February 4, 2014 u vol. 111 u no. 5 u 1659–2048

Cover image: Pictured are lyotropic chromonic liquid crystal (LCLC) droplets in oil. The LCLC molecules in the aligned (nematic) phase produce chiral configurations with two surface point defects. LCLC molecules in the columnar phase produce exotic faceted drop- lets with a central line defect. Joonwoo Jeong et al. report that these structures are driven by a delicate interplay between the highly anisotropic elasticity of the LCLCs and their boundary conditions on the droplet surface. The findings provide insight into the behavior of liquid crystals in aqueous environments. See the article by Jeong et al. on pages 1742–1747. Image courtesy of Joonwoo Jeong and Felice Macera (University of Pennsylvania, Philadelphia). From the Cover

1742 Elastic anisotropy in liquid crystals 1708 3D microscopy of historic artwork 1819 Proton permeation through membranes 1939 Dengue envelope determines immune response 1987 Oxytocin and social perception

Contents CORE CONCEPTS—A brief introduction to emerging topics in science 1661 Gnotobiotics Sarah C. P. Williams THIS WEEK IN PNAS QNAS 1659 In This Issue

1662 QnAs with Davis Masten and Peter Zandan Beth Azar LETTERS (ONLINE ONLY)

E531 Importance of a sound hydrologic foundation RETROSPECTIVE for assessing the future of the High Plains Aquifer in Kansas 1664 Pioneer of hematopoietic colony-stimulating James J. Butler, Jr., Geoffrey C. Bohling, Andrea E. factors: Leo Sachs (1924–2013) Brookfield, Gaisheng Liu, Donald O. Whittemore, Michael Sela and Yoram Groner and Blake B. Wilson E532 Reply to Butler et al.: A sound hydrologic foundation for interdisciplinary studies of the COMMENTARIES High Plains Aquifer David R. Steward, Paul J. Bruss, Xiaoying Yang, 1666 Inflammation promotes prostate differentiation Scott A. Staggenborg, Stephen M. Welch, Xian Liu and Andrew S. Goldstein and Michael D. Apley See companion article on page E592 E534 Do close relatives make bad neighbors? 1668 Prerequisites to proton transport in the bacterial Daniel Sol, Oriol Lapiedra, and Montserrat Vilà − + ClC-ec1 Cl /H exchanger E536 Including distantly related taxa can bias Mounir Tarek phylogenetic tests See companion article on page 1819 Marc W. Cadotte 1670 Human antibodies stop dengue virus by jamming its mechanics Shee-Mei Lok Free online through the PNAS open access option. See companion article on page 1939

PNAS u February 4, 2014 u vol. 111 u no. 5 u iii–viii Downloaded by guest on October 4, 2021 1672 Genetic predisposition of behavioral response CHEMISTRY Simon G. Gregory 1714 Comparison of the isomerization mechanisms of human See companion article on page 1987 melanopsin and invertebrate and vertebrate rhodopsins Silvia Rinaldi, Federico Melaccio, Samer Gozem, Francesca Fanelli, and Massimo Olivucci PNAS PLUS 1720 Guest–host interactions of a rigid organic molecule in porous silica frameworks Di Wu, Son-Jong Hwang, Stacey I. Zones, 1674 Significance Statements and Alexandra Navrotsky Brief statements written by the authors about the significance of their papers. COMPUTER SCIENCES 1921 Empirical prediction of genomic susceptibilities for multiple cancer classes INAUGURAL ARTICLE Minseung Kim and Sung-Hou Kim

1676 Lineage-specific expansions of TET/JBP genes and a new EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES class of DNA transposons shape fungal genomic and epigenetic landscapes 1726 Quantifying the distribution of nanodiamonds in Lakshminarayan M. Iyer, Dapeng Zhang, Robson F. de Souza, pre-Younger Dryas to recent age deposits along Bull Patricia J. Pukkila, Anjana Rao, and L. Aravind Creek, Oklahoma Panhandle, USA Leland C. Bement, Andrew S. Madden, Brian J. Carter, Alexander R. Simms, Andrew L. Swindle, Hanna M. Alexander, Scott Fine, and Mourad Benamara PHYSICAL SCIENCES 1732 Detection of solar wind-produced water in irradiated rims on silicate minerals APPLIED MATHEMATICS John P. Bradley, Hope A. Ishii, Jeffrey J. Gillis-Davis, James Ciston, Michael H. Nielsen, Hans A. Bechtel, E537 Hydrodynamics and collective behavior of the tethered and Michael C. Martin bacterium Thiovulum majus Alexander Petroff and Albert Libchaber ENGINEERING 1684 Rough parameter dependence in climate models and the role of Ruelle-Pollicott resonances 1927 Conformal piezoelectric energy harvesting and storage Mickaël David Chekroun, J. David Neelin, Dmitri from motions of the heart, lung, and diaphragm Kondrashov, James C. McWilliams, and Michael Ghil Canan Dagdeviren, Byung Duk Yang, Yewang Su, Phat L. Tran, Pauline Joe, Eric Anderson, Jing Xia, Vijay 1691 Compressed plane waves yield a compactly supported Doraiswamy, Behrooz Dehdashti, Xue Feng, Bingwei Lu, multiresolution basis for the Laplace operator Robert Poston, Zain Khalpey, Roozbeh Ghaffari, Yonggang Vidvuds Ozolin¸s, Rongjie Lai, Russel Caflisch, Huang, Marvin J. Slepian, and John A. Rogers and Stanley Osher ENVIRONMENTAL SCIENCES APPLIED PHYSICAL SCIENCES 1736 China’s international trade and air pollution in the E546 Role of clusters in nonclassical nucleation and growth United States of protein crystals Jintai Lin, Da Pan, Steven J. Davis, Qiang Zhang, Mike Sleutel and Alexander E. S. Van Driessche Kebin He, Can Wang, David G. Streets, Donald J. Wuebbles, and Dabo Guan 1697 Acoustic droplet vaporization is initiated by superharmonic focusing 1879 Gene-centric approach to integrating environmental Oleksandr Shpak, Martin Verweij, Hendrik J. Vos, genomics and biogeochemical models Nico de Jong, Detlef Lohse, and Michel Versluis Daniel C. Reed, Christopher K. Algar, Julie A. Huber, and Gregory J. Dick 1703 Highly sensitive electronic whiskers based on patterned carbon nanotube and silver nanoparticle composite films Kuniharu Takei, Zhibin Yu, Maxwell Zheng, Hiroki Ota, PHYSICS Toshitake Takahashi, and Ali Javey 1742 Chiral symmetry breaking and surface faceting in chromonic liquid crystal droplets with giant 1708 Femtosecond pump-probe microscopy generates virtual elastic anisotropy cross-sections in historic artwork Joonwoo Jeong, Zoey S. Davidson, Peter J. Collings, Tana Elizabeth Villafana, William P. Brown, John K. Tom C. Lubensky, and A. G. Yodh Delaney, Michael Palmer, Warren S. Warren, and Martin C. Fischer 1748 Self-replicating colloidal clusters Zorana Zeravcic and Michael P. Brenner 1807 Nonautonomous contact guidance signaling during collective cell migration 1754 Role of random electric fields in relaxors Camila Londono, M. Jimena Loureiro, Benjamin Slater, Daniel Phelan, Christopher Stock, Jose A. Rodriguez-Rivera, Petra B. Lücker, John Soleas, Suthamathy Sathananthan, Songxue Chi, Juscelino Leão, Xifa Long, Yujuan Xie, J. Stewart Aitchison, Alexandre J. Kabla, Alexei A. Bokov, Zuo-Guang Ye, Panchapakesan Ganesh, and Alison P. McGuigan and Peter M. Gehring

iv u www.pnas.org Downloaded by guest on October 4, 2021 1778 Inhibition of master transcription factors SOCIAL SCIENCES in pluripotent cells induces early stage differentiation ECONOMIC SCIENCES Debojyoti De, Myong-Ho Jeong, Young-Eun Leem, Dmitri I. Svergun, David E. Wemmer, Jong-Sun 1760 Small business activity does not Kang, Kyeong Kyu Kim, and Sung-Hou Kim measure entrepreneurship Magnus Henrekson and Tino Sanandaji 1784 Structure of sugar-bound LacY Hemant Kumar, Vladimir Kasho, Irina Smirnova, PSYCHOLOGICAL AND COGNITIVE SCIENCES Janet S. Finer-Moore, H. Ronald Kaback, and Robert M. Stroud 1981 Differences in the right inferior longitudinal fasciculus but no general disruption of white 1789 Variants of mouse DNA polymerase κ reveal matter tracts in children with autism a mechanism of efficient and accurate translesion spectrum disorder synthesis past a benzo[a]pyrene dG adduct Kami Koldewyn, Anastasia Yendiki, Sarah Weigelt, Yang Liu, Yeran Yang, Tie-Shan Tang, Hui Zhang, Hyowon Gweon, Joshua Julian, Hilary Richardson, Zhifeng Wang, Errol Friedberg, Wei Yang, Caitlin Malloy, Rebecca Saxe, Bruce Fischl, and Caixia Guo and Nancy Kanwisher 1795 CRL4-like Clr4 complex in Schizosaccharomyces pombe 1987 Common polymorphism in the oxytocin receptor depends on an exposed surface of Dos1 for gene (OXTR) is associated with human social heterochromatin silencing recognition skills Canan Kuscu, Mikel Zaratiegui, Hyun Soo Kim, David A. David H. Skuse, Adriana Lori, Joseph F. Cubells, Wah, Robert A. Martienssen, Thomas Schalch, Irene Lee, Karen N. Conneely, Kaija Puura, Terho and Leemor Joshua-Tor Lehtimäki, Elisabeth B. Binder, and Larry J. Young 1801 Probing large conformational rearrangements in See Commentary on page 1672 wild-type and mutant spectrin using structural mass spectrometry SUSTAINABILITY SCIENCE Sira Sriswasdi, Sandra L. Harper, Hsin-Yao Tang, 1736 China’s international trade and air pollution in the Patrick G. Gallagher, and David W. Speicher United States Jintai Lin, Da Pan, Steven J. Davis, Qiang Zhang, BIOPHYSICS AND COMPUTATIONAL BIOLOGY Kebin He, Can Wang, David G. Streets, Donald J. Wuebbles, and Dabo Guan E563 Toward rationally redesigning bacterial two-component signaling systems using coevolutionary information Ryan R. Cheng, Faruck Morcos, Herbert Levine, and José N. Onuchic BIOLOGICAL SCIENCES 1714 Comparison of the isomerization mechanisms of human melanopsin and invertebrate and vertebrate rhodopsins APPLIED BIOLOGICAL SCIENCES Silvia Rinaldi, Federico Melaccio, Samer Gozem, E554 Artificial riboswitches for gene expression and Francesca Fanelli, and Massimo Olivucci replication control of DNA and RNA viruses Patrick Ketzer, Johanna K. Kaufmann, Sarah Engelhardt, 1807 Nonautonomous contact guidance signaling during Sascha Bossow, Christof von Kalle, Jörg S. Hartig, Guy collective cell migration Ungerechts, and Dirk M. Nettelbeck Camila Londono, M. Jimena Loureiro, Benjamin Slater, Petra B. Lücker, John Soleas, Suthamathy Sathananthan, 1766 A general approach to site-specific antibody J. Stewart Aitchison, Alexandre J. Kabla, drug conjugates and Alison P. McGuigan Feng Tian, Yingchun Lu, Anthony Manibusan, Aaron Sellers, Hon Tran, Ying Sun, Trung Phuong, Richard 1813 Structure and mechanism of a eukaryotic Barnett, Brad Hehli, Frank Song, Michael J. DeGuzman, transmembrane ascorbate-dependent Semsi Ensari, Jason K. Pinkstaff, Lorraine M. Sullivan, oxidoreductase Sandra L. Biroc, Ho Cho, Peter G. Schultz, John Peilong Lu, Dan Ma, Chuangye Yan, Xinqi Gong, DiJoseph, Maureen Dougher, Dangshe Ma, Russell Mingjian Du, and Yigong Shi Dushin, Mauricio Leal, Lioudmila Tchistiakova, Eric 1819 Water access points and hydration pathways in Feyfant, Hans-Peter Gerber, and Puja Sapra CLC H+/Cl− transporters Wei Han, Ricky C. Cheng, Merritt C. Maduke, BIOCHEMISTRY and Emad Tajkhorshid See Commentary on page 1668 E546 Role of clusters in nonclassical nucleation and growth of protein crystals 1825 Functional map of arrestin-1 at single amino Mike Sleutel and Alexander E. S. Van Driessche acid resolution Martin K. Ostermaier, Christian Peterhans, Rolf Jaussi, 1772 Structure, domain organization, and different Xavier Deupi, and Jörg Standfuss conformational states of stem cell factor-induced intact KIT dimers 1831 Dynamics transitions at the outer vestibule of the Yarden Opatowsky, Irit Lax, Francisco Tomé, KcsA potassium channel during gating Franziska Bleichert, Vinzenz M. Unger, H. Raghuraman, Shahidul M. Islam, Soumi Mukherjee, and Joseph Schlessinger Benoit Roux, and Eduardo Perozo

PNAS u February 4, 2014 u vol. 111 u no. 5 u v Downloaded by guest on October 4, 2021 1837 Comprehensive structural model of the 1885 Complementary molecular information changes our mechanochemical cycle of a mitotic motor highlights perception of food web structure molecular adaptations in the kinesin family Helena K. Wirta, Paul D. N. Hebert, Riikka Kaartinen, Adeline Goulet, Jennifer Major, Yonggun Jun, Steven P. Sean W. Prosser, Gergely Várkonyi, and Tomas Roslin Gross, Steven S. Rosenfeld, and Carolyn A. Moores ENVIRONMENTAL SCIENCES CELL BIOLOGY 1726 Quantifying the distribution of nanodiamonds in E572 Induced multipotency in adult keratinocytes through pre-Younger Dryas to recent age deposits along Bull down-regulation of ΔNp63 or DGCR8 Creek, Oklahoma Panhandle, USA Deepavali Chakravarti, Xiaohua Su, Min Soon Cho, Leland C. Bement, Andrew S. Madden, Brian J. Carter, Ngoc Hoang Bao Bui, Cristian Coarfa, Avinashnarayan Alexander R. Simms, Andrew L. Swindle, Hanna M. Venkatanarayan, Ashley L. Benham, Ramón E. Alexander, Scott Fine, and Mourad Benamara Flores González, Jennifer Alana, Weimin Xiao, Marco L. Leung, Harina Vin, Io Long Chan, Arianexys Aquino, Nicole Müller, Hongran Wang, Austin J. EVOLUTION Cooney, Jan Parker-Thornburg, Kenneth Y. Tsai, 1676 Lineage-specific expansions of TET/JBP genes and a new Preethi H. Gunaratne, and Elsa R. Flores class of DNA transposons shape fungal genomic and epigenetic landscapes E582 Sel1L is indispensable for mammalian endoplasmic Lakshminarayan M. Iyer, Dapeng Zhang, Robson F. de Souza, reticulum-associated degradation, endoplasmic Patricia J. Pukkila, Anjana Rao, and L. Aravind reticulum homeostasis, and survival Shengyi Sun, Guojun Shi, Xuemei Han, Adam B. Francisco, Yewei Ji, Nuno Mendonça, Xiaojing Liu, Jason W. Locasale, GENETICS Kenneth W. Simpson, Gerald E. Duhamel, Sander Kersten, 1891 Molecular indexing enables quantitative targeted RNA John R. Yates III, Qiaoming Long, and Ling Qi sequencing and reveals poor efficiencies in standard 1843 TAp73 is required for spermatogenesis and the library preparations maintenance of male fertility Glenn K. Fu, Weihong Xu, Julie Wilhelmy, Michael N. Satoshi Inoue, Richard Tomasini, Alessandro Rufini, Mindrinos, Ronald W. Davis, Wenzhong Xiao, Andrew J. Elia, Massimiliano Agostini, Ivano Amelio, and Stephen P. A. Fodor Dave Cescon, David Dinsdale, Lily Zhou, Isaac S. Harris, 1897 Mutational landscape of yeast mutator strains Sophie Lac, Jennifer Silvester, Wanda Y. Li, Masato Alexandre Serero, Claire Jubin, Sophie Loeillet, Patricia Sasaki, Jillian Haight, Anne Brüstle, Andrew Wakeham, Legoix-Né, and Alain G. Nicolas Colin Mckerlie, Andrea Jurisicova, Gerry Melino, and Tak W. Mak 1903 Kinetochore assembly and heterochromatin formation occur autonomously in Schizosaccharomyces pombe 1849 Membrane adhesion dictates Golgi stacking and William R. A. Brown, Geraint Thomas, Nicholas C. O. Lee, cisternal morphology Martin Blythe, Gianni Liti, Jonas Warringer, Intaek Lee, Neeraj Tiwari, Myun Hwa Dunlop, Morven and Matthew W. Loose Graham, Xinran Liu, and James E. Rothman – 1855 Different modes of endothelial smooth muscle cell IMMUNOLOGY interaction elicit differential β-catenin phosphorylations and endothelial functions 1909 Novel antiviral host factor, TNK1, regulates IFN signaling Shun-Fu Chang, Li-Jing Chen, Pei-Ling Lee, Ding-Yu Lee, through serine phosphorylation of STAT1 Shu Chien, and Jeng-Jiann Chiu Ee Lyn Ooi, Stephanie T. Chan, Noell E. Cho, Courtney Wilkins, Jessica Woodward, Meng Li, Ushio Kikkawa, 1861 Processing of microRNA primary transcripts requires Timothy Tellinghuisen, Michael Gale, Jr., and Takeshi Saito heme in mammalian cells Sara H. Weitz, Ming Gong, Ian Barr, Shimon Weiss, 1915 Characterization of the IL-15 niche in primary and and Feng Guo secondary lymphoid organs in vivo Guangwei Cui, Takahiro Hara, Szandor Simmons, Keisuke Wagatsuma, Akifumi Abe, Hitoshi Miyachi, Satsuki Kitano, DEVELOPMENTAL BIOLOGY Masaru Ishii, Shizue Tani-ichi, and Koichi Ikuta 1867 In vitro analysis suggests that difference in cell movement during direct interaction can generate MEDICAL SCIENCES various pigment patterns in vivo Hiroaki Yamanaka and Shigeru Kondo E592 Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate 1873 Paternally induced transgenerational inheritance of cancer with a basal cell origin susceptibility to diabetes in mammals Oh-Joon Kwon, Li Zhang, Michael M. Ittmann, and Li Xin Yanchang Wei, Cai-Rong Yang, Yan-Ping Wei, Zhen-Ao See Commentary on page 1666 Zhao, Yi Hou, Heide Schatten, and Qing-Yuan Sun E601 Elevated expression of TANK-binding kinase 1 enhances tamoxifen resistance in breast cancer ECOLOGY Congwen Wei, Yuan Cao, Xiaoli Yang, Zirui Zheng, Kai 1879 Gene-centric approach to integrating environmental Guan, Qiang Wang, Yanhong Tai, Yanhong Zhang, Shengli genomics and biogeochemical models Ma, Ye Cao, Xiaoxing Ge, Changzhi Xu, Jia Li, Hui Yan, Daniel C. Reed, Christopher K. Algar, Julie A. Huber, Youguo Ling, Ting Song, Lin Zhu, Buchang Zhang, Quanbin and Gregory J. Dick Xu, Chengjin Hu, Xiu-wu Bian, Xiang He, and Hui Zhong

vi u www.pnas.org Downloaded by guest on October 4, 2021 1921 Empirical prediction of genomic susceptibilities for NEUROSCIENCE multiple cancer classes E618 Decision-related pupil dilation reflects upcoming choice Minseung Kim and Sung-Hou Kim and individual bias 1927 Conformal piezoelectric energy harvesting and storage Jan Willem de Gee, Tomas Knapen, and Tobias H. Donner from motions of the heart, lung, and diaphragm 1981 Differences in the right inferior longitudinal Canan Dagdeviren, Byung Duk Yang, Yewang Su, Phat L. fasciculus but no general disruption of white Tran, Pauline Joe, Eric Anderson, Jing Xia, Vijay matter tracts in children with autism Doraiswamy, Behrooz Dehdashti, Xue Feng, Bingwei Lu, spectrum disorder Robert Poston, Zain Khalpey, Roozbeh Ghaffari, Yonggang Kami Koldewyn, Anastasia Yendiki, Sarah Weigelt, Huang, Marvin J. Slepian, and John A. Rogers Hyowon Gweon, Joshua Julian, Hilary Richardson, 1933 Differential expression of estrogen receptor α, β1, and Caitlin Malloy, Rebecca Saxe, Bruce Fischl, β2 in lobular and ductal breast cancer and Nancy Kanwisher Bo Huang, Yoko Omoto, Hirotaka Iwase, Hiroko Yamashita, 1987 Common polymorphism in the oxytocin receptor Tatsuya Toyama, Raoul Charles Coombes, Aleksandra gene (OXTR) is associated with human social Filipovic, Margaret Warner, and Jan-Åke Gustafsson recognition skills David H. Skuse, Adriana Lori, Joseph F. Cubells, MICROBIOLOGY Irene Lee, Karen N. Conneely, Kaija Puura, Terho Lehtimäki, Elisabeth B. Binder, and Larry J. Young E537 Hydrodynamics and collective behavior of the tethered See Commentary on page 1672 bacterium Thiovulum majus Alexander Petroff and Albert Libchaber 1993 PIKE is essential for oligodendroglia development and CNS myelination E611 HSV-1 degrades, stabilizes, requires, or is stung by STING Chi Bun Chan, Xia Liu, Lixia Zhao, Guanglu Liu, depending on ICP0, the US3 protein kinase, and Chi Wai Lee, Yue Feng, and Keiqang Ye cell derivation Maria Kalamvoki and Bernard Roizman 1999 Spatiotemporal pattern of action potential firing in developing inner hair cells of the mouse cochlea 1939 Dengue virus envelope protein domain I/II hinge Gaston Sendin, Jérôme Bourien, François Rassendren, determines long-lived serotype-specific Jean-Luc Puel, and Régis Nouvian dengue immunity William B. Messer, Ruklanthi de Alwis, Boyd L. Yount, 2005 Essential role of poly(ADP-ribosyl)ation in cocaine action Scott R. Royal, Jeremy P. Huynh, Scott A. Smith, James E. Kimberly N. Scobie, Diane Damez-Werno, HaoSheng Sun, Crowe, Jr., Benjamin J. Doranz, Kristen M. Kahle, Jennifer M. NingYi Shao, Amy Gancarz, Clarisse H. Panganiban, Caroline Pfaff, Laura J. White, Carlos A. Sariol, Aravinda M. de Silva, Dias, JaWook Koo, Paola Caiafa, Lewis Kaufman, Rachael L. and Ralph S. Baric Neve, David M. Dietz, Li Shen, and Eric J. Nestler See Commentary on page 1670 1945 Self-poisoning of Mycobacterium tuberculosis by PHARMACOLOGY interrupting siderophore recycling 2011 Doxorubicin-induced carbonylation and degradation of Christopher M. Jones, Ryan M. Wells, Ashoka V. R. Madduri, cardiac myosin binding protein C promote cardiotoxicity Matthew B. Renfrow, Colin Ratledge, D. Branch Moody, Baikuntha Aryal, Jinsook Jeong, and V. Ashutosh Rao and Michael Niederweis 1951 ChREBP, a glucose-responsive transcriptional factor, PLANT BIOLOGY enhances glucose metabolism to support biosynthesis 2017 Inheritance of Trans Chromosomal Methylation patterns in human cytomegalovirus-infected cells from Arabidopsis F1 hybrids Yongjun Yu, Tobi G. Maguire, and James C. Alwine Ian K. Greaves, Michael Groszmann, Aihua Wang, W. James 1957 Direct cloning and refactoring of a silent lipopeptide Peacock, and Elizabeth S. Dennis biosynthetic gene cluster yields the antibiotic 2023 Tetrapyrrole biosynthetic enzyme protoporphyrinogen taromycin A IX oxidase 1 is required for plastid RNA editing Kazuya Yamanaka, Kirk A. Reynolds, Roland D. Kersten, Fan Zhang, Weijiang Tang, Boris Hedtke, Linlin Zhong, Katherine S. Ryan, David J. Gonzalez, Victor Nizet, Lin Liu, Lianwei Peng, Congming Lu, Bernhard Grimm, Pieter C. Dorrestein, and Bradley S. Moore and Rongcheng Lin 1963 PhoPQ regulates acidic glycerophospholipid content of 2029 CLE-CLAVATA1 peptide-receptor signaling module the Salmonella Typhimurium outer membrane regulates the expansion of plant root systems in Zachary D. Dalebroux, Susana Matamouros, Dale a nitrogen-dependent manner Whittington, Russell E. Bishop, and Samuel I. Miller Takao Araya, Mayu Miyamoto, Juliarni Wibowo, Akinori 1969 Programmed Allee effect in bacteria causes a tradeoff Suzuki, Soichi Kojima, Yumiko N. Tsuchiya, Shinichiro Sawa, between population spread and survival Hiroo Fukuda, Nicolaus von Wirén, and Hideki Takahashi Robert Smith, Cheemeng Tan, Jaydeep K. Srimani, Anand Pai, Katherine A. Riccione, Hao Song, PSYCHOLOGICAL AND COGNITIVE SCIENCES and Lingchong You 2035 Development of pattern vision following early and 1975 Quorum sensing controls hyphal initiation in extended blindness Candida albicans through Ubr1-mediated Amy Kalia, Luis Andres Lesmes, Michael Dorr, Tapan protein degradation Gandhi, Garga Chatterjee, Suma Ganesh, Peter J. Bex, Yang Lu, Chang Su, Ohimai Unoje, and Haoping Liu and Pawan Sinha

PNAS u February 4, 2014 u vol. 111 u no. 5 u vii Downloaded by guest on October 4, 2021 SYSTEMS BIOLOGY 2047 Confinement of caspase-12 proteolytic activity to E626 Parameterizing cell-to-cell regulatory heterogeneities autoprocessing via stochastic transcriptional profiles Sophie Roy, Jeffrey R. Sharom, Caroline Houde, Sameer S. Bajikar, Christiane Fuchs, Andreas Roller, Thomas P. Loisel, John P. Vaillancourt, Wei Shao, Fabian J. Theis, and Kevin A. Janes Maya Saleh, and Donald W. Nicholson 2040 Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian IMMUNOLOGY circadian clock 2047 MicroRNA-directed program of cytotoxic CD8+ Peter C. St. John, Tsuyoshi Hirota, Steve A. Kay, T-cell differentiation and Francis J. Doyle III Sara Trifari, Matthew E. Pipkin, Hozefa S. Bandukwala, Tarmo Äijö, Jed Bassein, CORRECTIONS Runqiang Chen, Gustavo J. Martinez, and Anjana Rao

LETTER (ONLINE ONLY) E530 Reply to Li and Wu: Arctic sea ice and winter snowfall MEDICAL SCIENCES, ENGINEERING Jiping Liu, Judith A. Curry, Huijun Wang, Radley M. 2047 Generation of functionally competent and durable Horton, and Mirong Song engineered blood vessels from human induced pluripotent stem cells BIOCHEMISTRY Rekha Samuel, Laurence Daheron, Shan Liao, Trupti 2046 Enhancing nuclear receptor-induced transcription Vardam, Walid S. Kamoun, Ana Batista, Christa requires nuclear motor and LSD1-dependent gene Buecker, Richard Schäfer, Xiaoxing Han, Patrick Au, networking in interchromatin granules David T. Scadden, Dan G. Duda, Dai Fukumura, Qidong Hu, Young-Soo Kwon, Esperanza Nunez, Maria and Rakesh K. Jain Dafne Cardamone, Kasey R. Hutt, Kenneth A. Ohgi, Ivan Garcia-Bassets, David W. Rose, Christopher K. Glass, Michael G. Rosenfeld, and Xiang-Dong Fu ix Subscription Form

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