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(12) Patent Application Publication (10) Pub. No.: US 2017/0143644 A1 Carberry (43) Pub US 20170143644A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2017/0143644 A1 Carberry (43) Pub. Date: May 25, 2017 (54) COMPOSITION OF OLIVETOL AND (60) Provisional application No. 62/258,979, filed on Nov. METHOD OF USE TO REDUCE OR INHIBIT 23, 2015. THE EFFECTS OF TETRAHYDROCANNABINOL IN THE Publication Classification HUMAN BODY (51) Int. Cl. A63L/05 (2006.01) (71) Applicant: Undoo, LLC, Mesa, AZ (US) A69/48 (2006.01) (72) Inventor: James J. Carberry, Mesa, AZ (US) (52) U.S. Cl. CPC ............ A6 IK3I/05 (2013.01); A61K 9/4875 (2013.01); A61K 9/4858 (2013.01); A61 K (73) Assignee: Undoo, LLC, Mesa, AZ (US) 9/4825 (2013.01) (21) Appl. No.: 15/417,179 (57) ABSTRACT Filed: Jan. 26, 2017 Embodiments of the present invention relate to the use of a (22) therapeutically-effective amount of Olivetol to reduce, eliminate, inhibit or alleviate the psychoactive effects of Related U.S. Application Data THC in users of Cannabis. Further embodiments of the (63) Continuation of application No. 15/360,389, filed on present invention relate to a softgel, tablet or capsule of Nov. 23, 2016. Olivetol in combination with an edible oil. US 2017/0143644 A1 May 25, 2017 COMPOSITION OF OLIVETOL AND receptors are naturally present and are activated by endo METHOD OF USE TO REDUCE OR INHIBIT cannabinoids that are produced by the human body for THE EFFECTS OF neural and cell signaling. In neurons, endocannabinoids bind TETRAHYDROCANNABINOL IN THE to the CB1 receptors at the pre-synaptic junction and, among HUMAN BODY other effects, impact the release of gamma-amino butyric acid (“GABA). However, when THC is present in the CROSS REFERENCE TO RELATED human bloodstream, it binds to these cannabinoid receptors APPLICATIONS and causes many different psychotropic effects. Consump 0001. The subject application claims priority to U.S. tion of Cannabis by a human generally results in a wide Provisional Patent Application Ser. No. 62/258,979, filed on variety of psychotropic effects, which is often referred to as Nov. 23, 2015, and U.S. Non-provisional Patent Application a “high. The cannabis high varies depending on many Ser. No. 15/360,389, filed on Nov. 23, 2016, which appli factors, including the strain of Cannabis, the amount con cations are incorporated herein in their entirety by this sumed, the method of consumption, the biochemistry of the reference thereto. individual consuming it and the individuals level of expe rience in consuming cannabis. That said, a cannabis high can TECHNICAL FIELD include euphoria, anxiety, a general alteration of conscious perception, feelings of well-being, relaxation or stress reduc 0002 The embodiments herein relate generally to use of tion, increased appreciation of humor, music (especially the compound Olivetol to reduce, alleviate, or inhibit the discerning its various components/instruments) or the arts, psychoactive effects of tetrahydrocannabinol in humans or joviality, metacognition and introspection, enhanced recol other mammals. lection (episodic memory), increased sensuality, increased awareness of sensation, increased libido, and creativity. BACKGROUND ART Abstract or philosophical thinking, disruption of linear 0003 Cannabis, also commonly known as marijuana, is a memory and paranoia or anxiety are also typical effects. flowering plant that includes three species or Sub-species, 0007 Cannabis consumption also often produces many namely sativa, indica and ruderalis. The plant is indigenous Subjective and highly tangible effects, such as greater enjoy to Central Asia and the Indian Subcontinent. Cannabis has ment of food taste and aroma, an enhanced enjoyment of long been used for hemp fiber, for oils, for medicinal music and comedy, and marked distortions in the perception purposes and as a recreational drug. Cannabis plants pro of time and space (where experiencing a “rush” of ideas duce a group of chemicals called cannabinoids. The majority from the bank of long-term memory can create the Subjec of these compounds are secreted by glandular trichromes tive impression of long elapsed time, while a clock reveals that occur abundantly on the floral calyxes and bracts of that only a short time has passed). Many individuals find female Cannabis plants. When used by humans medicinally Some of these effects pleasing and enjoyable, while other or recreationally, Cannabis is typically consumed either individuals do not enjoy such effects. eating or Smoking dried flower buds, resin, or various 0008 Although Cannabis has a high margin of safety, it extracted oils or waxes. can produce negative side effects. At higher doses in 0004. The most well-known cannabinoid is tetrahydro humans, effects can include altered body image, auditory cannabinol, often abbreviated as “THC. The chemical and/or visual illusions, pseudo-hallucinatory, and ataxia formula for THC is CHO and it has the following from selective impairment of polysynaptic reflexes. In some chemical structure: cases, in humans, cannabis can lead to dissociative states Such as depersonalization and derealization. Additionally, canine studies of very high doses of cannabis resulted in intoxication effects including depression, hypersalivation, mydriasis, hypermetria, vomiting, urinary incontinence, tremors, hypothermia, bradycardia, nystagmus, agitation, tachypnea, ataxia hyperexcitability and seizures. Occasion ally, heavy use, or use by inexperienced human consumers, particularly in an unfamiliar environment, can result in very negative experiences. Any episode of acute psychosis that accompanies cannabis use usually abates after 6 hours, but in rare instances heavy users may find the symptoms con tinuing for many days. If the episode is accompanied by 0005 THC is widely recognized as the principal psycho aggression or sedation, physical restraint may be necessary. active constituent in Cannabis. However, the Cannabis plant 0009. No known antidote presently exists for THC over produces hundreds of other cannabinoids, terpenoids and consumption or intoxication, nor any known medications for other compounds that are only beginning to be identified, treating cannabis dependence or withdrawal. Efforts have studied and categorized. It is believed by researchers that been made to discover or develop Such an antidote or many of these other cannabinoids, terpenoids and other medication, including experiments with Nabiximols, Preg compounds may have important health benefits and/or be nenolone, Rimonabant, and with intralipid therapy to bind to capable of treating certain human diseases. the highly lipophilic THC, none of which have proven 0006. There are two characterized cannabinoid receptors satisfactory. Other effects of THC and efforts to identify in the human body, CB1, which is primarily located in the antagonists to endocannabinoid receptors are discussed in central nervous system, and CB2 which is primarily located the paper, “Phytocannabinoids and Endocannabinoids.” in the immune system and blood cells. These cannabinoid Fisar, Zdenék, CURRENT DRUGABUSE REVIEWS (2009)2, 51-75, US 2017/0143644 A1 May 25, 2017 which is hereby incorporated by reference as if set forth fully 0014 Olivetol is found in certain species of lichens and herein. Similarly, the paper “Phytocannabinoids Beyond the can be readily extracted. Olivetol is also produced by a Cannabis Plant—do they exist?” Gertsch, Jürget al., BRITISH number of insects, either as a pheromone, repellent, or JoURNAL OF PHARMACOLOGY (2010) 160, 523-529, describes antiseptic. The Cannabis plant internally produces the other compounds which may interact directly or indirectly related substance olivetolic acid (OLA). Both Olivetol and with cannabinoid receptors, and which is hereby incorpo OLA can be synthesized in the laboratory. It has been rated by reference as if fully set forth herein. hypothesized that the Cannabis plant in turn utilizes OLA as 0010 While many psychoactive drugs clearly fall into the a component in its biosynthesis of THC. Further information category of either stimulant, depressant, or hallucinogen, and explanation of Olivetol and OLA are provided in the cannabis exhibits a mix of all properties, perhaps leaning the published paper, “In Vitro And In Vivo Pharmacology Of most towards hallucinogenic or psychedelic properties, Synthetic Olivetol-Or Resorcinol-Derived Cannabinoid though with other effects quite pronounced as well. THC is Receptor Ligands' M. G. Gascio et al., BRITISH JOURNAL OF typically considered the primary active component of the PHARMACOLOGY (October 2006) 149(4): 431-440, which is cannabis plant; various scientific studies have suggested that hereby incorporated by reference as though fully set forth certain other cannabinoids like CBD may also play a sig herein. Olivetol has been successfully used as a precursor in nificant role in its psychoactive effects. various laboratory syntheses of THC. However, literature 0011. In the early twentieth century, it became illegal in searches reveal no known uses of Olivetol for medicinal or most of the world to cultivate or possess Cannabis. How other human consumption purposes. ever, within the last decade, some states and nations have 0015. As such, there is a need for a way or compound that begun to legalize the cultivation, possession and use of can reduce, alleviate or inhibit the psychotropic effects of Cannabis for medical purposes. Cannabis is used to reduce cannabis after it has been consumed, or after it has been nausea and vomiting during chemotherapy, to improve appe consumed in a larger
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