veins have supplied the compensatory circulation necessary for Current Medical Literature the functioning of the heart muscle. Reciprocal Beating of Heart.—The clinical and electro- AMERICAN cardiographic aspects of four cases of reciprocal beating of the heart are recorded The Association library lends periodicals to Fellows of the Association by Blumgart and Gargill and the nature of and to individual subscribers to The Journal in continental United the abnormal mechanism is discussed. In one case the distur¬ States and Canada for a period of three days. Issues of periodicals are bance was sufficiently prolonged to permit extensive pharma¬ kept on file for a period of five years only. Requests for issues of earlier cologie study. This indicated that date cannot be filled. Requests should be accompanied by stamps to study reciprocal beating was cover postage (6 cents if one and 12 cents if two periodicals are requested). influenced mainly by vagai hypertonicity. Periodicals published by the American Medical Association are not avail¬ Circulatory Mechanism in Arterial able for but be order. as Hypertension.—A lending, may supplied on purchase Reprints a is rule are the property of authors and can be obtained for permanent posses¬ study presented by Weiss and Ellis of the circulatory mecha¬ sion only from them. nism in thirty patients with hypertension. Although the aver¬ Titles marked with an asterisk (*) are abstracted below. age resistance of the arteriolar system of the greater circulation was twice as American Heart St. Louis great in the patients as in the normal control Journal, subjects, the circulating blood the cardiac 5: 401-544 (April) 1930 volume, output per minute, the arm to face velocity of the blood and the of Differences in Potency of in Clinical Practice. flow, •Importance Digitalis mean the were J. Wyckofï, H. Gold and J. G. Travell, New York.—p. 401. velocity of circulation either normal or slightly •Complete Occlusion of Both Coronary Orillees: Two Cases. T. Leary below normal. Although the peripheral resistance was increased and J. T. Wearn, Boston.—p. 412. to twice normal, the estimated work of the left ventricle of •Reciprocal Beating of Heart: Electrocardiographic and Pharmacologie the heart in hypertension was only 41 per cent greater than Study. H. L. Blumgart and S. L. Gargill, Boston.—p. 424. in normal Mechanism of Transitions from Auriculoventricular Dissociation to S-A subjects. A satisfactory explanation of the dynamics Rhythm: Relation to Theory of Parasystole. II. L. Blumgart and of the circulation in the patients with hypertension studied is S. L. Gargill, Boston.—p. 437. that, because of the abnormally accentuated arteriolar resis¬ •Quantitative and Dynamics of Mechanism in Arterial Aspects Circulatory tance, a arterial and arteriolar is essential to Hypertension. S. Weiss and L. B. Ellis, Boston.—p. 448. high pressure Disappearance of Intraventricular Heart Block Occurring in Uremia reestablish the normal capillary blood flow and pressure in the Following Intravenous Injection of Hypertonie Dextrose Solution. vital organs. The measurements and observations do not bear N. Moore and H. S. J. Stewart, New York.—p. 469. out the hypothesis that loss of the elasticity of the great •Paroxysmal Tachycardia with Myocardial Lesions: Case. R. H. Major increased and H. R. Wahl, Kansas City, Kan.—p. 477. arteries, cardiac output, increased circulating blood •So-Called Interpolation of Extrasystoles During Idioventricular Rhythm. volume or hypoventilation and decreased blood content of the C. C. Wolferth, Philadelphia.—p. 482. lungs is responsible for the presence of hypertension. The Complete Heart Block Associated with Rapid Ventricular Rate: Two between cardiac arterial B. Bloom and S. Perlow, 486. relationship output, pressure, peripheral Cases. Chicago.—p. resistance •Standstill of Heart of Vagai Origin. A. M. Wedd, Clifton Springs, and capillary circulation determines the nature of N. Y., and D. C. Wilson, Charlottesville, Va.—p. 493. the therapeutic procedures applicable in hypertension. in •Electrocardiographic Changes Quiescent Rheumatic Disease in Chil¬ with dren and Young Adults. M. J. Shapiro, Minneapolis.—p. 504. Paroxysmal Tachycardia Myocardial Lesions.— Al a or Density of Surface Capillary Bed of Forearm in Health, in Arterial j and Wahl have had the opportunity of studying a Hypertension, and in Arteriosclerosis. S. Weiss and W. R. Frazier, patient suffering from paroxysmal tachycardia of auricular Boston.—p. 511. origin, who died during the attack and on whom a Localized Swearing: Sympathetic Reflex Phenomenon in Angina Pectoris. necropsy R. S. Palmer, Boston.—p. 519. was obtained. This patient showed at autopsy an acute and Localized Sweating Replacing Cardiac Pain. E. Holt, New York.— chronic myocarditis. The myocarditis was obviously infectious, p. 522. and the patient's infected tonsils, which were removed approxi¬ Permanent Bradycardia Following Diphtheria: Case. W. D. Reid, Boston.—p. 524. mately one year before the onset of this attack, may have been the portal of entry for the infection. It is interesting that of Differences in Importance Potency of Digitalis in this patient's attacks at first had a sudden onset and a sudden Clinical Practice.—An analysis of the factors involved in the termination and clinically belonged definitely in the group of application the bio-assay of digitalis by the cat method to described by Bouveret, who insisted on this criterion for diag¬ clinical practice is made by Wyckoff et al. Evidence is pre¬ nosis. In this last attack, however, the tachycardia did not sented showing that body weight is a factor in digitalis dosage cease suddenly but gradually, the patient's pulse coming down and that it is essential to take into account differences in the to normal over a period of four days. The duration of this potency of digitalis as determined by bio-assay. It is pointed attack was unusually long, the patient having had the condi¬ out that when small doses of digitalis are used, the value of tion two weeks before admission and being under observation both factors (body weight and differences in potency) may ten days in the hospital—twenty-four days in all. escape detection. An analysis is made of the experience of So-Called Interpolation of Extrasystoles During Idio- of the committee for the study digitalis in pneumonia at Belle¬ ventricular Rhythm.—An electrocardiogram obtained from a vue Hospital with a well known commercial preparation of patient with complete heart block and what might be regarded digitalis, the potency of which was later proved to have been as interpolated extrasystoles is presented by Wolferth. It is incorrectly labeled by the manufacturer. This analysis shows, concluded that, thus far, there has been no proof of the occur¬ in the first place, that a specimen of digitalis which was found rence of interpolated beats during idioventricular rhythm. to be about twice as active as for man anticipated proved to Standstill of Heart of Vagai Origin.—A case is described be also twice as active by the cat method of assay ; and sec¬ by Wedd and Wilson which exhibited permanent nodal rhythm, ondly, the dangers arising from the use of digitalis, especially with periods of standstill of the whole heart and of high grade in large doses, when the exact potency is not known. Evidence bradycardia. The disappearance of these unusual disturbances is presented showing the confusion that arises from the use of rhythm following exercise and atropine is proof of vagai term "standardized a of the digitalis" without statement of the origin. From a consideration of the mental and emotional exact potency, because of the different standards used by make-up of the patient and of the circumstances associated the various manufacturers. The relative merits of so-called with increased vagai tone, it seems certain that the and weaker of primary stronger preparations digitalis are discussed. factor was a psychic one. Complete Occlusion of Both Coronary Orifices.—Two Electrocardiographic Changes in Quiescent Rheumatic cases of essential closure of both coronary orifices are reported Disease in Children and Young Adults. Electrocardio¬

and Wearn. — by Leary The lesions indicated a slowly progres¬ graphic tracings were made by Shapiro in 119 children which had giving sive process probably taken months at least to reach a history of rheumatic disease who were able to attend' school the point of essentially complete closure. No evidences of regularly ; tracings were also made in fifty normal children fatty change, myocarditis or repair were found in the heart who were used as controls. Many of the tracings taken from The muscle. only adequate explanation of the ability of these the children in the so-called quiescent group showed changes patients to live and work rests on a belief that the thebesian similar to those found in acute rheumatic fever, but the changes

Downloaded From: http://jama.jamanetwork.com/ by a University of Arizona Health Sciences Library User on 05/29/2015 were found less frequently. tracings taken from chil¬ Better Protection in Vertical Fluoroscopy. J. Belot, Paris, France.— Repeated 859. dren in the showed variations similar to those p. quiescent group Improved Uterine Radium Applicator. H. Swanberg, Quincy, 111. found in the acute group. In the control group the tracings —p. 862. did not vary. The most common and most persistent finding Importance of Urography in Interpretation of Abdominal Symptoms. C. W. Moots and A. H. in this quiescent group was the lack of iso-electric period J. Magoun, Toledo, Ohio.—p. 866. Inflammation of Appendix. E. Hönck, Hamburg, Germany.—p. 872. between the R or S wave and the wave and the marked variability of the R-T or S-T interval from time to time. Cuticular Suture. Tomaiuoli makes a mattress suture, each loop on the surface— passing through a piece of rubber American Journal of Ophthalmology, Chicago tubing one-fourth inch long. It is said to be of special advan¬ 13: 379-472 (May) 1930 tage wherever the scar may show and in the flabby, pendulous New Eye and Hand Method of Training Squints. . E. Maddox, abdomen of multíparas, in which there is an infallible ten¬ Bournemouth, England.—p. 379. dency for the skin edges to overlap when sutured. The suture Trachoma Among Indians. W. H. Wilder, 387. Chicago.—p. in question makes overlapping impossible the use of the Traumatic Rupture of Choroid with Detachment of Retina: Spontaneous by Reattachment. A. J. Bedell, Albany, . Y.—p. 390. small pieces of rubber tubings, whose purpose is twofold : first, Tonometry and Various Instruments Employed in Practice. R. I. Lloyd, to prevent the silk from cutting through the skin, and second, New York.—p. 396. to maintain the skin edges everted, thereby assuring a perfect Melanosarcoma at W. Kansas 407. Limbus. J. McKee, City, Mo.—p. alinement of the cut surfaces. Anatomic-Surgical Approach to Optic Nerve. D. M. Velez, Mexico City. —p. 408. Eye Observations in Tuberculous Patients at State Sanatorium, Cresson, Archives of Dermatology & Syphilology, Chicago Pennsylvania. L. P. Glover, Altoona, Pa.—p. 411. 81: 721-908 1930 Concentric Contraction of Visual Fields. W. D. Rowland and A. W. (May) 413. *Cutaneous Manifestations of Heredity. C. M. Williams, New York.— Rowe, Boston.—p. 721. Cod Liver Oil in Treatment of Corneal C. M. Stiles, Phila¬ p. Opacities. Inorganic Salts of Blood in F. delphia.—p. 423. Psoriasis. J. Schamberg and H. Brown, Cystic Degeneration of Cornea and Sciera. W. A. Huber, Tulsa, Okla. Philadelphia.—p. 737. 424. •Absorption Rate of Bismuth Compounds. H. J. Templeton and R. —p. B. Intermittent Exophthalmos of One Eye. S. India.— Thomson, Oakland, Calif., and M. Rix, Philadelphia.—p. 739. Sanyal, Calcutta, •Occurrence of in Patients with p. 425. Fungi Malignant Disease. J. A. Fifteenth Phenomenon. Buchanan, New York.—p. 757. Early Century Reference to Interesting Ocular of A. Brav, Philadelphia.—p. 425. List Cutaneous Irritants. L. F. Weber, Chicago.—p. 761. •Hepatorecurrent Syphilis: Case Terminating in Acute Yellow Atrophy. S. S. Greenbaum, Philadelphia.—p. 771. American Journal of Psychiatry, Baltimore •Subcutaneous Cysticercosis Cellulosae in Man: Five Cases. C. Hu, 9:779-1042 (March) 1930 O. Khaw and C. N. Frazier, Peiping, China.—p. 777. Coccidioidal Granuloma. H. New Statistic System of Massachusetts Department of Mental Diseases. P. Jacobson, Los Angeles.—p. 790. N. A. 779. Cutaneous Melanoma. S. W. Becker, Chicago.—p. 818. Dayton, Boston.—p. •Comparative of Kahn Pathologic Changes in Region of Tuber Cinereum in Idiopathic Epilepsy. Study and Hinton Reactions. N. Nagle and J. C. L. and H. 805. Willett, St. Louis.—p. 836. O. Morgan S. Gregory, Chicago.—p. Lichen Problems in of H. M. Spinulosus Following Intradermal Application of Diphtheria Delinquency: Causation Stealing. Tiebout, New Toxin. S. W. Becker, Chicago.—p. 839. York.—p. 817. Anatomicoclinical Observations on Myoclonus in Epileptics and Related Cutaneous Manifestations of Heredity. Williams Symptom Complexes. M. B. Hodskins and P. I. Yakovlev, Palmer, believes that a knowledge of the of diseases— 827. heredity of the skin Mass.—p. may be of value in Psychiatric Aspects of Crowded Living Conditions. J. S. Plant, Newark, great dealing with patients suffering from N. J.—p. 849. them, who always want to know if their children will be victims Psychopathology of Marital Maladjustment. G. K. Pratt, New York. of the same curse. An exact answer can seldom be but 861. given, —p. the more nearly complete the physician's knowledge, the greater Microcephaly Following Embryonic Roentgen Irradiation: Case. E. A. will be his Doll, Vineland, N. J., and D. P. Murphy, Philadelphia.—p. 871. confidence in reassuring his questioner in some cases, or in explaining that though a disease belongs in the hereditary American Journal of Surgery, New York group, the chances of an individual child suffering from it may 8: 743-952 (April) 1930 be very small. Chronic Leg Ulcers: Treatment with Unna's Paste Boot. R. A. Cutting, Absorption Rate of Bismuth Compounds.—Studies have New 743. Orleans.—p. been made by Templeton et al. of the rate Surgical Aspects of Biliary Disease. R. S. Fowler, New York.—p. 750. absorption of seven¬ Treatment of Acute Appendicitis. E. T. Crossan, Philadelphia.—p. 759. teen different brands of bismuth in man. The absorption rate Extra-Articular Arthrodesis of Hip by Bone Graft for Tuberculosis of of fifteen of these brands has also been determined in the Hip. F. H. Albee, New York.—p. 764. experimental animal The results ^Cuticular Suture. M. Tomaiuoli, New York.—p. 770. (rabbit). in rabbits are so at variance Treatment of Acute Head Injuries. C. W. Rand, Los Angeles.—p. 772. with the results in patients that future similar studies Spinal Anesthesia. F. T. Romberger, Lafayette, Ind.—p. 773. should be on patients, not on rabbits. in K. P. N. Hypertonie Saline Solutions Infections. Neal, Raleigh, C. Occurrence of in Patients with —p. 780. Fungi Malignant Dis¬ Shoulder Pain. M. Cleveland, New York.—p. 783. ease.—Buchanan reports that the saliva of forty-eight patients Simplified Method of Traction for Finger Fractures. W. H. Robinson, with malignant disease was positive for fungi. In two Pittsburgh.—p. 791. only instances was the saliva for Clinical and Pathologic Aspects of Appendicitis. B. Portis, Chicago.— negative fungi. The urine and p. 793. saliva in all instances gave a positive reaction to the bichromate Surgical Importance of Occasional Communications Between Synovial test. The test is not indicative of malignant disease but shows Sacs of Knee and Proximal Tibiofibular Joints. C. Weeks, New York. fermentative processes going on in the stomach and the intestine —p. 798. Operative Injury of Ureter: Five Cases. A. Harris, New York.—p. 801. of the patient, either as a specific expression or as an associated Tuberculosis of Vaginal Tract. W. H. Barnes, Oakland, Calif.—p. 810. phenomenon. Mediastinitis Following Removal of Thyroid. F. S. Mainzer, Clearfield, Pa.—p. 817. Hepatorecurrent Syphilis.—An instance is reported by Foreign Bodies in Brain. L. Dretzka, Detroit.—p. 819. Greenbaum of hepatorecurrence terminating in acute yellow Uterine Polyposis: Malignant Transformation with Pulmonary Metas- atrophy in a patient who three and one-half months previously tases. W. T. Dannreuther, New York.—p. 824. received four small intravenous injections of Rectal Adenomatous Polyp with Carcinomatous Degeneration. D. H. neoarsphenamine Bessesen, Minneapolis.—p. 829. for secondary syphilis. Intravenous injections of sodium thio- Fibro-Adenoma in Accessory Breast. R. J. White, Fort Worth, Texas. sulphate, dextrose and sodium iodide and a single intramuscular —p. 830. injection of bismuth did not stay the progress of the disease. Simple Lateral Luxation of Atlas. A. N. Foxe and L. J. Friedman, use of the bismuth and New York.—p. 831. The slow-acting drugs, mercury, appears Osgood-Schlatter's Disease. G. H. V. Hunter, New York.—p. 833. inadvisable in clear cut instances of hepatorecurrence. Arsenical Vesical Neck Obstruction with Large Vesical Calculus, Bilateral Hydro- therapy in maximum tolerated doses is not always contraindi- Ureters. C. G. Bandler and J. A. Hyams, New 836. York.—p. cated in with syphilis who icterus one or more Headache (Post-Traumatic) Relieved by Lumbar Air Insufflation: Case. patients develop H. L. Skinner, Savannah, Ga.—p. 842. months after the last treatment. This is especially true of Fundamentals in Roentgenology of Colon. J. T. Case, Chicago.—p. 844. those whose course of treatment had been insufficient.

Downloaded From: http://jama.jamanetwork.com/ by a University of Arizona Health Sciences Library User on 05/29/2015 Subcutaneous Cysticercosis Cellulosae in Man.—Six the only therapeutic agent to rely on. General medical care is cases of cysticercosis cellulosae, five of the subcutaneous and always of high importance. Diathermy, with proper technic, muscular tissues, and one of the cerebral cortex, in Chinese is indicated in all forms of pneumonia except in aspiration patients in North China are reported by Hu et al. These were pneumonia, and in pneumonic complications (closed empyema, collected over a period of ten years and represent an incidence pulmonary abscess and deconipensated heart). Diathermy treat¬ ment of about 1 in 25,000 patients. In a series of 143 cases of has proved a good prophylaxis against complications and intestinal teniasis, approximately 90 per cent of forty-nine appears to be of value in treating some of the postpneumonic differentiated cases were due to Taenia saginata. Of the complications (unresolved pneumonia, asthmatic bronchitis and remaining five cases in which Taenia solium was present, chronic bronchitis). Cysticcrais cellulosae was also harbored in two. The charac¬ Health teristics of the cysts when they are located in subcutaneous Canadian Public Journal, Toronto 31: 157-208 1930 tissue are such as to make their identification possible by (April) of and for with examination alone. are as movable as a Preparation Budget Satisfactory Apportionment City physical They freely Full-Time Health Department. F. Adams, Windsor, Ont.—p. 157. foreign body, of elastic hardness,, nontender and, as a rule, ^Preservative Effect of Chlorine Compounds in Milk. C. K. Johns, multiple and more or less uniformly small, the average being Ottawa, Ont.—p. 162. of M. D. about 1 cm. in diameter. Cutaneous sensitization tests per¬ Aspects ^Industrial Nursing. MacDermot.—p. 169. Comment on Cancer and Tuberculosis. J. Miller, Kingston.—p. 174. formed on two of the with the fresh fluid from a patients cyst Dominion Medical Service. J. W. Mclntosh, East Burnaby, B. C.— gave negative results. p. 177. Comparative Study of Kahn and Hinton Reactions.— Preservative Effect of Chlorine Compounds in Milk.— In 748 tests made and Willett with the comparative by Nagle The preservative effect in milk of two hypochlorite and two Kahn and Hinton 363 serums were with the methods, positive chloramine products was compared by Johns with that of Kahn reaction and 299 were with the Hinton reaction. positive formaldehyde. Formaldehyde was found to be a much more The clinical histories secured in of the forty-four seventy-four effective milk preservative than any of the chlorine products cases giving divergent serologie reactions showed the Kahn studied. Equivalent concentrations of chlorine compounds and test in reactions in cases resulting thirty-eight positive syphilitic of formaldehyde vary considerably in their effect on the flavor Hinton with negative reactions, and the Hinton test resulting of milk. vertical concentration (i. e., maximum concentration in two reactions with The positive negative Kahn reactions. not detectable by taste after eighteen hours at less than 60 F.) Kahn test three one reactions and the Hinton test gave plus was established for each compound, and the influence of such one four reaction in cases not as plus diagnosed clinically critical concentration was studied. When added to freshly Hence, the Hinton test was not to the syphilis. comparable drawn milk which was quickly cooled, the influence of the Kahn test in sensitiveness and practicability. critical concentration of each of the chlorine compounds eighteen Arch, of Omaha hours later was relatively slight. When added to milk which Physical Therapy, X-Ray, Radium, was not promptly cooled, the effect was more noticeable ; yet 11: 145-197 (April) 1930 the bacterial count increased so greatly as to preclude any Physical Therapy Indications in Gynecology. J. E. G. Waddington, Detroit.—p. 145. possibility of chlorine preservatives taking the place of prompt •Diathermy in Pneumonia. F. B. Freeland, Portland, Ore.—p. 150. and thorough cooling. The influence of immediate cooling in •Diathermy and Other Physical Agents in Treatment of Pneumonia and prolonging the inherent germicidal action of milk is Sequelae. . A. Lilien, New York.—p. 155. clearly Seminal Vesiculitis; Treatment with Diathermy. W. S. Pugh, New shown in the final series of experiments and illustrates the loss York—p. 162. in keeping quality wdiich follows delay in cooling the milk. Physical Therapy in Gastro-Intestinal Disease. L. II. Levy, New York, —p. 165. Colorado Denver High Frequency Curi cut in Treatment of Chronic Endocervicitis. M. N. Medicine, llvunis. .W-w York.—p. 171. 37: 145-172 (May) 1930 Use of Physical Therapy in Traumatic Cases. E. H. Rebhorn, Scranton, General Clinical Aspects of Syphilis. A. J. Markley, Denver.—p. 148. l'a.—p. 179. Laboratory Diagnosis. P. Hillkowitz, Denver.—p. 149. Status of Roentgen Therapy. . II. lirondo, Detroit.—p. 18S. Treatment of Early Syphilis. J. B. Davis, Denver.—-p. 151. Clinical Types of Neurosyphilis. G. S. Johnson, Denver.—p. 153. Diathermy in Pneumonia.—It has been Freeland's experi¬ Pathology of Cardiovascular Syphilis. \V. S. Dennis, Denver.—p. 155. ence that during the stage of congestion, diathermy gives the Syphilis of Eye. W. M. Bane, Denver.—p. 158. best results when applied intensely and at frequent intervals, from two to four times daily, a current of high heat quality Florida M. Assn. Journal, Jacksonville being used for periods of from thirty to forty-five minutes, IB: 443-478 (April) 1930 with large electrodes covering the chest, placed anteropos- Few Points About Foreign Bodies in Lower Air Passages: Two Cases. M. A. Lischkoff, Pensacola.—p. 443. Under this use of chest the teriorly. general diathermy impend¬ Sterility in Female. A. R. Haisfield, Pensacola.—p. 444. ing pneumonia literally melts away, the lungs promptly clear up Rickets. J. H. Fellows. Pensacola.—p. 447. and the fever disappears. By the application of intense Genital Lesions. T. E. Blackshear, Pensacola.—p. 448. the channels Impressions and Observations Regarding Blood Pressure. C. C. Webb, diathermy during pulmonary congestion lymph Pensacola.—p. 450. and capillaries surrounding the inflammatory area are dilated, Bronchial Asthma. C. J. Heinberg, Pensacola.—p. 451. vasomotor function is normalized, stasis is removed, the blood flow gradually reaches equilibrium, extravasation into surround¬ Georgia M. Assn. Journal, Atlanta ing tissues ceases, and the edema subsides and carries soluble 19: 128-174 (April) 1930 toxins away with it to be destroyed. During the stage of Complications of Gastric Ulcer. R. H. Chancy, Augusta.—p. 128. gray hepatization and early resolution, when toxic absorption is New Conception of Bright's Disease. J. W. Daniel, Savannah.—p. 133. Omentopexy in Cirrhosis of Liver in Children: Case. G. Y. the affected bacteria and laden area Massenburg, a real danger, pus should Macon.—p. 137. be carefully avoided and diathermy directed cautiously toward Tularemia: Case. W. G. Elliott, Cuthbert.—p. 138. any outlying edema in relatively unaffected lobes and by a special technic as a myocardial stimulant. During delayed Iowa State M. Soc. Journal, Des Moines resolution it may again be directed to the affected area, to be 30: 149-192 (April) 1930 diminished in intensity or perhaps discontinued should symptoms New State Maternity Welfare Program. E. D. Plass, Iowa City.—p. 157. Deafness. of toxic absorption appear. Progressive R. M. Lapsley, Kcokuk.—p. 160. Problems in Control of Acute Infectious Diseases in Rural Districts of Diathermy and Other Physical Agents in Treatment Iowa. B. L. Eiker, Leon.—p. 163. of Pneumonia and Sequelae.—Lilien feels that diathermy is Aspects of Chronic Nephritis. E. P. Scarlett, Iowa City.—p. 167. Disease: Case. J. W. Budd, Iowa 171. valuable in the treatment of pneumonia. Its effects are due to Schilder's City.—p. Alterations in Gastric Function Induced by Stimulation from Colon and action of heat on the metabolic as the physical processes well Appendix. F. M. Smith, W. D. Paul and W. M. Fowler, Iowa City. as on the action of enzymes. But, he says, diathermy is not —p. 172.

Downloaded From: http://jama.jamanetwork.com/ by a University of Arizona Health Sciences Library User on 05/29/2015 Baltimore than theophylline and theobromine sodiosalicylate. Toxic symp¬ Johns Hopkins Hospital Bulletin, toms its 4 : 259-306 (April) 1930 (nausea and vomiting) occurred infrequently during administration and were transient. It to be more Circulatory Failure of Diphtheria: II. Carbohydrate Metabolism in appeared Diphtheria Intoxication. F. F. Schwentker and W. W. Noel, Balti¬ easily tolerated than theophylline and theobromine sodio¬ more.—p. 259. salicylate. Diuresis usually begins during the first twenty-four from Tract: and of Resorption Biliary Morphology Permeability Cystic hours of but it not reach a maximum until Epithelium. W. L. Winkenwerder, Baltimore.—p. 272. administration, may •Guanidine Base Concentration in Blood of Normal Individuals and in after it has been given for several days. The author states that Patients with Liver Injury. R. Ellsworth, Baltimore.—p. 296. the drug can be given as long as diuresis lasts. It may be given as as intake. Guanidine Base Concentration in Blood of Normal long it maintains the output of urine near the fluid Individuals and in Patients with Liver Injury.—Blood Liver Function in Congestive Heart Failure. In a — guanidine determinations were made by Ellsworth on twenty- series of 231 patients with congestive heart failure, Jolliffe cent. five persons without hepatic or renal disease. By the method found the frequency of clinical jaundice to be 2.1 per some alteration in liver employed, the guanidine base values varied from 0.37 to 0.58 mg. Fifteen of the sixteen patients had function. No characteristic liver in chronic per hundred cubic centimeters of whole blood. Guanidine type of dysfunction was found. Three showed one estimations on five patients with obstructive and hemolytic passive congestion subjects only abnormal to liver function tests. one jaundice fell within the normal range. In five cases'of Laènnec response Only subject showed all four tests abnormal. No between the cirrhosis of the liver and in one of "Banti's disease," there parallelism of heart failure and of liver function could was a moderate but definite increase in blood guanidine. In six degree impairment be noted in individual cases. Patients die showing little altera¬ cases of arsphenamine jaundice, there was a moderate to con¬ tion in function. marked func¬ spicuous increase in blood guanidine, which fell to normal liver Patients improve showing tional liver Patients with marked failure during recovery. The maximum concentration of blood guani¬ impairment. congestive not show liver As a group there is, dine was higher in the severe cases than in the mild ones. In may any dysfunction. a between the in liver function and one of the severe cases, the fall of blood guanidine just preceded perhaps, parallel changes the of edema and size of the liver. liver the clinical signs of improvement. These observations on degree Any dysfunc¬ patients with arsphenamine jaundice, in which diffuse liver tion induced by an attack of chronic passive congestion is not permanent. Liver still in evidence injury is known to occur, and in patients with Laënnec cir¬ apparently dysfunction rhosis of the liver, together with the observations of Minot after recovery from an attack of chronic passive congestion indicates an liver and Cutler in dogs, indicate that diffuse liver injury is an probably independent impairment. important factor in producing an increase in blood guanidine. Circulatory Measurements in Patients with Rheuma¬ tic Heart Disease Before and After Administration of of Clinical Baltimore Digitalis. Repeated circulatory measurements were per¬ Journal Investigation, — 8:291-484 (April 20) 1930 formed by Weiss and Ellis before and after digitalization in •Congestive Heart Failure: II. Respiratory Exchange During and After four patients with rheumatic heart disease. The patients were Exercise. T. R. Harrison and C. Pilcher, Nashville, Tenn.—p. 291. comfortable at rest, exhibited no clinical evidence of congestive Id.: III. Buffering Power of Blood and Tissues. C. Pilcher, G. Clark but showed marked reduction in their functional capacity and T. R. Harrison, Nashville, Tenn.—p. 317. failure, on muscular all the Id. : IV. Potassium Content of Skeletal and Cardiac Muscle. T. R. attempting any activity. Although patients Harrison, C. Pilcher and G. Ewing, Nashville, Tenn.—p. 325. showed clinical improvement as a result of the administration Relationships Between Plasma Specific Gravity, Plasma Protein Content of the cardiac the of blood the New digitalis, output, velocity flow, and Edema in Nephritis. N. S. Moore and D. D. Van Slyke, and the vital of the York.—p. 337. circulating blood volume capacity lungs Urea Excretion: VI. Comparison of Blood Urea Clearance with Certain showed no significant changes. The evidence presented in this Other Measures of Renal Function. D. D. Van Slyke, J. F. Mclntosh, study and previous observations reported in the literature do E. R. Hannon and New 357. Möller, R. C. Johnston, York.—p. not the that the rate of blood flow is Icterus Neonatorum: Production of Icterus in Animals Following Pro¬ support conception to rheumatic longed Anoxemia. A. Goodbloom and R. Gottlieb, Montreal.—p. 375. increased in circulatory failure due heart disease, •Use of Theocalcin in Treatment of Heart Failure of Congestive Type. nor that the beneficial effect of digitalis is manifested by its H. J. Stewart, New York.—p. 389. capacity to reduce the cardiac output. •Liver Function in Congestive Heart Failure. N. Jolliffe, New York. —p. 419. •Circulatory Measurements in Patients with Rheumatic Heart Disease Journal of Experimental Medicine, Baltimore Before and After Administration of Digitalis. S. Weiss and L. B. 51: 675-830 (May 1) 1930 435. Ellis, Boston.—p. of Pneumococcus Human Whole Blood: I. Normal Full Phagocytosis by Circulatory Changes After Therapeutic Doses of Digitalis with Titer and Antiphagocytic Effect of Specific Soluble Sub¬ Views on Cardiac W. Dock and M. L. Phagocytic Critical Discussion of Output. stance. H. K. Ward, Boston.—p. 675. Tainter, San Francisco.—p. 467. Id.: II. Neutralization of Antiphagocytic Action of Specific Soluble 685. and After Exercise in Substance by Antiserum. . . Ward, Boston.—p. Respiratory Exchange During Transmission of Yellow Fever. N. C. Davis, Bahia, Brazil.—p. 703. Congestive Heart Failure.—Harrison and Pilcher conclude Effect of Route of Immunization on Immunity Response to Pneumococcus from their study that subjects with mitral stenosis and only Type I. E. G. Stillman, New York.—p. 721. of Tuberculosis. . B. Lurie, Philadelphia. edema may suffer primarily from inability to increase Experimental Epidemiology slight —p. 729. their cardiac outputs per minute. Subjects with edema and Id. . B. Lurie, Philadelphia.—p. 743. hypertensive heart disease may suffer from (a) a low maximum Id. . B. Lurie, Philadelphia.—p. 753. . B. Lurie, Philadelphia.—p. 769. cardiac output ; (b) impairment of oxygen utilization, so that Id. Experiments with Virus of Poliomyelitis. R. Thompson, New York.— a minute the intake is with given cardiac output per oxygen p. 777. less ; (c) diminished buffering power of the tissues. In patients Methods for Pure Culture of Certain Protozoa. R. W. Glaser and N. A. N. 787. who have had edema of severe degree for a long time, the Coria, Princeton, J.—p. Gradient of Vascular Permeability. P. Rous, H. P. and F. as not Gilding limiting factor, so far gas exchange is concerned, does Smith, New York.—p. 807. appear to be decreased oxygen intake but inability to acquire • a large (normal) oxygen debt, and this discrepancy is believed Journal of Industrial Hygiene, Baltimore to be due to impairment of tissue buffering power. 12: 75-122 (March) 1930 Use of Theocalcin in Treatment of Heart Failure of Control of Silicosis Hazard in Hard Rock Industries: I. Laboratory Sixteen from heart Study of Design of Dust Control Systems for Use with Pneumatic Congestive Type. patients suffering Tools. T. Hatch, P. Drinker and S. P. — Granite Cutting Choate, failure of the congestive type were treated with theocalcin by Boston.—p. 75. Stewart. The drug was given by mouth in doses of from ^Comparative Action of Five and Ten Per Cent Carbon Dioxide Mixtures as Stimulants in Carbon Monoxide D. 1.5 Gm. three times a marked diuresis was induced Respiratory Poisoning. P. 1 to day; Murphy and C. K. Drinker, Boston.—p. 92. in the majority of the patients. It was effective when other Quantitative Measurement of Human Efficiency Under Factory Condi¬ therapeutic agents failed and it appeared to be more effective tions. O. S. Lovekin, Boston.—p. 99.

Downloaded From: http://jama.jamanetwork.com/ by a University of Arizona Health Sciences Library User on 05/29/2015 Carbon Dioxide Mixtures as Respiratory Stimulants tory results. The ratio is 1: 10 and the extraction is carried in Carbon Monoxide Poisoning.—A series of twelve adult out at 37 C. for one hour. The extract is filtered, allowed to stand room cats were subjected by Murphy and Drinker to progressive over night at temperature, again filtered and 0.6 carbon monoxide poisoning until death resulted. Inhalation of per cent cholesterol added. The acetone and ether antigens 5 and 10 per cent mixtures of carbon dioxide and oxygen were among the secondary extracts and the plain alcoholic extract permitted at various stages during the progress of the poison¬ have a wider specific zone than the antigens devised by Kahn. The ing in order to determine their relative powers as respiratory preparation of these antigens is well defined. Variations stimulants. Early in the asphyxia, stimulation followed the in the results are comparatively small if mixtures of several inhalation of both mixtures. Later, the 5 per cent mixture beef hearts are always used. Complicated procedures as rec¬ gave no stimulation, while the 10 per cent mixture still elicited ommended by Kahn for the correction of his antigens appear some response. At the end of the experiment, or near the superfluous. The antigen is equally useful in the Wassermann, the Kahn and the author's test. death of the animal, neither of the mixtures was in any way effectual in increasing the ventilation rate. From these obser¬ Incidence of Bacteria in Four Hundred Tonsil Cul¬ vations two conclusions are reached : first, that 10 per cent tures.—In 400 tonsillar cultures examined by Cobe, staphylo- carbon dioxide is more effectual in the treatment of certain cocci were the predominating organisms. The streptococci the degrees of carbon monoxide asphyxia than is the 5 per cent followed pneumococci in predominance, with hemolytic mixture, and, second, that artificial respiration should be admin¬ streptococci the predominant members of the group. Three recovered classed istered to patients who are breathing but who are suffering per cent of the nonhemolytic streptococci were from severe grades of asphyxia. In these persons a brief as Strcplococcus cardioarthritidis. There appears to be a defi¬ period of artificial respiration will induce conditions favorable nite relationship between the type of organism recovered from to the stimulation of breathing by the carbon dioxide in the tonsillar cultures and the age of the patient, streptococci being inhalation mixtures. more common in younger patients (under 11 years of age). There was a definite seasonal difference in the organisms recov¬ Journal of Infectious Diseases, Chicago ered from tonsillar cultures, B. inftttensae, B. mucosus-capsulalus. 4ß: 267-350 (April) 1930 and the diphtheroids all being more prevalent in the spring, Changes in Blood Dextrose and Inorganic Phosphates After Intravenous and Micrococcus catarrhalis more prevalent in the fall. Injection of Paratyphoid Filtrate in Depancreatized Dogs. M. L. Disease of Produced with Cul¬ Menten and H. A. 267. Fusospirochetal Lungs Kipp, Pittsburgh.—p. tures from Vincent's of Chemical Studies on Toxin Produced by B. Paratyphosus (Aertrycke Angina.—Small pieces membrane Type). M. L. Menten and C. G. King, Pittsburgh.—p. 275. from patients with Vincent's angina, inoculated by Smith into Viability of Organism of Rocky Mountain Spotted Fever When Frozen. the of local abscesses which con¬ A. groin guinea-pigs, produced G. King, Boston.—p. 279. tained identical with those in the •Antigens for Precipitation Test for Syphilis. E. Weiss, Chicago.—p. 285. organisms original material. Bacterial Flora in Feces of Normal Fowl. M. W. Emmel, East Lansing, Pus from these abscesses, when introduced into the trachea of Mich.—p. 293. rabbits, produced a series of lesions comparable to those found •Incidence of Bacteria in 400 Tonsil Cultures. M. . Cobe, Philadelphia. in man : gangrene, abscesses and bronchiectasis. —p. 298. pneumonia, *Fusospirochetal Disease of Lungs Produced with Cultures from Vincent's This indicates that these various forms of clinical disease have Angina. D. T. Smith, Ray Brook, . Y.—p. 303. a common etiology in the anaerobic mixture of spirochetes, of •Agglutination Typhoid Bacilli in Serums of Patients Having Unre¬ fusiform bacilli, vibrios and cocci present in Vincent's lated Infections. R. Gilbert and M. B. Coleman, Albany, N. Y.— angina. p. 311. Pure cultures of Treponema microdentium, a small fusiform Microbio Dissociation in Abortus-Melitensis Group. W. N. Plastridge bacillus, a vibrio, and an anaerobic hemolytic streptococcus were and J. G. McAlpine, Storrs, Conn.—p. 315. isolated from the mixture. None of these organisms alone •Action of Bacteriophage and Chemical Disinfectants -on Staphylococcus in Subcutaneous Injections. J. E. Walker, New Brunswick, N. J.— would reproduce the disease, but a mixture of all four resulted p. 324. in a typical fusospirochetal abscess in the groin of mice and •Bacteria of Upper Respiratory Tract and Middle Ear of Albino Rats guinea-pigs. Pus from these abscesses caused fuso¬ Deprived of Vitamin A. R. G. Turner, D. E. Anderson and E. R. typical Loew, Detroit.—p. 328. spirochetal lesions in the lungs of rabbits. Susceptibility of Monkeys, Goats and Small Animals to Oral Administra¬ Agglutination of Typhoid Bacilli by Patients Having tion of Botulinum Toxin, Types B, C and D. J. B. Gunnison and Unrelated Infections.—Observations K. F. San 335. by Gilbert and Coleman Meyer, Francisco.—p. make it evident that the Identity of Bacillus Subtilis. H. J. Conn, Geneva, . Y.—p. 341. results of the agglutination reaction with typhoid bacilli must be interpreted in the light of clinical for Test for Antigens Precipitation Syphilis. An manifestations or of bactériologie observations since it has been has been Weiss — optimal antigen prepared by by extracting shown that agglutination may be encountered in col¬ dried and specimens pulverized beef heart with acetone in the ratio of lected from patients during febrile diseases other than typhoid, 1 : 15 for one hour at room temperature or 37 C. The extract even though the patients have never received typhoid vaccine is then filtered, the filtrate and the moist beef discarded, heart nor to their knowledge have had typhoid, and that a fluctuation in the incubator at 37 C. for one or placed hour, longer, until of the agglutination titer, considered by some as definite evi¬ To the dried beef 95 cent dry. heart, per alcohol is added, dence of typhoid, may occur in cases in which this infection in the ratio of 1:5. This extraction is carried out at 37 C. is quite definitely excluded. for three The extract is days. then filtered and the filtrate Action of Bacteriophage and Chemical Disinfectants is allowed to stand at room temperature over This is night. on Staphylococcus in Subcutaneous Injections.—Various done in order to facilitate the falling out of lipoids which are dilutions of bacteriophage and of several chemical disinfectants soluble in alcohol at 37 C. but not at room The temperature. were mixed by Walker with a definite quantity of staphylococci extract is again filtered and 0.6 per cent cholesterol is added. and injected ¡ntracutaneously into rabbits. The resulting lesions This is to other antigen preferred secondary extracts because gave information concerning the germicidal activity of the of the fact that the use of acetone in the first extractions substances and their comparative toxicity for animal tissues. removal of avoids an excessive suitable lipoids. The acetone The chemicals tested were mercuric chloride, phenol, formal¬ soluble lipoids are useless for precipitation and represent only dehyde, tincture of iodine, and chloramine. Staphylococcus a fraction of those lipoids which are soluble in ether, chloro¬ bacteriophage had a much wider range of dilutions (from full form, benzene and xylene. The secondary extracts are pre¬ strength to 1 : 512) over which the resulting lesions were par¬ pared in the same manner as the optimal antigens, except that tially suppressed without necrosis of the tissue. The nearest the first extraction is carried out with a different solvent at chemical in this respect was mercuric chloride, which could be icebox temperature. This is done in order to avoid an exces¬ diluted to one sixteenth of the strength causing necrosis and sive loss of lipoids which are useful for the precipitation. The still partially suppress the staphylococcus lesion. The results ether antigen among the secondary extracts is satisfactory and afford theoretical support for the view that bacteriophage makes ranks next to the optimal antigen in usefulness. The plain a more suitable local dressing than the chemicals for staphy¬ alcoholic extract prepared from beef heart also gives satis fac- lococcus infections.

Downloaded From: http://jama.jamanetwork.com/ by a University of Arizona Health Sciences Library User on 05/29/2015 Bacteria of Upper Respiratory Tract and Middle Ear 45:843-918 (April 18) 1930 of Albino Rats Deprived of Vitamin A.—Turner et al. Accidental Psittacosis Infection Among Personnel of Hygienic Labora¬ found that the chro- tory. G. W. McCoy.—p. 843. pyogenic gram-negative cocci, especially •New Meningococcus-Like Organism (Neisseria Flavescens N. Sp) from mogen 6, are encountered more frequently in the animals that Epidemic l· eningttis. S. E. Branham.—p. 845. show the most severe symptoms of vitamin A deficiency. It Seamen with Venereal Disease in Port of New York. A. M. Stewart, is believed that these organisms gain a pathogenic hold during —p. 850. the depressed state of their host resulting from vitamin A New Meningococcus-Like Organism from Epidemic deficiency. Evidence is given that cod liver oil protects against Meningitis.—During an epidemic of cerebrospinal meningitis bacterial invasion of the nasal cavities and middle ear. in which all four of the usual types of meningococci were involved, an apparently new form was isolated by Branham Kentucky Medical Journal, Bowling Green from the spinal fluid in fourteen cases. In morphology this 38: 217-266 (May) 1930 micro-organism is indistinguishable from the other members of Clinical Course and Treatment of Influenza. W. J. Shelton, Mayfield. the genus Neisseria. It differs from the meningococcus in p. 219. pigment production, in lack of fermentative and in anti- — action, Roentgen Diagnosis of Complications of Influenza. C. D. Enfield, Louisville.—p. 222. genic relationship. These fourteen strains form a homogeneous Empyema and Influenza. E. S. Allen, Louisville.—p. 224. group culturally, biochemically and serologically. The name Ear Complications of Influenza. J. W. Nolan, Harlan.—p. 227. Neisseria flavescens n. sp. is proposed for this new form. Psychoses Following Influenza. H. B. Scott, Louisville.—p. 229. Use of Skin Grafts in Plastic Surgery. F. M. Massie, Lexington.— Virginia Medical Monthly, Richmond p. 238. 57: 1-70 (April) 1930 255. Mammary Carcinoma. S. Anderson, Louisville.—p. Recent Advances in Internal Medicine. H. B. Mulholland, University, Importance and Clinical Significance of Basal Metabolism Studies. 1. E. F. 261. -p. Horine, Louisville.—p. Recent Progress in Surgery. G. P. LaRoque, Richmond.—p. 4. Vaginal Hysterectomy: Indications and Technic J. S. Horsley, Rich¬ New England Journal of Medicine, Boston mond.—p. 11. 203:797-842 (April 24) 1930 Examination of Preschool Child. W. A. Brumfield, Farmville.—p. Iß. Observataions on Points of with in Interest in Dealing Problems of Child Use of Fasciai Strips Repair of Recurrent Inguinal Hernia. E. M. Welfare. H. 20. 797. J. Hiden, Pungoteague.—p. Hodgkins, Boston.—p. Child Welfare: What is Being Done in Field of Child Conservation. Constipation in Children: Treatment by Use of Residue-Free Diet. A. T. Finch, Chase 23. R. M. and H. E. 802. City.—p. Smith Gallup, Boston.—p. Vagitus Uterinus. M. P. Rucker, 26. Bladder from Diverticulitis of Sigmoid. F. H. Boston. Richmond.—p. Symptoms Colby, Malignant Hypertension in Young People. D. Davis and D. Vander- —p. 805. 31. Test for of Heart. hoof, Richmond.—p. Pump Functional Reserve Combined Cardiodyna- Portion of Safety Pin in Right Main Bronchus: Removal: Bronchoscopy. mometer and Accessory Blood Pressure Air Tank. A. S. Hyman, E. G. 33. New 807. Gill, Roanoke.—p. York.—p. Findings in Clinical of Ascaris in Chorion Case. 810. Pulmonary Study Infestation Chil¬ Carcinoma: D. J. Duggan, Boston.—p. dren. C. W. Scott, 34. Tannic Acid Treatment of Cutaneous Burns. F. W. New Richmond.—p. Bancroft, Use of and Indications for Forceps. R. P. Kelly, Lynchburg.—p. 38. York.—p. 811. Coronary Disease. W. P. Adams, Norfolk.—p. 40. Neuritis. R. F. Gayle, Jr., Richmond.—p. 43. Ohio State Medical Journal, Columbus Stenosis of Pylorus with Spasm and Hypertrophy in Adults: Surgical 36: 377-472 (May 1) 1930 Aspects. C. B. Morton, University.—p. 46. Use of Controllable Spinal Anesthesia in Five Hundred Major Opera¬ tions. J. L. DeCourcy, Cincinnati.—p. 397. Streptococcic Meningitis: Recovery. H. D. Cassel, Dayton.—p. 401. FOREIGN Proptosis in Sinus Disease. D. T. Vail, Jr., Cincinnati.—p. 403. An asterisk (*) before a title indicates that the article is abstracted Infection of Upper Urinary Tract in Pregnancy. P. A. Jacobs and below. Single case reports and trials of new drugs are usually omitted. W. Rosenberg, Cleveland.—p. 408. Poison in Shoe Industry. C. L. Ferguson, Portsmouth.—p. 410. British J. Actinotherapy & Physiotherapy, London Renal Tuberculosis. V. C. Hunt, Rochester, Minn.—p. 411. 5: 1-22 (April) 1930 Fundamental Principles of Radiation Therapy. A. Eidinow.—p. 3. Islands M. Assn. Manila Medical Uses of Rays of Four to Eight Angstrom Units. J. Saidman. Philippine Journal, 4. 10: 105-148 (March) 1930 —p. Pyretic Treatment of Rheumatic Conditions. C. E. Sundell.—p. 6. •Status of Eclampsia in Philippines. H. Acosta-Sison and A. Baens.— Interaction of Ultraviolet and Infra-Red Rays. R. K. Brown.—p. 8. p. 105. South Africa as Climatic Resort. T. W. B. Osborn.—p. 9. Problems in Filipino Nutrition. F. O. Santos.—p. 121. Proposed Physical Treatment Center at Bermondsey. D. M. Connan.— Acetic Acid in Treatment of Trachoma. C. D. Ayuyao.—p. 129. p. 11. Effect of Different Doses of Quinine Sulphate on Decrease in Malarial Local Treatment with Radioactive Substances. G. Singer.—p. 11. Parasites in Peripheral Blood. S. S. Bernardo.—p. 132. Theoretical and Practical Observations on Springs of Luhacovice. S. Frankl.—p. 12. in to Status of Eclampsia Philippines. According Medical Review of British Spas: IX. Droitwich.. M. B. 13. — Ray.—p. Acosta-Sison and Baens, the incidence of eclampsia in the Philippine General Hospital among 17,661 parturients admitted British J. Exper. Pathology, London during the decade 1919 to 1928 was 1.18 per cent. The inci¬ 11: 64-136 (April) 1930 dence of eclampsia among twin pregnancies was 11.31 per cent. Effect of Irradiation on Cobra Venom and Antivenin. A. Eidinow.—p. 65. Reaction of Isolated Uterus of Rat. C. H. were affected two and one-half times as often as Anaphylactic Kellaway.—p. 72. Primíparas Carotene and Vitamin A: Anti-Infective Action of Carotene. H. N. multíparas. The time incidence of eclampsia in the Philippines Green and E. Mellanby.—p. 81. does not correspond to its seasonal occurrence in temperate Variations in Phosphatase Activity of Blood in Disease. W. M. Roberts. climates but is most prevalent, in order of frequency, during —p. 90. Vaccinal Immunity in Rabbits by Means of in Vitro Methods. S. R. the months of January, May, December, March and August. Douglas and W. Smith.—p. 96. Of the three varieties of eclampsia the intrapartum is the com¬ Typhoid Agglutination After Oral Immunization. A. Pijpe and H. Dau. monest, but it exceeds the antepartum by only a small margin. —p. 112. The has the Excretion of Insulin in Urine. R. D. Lawrence, K. Madders and H. R. antepartum highest mortality. Postpartum eclamp¬ Millar.—p. 117. occurs and has the lowest sia least frequently mortality. The 'Experiments on Cultivation of Vaccinia Virus. H. B. Maitland and commonest early symptoms noted, in order of frequency, were A. W. Laing.—p. 119. edema, constipation, albuminuria, raised blood pressure, head¬ •Occurrence of Influenza Bacilli in Mouths of Normal People. A. Fleming and I. H. MacLean.—p. 127. dizziness, and nausea and vomiting. ache, Electric Charge of Yellow Fever Virus. E. Hindle and G. M. Findlay. —p. 134. Public Health D. C. Reports, Washington, Experiments on Cultivation of Vaccinia Virus.—Mait¬ 45: 773-841 (April 11) 1930 land and Laing discuss the cultivation of vaccinia virus in a Psittacosis: Rickettsia-Like Inclusions in Man and Experimental Ani¬ of minced hen's serum mals. R. D. Lillie.—p. 773. medium consisting kidney and Tyrode's Seamen with Venereal Disease in Port of New York. A. M. Stewart, solution. The virus has been carried through twenty-one suc¬ —p. 778. cessive cultures. In almost all sets of cultures the virus

Downloaded From: http://jama.jamanetwork.com/ by a University of Arizona Health Sciences Library User on 05/29/2015 increased from 10 to 1,000 times or more. Comparatively little nitrites—a dangerous procedure in view of the low blood pres¬ virus served to initiate growth. During cultivation the virus sure. The crescendo character of the pain, its duration, the has maintained its ability to produce typical lesions in the skin fact that it is not relieved by rest and that the attack frequently of rabbits. Subcultures of the virus have been made after occurs when the patient is resting and is in no way attributable storage for 191 and 128 days. Samples have ieen infective to exertion, are important. The fall in blood pressure, and the when tested after storage for from five to 358 days. In view shock, prostration and vomiting which generally accompany the of the regularity with which cultures have been obtained, the pain, serve to distinguish it from true angina, as do the feeble potency of culture virus and the maintenance of its infectivity first heart sound, the gallop rhythm, the rapid pulse and the during storage, the freedom of the culture from bacterial con¬ pericardial friction which are sometimes present. Even in the tamination, and the small cost entailed, this or a similar method most desperate cases recovery may take place, especially when of culture suggests itself as being suitable for the production the patient is under 50 years of age. of "vaccine" on a larger scale. Coronary Arteries in Case of Familial Liability to Occurrence of Influenza Bacilli in Mouths of Normal Sudden Death.—Herapath and Perry had an opportunity to Persons.—By the use of penicillin, hemoglobinopbilic bacilli examine the heart of a man, aged 43, who had died suddenly, have been isolated by Fleming and MacLean from the gums of as had his father (aged 42) and two brothers (aged 30 and 31, all of thirty healthy nurses and students, and from the tonsils respectively). The cause of death would appear to have been and postnasal spaces of almost all of these. The majority of impairment of the coronary circulation due to degenerative the strains isolated were nonhemolytic, but hemolytic strains changes in the coronary arteries. The pathologic process corre¬ were found in all situations. Para-influenza as well as influenza sponds with that of a premature senility of the arterial tree, bacilli were isolated from all these situations. A bacillus agree¬ with a particular incidence in the coronary arteries. There ing in its (growth) requirements with B. hacinoijlobinophilus- was no evidence of any infective factor. canis was isolated from the gums of one individual. From the Effects of Air in Vascular System and Mechanism of gums of six laboratory workers who were studied carefully, Death.—Barry has demonstrated experimentally that dogs can both influenza and para-influenza bacilli were isolated. The recover from the effects of introducing about 100 cc. of air into hemoglobinophilic bacteria isolated were variable in their cul¬ the jugular vein. Resistance to the effects is diminished in tural and morphologic characters. A type of para-influenza deep anesthesia and after section of the vagi. The heart in bacillus which was constantly found in the gums is described. some conditions is the organ that fails in fatal cases, but failure From the apexes of infected teeth, hemoglobinophilic bacilli of the respiratory center is the cause of death in others. Apnea were isolated in three cases out of four. The methods of using is an important symptom indicating the loss of reaction in this penicillin for the isolation of influenza bacilli are described. center. Ventricular fibrillation is not a common cause of death. With regard to treatment, the inhalation of oxygen while the British Medical Journal, London respiratory center is active is indicated. Artificial respiration should be tried when it shows of failure. As for bleeding 1: 677-726 (April 12) 1930 signs and little faith. out that •Relation of Diet to Health and Disease. E. Mellanby.—p. 677. aspiration, they inspire Barry points •Coronary Occlusion. C. Bramwell.—p. 681. experimental animals exhibit marked powers of natural recovery, •Coronary Arteries in Case of Familial Liability to Sudden Death. C. E. and one is prone to attribute to some remedial measure an undue K. Herapath and C. B. Perry.—p. 685. beneficial effect. Use of Surgery in Pulmonary Tuberculosis. IL M. Davies.—p. 687. •Effects of Air in Vascular System and Mechanism of Death. D. T. Treatment of Desperate Cases of Diabetic Coma.— Barry.—p. 689. Attention is drawn by Lawrence to dehydration as being the •Treatment of Desperate Cases of Diabetic Coma. R. D. Lawrence.— immediate cause of death from circulatory failure in desperate p. 690. lliliary Cirrhosis in Elderly Woman. J. N. Banks.—p. 692. cases of diabetic coma. Such patients die, as do those with Strangulated Hernia in Infant. T. W. Meihuish.—p. 693. cholera, from depletion of tissue and blood fluids, and often in A. B. Death During Spinocaine Anesthesia. Hudson.—p. 693. the anurie state. The condition is recognized clinically by a Relation of Diet to Health and Disease.—Mellanby again feeble, empty pulse, shrunken tissues, low eye tension, and calls attention to his study of the action of vitamin A in puer¬ oliguria or anuria. In addition to insulin they require imme¬ peral septicemia. Of twenty-two patients who had entered the diately large quantities of fluid, preferably administered intra¬ institution where the investigation was carried out in the two venously. A treatment with hypertonic saline solution and acacia years prior to the new treatment, twenty died, a mortality of solution is described. 91 per cent. Of nine patients treated from the beginning with vitamin A, eight have made complete recoveries. There have Journal of Pathology & Bacteriology, Edinburgh 233-500 also been two other septicémie patients, one with an infection 33: (April) 1930 Intrathoracic caused Bacillus who and the other with a *Primary Malignant Tumors. J. Maxwell.—·-p. 233. by coti, recovered, Tumor of Liver the total eleven •Embryonic Containing Striated Muscle. H. L. Sheelian. staphylococcic infection, who died. Thus, of —p. 251. patients, two have died, giving a mortality rate of 18 per cent, •Diffuse Tuberculous Infiltration of Myocardium: Unusual Case. J. G. as compared with the mortality rate of 91 per cent in the control Thomson.—p. 259. is Antivaccinial Serum: 3. Evidence for Slow Union with Virus in Vitro. group. Mellanby thinks there strung evidence, especially C. H. Andrewes.—p. 265. taken in conjunction with the results in animals, that vitamin A Specific Antibody Absorption by Viruses of Vaccinia and Herpes. W. has a definite effect in raising the resistance of the body, both Smith.—p. 273. •Multiple Malignant W. 283. human and animal, to bacterial agencies, and that, in its absence Neoplasms. J. Orr.—p. *Fatal Granulomatosis of Central Nervous System Due to Yeast (Tortila). from or deficiency in the body, the resistance to infection of F. . Smith and J. S. Crawford.—p. 291. this type is greatly diminished. Invasion of Epidermis by Carcinoma. .T. S. Dunn.—p. 297. Tissue Culture in Study of Immunity to Herpes. C. H. Andrewes.— endeavors to Coronary Occlusion.—Bramwell show that p. 301. the study of coronary thrombosis is not confined to the post¬ •Inheritance of Blood Group Factors. G. K. Kirwan-Taylor.—p. 313. mortem room. It is a definite clinical entity, which, in a large Fetal Rickets: Two Cases. J. P. Maxwell.—p. 327. Role of Spleen in Production of Antibodies. W. W. C. 339. of can be with Topley.—p. percentage cases, recognized certainty during Toxicity of Irradiated Ergosterol. J. B. Duguid, . M. Duggaii and life. Its recognition is important, because many of the patients J. Gough.—p. 353. survive, and a few are sufficiently restored to health to resume Epithelial Proliferation in Lung of Rabbit Brought About by Tntrapleural their former occupations. Further, a correct diagnosis is of Injection of Solutions of Electrolytes. J. S. Voting.—p. 363. Métastases of Cerebral Glioma of Known as not in the but •Spinai Type Astrocytuma vital importance, merely framing prognosis also Fibrillare: Case. D. S. Russell and H. Cairns.—p. 383. in determining the treatment. An acute coronary occlusion may Genus Willia (Yeasts). J. F. D. Shrewsbury.—p. 393. closely simulate an abdominal crisis, and if the condition is Transplantable Melanoma of Mouse. H. E. Harding and R. D. Passey. 417. a patient may be submitted to laparotomy, which, —p. unrecognized Intravitam and Supravital Staining: IV. Cellular Reactions Following in view of the cardiac lesion, is almost certain to prove fatal. Mild Irritation of Peritoneum in Normal and Vitally Stained Animals. Other cases are mistaken for ordinary angina and treated with D. F. Cappell.—p. 429.

Downloaded From: http://jama.jamanetwork.com/ by a University of Arizona Health Sciences Library User on 05/29/2015 •Acute Disseminated Encephalomyelitis as Sequel to Influenza. J. G. logic examination the tumor was found to be composed entirely Greenfield.—p. 453. of It subarachnoid Experimental Vaccinial Encephalitis in Monkey and Rabbit: Problem of fibrillary astrocytes. had invaded the space Km. |'h;ililis Kulli.u ìiil; Vaccination in Man. E. W. Hurst and R. W. by way of the right pulvinar. Miliary metastatic nodules were Fairbrother.—p. 463. found in the subarachnoid space over the superior medullary Reaction of Central Nervous System to Vaccinia Virus. J. Mclntosh velum and in the subarachnoid of the cord. These and R. W. Scarff.—p. 483. space spinal Primary Carcinoma of Kidney: Case. J. Gray.—p. 489. métastases were entirely composed of fibrillary astrocytes, and Implantation of Secondary Carcinoma Within Intestines. J. H. Teacher. thus presented the same degree of differentiation as did the —p. 491. primary tumor ; they gave rise to no recognizable clinical Gonococcal Complement Fixation Test: Improvements in Technic. 1. X. O. Price.—p. 493. symptoms. Acute Disseminated Encephalomyelitis as Sequel to Primary Malignant Intrathoracic Tumors.—A series of Influenza.—Two cases of acute disseminated encephalomyelitis 239 cases of primary malignant intrathoracic tumors is dis¬ following influenza are described by Greenfield. One was fatal cussed by Maxwell and the histologie appearances are recorded five days and the other seven weeks after the onset of symp¬ in 135 of these cases. Primary bronchial carcinoma was found toms. The lesions found in the nervous system were of the to occur in 184 cases. The chief morbid anatomic changes are same kind as in the encephalomyelitis that sometimes follows described and the microscopic characteristics in 111 cases are vaccination smallpox and measles. These cases are considered discussed; reasons are given for accepting all of these cases to suppcirt the view that acute disseminated encephalomyelitis is as carcinomas in two main groups, an obvious columnar cell a discase per se which may be brought on or directed against group witli a tendency to squamous and a small oval metaplasia the nervous system by certain febrile or exanthematous diseases. cell group which is slightly more common. The oval cell carcinomas are discussed. in detail and reasons are given for London the conclusion that they spring from the basal layer of the Lancet, 1: 843-896 (April 19) 1930 bronchia] It has not been shown that of (he epithelium. any Health in West Africa. D. B. tumors of Blacklock.—p. 843. in this series arose directly in the epithelial lining Impressions of Psychiatry in America. E. Mapother.—p. 848. the pulmonary alveoli. The mediastinal tumors are shown to •Relation of Aceto-Acetic Acid to Diabetic Coma and Cause of Death. be a heterogeneous group, some being the result of infiltration E. C. Dodds and J. D. Robertson.—p. 852. Spinal Cord Tumors. A. M. and L. 854. or metastasis from a small bronchial others Kennedy Rogers.—p. primary focus, 'Presence of Antibodies to Herpes Virus in Postencephatitic and Other living accepted as sarcomas arising in the mediastinal glands. Human Sera. C. II. Andrewes and E. A. Carmicbael.—p. 857. No conclusive evidence could be found to show that any arose •Improved Method of Ligaturing External Carotid Artery. N. Patterson. ». 858. within the thymic remnants. Primary pleural tumors are shown Tonsillectomy by Diathermy Using Surface Anesthesia. W. Collins.— to be a rare but well defined and are group briefly discussed. p. 859. Tumor of Liver Striated Embryonic Containing Relation of Aceto-Acetic Acid to Diabetic Coma and Muscle.—In a the liver contained a number young girl, aged 6, Cause of Death.—A study made by Dodds and Robertson of of cysts lined bile duct The sub¬ papilliferous by epithelium. (<;) the aceto-acetic acid and (/>) the alkali reserve content it' stance of the papillae consisted of undiftcrcntiated cells. These the blood in patients in diabetic coma failed to support the cells in uni.' cyst became malignant and formed a large tumor, theories of kctosis and acidosis, respectively, as a cause of this destroying every oilier tissue except bile duct epithelium and condition. Thus, in many cases noncomatose diabetic patients showing a tendency to intravascular growth but not to metas¬ were found to have a higher aceto-acetic acid content than the tasis outside the liver. They also differentiated into four types comatose patients, and it was found impossible to correlate the of innre mature striated muscle. are cells, including They blood analyses with the clinical condition of the On Vred Sheehan to be rest cells of mesoblast. patient. by recovery from coma, it was found that the aceto-acetic acid Infiltration Diffuse Tuberculous of Myocardium.—In a content rose, thereby further indicating that the enol theory of the of the man, aged 41, subject uveoparotid fever (Heerfordt), diabetic coma is improbable. In the fatal cases it was found lesions were found Thomson mortem: following by post that death was preceded by a persistently falling blood pres¬ 1. Tuberculosis of the lungs apparently of mixed blood and sure, and the importance of circulatory failure is indicated. 2. lymphatic spread. Tracheobronchial and mediastinal glandular The occurrence of leukocytosis in coma is confirmed. tuberculosis. 3. Massive tuberculous infiltration of the septum Presence of Antibodies to Herpes Virus in Posten- and of the greater part of the wall of the left ventricle of the cephalitic and Other Human Serums.—Antibodies to herpes heart. Microscopically there was present a tuberculous arteritis virus were found by Andrewes and Carmicbael in the serum which is suggested as a factor in the wide extent of the lesion. of 72 per cent of twenty-five patients with postencephalitic in Multiple Malignant Neoplasms.—Three cases which parkinsonism and in 75 per cent of twenty-eight unselected two carcinomas were are independent present described by Orr. controls. These observations, therefore, lend no support to In one a carcinoma the left tonsil and of of the tongue, of the the view that the virus of herpes simplex is the essential cause were a the stomach associated. In the second case carcinoma of of epidemic encephalitis. Seven subjects with frequently recur¬ rectum and of the stomach were found. In the third case a ring labial herpes all had antibodies in their serum. carcinoma of the breast and of the colon were associated. Improved Method of Ligating External Carotid Fatal Granulomatosis of Central Nervous System Due Artery.—The preliminary stages of the operation done by case and in a to Yeast.—A is recorded by Smith Crawford, Patterson are the same as those described in the textbooks. of fatal infection of the brain woman, granulomatous and spinal The carotid sheath is exposed and incised over the internal cord a 'fonila by yeastlike micro-organism, probably histolytica. jugular vein, which is freed from its fasciai covering for a Inheritance of Blood Group Factors.—Kinvan-Taylor length of from 2 to 3 inches in the neighborhood corresponding prescnts data in support of the conclusion that no child can to the region of the carotid bifurcation. The vein is now possess in its blood (Lattes 1929) an agglutinarle substance carefully separated from underlying structures, including the which is not present in one of the parents. The possible medico- nerve. It is then retracted toward the mesial plane, legal applications are obvious. instead of laterally as in the classic operation, until the bifur¬ Spinal Métastases of Cerebral Glioma of Type Known cation of the common carotid conies into view. The hypo- as Astrocytoma Fibrillare.—The case described by Russell glossal nerve tends to be retracted forward with the vein and and Cairns is one of astrocytoma fibrillare of the right optic may never· come into sight ; of course, care must be taken to thalamus. The tumor did not give rise to any serious symp¬ avoid injuring this nerve or its branch, the descendens hypo- toms until four months before death, when hydrocephalus set giossi. The actual ligation of the external carotid is carried in and advanced rapidly. This hydrocephalus was due to out at the site of election by adopting the same technic as obstruction of the aqueduct of Sylvius. The tumor was firm in the classic procedure. Sometimes it may be advisable to and in its edge were numerous calcified areas which in life had tie the ascending pharyngeal artery. In uncomplicated cases revealed the outline of the tumor in roentgen films. On Insto- this method is said to be simpler than the older one.

Downloaded From: http://jama.jamanetwork.com/ by a University of Arizona Health Sciences Library User on 05/29/2015 Bulletins et Mém. de la Soc. des de Paris the other was in a man who took 4.8 Gm. and succumbed after Chirurgiens of 32:37-104 (Jan. 24-Feb. 7) 1930. Partial Index having presented dyspnea a Cheyne-Stokes type and cyanosis. Venesection and stomach to of '"Partial Amputatimi of Breast for F.pitiielioma. 1. II. Rubcns-Duval ; lavage of the led the recovery II. Dartigues; III. G. Luquet; IV. J. Lanos and V. G. Léo.—p. 45. the first patient. Necropsy in the other showed that barbital Coxa Vara. R 65. derivatives had been transformed to hydrocyanic acid, probably Vesiculography. Le Fur.—p. 70. as a result of putrefaction. The authors point to the toxico¬ Partial Amputation of Breast for Epithelioma.—Rubcns- logie importance of these observations and discuss the methods Duval states that the practice of systematic, surgical removal of treatment of such poisonings. of the whole breast with cleaning out of the axilla is based (54): 283-306 (March 3) 1930 only on statistics which show that the more tissue one removes, the more chances one has of passing beyond the limits of the •Acute Leukemia with Mediastinal Tumor. P. Émile-Weil, Isch-Wall and 287. cancer. fail to whether or not this Bertrand.—p. Statistics, however, prove Tuberculous Rheumatism of Artbralgic Type with Recurrent Symptoms total removal is the best treatment for all cases. Some rela¬ of Periosteal Involvement. Guy-Laroche.—p. 293. tively benign varieties of cancer of the- breast may be cured Relation BettMeen (hickenpox and Herpes Zoster. F. Masselot.—p. 294. Cutaneous Krumioii ami Infectious Endocarditis. II. Esclibach. by amputation. Dartigues reports the ease of a woman, Prolonged partial —p. 297. aged 65, on whom he performed a partial mammectomy for Radicular Syndrome After Spinal Anesthesia. C. I. Urechia and L. microscopie examination, and cancer was found. The patient Drageaiir.—p. 300. Hernia of Form Without Previous refused a second, radical At the present seven Diaphragmatic Stomach: Medicai operation. time, Traumatism. P. Latra and M. 302. months after the first operation, what remains of the breast Gauch.—p. clinically healthy and there is no involvement of the Acute Leukemia with Mediastinal Tumor.—Émile-Weil lymph nodes. Luquet presents observations of two patients et al. conclude that írom a hématologie point of view the case from whom he removed a small breast tumor, which on micro¬ that they report was one of an acute, authentic leukemia, but scopic examination was found to be an epithelioma. One of clinic-ally there appeared some peculiarities, as the presence of the patients refused a complementary operation and in the last a large mediastinal tumor, the absence of an infectious syn¬ twenty-six months has not shown signs of recurrence of llie drome, and the absence of hemorrhage. These peculiarities are tumor. The second one submitted to a radical removal of the characteristic of chloroma and differ only in the localization breast and a cleaning out of the axilla. An examination of of the tumors. The absence of a green color fails to change the excised tissue showed no evidence of cancer, cither in the the diagnosis of chloroma, for more important than color are breas?! or in the lymph nodes, although symptoms were clini¬ the microscopic study of the tumors and their clinical similarity. cally The author concludes that all tumors of the perceptible. (54): 355-380 (March 17) 1930 breast, even when doubtful in nature, should be treated by •Danger in Injecting Large Doses of Epiiu-phrine. Pasteur Vallery-Radot. an radical operation. Lanos presents instance in which a biopsy P. 355. showed that it was a ease of epithelioma. He performed total Use of rhennlsnlphonplithalcin for Study of Renal Function. A. Goris and Pasteur amputation of the breast with cleaning out of the axilla. Yalk ry-Radot.—p. 357. Late Syndrome of Sclerotici ina with Cataract Due to Endocrine Dis¬ Microscopic examination of the excised tissue revealed no turbances. A. Sézary, A. Faveav and II. Mamou.—p. 358. evidence of and the author concluded that the whole cancer, Danger in Injecting Large Doses of Epinephrine.— cancerous area was removed by the biopsy. Léo, from his Pastear Vallery-Raéet reports a case of complete aphasia due observation of forty-seven breast tumors, prefers an extensive to an overdose of epinephrine. The patient was given three to a limited operation when the clinical and the anatomico- subcutaneous of 0.25 mg., 0.5 and 0.5 on pathologic diagnosis is doubtful. injections mg. mg. three consecutive days. The author asserts that not more than 0.25 mg. of epinephrine should be given at the first de la Méd. des de Paris injection Bull, et Mém. Soc. Hôpitaux except in cases of severe shock, in which 0.5 mg. may be used. (54): 213-2S2 (Feb. 24) 1930 Generalized Achondroplasia with Osteoporosis and Vitíligo: Basal Metab¬ Bulletins et Mém. de la Soc. Nat. de Paris olism in Patients with Achondroplasia. G. Guillain and P. Mollarci. Chirurgie, J14. 56: 197-232 (Feb. 22) 1930 mitai and Hereditary Symmetrical Palmar and Plantar Kerato- Vicious Union of Fracture of Iìoth Malleoli. P. Moirotid.—p. 198. dermia. M. Debray ami .! Sainton.—p. 22t>. •Intestinal Perforation During Typhoid. P. Moiroud.—p. 200. Intolerance and Anaphylaxis. A. Tzandi Biliary Ileus. H. Duboucher.—p. 205. Pseudovisceralgic Form of Chronic Vertebral Rheumatism. A. Lacroix 'Resection of Pylorus in Gastric Perforations Due to Ulcer and Cancer. and K. kaynaud.—p. 236. P. Guibal.—p. 214. Measurement of Cardiac Capacity at Necropsy. C. Lian, M. Kaplan •Total Invagination of Colon. Itiasset.—p. 223. P. Puech.—p. 240. 'Gastric Ulcer Perforated Without Clinical Symptoms. R. Grégoire.— live Unies of Right and Left Ventricle in Etiology of Various p. 225. Types of Cardiac 1 nsutiieieticy. C. I.¡an, P. Puech and R. W'aitz.— Intestinal Perforation During Typhoid.—This occurred Tuberculous Rheumatism nf an Arthralgic Type with Recurrent Symp¬ in a boy, aged 11, who had an unusually severe typhoid infec¬ tom- al [nvohrement. ti. Laroche and IViuneau-ln lille. tion. Operation could not be done by Moiroud until eighteen "Severe Intoxication by Barbital and Formation of Hydrocyanic Arid in hours after the perforation had occurred, when the patient was Blood. E. Knhii-Abrest. I.. Capus, II. I)cs:nll·' and Villard.—p. 261. showing symptoms of generalized peritonitis. When the abdo¬ with Cirrhosis of Liver and (i. hysèal Syndrome Splenomegaly, men was opened, a thick, yellow fluid and a small l'aisseau and V. Oumansky.- p. 267. escaped was found on the convex of :ia f Chronic Polyarthritis by Gold Salts. J. Forestier.—p. 273. perforation part the last loop of the ileum at a distance of about 25 cm. from the cecum. The and Hereditary Symmetrical Palmar and Congenital intestinal loop was exteriorized, a suprapubic incision was made Plantar Keratodermia.—Debray and Sainton observed a ease and a drain was inserted, which was, however, removed after of keratodermia of the palms and soles in a woman, aged 26. forty-eight hours. Fluid was discharged abundantly through There was a considerable thickening of the palms and soles the fistula and the perforation increased gradually. It appeared and a tendency for the involved areas to be moist. The con¬ as if the entire Peyer patch had become necrotic. The patient dition appeared in the patient soon after birth, and was found seemed to improve, but about two weeks later a second perfora¬ to be present in all members· of the family. The patient was tion occurred and during dressing of the wound, which was otherwise normal. exceedingly painful, a hernia of the intestinal mucous membrane Severe Intoxication by Barbital and Formation of took place with enlargement of the perforation. However, Hydrocyanic Acid in the Blood. Kohn-Abrcst et al. about litty days after the operation, the intestine was restored

— observed two ceses of barbital addiction in which hydrocyanic to its normal position. One year and eight months afterward acid was noted in the blood. The first was in a woman who the child was reported in good health and liad resumed his »bed shortly after she had taken 3 Gm. of barbital, and school work.

Downloaded From: http://jama.jamanetwork.com/ by a University of Arizona Health Sciences Library User on 05/29/2015 Resection of Pylorus in Gastric Perforations Due to Paris Médical Ulcer and Cancer.—Guibal stresses the importance of early 1: 221-236 (March 8) 1930 intervention after have occurred. In three gastric perforations •Biologie Diagnosis of Pregnancy. L. Brouha, H. Hinglais and H. of his four patients operation could be done within seven or Simonnet.—p. 221. eight hours, in spite of which one patient subsequently died. In Therapeutic Effect of Extract of Fenugreek (Trigonella). P. M. de 225. the other the operation was done fifty-three hours later, Traverse.—p. patient Treatment of Angina Pectoris with Muscle Extract. J. S. Schwarzmann, as but the result was favorable the perforation had been closed, —p. 226. thus preventing the escape of intestinal contents into the peri¬ Separate Functions of Liver and Bile Tract. M. Chiray and I. Pavel, toneal cavity. He points out that the condition of the stomach —p. 228. Artificial Pneumothorax in Social Hygiene. G. Rosenthal.—p. 232. at the time of perforation is important in the prognosis. In Treatment of Diphtheria Carriers with Oxyquinolin Sulphate. M. Lis¬ the first three patients perforation occurred about four hours bonne, P. Devèze and Labraque-Bordenave.—p. 234. after the and this the minor meal, explained intraperitoneal Biologic Diagnosis of Pregnancy.—Brouha et al. found effusion and lack of food and the fact that the particles peri¬ that the urine of pregnant women contains a hormone after the toneal reaction was moderate and that there was altogether fifteenth day of pregnancy which they consider is produced by no subsequent infection. But in the other patient also there the anterior lobe of the hypophysis. After the third month of was no severe for reaction, for he had been suffering several pregnancy it also contains folliculin. The authors repeated the and not to eat. Likewise the days had therefore been able experiments of Aschheim and Zondek on not fully developed not a severe how¬ patient who succumbed did present reaction; female mice; injection of the urine of pregnant women caused and the ever, fluid escaped in great quantities from the wound rapid development of the genital tract. Two substances appear tentative diagnosis of a pancreatic fistula was made. Although to be active in the same direction ; namely, the hypophyseal he appeared to improve after a second intervention, severe hormone and folliculin. The fact that the urine of menstruat¬ hematcmesis occurred eighteen days later which proved fatal. ing, nonpregnant women likewise contains folliculin leads to Total Invagination of Colon.—Brisset's patient, aged 46, as much as 40 per cent error if the test is applied in doubtful was sent to the clinic with a diagnosis of acute appendicitis. cases. The authors found that if male mice are used, this error However, he liad a normal pulse with only a slight rise in can be avoided. Folliculin does not have a stimulating effect on of temperature, and there was no pain. Next day tenesmus and the genitalia male mice of any weight or age. However, a a bloody stool occurred, and rectally an invagination was injection of the hypophyseal hormone causes marked increase noted. Surgical intervention was done, disclosing double ileo- in the size and weight of the seminal vesicles as compared to was cecal and colocolic invaginations which were fixed by adhe¬ control animals. In 142 women this test performed with sions. Although the patient had tuberculosis, recovery was 100 per cent accuracy. The hypophyseal reaction was par¬ rapid and without complications. ticularly intense in human beings and primates but so far has not been noted in other animals. The reaction on Gastric Ulcer Perforated Without Clinical Symptoms. disappears the third or fourth day after delivery. In all, 650 animals —Grégoire maintains that acute pain is not a sign that per¬ were used by the authors, who state that hypertrophy of the foration of a gastric ulcer has at that moment occurred. It seminal vesicles is simpler to verify than the changes occurring rather a is symptom of peritonitis and follows the actual per¬ in the ovaries of female mice. foration by several hours. His patient, aged 35, had had pain from three to four hours after every meal. Four months later Presse Médicale, Paris but her condition after strict vomiting occurred, improved 38: 145-160 (Feb. 1) 1930 adherence to a later severe hema¬ diet. However, five months Conditions Before Deficiency Diseases Have Become Evident. G. Mouri- tcmesis necessitated hospitalization. There was no further quand.—p. 145. vomiting, but the patient suffered considerable pain, in spite •Experimental Tuberculosis of Lymph Nodes in Guinea-Pigs. G. Paisseau and V. Oumansky.—p. 147. of which she was able to walk to the distant room in which *Severe Eruptive Fever with Myoclonus. V. Audibert and Murat.—p. 149. roentgen examinations were made. Ingestion of the barium Acid-Base Equilibrium of Blood, pu and Alkali Reserve. R. Letulle and compound renewed the pain and roentgen examination dis¬ M. Delaville.—p. 150. the of air in the closed a duodenal ulcer and presence peritoneal Tuberculosis of Nodes in Guinea- later. Experimental Lymph cavity. Surgical intervention was done half an hour and the results obtained in Pigs.—Paisseau Oumansky report they The perforation, from which the barium meal flowed a thin in twenty-five guinea-pigs through inoculation of nonfiltered was on the anterior side of the of stream, proximal portion pathologic substances obtained from five patients who were the duodenum. Posterior transmesocolic gastro-enterostomy suffering from tuberculous ostearthritis, tuberculous abscess and a was laid which was was done and drain removed nine days hemorrhagic pleurisy, respectively, and from one patient in later. Recovery ensued without complications. whom one kidney had been removed for tuberculosis two years previously. The type of tuberculosis which was produced in Journal d'Urologie Médicale et Chirurgicale, Paris the guinea-pigs differed from the lesions observed by other 39: 1-111 (Jan.) 1930 workers, especially Calmette and Valtis, by the presence of Polypi of Pelvis of Kidney. P. Paris.—p. 5. numerous acid-fast bacilli whose reinoculation did not lead to Syphilitic Cystitis. A. Orofino.—p. 25. the of the of lesions these of 31. production original type reported by •Subcutaneous Rupture Kidney. G. S. Epstein.—p. All to Lithiasis with Anuria in Persons with Solitary Kidney. C. Gauthier authors. attempts cultivate these bacilli failed. In three and J. Cibert.—p. 44. of six guinea-pigs, intradermotuberculin tests were positive. Sequestrum in Urethra. B. Pankratiev.—p. 50. The lesions caused by inoculation of material obtained from Irrigation of Seminal Vesicles. H. Blanc.—p. 53. three different patients were examined microscopically ; they Subcutaneous Rupture of the Kidney.—Epstein reports contained epithelioid cells and marked sclerosis throughout the eight cases due to trauma. The author divides subcutaneous tissue. In general, the outstanding characteristics of the experi¬ rupture of the kidney into three clinical groups : serious cases mental tuberculous lesions were the multiple disseminated which necessitate immediate operation, less serious cases, and enlarged nodules which were noted at the site of inoculation those of simple clinical evolution. Invariably the injury can as well as in the abdominal, iliac, lumbar, mesenteric and be diagnosed through hematuria and the formation of a tumor. bronchial lymph nodes. In several animals the adenopathies In severe cases the kidney should be resected immediately, could be palpated in the form of chains of hard nodules reach¬ although it is advisable to perform a function test of the other ing from the site of inoculation in the inguinal region up to kidney before operating or during the operation. A second the umbilicus. It was noted that these tumefactions had dis¬ group causing hematuria and tumefaction is not of immediate appeared spontaneously after the fourth or fifth month in sev¬ danger to life and results in the formation of adhesions. eral animals. Although several animals died, necropsy did not Epstein favors expectant treatment in these cases and operates reveal involvement of the viscera. The experimental tuber¬ only if the symptoms become aggravated. culosis was localized to the lymphatic system and its evolution

Downloaded From: http://jama.jamanetwork.com/ by a University of Arizona Health Sciences Library User on 05/29/2015 was favorable as a rule. The strain of bacilli obtained from researches, repeated many times, have enabled him to identify the lesions was considerably attenuated. The authors compare the pathogenic agent with Cryplococcus hominis. He calls these lesions clinically to the suppurative nodules of scrofula. attention to lesions of this kind, which if allowed to exacerbate Severe Eruptive Fever with Myoclonus.—This unusual and to extend further become, as in this instance, resistant to occurrence is reported by Audibert and Murât. A man, aged all forms of treatment, whereas in the beginning some one might 62, complained of headache and arthralgic pain one evening have proved effective. after having worked in his garden. There was a slight rise Relations Between Serologie Tests and d'Amato Test of temperature and two days later a generalized erythema was in Syphilis.—Pittari concludes from his research that: 1. In noted which was especially marked on his legs and abdomen. the majority of cases, there is a close agreement between the The following week his condition had become worse, he was results of the serologie tests and of the d'Amato test. 2. The asthénie and a marked aversion toward milk became evident. d'Amato test may be particularly useful in certain localizations For several days pain was noted in the precordial region. of syphilis, as in the liver, in which the serologie tests often Hiccups occurred and muscular spasms in the right leg and give negative results. 3. The d'Amato test is useful in suspected clonic symptoms in the facial muscles were noted. The patient cases with a negative serodiagnosis, before treatment is became more and more apathie. The urinary bladder ceased instituted. to function and fifteen days after the onset of the disease death Reactivation of Malaria with Tuberculin.—Cacciapuoti ensued. Although the condition is usually benign, the authors used tuberculin for the reactivation of latent malaria, obtaining to point the importance of a reserved prognosis and direct excellent results. An injection of from 0.75 to 1 mg. of tuber¬ attention to the possible relation of the disease to certain other culin in a phenolized solution induced in about forty-eight hours in and endemic fevers noted Japan Tunis (North Africa) and a typical attack. The author therefore recommends its use, to Rocky Mountain spotted fever. particularly in all instances in which it is necessary to discover 38:265-280 (Feb. 22) 1930 malaria carriers for the sake of the community in general. Old Men. Kidneys of Pasteur Vallery-Radot and P. Delafontaine.—p. 265. 40: 277-316 (Feb. 24) 1930 •McClurc-AUlrich Test in Phlegmasia Alba Dolens. J. Louvel and M. Tisserand.—p. 268. So-Called Pseudoleukemia : Case. A. Ferrata and A. Fieschi.—p. 279. Origin of Cleft Palate. E. Cadenat.—p. 270. Syphilis of Stomach. P. G. Castellino.—p. 282. Right Strangulated and Suppurative Crural Appendicocele: Case. Finiteci McClure-Aldrich Test in Phlegmasia Alba Dolens.— Valerio.—p. 284. "Mechanism of Intestinal Hemorrhage in W. Mikulowski.— Applying the McClure-Aldrich test in five with symp¬ Typhoid. patients p. 289. toms of phlegmasia alba dolens, Louvel and Tisserand found that two distinct types of edema may be distinguished. In Mechanism of Intestinal Hemorrhage in Typhoid.— the paraphlebitic hydrophilous type, mobilization is contra- Mikulowski reports three cases of typhoid in children, in which indicated. However, even marked edema does not contra¬ he observed gastric, intestinal and subcutaneous hemorrhages, indícate treatment by physical therapy if it is anhydrophilous with a "thrombopenic" hemorrhagic syndrome, in the first week and is coincident with phlegmasia alba dolens that has been of the disease. This fact, he says, proves that there is a relation apyretic for about three weeks. The test should be repeated between blood disorders and the appearance of early intestinal several days after recovery, because it may announce a recur¬ hemorrhages. An early intestinal hemorrhage during typhoid is evidence of a a rence of the process. The McClure-Aldrich test gives support hemorrhagic diathesis, provoked in transitory to the theory that the physiopathology of edema is not entirely manner by the typhoid infection. By analogy, one may logically on a mechanical basis but that there is considerable involvement conclude that the ordinary intestinal hemorrhages arising between of the tissues. the seventeenth and the twenty-first day of the disease are • due, for the most part, to the same mechanism. The idea of Schweizerische medizinische Wochenschrift, Basel a hemorrhagic syndrome during typhoid is of practical impor¬ 60:261-284 (March 22) 1930 tance, because it will encourage physicians to examine systema¬ Noma of Cheek. J. Friedmann.—p. 261. tically the physical properties of the blood of every patient with Monocytic Angina. A. Ott.—p. 263. at the of the in order to in Man. H. typhoid beginning disease, apply suit¬ Bruceila Abortus [nfection Custer.—p. 264. the *Ascariasis and Pleura] Empyema. E. Jenny.—p. 266. able treatment that will mitigate hemorrhagic diathesis and Apparent Horizontal Halving of Vertebrae in Roentgenogram: Probable prevent the appearance of profuse and often fatal hemorrhages. of This Phenomenon. E. 267. Cause Baumann.—p. The therapeutic methods should act on the Gastric Secretion and Acid-Base Equilibrium. P. H. Rossier and P. mainly coagulability Mercier.—p. 267. of the blood and not so much on vasoconstriction. Endemic of Inflammation of Throat Probably Caused by Impure Milk. P. Meyjes.—p. 272. Revista Médica de Barcelona Ascariasis and Pleural Empyema.—Jenny reports the 13:1-96 (Jan.) 1930. Partial Index Factor in Essential M. Badia case of a boy, aged 16 months, who had ascariasis. A suppura¬ "Hereditary Hypertonia. Brandia.—p. 3. tive pleural effusion which contained eggs of ascarides developed Hereditary Factor in Essential Hypertonia.—From a In the on the right side. course of three months the boy review of the literature and from his own observations, Badia recovered completely. The development may be explained as Brandia reaches the following conclusions : Essential hypertonia : of follows By way the choledochus, ascarides entered the is observed in 65 per cent of cases of high blood pressure. The liver. On the surface of the liver they caused an abscess, which cardinal characteristic of the condition is its hereditary and perforated through the diaphragm into the pleural cavity. familial nature. It behaves as the typical predominant factor in the strictest mendelian sense, and it is transmitted with great Riforma Medica, Naples regularity. This hereditary morbid predisposition makes all 46: 237-276 (Feb. 17) 1930 the other external and constitutional factors secondary, and it Peculiar Syndromes and Modes of Intervention in Appendicitis. D. represents the union of several factors derived from Giordano.—p. 239. complex •Cutaneous Saccharomycosis with Multiple Localization: Case. M. Pazienza. the sympathetic nervous system, the endocrine glands, and so 244. on. Other characteristics of less importance are its late appear¬ Tests and the d'Amato Test in «Relations. Between Serologie Syphilis. E. ance (at about the age of 40), its slow evolution (about twenty Pittari.—p. 251. its association with the con¬ •Reactivation of Malaria with Tuberculin. G. Cacciapuoti.—p. 255. years' duration), megalosplanchnic Peculiarities of Cardiogram Characteristic of Narrow Chest. G. Castelli. stitution and its fatal end. Death occurs by either apoplexy —p. 257. or heart failure. In the cases in which hypertension is of a Painful Atrophy of Fingers, or Ledderhose-Secrétan Syndrome? F. renal death is caused whereas 257. origin, by uremia, in essential Bellelli—p. hypertonia it is caused by heart failure. A megalosplanchnic Cutaneous Saccharomycosis with Multiple Localiza¬ constitution is a coadjuvant factor. In patients of this type, tion.—Pazienza shows how difficult the diagnosis is and how hypertonia appears at an earlier age and death occurs sooner easy it is to confound a mycotic granuloma with other lesions, than in patients not of this type. The fact that these persons especially neoplastic lesions. Bactériologie and histologie have a low blood pressure before 40 years does not exclude the

Downloaded From: http://jama.jamanetwork.com/ by a University of Arizona Health Sciences Library User on 05/29/2015 probability that hypertonia may develop later. Because of the formed early and should include removal of all diseased tissue late appearance of the condition and its slow evolution, persone (not only the central part of the carbuncle but also of those with hypertension, as a rule, reach the limit of the normal parts to which the subcutaneous cellulitis has spread). length of life. The prognosis is good, though some factors (such as the condition of the heart, of the kidneys and of the Archiv für Gynäkologie, Berlin vessels) may have a bad influence. Among the factors which 140: 1-2S4 (.March 01 1930 should also be considered in the prognosis are the constitution, *.\nimonia Content of Blood During Pregnancy, A. Hock.—p. 1. previous illnesses, the cause of the last illness, and the age at Resistance of Erythrocytes to Bile Salts During Pregnancy. II. Eufinger, H. Wiesbader and I.. 21. which the parents of the patient died. Hypertonia and con¬ Focsaneanu.—p. Mechanism of Labor Without Pressure of Spinal Column of Fetus. stitution are two factors which may be inherited individually W. Lüttge.—p. 27. or in association with each other. When inherited in associa¬ Metabolism in Puerperal Sepsis. N. Louros and E. Gaessler.—p. 43. tion, it is that the will die at about the same Statistics on Cesarean Section for Years 1915-1928. E. von Aminoli. probable patient 66. age at which the (from whom he inherited these —p. parent factors) Intracranial Pressure in Fetus and Changes Produced in It by Applica¬ in case is An died. Heredity this homochronous. obese, hyper¬ tion of Forceps. E. Gurcwitsrh and J. Vögel, p. 123. tensive megalosplanchnic patient (whose parents were thin) will 'Diagnosis of Pregnancy: A Simple Serum Reaction. F. Matioilo'l. die younger than his parents did. On the contrary, the thin p. 138. Causes of Onset of Labor. II. Rossenbeck.—p. 141. hypertensive patient (whose parents were megalosplanchnic) Corpus I.uteuni: Physiology. II. Knaus.—p. 181. will live longer. Oxidation Quotient of Urine During .Menstruation. H. I.ewin.—p. 191. *Cholesterol Content of Blood in Cancer. II. Guthmann.—p. 202. Semana Médica, Buenos Aires ^Artificial Vagina Formed from Sigmoid. B. Frankenberg.—p. 226. Sai eeiiia of Great Oiueiitum. A. Mandelstamm.—p. 253. 37: 513-576 (Feb. 27) 1930 •Medical Treatment of Pulmonary Abscess. G. Peco and F. E. Secco.— Ammonia Content of Blood During Pregnancy.—Rock 513. p. states that despite the faci that the blood ammonia plays a 1 lydrarthrosis: Late Serum Reaction After Administration of Anti- rôle in anthrax Serum. I. Natin.—p. 523. maintaining the actual neutrality of the blood during •Causes of Death from Carbuncle in Diabetic Patients. R. Rodriguez pregnancy, its amount has heretofore not been determined. In Villegas.—p. 527. examinations of the blood of 120 pregnant women, he found Technics Results of Test: and Dick Advisability of Standardization of that whereas the amount of ammonia in Dose. E. A. Molinelli.—p. 529. preformed nonpregnaiit women is 0.293 hundred the Early Diagnosis and Treatment of Typhoid. A. A. Salutoni, -p. 541. nig. per cubic centimeters, during Tuberculosis in Early Childhood. G. A. Schiavone.—p. 543. first half of pregnancy it is increased to 0.314 nig. and during Uremia. H. Annes Dias.—p. 562. the last half to 0.401 mg. During labor the amount for the Bacteriolysis and Bacteriotherapy : Effects of Provoked or Normal Organ first stage is about the same as for the last half of ferments on Tubercle Bacillus. J. \Y. Howard.—p. 57L pregnancy, but during the second stage it reaches its maximum value of Treatment and Medical of Pulmonary Abscess.—Peco 0.501 mg. On the fifth day of the puerperium the normal value Secco consider as important points for the treatment of pul¬ is not yet reached (average value of 0.347 nig.). In all of monary abscess the previous determination of its localization, eight cases of toxicosis of pregnancy the amount was increased evolution and nature. extension, During the acute period, they (average value of 0.648 mg.). In cases of eclampsia the amount advise medical treatment to promote the natural drainage oí was not greater than in other forms of toxicosis. the abscess. subcutaneous of emetine Daily injections hydro¬ of A Serum chloride should be resorted to first. The dose should be from Diagnosis Pregnancy: Simple Reaction. —Manoiloff describes a serum reaction for in 0.006 to 0.008 Gm. (divided into two doses of from 0.00.5 to pregnancy which he uses the a 2 cent 0.004 Gm.) each day for ten days. If after that period improve¬ following reagents: (1) per aciueous solution of theobromine sodiosalicylat* in which the latter is ment is not manifested, the authors advise the use of specific and a serotherapy with subcutaneous injections of antigangrenous completely dissolved, (2) 0.2 per cent filtered alcoholic solution of nile blue. The glass vessels must be clean serum in cases of putrid and fetid abscesses, and autistreptococcic perfectly and of the same size. To 5 of indicated fresh serum in cases of simple abscesses in which the streptococcus drops serum, which must be clear and transparent, 1 cc. of the first is the predominant organism. Third in importance is the treat¬ reagent is added and the mixture is shaken; 1 second ment with autolysates made from the expectorations of the drop of the reagent is then added and the mixture is patient. The treatment with arsenical drugs is particularly again shaken vigor¬ ously. After an interval of from a few minutes indicated in the presence of a putrid abscess in which spiro- to one hour, the result is read. If the serum examined is a chetes are the predominant organisms, and of abscesses of from nonpreg¬ nant woman, the solution remains or amebic origin. If the patient does not improve, surgery is blue becomes bluish or If is a indicated to effect easy evacuation of the pus. In a group of bluish rose. it from pregnant woman, it is decolorized and or six cases treated by the authors, good results were obtained with appears yellowish rose yellowish. The author states that he has obtained correct results with this 94 emetine hydrochloride in three cases (one of the patients also reaction in per cent of 696 serums that he tested. received subcutaneous injections of autistreptococcic serum and later autolysates) ; from serotherapy alone in two cases, and Cholesterol Content of Blood in Cancer.—In determina¬ from autolysates in one case. The treatment with arsenical tions of the cholesterol content of the blood in 229 cases of preparations was coadjuvant treatment in some of the cases. cancer, Guthmann found that even in persons with early car¬ Causes of Death from Carbuncle in Diabetic Patients. cinoma the amount is decreased. In late carcinomatous processes the cholesterol content of the blood is —Rodríguez Villegas says that a carbuncle, when treated early, markedly decreased. In cancer there is a direct relation between the clinical has a good prognosis (even in patients with grave diabetes). course of the condition and the cholesterol content of The most serious and frequent complications of diabetes are the blood. either carbuncle or gangrene of the legs. Such cases con¬ Artificial Vagina Formed from Sigmoid.—Frankenberg stitute a serious medical and surgical problem. The carbuncle gives an illustrated description of a method of forming an should be extirpated as if it were a malignant tumor. The artificial vagina in which he uses -a segment of the sigmoid. author says that the most frequent cause of death is septicemia The advantages of this method are that the blood supply of (40 per cent). Of five patients whom the author observed in ninent of sigmoid is not interfered with as much as is the two Argentinian institutions, two died from septicemia, one blood supply of the loop of small intestine used in the Baldwin from shock six hours after operation, and one from broncho- operation ; the ease with which the sigmoid is sutured to the pneumonia ; in one the cause of death is not stated. All these introitus vaginae ; the small amount of mucus secreted by the patients entered late (about fourteen or twenty days after the sigmoid as compared with the amount secreted by the small onset of the complications) and were in a condition either of intestine; the absence of a tendency to the formation of a septate precoma or of grave toxemia. Strict personal hygiene, diet vagina, and the greater distensibility of the sigmoid. In four and insulin therapy applied early are the principal factors to of five cases in which he used this method the author obtained secure success from the treatment. Operation should be per- good results.

Downloaded From: http://jama.jamanetwork.com/ by a University of Arizona Health Sciences Library User on 05/29/2015 Deutsche medizinische Wochenschrift, Berlin deprivation of chlorine, abundance of vitamins and mineral salts, 56:465-510 (March 21) 1930 limitation of carbohydrates and of proteins, and generous supplies Diagnosis and Treatment in Fractures of Patella. C. Goebel.—p. 465. of butter. The combined effects of all these components guaran¬ Treatment of Insomnia. H. Molitor.—pu 468. C'en. tee the good results of this constitutional therapy. •Therapeutic Value of Extracts from Parathyroids. K. Hajos.—p. 471. Prophylaxis and Treatment of Mastitis. R. Brühl.—p. 473. •Funicular Myelosis in Pernicious Anemia. H. Pinéas.—p. 476. Klinische Wochenschrift, Berlin •Cod Liver Oil with Elementary Plinsphnrus an Essential Factor in 9: «J3-4Í0 (March 8) 1930 of M. Gerson-Herrmannsdorfer's Dietary Treatment Tuberculosis. So-Called Mitogenetic Rays (Gurw itsch ). F. Wassermann.—p. 433. Gerson.—p. 478. Statistical Studies on Lefthandedness and Its Variations. B. Kamm.— to Article. A. P. 4SÛ. Reply Preceding Bacmcister and Rehfeldt.—p. p. 435. Value of Extracts from *Uric Acid Content of Blood and Acidosis: Their Significance for Prog¬ Therapeutic Parathyroids.— nosis of Chronic Diseases of \V. 440. the Kidneys. Singer.—p. In experiments with extracts from parathyroids, Hajós Determination of Quantity of Blood in Children. H. Seckel.—p. 111. discovered some new therapeutic applications. Parathyroid Clinical Aspects and Diagnosis of Subacute Epidemic Encephalitis. F. G. therapy brings good results not only in tetany and spasmophilia von Stoekert.—p. 445. Advisability of Tests for Syphilis on All but also in such conditions as clinical Performing Serologie Hospital idiosyncrasy, anaphylaxis Patients. G. Zimmermann.— p. 448. and the so-called allergic disturbances. This therapeutic effect Syphilis Reaction in Patients with Diphtheria. V. Niederwieser.—p. 450. cannot as due to the increased cal¬ be-explained being entirely Uric Acid Content of Blood and Acidosis: Their cium content of the blood. A of the large percentage patients for of Chronic Diseases of had previously been treated with calcium preparations, but with¬ Significance Prognosis Kidneys.—Observations on patients with diseases of the kidneys out result, whereas a combination of oral calcium with therapy convinced Singer that the determination of the uric acid content injections of hormonal extract from the parathyroids led to of the blood and the detection of the alkali reserve are of equal or at least to The author thinks that recovery improvement. significance in the prognosis of severe renal insufficiency. The besides the prolonged calcium effect on the sympathetic system two methods supplement each other. In exceptional eases the the have still another as not parathyroids function, yet one is superior to the other. It is therefore advisable always understood but of a favorable thoroughly capable exerting to perform both tests. influence on the disturbed sympathetic equilibrium. Careful observations in patients with nephritis or nephrosis convinced 9:481-528 (March 15) 1930 the author that in the treatment of these conditions parathyroid Present Status of Knowledge Concerning Male Sex Hormone. S. I.oewe and H. E. 481. are of no value. He found that the extract Voss.—p. preparations special Cholecystography and Function of Liver. R. Bauer and U. Strasser.— inlltienced neither the diuresis nor the blood pressure. It appears p. 487. that if the rest nitrogen is only slightly increased, parathyroid *Mcatless Diet for Treatment of Ménière's Disease. O. Muck.—p. 491. extract is helpful. However, if considerable amounts of nitrogen Hormone of Ovary and of Placenta of Greater Therapeutic Value Than Hormone of Anterior Lobe of Hypophysis. O. O. Fellner.—p. 494. are retained, the is ineffective. Other disorders in preparation Clinical Experimental Studies on Poisonous Effects of Tribromethanol which parathyroid extract might be of therapeutic value are on Liver. P. Kacpiander.—p. 495. the hemorrhagic diathesis and chronic hemorrhages. The *Tests of Metabolism in Patients with Exophthalmic Goiter: Self- Regulation of Diseased F. Boenheim.—p. 497. author's in such cases were limited, so that he Organism. experiences Examination of Cerebrospinal Fluiti with Flocculation and Wassermann cannot make definite statements. However, he wishes to direct Tesis. II. Sachs anil E. Witebsky.—p. 499. attention to this question, and he advises that in cases in which New Micromcthod for Quantitative Determination of Sugar in Crine. E. Pros.—p. 501. a prolonged calcium treatment is indicated, the oral administra¬ tion of calcium should be combined with injections of extract Meatless Diet for Treatment of Ménière's Disease.— from the parathyroids. Muck peints out that the vasoconstrictor nasal reflex, the phe¬ Funicular Myelosis in Pernicious Anemia.—According nomenon of mucograp'ina alba, which is produced by the to Pinéas, the correlation between funicular myelosis and cpincphrine probe test, always indicates a disturbance in the pernicious anemia is as yet not entirely clear. He studied fifteen cephalic vascular innervation. This reflex can be produced in cases, and five of them he describes in detail. In the majority epilepsy, in migraine and also in Ménière's disease. The fact of cases the characteristic symptoms of pernicious anemia had that the reflex can be produced in Ménière's disease proves that been manifest several years before the nervous disorders. In this disorder is caused by angiospastic conditions in the auditory four instances, however, the disease commenced with motor and artery. Karger has proved that epilepsy in children can be sensory disturbances, and the symptoms of pernicious anemia counteracted by a meatless diet. Accordingly the author >cd later. The author states that in patients with spinal subjected patients who had frequent attacks of migraine, a dis¬ symptoms, even if there are no indications of anemia, the blood turbance to which he applies the term hemicrania sympathico- picture should be studied and other signs of anemia should be tonica, to a meatless diet. He obtained good results ; either the watched for, such as paresthesia of the tongue, achylia and attacks ceased entirely or they became less frequent and less yellow discoloration of the serum. He thinks that if this is severe. These observations induced the author to employ the done, anemia may be discovered in many cases of funicular meatless diet also in the treatment of patients with frequent myelosis. He also thinks that early liver therapy of anemia attacks of Ménière's disease. He gives a detailed report of five will prevent an exacerbation of the nervous symptoms. He cases. That this method was successful was proved not only by recommends that large doses of liver be given for longer periods, the outcome of the epinephrine probe test but also by the and if this is done, the liver treatment will also influence the patients' own observations. They found that the meatless diet spinal .symptoms, and the failures will not be as numerous as had influenced their condition favorably, and they were willing some authors are inclined to believe. to continue the diet. The author emphasizes that the treatment can be successful in those who to Cod Liver Oil with Phosphorus an Essential Factor in only patients adhere strictly Gerson-Herrmannsdorfer's Dietary Treatment of Tuber¬ the regimen. culosis.—Referring to an article by Bacmeistcr and Rehfeldt, Tests of Metabolism in Patients with Exophthalmic who stated that cod liver oil with elementary phosphorus was Goiter: Self-Regulation of Diseased Organism.—Boenheim not an essential factor in Gerson-Herrmannsdorfer's dietary determined the basal metabolic rate in forty-six patients with treatment, and when given in large doses would even be harmful, exophthalmic goiter. He found that in thirty -seven persone Gerson stresses the significance of cod liver oil. He comes to the basal metabolism was increased, in six it was normal and the conclusion that it is difficult to determine the therapeutic in three it was reduced. In order to show that in the latter value of each factor of the treatment.' Patients wdth dissimilar three cases the diagnosis of exophthalmic goiter was correct, constitutions react differently to the treatment as a whole as the author describes two of them. In these patients the con¬ well as to the component factors. Therefore it was advisable dition of the basal metabolism and of the specific dynamic action to find a treatment suitable for the average person. The nature indicates a sort of self-regulation on the part of the disi and effect of the dietary treatment are closely connected with organism. As yet it has not been determined what causes this

Downloaded From: http://jama.jamanetwork.com/ by a University of Arizona Health Sciences Library User on 05/29/2015 self-regulation nor why it does not become effective in all The author does not give more than 1.6 Gm. in the course of instances. The author determined the basal metabolic rate and twenty-four hours. After the first difficulties are overcome, the specific dynamic action also in ten patients with myxedema. each case requires individual treatment. The process of birth In one patient the metabolic rate was normal, in all the others should be hastened. In some instances cesarean section is it was reduced. It was also noted that the specific dynamic necessary. After each eclamptic attack, both before birth and action usually is inversely proportional to the basal metabolic during the puerperium, the administration of oxygen is advisable. rate ; that is, the lower the basal metabolism, the higher the Following delivery, rectal drip infusions of 1 liter of a 5 per specific dynamic action. cent sugar solution are helpful. Cause of Heartburn.—According to Bartlakowski, it is Medizinische Klinik, Berlin generally assumed that the hydrochloric acid content of the 26:375-412 (March 1930 14) stomach is the cause of heartburn. As a result of an anomaly Rheumatic Infection During Childhood. B. Leichtentritt.—p. 375. in the of the cardiac the acid For and Against Adlers Individual Psychology. E. Flusser.—p. 378 motility sphincter, hydrochloric •Tannic Acid in Diagnosis and Treatment of Gastric and Duodenal Ulcers finds its way from the stomach into the esophagus. This theory H. Rosencrantz.—p. 381. was investigated by several authors and some of them arrived •Prevention and Treatment of Eclampsia: Observations in 111 Cases. at different theories the 1'. 383. concerning pathogenesis. Being subject Rissmann.—p. to Speedy and Active Refilling of Vascular System After Profuse Hemor frequent attacks of heartburn, the author studied thjs problem rhages by Means of Injection of Dextrose Solution. E. Simenauer on himself. He observed that whereas some patients describe —p. 385. heartburn as a burning sensation passing from the stomach •Cause of Heartburn. J. Bartlakowski.—p. 388. Vaccine Therapy in Brucella Abortus Infection. H. J. Lang.—p. 389 upward, others, including himself, feel the burning pain mainly Ilallux Rigidus: Its Nature, Relation to Trauma and Treatment. Floss in the pharynx. He is free from the sour eructation and vomit¬ bach.—p. 389. ing which in some persons occur with heartburn. The various Blood Sugar Curve as Indicator of Fitness for Athletic Activities. F. Deutsch and E. Weiss.—p. 391. antacid remedies, especially those that are given in tablet form Estimation of Heat Effect in Diathermy Treatment. E. Freund and and dissolve only in the stomach, were not effective in his case. F. Benz.—p. 392. However, if he dilutes sodium bicarbonate or a magnesium Tannic Acid in Diagnosis and Treatment of Gastric preparation and drinks it slowly, the heartburn disappears at and Duodenal Ulcers.—Rosencrantz discovered in the tannic once. Accordingly, he reasons that in his case the heartburn acid test a method that is valuable not only for the diagnosis must be caused by anatomic conditions in the esophagus. It but also for the treatment of gastric and duodenal ulcers. If has been found that in many persons islands of gastric mucous the reaction is positive, that is, if the pain ceases shortly after membrane, which have the same secretory capacity as the mucous the administration of 0.1 or 0.2 Gm. of tannic acid, an ulcer is membrane of the stomach, are found in the esophagus. The size present. In case of a negative reaction, with the pain persisting of these islands varies. They may be found in about 70 per or diminishing only slightly, roentgen examination is indicated. cent of all human beings. The author found them in six out If roentgenoscopy gives negative results in cases with persistent of ten cases. He thinks that these producers of hydrochloric pain, an ulcer is not present. If, however, the pain is slightly acid, besides other causes, are doubtless an etiologic factor of diminished and the roentgen examination does not indicate an heartburn, especially in those instances in which the heartburn ulcération, then it is probable that an ulcer exists and other is localized in the region of the pharynx. diagnostic methods should be resorted to. The author thinks that the tannic acid test, combined with careful observation of Monatsschrift f. Geburtshülfe u. Gynäkologie, Berlin the clinical aspects, especially if the reaction is positive, is the 84:241-318 (March) 1930 most of all the methods that are in comprehensive employed •Incidence of Relative Lymphocytosis in Women During Menopause. the diagnosis of gastric ulcers. Concerning the therapeutic J. Sakheim and H. Lehfeldt.—p. 241. Tolerance of Uterus value of tannic acid, the author states that complete cure has Duplex Gravidus in Repeated Curettage of Non- been obtained in and gravid Half. S. Itzkin.—p. 249. simple gastric duodenal ulcers ; good Multiple A. have in •Puerperium Following Pregnancy. N. Gidalewitseh.—p. 261. effects been noted gastritis and in complicated gastric "Ultraviolet Irradiation of Mammary Glands. H. Küstner and R. Borner. and duodenal ulcers ; that is, in ulcérations with large niche —p. 275. Gastroschisis in the New-Born. B. 281. formations, with involvement of the serous coat of the stomach, Kleiner.—p. Centers for Collecting and Mother's Milk. M. E. rest the or other such as Dispensing Kayser. of the of peritoneum of organs, the —p. 293. gallbladder and the pancreas. The tannic acid was given in Incidence of Relative the form of tablets containing 0.25 Gm. of tannic acid every Lymphocytosis in Women Dur¬ the basis two hours during the day, that is, from six to eight doses. ing Menopause.—On of their observations in fifty- one women in the Sakheim and No other treatment was given. In patients with cancer of the menopause, Lehfeldt state that in a of climacteric women a stomach, of the colon or of the rectum, the administration of large percentage there is relative believe that the tannic acid resulted in a decrease in the hemoglobin content. lymphocytosis. They lymphocytosis is caused a In of their In all these patients the cancerous growths were in an advanced by thyrotoxicosis. support theory they call attention to the with which and variable blood stage. The tannic acid effected a diminution of the pain and frequency high the patients felt comparatively well. However, pressures are found in women during the menopause and the they gradually results of became more cachectic and died. good detoxicating and sedative methods of treatment. Prevention and Treatment of Eclampsia: Observations Puerperium Following Multiple Pregnancy.—In a study in One Hundred and Eleven Cases.—Rissmann found that of the clinical histories of 574 cases of multiple pregnancy, Gidalewitseh found that in the wrong and excessive nutrition of the pregnant woman is an puerperium following multiple pregnancy occurred much more essential factor in the development of eclampsia. He recom¬ complications frequently than do in the mends a largely vegetarian diet and forbids the use of strong they puerperium following single pregnancy. The incidence of febele diseases was spices and alcoholic drinks. It has been noted that in pregnant three times as great, increases in temperature above 38 C. noted in women the albumin of eggs, when eaten raw, passes more readily (100.4 F.) being 32.8 per cent of the cases. The into the blood and urine than in other persons. Raw eggs are mortality following multiple pregnancy therefore not advisable and strong cheeses should likewise be was ten times as high as the mortality following single avoided: In case of disturbances in the metabolism the author pregnancy. recommends, besides the special diet, the administration of Ultraviolet Irradiation of Mammary Glands.—Küstner medicaments, especially of vitamins and hormones. As the main and Borner used ultraviolet irradiations of the mammary glands factors in the therapy of eclampsia the author stresses starva¬ in twenty-one lactating women to increase the flow of milk. tion, venesection (the amount of blood withdrawn should be Contrary to the observations of several other investigators, about 500 cc.) and repeated intramuscular injections of phéno¬ they did not note an increase in the flow of milk sufficiently barbital, 0.4 Gm. into the chest or arm every two, four or six marked and sufficiently constant to permit them to ascribe to hours, determined by the frequency of the eclamptic attacks. the irradiations a galactagogue action.

Downloaded From: http://jama.jamanetwork.com/ by a University of Arizona Health Sciences Library User on 05/29/2015 Monatsschrift für Kinderheilkunde, Leipzig tities. It has also been found that in acute nephritis a retention 46: 193-288 (March) 1930 of urinary pigment in the blood, especially of urochromogen, Kala Azar: First Case Observed in Palestine. . Ostrowski.—p. 193. does not become manifest. The specific gravity of the urine Intrapulmonary and Extrapuhnonary Cavities in Children: Roentgen may be increased, but it retains its color, because the conversion Diagnosis. . Kleinschmidt.—p. 205. of chromogens into pigments is not disturbed. However, in •Feer's Neurosis. M. Frank and E. 221. Sympathetic Podvinec.—p. renal of with contracted the con¬ •Hypermineralization Following Intensive Antirachitic Treatment. 11. insufficiency patients kidney Opitz.—p. 228. ditions are reversed. In the blood the aromatic intestinal Neuromuscular Irritability in Infants. A. Peiper.—p. 237. putrefaction products are found earlier and in larger quantities. Racemose Livedo: Case. P. Frick.—p. 257. Occasionally, but not frequently, they are already increased at Pyodermia in Treatment. K. 260. Nurslings: Ochsenius.—p. a time when the urea content of the blood is still normal. In Feer's Sympathetic Neurosis: Bladder Disturbances.— the serum a number of chromogens, as urorrhodinogen and Frank and Podvinec report a case of Feer's sympathetic urochromogen, may be demonstrated. The urine is lighter in neurosis in an infant, aged 3 months. In addition to the color, and its specific gravity is about 1.010. It contains numer¬ characteristic symptoms of this disease there was present a ous chromogens ; however, their conversion into coloring matter disturbance in the functioning of the urinary bladder. For is disturbed. Recent investigations indicated that in muscular three days the child did not void any urine spontaneously. By activity the uric acid formation is increased. It is probable that means of pressure on the abdomen and catheterization, how¬ the cardiac action likewise causes formation of uric acid. Since ever, the authors demonstrated that the bladder contained urine. in essential hypertension and in acute nephritis the cardiac action Roentgen examination following the injection of a contrast is increased, it may be assumed that in benign renal sclerosis, medium revealed a marked distention of the bladder. The and to a certain degree also in acute nephritis, the increased authors believe that the retention of urine was caused by hyper- uric acid content of the blood is not always caused by an insuf¬ excitability of the sympathetic nervous system, which resulted ficient elimination but may also be due to an increased formation. in relaxation of the external layer of the muscular tunic of the However, additional investigations will be necessary to demon¬ bladder. strate this definitely. Many observations indicate that the Hypermineralization Following Intensive Antirachitic retention of intestinal putrefaction products is an important factor in the in Treatment.—Opitz describes twins, aged 1 year and 3 months, pathogenesis of uremia. Differences the blood conditions that resemble those who, although they had not presented any signs of had existing between acute nephritis rickets, and contracted been given intensive antirachitic treatment prophylactically kidney also exist in various forms of sclerosis. If in the course of a renal (viosterol, a cod liver oil preparation containing phosphorus, and benign sclerosis the aromatic sub¬ ultraviolet irradiations). When examined by the author, neither stances gradually increase, that is, if the xanthoproteic and indican in serum of the infants showed clinical or of but values the increase, this is an early indication roentgen signs rickets, that at each end of the diaphysis of the long bones of both infants the sclerosis is becoming malignant. In the course of a benign sclerosis there sometimes occur isolated increases in there was a wide band shaped shadow, which on more careful the urea and in the uric acid content of the blood. these observation was found to consist of three narrower band shaped However, conditions alone are not indicative of a sclerosis. If shadows separated by lighter zones. Dark shadow's were noted malignant urea and uric acid alone increase, also in the bones of the pelvis, the scapulae, the clavicles, the the renal disturbance does not necessarily lead to contracted transverse processes of the vertebrae and the ends of kidney. adjacent and the ribs, the distal and proximal epiphyses of the phalanges and Relation Between Diabetes Disturbances of Biliary Tract.—Stimulated the of Katsch at the base of the cranium. Although the hypermineralization by investigations and VVöhr- who found that a relation exists at the end of the long bones had not retarded the growth of the mann, between diabetes and disturbances in the tract, made observations on children, the author believes that, in consideration of a possible biliary Bingel 114 diabetic and on 183 with disorders harmful hypermineralization of the internal organs, great care patients patients of the liver and of the tract. should be exercised in the use of irradiated substances in the biliary He found that 17 per cent 114 prophylaxis of rickets. of the diabetic patients had symptoms in the epigastric region that indicated either a former or a simultaneous disorder Münchener medizinische Munich in the biliary system. In three instances it could be definitely Wochenschrift, that diabetes had as a 77:473-520 (March 21) 1930 proved developed secondary disease. Among 183 patients with disturbances of the liver and its Studies on Physiology of Sex: Effect of Hormone of Anterior Lobe of Hypophysis on Immature Male Mice. M. Borst, . Döderlein and excretory ducts, a temporary glycosuria was found in only D. Gostimirovic.—p. 473. three instances. In juvenile and in senile diabetic patients, a Diagnostic Provocation of Cancer. S. 475. Beck.—p. correlation between the two diseases is evidently rare. How¬ I titerferometi y in Early Diagnosis of Cancer. E. Lendel.—p. 476. middle it is more •Prognosis in Renal Sclerosis Based on Chemical Examination of Blood: ever, during age apparently frequent than is Significance of Early Determination of Increase of Aromatic Intestinal usually assumed. The author thinks it necessary that the Putrefaction Products in Blood. E. Becher.—p. 477. problem should be studied on a larger clinical material. He Differential Diagnosis of Congested Kidney. F. Lebermann.—p. 479. advises that in diabetic •Relation Between Diabetes and Disturbances of Biliary Tract. Bingel. especially patients the anamnesis should —p. 4SI. tell whether the patient has previously suffered from disorders Researches with Graduated Photometer: Determination of Paternity, of the liver or of the bile ducts. Mother-Child Reaction, Pregnancy Reaction. E. Italian.—p. 483. in Psittacosis.—Pesch •Pathogenic Agent in Psittacosis. K. L. Pesch.—p. $84. Pathogenic Agent describes investi¬ •Treatment of Intermittent Claudication. H. Schauder.—p. 485. gations for the detection of the pathogenic agent of psittacosis. Reducing Cures in Practice. A. Kimmerle.—p. 487. He made bactériologie and serologie tests on material from Criticism of Tests for Cardiac Function. E. and H. Spohr Lampert.— with psittacosis and on the cadavers of those who had P. 491. C'en. patients Development of Adherent Lenses: Claim for Priority. A. E. Fick.— died from the disease. He also made experiments on parrots. p. 495. He comes to the conclusion that neither bacteria of the para¬ Is of of Glass Ingestion Particles Injurious or Harmless? E. Lüdecke. nor are the cause of 496. typhoid group streptococci psittacosis. In —p. accordance with Elkeles (München, vied. IVchuschr. 77:139 Prognosis in Renal Sclerosis: Significance of Intestinal [Jan. 24] 1930; abstr. The Journal, April 12, 1930, p. 1186) Putrefaction Products in Blood.—Becher directs attention he states that there is an essential difference between the psit¬ to the fact that in former researches it had been demonstrated tacosis that parrots transmit to human beings and the contagious that the renal insufficiency in acute nephritis without anuria disorder occurring in parrots, which is caused by Bacterium differed markedly from the renal insufficiency in patients with paralypliosuin-cntcritidis Breslau. In the heart blood of the contracted kidney. In acute nephritis the blood shows early birds that had died of the disease, spirochetes could not be an increased content of urea and uric acid, whereas the intestinal detected either in the dark field or in the Giemsa preparation. putrefaction products, such as indole, phenol, cresol, diphenyl, Because of the negative microscopic results and of the negative aromatic oxygen acids and indolacetic acid, are not at all cultures, the author advances the theory that the disease is increased, or appear comparatively late or only in minute quan- caused by an invisible filtrable virus. The following observa-

Downloaded From: http://jama.jamanetwork.com/ by a University of Arizona Health Sciences Library User on 05/29/2015 tions support this theory: 1. The microscopic tests gave nega¬ Kazansky Meditsinsky Jurnal, Kazan tive results in all birds that had died of the disease. 2. The 86: 235-336 (March) 1930 cultures were nearly all negative, aerobic as well as anaerobic. Acquired Immunity to Syphilis. V. M. Aristovsky.—p. 239. Usually, in the few instances in which bacteria were found, Pneumoseope: Diagnostic Value. R. I. Shtekeiis.—p. 255. Sedimentation Test in Rheumatic either were were 'Erythrocyte Polyarthritis: Prognostic they due to impurities or putrefactive bacteria, Value. M. L. Meerovitch.—p. 259. but they were not the causative agent of psittacosis. 3. With Use of Beer in Developing Conditioned Reflex. A. Y. Pleshchitzer.—- bacteria-free filtrates of the heart blood or of the liver from p. 262. Diaphragmatic Hernia: Carcinoma of Stomach. A. I. Kondrashkin.— birds that had died of the it was to infect disease, possible p. 267. eleven other parrots. Aerobic and anaerobic cultures from the Study of Functioning of Kidney by Use of Sodium Salicylate. L. P. heart blood or from the liver of the animals thus infected like¬ Krayzelburd.—p. 272. in Metal Workers. A. 1. Ivantcbenko. 274. wise remained sterile. That contact infection is is Tendovaginitis Crepatane p. possible Local Anesthesia Used in Operating on Fibroma at Base of Skull (Post- proved by the fact that two healthy birds contracted the disease nasal Wall). I. V. Domratchev.—p. 278. when they were brought into an unsterilized cage in which a Suppurative Appendicitis. M. P. Shatkisky.—p. 281. Treatment for Inllammation of T. S. 283. had died. That not all the inoculated contracted Vagina. Andreytchuk.—p. parrot parrots Prophylaxis of Chickenpox. M. A. Degtyareva.—p. 287. the disease is explained by the author as being due to the fact Endemie Goiter. M. P. Andreev and M. G. Ulyanov.—p. 290. that they had all been raised in Europe. He thinks that the Occupational Dermatitis in Peasants. K. A. Promachin.—p. 299. psittacosis virus is perhaps not so virulent for these birds as Sedimentation Test in Rheumatic Polyarthritis.— for those that have been raised in tropical regions. Meerovitch, on the basis of his study of ninety patients, Treatment of Intermittent Claudication. Schauder concludes that in rheumatic polyarthritis the erythrocyte sedi¬ — between and 1.2 cm. in an reports the case of a patient who for more than a year had mentation rate varies 0.5 hour, depend¬ on acuteness The d from severe intermittent claudication and from arterio¬ ing largely the of the disease. erythrocyte sclerosis. The usual treatment with iodine, glyceryl trinitrate sedimentation rate is reduced when the patient is treated for a rheumatic but it is not reduced in to and alternating baths either failed completely or brought only polyarthritis, proportion the of the If the is released temporary improvement. Then an injection treatment with rapidity patient's recovery. patient from treatment before the sedimentation rate has a circulation hormone was instituted. This circulation hormone erythrocyte reached normal, symptoms of rheumatic polyarthritis recur three was first demonstrated by Frey and Kraut. They extracted it weeks after institution of the first treatments ; it is therefore from the urine. The hormone is produced in the pancreas, necessary to treat the patient until the erythrocyte sedimentation circulates in the blood stream and is excreted unchanged in rate is normal to prevent a recurrence of the symptoms. the urine. Animal experiments have proved that it has a vaso¬ dilator effect on the vessels. It also causes lowering peripheral Nederlandsch Tijdschrift voor Geneeskunde, Haarlem of the blood pressure, increase in the pulse amplitude and some- 74: 1021-1176 (March 1) 1930 increase in the number of heart beats. The decrease in Malignant Diphtheria. E. Gorter.—p. 1022. the blood pressure is caused not by a weakening of the heart •Influence of Vitamine A, B, C and D and of Calcium and Phosphorus on Recovery from Bone Fractures. M. N. RoeghcJt.—p. 1028. action but rather by the vasodilator effect. This factor seemed Postvaccinal Encephalitis with Absence of Local Reactions: Together especially significant in the case reported. The patient was with Remarks on Pathohistology of Postvaccinal Encephalitis. A. given twice daily subcutaneous injections of the circulation Querido.—p. 1047. Surgical Treatment of Fistulas of Pancreas. R. Brummelkamp.—p. 1056. hormone. At first one-half unit was administered. Grad¬ only What Is a Fully Developed Pock Pustule? What Is a Good Result in ually this amount was increased to 2 units. The treatment was Smallpox Vaccination? D. J. Kuiper.—p. 106.2. continued for two weeks. After its completion the patient was Donders as Pathologist and Anatomist. K. de .Tosselin de Jong.—p. I let. in Vaccination. der able to take walks without troubled At Smallpox Eighteenth Century: J. J. van Kleij. again being by pains. —p. 1084. first slight attacks of paresthesia recurred, but they disappeared Influence of Vitamins A, B, C and D and of Calcium gradually and the patient was able to walk long distances with¬ and on Recovery from Bone Fractures.— out The results of this hormonal have Phosphorus difficulty. good therapy concludes from his observations that persisted for thirteen months. Roegholt recovery from bone fractures in India in natives and in those partaking of die¬ sarne diet is slower than in Netherlanders Wiener klinische Vienna in the Netherlands Wochenschrift, (or in India, if they follow a European diet). Vitamin A has 43:353-384 (March 20) 1930 no effect on regeneration of bone but a lack of Its Relation to Patho¬ fracture, possibly Significance and Problems General Pathology: of vitamin and of calcium and is for logic Anatomy, to Physiology, to Clinical Pathology and to Therapy. phosphorus responsible F. Standenath.—p. 353. the slower regeneration of bone fractures in the natives. Melanin Reaction in Urine Following Exposure to Sun Rays. E. Risak. —p. 358. Bronchiectasis Childhood. F. 361. Hospitalstidende, Copenhagen . Treatment of During Basch.—p. 73: 1-2X (Jan. 2) 1930 the Treatment of Fresh and of Old Wounds. M. Levai.— •Insulin in •Gonorrhea) Arthritis. S. A. Holb^ll.—p. 18. p. 362. 'Myxedema with Cerebellar Symptoms: Case. E. 25. Cervix Uteri: Its Structure, and Significance and Mechanism of Its Rud.—p. Dilation. G. Weidenbaum.—p. 365. Gonorrheal Arthritis, Particularly with Regard to Constitutional Anomalies of Thorax and of DiapUragm. K. Hitzenberger. Complement Fixation Reaction for Gonorrhea.—Holb011 367. —p. says that in 230 cases of nonsurgical arthritis, a clinical diag¬ Insulin in Treatment of Wounds.—Levai recommends the nosis of gonorrheal arthritis was made in twenty-nine, all of local application of insulin for the treatment of fresh as well which gave a positive complement fixation reaction for gonor¬ as of old wounds. The wound is covered with a layer of rhea ; among the other cases there was a weak or doubtful gauze which has been moistened with about 5 units of insulin. reaction in only four. The reaction does not become positive The gauze is fastened with strips of adhesive tape so that air until the beginning of the second week of the disorder, rising can reach the wound. The author stresses that wounds then to a maximum that varies in the different cases. The should never be covered so as to exclude the air completely. He reaction was positive in four patients with a history of gonor- found that the insulin hastened the healing process. The i heal arthritis from five to seven years ago who now present hormone evidently influences the formative elements of mesen- symptoms of chronic arthritis. chymal origin. However, its effect on epithelization is only Myxedema with Cerebellar Symptoms: Case.—In Rud's slight or entirely absent. The wound therapy with insulin instance of myxedema in a man, aged 69, it is believed that proved to be harmless. In cases in which as much as 40 units the condition originated on an arteriosclerotic basis, roentgen was applied, hypogh-cernia was not noted. The granulation examination having established calcifications in the superior surfaces absorb the insulin either not at all or only in minute thyroid artery. The marked cerebellar symptoms—asynergy, quantities. The insulin should be applied to the bandage rather dysmetria, ataxia and adiadokokinesis yielded to treatment than to the wound. with thyroidin. —

Downloaded From: http://jama.jamanetwork.com/ by a University of Arizona Health Sciences Library User on 05/29/2015