New GC and Sample Preparation Products for 2016
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297–372 5, 34 Number Volume Volume 34 Number 5 May 2016 www.chromatographyonline.com LCGC NORTH AMERICA NORTH LCGC New GC and Sample Preparation Products for 2016 How to Tackle an Unknown Extracting Peptides from Whole Blood What You Need May 2016 May to Know about LC Pumps WHOSE GC SOURCE CAN BE SERVICED IN LESS THAN 3 MINUTES? Th roughput and uptime are crucial in any environmental monitoring laboratory. is a registered trademark of PerkinElmer, Inc. Which is why PerkinElmer engineered the ® Clarus® SQ 8 GC/MS with a revolutionary SMARTsource™ that can be removed, cleaned, and reassembled in a matt er of minutes. Streamline and simplify your routine applications with the Clarus SQ 8 GC/MS. And enjoy a source of unparalleled precision and productivity. www.perkinelmer.com/gcms ©2016 PerkinElmer,©2016 Inc. 400344_01. All rights reserved. PerkinElmer Wine should ONLY be wine. People trust their wine to be exactly as they expect. Unadulterated, safe, consistent. And not coincidentally, each of the world’s top ten beverage companies trust us to help keep it that way. They know how long it takes to build a brand’s reputation and how quickly one can disappear. So they come to us and our widest instrumentation portfolio on the planet — ion, liquid and gas chromatography, metal analysis, mass spectrometry, discrete analyzers to data management — for accurate, reliable answers no matter where they are in the beverage analysis process. They trust us to help keep their product their product. And equally important, their brand their brand. YOUR BRAND IS EVERYTHING. ThermoFisher.com/BeverageTesting ©2016 Thermo FisherrS Sciecentint ficfi Inc. All rigghtst reserved. Copyrights in and to images and footageae are owned by third partiesas and liccensen ed for limitedd useus only to Thermo Fisher Scientinificfi by Getty Images. All rights reserved. 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UBM SIGN UP FOR FREE AT Americas serves business professionals and consumers in these industries with its portfolio of 91 events, 67 publications and directories, 150 electronic publications and Web sites, as well as www.chromatographyonline.com/ educational and direct marketing products and services. Market leading brands and a commit- ment to delivering innovative, quality products and services enables UBM Americas to “Connect Oleksiy Mark/Getty Images column-subscribe Our Customers With Theirs.” UBM Americas has approximately 1000 employees and currently operates from multiple offices in North America and Europe. TSKgel® HPLC columns have been the standard in the bioseparations industry for over 20 years. TSKgel Butyl-NPR, 2.5 μm and TSKgel UP-SW3000, 2.0 μm columns are an excellent choice for the DAR (drug-to-antibody ratio) analysis and size separation of ADCs. mAb Unconjugated mAb TSKgel Butyl-NPR (Trastuzumab) Delivering baseline resolution, a TSKgel Butyl NPR column enables 0 5101520253035an easy integration and quantification DAR=2 of different drug pay loads in ADC ADC DAR=4 (Trastuzumab drug characterization. conjugated) Detector response (mAU) DAR=6 DAR=0 DAR=8 0 5101520 25 30 35 Retention time (minutes) ADC TSKgel UP-SW3000 (Trastuzumab Monomer drug conjugated) TSKgel UP-SW3000, 2 μm columns Sodium phosphate + IPA offer high resolution for aggregate 0% IPA and monomer analysis of ADCs. Dimer 10% IPA Detector response (mAU) 2.5 3.5 4.5 5.5 Retention time (minutes) These columns are designed for use with both UHPLC and HPLC systems. Order TSKgel HPLC columns today to maximize resolution for ADC analysis! 800-366-4875 TSKgel and Tosoh Bioscience are registered trademarks of Tosoh Corporation. www.tosohbioscience.com 302 LCGC NORTH AMERICA VOLUME 34 NUMBER 5 MAY 2016 www.chromatographyonline.com ® HPLC Columns for Organic Acid Analysis PUBLISHING & SALES 485F US Highway One South, Suite 210, Over 25 years of experience Iselin, NJ 08830 providing high quality polymeric (732) 596-0276 HPLC columns for the analysis Fax: (732) 647-1235 of samples containing carbohydrates and Michael J. Tessalone Vice President/Group Publisher, Pharma/Science Group, organic acids. [email protected] Edward Fantuzzi Benson Publisher, [email protected] polymericTM Stephanie Shaffer East Coast Sales Manager, [email protected] Lizzy Thomas Account Executive, [email protected] EDITORIAL Laura Bush bensonpolymeric.com Editorial Director, 775.356.5755 [email protected] Megan L’Heureux Managing Editor, [email protected] Stephen A. Brown Group Technical Editor, ^KDd,/E'^ [email protected] Cindy Delonas Associate Editor, EsZ,E' [email protected] Ronald E. Majors Column Editor Emeritus Dan Ward Art Director, [email protected] 48$/,7< 5(/,$%,/,7< Rajesh Thangappan Graphic Designer Anne Lavigne Marketing Manager, Et͊ [email protected] Ronda Hughes C.A.S.T. Data and List Information, [email protected] Ρ Wright’s Media <d Reprints, [email protected] Maureen Cannon >ĂŵƉƐΘ^ĞƌǀŝĐĞ Permissions, [email protected] Jesse Singer W,͗ϮϬϭͲϮϯϲͲဓϯϬϬŵĂŝů͗^ŽŶŶƚĞŬΛĂŽů͘ĐŽŵ Production Manager, [email protected] Wendy Bong Audience Development Manager, ǁǁǁ͘ƐŽŶŶƚĞŬ͘ĐŽŵ [email protected]