N E U R O S C I E N C E • B I O L O G I C a L C H E M I S T R Y • C a N C E R B I O L O G Y • C E L L Regulation • Genet

Total Page:16

File Type:pdf, Size:1020Kb

N E U R O S C I E N C E • B I O L O G I C a L C H E M I S T R Y • C a N C E R B I O L O G Y • C E L L Regulation • Genet NEUROSCIENCE • biological chemistry • cancer biology • cell regulation • genetics and development • immunology • integrative biology • molecular biophysics • molecular microbiology UTSOUTHWESTERNGRADUATESCHOOLOFBIOMEDICALSCIENCES NEUROSCIENCE Joel Elmquist, Professor D.V.M., Ph.D., Iowa State University, 1992, 1993 I CHAIR,GRADUATEPROGRAM Functional neuroanatomy of the mammalian Ege T. Kavalali, Ph.D. hypothalamus. I DEGREEOFFERED Matthew Goldberg, Assistant Professor Doctor of Philosophy Ph.D., Yale University, 1998 Molecular biology of Parkinson’s disease. FACULTY AND RESEARCH INTERESTS Carla Green, Professor Leon Avery, Professor Ph.D., University of Kansas Medical Center, 1991 Ph.D., Stanford University, 1983 Molecular mechanisms of circadian rhythms and how they control metabolism. Neurogenetics of Caenorhabditis elegans. Robert Greene, Professor Ilya B. Bezprozvanny, Professor Ph.D., George Washington University, 1982; Ph.D., Institute of Cytology, Russian Academy of M.D., University of Maryland, 1983 Sciences, 1992 Control and function of sleep/wake states; system Structure, function and modulation of calcium mechanisms of NMDA hypofunction-related cognitive channels. defects. James A. Bibb, Associate Professor Mark J. Henkemeyer, Associate Professor Ph.D., State University of New York at Stony Ph.D., University of Wisconsin, Madison, 1990 Brook, 1994 Molecular biology of axon guidance. Signal transduction in the nervous system, with emphasis on the biochemistry and neuropharmacology P. Robin Hiesinger, Assistant Professor of protein phosphorylation/dephosphorylation. Ph.D., Albert-Ludwigs University, Freiburg, Stephen C. Cannon, Professor Germany, 2000 M.D., Ph.D., Johns Hopkins University, 1986 Neurogenetics; brain wiring/synaptic specification; synapse function/neurotransmitter-release membrane How ion channels regulate electrical excitability of cells fusion; computational approaches to 4-D visualization and how defects in these channels lead to human and simulation. disease. Donald W. Hilgemann, Professor Roberto Coppari, Assistant Professor Ph.D., University of Tübingen, Germany, 1980 Ph.D., University of Marche, Italy, 2002 Function and regulation of membrane transporters; Cellular mechanisms and neuronal pathways electrophysiology; biophysics of ion pumps and controlling glucose and energy homeostasis. channels. Christopher Cowan, Assistant Professor Jenny Hsieh, Assistant Professor Ph.D., Baylor College of Medicine, 1998 Ph.D., Johns Hopkins University, 2000 Molecular biology of axon guidance. Neural stem-cell biology; chromatin remodeling. Amelia Eisch, Assistant Professor Kimberly M. Huber, Associate Professor Ph.D., University of California, irvine, 1997 Ph.D., University of Texas Graduate School of Function of adult neurogenesis in the brain. Biomedical Sciences at Houston, 1995 Jeffrey Elliott, Professor Physiology and cellular mechanisms of synaptic M.D., Washington University, St. Louis, 1988 plasticity. Molecular and cellular basis for function of the ALS Qui-Xing Jiang, Assistant Professor disease gene SOD1. Ph.D., Yale University, 2002 Elucidating the structural basis of the function of ion channels and other macromolecular complexes. 90 2 0 0 9 – 2 0 1 2 NEUROSCIENCE Jane E. Johnson, Professor Juan M. Pascual, Assistant Professor Ph.D., University of Washington, 1988 M.D., Universidad de Granada, Spain, 1990; Molecular biology of mammalian neural development. Ph.D., Baylor College of Medicine, 1995 Animal and cellular models of neurogenetic disorders; Rolf H. Joho, Associate Professor synaptic transmission in experimental epilepsies; Ph.D., University of Zürich, Switzerland, 1977 disorders of brain energy metabolism. Molecular and cellular neurobiology; structure/function studies of ion channel proteins. Andrew Pieper, Assistant Professor M.D., Ph.D., Johns Hopkins University, 2001 Ege T. Kavalali, Associate Professor Molecular mechanisms of neuropsychiatric disease. Ph.D., Rutgers University, 1995 Molecular physiology of neurotransmission in the Craig Powell, Assistant Professor central nervous system. M.D., Ph.D., Baylor College of Medicine, 1994 Molecular and cellular mechanisms of cognition with Helmut J. Krämer, Associate Professor an emphasis on learning and memory. Ph.D., University of Cologne, Germany, 1989 Genetic dissection of endocytic trafficking in Janine Prange-Kiel, Assistant Professor Drosophila. Ph.D., University of Tuebingen, Germany, 1998 Regulation of hippocampal aromatase expression and Shuxin Li, Assistant Professor its impact on synaptic plasticity; the role of aromatase M.D., Henan Medical University, 1986; Ph.D., in Alzheimer’s disease. University of Ottawa, 2000 Axonal regeneration in the central nervous system; cell José Rizo-Rey, Professor death and neuronal survival; spinal cord injury. Ph.D., University of Barcelona, Spain, 1988 Structural analysis by NMR of proteins involved in Weichun Lin, Assistant Professor calcium-triggered synaptic vesicle exocytosis. Ph.D., State University of New York, 1996 Developmental neurobiology. Adrian Rothenfluh, Assistant Professor Ph.D., Rockefeller University, 1999 Qing Richard Lu, Assistant Professor Genetics and neurobiology of behavioral responses to Ph.D., Rutgers University Robert Wood Johnson drugs of abuse in the fruit fly. Medical School, 1997 Differentiation mechanisms in the mammalian central David W. Self, Associate Professor nervous system: gliogenesis as a model. Ph.D., University of California, Irvine, 1992 Neurobiology of motivational systems and drug Colleen McClung, Assistant Professor addiction. Ph.D., University of Virginia, 2001 Molecular mechanisms of mood disorders and drug Dean P. Smith, Associate Professor addiction. M.D., University of Utah, 1986; Ph.D., University of California, San Diego, 1992 Lisa Monteggia, Assistant Professor Molecular biology of sensory transduction in Drosophila. Ph.D., Chicago Medical School, 1998 Elucidating antidepressant efficacy; a functional Joe Takahashi, Professor molecular and behavioral approach to autism-spectrum Ph.D., University of Oregon, 1981 disorders; cellular basis of psychiatric disorders. Molecular and genetic analysis of the mammalian circadian clock system. Luis F. Parada, Professor Ph.D., Massachusetts Institute of Technology, Carol A. Tamminga, Professor 1985 M.D., Vanderbilt University Medical School, 1971 The role of proto-oncogenes in vertebrate development; Role of the NMDA-sensitive glutamate system in the trk receptors and neurotropins. pathophysiology of schizophrenia, especially in the hippocampus. 2 0 0 9 – 2 0 1 2 91 UTSOUTHWESTERNGRADUATESCHOOLOFBIOMEDICALSCIENCES Jonathan Terman, Assistant Professor CURRICULUM Ph.D., Ohio State University, 1997 Axonal growth and guidance; neuronal connectivity; Neurobiology is a field defined not by a spe- axonal regeneration. cific intellectual approach or experimental technique but by its subject matter: the cells of Jiang Wu, Assistant Professor the nervous, sensory and muscular systems. Ph.D., University of Texas at Austin, 2001 Because of the variety of methods that must be Chromatin regulation of neural development; neural brought to bear in studies of these systems, the stem-cell differentiation; activity-dependent gene optimal training for a career in neurobiological expression. research includes an in-depth exposure to the Masashi Yanagisawa, Professor principles of biochemistry, biophysics, cell and M.D., Ph.D., University of Tsukuba, Japan, 1985, molecular biology, developmental biology, genet- 1988 ics, immunology, pharmacology, and physiology, Identification and characterization of new neuropep- as well as behavioral neuroscience. tides that regulate vital functions such as sleep, appetite and blood pressure. I CORECOURSE Gang Yu, Associate Professor By providing a solid background in the above Ph.D., University of Calgary, Canada, 1996 areas, the first-year Core Course offers Molecular mechanisms of Alzheimer’s disease and appropriate training for first-year students who neuronal signaling. elect to join the Neuroscience Graduate Program. The first-year course also provides 15 hours of OBJECTIVES course credit toward the minimum 24 hours required for graduation. he Neuroscience Graduate Program focuses T I LABORATORYROTATIONS on cellular and molecular neurobiology. Topics of particular interest include synaptic First-year students participate in three laboratory physiology and synaptic plasticity; membrane rotations. Insofar as possible, students with an biophysics, especially receptors and ion channels; interest in neurobiology should seek rotations neuronal organelle traffic, particularly the bio- that expose them to a wide variety of technical genesis and exo- and endocytosis of synaptic vesi- approaches, including anatomy, behavior, bio- cles; neurogenetics of invertebrates and vertebrates; chemistry, biophysics, cell biology, genetics, development of neural systems; and molecular molecular biology and physiology. At the end of and cellular basis of complex behavior. the first year of study, students choose a mentor for dissertation research. SPECIAL REQUIREMENTS FOR ADMISSION I ADVANCEDTOPICSIN tudents wishing to join the Neuroscience S NEUROSCIENCE Graduate Program must be enrolled in the Division of Basic Science and be in good standing Each student in the Neuroscience Graduate academically. Usually students seek enrollment in Program is required to accrue at least nine hours the program toward the end of their first year of of credit from the advanced courses offered with- study following
Recommended publications
  • Faculty Mentor List Basic Science Faculty Mentors 1. Joseph
    Faculty Mentor List Basic Science faculty mentors 1. Joseph Takahashi, Ph.D. Professor and Chair, Department of Neuroscience [email protected] Research Statement: The long-term goals of the Takahashi laboratory are to understand the molecular and genetic basis of circadian rhythms in mammals and to utilize forward genetic approaches in the mouse as a tool for gene discovery for complex behavior. We have focused our attention in three areas: 1) identification of circadian clock genes and assignment of their function in the molecular mechanism of the circadian pacemaker; 2) analysis of central and peripheral circadian oscillators using real-time circadian reporters; and 3) identification of genes defined by mutations isolated in the large-scale mutagenesis screens we have conducted on neural and behavioral phenotypes including psychostimulant responses and contextual and cue dependent fear conditioning. Recently, we have focused on the structural biology of circadian clock proteins and on genomewide analysis of transcription factor binding and gene expression using next generation sequencing methods. A comprehensive global analysis of circadian transcription factor binding in the mouse liver has been completed in which all core components of the clock gene pathway have been interrogated. In addition, we have also analyzed the genome-wide regulation of nascent transcription, RNA polymerase II occupancy and epigenomic regulation of chromatin by the circadian clock. We have recently identified genes involved in cocaine responsiveness using forward genetic approaches. My laboratory has demonstrated a successful record of research productivity and training in circadian biology, mammalian genetics, genomics and molecular biology. 1. Huang, N, Y Chelliah, Y Shan, CA Taylor, S-H Yoo, C Partch, CB Green, H Zhang, JS Takahashi 2012 Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex.
    [Show full text]
  • CURRICULUM VITAE Joseph S. Takahashi Howard Hughes Medical
    CURRICULUM VITAE Joseph S. Takahashi Howard Hughes Medical Institute Department of Neuroscience University of Texas Southwestern Medical Center 5323 Harry Hines Blvd., NA4.118 Dallas, Texas 75390-9111 (214) 648-1876, FAX (214) 648-1801 Email: [email protected] DATE OF BIRTH: December 16, 1951 NATIONALITY: U.S. Citizen by birth EDUCATION: 1981-1983 Pharmacology Research Associate Training Program, National Institute of General Medical Sciences, Laboratory of Clinical Sciences and Laboratory of Cell Biology, National Institutes of Health, Bethesda, MD 1979-1981 Ph.D., Institute of Neuroscience, Department of Biology, University of Oregon, Eugene, Oregon, Dr. Michael Menaker, Advisor. Summer 1977 Hopkins Marine Station, Stanford University, Pacific Grove, California 1975-1979 Department of Zoology, University of Texas, Austin, Texas 1970-1974 B.A. in Biology, Swarthmore College, Swarthmore, Pennsylvania PROFESSIONAL EXPERIENCE: 2013-present Principal Investigator, Satellite, International Institute for Integrative Sleep Medicine, World Premier International Research Center Initiative, University of Tsukuba, Japan 2009-present Professor and Chair, Department of Neuroscience, UT Southwestern Medical Center 2009-present Loyd B. Sands Distinguished Chair in Neuroscience, UT Southwestern 2009-present Investigator, Howard Hughes Medical Institute, UT Southwestern 2009-present Professor Emeritus of Neurobiology and Physiology, and Walter and Mary Elizabeth Glass Professor Emeritus in the Life Sciences, Northwestern University
    [Show full text]
  • An Evolutionary Hotspot Defines Functional Differences Between
    ARTICLE DOI: 10.1038/s41467-018-03503-6 OPEN An evolutionary hotspot defines functional differences between CRYPTOCHROMES Clark Rosensweig1,6, Kimberly A. Reynolds2,3, Peng Gao1, Isara Laothamatas1, Yongli Shan1, Rama Ranganathan2,3,4,7, Joseph S. Takahashi 1,5 & Carla B. Green1 Mammalian circadian clocks are driven by a transcription/translation feedback loop com- posed of positive regulators (CLOCK/BMAL1) and repressors (CRYPTOCHROME 1/2 1234567890():,; (CRY1/2) and PER1/2). To understand the structural principles of regulation, we used evo- lutionary sequence analysis to identify co-evolving residues within the CRY/PHL protein family. Here we report the identification of an ancestral secondary cofactor-binding pocket as an interface in repressive CRYs, mediating regulation through direct interaction with CLOCK and BMAL1. Mutations weakening binding between CLOCK/BMAL1 and CRY1 lead to acceleration of the clock, suggesting that subtle sequence divergences at this site can modulate clock function. Divergence between CRY1 and CRY2 at this site results in distinct periodic output. Weaker interactions between CRY2 and CLOCK/BMAL1 at this pocket are strengthened by co-expression of PER2, suggesting that PER expression limits the length of the repressive phase in CRY2-driven rhythms. Overall, this work provides a model for the mechanism and evolutionary variation of clock regulatory mechanisms. 1 Department of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. 2 Department of Biophysics, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA. 3 The Green Center for Systems Biology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA.
    [Show full text]
  • Roedunet 2006
    Rhythmic Degradation Explains and Unifies Circadian Transcriptome and Proteome Data S. Lück1 2, K. Thurley1, P. F.Thaben1, P. O. Westermark1 In a second approach we expand the view on a molecule's Short Abstract — In many mammalian tissues, 10% of all life and include a measure of a molecule's age. We address transcripts display a 24-hour rhythm in abundance. These the question in which cases there is an advantage of abundane profiles are thought to be driven by the “circadian rhythmic instead of constant degradation of long-lived clock”, a regulatory network of transcription factors. proteins when they accumulate oxidative damage. Secondly, in a collaboration with Carla Green we use the same model Recent studies have uncovered that these transcripts to analyze sequencing data of poly(A) tails of mRNA in experience a widespread circadian post-transcriptional order to identify bottle necks in (rhythmic) mRNA regulation. Using an ODE-model with time-dependent rates degradation. we have recently shown that the assumption of rhythmic half- lives can explain the mismatch of measured peaks of pre- mRNA and mRNA. The model predicts that peak phases of ca. REFERENCES 30% of oscillatory mRNA in mouse liver and fly brain are determined by rhythmic degradation. An expansion to a PDE [1] Zhang EE, Kay SA (2010) “Clocks not winding down”, Nature 11 764- allows us to include a measure for the molecule's age, and thus 776 study oxidative protein damage or polyA-tail shortening. [2] Menet JS, et al. (2012) “Nascent-Seq reveals novel features of mouse circadian transcriptional regulation”, eLife 1:e0001 [3] Mauvoisin D, et al.
    [Show full text]
  • Agenda Final
    Janelia Farm Conference: Circadian Clocks: Mechanisms, Coordination, and Physiology Sunday, March 4th 3:00 pm Check-in 6:00 pm Reception (Lobby) 7:00 pm Dinner 8:00 pm Keynote Talk: Takao Kondo, Nagoya University Circadian pacemaker of cyanobacteria by intramolecular feedback of KaiC ATPase 9:00 pm Refreshments available at Bob’s Pub Updated 02/03/12 Janelia Farm Conference: Circadian Clocks: Mechanisms, Coordination, and Physiology Monday, March 5th 7:30 am Breakfast (service ends at 8:45 am) 9:00 am Session 1 Chair: Joe Takahashi 9:00 am Michael Brunner, University of Heidelberg A global transcription repressor links metabolism and the circadian clock of Neurospora 9:30 am Deborah Bell-Pedersen, Texas A&M University Global gene regulatory networks control circadian output in neurospora 10:00 am Jay Dunlap, Dartmouth Medical School Genetic and molecular dissection of the neurospora circadian oscillatory system 10:30 am Break 11:00 am Session 2 Chair: Martha Merrow 11:00 am Susan S. Golden, University of California, San Diego Signal transduction into and out of the cyanobacterial circadian oscillator 11:30 am Erin O'Shea, HHMI/Harvard University Timekeeping by a three-protein circadian clock 12:00 pm Andrew Oates, Max Planck Institute of Molecular Cell Biology and Genetics Mechanism and coordination of oscillating cells in the embryo's segmentation clock 12:30 pm Lunch 2:00 pm Session 3 Chair: Michael Rosbash 2:00 pm Steve A. Kay, University of California, San Diego Large scale discovery approaches to understanding circadian networks
    [Show full text]
  • SRBR 2004 Program Book
    Ninth Meeting Society for Research on Biological Rhythms Program and Abstracts SRS/SRBR June 23, 2004 SRBR June 24–26, 2004 Whistler Resort • Whistler, British Columbia SOCIETY FOR RESEARCH ON BIOLOGICAL RHYTHMS i Executive Committee Editorial Board Ralph E. Mistleberger Simon Fraser University Steven Reppert, President Serge Daan University of Massachusetts Medical University of Groningen School Larry Morin SUNY, Stony Brook Bruce Goldman William Schwartz, President-Elect University of Connecticut University of Massachusetts Medical Hitoshi Okamura Kobe University School of Medicine School Terry Page Vanderbilt University Carla Green, Secretary Steven Reppert University of Massachusetts Medical University of Virginia Ueli Schibler School University of Geneva Fred Davis, Treasurer Mark Rollag Northeastern University Michael Terman Uniformed Services University Columbia University Helena Illnerova, Member-at-Large Benjamin Rusak Czech. Academy of Sciences Advisory Board Dalhousie University Takao Kondo, Member-at-Large Timothy J. Bartness Nagoya University Georgia State University Laura Smale Michigan State University Anna Wirz-Justice, Member-at-Large Vincent M. Cassone Centre for Chronobiology Texas A & M University Rae Silver Columbia University Journal of Biological Russell Foster Rhythms Imperial College of Science Martin Straume University of Virginia Jadwiga M. Giebultowicz Editor-in-Chief Oregon State University Elaine Tobin Martin Zatz University of California, Los Angeles National Institute of Mental Health Carla Green University of Virginia Fred Turek Associate Editors Northwestern University Eberhard Gwinner Josephine Arendt Max Planck Institute G.T.J. van der Horst University of Surrey Erasmus University Paul Hardin Michael Hastings University of Houston David R. Weaver MRC, Cambridge University of Massachusetts Medical Helena Illerova Center Ken-Ichi Honma Czech.
    [Show full text]
  • Impact of Temporary Assistance for Needy Families on Poverty Rates in Kansas Carla Green Walden University
    Walden University ScholarWorks Walden Dissertations and Doctoral Studies Walden Dissertations and Doctoral Studies Collection 2019 Impact of Temporary Assistance for Needy Families on Poverty Rates in Kansas Carla Green Walden University Follow this and additional works at: https://scholarworks.waldenu.edu/dissertations Part of the Public Policy Commons This Dissertation is brought to you for free and open access by the Walden Dissertations and Doctoral Studies Collection at ScholarWorks. It has been accepted for inclusion in Walden Dissertations and Doctoral Studies by an authorized administrator of ScholarWorks. For more information, please contact [email protected]. Walden University College of Social and Behavioral Sciences This is to certify that the doctoral dissertation by Carla Green has been found to be complete and satisfactory in all respects, and that any and all revisions required by the review committee have been made. Review Committee Dr. Gregory Campbell, Committee Chairperson, Public Policy and Administration Faculty Dr. Ross Alexander, Committee Member, Public Policy and Administration Faculty Dr. Victoria Landu-Adams, University Reviewer, Public Policy and Administration Faculty Chief Academic Officer Eric Riedel, Ph.D. Walden University 2019 Abstract Impact of Temporary Assistance for Needy Families on Poverty Rates in Kansas by Carla Green MA, Baker University, 2007 BS, Kansas State University, 2006 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Public
    [Show full text]
  • Circadian Control of Mrna Polyadenylation Dynamics Regulates Rhythmic Protein Expression
    Downloaded from genesdev.cshlp.org on September 29, 2021 - Published by Cold Spring Harbor Laboratory Press Circadian control of mRNA polyadenylation dynamics regulates rhythmic protein expression Shihoko Kojima, Elaine L. Sher-Chen, and Carla B. Green1 Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA Poly(A) tails are 39 modifications of eukaryotic mRNAs that are important in the control of translation and mRNA stability. We identified hundreds of mouse liver mRNAs that exhibit robust circadian rhythms in the length of their poly(A) tails. Approximately 80% of these are primarily the result of nuclear adenylation coupled with rhythmic transcription. However, unique decay kinetics distinguish these mRNAs from other mRNAs that are transcribed rhythmically but do not exhibit poly(A) tail rhythms. The remaining 20% are uncoupled from transcription and exhibit poly(A) tail rhythms even though the steady-state mRNA levels are not rhythmic. These are under the control of rhythmic cytoplasmic polyadenylation, regulated at least in some cases by cytoplasmic polyadenylation element-binding proteins (CPEBs). Importantly, we found that the rhythmicity in poly(A) tail length is closely correlated with rhythmic protein expression, with a several-hour delay between the time of longest tail and the time of highest protein level. Our study demonstrates that the circadian clock regulates the dynamic polyadenylation status of mRNAs, which can result in rhythmic protein expression independent of the steady-state levels of the message. [Keywords: circadian; polyadenylation; deadenylation; post-transcriptional mechanism] Supplemental material is available for this article. Received October 15, 2012; revised version accepted November 12, 2012.
    [Show full text]
  • UTSW Graduate School Catalog: Neuroscience
    NEUROSCIENCE • biological chemistry • biomedical engineering • cancer biology • cell regulation • genetics and development • immunology • integrative biology • molecular biophysics • molecular microbiology UT SOUTHWESTERN GRADUATE SCHOOL OF BIOMEDICAL SCIENCES NEUROSCIENCE NEUROSCIENCE Jennifer Hsieh Ann Stowe Ph.D., Johns Hopkins University, 2000 Ph.D., University of Kansas Medical Center, 2006 I CHAIR, GRADUATE PROGRAM Kimberly M. Huber Jiang Wu Ege T. Kavalali, Ph.D. Ph.D., UT Graduate School of Biomedical Sciences Ph.D., UT Austin, 2001 I DEGREE OFFERED at Houston, 1995 Chun-Li Zhang Doctor of Philosophy Weichun Lin Ph.D., UT Southwestern Medical Center, 2002 Ph.D., State University of New York, 1996 FACULTY Qing “Richard” Lu OBJECTIVES I PROFESSORS Ph.D., Rutgers University Robert Wood Johnson Medical School, 1997 he Neuroscience Graduate Program focuses Ilya B. Bezprozvanny T on cellular and molecular neurobiology. Ph.D., Institute of Cytology, Russian Academy of Lisa Monteggia Topics of particular interest include synaptic Sciences, 1992 Ph.D., Chicago Medical School, 1998 physiology and synaptic plasticity; membrane Stephen C. Cannon Craig Powell biophysics, especially receptors and ion channels; M.D., Ph.D., Johns Hopkins University, 1986 M.D., Ph.D., Baylor College of Medicine, 1994 neuronal organelle traffic, particularly the Jeffrey Elliott Jonathan Terman biogenesis and exo- and endocytosis of synaptic M.D., Washington University, St. Louis, 1988 Ph.D., Ohio State University, 1997 vesicles; neurogenetics of invertebrates and
    [Show full text]
  • Nangle Et Al. 2014 1 1 2 3 4 5 6 Molecular Assembly of the Period-Cryptochrome Circadian Transcriptional Repressor Complex 7
    Nangle et al. 2014 1 2 3 4 5 6 7 Molecular Assembly of the Period-Cryptochrome Circadian Transcriptional Repressor Complex 8 9 Shannon N. Nangle1, ‡, Clark Rosensweig3, ‡, Nobuya Koike5, Hajime Tei6, Joseph S. Takahashi3,4,*, Carla B. 10 Green3,* & Ning Zheng1,2,* 11 12 13 14 15 1Department of Pharmacology and 2Howard Hughes Medical Institute, Box 357280, University of Washington, 16 Seattle, WA 98195, USA 17 3Department of Neuroscience and 4Howard Hughes Medical Institute, The University of Texas Southwestern 18 Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA 19 5Department of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine 20 Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan 21 6Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Ishikawa, Japan 22 23 ‡ These authors contributed equally to this work. 24 *Correspondence: [email protected], [email protected], [email protected] 25 26 1 Nangle et al. 2014 27 ABSTRACT 28 The mammalian circadian clock is driven by a transcriptional-translational feedback loop, which produces 29 robust 24-hr rhythms. Proper oscillation of the clock depends on the complex formation and cyclic turnover of 30 the Period and Cryptochrome proteins, which together inhibit their own transcriptional activator complex, 31 CLOCK-BMAL1. We determined the crystal structure of the CRY-binding domain (CBD) of PER2 in complex 32 with CRY2 at 2.8 Å resolution. PER2-CBD adopts a highly extended conformation, embracing CRY2 with a 33 sinuous binding mode. Its N-terminal end tucks into CRY adjacent to a large pocket critical for CLOCK- 34 BMAL1 binding, while its C-terminal half flanks the CRY2 C-terminal helix and sterically hinders the 35 recognition of CRY2 by the FBXL3 ubiquitin ligase.
    [Show full text]
  • Community Choice
    RESEARCH HIGHLIGHTS THIS WEEK the synthesis of their protein products. Carla Green and her colleagues at the University of COMMUNITY The most viewed SAMUEL BECK Texas Southwestern Medical CHOICE papers in science Center in Dallas found 237 mouse-liver mRNAs that TAXONOMY show circadian rhythmicity in the number of adenosine Scarce cetaceans catalogued molecules added to the end of mRNAs. The length of this ✪ HIGHLY READ A paper titled “The world’s rarest whale” ‘poly(A) tail’ can affect the on www.cell.com documents the unprecedented beaching stability of the mRNA and, 16 Nov–16 Dec of two spade-toothed beaked whales Billy Krimmel at the ultimately, the amount of (Mesoplodon traversii). University of California, cognate protein produced. Members of this species, which haunt the deepest reaches Davis, and Ian Pearse at Further analysis of five of of the South Pacific Ocean, had been known from only a tiny Cornell University in Ithaca, these mRNAs showed that handful of bones and teeth. A mother and calf stranded in New York, report that sticky, peak poly(A) tail length 2010 are thought to be the first to be seen in the flesh. The hair-like trichomes on preceded a peak in protein adult was about five metres long and patterned in black, white common tarweed (Madia accumulation by 4–8 hours, and grey. Initially misidentified as Gray’s beaked whales elegans) trap small insects. even when the amount of (M. grayi), the rare animals were correctly identified thanks These may function as bait those mRNAs remained to DNA typing by Rochelle Constantine at the University of to attract predatory insects constant.
    [Show full text]
  • SRBR-2018-Program-Book.Pdf
    RESORT MAP D. SHOPPING R R RECREATION KE 5 Beach Shoppe Walkway AL & ACTIVITIES H W to Beach AC 33 Amelia Shoppe 3 Camp Amelia BE TO SPA & SHOPS (Resort P 7 Towel & Activity Hut Guests MEETING 11 Gamers Only) PARKING GARAGE SPACE 13 Hotel Fitness B 9 Azalea Room Center E A Walking Path C 10 Hibiscus Room H P L 12 Live Oak Room A DINING G 14 Oceanview Room Breezeway O 2 Seaglass O & Terrace N 6 Oceanside R D 8 Rum + Tequila . Experience Tram Stop 15 Sunrise Café (Dial “0” to Request) Beach Level Elevators MAGNOLIA CONFERENCE GARDEN CENTER RESORT ENTRANCE BEA CHWO OD RD. BREEZEWAY PORTE COCHERE LOBBY 9 10 33 2 11 TERRACE 12 ADULT POOL 3 5 8 FAMILY POOL 13 15 14 SPLASH 904-261-6161 POOL 6 7 ATLANTIC OCEAN Omni Resort Area Map 11x8.5.indd 4 10/3/16 9:10 AM Amelia Island Conference Center To Oceanside Wing 4 3 Sapelo 2 A B 1 Amelia Ballroom A B C B B Amelia Foyer Cumberland 1 2 8 Flags Patio Ballroom A A Business Cumberland Foyer Center 1 2 3 Conference 1. Talbot 2. Ossabaw To Sunrise Wing A B C Parking Deck Parking D Magnolia Ballroom G F E Magnolia Foyer Magnolia Terrace and Garden Magnolia Terrace SRBR would like to acknowledge the following funding agencies whose grants have contributed to the overall quality and diversity of the meeting. A Special Thanks to the 2018 SRBR Sponsors! Rathaus Glockenspiel Sponsor Cosmo Clock 21 Sponsors Samrat Yantra Sponsors Sponsor Private Donation from the Estate of Ronald J.
    [Show full text]