Target 250 DB01218 3071 Target 232 DB00648 3079 Target 249 DB00196

VATA PLAF7 Halofantrine CBG HUMAN Mitotane CP51 YEAST Fluconazole

Approved Approved Approved Vacuolar ATP Corticosteroid- Cytochrome P450 synthase catalytic binding globulin 51 subunit A precursor

3064 Target 3950 DB03496 3072 Target 1227 DB01117 3080 Target 249 DB00582

CDK9 HUMAN Flavopiridol CYB HUMAN Atovaquone CP51 YEAST Voriconazole

Approved Approved Cell division pro- Cytochrome b Cytochrome P450 tein kinase 9 51 Drug-target pairs: R3 10

3081 Target 249 DB00257 3089 Target 4110 DB00661 3097 Target 31 DB00120

CP51 YEAST Clotrimazole CACB2 HUMAN Verapamil SYFM HUMAN L-Phenylalan ine..

Approved Approved Approved Cytochrome P450 Voltage- Phenylalanyl- 51 dependent tRNA synthetase, L-type calcium mitochondrial channel subunit precursor beta-2

3082 Target 872 DB00292 3090 Target 333 DB00661 3098 Target 2457 DB01935

GBRA1 HUMAN Etomidate CACB1 HUMAN Verapamil NPRS BACST 3-([(1r)-1-B enzyl-..

Approved Approved Gamma- Voltage- Bacillolysin aminobutyric-acid dependent precursor receptor subunit L-type calcium alpha-1 precursor channel subunit beta-1

3083 Target 872 DB00849 3091 Target 4112 DB00661 3099 Target 18 DB00895

GBRA1 HUMAN Methylphenob CACB4 HUMAN Verapamil FCERA HUMAN Benzylpenici arbita.. lloyl ..

Approved Approved Approved Gamma- Voltage- High affinity aminobutyric-acid dependent immunoglobulin receptor subunit L-type calcium epsilon receptor alpha-1 precursor channel subunit alpha-subunit beta-4 precursor

3084 Target 872 DB01174 3092 Target 4114 DB00661 3100 Target 1820 DB01407

GBRA1 HUMAN Phenobarbita CACB3 HUMAN Verapamil NGF HUMAN Clenbuterol l..

Approved Approved Approved Gamma- Voltage- Beta-nerve growth aminobutyric-acid dependent factor precursor receptor subunit L-type calcium alpha-1 precursor channel subunit beta-3

3085 Target 872 DB00794 3093 Target 333 DB00308 3101 Target 2808 DB00446

GBRA1 HUMAN Primidone CACB1 HUMAN Ibutilide CAT3 ECOLI Chlorampheni col..

Approved Approved Approved Gamma- Voltage- Chloramphenicol aminobutyric-acid dependent acetyltransferase receptor subunit L-type calcium 3 alpha-1 precursor channel subunit beta-1

3086 Target 872 DB00818 3094 Target 333 DB01388 3102 Target 1196 DB00446

GBRA1 HUMAN Propofol CACB1 HUMAN Mibefradil DAF HUMAN Chlorampheni col..

Approved Approved Gamma- Voltage- Complement aminobutyric-acid dependent decay-accelerating receptor subunit L-type calcium factor precursor alpha-1 precursor channel subunit beta-1

3087 Target 256 DB00135 3095 Target 2478 DB01147 3103 Target 1017 DB01076

SYYC HUMAN L-Tyrosine AMPC ECOLI Cloxacillin CRP HUMAN Atorvastatin

Approved Approved Approved Tyrosyl-tRNA Beta-lactamase C-reactive protein synthetase, precursor precursor [Con- cytoplasmic tains: C-reactive protein(1-205)]

3088 Target 42 DB00120 3096 Target 4681 DB04713 3104 Target 1017 DB01393

SYFA HUMAN L-Phenylalan APX STRGR 4-IODOPHENYL CRP HUMAN Bezafibrate ine.. ALANIN..

Approved Approved Phenylalanyl- Aminopeptidase C-reactive protein tRNA synthetase precursor [Con- alpha chain tains: C-reactive protein(1-205)] Drug-target pairs: R3 11

3105 Target 963 DB01393 3113 Target 778 DB00471 3121 Target 676 DB00765

PANK1 HUMAN Bezafibrate CLTR1 HUMAN Montelukast TY3H HUMAN Metyrosine

Approved Approved Approved Pantothenate Cysteinyl Tyrosine 3- kinase 1 leukotriene monooxygenase receptor 1

3106 Target 2091 DB00615 3114 Target 778 DB01025 3122 Target 676 DB00135

ENPL HUMAN Rifabutin CLTR1 HUMAN Amlexanox TY3H HUMAN L-Tyrosine

Approved Approved Approved Endoplasmin pre- Cysteinyl Tyrosine 3- cursor leukotriene monooxygenase receptor 1

3107 Target 1787 DB01411 3115 Target 571 DB01065 3123 Target 676 DB00120

NFKB1 HUMAN Pranlukast MTR1A HUMAN Melatonin TY3H HUMAN L-Phenylalan ine..

Approved Approved Approved Nuclear factor Melatonin Tyrosine 3- NF-kappa-B p105 receptor type 1A monooxygenase subunit

3108 Target 1787 DB01041 3116 Target 571 DB00980 3124 Target 828 DB00120

NFKB1 HUMAN Thalidomide MTR1A HUMAN Ramelteon PH4H HUMAN L-Phenylalan ine..

Approved Approved Approved Nuclear factor Melatonin Phenylalanine-4- NF-kappa-B p105 receptor type 1A hydroxylase subunit

3109 Target 778 DB00587 3117 Target 362 DB00980 3125 Target 828 DB01235

CLTR1 HUMAN Cinalukast MTR1B HUMAN Ramelteon PH4H HUMAN Levodopa

Approved Approved Approved Cysteinyl Melatonin Phenylalanine-4- leukotriene receptor type 1B hydroxylase receptor 1

3110 Target 778 DB00716 3118 Target 1457 DB00197 3126 Target 828 DB06262

CLTR1 HUMAN Nedocromil ACSL4 HUMAN Troglitazone PH4H HUMAN Droxidopa

Approved Approved Cysteinyl Long-chain-fatty- Phenylalanine-4- leukotriene acid–CoA ligase hydroxylase receptor 1 4

3111 Target 778 DB01411 3119 Target 3379 DB03996 3127 Target 828 DB00368

CLTR1 HUMAN Pranlukast KIF11 HUMAN 3-[(5s)-1-Ac PH4H HUMAN Norepinephri etyl-3.. ne..

Approved Approved Cysteinyl Kinesin-like Phenylalanine-4- leukotriene protein KIF11 hydroxylase receptor 1

3112 Target 778 DB00549 3120 Target 2042 DB04612 3128 Target 828 DB00668

CLTR1 HUMAN Zafirlukast BIRC4 HUMAN N-METHYLALAN PH4H HUMAN Epinephrine YL-3-M..

Approved Approved Cysteinyl Baculoviral IAP Phenylalanine-4- leukotriene repeat-containing hydroxylase receptor 1 protein 4 Drug-target pairs: R3 12

3129 Target 594 DB00279 3137 Target 748 DB00914 3145 Target 550 DB00384

THBG HUMAN Liothyronine AAPK1 HUMAN Phenformin SCNND HUMAN Triamterene

Approved Approved Approved Thyroxine- 5’-AMP-activated Amiloride- binding globulin protein kinase sensitive sodium precursor catalytic subunit channel subunit alpha-1 delta

3130 Target 594 DB00451 3138 Target 3126 DB03509 3146 Target 837 DB00949

THBG HUMAN Levothyroxin PARP1 HUMAN 2-(4-Chlorop NMDE1 HUMAN Felbamate e.. henyl)..

Approved Approved Thyroxine- Poly [ADP-ribose] Glutamate binding globulin polymerase 1 [NMDA] receptor precursor subunit epsilon 1 precursor

3131 Target 399 DB00135 3139 Target 620 DB00205 3147 Target 464 DB00949

SYYM HUMAN L-Tyrosine DRTS PLAFK Pyrimethamin NMDE2 HUMAN Felbamate e..

Approved Approved Approved Tyrosyl-tRNA Bifunctional Glutamate synthetase, dihydrofolate [NMDA] receptor mitochondrial reductase- subunit epsilon 2 precursor thymidylate precursor synthase

3132 Target 3330 DB01235 3140 Target 457 DB00440 3148 Target 610 DB01003

PAOX ARTGO Levodopa DRTS PLABA Trimethoprim KCMA1 HUMAN Cromoglicate

Approved Approved Approved Phenylethylamine Bifunctional Calcium-activated oxidase precursor dihydrofolate potassium channel reductase- subunit alpha 1 thymidylate synthase

3133 Target 2222 DB00197 3141 Target 153 DB00988 3149 Target 535 DB00909

S29A1 HUMAN Troglitazone DOPO HUMAN Dopamine CAC1G HUMAN Zonisamide

Approved Approved Equilibrative Dopamine beta- Voltage- nucleoside hydroxylase dependent transporter 1 precursor T-type calcium channel subunit alpha-1G

3134 Target 298 DB01258 3142 Target 27 DB00384 3150 Target 158 DB00909

RENI HUMAN Aliskiren SCNNB HUMAN Triamterene SCN1A HUMAN Zonisamide

Approved Approved Approved Renin precursor Amiloride- Sodium channel sensitive sodium protein type 1 channel subunit subunit alpha beta

3135 Target 298 DB03395 3143 Target 552 DB00384 3151 Target 2927 DB04638

RENI HUMAN Enalkiren SCNNG HUMAN Triamterene AT2A1 RABIT 2,5-DI-(TERT -BUTYL..

Approved Renin precursor Amiloride- Sarcoplasmic/endoplasmic sensitive sodium reticulum calcium channel gamma- ATPase 1 subunit

3136 Target 298 DB00212 3144 Target 213 DB00384 3152 Target 776 DB00559

RENI HUMAN Remikiren SCNNA HUMAN Triamterene ABCBB HUMAN Bosentan

Approved Approved Approved Renin precursor Amiloride- Bile salt export sensitive sodium pump channel subunit alpha Drug-target pairs: R3 13

3153 Target 776 DB01016 3161 Target 779 DB00920 3169 Target 3127 DB03317

ABCBB HUMAN Glibenclamid PDE7A HUMAN Ketotifen NIRS PSEAE Heme C e..

Approved Approved Bile salt export High-affinity Nitrite reductase pump cAMP-specific precursor 3’,5’-cyclic phosphodiesterase 7A

3154 Target 485 DB04880 3162 Target 2549 DB00674 3170 Target 3284 DB03317

PDE3A HUMAN Enoximone ACES TORCA Galantamine NIRS PARPN Heme C

Approved Approved cGMP-inhibited Acetylcholinesterase Nitrite reductase 3’,5’-cyclic phos- precursor precursor phodiesterase A

3155 Target 241 DB01110 3163 Target 2549 DB04614 3171 Target 3405 DB03317

AT2C1 HUMAN Miconazole ACES TORCA (R)-tacrine( QHED COMTE Heme C 10)-hu..

Approved Calcium- Acetylcholinesterase Quinohaemoprotein transporting precursor ethanol dehydro- ATPase type 2C genase type-1 member 1 precursor

3156 Target 3811 DB00357 3164 Target 2549 DB04615 3172 Target 4757 DB03317

CP19A HUMAN Aminogluteth ACES TORCA (S)-tacrine( CP2C9 HUMAN Heme C imide.. 10)-hu..

Approved Cytochrome P450 Acetylcholinesterase Cytochrome P450 19A1 precursor 2C9

3157 Target 3811 DB01006 3165 Target 2549 DB04616 3173 Target 4986 DB03014

CP19A HUMAN Letrozole ACES TORCA TACRINE(8)-4 CP2C5 RABIT Heme -AMINO..

Approved Cytochrome P450 Acetylcholinesterase Cytochrome P450 19A1 precursor 2C5

3158 Target 3811 DB01217 3166 Target 2549 DB04617 3174 Target 4757 DB03014

CP19A HUMAN Anastrozole ACES TORCA (9S)-9-[(8-A CP2C9 HUMAN Heme MMONIO..

Approved Cytochrome P450 Acetylcholinesterase Cytochrome P450 19A1 precursor 2C9

3159 Target 1086 DB00321 3167 Target 2549 DB01928 3175 Target 4924 DB03014

KCNQ2 HUMAN Amitriptylin ACES TORCA Huperaine A CP2C8 HUMAN Heme e..

Approved Potassium Acetylcholinesterase Cytochrome P450 voltage-gated precursor 2C8 channel subfamily KQT member 2

3160 Target 691 DB00920 3168 Target 3458 DB02832 3176 Target 2337 DB03014

PDE7B HUMAN Ketotifen CYSI ECOLI Siroheme NOS3 BOVIN Heme

Approved cAMP-specific Sulfite reduc- Nitric-oxide syn- 3’,5’-cyclic phos- tase [NADPH] thase, endothelial phodiesterase hemoprotein 7B beta-component Drug-target pairs: R3 14

3177 Target 291 DB03014 3185 Target 239 DB00170 3193 Target 541 DB01166

NOS3 HUMAN Heme FA10 HUMAN Menadione PDE4B HUMAN Cilostazol

Approved Approved Nitric-oxide syn- Coagulation cAMP-specific thase, endothelial factor X precursor 3’,5’-cyclic phosphodiesterase 4B

3178 Target 291 DB01098 3186 Target 239 DB04673 3194 Target 54 DB02351

NOS3 HUMAN Rosuvastatin FA10 HUMAN 4-[(5-CHLORO THRB HUMAN Hirulog INDOL-..

Approved Nitric-oxide syn- Coagulation Prothrombin pre- thase, endothelial factor X precursor cursor

3179 Target 1694 DB01258 3187 Target 1971 DB00692 3195 Target 54 DB04697

ANGT HUMAN Aliskiren PDE4A HUMAN Phentolamine THRB HUMAN TRANS-4-(GUA NIDINO..

Approved Approved Angiotensinogen cAMP-specific Prothrombin pre- precursor 3’,5’-cyclic phos- cursor phodiesterase 4A

3180 Target 1694 DB00722 3188 Target 1971 DB01166 3196 Target 54 DB00682

ANGT HUMAN Lisinopril PDE4A HUMAN Cilostazol THRB HUMAN Warfarin

Approved Approved Approved Angiotensinogen cAMP-specific Prothrombin pre- precursor 3’,5’-cyclic phos- cursor phodiesterase 4A

3181 Target 1694 DB01029 3189 Target 1971 DB00820 3197 Target 54 DB00170

ANGT HUMAN Irbesartan PDE4A HUMAN Tadalafil THRB HUMAN Menadione

Approved Approved Approved Angiotensinogen cAMP-specific Prothrombin pre- precursor 3’,5’-cyclic phos- cursor phodiesterase 4A

3182 Target 1694 DB01076 3190 Target 1971 DB01088 3198 Target 54 DB01123

ANGT HUMAN Atorvastatin PDE4A HUMAN Iloprost THRB HUMAN Proflavine

Approved Approved Approved Angiotensinogen cAMP-specific Prothrombin pre- precursor 3’,5’-cyclic phos- cursor phodiesterase 4A

3183 Target 134 DB00150 3191 Target 541 DB01647 3199 Target 54 DB04786

TPH1 HUMAN L-Tryptophan PDE4B HUMAN (R)-Mesopram THRB HUMAN Suramin

Approved Approved Tryptophan cAMP-specific Prothrombin pre- 5-hydroxylase 1 3’,5’-cyclic phos- cursor phodiesterase 4B

3184 Target 90 DB00150 3192 Target 541 DB01113 3200 Target 54 DB04722

TPH2 HUMAN L-Tryptophan PDE4B HUMAN Papaverine THRB HUMAN 2-(3-CHLORO- 6-([2,..

Approved Approved Tryptophan cAMP-specific Prothrombin pre- 5-hydroxylase 2 3’,5’-cyclic phos- cursor phodiesterase 4B Drug-target pairs: R3 15

3201 Target 54 DB04591 3209 Target 766 DB00960 3217 Target 766 DB00668

THRB HUMAN N-(2,2-DIFLU ADRB2 HUMAN Pindolol ADRB2 HUMAN Epinephrine ORO-2-..

Approved Approved Prothrombin pre- Beta-2 adrenergic Beta-2 adrenergic cursor receptor receptor

3202 Target 54 DB00278 3210 Target 766 DB00571 3218 Target 766 DB01001

THRB HUMAN Argatroban ADRB2 HUMAN Propranolol ADRB2 HUMAN Salbutamol

Approved Approved Approved Prothrombin pre- Beta-2 adrenergic Beta-2 adrenergic cursor receptor receptor

3203 Target 54 DB04771 3211 Target 766 DB00866 3219 Target 766 DB00871

THRB HUMAN 1-GUANIDINO- ADRB2 HUMAN Alprenolol ADRB2 HUMAN Terbutaline 4-(N-N..

Approved Approved Prothrombin pre- Beta-2 adrenergic Beta-2 adrenergic cursor receptor receptor

3204 Target 54 DB04898 3212 Target 766 DB01359 3220 Target 766 DB01064

THRB HUMAN Ximelagatran ADRB2 HUMAN Penbutolol ADRB2 HUMAN Isoprotereno l..

Approved Approved Approved Prothrombin pre- Beta-2 adrenergic Beta-2 adrenergic cursor receptor receptor

3205 Target 54 DB04772 3213 Target 766 DB01210 3221 Target 766 DB00816

THRB HUMAN 1-GUANIDINO- ADRB2 HUMAN Levobunolol ADRB2 HUMAN Orciprenalin 4-(N-P.. e..

Approved Approved Prothrombin pre- Beta-2 adrenergic Beta-2 adrenergic cursor receptor receptor

3206 Target 766 DB01158 3214 Target 766 DB01203 3222 Target 766 DB01408

ADRB2 HUMAN Bretylium ADRB2 HUMAN Nadolol ADRB2 HUMAN Bambuterol

Approved Approved Approved Beta-2 adrenergic Beta-2 adrenergic Beta-2 adrenergic receptor receptor receptor

3207 Target 766 DB01214 3215 Target 766 DB06262 3223 Target 766 DB00901

ADRB2 HUMAN Metipranolol ADRB2 HUMAN Droxidopa ADRB2 HUMAN Bitolterol

Approved Approved Beta-2 adrenergic Beta-2 adrenergic Beta-2 adrenergic receptor receptor receptor

3208 Target 766 DB00612 3216 Target 766 DB00368 3224 Target 766 DB00598

ADRB2 HUMAN Bisoprolol ADRB2 HUMAN Norepinephri ADRB2 HUMAN Labetalol ne..

Approved Approved Approved Beta-2 adrenergic Beta-2 adrenergic Beta-2 adrenergic receptor receptor receptor Drug-target pairs: R3 16

3225 Target 766 DB00938 3233 Target 766 DB01136 3241 Target 193 DB00335

ADRB2 HUMAN Salmeterol ADRB2 HUMAN Carvedilol ADRB1 HUMAN Atenolol

Approved Approved Approved Beta-2 adrenergic Beta-2 adrenergic Beta-1 adrenergic receptor receptor receptor

3226 Target 766 DB01288 3234 Target 766 DB00521 3242 Target 193 DB00988

ADRB2 HUMAN Fenoterol ADRB2 HUMAN Carteolol ADRB1 HUMAN Dopamine

Approved Approved Approved Beta-2 adrenergic Beta-2 adrenergic Beta-1 adrenergic receptor receptor receptor

3227 Target 766 DB00867 3235 Target 766 DB01151 3243 Target 193 DB00368

ADRB2 HUMAN Ritodrine ADRB2 HUMAN Desipramine ADRB1 HUMAN Norepinephri ne..

Approved Approved Approved Beta-2 adrenergic Beta-2 adrenergic Beta-1 adrenergic receptor receptor receptor

3228 Target 766 DB00852 3236 Target 193 DB00246 3244 Target 193 DB00668

ADRB2 HUMAN Pseudoephedr ADRB1 HUMAN Ziprasidone ADRB1 HUMAN Epinephrine ine..

Approved Approved Approved Beta-2 adrenergic Beta-1 adrenergic Beta-1 adrenergic receptor receptor receptor

3229 Target 766 DB01407 3237 Target 193 DB01151 3245 Target 193 DB01064

ADRB2 HUMAN Clenbuterol ADRB1 HUMAN Desipramine ADRB1 HUMAN Isoprotereno l..

Approved Approved Approved Beta-2 adrenergic Beta-1 adrenergic Beta-1 adrenergic receptor receptor receptor

3230 Target 766 DB00983 3238 Target 193 DB00521 3246 Target 193 DB01295

ADRB2 HUMAN Formoterol ADRB1 HUMAN Carteolol ADRB1 HUMAN Bevantolol

Approved Approved Approved Beta-2 adrenergic Beta-1 adrenergic Beta-1 adrenergic receptor receptor receptor

3231 Target 766 DB01274 3239 Target 193 DB01193 3247 Target 193 DB00598

ADRB2 HUMAN Arformoterol ADRB1 HUMAN Acebutolol ADRB1 HUMAN Labetalol

Approved Approved Approved Beta-2 adrenergic Beta-1 adrenergic Beta-1 adrenergic receptor receptor receptor

3232 Target 766 DB01366 3240 Target 193 DB01136 3248 Target 193 DB00841

ADRB2 HUMAN Procaterol ADRB1 HUMAN Carvedilol ADRB1 HUMAN Dobutamine

Approved Approved Approved Beta-2 adrenergic Beta-1 adrenergic Beta-1 adrenergic receptor receptor receptor Drug-target pairs: R3 17

3249 Target 193 DB00221 3257 Target 193 DB00734 3265 Target 193 DB01158

ADRB1 HUMAN Isoetharine ADRB1 HUMAN Risperidone ADRB1 HUMAN Bretylium

Approved Approved Approved Beta-1 adrenergic Beta-1 adrenergic Beta-1 adrenergic receptor receptor receptor

3250 Target 193 DB01102 3258 Target 193 DB00264 3266 Target 1517 DB00960

ADRB1 HUMAN Arbutamine ADRB1 HUMAN Metoprolol ADRB3 HUMAN Pindolol

Approved Approved Approved Beta-1 adrenergic Beta-1 adrenergic Beta-3 adrenergic receptor receptor receptor

3251 Target 193 DB06262 3259 Target 193 DB00195 3267 Target 1517 DB00571

ADRB1 HUMAN Droxidopa ADRB1 HUMAN Betaxolol ADRB3 HUMAN Propranolol

Approved Approved Approved Beta-1 adrenergic Beta-1 adrenergic Beta-3 adrenergic receptor receptor receptor

3252 Target 193 DB00187 3260 Target 193 DB00866 3268 Target 1517 DB00368

ADRB1 HUMAN Esmolol ADRB1 HUMAN Alprenolol ADRB3 HUMAN Norepinephri ne..

Approved Approved Approved Beta-1 adrenergic Beta-1 adrenergic Beta-3 adrenergic receptor receptor receptor

3253 Target 193 DB01359 3261 Target 193 DB00571 3269 Target 1517 DB06262

ADRB1 HUMAN Penbutolol ADRB1 HUMAN Propranolol ADRB3 HUMAN Droxidopa

Approved Approved Approved Beta-1 adrenergic Beta-1 adrenergic Beta-3 adrenergic receptor receptor receptor

3254 Target 193 DB01210 3262 Target 193 DB01214 3270 Target 1483 DB01275

ADRB1 HUMAN Levobunolol ADRB1 HUMAN Metipranolol AOC3 HUMAN Hydralazine

Approved Approved Approved Beta-1 adrenergic Beta-1 adrenergic Membrane copper receptor receptor amine oxidase

3255 Target 193 DB01203 3263 Target 193 DB00612 3271 Target 1483 DB00780

ADRB1 HUMAN Nadolol ADRB1 HUMAN Bisoprolol AOC3 HUMAN Phenelzine

Approved Approved Approved Beta-1 adrenergic Beta-1 adrenergic Membrane copper receptor receptor amine oxidase

3256 Target 193 DB01118 3264 Target 193 DB00960 3272 Target 687 DB04800

ADRB1 HUMAN Amiodarone ADRB1 HUMAN Pindolol PTN1 HUMAN 1-METHYL-3-P HENYL-..

Approved Approved Beta-1 adrenergic Beta-1 adrenergic Tyrosine-protein receptor receptor phosphatase non-receptor type 1 Drug-target pairs: R3 18

3273 Target 4656 DB04779 3281 Target 709 DB01120 3289 Target 709 DB00912

MYRA SINAL ETHYL (1E)-2 IRK1 HUMAN Gliclazide IRK1 HUMAN Repaglinide -PHENY..

Approved Approved Myrosinase MA1 ATP-sensitive ATP-sensitive inward rectifier inward rectifier potassium channel potassium channel 1 1

3274 Target 4656 DB04659 3282 Target 709 DB00839 3290 Target 20 DB00465

MYRA SINAL (1S,2S,3R,4S IRK1 HUMAN Tolazamide PGH1 HUMAN Ketorolac ,5S)-2..

Approved Approved Myrosinase MA1 ATP-sensitive Prostaglandin inward rectifier G/H synthase 1 potassium channel precursor 1

3275 Target 672 DB00654 3283 Target 709 DB01124 3291 Target 20 DB00500

PF2R HUMAN Latanoprost IRK1 HUMAN Tolbutamide PGH1 HUMAN Tolmetin

Approved Approved Approved Prostaglandin F2- ATP-sensitive Prostaglandin alpha receptor inward rectifier G/H synthase 1 potassium channel precursor 1

3276 Target 672 DB00905 3284 Target 709 DB00414 3292 Target 20 DB00554

PF2R HUMAN Bimatoprost IRK1 HUMAN Acetohexamid PGH1 HUMAN Piroxicam e..

Approved Approved Approved Prostaglandin F2- ATP-sensitive Prostaglandin alpha receptor inward rectifier G/H synthase 1 potassium channel precursor 1

3277 Target 672 DB00287 3285 Target 709 DB00731 3293 Target 20 DB00963

PF2R HUMAN Travoprost IRK1 HUMAN Nateglinide PGH1 HUMAN Bromfenac

Approved Approved Approved Prostaglandin F2- ATP-sensitive Prostaglandin alpha receptor inward rectifier G/H synthase 1 potassium channel precursor 1

3278 Target 122 DB00374 3286 Target 709 DB01067 3294 Target 20 DB00461

P2Y12 HUMAN Treprostinil IRK1 HUMAN Glipizide PGH1 HUMAN Nabumetone

Approved Approved Approved P2Y purinoceptor ATP-sensitive Prostaglandin 12 inward rectifier G/H synthase 1 potassium channel precursor 1

3279 Target 122 DB00758 3287 Target 709 DB00222 3295 Target 20 DB00605

P2Y12 HUMAN Clopidogrel IRK1 HUMAN Glimepiride PGH1 HUMAN Sulindac

Approved Approved Approved P2Y purinoceptor ATP-sensitive Prostaglandin 12 inward rectifier G/H synthase 1 potassium channel precursor 1

3280 Target 122 DB00208 3288 Target 709 DB01016 3296 Target 20 DB01009

P2Y12 HUMAN Ticlopidine IRK1 HUMAN Glibenclamid PGH1 HUMAN Ketoprofen e..

Approved Approved Approved P2Y purinoceptor ATP-sensitive Prostaglandin 12 inward rectifier G/H synthase 1 potassium channel precursor 1 Drug-target pairs: R3 19

3297 Target 20 DB01050 3305 Target 20 DB01399 3313 Target 20 DB00749

PGH1 HUMAN Ibuprofen PGH1 HUMAN Salsalate PGH1 HUMAN Etodolac

Approved Approved Approved Prostaglandin Prostaglandin Prostaglandin G/H synthase 1 G/H synthase 1 G/H synthase 1 precursor precursor precursor

3298 Target 20 DB00712 3306 Target 20 DB00936 3314 Target 20 DB00328

PGH1 HUMAN Flurbiprofen PGH1 HUMAN Salicyclic a PGH1 HUMAN Indomethacin cid..

Approved Approved Approved Prostaglandin Prostaglandin Prostaglandin G/H synthase 1 G/H synthase 1 G/H synthase 1 precursor precursor precursor

3299 Target 20 DB00870 3307 Target 20 DB00244 3315 Target 290 DB00328

PGH1 HUMAN Suprofen PGH1 HUMAN Mesalazine PGH2 HUMAN Indomethacin

Approved Approved Approved Prostaglandin Prostaglandin Prostaglandin G/H synthase 1 G/H synthase 1 G/H synthase 2 precursor precursor precursor

3300 Target 20 DB00533 3308 Target 20 DB01014 3316 Target 290 DB00749

PGH1 HUMAN Rofecoxib PGH1 HUMAN Balsalazide PGH2 HUMAN Etodolac

Approved Approved Prostaglandin Prostaglandin Prostaglandin G/H synthase 1 G/H synthase 1 G/H synthase 2 precursor precursor precursor

3301 Target 20 DB00861 3309 Target 20 DB00939 3317 Target 290 DB00586

PGH1 HUMAN Diflunisal PGH1 HUMAN Meclofenamic PGH2 HUMAN Diclofenac acid..

Approved Approved Approved Prostaglandin Prostaglandin Prostaglandin G/H synthase 1 G/H synthase 1 G/H synthase 2 precursor precursor precursor

3302 Target 20 DB00788 3310 Target 20 DB00784 3318 Target 290 DB01283

PGH1 HUMAN Naproxen PGH1 HUMAN Mefenamic ac PGH2 HUMAN Lumiracoxib id..

Approved Approved Approved Prostaglandin Prostaglandin Prostaglandin G/H synthase 1 G/H synthase 1 G/H synthase 2 precursor precursor precursor

3303 Target 20 DB00573 3311 Target 20 DB01283 3319 Target 290 DB00821

PGH1 HUMAN Fenoprofen PGH1 HUMAN Lumiracoxib PGH2 HUMAN Carprofen

Approved Approved Approved Prostaglandin Prostaglandin Prostaglandin G/H synthase 1 G/H synthase 1 G/H synthase 2 precursor precursor precursor

3304 Target 20 DB00945 3312 Target 20 DB00586 3320 Target 290 DB00784

PGH1 HUMAN Aspirin PGH1 HUMAN Diclofenac PGH2 HUMAN Mefenamic ac id..

Approved Approved Approved Prostaglandin Prostaglandin Prostaglandin G/H synthase 1 G/H synthase 1 G/H synthase 2 precursor precursor precursor Drug-target pairs: R3 20

3321 Target 290 DB00939 3329 Target 290 DB01399 3337 Target 290 DB00712

PGH2 HUMAN Meclofenamic PGH2 HUMAN Salsalate PGH2 HUMAN Flurbiprofen acid..

Approved Approved Approved Prostaglandin Prostaglandin Prostaglandin G/H synthase 2 G/H synthase 2 G/H synthase 2 precursor precursor precursor

3322 Target 290 DB00482 3330 Target 290 DB00945 3338 Target 290 DB01050

PGH2 HUMAN Celecoxib PGH2 HUMAN Aspirin PGH2 HUMAN Ibuprofen

Approved Approved Approved Prostaglandin Prostaglandin Prostaglandin G/H synthase 2 G/H synthase 2 G/H synthase 2 precursor precursor precursor

3323 Target 290 DB01041 3331 Target 290 DB00573 3339 Target 290 DB01009

PGH2 HUMAN Thalidomide PGH2 HUMAN Fenoprofen PGH2 HUMAN Ketoprofen

Approved Approved Approved Prostaglandin Prostaglandin Prostaglandin G/H synthase 2 G/H synthase 2 G/H synthase 2 precursor precursor precursor

3324 Target 290 DB00480 3332 Target 290 DB00788 3340 Target 290 DB00605

PGH2 HUMAN Lenalidomide PGH2 HUMAN Naproxen PGH2 HUMAN Sulindac

Approved Approved Approved Prostaglandin Prostaglandin Prostaglandin G/H synthase 2 G/H synthase 2 G/H synthase 2 precursor precursor precursor

3325 Target 290 DB01014 3333 Target 290 DB00861 3341 Target 290 DB00580

PGH2 HUMAN Balsalazide PGH2 HUMAN Diflunisal PGH2 HUMAN Valdecoxib

Approved Approved Prostaglandin Prostaglandin Prostaglandin G/H synthase 2 G/H synthase 2 G/H synthase 2 precursor precursor precursor

3326 Target 290 DB00991 3334 Target 290 DB00533 3342 Target 290 DB00461

PGH2 HUMAN Oxaprozin PGH2 HUMAN Rofecoxib PGH2 HUMAN Nabumetone

Approved Approved Prostaglandin Prostaglandin Prostaglandin G/H synthase 2 G/H synthase 2 G/H synthase 2 precursor precursor precursor

3327 Target 290 DB00244 3335 Target 290 DB01600 3343 Target 290 DB00963

PGH2 HUMAN Mesalazine PGH2 HUMAN Tiaprofenic PGH2 HUMAN Bromfenac acid..

Approved Approved Approved Prostaglandin Prostaglandin Prostaglandin G/H synthase 2 G/H synthase 2 G/H synthase 2 precursor precursor precursor

3328 Target 290 DB00936 3336 Target 290 DB00870 3344 Target 290 DB01628

PGH2 HUMAN Salicyclic a PGH2 HUMAN Suprofen PGH2 HUMAN Etoricoxib cid..

Approved Approved Approved Prostaglandin Prostaglandin Prostaglandin G/H synthase 2 G/H synthase 2 G/H synthase 2 precursor precursor precursor Drug-target pairs: R3 21

3345 Target 290 DB00814 3353 Target 341 DB00969 3361 Target 474 DB00843

PGH2 HUMAN Meloxicam 5HT3R HUMAN Alosetron ACES HUMAN Donepezil

Approved Approved Approved Prostaglandin 5- Acetylcholinesterase G/H synthase 2 hydroxytryptamine precursor precursor 3 receptor precursor

3346 Target 290 DB00500 3354 Target 341 DB00904 3362 Target 474 DB00572

PGH2 HUMAN Tolmetin 5HT3R HUMAN Ondansetron ACES HUMAN Atropine

Approved Approved Approved Prostaglandin 5- Acetylcholinesterase G/H synthase 2 hydroxytryptamine precursor precursor 3 receptor precursor

3347 Target 290 DB00465 3355 Target 341 DB00370 3363 Target 474 DB00989

PGH2 HUMAN Ketorolac 5HT3R HUMAN Mirtazapine ACES HUMAN Rivastigmine

Approved Approved Approved Prostaglandin 5- Acetylcholinesterase G/H synthase 2 hydroxytryptamine precursor precursor 3 receptor precursor

3348 Target 341 DB00604 3356 Target 341 DB00377 3364 Target 474 DB01364

5HT3R HUMAN Cisapride 5HT3R HUMAN Palonosetron ACES HUMAN Ephedrine

Approved Approved Approved 5- 5- Acetylcholinesterase hydroxytryptamine hydroxytryptamine precursor 3 receptor precur- 3 receptor precursor sor

3349 Target 341 DB01161 3357 Target 341 DB01199 3365 Target 474 DB00382

5HT3R HUMAN Chloroprocai 5HT3R HUMAN Tubocurarine ACES HUMAN Tacrine ne..

Approved Approved Approved 5- 5- Acetylcholinesterase hydroxytryptamine hydroxytryptamine precursor 3 receptor precur- 3 receptor precursor sor

3350 Target 341 DB00721 3358 Target 474 DB00981 3366 Target 474 DB01122

5HT3R HUMAN Procaine ACES HUMAN Physostigmin ACES HUMAN Ambenonium e..

Approved Approved Approved 5- Acetylcholinesterase Acetylcholinesterase hydroxytryptamine precursor precursor 3 receptor precursor

3351 Target 341 DB00757 3359 Target 474 DB01199 3367 Target 275 DB00744

5HT3R HUMAN Dolasetron ACES HUMAN Tubocurarine LOX5 HUMAN Zileuton

Approved Approved Approved 5- Acetylcholinesterase Arachidonate hydroxytryptamine precursor 5-lipoxygenase 3 receptor precursor

3352 Target 341 DB00889 3360 Target 474 DB00674 3368 Target 275 DB01097

5HT3R HUMAN Granisetron ACES HUMAN Galantamine LOX5 HUMAN Leflunomide

Approved Approved Approved 5- Acetylcholinesterase Arachidonate hydroxytryptamine precursor 5-lipoxygenase 3 receptor precursor Drug-target pairs: R3 22

3369 Target 275 DB00939 3377 Target 266 DB01241 3385 Target 789 DB00590

LOX5 HUMAN Meclofenamic LIPL HUMAN Gemfibrozil ADA1D HUMAN Doxazosin acid..

Approved Approved Approved Arachidonate Lipoprotein lipase Alpha-1D adren- 5-lipoxygenase precursor ergic receptor

3370 Target 275 DB01103 3378 Target 5718 DB04665 3386 Target 789 DB00457

LOX5 HUMAN Quinacrine CP2A6 HUMAN 2H-1-BENZOPY ADA1D HUMAN Prazosin RAN-2-..

Approved Approved Arachidonate Cytochrome P450 Alpha-1D adren- 5-lipoxygenase 2A6 ergic receptor

3371 Target 275 DB01017 3379 Target 5718 DB00553 3387 Target 789 DB00298

LOX5 HUMAN Minocycline CP2A6 HUMAN Methoxsalen ADA1D HUMAN Dapiprazole

Approved Approved Approved Arachidonate Cytochrome P450 Alpha-1D adren- 5-lipoxygenase 2A6 ergic receptor

3372 Target 275 DB00471 3380 Target 1490 DB01241 3388 Target 789 DB01608

LOX5 HUMAN Montelukast SO1B1 HUMAN Gemfibrozil ADA1D HUMAN Propericiazi ne..

Approved Approved Approved Arachidonate Solute carrier Alpha-1D adren- 5-lipoxygenase organic anion ergic receptor transporter family member 1B1

3373 Target 275 DB00179 3381 Target 318 DB00629 3389 Target 632 DB01608

LOX5 HUMAN Masoprocol ADA2A HUMAN Guanabenz ADA1B HUMAN Propericiazi ne..

Approved Approved Approved Arachidonate Alpha-2A adrener- Alpha-1B adrener- 5-lipoxygenase gic receptor gic receptor

3374 Target 275 DB00163 3382 Target 318 DB00692 3390 Target 632 DB00298

LOX5 HUMAN Vitamin E ADA2A HUMAN Phentolamine ADA1B HUMAN Dapiprazole

Approved Approved Approved Arachidonate Alpha-2A adrener- Alpha-1B adrener- 5-lipoxygenase gic receptor gic receptor

3375 Target 339 DB00179 3383 Target 789 DB00346 3391 Target 632 DB01224

LOX15 HUMAN Masoprocol ADA1D HUMAN Alfuzosin ADA1B HUMAN Quetiapine

Approved Approved Approved Arachidonate 15- Alpha-1D adren- Alpha-1B adrener- lipoxygenase ergic receptor gic receptor

3376 Target 339 DB00744 3384 Target 789 DB01162 3392 Target 632 DB00457

LOX15 HUMAN Zileuton ADA1D HUMAN Terazosin ADA1B HUMAN Prazosin

Approved Approved Approved Arachidonate 15- Alpha-1D adren- Alpha-1B adrener- lipoxygenase ergic receptor gic receptor Drug-target pairs: R3 23

3393 Target 632 DB00590 3401 Target 556 DB00665 3409 Target 3805 DB00555

ADA1B HUMAN Doxazosin ADA1A HUMAN Nilutamide SCN8A HUMAN Lamotrigine

Approved Approved Approved Alpha-1B adrener- Alpha-1A adrener- Sodium channel gic receptor gic receptor protein type 8 subunit alpha

3394 Target 632 DB01162 3402 Target 556 DB01608 3410 Target 3802 DB00555

ADA1B HUMAN Terazosin ADA1A HUMAN Propericiazi SCN2A HUMAN Lamotrigine ne..

Approved Approved Approved Alpha-1B adrener- Alpha-1A adrener- Sodium channel gic receptor gic receptor protein type 2 subunit alpha

3395 Target 632 DB00346 3403 Target 556 DB00831 3411 Target 3803 DB00555

ADA1B HUMAN Alfuzosin ADA1A HUMAN Trifluoperaz SCN3A HUMAN Lamotrigine ine..

Approved Approved Approved Alpha-1B adrener- Alpha-1A adrener- Sodium channel gic receptor gic receptor protein type 3 subunit alpha

3396 Target 556 DB00925 3404 Target 556 DB00298 3412 Target 158 DB00555

ADA1A HUMAN Phenoxybenza ADA1A HUMAN Dapiprazole SCN1A HUMAN Lamotrigine mine..

Approved Approved Approved Alpha-1A adrener- Alpha-1A adrener- Sodium channel gic receptor gic receptor protein type 1 subunit alpha

3397 Target 556 DB00457 3405 Target 706 DB00721 3413 Target 1995 DB00555

ADA1A HUMAN Prazosin NMD3A HUMAN Procaine SCN9A HUMAN Lamotrigine

Approved Approved Approved Alpha-1A adrener- Glutamate Sodium channel gic receptor [NMDA] receptor protein type 9 subunit 3A subunit alpha precursor

3398 Target 556 DB00590 3406 Target 706 DB01161 3414 Target 814 DB01219

ADA1A HUMAN Doxazosin NMD3A HUMAN Chloroprocai RYR1 HUMAN Dantrolene ne..

Approved Approved Approved Alpha-1A adrener- Glutamate Ryanodine recep- gic receptor [NMDA] receptor tor 1 subunit 3A precursor

3399 Target 556 DB01162 3407 Target 3804 DB00555 3415 Target 198 DB00892

ADA1A HUMAN Terazosin SCN4A HUMAN Lamotrigine SC10A HUMAN Oxybuprocain e..

Approved Approved Approved Alpha-1A adrener- Sodium channel Sodium channel gic receptor protein type 4 protein type 10 subunit alpha subunit alpha

3400 Target 556 DB00346 3408 Target 220 DB00555 3416 Target 198 DB00807

ADA1A HUMAN Alfuzosin SCN5A HUMAN Lamotrigine SC10A HUMAN Proparacaine

Approved Approved Approved Alpha-1A adrener- Sodium channel Sodium channel gic receptor protein type 5 protein type 10 subunit alpha subunit alpha Drug-target pairs: R3 24

3417 Target 198 DB00721 3425 Target 220 DB00379 3433 Target 862 DB01032

SC10A HUMAN Procaine SCN5A HUMAN Mexiletine MRP1 HUMAN Probenecid

Approved Approved Approved Sodium channel Sodium channel Multidrug protein type 10 protein type 5 resistance- subunit alpha subunit alpha associated protein 1

3418 Target 198 DB01161 3426 Target 2 DB00507 3434 Target 230 DB01120

SC10A HUMAN Chloroprocai PNO CRYPV Nitazoxanide ABCC8 HUMAN Gliclazide ne..

Approved Approved Approved Sodium channel Pyruvate dehydro- ATP-binding cas- protein type 10 genase [NADP+] sette transporter subunit alpha sub-family C member 8

3419 Target 198 DB01086 3427 Target 3160 DB03647 3435 Target 23 DB00907

SC10A HUMAN Benzocaine POLG HCVJ6 3-[Isopropyl DRD1 HUMAN Cocaine (4-Met..

Approved Approved Sodium channel Genome polypro- D(1A) dopamine protein type 10 tein [Contains: receptor subunit alpha Core protein p21

3420 Target 198 DB00473 3428 Target 3160 DB03388 3436 Target 23 DB00508

SC10A HUMAN Hexylcaine POLG HCVJ6 3-[(2,4-Dich DRD1 HUMAN Triflupromaz lorobe.. ine..

Approved Approved Sodium channel Genome polypro- D(1A) dopamine protein type 10 tein [Contains: receptor subunit alpha Core protein p21

3421 Target 198 DB00907 3429 Target 2297 DB01720 3437 Target 23 DB00623

SC10A HUMAN Cocaine POLG HCVJA (2z)-2-(Benz DRD1 HUMAN Fluphenazine oylami..

Approved Approved Sodium channel Genome polypro- D(1A) dopamine protein type 10 tein [Contains: receptor subunit alpha Core protein p21

3422 Target 215 DB00907 3430 Target 220 DB01195 3438 Target 23 DB01224

SC11A HUMAN Cocaine SCN5A HUMAN Flecainide DRD1 HUMAN Quetiapine

Approved Approved Approved Sodium channel Sodium channel D(1A) dopamine protein type 11 protein type 5 receptor subunit alpha subunit alpha

3423 Target 220 DB00907 3431 Target 5407 DB04595 3439 Target 23 DB00408

SCN5A HUMAN Cocaine R1AB CVHSA (E)-(4S,6S)- DRD1 HUMAN Loxapine 8-METH..

Approved Approved Sodium channel Replicase polypro- D(1A) dopamine protein type 5 tein 1ab receptor subunit alpha

3424 Target 220 DB00473 3432 Target 5726 DB04634 3440 Target 2328 DB04599

SCN5A HUMAN Hexylcaine POLG HAVMB N-BENZYLOXYC GRIA2 RAT Aniracetam ARBONY..

Approved Sodium channel Genome polypro- Glutamate recep- protein type 5 tein tor 2 precursor subunit alpha Drug-target pairs: R3 25

3441 Target 3806 DB00203 3449 Target 467 DB01444 3457 Target 3939 DB01367

PDE2A HUMAN Sildenafil OPRD HUMAN Dimethylthia AOFB HUMAN Rasagiline mbuten..

Approved Approved cGMP-dependent Delta-type opioid Amine oxidase 3’,5’-cyclic receptor [flavin-containing] phosphodiesterase B

3442 Target 204 DB06267 3450 Target 3939 DB01247 3458 Target 3941 DB00830

PDE5A HUMAN Udenafil AOFB HUMAN Isocarboxazi AOFA HUMAN Phenmetrazin d.. e..

Approved Approved Approved cGMP-specific Amine oxidase Amine oxidase 3’,5’-cyclic [flavin-containing] [flavin-containing] phosphodiesterase B A

3443 Target 204 DB00203 3451 Target 3939 DB00934 3459 Target 3941 DB00752

PDE5A HUMAN Sildenafil AOFB HUMAN Maprotiline AOFA HUMAN Tranylcyprom ine..

Approved Approved Approved cGMP-specific Amine oxidase Amine oxidase 3’,5’-cyclic [flavin-containing] [flavin-containing] phosphodiesterase B A

3444 Target 204 DB00862 3452 Target 3939 DB00752 3460 Target 3941 DB00191

PDE5A HUMAN Vardenafil AOFB HUMAN Tranylcyprom AOFA HUMAN Phentermine ine..

Approved Approved Approved cGMP-specific Amine oxidase Amine oxidase 3’,5’-cyclic [flavin-containing] [flavin-containing] phosphodiesterase B A

3445 Target 276 DB00907 3453 Target 3939 DB00191 3461 Target 3941 DB00780

SC6A1 HUMAN Cocaine AOFB HUMAN Phentermine AOFA HUMAN Phenelzine

Approved Approved Approved Sodium- and Amine oxidase Amine oxidase chloride- [flavin-containing] [flavin-containing] dependent GABA B A transporter 1

3446 Target 276 DB00906 3454 Target 3939 DB00780 3462 Target 3941 DB01247

SC6A1 HUMAN Tiagabine AOFB HUMAN Phenelzine AOFA HUMAN Isocarboxazi d..

Approved Approved Approved Sodium- and Amine oxidase Amine oxidase chloride- [flavin-containing] [flavin-containing] dependent GABA B A transporter 1

3447 Target 696 DB00907 3455 Target 3939 DB01037 3463 Target 3941 DB01171

OPRK HUMAN Cocaine AOFB HUMAN Selegiline AOFA HUMAN Moclobemide

Approved Approved Approved Kappa-type opioid Amine oxidase Amine oxidase receptor [flavin-containing] [flavin-containing] B A

3448 Target 847 DB01444 3456 Target 3939 DB04677 3464 Target 4203 DB00613

OPRM HUMAN Dimethylthia AOFB HUMAN N-METHYL-N-[ HNMT HUMAN Amodiaquine mbuten.. (1R)-1..

Approved Mu-type opioid re- Amine oxidase Histamine N- ceptor [flavin-containing] methyltransferase B Drug-target pairs: R3 26

3465 Target 4203 DB04655 3473 Target 238 DB04689 3481 Target 29 DB01394

HNMT HUMAN METOPRINE, M PPARG HUMAN 2-(5-[3-(6-B TBB1 HUMAN Colchicine ETHODI.. ENZOYL..

Approved Histamine N- Peroxisome Tubulin beta-1 methyltransferase proliferator- chain activated receptor gamma

3466 Target 2452 DB00150 3474 Target 238 DB01076 3482 Target 29 DB01229

SYW BACST L-Tryptophan PPARG HUMAN Atorvastatin TBB1 HUMAN Paclitaxel

Approved Approved Approved Tryptophanyl- Peroxisome Tubulin beta-1 tRNA synthetase proliferator- chain activated receptor gamma

3467 Target 4063 DB00150 3475 Target 4108 DB00643 3483 Target 29 DB01248

SYWM HUMAN L-Tryptophan TBB TRITR Mebendazole TBB1 HUMAN Docetaxel

Approved Approved Approved Tryptophanyl- Tubulin beta Tubulin beta-1 tRNA synthetase, chain chain mitochondrial

3468 Target 267 DB01076 3476 Target 161 DB00361 3484 Target 273 DB01248

PAI1 HUMAN Atorvastatin TBB2 HUMAN Vinorelbine BCL2 HUMAN Docetaxel

Approved Approved Approved Plasminogen acti- Tubulin beta-2 Apoptosis regula- vator inhibitor 1 chain tor Bcl-2 precursor

3469 Target 267 DB00197 3477 Target 161 DB00570 3485 Target 273 DB01229

PAI1 HUMAN Troglitazone TBB2 HUMAN Vinblastine BCL2 HUMAN Paclitaxel

Approved Approved Plasminogen acti- Tubulin beta-2 Apoptosis regula- vator inhibitor 1 chain tor Bcl-2 precursor

3470 Target 238 DB00197 3478 Target 161 DB00541 3486 Target 273 DB01367

PPARG HUMAN Troglitazone TBB2 HUMAN Vincristine BCL2 HUMAN Rasagiline

Approved Approved Peroxisome Tubulin beta-2 Apoptosis regula- proliferator- chain tor Bcl-2 activated receptor gamma

3471 Target 238 DB01132 3479 Target 161 DB01394 3487 Target 273 DB01065

PPARG HUMAN Pioglitazone TBB2 HUMAN Colchicine BCL2 HUMAN Melatonin

Approved Approved Approved Peroxisome Tubulin beta-2 Apoptosis regula- proliferator- chain tor Bcl-2 activated receptor gamma

3472 Target 238 DB00412 3480 Target 29 DB00309 3488 Target 494 DB01017

PPARG HUMAN Rosiglitazon TBB1 HUMAN Vindesine CASP1 HUMAN Minocycline e..

Approved Approved Approved Peroxisome Tubulin beta-1 Caspase-1 precur- proliferator- chain sor activated receptor gamma Drug-target pairs: R3 27

3489 Target 2828 DB03771 3497 Target 696 DB00327 3505 Target 847 DB00647

SQHC ALIAC Allyl-(4-[3- OPRK HUMAN Hydromorphon OPRM HUMAN Propoxyphene (4-Bro.. e..

Approved Approved Squalene–hopene Kappa-type opioid Mu-type opioid re- cyclase receptor ceptor

3490 Target 696 DB00652 3498 Target 696 DB00295 3506 Target 847 DB01227

OPRK HUMAN Pentazocine OPRK HUMAN Morphine OPRM HUMAN Levomethadyl Aceta..

Approved Approved Approved Kappa-type opioid Kappa-type opioid Mu-type opioid re- receptor receptor ceptor

3491 Target 696 DB00611 3499 Target 696 DB00318 3507 Target 847 DB01433

OPRK HUMAN Butorphanol OPRK HUMAN Codeine OPRM HUMAN Methadyl Ace tate..

Approved Approved Approved Kappa-type opioid Kappa-type opioid Mu-type opioid re- receptor receptor ceptor

3492 Target 696 DB00844 3500 Target 696 DB01497 3508 Target 847 DB00333

OPRK HUMAN Nalbuphine OPRK HUMAN Etorphine OPRM HUMAN Methadone

Approved Approved Kappa-type opioid Kappa-type opioid Mu-type opioid re- receptor receptor ceptor

3493 Target 696 DB00921 3501 Target 696 DB01209 3509 Target 847 DB01081

OPRK HUMAN Buprenorphin OPRK HUMAN Dezocine OPRM HUMAN Diphenoxylat e.. e..

Approved Approved Approved Kappa-type opioid Kappa-type opioid Mu-type opioid re- receptor receptor ceptor

3494 Target 696 DB00704 3502 Target 696 DB00193 3510 Target 847 DB06274

OPRK HUMAN Naltrexone OPRK HUMAN Tramadol OPRM HUMAN Alvimopan

Approved Approved Approved Kappa-type opioid Kappa-type opioid Mu-type opioid re- receptor receptor ceptor

3495 Target 696 DB00497 3503 Target 696 DB00647 3511 Target 847 DB00193

OPRK HUMAN Oxycodone OPRK HUMAN Propoxyphene OPRM HUMAN Tramadol

Approved Approved Approved Kappa-type opioid Kappa-type opioid Mu-type opioid re- receptor receptor ceptor

3496 Target 696 DB00956 3504 Target 696 DB00454 3512 Target 847 DB01209

OPRK HUMAN Hydrocodone OPRK HUMAN Meperidine OPRM HUMAN Dezocine

Approved Approved Approved Kappa-type opioid Kappa-type opioid Mu-type opioid re- receptor receptor ceptor Drug-target pairs: R3 28

3513 Target 847 DB00854 3521 Target 847 DB00327 3529 Target 847 DB00836

OPRM HUMAN Levorphanol OPRM HUMAN Hydromorphon OPRM HUMAN Loperamide e..

Approved Approved Approved Mu-type opioid re- Mu-type opioid re- Mu-type opioid receptor ceptor ceptor

3514 Target 847 DB00611 3522 Target 847 DB01452 3530 Target 847 DB00913

OPRM HUMAN Butorphanol OPRM HUMAN Heroin OPRM HUMAN Anileridine

Approved Approved Mu-type opioid re- Mu-type opioid re- Mu-type opioid receptor ceptor ceptor

3515 Target 847 DB00844 3523 Target 847 DB00318 3531 Target 4137 DB01497

OPRM HUMAN Nalbuphine OPRM HUMAN Codeine OPRX HUMAN Etorphine

Approved Approved Mu-type opioid re- Mu-type opioid re- Nociceptin recep- ceptor ceptor tor

3516 Target 847 DB00921 3524 Target 847 DB00295 3532 Target 467 DB01497

OPRM HUMAN Buprenorphin OPRM HUMAN Morphine OPRD HUMAN Etorphine e..

Approved Approved Mu-type opioid re- Mu-type opioid re- Delta-type opioid ceptor ceptor receptor

3517 Target 847 DB00704 3525 Target 847 DB01497 3533 Target 467 DB00318

OPRM HUMAN Naltrexone OPRM HUMAN Etorphine OPRD HUMAN Codeine

Approved Approved Mu-type opioid re- Mu-type opioid re- Delta-type opioid ceptor ceptor receptor

3518 Target 847 DB01192 3526 Target 847 DB01183 3534 Target 467 DB00295

OPRM HUMAN Oxymorphone OPRM HUMAN Naloxone OPRD HUMAN Morphine

Approved Approved Approved Mu-type opioid re- Mu-type opioid re- Delta-type opioid ceptor ceptor receptor

3519 Target 847 DB00497 3527 Target 847 DB00504 3535 Target 467 DB00327

OPRM HUMAN Oxycodone OPRM HUMAN Levallorphan OPRD HUMAN Hydromorphon e..

Approved Approved Approved Mu-type opioid re- Mu-type opioid re- Delta-type opioid ceptor ceptor receptor

3520 Target 847 DB00956 3528 Target 847 DB00652 3536 Target 467 DB00956

OPRM HUMAN Hydrocodone OPRM HUMAN Pentazocine OPRD HUMAN Hydrocodone

Approved Approved Approved Mu-type opioid re- Mu-type opioid re- Delta-type opioid ceptor ceptor receptor Drug-target pairs: R3 29

3537 Target 467 DB00497 3545 Target 467 DB01100 3553 Target 781 DB00222

OPRD HUMAN Oxycodone OPRD HUMAN Pimozide IRK11 HUMAN Glimepiride

Approved Approved Approved Delta-type opioid Delta-type opioid ATP-sensitive receptor receptor inward rectifier potassium channel 11

3538 Target 467 DB00704 3546 Target 467 DB01571 3554 Target 781 DB01252

OPRD HUMAN Naltrexone OPRD HUMAN 3-Methylfent IRK11 HUMAN Mitiglinide anyl..

Approved Approved Delta-type opioid Delta-type opioid ATP-sensitive receptor receptor inward rectifier potassium channel 11

3539 Target 467 DB01548 3547 Target 467 DB00813 3555 Target 781 DB00308

OPRD HUMAN Diprenorphin OPRD HUMAN Fentanyl IRK11 HUMAN Ibutilide e..

Approved Approved Delta-type opioid Delta-type opioid ATP-sensitive receptor receptor inward rectifier potassium channel 11

3540 Target 467 DB00844 3548 Target 1968 DB00204 3556 Target 781 DB00922

OPRD HUMAN Nalbuphine IRK12 HUMAN Dofetilide IRK11 HUMAN Levosimendan

Approved Approved Approved Delta-type opioid ATP-sensitive ATP-sensitive receptor inward rectifier inward rectifier potassium channel potassium channel 12 11

3541 Target 467 DB01183 3549 Target 781 DB00912 3557 Target 4209 DB00922

OPRD HUMAN Naloxone IRK11 HUMAN Repaglinide IRK8 HUMAN Levosimendan

Approved Approved Approved Delta-type opioid ATP-sensitive ATP-sensitive receptor inward rectifier inward rectifier potassium channel potassium channel 11 8

3542 Target 467 DB00611 3550 Target 781 DB01016 3558 Target 502 DB00805

OPRD HUMAN Butorphanol IRK11 HUMAN Glibenclamid 5HT2A HUMAN Minaprine e..

Approved Approved Approved Delta-type opioid ATP-sensitive 5- receptor inward rectifier hydroxytryptamine potassium channel 2A receptor 11

3543 Target 467 DB00836 3551 Target 781 DB00661 3559 Target 502 DB00176

OPRD HUMAN Loperamide IRK11 HUMAN Verapamil 5HT2A HUMAN Fluvoxamine

Approved Approved Approved Delta-type opioid ATP-sensitive 5- receptor inward rectifier hydroxytryptamine potassium channel 2A receptor 11

3544 Target 467 DB00647 3552 Target 781 DB00731 3560 Target 502 DB01239

OPRD HUMAN Propoxyphene IRK11 HUMAN Nateglinide 5HT2A HUMAN Chlorprothix ene..

Approved Approved Approved Delta-type opioid ATP-sensitive 5- receptor inward rectifier hydroxytryptamine potassium channel 2A receptor 11 Drug-target pairs: R3 30

3561 Target 502 DB00924 3569 Target 502 DB00752 3577 Target 502 DB06144

5HT2A HUMAN Cyclobenzapr 5HT2A HUMAN Tranylcyprom 5HT2A HUMAN Sertindole ine.. ine..

Approved Approved Approved 5- 5- 5- hydroxytryptamine hydroxytryptamine hydroxytryptamine 2A receptor 2A receptor 2A receptor

3562 Target 502 DB00434 3570 Target 502 DB00370 3578 Target 502 DB01242

5HT2A HUMAN Cyproheptadi 5HT2A HUMAN Mirtazapine 5HT2A HUMAN Clomipramine ne..

Approved Approved Approved 5- 5- 5- hydroxytryptamine hydroxytryptamine hydroxytryptamine 2A receptor 2A receptor 2A receptor

3563 Target 502 DB01267 3571 Target 502 DB00320 3579 Target 502 DB00777

5HT2A HUMAN Paliperidone 5HT2A HUMAN Dihydroergot 5HT2A HUMAN Propiomazine amine..

Approved Approved Approved 5- 5- 5- hydroxytryptamine hydroxytryptamine hydroxytryptamine 2A receptor 2A receptor 2A receptor

3564 Target 502 DB00734 3572 Target 502 DB00696 3580 Target 502 DB01238

5HT2A HUMAN Risperidone 5HT2A HUMAN Ergotamine 5HT2A HUMAN Aripiprazole

Approved Approved Approved 5- 5- 5- hydroxytryptamine hydroxytryptamine hydroxytryptamine 2A receptor 2A receptor 2A receptor

3565 Target 502 DB00843 3573 Target 502 DB00247 3581 Target 502 DB01224

5HT2A HUMAN Donepezil 5HT2A HUMAN Methysergide 5HT2A HUMAN Quetiapine

Approved Approved Approved 5- 5- 5- hydroxytryptamine hydroxytryptamine hydroxytryptamine 2A receptor 2A receptor 2A receptor

3566 Target 502 DB00715 3574 Target 502 DB00751 3582 Target 502 DB00604

5HT2A HUMAN Paroxetine 5HT2A HUMAN Epinastine 5HT2A HUMAN Cisapride

Approved Approved Approved 5- 5- 5- hydroxytryptamine hydroxytryptamine hydroxytryptamine 2A receptor 2A receptor 2A receptor

3567 Target 502 DB00285 3575 Target 502 DB06148 3583 Target 502 DB04599

5HT2A HUMAN Venlafaxine 5HT2A HUMAN Mianserin 5HT2A HUMAN Aniracetam

Approved Approved 5- 5- 5- hydroxytryptamine hydroxytryptamine hydroxytryptamine 2A receptor 2A receptor 2A receptor

3568 Target 502 DB01442 3576 Target 502 DB00246 3584 Target 590 DB01224

5HT2A HUMAN MMDA 5HT2A HUMAN Ziprasidone 5HT2C HUMAN Quetiapine

Approved Approved 5- 5- 5- hydroxytryptamine hydroxytryptamine hydroxytryptamine 2A receptor 2A receptor 2C receptor Drug-target pairs: R3 31

3585 Target 590 DB00370 3593 Target 590 DB01191 3601 Target 1010 DB01026

5HT2C HUMAN Mirtazapine 5HT2C HUMAN Dexfenfluram CP51A HUMAN Ketoconazole ine..

Approved Approved Approved 5- 5- Cytochrome P450 hydroxytryptamine hydroxytryptamine 51A1 2C receptor 2C receptor

3586 Target 590 DB06148 3594 Target 590 DB01239 3602 Target 1010 DB01167

5HT2C HUMAN Mianserin 5HT2C HUMAN Chlorprothix CP51A HUMAN Itraconazole ene..

Approved Approved Approved 5- 5- Cytochrome P450 hydroxytryptamine hydroxytryptamine 51A1 2C receptor 2C receptor

3587 Target 590 DB00247 3595 Target 590 DB00193 3603 Target 1010 DB00251

5HT2C HUMAN Methysergide 5HT2C HUMAN Tramadol CP51A HUMAN Terconazole

Approved Approved Approved 5- 5- Cytochrome P450 hydroxytryptamine hydroxytryptamine 51A1 2C receptor 2C receptor

3588 Target 590 DB00246 3596 Target 3961 DB01016 3604 Target 233 DB00204

5HT2C HUMAN Ziprasidone IRK5 HUMAN Glibenclamid KCNK2 HUMAN Dofetilide e..

Approved Approved Approved 5- G protein- Potassium channel hydroxytryptamine activated inward subfamily K mem- 2C receptor rectifier potas- ber 2 sium channel 4

3589 Target 590 DB00777 3597 Target 4150 DB01051 3605 Target 1539 DB01140

5HT2C HUMAN Propiomazine GYRB STAAU Novobiocin S15A1 HUMAN Cefadroxil

Approved Approved Approved 5- DNA gyrase sub- Oligopeptide hydroxytryptamine unit B transporter, small 2C receptor intestine isoform

3590 Target 590 DB06144 3598 Target 1281 DB01064 3606 Target 1974 DB01140

5HT2C HUMAN Sertindole P85A HUMAN Isoprotereno S15A2 HUMAN Cefadroxil l..

Approved Approved Approved 5- Phosphatidylinositol Oligopeptide hydroxytryptamine 3-kinase regu- transporter, 2C receptor latory subunit kidney isoform alpha

3591 Target 590 DB00805 3599 Target 1010 DB00196 3607 Target 202 DB00848

5HT2C HUMAN Minaprine CP51A HUMAN Fluconazole Q9N587 CAEEL Levamisole

Approved Approved Approved 5- Cytochrome P450 Uncoordinated hydroxytryptamine 51A1 protein 63 2C receptor

3592 Target 590 DB00574 3600 Target 1010 DB01110 3608 Target 3923 DB00989

5HT2C HUMAN Fenfluramine CP51A HUMAN Miconazole CHLE HUMAN Rivastigmine

Approved Approved 5- Cytochrome P450 Cholinesterase hydroxytryptamine 51A1 2C receptor Drug-target pairs: R3 32

3609 Target 1680 DB00292 3617 Target 633 DB00923 3625 Target 633 DB01053

GTR1 HUMAN Etomidate Q8XJ01 CLOPE Ceforanide Q8XJ01 CLOPE Penicillin G

Approved Approved Approved Solute carrier Penicillin-binding Penicillin-binding family 2, facil- proteins 1A/1B proteins 1A/1B itated glucose transporter member 1

3610 Target 1075 DB00848 3618 Target 633 DB00567 3626 Target 633 DB00578

PPBN HUMAN Levamisole Q8XJ01 CLOPE Cephalexin Q8XJ01 CLOPE Carbenicilli n..

Approved Approved Approved Alkaline Penicillin-binding Penicillin-binding phosphatase, proteins 1A/1B proteins 1A/1B placental-like precursor

3611 Target 633 DB01147 3619 Target 633 DB00833 3627 Target 633 DB00948

Q8XJ01 CLOPE Cloxacillin Q8XJ01 CLOPE Cefaclor Q8XJ01 CLOPE Mezlocillin

Approved Approved Approved Penicillin-binding Penicillin-binding Penicillin-binding proteins 1A/1B proteins 1A/1B proteins 1A/1B

3612 Target 633 DB00301 3620 Target 633 DB00689 3628 Target 633 DB01061

Q8XJ01 CLOPE Flucloxacill Q8XJ01 CLOPE Cephaloglyci Q8XJ01 CLOPE Azlocillin in.. n..

Approved Approved Approved Penicillin-binding Penicillin-binding Penicillin-binding proteins 1A/1B proteins 1A/1B proteins 1A/1B

3613 Target 633 DB00485 3621 Target 633 DB00447 3629 Target 633 DB00319

Q8XJ01 CLOPE Dicloxacilli Q8XJ01 CLOPE Loracarbef Q8XJ01 CLOPE Piperacillin n..

Approved Approved Approved Penicillin-binding Penicillin-binding Penicillin-binding proteins 1A/1B proteins 1A/1B proteins 1A/1B

3614 Target 633 DB00713 3622 Target 633 DB01602 3630 Target 633 DB00739

Q8XJ01 CLOPE Oxacillin Q8XJ01 CLOPE Bacampicilli Q8XJ01 CLOPE Hetacillin n..

Approved Approved Approved Penicillin-binding Penicillin-binding Penicillin-binding proteins 1A/1B proteins 1A/1B proteins 1A/1B

3615 Target 633 DB01328 3623 Target 633 DB01604 3631 Target 633 DB00607

Q8XJ01 CLOPE Cefonicid Q8XJ01 CLOPE Pivampicilli Q8XJ01 CLOPE Nafcillin n..

Approved Approved Approved Penicillin-binding Penicillin-binding Penicillin-binding proteins 1A/1B proteins 1A/1B proteins 1A/1B

3616 Target 633 DB01326 3624 Target 633 DB00415 3632 Target 633 DB00430

Q8XJ01 CLOPE Cefamandole Q8XJ01 CLOPE Ampicillin Q8XJ01 CLOPE Cefpiramide

Approved Approved Approved Penicillin-binding Penicillin-binding Penicillin-binding proteins 1A/1B proteins 1A/1B proteins 1A/1B Drug-target pairs: R3 33

3633 Target 633 DB01329 3641 Target 1337 DB01104 3649 Target 102 DB00762

Q8XJ01 CLOPE Cefoperazone CP3A3 HUMAN Sertraline TOP1M HUMAN Irinotecan

Approved Approved Approved Penicillin-binding Cytochrome P450 DNA topoi- proteins 1A/1B 3A3 somerase I, mitochondrial precursor

3634 Target 633 DB01140 3642 Target 1337 DB00758 3650 Target 102 DB01030

Q8XJ01 CLOPE Cefadroxil CP3A3 HUMAN Clopidogrel TOP1M HUMAN Topotecan

Approved Approved Approved Penicillin-binding Cytochrome P450 DNA topoi- proteins 1A/1B 3A3 somerase I, mitochondrial precursor

3635 Target 633 DB01060 3643 Target 3086 DB02505 3651 Target 1498 DB01076

Q8XJ01 CLOPE Amoxicillin PLM2 PLAFA N-(R-Carboxy CD40L HUMAN Atorvastatin -Ethyl..

Approved Approved Penicillin-binding Plasmepsin-2 pre- CD40 ligand proteins 1A/1B cursor

3636 Target 633 DB01150 3644 Target 1939 DB04588 3652 Target 322 DB02638

Q8XJ01 CLOPE Cefprozil HS90A HUMAN N-[4-(AMINOS V2R HUMAN Terlipressin ULFONY..

Approved Approved Penicillin-binding Heat shock pro- Vasopressin V2 re- proteins 1A/1B tein HSP 90-alpha ceptor

3637 Target 633 DB01603 3645 Target 1939 DB00615 3653 Target 322 DB00872

Q8XJ01 CLOPE Meticillin HS90A HUMAN Rifabutin V2R HUMAN Conivaptan

Approved Approved Approved Penicillin-binding Heat shock pro- Vasopressin V2 re- proteins 1A/1B tein HSP 90-alpha ceptor

3638 Target 1337 DB00637 3646 Target 1353 DB04690 3654 Target 185 DB00872

CP3A3 HUMAN Astemizole TOP1 HUMAN Camptothecin V1AR HUMAN Conivaptan

Approved Approved Cytochrome P450 DNA topoiso- Vasopressin V1a 3A3 merase 1 receptor

3639 Target 1337 DB01076 3647 Target 1353 DB01030 3655 Target 185 DB02638

CP3A3 HUMAN Atorvastatin TOP1 HUMAN Topotecan V1AR HUMAN Terlipressin

Approved Approved Approved Cytochrome P450 DNA topoiso- Vasopressin V1a 3A3 merase 1 receptor

3640 Target 1337 DB01200 3648 Target 1353 DB00762 3656 Target 940 DB01282

CP3A3 HUMAN Bromocriptin TOP1 HUMAN Irinotecan OXYR HUMAN Carbetocin e..

Approved Approved Approved Cytochrome P450 DNA topoiso- Oxytocin receptor 3A3 merase 1 Drug-target pairs: R3 34

3657 Target 850 DB02638 3665 Target 101 DB00661 3673 Target 70 DB00876

V1BR HUMAN Terlipressin KCNH2 HUMAN Verapamil AGTR1 HUMAN Eprosartan

Approved Approved Approved Vasopressin V1b Potassium Type-1 an- receptor voltage-gated giotensin II channel subfamily receptor H member 2

3658 Target 772 DB00308 3666 Target 101 DB00489 3674 Target 70 DB00966

KCNH7 HUMAN Ibutilide KCNH2 HUMAN Sotalol AGTR1 HUMAN Telmisartan

Approved Approved Approved Potassium Potassium Type-1 an- voltage-gated voltage-gated giotensin II channel subfamily channel subfamily receptor H member 7 H member 2

3659 Target 514 DB00308 3667 Target 101 DB00204 3675 Target 70 DB00796

KCNH6 HUMAN Ibutilide KCNH2 HUMAN Dofetilide AGTR1 HUMAN Candesartan

Approved Approved Approved Potassium Potassium Type-1 an- voltage-gated voltage-gated giotensin II channel subfamily channel subfamily receptor H member 6 H member 2

3660 Target 101 DB00308 3668 Target 101 DB01136 3676 Target 70 DB00275

KCNH2 HUMAN Ibutilide KCNH2 HUMAN Carvedilol AGTR1 HUMAN Olmesartan

Approved Approved Approved Potassium Potassium Type-1 an- voltage-gated voltage-gated giotensin II channel subfamily channel subfamily receptor H member 2 H member 2

3661 Target 101 DB00342 3669 Target 101 DB00637 3677 Target 70 DB00678

KCNH2 HUMAN Terfenadine KCNH2 HUMAN Astemizole AGTR1 HUMAN Losartan

Approved Approved Approved Potassium Potassium Type-1 an- voltage-gated voltage-gated giotensin II channel subfamily channel subfamily receptor H member 2 H member 2

3662 Target 101 DB01218 3670 Target 101 DB00276 3678 Target 70 DB00177

KCNH2 HUMAN Halofantrine KCNH2 HUMAN Amsacrine AGTR1 HUMAN Valsartan

Approved Approved Approved Potassium Potassium Type-1 an- voltage-gated voltage-gated giotensin II channel subfamily channel subfamily receptor H member 2 H member 2

3663 Target 101 DB01182 3671 Target 101 DB00604 3679 Target 70 DB01029

KCNH2 HUMAN Propafenone KCNH2 HUMAN Cisapride AGTR1 HUMAN Irbesartan

Approved Approved Approved Potassium Potassium Type-1 an- voltage-gated voltage-gated giotensin II channel subfamily channel subfamily receptor H member 2 H member 2

3664 Target 101 DB01118 3672 Target 70 DB01347 3680 Target 70 DB01349

KCNH2 HUMAN Amiodarone AGTR1 HUMAN Saprisartan AGTR1 HUMAN Tasosartan

Approved Approved Approved Potassium Type-1 an- Type-1 an- voltage-gated giotensin II giotensin II channel subfamily receptor receptor H member 2 Drug-target pairs: R3 35

3681 Target 70 DB01342 3689 Target 1827 DB01136 3697 Target 284 DB01045

AGTR1 HUMAN Forasartan CXA1 HUMAN Carvedilol RPOB ECOLI Rifampin

Approved Approved Approved Type-1 an- Gap junction DNA-directed giotensin II alpha-1 protein RNA polymerase receptor beta chain

3682 Target 124 DB01142 3690 Target 249 DB01263 3698 Target 208 DB01045

HRH2 HUMAN Doxepin CP51 YEAST Posaconazole RPOC MYCTU Rifampin

Approved Approved Approved Histamine H2 re- Cytochrome P450 DNA-directed ceptor 51 RNA polymerase beta’ chain

3683 Target 124 DB00751 3691 Target 249 DB00251 3699 Target 208 DB01201

HRH2 HUMAN Epinastine CP51 YEAST Terconazole RPOC MYCTU Rifapentine

Approved Approved Approved Histamine H2 re- Cytochrome P450 DNA-directed ceptor 51 RNA polymerase beta’ chain

3684 Target 427 DB04894 3692 Target 249 DB01026 3700 Target 1760 DB00973

NK1R HUMAN Vapreotide CP51 YEAST Ketoconazole AMPN HUMAN Ezetimibe

Approved Approved Approved Substance-P Cytochrome P450 Aminopeptidase N receptor 51

3685 Target 427 DB01221 3693 Target 761 DB01167 3701 Target 1760 DB06196

NK1R HUMAN Ketamine CP51 CANGA Itraconazole AMPN HUMAN Icatibant

Approved Approved Approved Substance-P Cytochrome P450 Aminopeptidase N receptor 51

3686 Target 427 DB00673 3694 Target 3930 DB01076 3702 Target 5407 DB04692

NK1R HUMAN Aprepitant MCM7 HUMAN Atorvastatin R1AB CVHSA (E)-(S)-4-[( S)-2-(..

Approved Approved Substance-P DNA replication Replicase polypro- receptor licensing factor tein 1ab MCM7

3687 Target 1129 DB04835 3695 Target 5717 DB04608 3703 Target 230 DB01016

CCR5 HUMAN Maraviroc WEE1 HUMAN 9-HYDROXY-4- ABCC8 HUMAN Glibenclamid PHENYL.. e..

Approved Approved C-C chemokine re- Wee1-like protein ATP-binding cas- ceptor type 5 kinase sette transporter sub-family C member 8

3688 Target 754 DB00522 3696 Target 284 DB01220 3704 Target 132 DB01016

LIPP HUMAN Bentiromide RPOB ECOLI Rifaximin ABCA1 HUMAN Glibenclamid e..

Approved Approved Approved Pancreatic tria- DNA-directed ATP-binding cas- cylglycerol lipase RNA polymerase sette sub-family A precursor beta chain member 1 Drug-target pairs: R3 36

3705 Target 862 DB01016 3713 Target 847 DB00813 3721 Target 432 DB00246

MRP1 HUMAN Glibenclamid OPRM HUMAN Fentanyl DRD4 HUMAN Ziprasidone e..

Approved Approved Approved Multidrug Mu-type opioid re- D(4) dopamine re- resistance- ceptor ceptor associated protein 1

3706 Target 521 DB01016 3714 Target 847 DB01535 3722 Target 432 DB00777

ABCC9 HUMAN Glibenclamid OPRM HUMAN Carfentanil DRD4 HUMAN Propiomazine e..

Approved Approved ATP-binding cas- Mu-type opioid re- D(4) dopamine re- sette transporter ceptor ceptor sub-family C member 9

3707 Target 2184 DB01016 3715 Target 226 DB00644 3723 Target 1256 DB06144

CFTR HUMAN Glibenclamid GNRHR HUMAN Gonadorelin 5HT6R HUMAN Sertindole e..

Approved Approved Approved Cystic fibrosis Gonadotropin- 5- transmembrane releasing hormone hydroxytryptamine conductance receptor 6 receptor regulator

3708 Target 1709 DB01016 3716 Target 226 DB00666 3724 Target 1256 DB00904

MRP3 HUMAN Glibenclamid GNRHR HUMAN Nafarelin 5HT6R HUMAN Ondansetron e..

Approved Approved Approved Canalicular mul- Gonadotropin- 5- tispecific organic releasing hormone hydroxytryptamine anion transporter receptor 6 receptor 2

3709 Target 1385 DB00691 3717 Target 131 DB00206 3725 Target 1256 DB01488

ACE2 HUMAN Moexipril VMAT2 HUMAN Reserpine 5HT6R HUMAN Dimethyltryp tamine..

Approved Approved Angiotensin- Synaptic vesicular 5- converting amine transporter hydroxytryptamine enzyme 2 6 receptor precursor

3710 Target 696 DB00370 3718 Target 131 DB04844 3726 Target 1256 DB00889

OPRK HUMAN Mirtazapine VMAT2 HUMAN Tetrabenazin 5HT6R HUMAN Granisetron e..

Approved Approved Approved Kappa-type opioid Synaptic vesicular 5- receptor amine transporter hydroxytryptamine 6 receptor

3711 Target 696 DB01571 3719 Target 432 DB00714 3727 Target 94 DB00315

OPRK HUMAN 3-Methylfent DRD4 HUMAN Apomorphine 5HT4R HUMAN Zolmitriptan anyl..

Approved Approved Kappa-type opioid D(4) dopamine re- 5- receptor ceptor hydroxytryptamine 4 receptor

3712 Target 847 DB01571 3720 Target 432 DB00268 3728 Target 94 DB00953

OPRM HUMAN 3-Methylfent DRD4 HUMAN Ropinirole 5HT4R HUMAN Rizatriptan anyl..

Approved Approved Mu-type opioid re- D(4) dopamine re- 5- ceptor ceptor hydroxytryptamine 4 receptor Drug-target pairs: R3 37

3729 Target 94 DB01079 3737 Target 492 DB01237 3745 Target 492 DB00434

5HT4R HUMAN Tegaserod HRH1 HUMAN Bromodiphenh HRH1 HUMAN Cyproheptadi ydrami.. ne..

Approved Approved 5- Histamine H1 re- Histamine H1 re- hydroxytryptamine ceptor ceptor 4 receptor

3730 Target 94 DB00604 3738 Target 492 DB01173 3746 Target 492 DB01239

5HT4R HUMAN Cisapride HRH1 HUMAN Orphenadrine HRH1 HUMAN Chlorprothix ene..

Approved Approved Approved 5- Histamine H1 re- Histamine H1 re- hydroxytryptamine ceptor ceptor 4 receptor

3731 Target 68 DB06155 3739 Target 492 DB01146 3747 Target 492 DB01142

CNR1 HUMAN Rimonabant HRH1 HUMAN Diphenylpyra HRH1 HUMAN Doxepin line..

Approved Approved Approved Cannabinoid Histamine H1 re- Histamine H1 re- receptor 1 ceptor ceptor

3732 Target 68 DB00470 3740 Target 492 DB00283 3748 Target 492 DB00768

CNR1 HUMAN Marinol HRH1 HUMAN Clemastine HRH1 HUMAN Olopatadine

Approved Approved Approved Cannabinoid Histamine H1 re- Histamine H1 re- receptor 1 ceptor ceptor

3733 Target 68 DB00486 3741 Target 492 DB00342 3749 Target 492 DB00734

CNR1 HUMAN Nabilone HRH1 HUMAN Terfenadine HRH1 HUMAN Risperidone

Approved Approved Approved Cannabinoid Histamine H1 re- Histamine H1 re- receptor 1 ceptor ceptor

3734 Target 492 DB01106 3742 Target 492 DB00950 3750 Target 492 DB00767

HRH1 HUMAN Levocabastin HRH1 HUMAN Fexofenadine HRH1 HUMAN Benzquinamid e.. e..