Rapid Flow-Based Peptide Synthesis The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation Simon, Mark D., Patrick L. Heider, Andrea Adamo, Alexander A. Vinogradov, Surin K. Mong, Xiyuan Li, Tatiana Berger, et al. “Rapid Flow-Based Peptide Synthesis.” ChemBioChem 15, no. 5 (March 11, 2014): 713–720. As Published http://dx.doi.org/10.1002/cbic.201300796 Publisher Wiley Blackwell Version Author's final manuscript Citable link http://hdl.handle.net/1721.1/96181 Terms of Use Creative Commons Attribution-Noncommercial-Share Alike Detailed Terms http://creativecommons.org/licenses/by-nc-sa/4.0/ NIH Public Access Author Manuscript Chembiochem. Author manuscript; available in PMC 2015 March 21. NIH-PA Author ManuscriptPublished NIH-PA Author Manuscript in final edited NIH-PA Author Manuscript form as: Chembiochem. 2014 March 21; 15(5): 713–720. doi:10.1002/cbic.201300796. Rapid Flow-Based Peptide Synthesis Mark D. Simona, Patrick L. Heiderb, Andrea Adamob, Alexander A. Vinogradova, Surin K. Monga, Xiyuan Lia, Tatiana Bergera, Rocco L. Policarpoa, Chi Zhanga, Yekui Zoua, Xiaoli Liaoa, Alexander M. Spokoynya, Prof Klavs F. Jensenb, and Prof Bradley L. Pentelutea Bradley L. Pentelute:
[email protected] aDepartment of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States bDepartment of Chemical Engeneering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States Abstract A flow-based solid phase peptide synthesis methodology that enables the incorporation of an amino acid residue every 1.8 minutes under automatic control, or every three minutes under manual control, is described.