Authors: Maria Doyle Ron Caspi James I Macrae An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Eleanor C Saunders Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. LeishCyc: Leishmania major strain Friedlin Cellular Overview Connections between pathways are omitted for legibility. Malcolm J Mcconville D-fructose D-fructose D-fructose hypoxanthine inosine 1-alkyl-2-acyl-phosphatidylcholine D-galactose D-galactose D-fructose D-galactose xanthine spermidine guanosine a phosphatidylcholine myo-inositol D-mannose D-mannose D-mannose D-mannose adenine arg arg putrescine D-glucose D-glucose D-glucose D-glucose guanine xanthosine

myo-inositol/ ABC polyamine glucose glucose hexose glucose nucleobase proton transporter transporter transporter transporter transporter transporter transporter AAP3 AAP3 NT2 symporter (ABCG4) (POT1) (GT3) (GT1) (GT4) (GT2) (NT3) (MIT)

1-alkyl-2-acyl-phosphatidylcholine inosine arg arg a phosphatidylcholine spermidine D-fructose D-fructose D-fructose D-fructose hypoxanthine guanosine putrescine myo-inositol D-galactose D-galactose D-mannose D-galactose xanthine xanthosine D-mannose D-mannose D-glucose D-mannose adenine D-glucose D-glucose D-glucose guanine

Fatty Acid and superpathway of sterol biosynthesis Lipid Degradation a [BCAA a [protein] N- Aminoacyl-tRNA Charging tRNA charging pathway fatty acid β-oxidation a purine carbonic acid 4,4-dimethyl-5-α-cholesta- Aldehyde Degradation dehydrogenase terminal-formyl- 4,4-dimethylzymosterol 4-methyl-2- 6 ribonucleoside leu 8,14,24-trien-3-β-ol E2 protein] N L-methionine phe a tRNA Phe coenzyme A oxopentanoate -lipoyl-L-lysine C-14 sterol glyoxalase pathway carbonic asp asp trp Trp lys Lys branched-chain tRNA a tRNA a tRNA reductase, peptide anhydrase- amino acid inosine- putative: G3IU-2308 long-chain-fatty- dihydroxyacetone D-glyceraldehyde- 2-oxoisovalerate deformylase, like protein: Ile Ala adenosine- ile a tRNA phenylalanyl- a tRNA ala aminotransferase, 4-α-methylzymosterol phosphate 3-phosphate dehydrogenase putative acid-coA ligase an acyl-CoA guanosine- G3IU-3847 vacuolar thr Thr asn Asn tRNA synthetase glt glu val Val his His aspartyl-tRNA gly Gly tryptophanyl- arg Arg met Met gln Gln lysyl-tRNA tyr Tyr leu Leu cys Cys ser ser putative: G3IU-3952 4,4-dimethylzymosterol beta subunit, (EMBL:AY353252) a tRNA tRNA a tRNA a tRNA a tRNA a tRNA a tRNA a tRNA a tRNA a tRNA a tRNA a tRNA a tRNA protein,putative: carbonic ATP alpha chain, synthetase, tRNA synthetase, synthetase, mitochondrial : G3IU-8117 nucleoside 4-methyl-2-oxopentanoate G3IU-3775 + + isoleucyl-tRNA putative: G3IU-2460 putative: G3IU-3237 putative: G3IU-3574 alanyl-tRNA putative: G3IU-6586 pro a tRNA Pro hydrolase, anhydrase H synthase H [+ 8 isozymes] precursor, polypeptide threonyl-tRNA synthetase, asparaginyl- phenylalanyl- glutamyl-tRNA valyl-tRNA histidyl-tRNA aspartyl-trna glycyl tRNA tryptophanyl- arginyl-tRNA synthetase, methionyl-tRNA glutaminyl-tRNA lysyl-tRNA tyrosyl-tRNA leucyl-tRNA cysteinyl-tRNA seryl-tRNA putative: family subunit D, methylglyoxal H + putative: deformylase- synthetase, putative: G3IU-149 trna synthetase, tRNA synthetase, synthetase, synthetase, synthetase, synthetase, synthetase, tRNA synthetase, synthetase, putative: G3IU-5205 synthetase, synthetase, synthetase, synthetase, synthetase, synthetase, synthetase, zymosterol G3IU-3293 protein, putative a 2,3,4-saturated G3IU-1271 like protein, putative: G3IU-1139 [+ 2 isozymes] putative: G3IU-1514 putative: G3IU-5831 putative: G3IU-2937 putative: G3IU-2949 putative: G3IU-3220 putative: G3IU-5472 putative: G3IU-332 putative: G3IU-5145 putative: G3IU-4026 [+ 2 isozymes] putative: G3IU-5495 putative: G3IU-6463 putative: G3IU-3271 putative: G3IU-6629 putative: G3IU-6830 putative: G3IU-7054 putative: G3IU-7207 a (3Z)-alk-3- putative: fatty acyl CoA 2-oxoisovalerate putative: G3IU-7886 vacuolar isovaleryl-CoA enoyl-CoA sterol 24-c- sterol 24-c- sterol 24-c- sterol 24-c- acyl-CoA dehydrogenase G3IU-2417 D-ribose ATP H + synthase H + Thr Ile Asn Phe Glu Val His asp Gly Trp Arg Ala Met Gln Lys Tyr Leu Cys ser Pro methyltransferase: methyltransferase: methyltransferase: methyltransferase: dehydrogenase, alpha subunit, a purine base an L-threonyl-[tRNA ] an L-isoleucyl-[tRNA ] an L-asparaginyl-[tRNA ] an L-phenylalanyl-[tRNA ] an L-glutamyl-[tRNA ] an L-valyl-[tRNA ] an L-histidyl-[tRNA ] an L-aspartyl-[tRNA ] a glycyl-[tRNA ] an L-tryptophanyl-[tRNA ] an L-arginyl-[tRNA ] an L-alanyl-[tRNA ] an L-methionyl-[elongator tRNA ] an L-glutaminyl-[tRNA ] an L-lysyl-[tRNA ] an L-tyrosyl-[tRNA ] an L-leucyl-[tRNA ] an L-cysteinyl-[tRNA ] an L-seryl-[tRNA ] an L-prolyl-[tRNA ] 3,2-trans- trypanothione SMT1.1 SMT1.2 SMT1.2 SMT1.2 putative: L-lactaldehyde putative: CO H O subunit c, isovaleryl-coA α β enoyl-CoA an N-terminal L- 2 2 5 -cholesta-7,24-dien-3 -ol hemithioacetal G3IU-5415 formate putative dehydrogenase, sterol 24-c- sterol 24-c- sterol 24-c- sterol 24-c- isomerase, G3IU-1008 methionyl-[protein] glyoxalase putative: G3IU-4068 methyltransferase: lathosterol methyltransferase: methyltransferase: methyltransferase: mitochondrial [+ 2 isozymes] P-type H+- acetyl-CoA i: GLO1 SMT1.2 oxidase-like SMT1.1 SMT1.1 SMT1.1 precursor- a [apo BCAA dehydrogenase H + ATPase, H + a 2-enoyl-CoA 6 Cofactor, Carrier, and Vitamin Biosynthesis 3-methylcrotonyl-CoA protein: G3IU-5023 like protein: S-lactoyl- E2 protein] N -S-[3- putative 24,24-dimethyl ergosta- G3IU-3579 trypanothione methylbutanoyl]dihydrolipoyl- fecosterol 7-dehydrodesmosterol 8,24(25)-ergostadienol 8,25(27)-ergostadienol methylcrotonoyl- 8,25(27)-dienol glyoxalase L-lysine folate metabolism [+ 2 isozymes] P-type H+- NAD biosynthesis molybdenum cofactor biosynthesis γ-glutamyl cycle pyridoxamine coa carboxylase II: G3IU- ubiquinone-9 biosynthesis acetoacetyl-CoA H + ATPase, H + II (from tryptophan) anabolism biotinylated 7057 a small subunit of a (2E)-2- CDP putative tetrahydrofolate all-trans- subunitprotein-like succinyl-CoA a 3-oxo acid a reduced N-acetyl- molybdopterin glutathione Secondary Metabolite Biosynthesis Other Biosynthesis enoyl-CoA xanthosine nonaprenyl pyridoxamine pyruvate protein: G3IU-2559 episterol Activation/Inactivation/Interconversion nitric oxide (R)-lactate tryparedoxin L-citrulline trp 4-hydroxybenzoate synthase diphosphate biosynthesis iron IAA biosynthesis I superpathway of (R,R)- 3-methylcrotonoyl- enoyl-CoA succinyl-coa:3- 2+ 2+ myo-inositol biosynthesis (R,R)-butanediol CoA carboxylase C-5 sterol homocysteine and cysteine interconversion hydratase/ a 2,3,4- D-lactate ribonucleoside- acetylornithine Fe transporter Fe butanediol biosynthesis ketoacid- N-formylkynurenine biosynthesis beta subunit, desaturase, arg isomerase- saturated (3R)-3- dehydrogenase- diphosphate deacetylase- inosine- (LIT1) a carboxy- coenzyme a formate- trp D-glucose 6-phosphate pyruvate putative: G3IU-7158 putative: G3IU-2821 like protein: hydroxyacyl-CoA like protein: reductase large like protein: adenosine- tetrahydrofolate 3-nonaprenyl-4- adenylated pyridoxal (R)-acetoin L-cystathionine transferase- guanosine- dihydrofolate myo-inositol- G3IU-3342 G3IU-3552 chain, putative: G3IU-2698 iron methionyl-trna ligase: FTL hydroxybenzoate [small subunit of glutathione broad specificity NADP-dependent 3-methylglutaconyl-CoA oxidoreductase- like protein: nucleoside reductase- 1-phosphate [+ 8 isozymes] d-lactate G3IU-3802 acetylornithine Fe 2+ transporter Fe 2+ pteridine cobalamin- formyltransferase, molybdopterin synthetase, pyridoxal aminotransferase: alcohol 5,7,24(28)-ergostatrienol like protein: G3IU-3075 hydrolase, thymidylate putative: G3IU-2316 kinase, synthase: INO1 cystathionine cystathione dehydrogenase- [+ 2 isozymes] deacetylase- (LIT1) reductase dependent kynurenine synthase] GTP putative: G3IU-1196 1D-myo-inositol (3) dehydrogenase, G3IU-5785 a 2,3,4- succinyl-coa:3- putative: synthase: α γ putative: beta-lyase, gamma like protein: like protein: 1: PTR1 methionine G3IU-6676 an -( -L- -monophosphate (S)-2-acetolactate putative: saturated (3S)-3- ketoacid- G3IU-3293 DHFR-TS L-γ- cysteinylglycine G3IU-3153 putative: lyase: G3IU-3953 G3IU-7785 dihydrofolate synthase: 2-nonaprenylphenol glutamyl)-L- indole-3-pyruvate G3IU-5139 hydroxyacyl-CoA coenzyme a dCDP pteridine glutamylcysteine myo-inositol-1 cystathionine G3IU-2276 G3IU-958 nitric oxide an oxidized reductase- G3IU-7803 amino acid (S)-3-hydroxy-3-methylglutaryl-CoA L-citrulline transferase- reductase: a thiocarboxylated pyridoxal-P phosphatase, alcohol 5,7,22,24(28)-ergostatetraenol beta-synthase: trifunctional tryparedoxin thymidylate [small subunit of dehydrogenase, CYSB cystathionine enzyme pyruvate a quinol like protein: D-ribose xanthine all folates PTR1 serine 3-hydroxy- cyclic pyranopterin putative: acetate L-citrulline synthase: molybdopterin putative putative: sterol C-24 beta-lyase- alpha subunit, G3IU-3076 hydroxymethyltransferase: L-kynurenine monophosphate gamma- G3IU-6523 3-hydroxy-3- cys citrate degradation DHFR-TS 2-nonaprenyl-6- synthase] pyruvate/ diacetyl (R)-acetoin G3IU-3057 reductase, like protein: mitochondrial SHMT-L 10-formyl- glutamylcysteine myo-inositol-1(or 4)- (R,R)-2,3- methylglutaryl-CoA 7,8-dihydrofolate kynureninase, hydroxyphenol cys gly indole- putative: G3IU-2047 G3IU-6723 precursor- serine tetrahydrofolate synthetase: tryptamine monophosphatase 1, butanediol reductase: HMGR a 2,3,4-saturated putative: molybdopterin pyridine nucleotide cycling (plants) pyruvate NADP-dependent like protein: citrate succinate hydroxymethyltransferase: G3IU-5942 putative: G3IU-6120 acetoacetate ergosterol 3-oxoacyl-CoA G3IU-4262 synthase carboxylase, alcohol G3IU-4333 SHMT-S L-homocysteine methylene THF sulphurylase- coenzyme A putative: myo-inositol dehydrogenase, (R)-mevalonate pteridine 5-methyl- 3-hydroxyanthranilate nicotinate mononucleotide [+ 6 isozymes] citrate synthase, cyclohydrolase/ 2-nonaprenyl-6- like protein, biosynthesis G3IU-1417 putative: α UDP reductase tetrahydrofolate a 2,3,4-saturated putative: G3IU-6042 a [protein]- -D-Man-(1->2)- a reduced a ubiquitin C- a ribonucleoside methylene THF methoxyphenol putative: N-hydroxyl- G3IU-5139 mevalonate kinase, α 1: PTR1 glt 5-oxoproline triacylglycerol 3-oxoacyl-CoA citrate synthase, L-asparagine -D-Man-(1->2)- tryparedoxin terminal thioester diphosphate dehydrogenase: G3IU-3991 (R)-pantothenate tryptamine alcohol putative: G3IU-2824 α nucleoside dihydrofolate degradation putative: G3IU-6043 -D-Man-(1->3)- DHCH1 nicotinate pantothenate dehydrogenase, putative 3- α diphosphate reductase- aminocarboxymuconate Fermentation [ -D-Man-(1->2)- phosphoribosyltransferase, kinase subunit, putative: mevalonate-5-phosphate ketoacyl- α kinase, thymidylate semialdehyde 2-nonaprenyl- molybdopterin a triacyl-sn-glycerol -D-Man-(1->3)- ribonucleoside- cysteine putative: G3IU-2005 putative: G3IU-3057 CoA acetyl-CoA oxaloacetate α putative: synthase: 6-methoxy-1,4- phosphomevalonate (R)-acetoin lipase domain -D-Man-(1->6)]- diphosphate peptidase, methylenetetrahydrofolate G3IU-3881 indole-3- thiolase- β β G3IU-894 DHFR-TS benzoquinone D-4'- (R,R)-2,3- (R)-acetoin protein, -D-Man-(1->4)- - reductase large Clan CA, reductase: MTHFR nicotinate riboside nicotinate adenine dinucleotide acetaldoxime kinase-like biosynthesis I like 5-oxoprolinase: phosphopantothenate indole-3-glycerol- butanediol protein: G3IU-6461 biosynthesis II putative: D-GlcNAc-(1->4) chain, putative: family C19, nucleoside protein: -α-D-GlcNAc- G3IU-3802 G3IU-6008 phosphate pyruvate G3IU-3447 STT3, putative: diphosphate quinolinate molybdopterin- pyruvate G3IU-2716 diphosphodolichol 2-nonaprenyl- mevalonate-diphosphate [+ 3 isozymes] Detoxification a dolichyl putative: [+ 2 isozymes] G3IU-1333 kinase b: AMP NAD+ synthase, [+ 2 isozymes] 3-methyl-6- indole-3- a diglyceride diphosphate G3IU-1166 [+ 5 isozymes] nucleoside putative: G3IU-2378 R-4'- diphosphomevalonate methoxy-1,4- acetonitrile acetyl-CoA superoxide diphosphate 5,10- 5,10- phosphopantothenoyl- indole decarboxylase, (S)-2-acetolactate [+ 3 isozymes] dUDP an oxidized benzoquinone L-cysteine indole-3-acetamide indole (S)-2-acetolactate radicals kinase b methylene-THF methenyltetrahydrofolate nicotinate acetaldehyde nitrilase, putative: G3IU-6110 tryparedoxin a thiol a ribonucleoside molybdenum nicotinate NAD + degradation a ubiquitin mononucleotide cofactor putative: triphosphate G3IU-4258 isopentenyl diphosphate a 2-acylglycerol superoxide β diacetyl fatty acid -oxidation IV (unsaturated, even number) iron a protein with an 3-demethylubiquinol-9 4'-phosphopantetheine (R)-acetoin NAD/NADH phosphorylation polyphosphate metabolism isomerase, superoxide N-linked glycan nicotinate adenine indole-3-acetate putative: G3IU-749 dismutase: and dephosphorylation dinucleotide 3-demethylubiquinone- a (2E,4Z)-2,4-dienoyl-CoA 9 3-methyltransferase, SODA NAD+ long chain Polyprenyl Biosynthesis a 1-monoglyceride 2 NAD + putative: G3IU-854 dimethylallyl diphosphate 2,4-dienoyl- iron an [eIF5A- sn-glycerol- trans-∆ - synthase, nicotinamide nicotinamide mononucleotide polyphosphate spermidine detyrosinated methylenetetrahydrofolate (R)-acetoin monoglyceride coa reductase- superoxide precursor]-lysine α tyr 3-phosphate decenoyl-CoA putative: ubiquinol-9 dephospho-CoA farnesyl diphosphate -tubulin 2,4-dienoyl- dehydrogenase: G3IU-5323 inosine-adenosine- polyisoprenoid biosynthesis (E. coli) lipase, putative: like protein: dismutase: glycerol-3- NADH-ubiquinone ATP-NAD G3IU-2378 synthase: FPPS coa methylene THF guanosine- dephospho- acidocalcisomal G3IU-2766 G3IU-7853 SODB1 deoxyhypusine phosphate oxidoreductase kinase-like biopterin metabolism isopentenyl prenyltransferase, reductase- NAD + nucleoside hydrolase, CoA kinase, exopolyphosphatase, 2,4-dienoyl- iron tubulin- dehydrogenase 20 kDa subunit, protein: cyclohydrolase/ diphosphate putative: G3IU-3757 glycerol synthase, like protein: putative: G3IU-3293 putative: putative: G3IU-8486 CoA reductase superoxide tyrsoine [FAD], mitochondrial G3IU-7901 methylene THF quinonoid- folate polyglutamylation I putative: G3IU-7853 quinonoid G3IU-5206 isomerase, fadh1, putative: dismutase: ligase-like mitochondrial: precursor: NADH- dehydrogenasease, dihydropteridine geranyl diphosphate G3IU-1723 cytoplasmic, dihydrobiopterin reductase: QDPR-7 putative: G3IU-2019 SODC protein: FAD-GPDH 2,4-dienoyl- ubiquinone + nicotinamide riboside ascorbate biosynthesis coenzyme A deoxyhypusine NADP tetrahydrofolate long chain G3IU-749 G3IU-7177 glycerol-3- CoA oxidoreductase putative: DHCH1 quinonoid- prenyltransferase, a cis-2-enoyl-CoA hydrogen[+ 2 isozymes] synthase, polyphosphate a (3E)-3-enoyl-CoA [+ 7 isozymes] phosphate reductase 20 kDa subunit, dihydropteridine dimethylallyl putative: G3IU-3757 peroxide putative: D-glucuronate dehydrogenase- fadh1, mitochondrial reductase: QDPR-6 formate- serine diphosphate farnesyl diphosphate enoyl-CoA 3,2-trans-enoyl- G3IU-5739 like protein: putative: precursor quinonoid- tetrahydrofolate hydroxymethyltransferase: glucuronate farnesyl synthase: FPPS hydratase/ CoA isomerase, a 7,8- enoyl-CoA α G3IU-5717 G3IU-2019 ligase: FTL SHMT-L isomerase- -tubulin ∆ 2 ∆ 4 dihydropteridine dihydrobiopterin reductase: diphosphate hydratase/ mitochondrial propane- an [eIF5A- dihydroxyacetone trans- , cis- - [+ 2 isozymes] serine a tetrahydrofolate (2E,6E)-farnesyl diphosphate like protein: reductase: QDPR-5 G3IU-3912 synthase: isomerase- precursor- O 1,3-diamine precursor]- phosphate decadienoyl-CoA pterin-4α- 10-formyl- hydroxymethyltransferase: FPPS G3IU-3342 like protein: 2 deoxyhypusine quinonoid- pteridine folylpolyglutamate L-gulonate farnesyltransferase, like protein: NADH carbinolamine tetrahydrofolate SHMT-S [+ 8 isozymes] G3IU-3579 dihydropteridine reductase synthetase: FPGS D-arabinose prenyltransferase, putative: G3IU-2580 Respiration G3IU-3342 dehydratase: pteridine aerobic respiration -- electron donor a 2,3,4-saturated (3R reductase: QDPR-4 1: PTR1 gulonolactonase, dehydro-erythro putative: G3IU-3757 [+ 8 isozymes] [+ 2 isozymes] a pyrimidine base a (2E)-2- biopterin G3IU-7195 reductase 5,10- a tetrahydrofolate D-arabinose )-3-hydroxyacyl-CoA (2E,6E)-farnesyl a [protein]- H O quinonoid- putative: G3IU-3766 -ascorbate 2 methylene-THF geranyl presqualene diphosphate a (2E)-2-enoyl-CoA diphosphate GTP lesion in DNA enoyl-CoA biopterin transporter biopterin 4α-hydroxy- 1: PTR1 10 dehydrogenase: NADH L-cysteine 2,4-dienoyl- a tetrahydrobiopterindihydropteridine NADPH biopterin an N - L-gulono- diphosphate apurinic/ (BT1) tetrahydrobiopterin putative L-dehydro- PGFS coa NADPH reductase: QDPR-3 formyltetrahydrofolate 1,4-lactone dehydroascorbate prenyltransferase, farnesyltransferase, apyrimidinic phenylalanine- ascorbate D-arabino- ascorbate reductase- [+ 2 isozymes] folylpolyglutamate dehydroascorbategulono-1,4- arabino- reductase: TDR1 putative: G3IU-3757 putative: G3IU-2580 enoyl-CoA protein GTP-ase endonuclease- trypanothione redox reactions 4-hydroxylase, reductase: TDR1 1,5-lactone peroxidase: UQ hydratase/ farnesyltransferase redox protein: like protein: putative: synthetase: FPGS a 5,10- lactone 1,4- farnesyl activating APX squalene isomerase- alpha subunit, apurinic/ G3IU-7853 10 methylenetetrahydrofolate oxidase: lactone protein, G3IU-3761 an N - diphosphate like protein: putative: G3IU-3378 apyrimidinic trypanothione a reduced folylpolyglutamate G3IU-6124 oxidase: synthase: putative: 2,4-dienoyl- formyltetrahydrofolate dehydro-D- squalene G3IU-3342 endonuclease- disulfide tryparedoxin ovothiol A synthetase: FPGS ascorbate L-ascorbate- L-xylo- D-arabinono- G3IU-6124 FPPS farnesyltransferase G3IU-1250 CoA monodehydroascorbate arabinono- monooxygenase-like redox protein biosynthesis peroxidase: 6-phosphate hexulonolactone 1,4-lactone [+ 8 isozymes] beta subunit: [+ 5 isozymes] reductase a 5,10- 1,4-lactone (2E,6E)-farnesyl protein: G3IU-6778 glutathione phe APX farnesyltransferase endonuclease fadh1, methylenetetrahydrofolate diphosphate a 2,3,4-saturated (3S redox cys (S)-2,3-epoxysqualene beta subunit GDP III, putative: putative: reactions I pyridoxal 5'-phosphate salvage pathway )-3-hydroxyacyl-CoA phosphate G3IU-7534 G3IU-2019 tryparedoxin cis- solanesyl- lanosterol an apyrimidinic a (2E,4E)-2,4- trypanothione glutathione a [protein]-S- peroxidase: S-4-(histidyl)- prenyltransferase- diphosphate synthase: ERG7 site in DNA dienoyl-CoA reductase: disulfide pyridoxamine farnesyl-L-cysteine G3IU-5173 cysteine sulfoxide like protein: synthase: TRYR Alcohol Degradation [+ 7 isozymes] pyridoxine pyridoxal G3IU-6938 G3IU-6509 lanosterol glycerol metabolism glutathione kinase, a 3-oxo- di-trans,poly-cis all-trans- acetoacetate succinyl-CoA a sphingomyelin a nucleoside peroxidase, putative: pyrimidine ribonucleotides Nucleoside and Nucleotide Biosynthesis α a glycerophosphodiester RNA 5α-steroid pyridoxal purine nucleotide metabolism pyrimidine deoxyribonucleotides de novo biosynthesis I -undecaprenyl octaprenyl lanosterol 14 - triphosphate putative: G3IU-3153 de novo biosynthesis salvage pathways of pyrimidine 3-oxo-5-alpha- mercaptohistidine (phosphotransfer and nucleotide modification) diphosphate diphosphate demethylase: ERG11 G3IU-419 deoxyribonucleotides steroid 4- pyridoxine- pyridoxamine CDP glycerophosphoryl succinyl-coa:3- neutral an oxidized [+ 3 isozymes] pyridoxal bicarbonate deoxycytidine α DNA- dehydrogenase, trypanothione 5'-phosphate 5'-phosphate 4,4-dimethyl-5- -cholesta- diester ketoacid-coenzyme sphingomyelinase tryparedoxin kinase, inosine-5'- ribonucleoside-diphosphate β formate directed RNA putative: EnCR carbamoyl- 8,14,24-trien-3- -ol phosphodiesterase, a transferase-like activation putative: phosphate reductase small chain, polymerase 3-oxo-5-alpha- phosphate putative: G3IU-114 glycerol protein: G3IU-3075 associated factor- ovothiol A G3IU-3153 putative: G3IU-3950 I-like protein: steroid 4- glutathione synthase, like protein: [+ 2 isozymes] deoxyuridine glycerophosphoryl succinyl-coa:3- G3IU-3566 dehydrogenase- putative: G3IU-4982 inosine-5'- adenylosuccinate diester glycerol kinase, ketoacid-coenzyme like protein: pyridoxal-P G3IU-6386 dCDP [+ 9 isozymes] monophosphate synthetase, UDP thymidine phosphodiesterase, glycosomal, a transferase-like G3IU-6151 carbamoyl- dehydrogenase: putative: G3IU-6821 kinase, putative: G3IU-3678 putative: G3IU-973 protein: G3IU-3076 phosphoryl- a sphingosine- a 3-oxo- nucleoside diphosphate ∆ 4 phosphate inosine-5'- putative: deoxyribose choline containing RNA -steroid kinase, putative: G3IU-894 + ceramide aspartate monophosphate G3IU-5438 1-phosphate NAD adenylo-succinate nucleoside diphosphate CTP dUDP sn-glycerol-3-phosphate acetoacetyl-CoA succinate carbamoyltransferase, dehydrogenase ethanol degradation kinase b: nucleoside dUMP putative: G3IU-6392 inosine-5'- adenylosuccinate II (cytosol) diphosphate kinase b nucleoside diphosphate glycerol-3-phosphate Amine and Polyamine Biosynthesis monophosphate lyase, putative: O a reduced c- succinate glycerol-3-phosphate 2 dehydrogenase-like β α N-carbamoyl- G3IU-8154 kinase, putative: G3IU-894 thymidine type cytochrome a (1->2)- - GDP- -D- L-aspartate dehydrogenase: dCTP UTP protein: G3IU-5717 dehydrogenase ethanol D-mannan mannose a ubiquitin N-acetyl-L- a protein G3IU-6183 nucleoside diphosphate thymidine [NAD+], glycosomal/ NADP-dependent a [protein]-L-lysine ornithine UDP-N-acetylglucosamine AMP glycerol-3-phosphate oligosaccharide superpathway of polyamine biosynthesis I trypanothione dihydroorotase, kinase b: nucleoside kinase, mitochondrial: GPD alcohol dehydrogenase, biosynthesis dehydrogenase biosynthesis putative: adenylate diphosphate kinase b putative: putative: G3IU-5139 [FAD], mitochondrial: β D-fructose- G3IU-6387 xanthosine- kinase: G3IU-5438 -1,2- ubiquitin- acetylornithine proteasome 6-phosphate arg pyrimidine nucleotide dUTP FAD-GPDH alcohol dehydrogenase, glucosamine- glutathionylspermidine 5-phosphate G3IU-591 mannooligosaccharide protein ligase- deacetylase- beta 2 subunit, SAM (S)-dihydroorotate metabolism dTMP putative: G3IU-3057 fructose-6- trypanothione dUTP diphosphatase: acetaldehyde synthase: MPT1 like, putative: like protein: putative: [+ 5 isozymes] (phosphotransfer dihydroxyacetone phosphate phosphate synthetase: TRYS glutamine G3IU-7891 β-1,2- G3IU-7784 G3IU-2698 G3IU-697 S-adenosylmethionine and nucleotide aminotransferase, [+ 2 isozymes] amidotransferase, ADP aldehyde mannooligosaccharide [+ 18 isozymes] [+ 6 isozymes] [+ 7 isozymes] decarboxylase: trypanothione modification) dUMP NADH-ubiquinone putative: G3IU-7851 L-ornithine putative: G3IU-5346 UMP dehydrogenase, synthase: MPT2 D-glucosamine agmatine ADOMETDC ribonucleoside- pteridine reductase 1: PTR1 oxidoreductase putative: G3IU-195 lys orotate 20 kDa subunit, a [protein]-N 6 - 6-phosphate S-adenosylmethionine GMP diphosphate cytochrome c metallo- [+ 3 isozymes] β acetate Peptide Peptide dihydrofolate mitochondrial a (1->2)- - monoubiquitinyl-L-lysine L-ornithine glucosamine- decarboxylase reductase large UDP oxidase VIII peptidase, GDP agmatinase- ornithine reductase-thymidylate precursor: NADH- D-mannan phosphate N- proenzyme-like, 5-phospho- chain, putative: (COX VIII) Clan ME, acetate like protein: decarboxylase: guanylate synthase: DHFR-TS ubiquinone oligosaccharide acetyltransferase: putative: G3IU-2950 α-D-ribose 1- G3IU-3802 , putative: Family M16: succinate G3IU-5170 ODC kinase, dTMP oxidoreductase acetyl-CoA synthetase, GNAT diphosphate [+ 2 isozymes] G3IU-2722 G3IU-1142 dehydrogenase, cadaverineS-adenosyl-L-methioninamine putative: UTP 20 kDa subunit, putative: G3IU-5121 N-acetyl-D- thymidylate kinase- putative: + a reduced α OMPDCase- G3IU-1991 [+ 9 isozymes] [+ 2 isozymes] mitochondrial acetyl-CoA synthetase, a DNA containing an apurinic/apyrimidinic site NADP a myosin heavy chain -D-glucose glucosamine putrescine 2'-deoxyadenosine- CTP like protein: G3IU-7364 G3IU-6512 flavodoxin OPRTase, precursor putative: G3IU-5093 aldose 1- 6-phosphate putative: GDP 5'-diphosphate synthase, succinate myosin heavy N-acetylglucosamine- dTDP epimerase, spermidine glutathionylspermidine G3IU-6391 putative: [+ 2 isozymes] dehydrogenase acetyl-CoA apurinic/apyrimidinic chain kinase phosphate mutase, ferredoxin putative: synthase, biosynthesis nucleoside G3IU-5704 nucleoside diphosphate flavoprotein, endonuclease-redox a-like protein: putative: G3IU-7725 orotidine-5'- nucleoside ribonucleoside- NADP+ G3IU-1181 putative: diphosphate diphosphate CTP kinase, putative: G3IU-894 salvage pathways of purine nucleosides putative: protein: apurinic/ G3IU-244 N-acetyl- glutathione spermidine phosphate diphosphate diphosphate reductase- aldose 1- G3IU-8142 kinase, nucleoside diphosphate G3IU-4813 apyrimidinic endonuclease- myosin heavy glucosamine- kinase, reductase large nucleoside like protein: epimerase- putative: kinase b: nucleoside redox protein chain kinase 1-phosphate OMPDCase- putative: chain, putative: diphosphate Carboxylate Degradation G3IU-5536 like protein: trypanothione G3IU-894 diphosphate kinase b adenosine guanosine c-like protein: UDP-N- aminopropylcadaverine spermidine S-methyl-5'-thioadenosine OPRTase, G3IU-894 G3IU-3802 kinase, endonuclease III, G3IU-5132 synthetase: TRYS G3IU-4672 acetylglucosamine putative: nucleoside putative: dTTP putative: G3IU-7534 nucleoside [+ 2 isozymes] nonspecific acetyl-CoA biosynthesis (from pyruvate) NADPH an oxidized H + myosin-heavy β-D-glucose pyrophosphorylase, G3IU-6391 diphosphate diphosphate G3IU-894 nucleoside flavodoxin chain-phosphate putative: G3IU-1844 kinase b: adenosine nonspecific an oxidized c- a [pyruvate glutathionylspermidine UMP kinase b: nucleoside hydrolase: NH H O fumarate UDP-α-N-acetyl- nucleoside deaminase- nucleoside 2 type cytochrome dehydrogenase a 3'-terminal unsaturated sugar a 5'-phosphopolynucleotide nucleoside 2'-deoxyguanosine- diphosphate adenosine D-glucosamine diphosphate like protein: hydrolase: NH inosine- E2 protein] N 6 diphosphate 5'-diphosphate kinase b: kinase: AK pyruvate kinase b G3IU-2109 inosine- nucleoside adenosine- -lipoyl-L-lysine kinase b nucleoside [+ 2 isozymes] sn-glycerol- dehydrogenase adenosine adenosine- phosphorylase- guanosine- dihydrolipoamide a tRNA an [RNA]-3'- UDP nucleoside diphosphate 3-phosphate complex: G3IU- queuine Peptide an alcohol dATP deaminase, guanosine- like protein: nucleoside dehydrogenase: containing ribonucleoside- Tetrapyrrole Biosynthesis diphosphate kinase b 4563 E1α kinase, putative: nucleoside G3IU-7260 hydrolase, GCVL guanine alcohol 3'-phosphateRNA 3'- GTP putative: dehydrogenase, putative: CDP G3IU-1064 hydrolase, adenine dihydrolipoamide metallo- terminal heme biosynthesis AMP G3IU-3293 putative: UTP G3IU-894 putative: phosphoribosyltransferase: dehydrogenase: queuine tRNA- peptidase, phosphate G3IU-3293 a [pyruvate a [pyruvate G3IU-3057 CTP nucleoside APRT G3IU-3390 methylmalonyl pathway ribosyltransferase, Clan MF, cyclase, guanine dehydrogenase dehydrogenase NADP-dependent nucleobase coproporphyrinogen III synthase, diphosphate inosine amp putative: G3IU-3087 Family M17: putative: coproporphyrinogen deaminase- E2 protein] N 6 E2 protein] N 6 -S- alcohol G3IU-1111 adenine transporter adenine putative: kinase b: propanoyl-CoA G3IU-5069 an [RNA]-3'- iii oxidase, like protein: -dihydrolipoyl- acetyldihydrolipoyl- a tRNA dehydrogenase, (NT4) G3IU-5704 nucleoside adenine propionyl-CoA ribonucleoside- putative: G3IU-7817 G3IU-6842 L-lysine L-lysine containing putative: diphosphate nonspecific guanine xanthine glycerol-3- carboxylase beta guanine 2',3'- protoporphyrinogen IX CTP GUN anticodon a proteinogenic G3IU-5139 kinase b nucleoside [+ 3 isozymes] deaminase, phosphoribosyltransferase: phosphate chain, putative: Peptide cyclophosphate with quenosine amino acid an aldehyde protoporphyrinogen nucleoside hydrolase: NH putative: XPRT dehydrogenase- G3IU-3845 at position 34 or ketone oxidase-like diphosphate dGTP inosine- G3IU-3492 hypoxanthine-guanine like protein: dihydrolipoamide (S)-methylmalonyl-CoA salvage pathways of pyrimidine ribonucleotides protein: G3IU-7816 kinase, adenosine- phosphoribosyltransferase: G3IU-5717 acetyltransferase putative: guanosine- HGPRT glycerol-3- precursor, methylmalonyl-coa a 1-phosphatidyl- (5z,13e)-(15s) D-myo-inositol cytidine xanthine xanthine respiration (anaerobic) a ferrocytochrome protoporphyrin IX G3IU-894 nucleoside phosphate putative: G3IU-456 epimerase-like stearoyl-CoA 1D-myo-inositol -9-α,11-α,15- (1,4,5)- phosphoribosyltransferase: b xanthine protein: G3IU-4484 5 trisphosphate nucleoside XPRT hydrolase, dehydrogenase dihydrolipoamide 4-phosphatephosphatidylinositol- trihydroxyprosta- inositol-1,4,5- ferrochelatase-like phosphoribosyltransferase: 2-phospho-D-glycerate prostaglandin diphosphate cytosine putative: GMP [FAD], acetyltransferase (R)-methylmalonyl-CoA 4-phosphate 5,13-dienoate trisphosphate protein: G3IU-6113 hypoxanthine-guanine XPRT f2-alpha kinase b: inosine-5'- phosphoribosyltransferase: G3IU-3293 mitochondrial: precursorlike fatty-acid 5-kinase-like, (IP3) 5- uridine CMP methylmalonyl- synthase: PGFS protoheme IX nucleoside phosphate HGPRT enolase: ENOL FAD-GPDH protein: G3IU-5523 desaturase, putative: G3IU-1222 phosphatase, diphosphate xanthosine- coenzyme a mutase, putative: prostaglandin phosphatidylinositol- putative: kinase b 5-phosphate putative: G3IU-4132 G3IU-4750 f synthase, hypoxanthine phosphoenolpyruvate 4-phosphate-5- D-myo- G3IU-7115 [+ 2 isozymes] putative: CDP uridine kinase-like CDP pro succinyl-CoA kinase-likep ro (5z,13e)-(15s)-9- inositol (1,4)- uracil protein: G3IU-2631 G3IU-2505 bisphosphate uracil nucleoside diphosphate a 1-phosphatidyl-tein: G3IU-1433 α,15-dihydroxy- pyruvate kinase, UQH proline 2 a ferricytochrome oleoyl-CoA 1D-myo-inositol 11-oxoprosta- phosphoribosyltransferase, kinase, putative: G3IU-894 putative: G3IU-1274 oxidase: b 4,5-bisphosphate 5,13-dienoate putative: G3IU-1649 nucleoside diphosphate pyruvate kinase, G3IU-4327 5 oxaloacetate UMP kinase b: nucleoside putative: G3IU-1273 dihydroxyacetone (S)-1-pyrroline- diphosphate kinase b mitochondrial malate phosphate 5-carboxylate a reduced peptide-L- D-ribose 5- a [protein]- NADP + CTP pyruvate dehydrogenase: mMDH ferredoxin [iron- TsnC methionine phosphate uracil L-tyrosine sulfur] cluster phosphate [+ 3 isozymes] tyrosine Carbohydrate Biosynthesis pyruvate dehydrogenase (S)-malate Inorganic Nutrient Metabolism ferredoxin pseudouridylate phosphatase methionine- isoform, lipophosphoglycan (LPG) biosynthesis Fatty Acid and Lipid Biosynthesis multienzyme complex: NADP+ synthase- dolichol S-sulfoxide putative: superpathway of phospholipid biosynthesis dolichyl-diphosphooligosaccharide biosynthesis G3IU-5523 G3IU-456 mitochondrial fumarate nitrate reductase- like protein: biosynthesis formate hydratase: FHm urea cycle reductase: G3IU-8489 G3IU-1607 a 1-phosphatidyl- G3IU-3390 GCVL reduction II like protein: G3IU-7689 dihydroxyacetone GDP-arabinose α [+ 12 isozymes] 1D-myo-inositol dehydrodolichol a phosphatidate E1 G3IU-4563 (assimilatory) G3IU-5536 [+ 4 isozymes] phosphate a dolichyl phosphate biosynthesis fumarate a [protein]- phosphatidylinositolN- diphosphate arg peptide-L- L-tyrosine phosphatidate nitrate an oxidized acetylglucosaminyltransfe D-glucose + methionine pseudouridine glycerol-3- cytidylyltransferase- acetyl-CoA nitrate NADPH ferredoxin [iron- H a thioredoxin ra sesubunit c, UDP-N-acetylglucosamine- dolicholphosphate- CO reductase, (S)-S-oxide 5'-phosphate a dolichol phosphate a 1-acyl-glycerone like protein: 2 sulfur] cluster putative: G3IU-554 -dolichyl-phosphate N- mannose citrate synthase, 2-ketoglutarate dehydrogenase complex arginase, dehydrogenase 3-phosphate G3IU-2253 putative: ammonia n-acetylglucosaminyl- acetylglucosaminephosphotransferase: synthase: DPMS a dolichyl β-D- D-arabinose putative: G3IU-6042 succinate G3IU-3222 putative: [NAD+], alkyldihydroxyacetonephosphate cdp- a [2-oxoglutarate G3IU-1132 phosphatidylinositolbiosyn glycosomal/ ALG7 glucosyl phosphate citrate synthase, dehydrogenase nitrite carbamoyl- a di-trans, poly- a [protein]-L- synthase: ADS1 diacylglycerol β fucose isopentenyl ATP a dolichyl -D- putative: G3IU-6043 6 an N-acylated amino acid cis-polyisoprenyl ω th eticprotein, mitochondrial: E2 protein] N 2-oxoglutarate phosphate diphosphate proline ( = 180) a 1-alkyl- synthetase- N-acetyl-α-D-glucosaminyl- mannosyl phosphate (arabinose) L-arginino- diphosphate cyclophilin receptor-type putative: G3IU-1930 GPD citrate -lipoyl-L-lysine dehydrogenase L-ornithinesynthase, a 6-(N-acetyl-α- glycerone 3- like protein: diphosphodolichol kinase: succinate putative: type peptidyl- adenylate G3IU-4326 G3IU-6402 dihydrolipoamide subunit, putative: D-glucosaminyl)- phosphate dihydroxyacetone G3IU-6386 n-acyl-l-amino acid dehydrodolichol- prolyl cyclase a- sn-glycerol- aconitase, putative: dehydrogenase: G3IU-4073 ammonia 1-phosphatidyl- phosphate a CDP- fucose amidohydrolase, diphosphate cis-trans like protein: 3-phosphate G3IU-6061 GCVL [+ 2 isozymes] carbamoyl- 1D-myo-inositol acyltransferase: DAT diacylglycerol N-acetyl-β-D-glucosaminyl- gluconeogenesis I (arabinose) putative: G3IU-2767 synthase: isomerase, G3IU-402 N-acetyl-D- dihydrolipoamide glutamine argininosuccinate phosphate a 1-alkyl-sn (1->4)-N-acetyl- kinase: cis-aconitate [+ 4 isozymes] G3IU-6938 putative: [+ 8 isozymes] glucosaminylphosphatidylinositol glycerol-3- G3IU-6398 dehydrogenase: synthetase, synthase, putative: -glycerol 3- phosphatidylglycerophosphate phosphatidyltransferase, α-D-glucosaminyl- a [2-oxoglutarate a [2-oxoglutarate α G3IU-5164 cyclic-AMP deacetylase: GPI12 phosphate (S)-malate G3IU-3390 branched-chain -keto acid dehydrogenase complex putative: G3IU-5149 α phosphate synthase-like protein: G3IU-7792 putative: G3IU-4237 diphosphodolichol D-arabinose aconitase, putative: dehydrogenase dehydrogenase a di-trans, poly- [+ 19 isozymes] 6-( -D- acyltransferase: G3IU-7912 L-citrulline a [protein]-L- 5-phosphate G3IU-6061 E2 protein] N 6 E2 protein] N 6 -S- a [BCAA dehydrogenase2-oxoisovalerate a carboxylate cis-polyisoprenyl glucosaminyl)- choline ethanolamine GAT mitochondrial an L-amino acid ω a 1-phosphatidyl- ALG1: ALG1 6 proline ( = 0) 1-phosphatidyl- malate -dihydrolipoyl- succinyldihydrolipoyl- E2 protein] dehydrogenaseN gln diphosphate a phosphatidylglycerophosphate 1D-myo-inositol D-threo-isocitrate beta subunit, 1D-myo-inositol 1-alkyl-2-acyl- β-D-Man-(1->4)-β-D- dehydrogenase: L-lysine L-lysine -lipoyl-L-lysine mitochondrial GPI14: a 2-lysophosphatidate glycerol-3- GlcNAc-(1->4)-α-D- malic mMDH isocitrate dehydrogenase, triacylglycerol biosynthesis precursor, Carbohydrate Degradation an all-trans- methylcob(III) a protein GPI14 phosphate GlcNAc-diphosphodolichol enzyme, [+ 3 isozymes] GDP-D-arabinose putative: G3IU-1841 isopentenyl phosphoryl- phosphoryl- 1-acyl-sn-glycerol-3- putative: putative: TsnC met polyisoprenyl alamin-[methionine with incorrect mannose-α-1- diphosphate choline ethanolamine phosphateacyltransferase- ALG2: ALG2 G3IU-4901 isocitrate dehydrogenase 2-oxoglutarate G3IU-1271 diphosphate synthase]methionine disulfide bondsprotein 4-glucosaminyl- a phosphatidylglycerol sn-glycerol-3-phosphate oxaloacetate sucrose degradation III cholinephosphate ethanolamine- l ik eprotein, [NADP], mitochondrial dehydrogenase, synthase disulfide phosphoinositol α β dihydrolipoamide 2-oxoisovalerate cytidylyltransferase phosphate putative: G3IU-2347 1-alkyl-2- glycerol-3-phosphate -D-Man-(1->3)- -D- precursor, putative: E2 component, methionine- solanesyl- reductase, isomerase: Man-(1->4)-β-D-GlcNAc- phosphoenolpyruvate G3IU-7337 dihydrolipoamide dehydrogenase: dehydrogenase sucrose A, putative: G3IU-5976 cytidylyltransferase, acyl-glycerol cardiolipin acyltransferase: GAT PRPP biosynthesis I beta- S-sulfoxide diphosphate mitochondrial PDI-2 a phosphatidate (1->4)-α-D-GlcNAc- carboxykinase: GDP-L-fucose succinyltransferase, GCVL alpha subunit, putative: G3IU-2458 synthetase, a 2-lysophosphatidate fructofuranosidase- reductase: synthase: precursor- [+ 2 isozymes] CDP-choline diphosphodolichol G3IU-3976 biosynthesis II 2-oxoglutarate putative: G3IU-3645 dihydrolipoamide putative: a protein mannose-α-1- putative: pyruvate D-ribose 5- like protein: G3IU-7689 G3IU-6509 like protein: CDP-ethanolamine phosphatidic 1-acyl-sn-glycerol-3- (from L-fucose) an [apo BCAAdehydrogenase: G3IU-5415an [apo BCAA dehydrogenase with correct 3-mannose-α-1- G3IU-1538 phosphoenolpyruvate phosphate G3IU-1214 G3IU-242 acid phosphateacyltransferase- ALG2: ALG2 phosphoribosylpyrophosphate dehydrogenaseG3IU-3390 E2 protein] N 6 -S-[2- cob(I)alamin- disulfide bonds 4-glucosaminyl- UDP-D-galacto- 1-alkyl-2-acyl- 1-alkyl-2-acyl- 1-alkyl-2-acyl- 1-alkyl-2-acyl- carboxykinase: L-fucose an all-trans- phosphatase l ik eprotein, synthetase, putative: G3IU-173 E2 protein] N 6 - methylpropanoyl]dihydrolipoyl- [+ 4 isozymes] L-methionine [methionine phosphoinositol 1,4-furanose phosphatidyl- phosphatidyl- α-D-Man-(1->3)-[α-D-Man- G3IU-3977 fucose β-D-fructofuranose UDP-D-glucose polyisoprenyl protein-like phosphatidylcholine phosphatidylserine Ptd Gro glycerol putative: G3IU-2347 [+ 3 isozymes] dihydrolipoyl-L-lysine L-lysine (S)-S-oxide a thioredoxin synthase] inositol ethanolamine 2 α kinase, 5-phospho- protein: (1->6)]- -D-Man-(1->4)- UDP-glucose diphosphate beta β α putative: α-D-ribose 1- a phosphatidate -D-GlcNAc-(1->4)- -D- superpathway of central carbon metabolism galactofuranosyl G3IU-5796 phosphoenolpyruvate G3IU-6402 diphosphate pyrophosphorylase: GlcNAc-diphosphodolichol UGP transferase: LPG1 phosphatidic phosphatidic acid α-D-glucose a (1->4)- enolase: fucose a ribonucleotide a ribonucleotide ATP an mRNA α an oxidized acid phosphatase protein- ALG11: ALG11 [mannose β-1,2] -mannose -D-glucan [+ 5 isozymes] fatty acid elongation - unsaturated ENOL kinase, n+1 α-D-glucose 1-phosphate hemoprotein phosphatase, superpathway of mitochondrial fatty acid biosynthesis like protein: G3IU-5796 hexokinase: HK1 hexokinase: HK2 p450 a (mannosyl) -(N- putative: galacto-1-4- putative: 4 2-phospho- hexokinase: HK2 hexokinase: HK1 alpha reductase, a [glycerolipid]- phosphatidic acid acetylglucosaminyl) G3IU-6398 mitochondrial RNA poly(A) polymerase, furanose-β-1-3- G3IU-6068 an acyl-[acyl- stearate 2 D-glycerate β phosphoglucomutase: glucosidase putative: acetyl-CoA linoleate∆ phosphatase, -diphosphodolichol -L-fucose ligase 2: G3IU-5598 putative: G3IU-3313 mannose-α-1- carrier protein] 6 stearic acid phosphoglycerate PGM II subunit, G3IU-3765 a 1,2-diacyl- putative: G3IU-6068 1-phosphate mitochondrial polynucleotide 3-mannose-α-1- desaturase: desaturase, mutase-like putative: sn-glycerol ∆ ALG11: ALG11 RNA editing ligase adenylyltransferase, [+ 2 isozymes] 4-glucosaminyl- acetyl-CoA 6 desaturase putative: a 1,2-diacyl-sn-glycerol protein: G3IU-309 β G3IU-6103 a reduced a [glycerolipid]- -D-glucose-6-phosphate α-D-glucose 6-phosphate 1: G3IU-8457 putative: G3IU-6648 inositol UDP-D-galactose carboxylase, γ G3IU-6718 α-D-Man-(1->2)-α-D- hemoprotein aminoalcoholphosphotransferase, -linolenate [+ 4 isozymes] glucose-6-phosphate putative: oleate diacylglycerol Man-(1->2)-α-D-Man- lactose and galactose degradation I putative: G3IU-120 ∆6 3-phospho- GDP-L-fucose isomerase: PGI a (1->4)- G3IU-2577 acyltransferase, phospholipid:diacylglycerol (1->3)-[α-D-Man-(1->6) glucose-6-phosphate α-D-glucose elongase: ∆12 acyltransferase, D-glycerate [mannose β-1,2] -mannose [mannose β-1,2] -mannose lactose 6- a ribonucleotide an mRNA α-D-glucan putative: G3IU-3998 ]-β-D-Man-(1->4)-β-D- dehydrogenase: G6PD n+1 n a phosphatidylethanolamine 3-oxoacyl- ELO6 desaturase: putative: G3IU-7424 PAS-domain phosphate galactose-α-1- diacylglycerol GlcNAc-(1->4)-α-D- β acyl carrier malonyl-CoA di-homo-γ- ∆12 containing -D-glucose-6-phosphate 3-galacto-1-4- acyltransferase, GlcNAc-diphosphodolichol protein linolenate desaturase phosphoglycerate 6-phospho-D-glucono-1,5-lactone D-fructose-6-phosphate furanose-β-1-3- putative: G3IU-4001 isopentenyl (2E,6E)-farnesyl maltotriose phosphatidylethanolaminen- phosphatidylserine synthase ii, β ∆ kinase, putative: a 1-lysophosphatidylcholine GDP mannose-α-1- phosphatidylserine -ketoacyl- 5 ALG3: ALG3 6-phosphogluconolactonase: glucose-6-phosphate diphosphate diphosphate methyltransferase-lik decarboxylase, an acetyl-[acp] putative: KAS linoleate G3IU-2923 D-galactose guanosine 3-mannose-α-1- synthase: G3IU-6646 ACP desaturase: a triacyl-sn-glycerol 6-phosphogluconolactonase fructose-1,6- 6-phosphofructo- phosphomannose isomerase: PGI e protein: G3IU-2649 putative: G3IU-820 ∆ α α 6-phosphate diphosphatase, 4-glucosaminyl- synthase: KAS 5 desaturase -D-Man-(1->2)- -D-Man- [+ 2 isozymes] bisphosphatase: FBP-1 1-kinase: PFK-1 isomerase: PMI alpha phosphatidylethanolaminen- a malonyl-[acp] (1->2)-α-D-Man-(1->3)-[α- phospholipase dehydrodolichol- putative: phosphoinositol 3-oxoacyl- 6-phospho-D-gluconate glucosidase methyltransferase-lik a phosphatidylserine arachidonate D-Man-(1->3)-α-D-Man- 1,3-diphosphateglycerate A2-like protein, diphosphate G3IU-7353 acyl carrier fructose-1,6-bisphosphate D-mannose 6-phosphate D-fructose-6-phosphate putative: II subunit, e protein: G3IU-2560 α (1->6)]-β-D-Man-(1->4)- 6-phosphogluconate synthase: protein ∆5 -linolenate tagatose-6- putative: β-D-GlcNAc-(1->4)-α-D- glyceraldehyde- dehydrogenase, G3IU-979 G3IU-6938 GMP synthase ii, elongase: phosphomannomutase- phosphate G3IU-6103 galactose-α-1- a phosphatidyl-N- ∆6 GlcNAc-diphosphodolichol 3-phosphate decarboxylating, like protein: G3IU-1363 [+ 2 isozymes] putative: KAS ELO5 fructose-1,6-bisphosphate tagatose-6- 6-galactose-α- methylethanolamine desaturase: dehydrogenase- putative: G3IU-947 phosphomannomutase: PMM 7,10,13,16- ∆ aldolase: ALD phosphate geranylgeranyl 1-3-galacto1-4- 6 desaturase ALG9: ALG9 like protein: L-1-glycero-3- α-D-glucose maltose docosatetraenoate UDP-galactose biosynthesis D-ribulose-5-phosphate α kinase-like a carboxylate diphosphate furanose-β-1-3- G3IU-805 -D-mannose 1-phosphate phosphocholine an acetoacetyl-[acp] ∆4 stearidonate α-D-Man-(1->2)-α-D-Man- triosephosphate isomerase: protein: mannose-α-1- [+ 3 isozymes] a phosphatidyl-N- desaturase: (1->2)-α-D-Man-(1->3) triosephosphate isomerase G3IU-730 3-mannose-α-1- an acetoacetyl-[acp] ∆6 α-D-glucose ribulose-phosphate ribose 5-phosphate D-glyceraldehyde-3-phosphate dihydroxyacetone phosphate dimethylethanolamine ∆4 desaturase -[α-D-Man-(1->2)-α-D- dihydroxyacetone D-glyceraldehyde- 4-glucosaminyl- GDP-α-D- elongase: phosphate 3-phosphate 3-epimerase, isomerase, tagatose-6- ATP H O a ferricytochrome Peptide Man-(1->3)-α-D-Man- hexokinase: HK1 diphosphate H O 2 phosphoinositol mannose 4,7,10,13,16- ELO6 putative: G3IU-913 putative: G3IU-3692 glyceraldehyde-3- phosphate 2 b β 5 docosapentaenoate (1->6)]- -D-Man-(1->4)- hexokinase: HK2 phosphate dehydrogenase- mannose α-1,4-cyclic phosphate GDP-α-D-mannose kinase-like NADH- calpain β α fructose-1,6- ribulose-5-phosphate eicosatetraenoate -D-GlcNAc-(1->4)- -D- like protein: G3IU-805 protein: cytochrome protease- acetoacetyl-ACP a 3-oxoacyl-[acp] bisphosphate α-D-glucose 6-phosphate 3-epimerase, D-ribose 5-phosphate serine peptidase, a phosphatidylcholine GlcNAc-diphosphodolichol [+ 3 isozymes] G3IU-8370 acidocalcisomal b5 reductase- like protein: ∆ aldolase: ALD putative: G3IU-1941 Clan SJ, family 5 pyrophosphatase: like protein: G3IU-1895 mannose-α-1- β-ketoacyl- phosphoglucomutase: tagatose-1,6- S16, putative: desaturase: 1,3-diphosphateglycerate G3IU-7196 G3IU-7190 [+ 9 isozymes] phosphate-6- ACP ∆5 desaturase fructose-1,6- PGM bisphosphate G3IU-8245 α α D-xylulose-5-phosphate [mannose β-1,2] -mannose [+ 2 isozymes] [+ 5 isozymes] Peptide galactose-α-1- reductase: -D-Man-a-(1->2)- -D- bisphosphate 1-4 PAS-domain containing α a ferrocytochrome α KAR3 eicosapentaenoate Man-(1->2)-α-D-Man- α-D-glucose 1-phosphate -1,4-cyclic phosphate 6-galactose- - fructose-1,6- α-D-galactose phosphoglycerate kinase, b α + 5 1-3-galacto-1- glycoinositolphospholipid (GIPL) biosynthesis [+ 3 isozymes] (1->3)-[ -D-Man-(1->2) bisphosphatase: transketolase: G3IU-4769 + ADP phosphate H ∆5 putative: G3IU-2923 phosphate H 4-furanose-β-1- -α-D-Man-(1->3)-[α-D- FBP-1 UDP-glucose galactokinase: sucrose degradation I dihydroxyacetone D-glyceraldehyde- a (3R)-3-hydroxyacyl- elongase: α pyrophosphorylase: UGP [+ 2 isozymes] 3-mannose-α-1- a 1-phosphatidyl- Man-(1->6)]- -D-Man- D-fructose- G3IU-1007 phosphate 3-phosphate [acyl-carrier protein] ELO5 β D-sedoheptulose 7-phosphate D-glyceraldehyde-3-phosphate sucrose-6- 3-mannose-α-1- 1D-myo-inositol (1->6)]- -D-Man-(1->4)- 6-phosphate 3-phospho-D-glycerate β α UDP-D-glucose α phosphate β a 2'- 4-glucosaminyl- phosphatidylinositolN- enoyl-[acyl- 7,10,13,16,19- -D-GlcNAc-(1->4)- -D- -D-galactose 1-phosphate a (1->2)- -D-mannan glucose-6- NADH A deoxyribonucleoside acetoin copper- inositol acetylglucosaminyltransfe carrier- docosapentaenoate GlcNAc-diphosphodolichol transaldolase, phosphoglycerate mutase- oligosaccharide ∆ phosphate udp-glc 4'-epimerase, beta- 5'-diphosphate acetoin transporting ra sesubunit c, protein] 4 putative: G3IU-6369 like protein: G3IU-309 ribose ribonucleoside- 2+ 2+ isomerase: putative: G3IU-1866 fructofuranosidase- trehalose dehydrogenase Cu ATPase- Cu putative: G3IU-554 reductase, desaturase: [+ 4 isozymes] degradation 1,2-β- diphosphate like protein, putative: ∆4 desaturase PGI like protein: degradation NADH e3 component- n-acetylglucosaminyl- α-D-Man-(1->2)-α-D-Man- D-erythrose-4-phosphate D-fructose-6-phosphate 2-phospho-D-glycerate oligomannan dehydrogenase, reductase small putative galactose-β-1- G3IU-1694 β-D-glucose- UDP-D-galactose G3IU-1214 β II (trehalase) like protein: phosphatidylinositolbiosyn 4,7,10,13,16,19- (1->2)-α-D-Man-(1->3)-[α- -D-ribopyranose phosphorylase: putative: G3IU-174 chain, putative: 4-mannose-α- [+ 2 isozymes] docosahexaenoate 6-phosphate UDP-galactopyranose [+ 4 isozymes] trehalose G3IU-5230 G3IU-2613 th eticprotein, D-Man-(1->2)-α-D-Man- MPT3 [+ 2 isozymes] 1-phosphate-6- mutase: GLF transketolase: G3IU-4769 enolase: ENOL glycosyl diacetyl putative: G3IU-1930 a trans-2-enoyl- (1->3)-[α-D-Man-(1->2)-α- β [+ 3 isozymes] [+ 2 isozymes] galactose-α-1- β -D-glucose- β hydrolase, a ribonucleoside a 6-(N-acetyl-α- [acyl-carrier protein] D-Man-(1->6)]-α-D-Man- UDP-D-galacto-1,4-furanose -D-fructofuranose -D-ribofuranose 6-galactose-α- D-glyceraldehyde-3-phosphate 6-phosphate putative: diphosphate D-glucosaminyl)- (1->6)]-β-D-Man-(1->4)- phosphoenolpyruvate a (1->2)-β-D-mannan α A(H2) NAD + 1-3-galacto-1- hexokinase: G3IU-189 -D-mannose 1-phosphatidyl- glycophosphatidylinositol β-D-GlcNAc-(1->4)-α-D- oligosaccharide 4-furanose-β-1- sucrose biosynthesis HK2 β-D-glucose 1-phosphate 3-mannose-α-1- 1D-myo-inositol (GPI) anchor biosynthesis GlcNAc-diphosphodolichol pyruvate kinase, phosphoenolpyruvate hexokinase: N-acetyl-D- D-ribose 3-mannose-α-1- a 2,3,4-saturated β-D-glucose- putative: G3IU-1274 carboxykinase: G3IU-3976 HK1 glucokinase: a feruloyl- a 2,3,4- glucosaminylphosphatidylinositol a 1-phosphatidyl-1D-myo-inositol GDP-mannose biosynthesis a 2'-deoxyribonucleoside 4-glucosaminyl- fatty acyl-[acp] 6-phosphate pyruvate kinase, phosphoenolpyruvate D-fructose- ribokinase, GlcK polysaccharide saturated (3R)-3- acetoin deacetylase: GPI12 phosphatidylinositolN- 5'-triphosphate [DNA] phosphoinositol 6-(α-D-glucosaminyl) α α putative: G3IU-1273 carboxykinase: G3IU-3977 6-phosphate putative: β-D-glucose- hydroxyacyl-CoA acetoin acetylglucosaminyltransfe -D-Glc-(1->3)- -D-Man- enoyl-CoA -1-phosphatidyl- α α D-mannose G3IU-4120 6-phosphate dehydrogenase ra sesubunit c, (1->2)- -D-Man-(1->2)- - xylose hypothetical hydratase/ 1D-myo-inositol α D-ribose 5- DNA polymerase: e3 component- putative: G3IU-554 D-Man-(1->3)-[ -D-Man- α-D-glucose D-fructose- pyruvate oxaloacetate degradation I protein, isomerase- (1->2)-α-D-Man-(1->3) hexokinase: phosphate mitochondrial DNA like protein: (mannose-α-1- n-acetylglucosaminyl- 6-phosphate 6-phosphate conserved: like protein: GPI14: GPI14 sphingolipid metabolism -[α-D-Man-(1->2)-α-D- HK1 pyruvate dehydrogenase malate α-D-xylose polymerase beta G3IU-251 G3IU-2613 2) -(galactose-β- phosphatidylinositolbiosyn D-mannose G3IU-3342 2 Man-(1->6)]-α-D-Man- phosphoglucomutase: phosphomannose hexokinase: multienzyme complex: dehydrogenase: cMDH [+ 10 isozymes] diacetyl 1-4-mannose-α- α th eticprotein, UDP-D-galactose mannose- -1- (1->6)]-β-D-Man-(1->4)- PGM G3IU-5523 G3IU-456 malate degradation [+ 8 isozymes] 1-phosphate-6) putative: G3IU-1930 isomerase: PMI HK2 a (2E)-2- 4-glucosaminyl- ser a 6-(N-acetyl-α-D-glucosaminyl)- β-D-GlcNAc-(1->4)-α-D- α-D-glucose G3IU-3390 GCVL dehydrogenase: gMDH a polysaccharide -galactose- UDP- D-xylulose D-fructose- ferulate enoyl-CoA 15-30 phosphoinositol E1α G3IU-4563 [DNA] α galactopyranose 1-phosphatidyl-1D-myo-inositol GlcNAc-diphosphodolichol 1-phosphate D-mannose 6-phosphate -1-6-galactose- serine (S)-malate xylulokinase, phosphomannose α mutase: GLF N-acetyl-D- UDP-glucose 6-phosphate -1-3-galacto-1- GPI18: GPI18 palmitoyltransferase: acetyl-CoA putative: isomerase: PMI β glucosaminylphosphatidylinositol pyrophosphorylase: phosphomannomutase- D-mannose 4-furanose- -1- UDP-D-galacto- SPT1 SPT2 oxaloacetate deacetylase: GPI12 like protein: G3IU-1363 fumarate hydratase: FHc G3IU-703 a (1->4)- a 2,3,4- α 3-mannose-α-1- 1,4-furanose mannose-α-1- mannose-α-1- α-D-Glc-(1->3)-α-D-Glc- UGP citrate synthase, 6-phosphate phenylpyruvate -maltose α D-xylulose- asp α-D-glucan saturated (3S)-3- 3-mannose-α-1- 3-mannose-α-1- 6-mannose-α-1- 3-dehydrosphinganine 6-( -D-glucosaminyl)-1- (1->3)-α-D-Man-(1->2) phosphomannomutase: putative: G3IU-6042 alpha β UDP-D-glucose 5-phosphate hydroxyacyl-CoA 4-glucosaminyl-side chain 1,3 4-glucosaminyl- 4-glucosaminyl- phosphatidyl-1D-myo-inositol -α-D-Man-(1->2)-α-D- PMM citrate synthase, fumarate enoyl-CoA glucosidase α phosphorylase phosphoinositolgalactosyltransferase phosphoinositol phosphoinositol Man-(1->3)-[α-D-Man- -D-mannose putative: G3IU-6043 hydratase/ II subunit, GPI14: GPI14 broad specificity kinase-like 4: SCG4 fatty acid biosynthesis (1->2)-α-D-Man-(1->3) sucrose- 1-phosphate mitochondrial malate fumarate reductase: FRDg isomerase- putative: aminotransferase: protein: side chain β1,3 beta GPI10: GPI10 -- elongase pathway -[α-D-Man-(1->2)-α-D- phosphate GDP-mannose dehydrogenase: mMDH like protein: G3IU-6103 a sphinganine mannose-α-1-4-glucosaminyl- oxaloacetate G3IU-1196 G3IU-3689 galactosyltransferase: galactofuranosyl Man-(1->6)]-α-D-Man- synthase- pyrophosphorylase: [+ 3 isozymes] G3IU-3342 phosphoinositol UDP succinate degradation α-D-glucose SCG3 transferase: LPG1 mannose-α-1-6- mannose-α-1- acetyl-CoA (1->6)]-β-D-Man-(1->4)- like protein: sucrose GDPMP [+ 6 isozymes] G3IU-6349 (S)-malate citrate to pyruvate a 2,3,4-saturated side chain β1,3 [+ 5 isozymes] [mannose-α-1- 2-mannose-α-1- β-D-GlcNAc-(1->4)-α-D- GDP-α-D- a (1->4)- α-D-glucose GPI18: GPI18 acetyl-CoA Amino Acid Degradation oxaloacetate α 3-oxoacyl-CoA galactosyltransferase 3]-mannose-α-1- 6-mannose-α-1- GlcNAc-diphosphodolichol mannose oxaloacetate phe -D-glucan 1-phosphate carboxylase, sucrose-6- 2: SCG2 galacto-1-4-furanose- 4-glucosaminyl- 4-glucosaminyl- mannose-α-1-6-mannose-α-1- malate β-1-3-mannose-α-1- sphinganine 4-hydroxysphinganine putative: phosphate side chain β1,3 phosphoinositol phosphoinositol 4-glucosaminyl-phosphoinositol dehydrogenase- valine degradation I 3-mannose-α-1-4- 1-phosphate G3IU-2577 isoleucine degradation I galactosyltransferase aconitase, putative: like: G3IU-1743 S-(2-hydroxyacyl) α glucosaminyl-inositol sphingosine- dolichyl ATP H O L-glutaminyl- (mannose- -1-2) GPI10: GPI10 G3IU-6061 [+ 2 isozymes] a tRNA precursor 2 1: SCG1 an acyl-CoA malonyl-CoA diphosphooligosaccharide mitochondrial fumarate val ATP glutathione -(galactose-beta- 1-phosphate (S)-malate ile CTP peptide 2 [+ 10 isozymes] mannose-α-1-2- mannose-α-1-2-mannose- hydratase: FHm glutaminyl 1-4-[galactose-β- lyase: SPL mannose-α-1-6- α-1-6-mannose-α-1-4- cyclase, 1-4] -mannose- phosphoryl- a phytoceramide phytosphingosine-1-P fatty acid fumarate cis-aconitate malic enzyme, branched-chain kinesin, putative: glyoxalase 1-5 galactose-α-1-3- α branched-chain [mannose- -1- glucosaminyl-phosphoinositol elongase putative: amino acid tRNA G3IU-1072 II, putative: putative: α-1-phosphate-6) galacto-1-4-furanose- α ethanolamine aconitase, putative: amino acid 3]-mannose- -1- (ELO3.2): ELO3.2 succinate dehydrogenase, G3IU-4901 aminotransferase, nucleotidyltransferase, G3IU-7057 a peptide withG3IU-7977 -galactose- β-1-3-mannose-α- G3IU-6061 aminotransferase, [+ 31 isozymes] 15-30 4-glucosaminyl- putative: G3IU-3952 putative: G3IU-8080 N-terminal 5- α-1-6-galactose- α [+ 3 isozymes] putative: G3IU-6512 1-3-mannose- - phosphoinositol pyruvate putative: G3IU-3952 oxo-L-proline α-1-3-galacto-1- 1-4-glucosaminyl- a (2'R)-2'- ethanolamine-phosphate-6- succinate dehydrogenase a 2-hydroxy 2-oxoisovalerate 2-keto-3- a tRNA + glutathione 4-furanose-β-1- hydroxy- mannose-α-1-2-mannose- a 2,3,4-saturated flavoprotein, ADP phosphate H phosphoinositol methyl-valerate containing a carboxylate 3-mannose-α-1- phytoceramide α-1-6-mannose-α-1-4- 3-oxoacyl-CoA putative: G3IU-4813 3' CCA end 3-mannose-α-1- glucosaminyl-phosphoinositol 4-glucosaminyl- biotin-carboxyl gpi transamidase: succinate D-threo-isocitrate α isocitrate dehydrogenase, phosphoinositol GDP-D-arabinose galactose- -1-6- carrier protein TTA2 TTA1 isobutyryl-CoA 2-methylbutanoyl- an organic a [protein]- α (4R)-4-hydroxy-N-[(2R)-2- a 2,3,4-saturated (3R putative: G3IU-1841 ATP H O dihydrolipoate an oxidized galactose- -1-3- assembly GPI16 GAA1 GPI8 2 hydroxy-very-long-chain-acyl]- succinyl-CoA CoA hydroperoxide L-cysteine cytochrome c galacto1-4-furanose- )-3-hydroxyacyl-CoA isocitrate dehydrogenase dihydrolipoamide 3 phosphoglycan beta 1,2 biotin carboxyl- β-1-3-mannose-α- 1-O-[(1D-myo-inositol-1-O-yl) a protein-GPI anchor synthetase: G3IU-4520 [NADP], mitochondrial dehydrogenase: hydrogenase, arabinosyltransferase: carrier protein enoyl-CoA 1-3-mannose-α- hydroxyphosphoryl]sphinganine [+ 2 isozymes] precursor, putative: tryparedoxin katanin, GCVL putative: G3IU-1704 hydratase/ putative: 1-4-glucosaminyl- biotin/ isomerase- G3IU-7337 methylacrylyl-CoA (E)-2- peroxidase: dihydrolipoamide G3IU-8050 side chain β1,2 G3IU-812 phosphoinositol lipoate like protein: methylcrotonoyl- G3IU-5173 dehydrogenase: a reduced arabinosyltransferase: protein very long chain fatty acid biosynthesis a mannosylinositol enoyl-CoA CoA [+ 7 isozymes] cytochrome c G3IU-3342 succinyl-CoA 2-oxoglutarate G3IU-3390 3 SCA2 ligase-like phospho-(2'R)-2'- hydratase/ enoyl-CoA β [+ 8 isozymes] isomerase- hydratase/ ADP phosphate H + (R)-lipoate side chain 1,2 protein: a long-chain acyl-CoA hydroxyphytoceramide an intra- fatty acid like protein: isomerase- an alcohol arabinosyltransferase: G3IU-2773 a (2E)-2-enoyl-CoA protein disulfide SCA1 elongase: ELO4.1 G3IU-3342 like protein: a biotinylated [+ 6 isozymes] enoyl-CoA [+ 8 isozymes] G3IU-3342 fatty acid [BCCP monomer] a mannosyl- 2-oxoglutarate α reductase: EnCR [+ 8 isozymes] a 2-[(3S)-3-amino- 4,4- (mannose- -1- activation diphosphoinositol-(2'R)- dehydrogenase complex: (S)-3-hydroxy- 5-hydroxyferulate coenzyme A fumarate 2) -(galactose- 2-methyl-3- 3-carboxypropyl]-L- dimethylzymosterol 2 a long-chain acyl-CoA a 2,3,4-saturated 3-oxoacyl-CoA 2'-hydroxyphytoceramide a 2,3,4-saturated G3IU-4073 G3IU-372 isobutyryl-CoA β hydroxybutyryl- mitochondrial NADH- histidine-[translation C-14 sterol -1-4-[arabinose- a long-chain fatty acyl CoA G3IU-2614 G3IU-3645 galactose-β-1-4] fatty acid CoA dependent fumarate elongation factordiphthine 2] reductase, 1- acyl-CoA G3IU-3390 GCVL 4-coumarate:coa 5-mannose-α-1- a biotinylated Amino Acid Biosynthesis reductase: FRDm synthase- putative: synthetase, ligase-like protein: phosphate) [BCCP dimer] (S)-3-hydroxy- NADH-dependent like protein: G3IU-2308α 15- G3IU-5837 4,4-dimethyl-5- - putative; a 2,3,4-saturated (3R isobutyrate fumarate reductase, a 2-[(3S)-3-carboxy-3-G3IU-2718 30-6-galactose- acetyl-CoA a (2E)-2-enoyl-CoA superpathway of S-adenosylmethionine metabolism 2-methylacetoacetyl- cholesta-8,14,24- α fatty acid proline threonine biosynthesis [+ 2 isozymes] putative: G3IU-1160 (methylammonio)propyl]- -1-6-galactose- carboxylase, )-3-hydroxyacyl-CoA methionine biosynthesis superpathway of serine alanine glutamate 3-hydroxyisobutyrate CoA trien-3-β-ol α thiokinase biosynthesis II from homoserine L-histidine-[translation -1-3-galacto-1- putative: 2-oxo-4- and glycine biosynthesis I biosynthesis III biosynthesis II dehydrogenase, succinate β (long chain) elongation factor 2] 4-furanose- -1- G3IU-2577 methylthiobutanoate putative: G3IU-3267 5-hydroxy-feruloyl-CoA α , putative: enoyl-CoA hydratase/ L-homoserine 3-phospho- 3-mannose- -1- a carboxylated- glt L-homoserine cys 2-oxoglutarate (S)-methylmalonate- α G3IU-6898 isomerase-like homoserine D-glycerate glutamate 3-mannose- -1- biotinylated broad specificity pyrroline-5- D-3- homoserine cysteine semialdehyde [+ 7 isozymes] protein: G3IU-3342 kinase, putative: dehydrogenase: 4-glucosaminyl- a long-chain [BCCP dimer] aminotransferase: carboxylate phosphoglycerate kinase, desulfurase, acetyl-CoA propanoyl-CoA all-trans- pyruvate phosphoinositol [+ 8 isozymes] G3IU-2954 dehydrogenase-like glutamate dihydrolipoamide acyl-CoA G3IU-1196 synthetase: O-phospho-L-homoserine putative: putative: geranyl-geranyl a [protein]- dehydrogenase a malonyl-[acp] protein: G3IU-8294 dehydrogenase tyrosine G3IU-2222 3-phospho- O-phospho-G3IU-2954 G3IU-4054 diphosphate L-cysteine dihydrolipoamide E1α ala glt pyruvate aminotransferase, glutamate hydroxypyruvate L-homoserine (S)-3-amino-2- dehydrogenase: dehydrogenase putative: G3IU-486 propanoyl-CoA GCVL 5-kinase, threonine methylpropanoate superpathway of threonine degradation geranylgeranyltransferase, (lipoamide) 1,2-dihydroxy- putative: synthase, putative: G3IU-1336 dihydrolipoamide kinase, putative: G3IU-4214 dehydrogenase: 5-(methylthio) met s-adenosylmethionine L-glutamate- L-cystathionine putative: glutamine a phosphorylatedG3IU-4974 acetoacetyl-ACP 3-phospho- thr G3IU-3390 pent-1-en-3-one synthetase; methionine 5-phosphate G3IU-6735 biosynthesis II pyruvate L-serine a [protein]-S- lipoamide adenosyltransferase: pyrroline-5- cystathionine dehydrogenase beta-lyase, thr geranylgeranyl- cobalamin- METK1 carboxylate glt proline degradation serine serine- putative: L-cysteine independent s-adenosylmethionine synthetase: glutamine hydroxymethyltransferase: threonine G3IU-2276 methioninecobalamin- synthetase; methionine G3IU-2222 cysteine biosynthesis I synthetase, SHMT-S dehydratase: dependent putative: pro a 1-phosphatidyl- synthase: adenosyltransferase: γ-glutamyl- cystathionine ser serine G3IU-7873 oxaloacetate a D-hexose methionine G3IU-7912 proline tyr a phosphoprotein 1D-myo-inositol G3IU-2880 METK2 phosphate beta-lyase- hydroxymethyltransferase: hexokinase: synthase: ser gln oxidase: serine/threonine 4,5-bisphosphateinositol reductase: like protein: serine SHMT-L HK1 2-hydroxy-3-keto- G3IU-7803 G3IU-6723 hydroxymethyltransferase: serine (S)-1-pyrroline-G3IU-4327 2-oxobutanoate protein polyphosphate G3IU-8309 acetyltransferase, broad specificity hexokinase: 5-methylthio-1- modification SAM SHMT-L 5-carboxylate phosphatase-like phosphatase, phosphopentene L-glutamate γ- L-homocysteine putative: G3IU-1457 aminotransferase: protein: G3IU-4276 putative: HK2 L-homocysteine methylase- serine O-acetyl-L-serine delta-1-pyrroline- gly D-hexose 6- S-adenosylmethionine semialdehyde G3IU-1196 [+ 37 isozymes] a 1-phosphatidyl-G3IU-4896 like protein: hydroxymethyltransferase: 5-carboxylate phosphate G3IU-4618 decarboxylase: cobalamin- cobalamin- SHMT-S dehydrogenase, serine a protein 1D-myo-inositol S-adenosylhomocysteine homocysteine S- homocysteine S- ornithine ADOMETDC independent dependent cysteine synthase, putative: hydroxymethyltransferase: 4-hydroxyphenylpyruvate 4-phosphate hydrolase: S- methionine methyltransferase, methyltransferase, methionine putative: G3IU-360 biosynthesis asp adenosylhomocysteine S-adenosylmethionine gly G3IU-8278 SHMT-L (S)-1-pyrroline- synthase: putative: G3IU-79 putative: G3IU-79 synthase: (arginine hydrolase decarboxylase degradation) serine proenzyme-like, 5-carboxylate G3IU-2880 G3IU-7803 cys glt S-adenosyl-L- hydroxymethyltransferase: putative: G3IU-2950 pyrroline-5- arg D-fructose- a nucleoside homocysteine met cysteine biosynthesis/ SHMT-S 4-coumarate 5-(methylthio)- carboxylate arginase, a histone 6-phosphate diphosphate 2,3-dioxopentyl S-adenosyl-L- homocysteine putative: 6-phosphofructo- methioninamine reductase: degradation ser histone nucleoside phosphate P5CR homoserine G3IU-1132 acethyltransferase- 2-kinase: diphosphatase, biosynthesis selenocysteine biosynthesis I (bacteria) L-ornithine 4-coumarate:coa ligase- PFK-2.1 L-homocysteine ser serine- tyrosine degradation I like protein: putative: like protein: G3IU-5837 6-phosphofructo- pro threonine G3IU-6422 G3IU-6610 spermidine [+ 2 isozymes] 2-kinase: PFK2.2 asp sec ser [+ 3 isozymes] a nucleotide synthase, tRNA aspartate biosynthesis dehydratase: β-D-fructose 2,6- putrescine cystathionine tyr an acetylated putative: G3IU-7873 bisphosphate beta-synthase: broad specificity + histone G3IU-8142 AMP 4-coumaroyl-CoA diphosphate H CYSB pyruvate aminotransferase: L-aspartyl- hydrogen selenide seryl-tRNA oxaloacetate asparagine spermidine broad specificity G3IU-1196 alanine 4-phosphate synthetase, biosynthesis biosynthesis II selenophosphate putative: aminotransferase: tyrosine 5-methylthioribulose- S-methyl-5'- L-cystathionine synthetase, G3IU-7207 G3IU-1196 aminotransferase, sn-glycerol- L-ascorbate- 1-phosphate thioadenosine asp trans-caffeate a reduced electron methylthioadenosine pyruvate putative: G3IU-171 aspartate putative: G3IU-486 transferring flavoprotein 3-phosphate 6-phosphate phosphorylase: cystathione asparagine broad specificity an L-seryl- aminotransferase, glutamate degradation 4-hydroxyphenylpyruvate electron transfer glycerol-3- ascorbate- G3IU-7989 L-aspartate- selenophosphate gamma lyase: synthetase dependent aminotransferase: [tRNA sec ] putative: G3IU-4939 4-coumarate:coa ligase- flavoprotein- phosphate semialdehyde G3IU-958 a, putative: peroxidase, G3IU-1196 asp like protein: G3IU-5837 ubiquinone dehydrogenase- homoserine G3IU-4405 glt oxidoreductase, like protein: putative: APX alanine cys [+ 2 isozymes] L-dehydro- dehydrogenase- asn glutamate glutamate putative: G3IU-7750 G3IU-5717 aminotransferase, homogentisate dihydroxyacetone ascorbate putative: G3IU-7016 like protein: dehydrogenase: dehydrogenase, an oxidized electron an L- glutamate putative: transferring flavoprotein phosphate G3IU-7786 AMP caffeoyl-CoA H + ala selenocysteinyl- dehydrogenase G3IU-3594 diphosphate 5-methylthioribose- L-homoserine [tRNA sec ] 2-oxoglutarate 1-phosphate 4-maleyl- 2 acetoacetate N -succinyl- ferulate L-glutamate 5- NADPH malonyl-CoA semialdehydedelta-1-pyrroline- quinone malonyl-coa oxidoreductase, decarboxylase- 4-coumarate:coa ligase- 5-carboxylate 4-fumaryl- dehydrogenase, putative: like protein: glycine cleavage complex acetoacetate like protein: G3IU-5837 G3IU-8242 G3IU-7736 [+ 2 isozymes] putative: a [glycine-cleavage G3IU-8278 [+ 2 isozymes] acetyl-CoA 2 complex H protein] N 6 N - a semiquinone succinylglutamate -[(R)-lipoyl]-L-lysine glycine AMP feruloyl-CoA diphosphate dihydrolipoamide decarboxylase: fumarate dehydrogenase: GCVP GCVL cytidine dihydrolipoamide ATP H O 2 a protein a cytosine in DNA dehydrogenase: a [glycine-cleavage tryptophan map-kinase modification G3IU-3390a [glycine-cleavage nonspecific complex H protein] N 6 - degradation I homologue: methylase- complex H protein] N 6 N-ethylmaleimide- nucleoside aminomethyldihydrolipoyl- (via anthranilate) G3IU-60 like protein: -dihydrolipoyl-L-lysine sensitive factor, hydrolase: NH L-lysine G3IU-4618 trp putative: G3IU-5685 [+ 137 isozymes] a DNA 5- a phosphoprotein methylcytosine cytosine D-ribose ADP H + aminomethyltransferase, N-formylkynurenine phosphate mitochondrial precursor, putative: GCVT [+ 2 isozymes] (2E,6E)-farnesyl a 1-phosphatidyl- uridine β-D-glucose protoheme IX 1D-myo-inositol kynurenine diphosphate phosphatidylinositol hexokinase: 3-related kinase, nonspecific HK1 kynureninase, tyrosine degradation II asparagine protoheme IX putative: G3IU-2401 nucleoside hexokinase: putative: degradation farnesyltransferase, hydrolase: NH HK2 G3IU-4262 a 1-phosphatidyl-[+ 6 isozymes] putative: G3IU-4987 β-D-glucose- tyr 1D-myo-inositol 6-phosphate asn anthranilate 3-phosphate D-ribose uracil broad specificity cytoplasmic l- aminotransferase: asparaginase heme o G3IU-1196 i-like protein: tyrosine G3IU-6570 aminotransferase, tryptophan degradation asparaginase- pyruvate a [protein] C-terminal lathosterol putative: G3IU-486 like protein: S-farnesyl-L-cysteine a tRNA 4-hydroxyphenylpyruvate prenyl protein lathosterol G3IU-272 trp tRNA-methyl specific carboxyl oxidase- asp broad specificity transferase, pyruvate phosphate methyltransferase, putative: like protein: aminotransferase: dikinase: G3IU-7116 putative: G3IU-978 G3IU-5023 G3IU-1196 a [protein] C-terminal a 5-[(methylamino)G3IU-7799 7-dehydro- 4-hydroxyphenylacetate indole-3-pyruvate S-farnesyl-L- methyl]-2- cholesterol cysteine methyl ester thiouridine 34 in tRNA alanine AMP phosphoenolpyruvate diphosphate H + degradation III

indole-3-lactate ala a [protein]-L- RNase II malonyl-CoA NAD(P)H H + stearoyl-CoA salicylate broad specificity β-isoaspartate degradation aminotransferase: protein-L- substrate mRNAmitochondrial hypothetical G3IU-1196 isoaspartate O- exoribonuclease protein, fatty acid elongase, methyltransferase, conserved: alanine aspartate degradation putative: ELO4.4 DSS-1, putative: βputative: G3IU-50 G3IU-4224 aminotransferase, [+ 6 isozymes] a protein L- - G3IU-1757 putative: G3IU-7016 isoaspartate a nucleoside- catechol pyruvate asp α-methyl ester 5'-phosphate broad specificity arachidoyl-CoA aminotransferase: G3IU-1196 aspartate a 1-phosphatidyl- α-D-glucose acetyl-CoA degradation to acetate aminotransferase, a 2'-deoxyribonucleotide (deoxynucleotides) an aldehyde (m) 1D-myo-inositol 6-phosphate putative: G3IU-4939 3-phosphate aldehyde glucose-6- acetyl-CoA succinate oxaloacetate phosphatidylinositol dehydrogenase, phosphate DNA ligase I, (3,5) kinase, putative: G3IU-549 isomerase: putative: G3IU-2917 putative: G3IU-4072 [+ 2 isozymes] PGI [+ 3 isozymes] 1-phosphatidyl- D-fructose- 1D-myo-inositol an acid 6-phosphate acetyl-CoA 3,5-bisphosphate synthetase, a 2'-deoxyribonucleotide putative: succinyl-CoA acetyl:succinate G3IU-5121 synthetase: CoA-transferase: G3IU-4520 acetyl-CoA ASCT a 1,2-diacyl- [+ 2 isozymes] a phospholipid isovaleryl-CoA a nitrile synthetase, sn-glycerol SAM putative: isovaleryl-coA nitrilase, G3IU-5093 dehydrogenase, phospholipid:diacylglycerol methyltransferase, putative: putative: acyltransferase, putative: G3IU-759 G3IU-4258 an N 7 - G3IU-4068 putative: G3IU-7424 3-methylcrotonyl- a carboxylate methylguanine CoA acetate succinyl-CoA in tRNA a triacyl-sn a lysophospholipid -glycerol Secondary Metabolite Degradation uridine 3-mercaptopyruvate hydrogen cyanide campest-4- galactitol degradation Protein en-3-one uridine N-acetylglucosamine 3-oxo-5-alpha- kinase-like degradation I calcium/calmodulin- steroid 4- galactitol-1- protein: N-acetyl-D- 3-mercaptopyruvate dependent protein dehydrogenase, phosphate G3IU-2631 glucosamine sulfurtransferase: kinase, putative: putative: EnCR 6-phosphate MST G3IU-4803 (5α)-campestan- UMP n-acetylglucosamine- O-PHOSPHOPROTEIN 6-phosphate 3-one tagatose-6- deacetylase-like phosphate thiocyanate pyruvate D-glucosamineprotein: G3IU-726 tagatose-6- 6-phosphate phosphate glucosamine- kinase-like a 1-phosphatidyl- a ceramide a 1-phosphatidyl- β-D-fructose 2,6- L-ribulose protein: 6-phosphate 1D-myo-inositol 1D-myo-inositol bisphosphate xylitol L-ribulokinase, G3IU-730 deaminase, phosphatidylinositol fructose-2,6- putative: degradation putative: inositol 4-kinase, putative: bisphosphatase: tagatose-6- G3IU-2210 G3IU-1383 G3IU-724 phosphate xylitol phosphorylceramide FBP-2 D-fructose- a 1-phosphatidyl- D-fructose- L-ribulose- kinase-like d-xylulose synthase: IPCS 6-phosphate 1D-myo-inositol 6-phosphate 5-phosphate protein: reductase: 4-phosphate G3IU-8370 G3IU-2067 a 1,2-diacyl- an inositol tagatose-1,6- D-xylulose sn-glycerol phosphodihydroceramide bisphosphate xylulokinase, putative: fructose-1- UDP-D-glucose D-ribulose G3IU-703 phosphate met D-xylulose- UDP- L-ribulokinase, dihydroxyacetone D-glyceraldehyde- 5-phosphate broad specificity glucose 4,6 putative: phosphate 3-phosphate fructose-1,6- aminotransferase: dehydratase: bisphosphate G3IU-724 G3IU-1196 G3IU-4263 D-ribulose- aldolase: ALD 2-oxo-4- UDP-4-dehydro- 5-phosphate D-arabitol methylthiobutanoate 6-deoxy-D-glucose Nucleoside and Nucleotide Degradation degradation dihydroxyacetone D-glyceraldehyde phosphate (deoxy)ribose phosphate degradation D-arabitol

deoxycytidine DNA with uracil due to a DNA cyclobutadipyrimidine an acyl phosphate D-xylulose misincorporation or DNA repair enzyme, deamination of cytosine xylulokinase, putative: G3IU-2072 acylphosphatase, uracil-DNA- putative: DNA photolyase, putative: G3IU-4538 glycosylase: cytidine deoxyuridine thymidine G3IU-6064 G3IU-703 putative: G3IU-7493 DNA with uracil cleaved two adjacent pyrimidine a carboxylate D-xylulose- out leaving an AP site 5-phosphate nucleosides in DNA uridine deoxyribose 1-phosphate glycyl-peptide β-D-galactose ribulose aldose 1-epimerase, L-ribulokinase, uracil α-D-ribose- N-myristoyltransferase: putative: G3IU-1181 putative: 1-phosphate 2-deoxy-α- NMT aldose 1-epimerase- G3IU-724 D-ribose 1- N-tetradecanoylglycyl- like protein: G3IU-5132 L(or D)-ribulose phosphate peptide α-D-galactose 5-phosphate D-ribose 5- phosphate 2-deoxy-D-ribose L-carnitine dihydroxy-acetone (S)-dihydroorotate transketolase: 5-phosphate G3IU-4769 carnitine dihydroxyacetone dihydroorotate kinase 1-like D-sedoheptulose deoxyribose- palmitoyltransferase- dehydrogenase: protein: G3IU-7325 7-phosphate phosphate like protein: G3IU-5326 DHODH dihydroxyacetone aldolase, orotate L-Palmitoylcarnitine phosphate putative: G3IU-7838

D-glyceraldehyde- 3-phosphate acetaldehyde

adenosine adenosine H O thymidine thymidine a phospholipid 2 glycerol a xenobiotic cytidine cytidine a phospholipid a phospholipid dihydroxy-acetone a xenobiotic uridine uridine phospholipid- multidrug phospholipid- phospholipid- translocating resistance transporting transporting aquaglyceroporin p-glycoprotein NT1.1 NT1.2 P-type ATPase protein, ATPase- ATPase 1- (AQP1) (flippase) putative like protein like protein , putative

a phospholipid a phospholipid a phospholipid adenosine adenosine H O 2 thymidine thymidine glycerol a xenobiotic a xenobiotic cytidine cytidine dihydroxy-acetone uridine uridine Copyright © 2006-2012, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne. All Rights Reserved This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.