Curriculum Vitae: Jaffer A. Ajani, MD
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Options for the Treatment of Gemcitabine-Resistant Advanced Pancreatic Cancer
JOP. J Pancreas (Online) 2010 Mar 5; 11(2):113-123. REVIEW Options for the Treatment of Gemcitabine-Resistant Advanced Pancreatic Cancer Ioannis Gounaris, Kamarul Zaki, Pippa Corrie Oncology Centre, Cambridge University Hospitals NHS Trust. Cambridge, United Kingdom Summary Context Pancreatic cancer is noteworthy in that the number of patients dying from the disease is roughly equal to the number diagnosed. For more than a decade, gemcitabine has constituted the standard of care for the palliative treatment of the majority of patients who present with metastatic or relapsed disease, although the survival gains are limited. Despite a median survival of less than 6 months, there is a significant proportion of advanced pancreatic cancer patients who progress on gemcitabine that remains fit and these patients are candidates for second-line treatment. Methods The OVID MEDLINE database was searched from 1950 to present using the MeSH terms “pancreatic neoplasms”, “drug treatment” and “gemcitabine”. After excluding non-relevant results, 31 published studies were identified. These results were supplemented by searching the last three (2007-2009) American Society of Clinical Oncology (ASCO) Proceedings of Annual Meetings for studies published only in abstract form and reviewing reference lists of published articles. Results and discussion The evidence for second line treatments of metastatic pancreatic cancer consists mostly of single arm, small phase II studies. Oxaliplatin-fluoropyrimidine combinations appear promising and have shown increased survival compared to best supportive care. As the molecular pathways governing pancreatic cancer are unravelled, novel targeted therapies may offer the greatest promise for this disease either given alone, combined with one another, or with cytotoxic agents. -
Research in Your Backyard Developing Cures, Creating Jobs
Research in Your Backyard Developing Cures, Creating Jobs PHARMACEUTICAL CLINICAL TRIALS IN ILLINOIS Dots show locations of clinical trials in the state. Executive Summary This report shows that biopharmaceutical research com- Quite often, biopharmaceutical companies hire local panies continue to be vitally important to the economy research institutions to conduct the tests and in Illinois, and patient health in Illinois, despite the recession. they help to bolster local economies in communities all over the state, including Chicago, Decatur, Joliet, Peoria, At a time when the state still faces significant economic Quincy, Rock Island, Rockford and Springfield. challenges, biopharmaceutical research companies are conducting or have conducted more than 4,300 clinical For patients, the trials offer another potential therapeutic trials of new medicines in collaboration with the state’s option. Clinical tests may provide a new avenue of care for clinical research centers, university medical schools and some chronic disease sufferers who are still searching for hospitals. Of the more than 4,300 clinical trials, 2,334 the medicines that are best for them. More than 470 of the target or have targeted the nation’s six most debilitating trials underway in Illinois are still recruiting patients. chronic diseases—asthma, cancer, diabetes, heart dis- ease, mental illnesses and stroke. Participants in clinical trials can: What are Clinical Trials? • Play an active role in their health care. • Gain access to new research treatments before they In the development of new medicines, clinical trials are are widely available. conducted to prove therapeutic safety and effectiveness and compile the evidence needed for the Food and Drug • Obtain expert medical care at leading health care Administration to approve treatments. -
SEATU Leadership Visits Piney Point
The Official Publication of the Seafarers Entertainment and Allied Trades Union, Affiliated with the Seafarers International Union, AGLIW, AFL-CIO. Volume 21, Number 1 January-March 2018 The Also available online at www.seatu.org ENTERTAINER SERVICE • HOSPITALITY • GAMING SEATU Leadership Visits Piney Point Members of SEATU’s leadership recently trav- elled to the union-affiliated Paul Hall Center for Maritime Training and Education in Piney Point, Maryland, to attend a series of classes that fo- cused on building and im- proving leadership skills. In the photo at left, SEATU officials and rep- resentatives assembled in the auditorium. Additional photos can be found on Page 8. From left to right: Assis- tant Representative Sha- ron Cipolla, Assistant Vice President Karen Horton- Gennette, Representative Chad Partridge, Assistant Vice President Bryan Powell, Representative Patti Christian, Represen- tative Gerard Dhooge, Representative Ashley Smith, Representative Tyson Little, Representa- tive Amber Akana, SIU Port Agent John Hoskins and Representative Shane Sterry. Workers’ Rights at Stake in Crucial Supreme Court Case Editor’s note: The following piece was Some of those non-members pay Kagan. That includes the non-members, so-called right-to-work. Kennedy, for written by Mark Gruenberg, editor, Press agency fees. The others, in right-to-work he added. example, reeled off a list of issues he Associates News Service. states, are “free riders.” A decision for “A two-tiered workplace” where some said public sector unions are involved Mark Janus and the right-to-work crowd people pay dues and the rest are free rid- in, starting with raising taxes. And Alito “Agency fees,” paid by non-union would automatically make all 6.8 million ers “would be corrosive to collaboration suggested that even raising grievances public workers whom unions represent in state and local government workers “free and cooperation,” he added. -
Tanibirumab (CUI C3490677) Add to Cart
5/17/2018 NCI Metathesaurus Contains Exact Match Begins With Name Code Property Relationship Source ALL Advanced Search NCIm Version: 201706 Version 2.8 (using LexEVS 6.5) Home | NCIt Hierarchy | Sources | Help Suggest changes to this concept Tanibirumab (CUI C3490677) Add to Cart Table of Contents Terms & Properties Synonym Details Relationships By Source Terms & Properties Concept Unique Identifier (CUI): C3490677 NCI Thesaurus Code: C102877 (see NCI Thesaurus info) Semantic Type: Immunologic Factor Semantic Type: Amino Acid, Peptide, or Protein Semantic Type: Pharmacologic Substance NCIt Definition: A fully human monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2), with potential antiangiogenic activity. Upon administration, tanibirumab specifically binds to VEGFR2, thereby preventing the binding of its ligand VEGF. This may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR2 is a pro-angiogenic growth factor receptor tyrosine kinase expressed by endothelial cells, while VEGF is overexpressed in many tumors and is correlated to tumor progression. PDQ Definition: A fully human monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2), with potential antiangiogenic activity. Upon administration, tanibirumab specifically binds to VEGFR2, thereby preventing the binding of its ligand VEGF. This may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR2 is a pro-angiogenic growth factor receptor -
Chemotherapy for Metastatic Breast Cancer (MBC)
Clinical Conversations Between an Oncology Nurse and Oncology Pharmacist During the Treatment of Patients With Breast Cancer: A Focus on Oral Chemotherapeutic Formulations © 2020. All rights reserved. No part of this report may be reproduced or distributed without the expressed written permission of PTCE. Faculty Information Chair Danielle Roman, PharmD, BCOP Manager, Clinical Pharmacy Services Allegheny Health Network Pittsburgh, Pennsylvania Allison Butts, PharmD, BCOP Kandra Horne, DNP, APRN, WHNP-BC Clinical Coordinator, Oncology Pharmacy Women’s Health Care Nurse Practitioner UK HealthCare Breast and GYN Oncology: Medical Oncology Assistant Adjunct Professor Winship Cancer Institute: Emory Healthcare UK College of Pharmacy Atlanta, Georgia Lexington, Kentucky This activity is supported by an educational grant from Athenex. Educational Objectives At the completion of this activity, participants will be able to: • Distinguish optimized treatment approaches for breast cancer based on disease- and patient-specific factors and potential places in therapy for oral formulations • Analyze the results of recent clinical trials with recently approved and emerging treatment options to inform the appropriate management of adverse effects and adherence for patients with breast cancer • Examine the benefits of multidisciplinary care across multiple practice environments for patients with breast cancer to optimize patient outcomes Evolving Oral Chemotherapeutic Opportunities in Breast Cancer Care Danielle Roman, PharmD, BCOP Manager, Clinical Pharmacy -
Identification of Repurposed Drugs for Chordoma Therapy
Identification of Repurposed Drugs for Chordoma Therapy. Menghang Xia, Ph.D. Division of Pre-Clinical Innovation National Center for Advancing Translational Sciences National Institutes of Health Fourth International Chordoma Research Workshop Boston, March 22, 2013 NIH Chemical Genomics Center Founded in 2004 • National Center for Advancing Translational Sciences (NCATS) • >100 staff: Biologists, Chemists, Informatics and Engineers Robotic HTS facility Mission • Development of chemical probes for novel biology • Novel targets, rare/neglected diseases • New technologies/paradigms for assay development, screening, informatics, chemistry Collaborations • >200 investigators worldwide • 60% NIH extramural • 25% NIH intramural • 15% Foundations, Research Consortia, Pharma/Biotech Steps in the drug development process Make Create Test modifications Test in Test in testing >100,000 to active animals for humans for system chemicals for chemicals to safety, safety, (aka, activity on make suitable effectiveness effectiveness “assay”) target for human use Two approaches to therapeutics for rare and neglected diseases 1-2 years? >400,000 compounds, 15 yrs Lead Preclinical Clinical Screen Hit Lead Optimization Development Trials 3500 drugs The NCGC Pharmaceutical Collection Procurement in Drug Source In house process Total US FDA* 1635 182 1817 UK/EU/Canada/Japan 756 177 933 Total Approved 2391 359 2750 Investigational 928 3953 4881 Total 3319 4312 7631 * These counts include approved veterinary drugs Informatics sources for NPC o US FDA: Orange Book, OTC, NDC, Green Book, Drugs at FDA o Britain NHS o EMEA o Health Canada o Japan NHI Physical sources for NPC o Procurement from >70 suppliers worldwide o In-house purification of APIs from marketed forms Drug plate composition o Synthesis Comprehensive Drug Repurposing Library Access to the NPC (http://tripod.nih.gov/npc/) Chordoma Screening Project • Cell lines Chordoma cell lines screened: U-CH1 and U-CH2B . -
Modifications to the Harmonized Tariff Schedule of the United States To
U.S. International Trade Commission COMMISSIONERS Shara L. Aranoff, Chairman Daniel R. Pearson, Vice Chairman Deanna Tanner Okun Charlotte R. Lane Irving A. Williamson Dean A. Pinkert Address all communications to Secretary to the Commission United States International Trade Commission Washington, DC 20436 U.S. International Trade Commission Washington, DC 20436 www.usitc.gov Modifications to the Harmonized Tariff Schedule of the United States to Implement the Dominican Republic- Central America-United States Free Trade Agreement With Respect to Costa Rica Publication 4038 December 2008 (This page is intentionally blank) Pursuant to the letter of request from the United States Trade Representative of December 18, 2008, set forth in the Appendix hereto, and pursuant to section 1207(a) of the Omnibus Trade and Competitiveness Act, the Commission is publishing the following modifications to the Harmonized Tariff Schedule of the United States (HTS) to implement the Dominican Republic- Central America-United States Free Trade Agreement, as approved in the Dominican Republic-Central America- United States Free Trade Agreement Implementation Act, with respect to Costa Rica. (This page is intentionally blank) Annex I Effective with respect to goods that are entered, or withdrawn from warehouse for consumption, on or after January 1, 2009, the Harmonized Tariff Schedule of the United States (HTS) is modified as provided herein, with bracketed matter included to assist in the understanding of proclaimed modifications. The following supersedes matter now in the HTS. (1). General note 4 is modified as follows: (a). by deleting from subdivision (a) the following country from the enumeration of independent beneficiary developing countries: Costa Rica (b). -
Thrf-2019-1-Winners-V3.Pdf
TO ALL 21,100 Congratulations WINNERS Home Lottery #M13575 JohnDion Bilske Smith (#888888) JohnGeoff SmithDawes (#888888) You’ve(#105858) won a 2019 You’ve(#018199) won a 2019 BMWYou’ve X4 won a 2019 BMW X4 BMWYou’ve X4 won a 2019 BMW X4 KymJohn Tuck Smith (#121988) (#888888) JohnGraham Smith Harrison (#888888) JohnSheree Smith Horton (#888888) You’ve won the Grand Prize Home You’ve(#133706) won a 2019 You’ve(#044489) won a 2019 in Brighton and $1 Million Cash BMWYou’ve X4 won a 2019 BMW X4 BMWYou’ve X4 won a 2019 BMW X4 GaryJohn PeacockSmith (#888888) (#119766) JohnBethany Smith Overall (#888888) JohnChristopher Smith (#888888)Rehn You’ve won a 2019 Porsche Cayenne, You’ve(#110522) won a 2019 You’ve(#132843) won a 2019 trip for 2 to Bora Bora and $250,000 Cash! BMWYou’ve X4 won a 2019 BMW X4 BMWYou’ve X4 won a 2019 BMW X4 Holiday for Life #M13577 Cash Calendar #M13576 Richard Newson Simon Armstrong (#391397) Win(#556520) a You’ve won $200,000 in the Cash Calendar You’ve won 25 years of TICKETS Win big TICKETS holidayHolidays or $300,000 Cash STILL in$15,000 our in the Cash Cash Calendar 453321 Annette Papadulis; Dernancourt STILL every year AVAILABLE 383643 David Allan; Woodville Park 378834 Tania Seal; Wudinna AVAILABLE Calendar!373433 Graeme Blyth; Para Hills 428470 Vipul Sharma; Mawson Lakes for 25 years! 361598 Dianne Briske; Modbury Heights 307307 Peter Siatis; North Plympton 449940 Kate Brown; Hampton 409669 Victor Sigre; Henley Beach South 371447 Darryn Burdett; Hindmarsh Valley 414915 Cooper Stewart; Woodcroft 375191 Lynette Burrows; Glenelg North 450101 Filomena Tibaldi; Marden 398275 Stuart Davis; Hallett Cove 312911 Gaynor Trezona; Hallett Cove 418836 Deidre Mason; Noarlunga South 321163 Steven Vacca; Campbelltown 25 years of Holidays or $300,000 Cash $200,000 in the Cash Calendar Winner to be announced 29th March 2019 Winners to be announced 29th March 2019 Finding cures and improving care Date of Issue Home Lottery Licence #M13575 2729 FebruaryMarch 2019 2019 Cash Calendar Licence ##M13576M13576 in South Australia’s Hospitals. -
Horizon Scanning Status Report, Volume 2
PCORI Health Care Horizon Scanning System Volume 2, Issue 3 Horizon Scanning Status Report September 2020 Prepared for: Patient-Centered Outcomes Research Institute 1828 L St., NW, Suite 900 Washington, DC 20036 Contract No. MSA-HORIZSCAN-ECRI-ENG-2018.7.12 Prepared by: ECRI Institute 5200 Butler Pike Plymouth Meeting, PA 19462 Investigators: Randy Hulshizer, MA, MS Damian Carlson, MS Christian Cuevas, PhD Andrea Druga, PA-C Marcus Lynch, PhD, MBA Misha Mehta, MS Prital Patel, MPH Brian Wilkinson, MA Donna Beales, MLIS Jennifer De Lurio, MS Eloise DeHaan, BS Eileen Erinoff, MSLIS Cassia Hulshizer, AS Madison Kimball, MS Maria Middleton, MPH Diane Robertson, BA Melinda Rossi, BA Kelley Tipton, MPH Rosemary Walker, MLIS Andrew Furman, MD, MMM, FACEP Statement of Funding and Purpose This report incorporates data collected during implementation of the Patient-Centered Outcomes Research Institute (PCORI) Health Care Horizon Scanning System, operated by ECRI under contract to PCORI, Washington, DC (Contract No. MSA-HORIZSCAN-ECRI-ENG-2018.7.12). The findings and conclusions in this document are those of the authors, who are responsible for its content. No statement in this report should be construed as an official position of PCORI. An intervention that potentially meets inclusion criteria might not appear in this report simply because the Horizon Scanning System has not yet detected it or it does not yet meet inclusion criteria outlined in the PCORI Health Care Horizon Scanning System: Horizon Scanning Protocol and Operations Manual. Inclusion or absence of interventions in the horizon scanning reports will change over time as new information is collected; therefore, inclusion or absence should not be construed as either an endorsement or rejection of specific interventions. -
Patent Application Publication ( 10 ) Pub . No . : US 2019 / 0192440 A1
US 20190192440A1 (19 ) United States (12 ) Patent Application Publication ( 10) Pub . No. : US 2019 /0192440 A1 LI (43 ) Pub . Date : Jun . 27 , 2019 ( 54 ) ORAL DRUG DOSAGE FORM COMPRISING Publication Classification DRUG IN THE FORM OF NANOPARTICLES (51 ) Int . CI. A61K 9 / 20 (2006 .01 ) ( 71 ) Applicant: Triastek , Inc. , Nanjing ( CN ) A61K 9 /00 ( 2006 . 01) A61K 31/ 192 ( 2006 .01 ) (72 ) Inventor : Xiaoling LI , Dublin , CA (US ) A61K 9 / 24 ( 2006 .01 ) ( 52 ) U . S . CI. ( 21 ) Appl. No. : 16 /289 ,499 CPC . .. .. A61K 9 /2031 (2013 . 01 ) ; A61K 9 /0065 ( 22 ) Filed : Feb . 28 , 2019 (2013 .01 ) ; A61K 9 / 209 ( 2013 .01 ) ; A61K 9 /2027 ( 2013 .01 ) ; A61K 31/ 192 ( 2013. 01 ) ; Related U . S . Application Data A61K 9 /2072 ( 2013 .01 ) (63 ) Continuation of application No. 16 /028 ,305 , filed on Jul. 5 , 2018 , now Pat . No . 10 , 258 ,575 , which is a (57 ) ABSTRACT continuation of application No . 15 / 173 ,596 , filed on The present disclosure provides a stable solid pharmaceuti Jun . 3 , 2016 . cal dosage form for oral administration . The dosage form (60 ) Provisional application No . 62 /313 ,092 , filed on Mar. includes a substrate that forms at least one compartment and 24 , 2016 , provisional application No . 62 / 296 , 087 , a drug content loaded into the compartment. The dosage filed on Feb . 17 , 2016 , provisional application No . form is so designed that the active pharmaceutical ingredient 62 / 170, 645 , filed on Jun . 3 , 2015 . of the drug content is released in a controlled manner. Patent Application Publication Jun . 27 , 2019 Sheet 1 of 20 US 2019 /0192440 A1 FIG . -
Register of Burials As at 6 December 2019
Register of Burials as at 6 December 2019 Family Name Christian Names Cemetery Division Section Plot No Date of Death Age Gender Place of Birth ABBOTT BEATRICE MARY M New Ingham Roman Catholic 36 56 16/02/1989 75 F ST KILDA ABBOTT CHARLES Old Ingham Anglican 0 1,294 12/05/1939 0 M UNKNOWN ABBOTT HENRY TERRY New Ingham Roman Catholic 36 55 8/04/1997 85 M INGHAM ABDOOLAH Old Ingham Mixed Denomination 0 52 12/11/1903 55 M INDIA ABEL ISABEL JANE New Ingham Anglican 17 921 24/06/2008 84 F INGHAM ABEL ROY OSBOURNE New Ingham Anglican 17 922 20/02/2016 88 M Townsville, Queensland ABORIGINAL Old Ingham Mixed Denomination 0 122 17/12/1911 0 F UNKNOWN ABORIGINAL Old Ingham Mixed Denomination 0 529 8/04/1925 0 F INGHAM ABORIGINAL Old Ingham Mixed Denomination 0 0 16/05/1916 0 F ABORIGINAL Old Ingham Mixed Denomination 0 0 26/06/1916 0 M ABORIGINAL Old Ingham Mixed Denomination 0 0 10/03/1917 0 F ABORIGINAL Old Ingham Mixed Denomination 0 0 29/04/1917 0 F ABORIGINAL Old Ingham Mixed Denomination 0 0 28/10/1917 0 M ABORIGINAL Old Ingham Mixed Denomination 0 0 19/07/1919 0 M ABORIGINAL Old Ingham Mixed Denomination 0 0 22/07/1919 0 M ABORIGINAL Old Ingham Mixed Denomination 0 0 30/07/1919 0 ABORIGINAL Old Ingham Mixed Denomination 0 0 4/08/1919 0 ABORIGINAL Old Ingham Mixed Denomination 0 0 0 ABORIGINAL Old Ingham Mixed Denomination 0 0 20/12/1922 0 F ABORIGINAL Old Ingham Mixed Denomination 0 0 25/07/1923 0 F ABORIGINAL Old Ingham Mixed Denomination 0 0 20/11/1923 0 M ABORIGINAL Old Ingham Mixed Denomination 0 0 29/01/1924 0 M ABORIGINAL Old Ingham Mixed Denomination 0 0 12/04/1924 0 M ABORIGINAL BABY Old Ingham Mixed Denomination 0 529 8/04/1925 0 F INGHAM ABORIGINAL No Record - Unknown Old Ingham Mixed Denomination 0 166 24/09/1913 0 UNKNOWN ABORIGINAL ROSIE Old Ingham Mixed Denomination 0 0 14/08/1924 0 F ABRAHAM RICHARD Halifax Mixed Denomination 45 11 10/11/1921 56 M ENGLAND ABRAHAM STANLEY EMMETT New Ingham R.S.L. -
A and No Surname
-A- Surname Index and without a surname St. Clair County Genealogical Society Quarterly Volumes 1–40 (1978-2017) Nuns are indexed under “S” as Sister [given name] To find all instances of your family name, search for variants caused by poor handwriting, misinterpretation of similar letters or their sounds. A few such examples are L for S, c for e, n for u, u for a; phonetic spellings (Aubuchon for Oubuchon); abbreviations (M’ for Mc); single letters for double (m for mm, n for nn); translations (King for Roy, Carpenter for Zimmermann). Other search tips: substitute each vowel for other ones, search for nicknames, when hyphenated – search for each surname alone, with and without “de” or “von”; with and without a space or apostrophe (Lachance and La Chance, O’Brien and OBRIEN). More suggestions are on the SCCGS website Quarterly pages at https://stclair-ilgs.org . Surname Vol. Issue Page(s) Surname Vol. Issue Page(s) Surname Vol. Issue Page(s) ___ , Cunagunda Isabella27 2 81 ___, George 24 3 108 ___, unknown 34 2 87, 89, 91, 93, ___ , Eugene 33 2 62 ___, George H. 24 3 111 96, 101 ___ , female child 33 3 135 ___, Illegible 27 1 32, 37 ___, unknown 34 3 150, 156 ___ , female infant 30 4 217 ___, Illia 24 3 116 ___, unknown 35 2 63, 73, 77 ___ , female newborn 33 2 65, 69 ___, INDIANS 16 2 109 ___, unknown 35 2 69, 70, 76 ___ , female, 25y 31 2 65 ___, Infant 38 1 45 ___, unknown 35 3 161, 162, 154 ___ , female, age 32 31 1 29 ___, Infant 38 2 92 ___, unknown 36 1 95, 96, 98, 110 ___ , Jacob 26 2 98 ___, Jacco 16 2 91 ___, unknown 36 3 122