Multiple Linear Regression & General Linear Model in R
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Understanding Linear and Logistic Regression Analyses
EDUCATION • ÉDUCATION METHODOLOGY Understanding linear and logistic regression analyses Andrew Worster, MD, MSc;*† Jerome Fan, MD;* Afisi Ismaila, MSc† SEE RELATED ARTICLE PAGE 105 egression analysis, also termed regression modeling, come). For example, a researcher could evaluate the poten- Ris an increasingly common statistical method used to tial for injury severity score (ISS) to predict ED length-of- describe and quantify the relation between a clinical out- stay by first producing a scatter plot of ISS graphed against come of interest and one or more other variables. In this ED length-of-stay to determine whether an apparent linear issue of CJEM, Cummings and Mayes used linear and lo- relation exists, and then by deriving the best fit straight line gistic regression to determine whether the type of trauma for the data set using linear regression carried out by statis- team leader (TTL) impacts emergency department (ED) tical software. The mathematical formula for this relation length-of-stay or survival.1 The purpose of this educa- would be: ED length-of-stay = k(ISS) + c. In this equation, tional primer is to provide an easily understood overview k (the slope of the line) indicates the factor by which of these methods of statistical analysis. We hope that this length-of-stay changes as ISS changes and c (the “con- primer will not only help readers interpret the Cummings stant”) is the value of length-of-stay when ISS equals zero and Mayes study, but also other research that uses similar and crosses the vertical axis.2 In this hypothetical scenario, methodology. -
Generalized Linear Models
Generalized Linear Models A generalized linear model (GLM) consists of three parts. i) The first part is a random variable giving the conditional distribution of a response Yi given the values of a set of covariates Xij. In the original work on GLM’sby Nelder and Wedderburn (1972) this random variable was a member of an exponential family, but later work has extended beyond this class of random variables. ii) The second part is a linear predictor, i = + 1Xi1 + 2Xi2 + + ··· kXik . iii) The third part is a smooth and invertible link function g(.) which transforms the expected value of the response variable, i = E(Yi) , and is equal to the linear predictor: g(i) = i = + 1Xi1 + 2Xi2 + + kXik. ··· As shown in Tables 15.1 and 15.2, both the general linear model that we have studied extensively and the logistic regression model from Chapter 14 are special cases of this model. One property of members of the exponential family of distributions is that the conditional variance of the response is a function of its mean, (), and possibly a dispersion parameter . The expressions for the variance functions for common members of the exponential family are shown in Table 15.2. Also, for each distribution there is a so-called canonical link function, which simplifies some of the GLM calculations, which is also shown in Table 15.2. Estimation and Testing for GLMs Parameter estimation in GLMs is conducted by the method of maximum likelihood. As with logistic regression models from the last chapter, the generalization of the residual sums of squares from the general linear model is the residual deviance, Dm 2(log Ls log Lm), where Lm is the maximized likelihood for the model of interest, and Ls is the maximized likelihood for a saturated model, which has one parameter per observation and fits the data as well as possible. -
Application of General Linear Models (GLM) to Assess Nodule Abundance Based on a Photographic Survey (Case Study from IOM Area, Pacific Ocean)
minerals Article Application of General Linear Models (GLM) to Assess Nodule Abundance Based on a Photographic Survey (Case Study from IOM Area, Pacific Ocean) Monika Wasilewska-Błaszczyk * and Jacek Mucha Department of Geology of Mineral Deposits and Mining Geology, Faculty of Geology, Geophysics and Environmental Protection, AGH University of Science and Technology, 30-059 Cracow, Poland; [email protected] * Correspondence: [email protected] Abstract: The success of the future exploitation of the Pacific polymetallic nodule deposits depends on an accurate estimation of their resources, especially in small batches, scheduled for extraction in the short term. The estimation based only on the results of direct seafloor sampling using box corers is burdened with a large error due to the long sampling interval and high variability of the nodule abundance. Therefore, estimations should take into account the results of bottom photograph analyses performed systematically and in large numbers along the course of a research vessel. For photographs taken at the direct sampling sites, the relationship linking the nodule abundance with the independent variables (the percentage of seafloor nodule coverage, the genetic types of nodules in the context of their fraction distribution, and the degree of sediment coverage of nodules) was determined using the general linear model (GLM). Compared to the estimates obtained with a simple Citation: Wasilewska-Błaszczyk, M.; linear model linking this parameter only with the seafloor nodule coverage, a significant decrease Mucha, J. Application of General in the standard prediction error, from 4.2 to 2.5 kg/m2, was found. The use of the GLM for the Linear Models (GLM) to Assess assessment of nodule abundance in individual sites covered by bottom photographs, outside of Nodule Abundance Based on a direct sampling sites, should contribute to a significant increase in the accuracy of the estimation of Photographic Survey (Case Study nodule resources. -
The Simple Linear Regression Model
The Simple Linear Regression Model Suppose we have a data set consisting of n bivariate observations {(x1, y1),..., (xn, yn)}. Response variable y and predictor variable x satisfy the simple linear model if they obey the model yi = β0 + β1xi + ǫi, i = 1,...,n, (1) where the intercept and slope coefficients β0 and β1 are unknown constants and the random errors {ǫi} satisfy the following conditions: 1. The errors ǫ1, . , ǫn all have mean 0, i.e., µǫi = 0 for all i. 2 2 2 2. The errors ǫ1, . , ǫn all have the same variance σ , i.e., σǫi = σ for all i. 3. The errors ǫ1, . , ǫn are independent random variables. 4. The errors ǫ1, . , ǫn are normally distributed. Note that the author provides these assumptions on page 564 BUT ORDERS THEM DIFFERENTLY. Fitting the Simple Linear Model: Estimating β0 and β1 Suppose we believe our data obey the simple linear model. The next step is to fit the model by estimating the unknown intercept and slope coefficients β0 and β1. There are various ways of estimating these from the data but we will use the Least Squares Criterion invented by Gauss. The least squares estimates of β0 and β1, which we will denote by βˆ0 and βˆ1 respectively, are the values of β0 and β1 which minimize the sum of errors squared S(β0, β1): n 2 S(β0, β1) = X ei i=1 n 2 = X[yi − yˆi] i=1 n 2 = X[yi − (β0 + β1xi)] i=1 where the ith modeling error ei is simply the difference between the ith value of the response variable yi and the fitted/predicted valuey ˆi. -
Robust Bayesian General Linear Models ⁎ W.D
www.elsevier.com/locate/ynimg NeuroImage 36 (2007) 661–671 Robust Bayesian general linear models ⁎ W.D. Penny, J. Kilner, and F. Blankenburg Wellcome Department of Imaging Neuroscience, University College London, 12 Queen Square, London WC1N 3BG, UK Received 22 September 2006; revised 20 November 2006; accepted 25 January 2007 Available online 7 May 2007 We describe a Bayesian learning algorithm for Robust General Linear them from the data (Jung et al., 1999). This is, however, a non- Models (RGLMs). The noise is modeled as a Mixture of Gaussians automatic process and will typically require user intervention to rather than the usual single Gaussian. This allows different data points disambiguate the discovered components. In fMRI, autoregressive to be associated with different noise levels and effectively provides a (AR) modeling can be used to downweight the impact of periodic robust estimation of regression coefficients. A variational inference respiratory or cardiac noise sources (Penny et al., 2003). More framework is used to prevent overfitting and provides a model order recently, a number of approaches based on robust regression have selection criterion for noise model order. This allows the RGLM to default to the usual GLM when robustness is not required. The method been applied to imaging data (Wager et al., 2005; Diedrichsen and is compared to other robust regression methods and applied to Shadmehr, 2005). These approaches relax the assumption under- synthetic data and fMRI. lying ordinary regression that the errors be normally (Wager et al., © 2007 Elsevier Inc. All rights reserved. 2005) or identically (Diedrichsen and Shadmehr, 2005) distributed. In Wager et al. -
Generalized Linear Models Outline for Today
Generalized linear models Outline for today • What is a generalized linear model • Linear predictors and link functions • Example: estimate a proportion • Analysis of deviance • Example: fit dose-response data using logistic regression • Example: fit count data using a log-linear model • Advantages and assumptions of glm • Quasi-likelihood models when there is excessive variance Review: what is a (general) linear model A model of the following form: Y = β0 + β1X1 + β2 X 2 + ...+ error • Y is the response variable • The X ‘s are the explanatory variables • The β ‘s are the parameters of the linear equation • The errors are normally distributed with equal variance at all values of the X variables. • Uses least squares to fit model to data, estimate parameters • lm in R The predicted Y, symbolized here by µ, is modeled as µ = β0 + β1X1 + β2 X 2 + ... What is a generalized linear model A model whose predicted values are of the form g(µ) = β0 + β1X1 + β2 X 2 + ... • The model still include a linear predictor (to right of “=”) • g(µ) is the “link function” • Wide diversity of link functions accommodated • Non-normal distributions of errors OK (specified by link function) • Unequal error variances OK (specified by link function) • Uses maximum likelihood to estimate parameters • Uses log-likelihood ratio tests to test parameters • glm in R The two most common link functions Log • used for count data η η = logµ The inverse function is µ = e Logistic or logit • used for binary data µ eη η = log µ = 1− µ The inverse function is 1+ eη In all cases log refers to natural logarithm (base e). -
Chapter 2 Simple Linear Regression Analysis the Simple
Chapter 2 Simple Linear Regression Analysis The simple linear regression model We consider the modelling between the dependent and one independent variable. When there is only one independent variable in the linear regression model, the model is generally termed as a simple linear regression model. When there are more than one independent variables in the model, then the linear model is termed as the multiple linear regression model. The linear model Consider a simple linear regression model yX01 where y is termed as the dependent or study variable and X is termed as the independent or explanatory variable. The terms 0 and 1 are the parameters of the model. The parameter 0 is termed as an intercept term, and the parameter 1 is termed as the slope parameter. These parameters are usually called as regression coefficients. The unobservable error component accounts for the failure of data to lie on the straight line and represents the difference between the true and observed realization of y . There can be several reasons for such difference, e.g., the effect of all deleted variables in the model, variables may be qualitative, inherent randomness in the observations etc. We assume that is observed as independent and identically distributed random variable with mean zero and constant variance 2 . Later, we will additionally assume that is normally distributed. The independent variables are viewed as controlled by the experimenter, so it is considered as non-stochastic whereas y is viewed as a random variable with Ey()01 X and Var() y 2 . Sometimes X can also be a random variable. -
Stat 714 Linear Statistical Models
STAT 714 LINEAR STATISTICAL MODELS Fall, 2010 Lecture Notes Joshua M. Tebbs Department of Statistics The University of South Carolina TABLE OF CONTENTS STAT 714, J. TEBBS Contents 1 Examples of the General Linear Model 1 2 The Linear Least Squares Problem 13 2.1 Least squares estimation . 13 2.2 Geometric considerations . 15 2.3 Reparameterization . 25 3 Estimability and Least Squares Estimators 28 3.1 Introduction . 28 3.2 Estimability . 28 3.2.1 One-way ANOVA . 35 3.2.2 Two-way crossed ANOVA with no interaction . 37 3.2.3 Two-way crossed ANOVA with interaction . 39 3.3 Reparameterization . 40 3.4 Forcing least squares solutions using linear constraints . 46 4 The Gauss-Markov Model 54 4.1 Introduction . 54 4.2 The Gauss-Markov Theorem . 55 4.3 Estimation of σ2 in the GM model . 57 4.4 Implications of model selection . 60 4.4.1 Underfitting (Misspecification) . 60 4.4.2 Overfitting . 61 4.5 The Aitken model and generalized least squares . 63 5 Distributional Theory 68 5.1 Introduction . 68 i TABLE OF CONTENTS STAT 714, J. TEBBS 5.2 Multivariate normal distribution . 69 5.2.1 Probability density function . 69 5.2.2 Moment generating functions . 70 5.2.3 Properties . 72 5.2.4 Less-than-full-rank normal distributions . 73 5.2.5 Independence results . 74 5.2.6 Conditional distributions . 76 5.3 Noncentral χ2 distribution . 77 5.4 Noncentral F distribution . 79 5.5 Distributions of quadratic forms . 81 5.6 Independence of quadratic forms . 85 5.7 Cochran's Theorem . -
The Conspiracy of Random Predictors and Model Violations Against Classical Inference in Regression 1 Introduction
The Conspiracy of Random Predictors and Model Violations against Classical Inference in Regression A. Buja, R. Berk, L. Brown, E. George, E. Pitkin, M. Traskin, K. Zhang, L. Zhao March 10, 2014 Dedicated to Halbert White (y2012) Abstract We review the early insights of Halbert White who over thirty years ago inaugurated a form of statistical inference for regression models that is asymptotically correct even under \model misspecification.” This form of inference, which is pervasive in econometrics, relies on the \sandwich estimator" of standard error. Whereas the classical theory of linear models in statistics assumes models to be correct and predictors to be fixed, White permits models to be \misspecified” and predictors to be random. Careful reading of his theory shows that it is a synergistic effect | a \conspiracy" | of nonlinearity and randomness of the predictors that has the deepest consequences for statistical inference. It will be seen that the synonym \heteroskedasticity-consistent estimator" for the sandwich estimator is misleading because nonlinearity is a more consequential form of model deviation than heteroskedasticity, and both forms are handled asymptotically correctly by the sandwich estimator. The same analysis shows that a valid alternative to the sandwich estimator is given by the \pairs bootstrap" for which we establish a direct connection to the sandwich estimator. We continue with an asymptotic comparison of the sandwich estimator and the standard error estimator from classical linear models theory. The comparison shows that when standard errors from linear models theory deviate from their sandwich analogs, they are usually too liberal, but occasionally they can be too conservative as well. -
Iterative Approaches to Handling Heteroscedasticity with Partially Known Error Variances
International Journal of Statistics and Probability; Vol. 8, No. 2; March 2019 ISSN 1927-7032 E-ISSN 1927-7040 Published by Canadian Center of Science and Education Iterative Approaches to Handling Heteroscedasticity With Partially Known Error Variances Morteza Marzjarani Correspondence: Morteza Marzjarani, National Marine Fisheries Service, Southeast Fisheries Science Center, Galveston Laboratory, 4700 Avenue U, Galveston, Texas 77551, USA. Received: January 30, 2019 Accepted: February 20, 2019 Online Published: February 22, 2019 doi:10.5539/ijsp.v8n2p159 URL: https://doi.org/10.5539/ijsp.v8n2p159 Abstract Heteroscedasticity plays an important role in data analysis. In this article, this issue along with a few different approaches for handling heteroscedasticity are presented. First, an iterative weighted least square (IRLS) and an iterative feasible generalized least square (IFGLS) are deployed and proper weights for reducing heteroscedasticity are determined. Next, a new approach for handling heteroscedasticity is introduced. In this approach, through fitting a multiple linear regression (MLR) model or a general linear model (GLM) to a sufficiently large data set, the data is divided into two parts through the inspection of the residuals based on the results of testing for heteroscedasticity, or via simulations. The first part contains the records where the absolute values of the residuals could be assumed small enough to the point that heteroscedasticity would be ignorable. Under this assumption, the error variances are small and close to their neighboring points. Such error variances could be assumed known (but, not necessarily equal).The second or the remaining portion of the said data is categorized as heteroscedastic. Through real data sets, it is concluded that this approach reduces the number of unusual (such as influential) data points suggested for further inspection and more importantly, it will lowers the root MSE (RMSE) resulting in a more robust set of parameter estimates. -
Bayes Estimates for the Linear Model
Bayes Estimates for the Linear Model By D. V. LINDLEY AND A. F. M. SMITH University College, London [Read before the ROYAL STATISTICAL SOCIETY at a meeting organized by the RESEARCH SECTION on Wednesday, December 8th, 1971, Mr M. J. R. HEALY in the Chair] SUMMARY The usual linear statistical model is reanalyzed using Bayesian methods and the concept of exchangeability. The general method is illustrated by applica tions to two-factor experimental designs and multiple regression. Keywords: LINEAR MODEL; LEAST SQUARES; BAYES ESTIMATES; EXCHANGEABILITY; ADMISSIBILITY; TWO-FACTOR EXPERIMENTAL DESIGN; MULTIPLE REGRESSION; RIDGE REGRESSION; MATRIX INVERSION. INTRODUCTION ATIENTION is confined in this paper to the linear model, E(y) = Ae, where y is a vector of observations, A a known design matrix and e a vector of unknown para meters. The usual estimate of e employed in this situation is that derived by the method of least squares. We argue that it is typically true that there is available prior information about the parameters and that this may be exploited to find improved, and sometimes substantially improved, estimates. In this paper we explore a particular form of prior information based on de Finetti's (1964) important idea of exchangeability. The argument is entirely within the Bayesian framework. Recently there has been much discussion of the respective merits of Bayesian and non-Bayesian approaches to statistics: we cite, for example, the paper by Cornfield (1969) and its ensuing discussion. We do not feel that it is necessary or desirable to add to this type of literature, and since we know of no reasoned argument against the Bayesian position we have adopted it here. -
Lecture 14 Multiple Linear Regression and Logistic Regression
Lecture 14 Multiple Linear Regression and Logistic Regression Fall 2013 Prof. Yao Xie, [email protected] H. Milton Stewart School of Industrial Systems & Engineering Georgia Tech H1 Outline • Multiple regression • Logistic regression H2 Simple linear regression Based on the scatter diagram, it is probably reasonable to assume that the mean of the random variable Y is related to X by the following simple linear regression model: Response Regressor or Predictor Yi = β0 + β1X i + εi i =1,2,!,n 2 ε i 0, εi ∼ Ν( σ ) Intercept Slope Random error where the slope and intercept of the line are called regression coefficients. • The case of simple linear regression considers a single regressor or predictor x and a dependent or response variable Y. H3 Multiple linear regression • Simple linear regression: one predictor variable x • Multiple linear regression: multiple predictor variables x1, x2, …, xk • Example: • simple linear regression property tax = a*house price + b • multiple linear regression property tax = a1*house price + a2*house size + b • Question: how to fit multiple linear regression model? H4 JWCL232_c12_449-512.qxd 1/15/10 10:06 PM Page 450 450 CHAPTER 12 MULTIPLE LINEAR REGRESSION 12-2 HYPOTHESIS TESTS IN MULTIPLE 12-4 PREDICTION OF NEW LINEAR REGRESSION OBSERVATIONS 12-2.1 Test for Significance of 12-5 MODEL ADEQUACY CHECKING Regression 12-5.1 Residual Analysis 12-2.2 Tests on Individual Regression 12-5.2 Influential Observations Coefficients and Subsets of Coefficients 12-6 ASPECTS OF MULTIPLE REGRESSION MODELING 12-3 CONFIDENCE