FRIDAY, APRIL 1 Biochemistry and Molecular

1. ASBMB GRADUATE AND POSTDOCTORAL TRAVEL AWARD PROFESSIONAL NETWORKING EVENT

Special Event

Fri. 5:30 pm—San Diego Convention Center, Room 6A Foyer

Cochaired: C. Heinen and T. O’Connell

Invitation only. Required participation by all Graduate/ Postdoctoral and Graduate Student MAC Supported Travel Award recipients. Follow the conversation: #education

Nutrition

2. ASN SPONSORED SATELLITE PROGRAM: 4. ASN CAROTENOID AND RETINOID A GLOBAL APPROACH TO PERSONALIZED INTERACTIVE GROUP (CARIG) ANNUAL NUTRITION FROM THE TO THE SYMPOSIUM AND BUSINESS MEETING MICROBIOME Special Event ASN Satellite (Sponsored by: CARIG RIS) (Organized and Sponsored by: Herbalife) Fri. 1:00 pm—Hilton San Diego Bayfront, Aqua AB Fri. 8:00 am—Hilton San Diego Bayfront, Indigo D Chaired: S.A. Tanumihardjo Chaired: D. Heber Reception and CARIG Poster Competition to follow in Aqua C

Visit the Exhibits April 3–April 5 Exhibit Hours Sunday – Tuesday 9:00 am – 4:00 pm

1 SATURDAY, APRIL 2 Across Societies

5. CAREER DEVELOPMENT WORKSHOPS 10:00 Negotiation Strategies for Scientists Part 1. D. Behrens. Univ. of California, Berkeley. Workshop 10:30 Understanding Search Committees & Finding Job Announcements. A. Green. Univ. of Sat. 9:00 am—San Diego Convention Center, Exhibit Hall D California, Berkeley. Career Development 11:00 But I Have No Skills!. J. Lombardo. Med. Col. of Wisconsin and Marquette Univ. The following workshops will be held in the EB2016/FASEB 11:00 Beyond the Bench: Preparing for Your Career Transition Career Center. Access to the Career Center is FREE to all in the Life Sciences. J. Tringali. Tringali & Assocs. Inc. registered Experimental Biology 2016 meeting attendees. 1:00 Job Hunting in Biotech Part 1: Finding & Applying for Poster/Platform Presenter Preparation Workshop and Scientist Positions. B. Lindstaedt. UCSF. Practice Lab 1:00 Transforming Your CV/Cover Letter for Industry Positions. N. Saul. UCSF. FASEB MARC Program will sponsor a Poster/Platform 1:00 Negotiation Strategies for Scientists Part 2. D. Behrens. Presenter Preparation Workshop and Practice Lab beginning Univ. of California, Berkeley. Saturday, April 2, to provide FASEB MARC poster/oral 2:00 Networking: A Required Life Skill. H. Adams. H.G. presentation travel award recipients and other interested EB2016 Adams & Assocs. Inc., Norfolk, VA. student/postdoc attendees with an opportunity to practice their 2:30 Job Hunting in Biotech Part 2: Interviewing for Scientist presentations and obtain feedback from designated Workshop Positions. B. Lindstaedt. UCSF. Mentors/Coaches. If you would like to participate in this 2:30 Developing Your Core Message/ “Elevator Pitch”. workshop/practice lab, sign-up onsite at the Career Center J. Lombardo. Med. Col. of Wisconsin and beginning Saturday morning, April 2. First-come, first- Marquette Univ. served. Limited space/session availability. 3:00 Networking: Optimizing Your Time at EB2016. J. 9:00 Networking: Optimizing Your Time at EB2016. J. Tringali. Tringali & Assocs. Inc. Tringali. Tringali & Assocs. Inc. 4:00 Job Hunting in Biotech Part 3: Compensation Negotiation 9:00 Get Up With Something on Your Mind. H. Adams. H.G. for Scientist Positions. B. Lindstaedt. UCSF. Adams & Assocs. Inc., Norfolk, VA. 4:00 Creating Effective CV’s Cover Letters, Research 9:30 How to Choose Your Ideal Career. B. Lindstaedt. UCSF. & Teaching Statements. A. Green. Univ. of California, Berkeley. Anatomy

6. UNLOCKING YOUR POTENTIAL IN ACADEMICS: 7. “ONCE UPON A TIME”: CULTIVATING THE SEIZING OPPORTUNITIES TO SUCCEED WHILE SKILL OF STORY TELLING AVOIDING PITFALLS Symposium Symposium Sat. 10:30 am—San Diego Convention Center, Room 7B Sat. 8:30 am—San Diego Convention Center, Room 7B Chaired: A. Poznanski Chaired: H.W. Lambert Professional Development Professional Development Career Development Career Development 10:30 7.1 The Elements of Story Telling. A. Poznanski. 8:30 Chair’s Introduction. California Northstate Univ. Col. of Med. 8:35 6.1 Finding the Elusive Pathway to Promotion as 10:50 7.2 A Very Short Story: The 6 Minute TED Talk. an Educator. H.W. Lambert, M.J. Zdilla, P.S. Klinkhachorn. J.S. Reidenberg. Icahn Sch. of Med. at Mount Sinai. West Virginia Univ. Sch. of Med. and West Liberty Univ. 11:10 7.3 Your 15 Minutes on the Podium Have Finally 9:00 6.2 Achieving Tenure as a Clinical Researcher. Arrived...J.T. Laitman. Icahn Sch. of Med. at Mount Sinai. K.B. Foreman. Univ. of Utah. 11:30 7.4 60 Minutes of Tension: The Hour Long 9:25 6.3 Strategies for Getting Promoted in a Difficult Research Talk. R. Marcucio. UCSF. Granting Environment. J.A. Guttman. Simon Fraser 11:50 General Discussion. Univ., Canada. 9:50 General Discussion.

2 SATURDAY ANATOMY

8. MORPHOGENESIS AND DIFFERENTIATION OF 2:15 9.6 Implantation of Insulin-Producing Cells from CRANIAL NEURAL CREST AND PLACODES Human Umbilical Cord Blood Mesenchymal Stem Cells in the Liver and Its Potential to Cure Streptozotocin-Induced Symposium : An Animal Model Study. M.A. Eladl, M. El-Sherbiny, A.V. Ranade, H. Gabr. Univ. of Sharjah, United Arab Emirates, Sat. 1:00 pm—San Diego Convention Center, Room 10 Univ. of Mansoura, Egypt, ALMaarefa Col., Saudi Arabia and Cairo Univ. Chaired: S.A. A. Moody S Cell Biology 10. BUILDING THE FUTURE OF HISTOLOGY: A Neurobiology SYNERGY BETWEEN EDUCATORS, CLINICIANS T AND TECHNOLOGY This session was funded in part by an AAA Three-Year Research Meetings Outreach Grant Hybrid Symposium 1:00 8.1 Complex Roles of ADAM Cell Surface Sat. 1:00 pm—San Diego Convention Center, Room 8 Metalloproteases during Cranial Neural Crest Cell Migration. D. Alfandari, G. Abbruzzese, K. Mathavan, H. Cousin. Univ. Chaired: R. Ettarh of Massachusetts Amherst. 1:30 8.2 Self-Organization of Zebrafish Lateral Line Education and Teaching Primordium Morphogenesis and Migration. A. Chitnis, D. Dalle 1:00 10.1 Building LCME-Compliant Histology Teaching Nogare. NICHD, NIH. and Learning for Clinicians. R. Ettarh. Tulane Univ. Sch. 2:00 8.3 Neural Crest-Placode Cell Interactions during of Med. Cranial Ganglia Assembly. L.A. Taneyhill. Univ. of Maryland 1:30 10.2 Integrating Histology in the Medical Curriculum. College Park. D. Bolender. Med. Col. of Wisconsin. 2:00 10.3 Collaboration between Basic Scientists 9. STEM CELLS AND TISSUE ENGINEERING and Clinicians: An Opportunity to Develop a Microanatomy PLATFORM Curriculum to Integrate Curricular Content and Encourage Student Interaction. J.M. McBride. Lerner Col. of Med., Platform Cleveland Clin. 2:15 10.4 The Interrupted Learner – How Students’ Sat. 1:00 pm—San Diego Convention Center, Room 9 Choices to Attend Lectures or Watch Lecture Video Recordings Chaired: M. Dunnwald Influence Learning Outcomes in a Medical Histology Course. M. Hortsch, J. Burk-Rafel, A.H. Zureick, J. Purkiss. Univ. Stem Cells/ Regeneration of Michigan. Tissue Bioengineering 11. BIOLOGICAL ANTHROPOLOGY PLATFORM This session is part of the Stem Cells Mini-Meeting 1:00 9.1 TGFβ Signaling Regulates Decorin and Platform Biglycan Expression and Distribution during Murine Palatal Sat. 1:00 pm—San Diego Convention Center, Room 7B Fusion. K.K.H. Svoboda, I. Ibrahim, M.J. Serrano, L-B. Ruest. Texas A&M Baylor Col. of Dent. Chaired: K. Willmore 1:15 9.2 Matrix Reloaded: Devitalized Cartilage as a Evolution/Anthropology Functional Extracellular Niche to Promote Osteogenesis and Angiogenesis. J.M. Perry, D.M. Poscablo, B.T. Gaston, D.P. Developmental Biology/Morphology Hu, T. Miclau, K.L. Christman, R.S. Marcucio, C.S. Bahney. Emily Middleton is competing as a finalist in the Postdoctoral UCSF and UCSD. Platform Presentation Award 1:30 9.3 Impact of BMP-7 on Cell Migration in the Meniscus. V. Taylor II, I. Hutchinson, K. Danelson, C. 1:00 TBD Ferguson. Wake Forest Med. Ctr. and Hosp. for Spec. Surg., 1:15 11.2 Reconstructing Jaw Adductors in Plesiadapid NY. (1034.17) Plesiadapiforms from Berru, France (Thanetian, ELMA). H. 1:45 9.4 Potential Mechanisms of Action for Exogenous Kristjanson, J.M.G. Perry. Johns Hopkins Univ. Sch. of Med. Ketone Enhancement of Ischemic Wound Healing in Young 1:30 11.3 2D versus 3D Shape Signals of Climatic and Aged Fischer . S.L. Kesl, M. Wu, L.J. Gould, D.P. Adaptations in the Trunk Skeleton of Recent Humans. E.R. D’Agostino. Morsani Col. of Med., Univ. of South Florida. Middleton. Univ. of Missouri-Columbia. (1036.9) 1:45 11.4 New Insights into the Anatomy of the 2:00 9.5 Characterization of Spontaneous Bulbospongiosus Muscle and Its Role in the Composition of the Chondrogenesis during Tail Regeneration of the Leopard Gecko External Anal Sphincter in Humans. M. Hall, J.H. Plochocki, B. (Eublepharis macularius). N. Subramaniam, K. Jacyniak, R.P. Adrian, J.R. Rodriguez-Sosa. Midwestern Univ., AZ. McDonald, M.K. Vickaryous. Univ. of Guelph, Canada. 2:00 11.5 Getting the Shaft?: Investigating Midshaft Location in Immature Femora. C.D. Eleazer, R. Scopa Kelso, F.L. West, L. Williams, R. Stradleigh, A. Shaeffer. Florida Intl. Univ., West Virginia Sch. of Osteo. Med. and Univ. of Tennessee, Knoxville.

3 ANATOMY SATURDAY

2:15 11.1 A Comparative and Phylogenetic Analysis of 14. ALTERNATIVE PRESERVATION TECHNIQUES the Relationship between Facial Orientation and Circumorbital TO MEET THE NEEDS OF TODAY’S STUDENTS Breadths in the Hominoids. E. Leslie, Y. Mehta. Midwestern Univ., IL. Symposium

Sat. 3:00 pm—San Diego Convention Center, Room 8 12. SENSATION MECHANISM OF BODY FLUID FLOW BY PRIMARY CILIA Chaired: M. Sochor Education and Teaching Symposium 3:00 14.1 Pride, Protectionism, and Prejudice Sat. 3:00 pm—San Diego Convention Center, Room 10 Overcoming Hurdles in Setting-Up Pilots to Evaluate “Fix Chaired: T. Inoue for Life”, a Low-Hazardous Embalming Method Preserving Life-Like Morphology. A.J. Van Dam. Leiden Univ. Med. Cell Biology Ctr., Netherlands. Developmental Biology/Morphology 3:30 14.2 Preparation of an Anatomical Donor Using the Sikon Soft-Cure Method. R.R. Sikon. Virginia State Anat. 3:00 12.1 In Vivo Analysis of Cilia Function and Donations Prog., Richmond. Connections to Renal Disease and Physiology. B.K. Yoder. 4:00 14.3 Evo-Devo Anatomy Dissected: An Approach Univ. of Alabama at Birmingham. Using Soft Embalming That Transforms the Regional-versus- 3:30 12.2 Primary Cilia of Inner Ear Hair Cells Do Not Systemic Debate. N.T. Boaz, R.L. Bernor, K. Meshida. Col. of Respond to Mechanical Stimuli. A.A. Indzhykulian, M. Delling, Henricopolis Sch. of Med., VA and Howard Univ. Col. of Med. X. Liu, Y. Li, T. Xie, D.P. Corey, D.E. Clapham. Harvard Med. Sch. and Boston Children’s Hosp. 15. SKIN DEEP: STRUCTURE AND FUNCTION 4:00 12.3 The Integration of Mechanobiology and Biomechanics at Primary Cilia. C.R. Jacobs, A. Nguyen. OF OSTEODERMS Columbia Univ. Symposium

13. FUTURE MEDICINE: THE IMPACT OF Sat. 3:00 pm—San Diego Convention Center, Room 7B 3D PRINTING Chaired: T. Owerkowicz

Symposium Evolution/Anthropology

Sat. 3:00 pm—San Diego Convention Center, Room 9 Developmental Biology/Morphology

Chaired: D. Mills 3:00 15.1 Fortified Frogs and Skeletogenesis in the Skin: Osteoderm Development and Structure across Tetrapods. Tissue Bioengineering M.K. Vickaryous, E.A.B. Gilbert, S.L. Delorme. Univ. of Stem Cells/ Regeneration Guelph, Canada. 3:30 15.2 Bone as a Buffer: Consequences for 3:00 13.1 3D Bioprinting Nanocomposite Scaffolds Design and Anaerobic Physiological Performance. D. Warren. for Complex Tissue Regeneration. G. Zhang. George Saint Louis Univ. Washington Univ. 4:00 15.3 Heat Transfer through Skin with and without 3:30 13.2 Novel Method for the 3D Printing of Bioactive Osteoderms in the American Alligator. T. Owerkowicz. Biomedical Devices. J.A. Weisman, U. Murthy, K. Tappa, D.K. California State Univ., San Bernardino. Mills. LSU Hlth. Sci. Cr., Shreveport and Louisiana Tech Univ. 4:00 13.3 3D Printing of Customized Implants for 16. WELCOME AND KEYNOTE SPEAKER Treatment of Orofacial Deformities and Defects. L. Tayebi. Marquette Univ. Sch. of Dent. Keynote Lecture

Sat. 4:45 pm—San Diego Convention Center, Room 8 Regenerative Medicine (Stem Cells, Tissue Regeneration, Biomaterials) Are You Tweeting about Welcome and introduction by AAA President, Kimberly Topp 4:45 Chair’s Introduction. EB 2016? 4:50 New Insights into Stem Cells in Mammary Development and Breast . Z. Werb. UCSF. To Tweet use #expbio

Be sure to follow EB on Facebook and Twitter.

4 SATURDAY BIOCHEMISTRY Biochemistry and Molecular Biology

17. ASBMB PROFESSIONAL DEVELOPMENT 21. ASBMB 20TH ANNUAL UNDERGRADUATE PROGRAM FOR GRADUATE STUDENTS AND STUDENT RESEARCH POSTER COMPETITION POSTDOCTORAL TRAINEES Special Event S Special Session Sat. 1:00 pm—San Diego Convention Center, Room 6B A Sat. 8:30 am—San Diego Convention Center, Room 6A Cochaired: K. Cornely, K. Fox and P. Ortiz T Cochaired: C. Heinen and T. O’Connell Pre-registration required. Check-in and set-up begin Invitation only. Required participation by all Graduate/ at Noon. Postdoctoral and Underrepresented Graduate Student Travel Award recipients. 22. ASBMB PROFESSIONAL DEVELOPMENT Follow the conversation: #education PROGRAM WORKSHOPS FOR GRADUATE STUDENTS AND POSTDOCTORAL TRAINEES 18. BUILDING YOUR OUTREACH PROGRAM FROM Workshop A TO Z Sat. 2:30 pm—Locations (multiple) Workshop Pathways to Your Own Lab Sat. 9:00 am—San Diego Marriott Marquis & Marina Hotel, San Diego Convention Center, Room 1A San Diego Ballroom C Implementing Your IDP Advance event registration required. San Diego Convention Center, Room 1B Learn how to start, expand or improve your own public Taking the Industrial Route engagement program. San Diego Convention Center, Room 6D Follow the conversation: #scicomm Follow the conversation: #education

19. ASBMB UNDERGRADUATE STUDENT ANNUAL 23. ASBMB EXPLORING CAREERS SPEED- MEETING ORIENTATION NETWORKING EVENT

Special Session Workshop

Sat. 11:30 am—San Diego Convention Center, Room 6B Sat. 4:30 pm—San Diego Convention Center, Room 6A Orientation open to all undergraduates attending the poster Undergraduates learn about a variety of exciting career competition. No registration required. options in this fun and fast-paced workshop.

20. COMMUNICATION WORKSHOP: MAKE YOUR 24. ASBMB BUSINESS MEETING ELEVATOR PITCH Business Meeting Workshop Sat. 6:00 pm—San Diego Convention Center, Sat. 12:30 pm—San Diego Marriott Marquis & Marina Ballroom 20BC Hotel, San Diego Ballroom C

5 BIOCHEMISTRY/NUTRITION SATURDAY

25. ASBMB OPENING LECTURE: HERBERT TABOR 26. ASBMB OPENING RECEPTION RESEARCH AWARD LECTURE Special Event Award Lecture Sat. 7:30 pm—San Diego Convention Center, Sails Pavilion Sat. 6:00 pm—San Diego Convention Center, Immediately follows the ASBMB Opening Lecture. ASBMB Ballroom 20BC members and biochemistry attendees welcome. Science Follow the conversation: #bigtalks Outreach and ASBMB Student Chapter Activity Posters will be presented during the reception for attendees to explore and 6:00 Awardee introduction. become inspired. 6:45 25.1 Eukaryotic Transcription Mechanisms: From Nuclear RNA Polymerases to General Initiation Factors, - Specific Activators, Coactivators and Chromatin. R.G. Roeder. 27. ASBMB SCIENCE OUTREACH AND STUDENT The Rockefeller Univ. CHAPTERS ACTIVITY POSTERS

Poster Discussion

Sat. 7:30 pm—San Diego Convention Center, Sails Pavilion Science Outreach and ASBMB Student Chapter Activity Posters will be featured during the ASBMB Opening Reception. All posters presented at 7:30 PM. Follow the conversation: #scicomm

Nutrition

28. NUTRITIONAL SCIENCES COUNCIL BUSINESS 10:30 Case Study II: USDA FoodAPS: Examining Food MEETING AND BREAKFAST Assistance Programs. M. Denbaly. USDA Econ. Res. Svc. Business Meeting 11:00 How to Apply Big Data and Analytics to Food Intake Measures at Population and Individual Levels. S. Sat. 7:00 am—San Diego Convention Center, Room 28D/E Intille. Northeastern Univ. 11:30 Panel Discussion. 29. BIG DATA AND INNOVATIVE APPROACHES TO UNDERSTANDING DIETARY PATTERNS 30. CLINICAL EMERGING LEADER AWARD AND HEALTH ORAL COMPETITION

Symposium Award Competition (Sponsored by: International Life Sciences Institute, Sat. 9:00 am—San Diego Convention Center, Room 33BC North America) Chaired: C.W. Bales

Sat. 8:30 am—San Diego Convention Center, Ballroom 20D 9:00 Introduction. Chaired: B.O. Schneeman 9:15 Effects of Polyphenolic-Rich Dark Chocolate and Almonds on Cardiovascular Risk Factors in Cochaired: B.D. Flickinger Overweight and Obese Adults. Y. Lee, C. Berryman, S. West, C-Y.O. Chen, J. Blumberg, A. Preston, K. Nutritional Epidemiology Lapsley, J. Fleming, P. Kris-Etherton. Penn State, 8:30 Welcome and Introduction by Session Chairs. USDA at Tufts Univ., Hershey Co., PA and Almond Bd. B. Scheeman, B. Flickinger. USAID, Archer of California, Modesto. (293.1) Daniels Midland. 9:30 Higher Protein Intake Improves Sleep and Blood 8:40 Dietary Patterns and Health Outcomes: A Review. R. Pressure, and Influences the Relation between Bailey. Purdue Univ. Changes in Blood Pressure and Sleep during Energy 9:10 Vision for the Future: Big Data and Innovative Restriction in Middle-Aged Overweight and Obese Approaches to Studying Dietary Patterns and Health/ Adults. J. Zhou, J.E. Kim, W.W. Campbell. Purdue Disease. B. Lee. Johns Hopkins Bloomberg Sch. of Univ. (415.6) Publ. Hlth. 10:00 Impact of Body Mass Index and Metabolic Health Status 9:40 Case Study I: Applying Big Data Approaches to Study on All-Cause Mortality Risk among Older Adults. F.W. Food and Diet Patterns on Health Markers. J. Cheng, X. Gao, D.C. Mitchell, C. Wood, C. Still, G.L. Ordovás. USDA at Tufts Univ. Jensen. Penn State and Geisinger Obesity Inst., 10:10 Break. Danville, PA. (417.1)

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10:15 Effects of Dietary Protein and Fiber at Breakfast on 32. OBESITY, IRON METABOLISM DYSFUNCTION Postprandial Appetite, Neural Responses to Visual AND CHRONIC DISEASE Food Stimuli, and Ad Libitum Energy Intake at Lunch in Overweight Adults. R.D. Sayer, A. Amankwaah, Symposium G. Tamer; Jr, N. Chen, A. Wright, J. Tregellas, M. Cornier, D. Kareken, T. Talavage, M. McCrory, W. Sat. 10:30 am—San Diego Convention Center, Room Campbell. Weldon Sch. of Biomed. Engin., Purdue 31ABC S Univ., Univ. of Colorado Sch. of Med., Anschutz Med. Chaired: L. Tussing-Humphreys Campus, Indiana Univ. Sch. of Med. and Georgia A State Univ. (418.7) Cochaired: N. Gletsu-Miller T 10:30 Impact of Maternal Infection and Breast Inflammation Cellular and Molecular Nutrition on Infant Growth in Guatemala. H.M. Wren, A.L. Leblanc, C. Li, N.W. Solomons, M.E. Scott, K.G. 10:30 Systemic Iron Regulation in Health and Disease. E. Koski. McGill Univ., St-Anne-de-Bellevue, Montreal Nemeth. UCLA. and CeSSIAM, Guatemala City. (45.6) 10:55 Novel Targets in Obesity and Diabetes: The Role of Iron and Hypoxia in the Regulation of Appetite and 31. POSTDOCTORAL RESEARCH AWARD Metabolism. D. McClain. Wake Forest Univ. Sch. ORAL COMPETITION of Med. 11:20 Macrophage Iron Handling in Health and Disease. A. Award Competition Hasty. Vanderbilt Univ. Sch. of Med. 11:45 Brain Iron Accumulation, Insulin Resistance and Sat. 9:30 am—San Diego Convention Center, Room 32AB Cognition in Obese Adults. J-M. Fernandez-Real. 9:30 Introduction. Hosp. of Girona “Dr. Josep Trueta” 9:40 HIV-Infected Pregnant and Lactating Women Have Higher Serum Levels Than HIV-Uninfected 33. GLOBAL NUTRITION: OVERWEIGHT, OBESITY Women and Aflatoxin Levels Are Higher during Early AND NUTRITION TRANSITION Postpartum Than during Pregnancy among HIV- Infected Women. B.K. Natamba, J-S. Wang, S.L. Minisymposium Young, S. Ghosh, J.K. Griffiths. Harvard Univ., Gulu (Sponsored by: Global Nutrition Council) Univ., Uganda, Univ. of Georgia, Cornell Univ. and Tufts Univ. (668.5) Sat. 10:30 am—San Diego Convention Center, Room 30B 10:00 Formula Milk Alters Microbial Diversity in Porcine Colon and Impacts Immune Response. M.K. Saraf, A.K. Chaired: TBD

Bowlin, S.V. Chintapalli, K. Shankar, T. LeRoith, Cochaired: M. Garcia Meza M.J. Ronis, T.M. Badger, L. Yeruva. Arkansas Children’s Nutr. Ctr., Univ. of Arkansas for Med. Sci., 10:30 33.1 Recommended Anthropometric Cut-Offs for VA-MD Col. of Vet. Med. and LSU Hlth. Sci. Ctr., New Population Screening of Diabetes and Pre-diabetes Need Orleans. (406.8) to Be Evaluated in Resource-Limited Settings. E.A. Yu, J.L. 10:20 Hepcidin Attenuates Zinc Efflux in Caco-2 Cells. S.R. Finkelstein, W. Bonam, M.J. Glesby, P.M. Brannon, S. Mehta. Hennigar, J.P. McClung. U.S. Army Res. Inst. of Cornell Univ., Arogyavaram Med. Ctr., Andhra Pradesh, India Envrn. Med., Natick, MA. (292.3) and Weill Cornell Med. Col. 10:40 A Plasma Proteome Is Associated with Anthropometric 10:45 33.2 Early Childhood Predictors of Lifecourse BMI Status in School-Aged Children in Nepal. S.E. Lee, Latent Class Trajectories in a Guatemalan Cohort. N.D. Ford, P. Christian, K. Schulze, R.N. Cole, L.S.F. Wu, M. Ramirez-Zea, R. Martorell, A.D. Stein. Emory Univ. and Inst. J.D. Yager, J. Groopman, C.P. Stewart, K.P. West; of Nutr. of Central America and Panama (INCAP), Guatemala. Jr. Johns Hopkins Bloomberg Sch. of Publ. Hlth., 11:00 33.3 Stunting and Its Relationship to Obesity in the Johns Hopkins Sch. of Med. and Univ. of California, U.S. Affiliated Pacific: A Study of the Children’s Healthy Living Davis. (432.2) Program. R. Novotny, F. Li, R. Leon Guerrero, P. Coleman, 11:00 Trimethylamine-N-Oxide Biomarker Response Is T. Fleming, A. Bersamin, J. Deenik, L.R. Wilkens. Univ. of a Function of Dietary Precursor Intake and Gut Hawaii, Mangilao, Guam, Saipan, No. Mariana Islands, Pago Microbiota Composition in Healthy Young Men. C.E. Pago, American Samoa and Fairbanks, AK. Cho, S. Taesuwan, O.V. Malysheva, E. Bender, N.F. 11:15 33.4 Height, Weight and Body Mass Index in Low- Tulchinsky, J. Yan, J.L. Sutter, M.A. Caudill. Cornell and Middle-High-Income Urban Preschoolers in the Western Univ. (406.6) Highlands of Guatemala. M.R. García-Meza, C.M. Doak, 11:20 Trace Element Distribution in Flatiron Mice, a Genetic J.J.S. Beintema, M.N. Orozco, R. Gwaltney, H.B. Rolker, Model of Human Ferroportin Disease. Y.A. Seo, N.W. Solomons. CeSSIAM Quetzaltenango, Guatemala, VU M. Wessling-Resnick. Harvard Sch. of Publ. Amsterdam and CeSSIAM, Guatemala City. Hlth. (292.7) 11:30 33.5 Parenting Behaviors and Weight Status of 11:40 Conclusion. Junior High School Students in China. Z. Tian, M. Wen, W. Wang, H. Xue, J. Min, Y. Wang. Univ. at Buffalo, SUNY, Univ. of Utah and Renmin Univ of China, Beijing.

7 NUTRITION SATURDAY

11:45 33.6 Protein Intake, Breastfeeding Frequency 12:15 34.8 13C Natural Abundance of Serum Retinol Is a and Breastfeeding Duration Affect BMI from Infancy to Mid Novel Biomarker for Evaluating Effectiveness of Provitamin A Childhood. M. Wright, D. Sotres-Alvarez, M. Mendez, L. Biofortified Maize and Carrots in Male Mongolian Gerbils. B.M. Adair. Univ. of North Carolina at Chapel Hill. Gannon, I. Pungarcher, L. Mourao, C.R. Davis, P.M. Simon, 12:00 33.7 Development and Evaluation of a Food Behavior K.V. Pixley, S.A. Tanumihardjo. Univ. of Wisconsin-Madison Survey to Assess Nutrition Transition among Adolescents in and Intl. Maize and Wheat Improvement Ctr., El Batan, Mexico. South India. N. Shaikh, S. Patil, U. Ramakrishnan, K. Yount, S. Cunningham. Emory Univ. and BLDE Univ., India. 35. ASN YOUNG MINORITY INVESTIGATOR 12:15 33.8 Low Plasma Concentrations of High-Density ORAL COMPETITION Lipoprotein Cholesterol Associated with Shorter Duration of Pregnancy: A Nested Cohort Study in Ghana. B.M. Oaks, Award Competition C.P. Stewart, K.D. Laugero, S. Adu-Afarwuah, A. Lartey, S.A. Vosti, P. Ashorn, K.G. Dewey. Univ. of California, Davis, (Organized by: the ASN Minority and Diversity USDA, Davis, Univ. of Ghana and Univ. of Tampere Sch. of Affairs Committee) Med., Finland. Sat. 11:30 am—San Diego Convention Center, Room 33BC 34. CARIG: CAROTENOID AND RETINOID: Chaired: M.D. Teran-Garcia MOLECULAR MECHANISMS OF ACTION 11:30 Overview and Introduction. M.D. Teran-Garcia. 11:45 DHA Status is Related to Prefrontal Cortex-Mediated Minisymposium Impulse Control in Adolescents. V. Darcey. (Sponsored by: CARIG RIS) Georgetown Univ. (407.3) 12:00 Association of Vitamin D Status with Dual Task Physical Sat. 10:30 am—San Diego Convention Center, Room 30C Performance in Older Adults. J. Lopez. Florida Intl. Univ. (917.14) Chaired: E. Johnson 12:15 Maternal Plasma Folate, Vitamin B12 Levels and Cochaired: L. Jahns Multivitamin Supplementation during Pregnancy and Risk of Autism Spectrum Disorder in the Boston Birth 10:30 34.1 Dietary Tomato Powder Inhibits Hepatic Cohort. R. Raghavan. Johns Hopkins Bloomberg Steatosis, Inflammation and Tumorigenesis in Beta- Sch. of Publ. Hlth. (151.6) Carotene-15, 15’-Oxygenase (BCO1) and Beta-Carotene-9, 12:30 Molds Attack Rice, but We Don’t Know What to Do. A 10’-Oxygenase (BCO2) Double Knockout Mice. C-C. Li, C. Liu, Qualitative Study of Farming Families’ Perceptions K. Hu, D.E. Smith, J. von Lintig, X-D. Wang. USDA at Tufts of Food Safety in Banke, Nepal. J.A. Chavez. Tufts Univ.and Sch. of Med., Case Western Reserve Univ. Univ. (891.10) 10:45 34.2 Lutein, but Not Other Carotenoids, Selectively 12:45 Mango Supplementation Prevents Gut Microbial Inhibits Breast Cancer Cell Growth through Several Molecular Dysbiosis and Modulates Short Chain Fatty Acid Mechanisms. H.M. Swanson, J.R. Smith; Jr., X. Gong, L.P. Production Independent of Body Weight Reduction in Rubin. Paul L. Foster Sch. of Med., Texas Tech Univ. Hlth. Sci. C57BL/6 Mice Fed a High Fat Diet. B. Ojo. (1166.6) Ctr. and Univ. of Texaas El Paso. 11:00 34.3 Astaxanthin Attenuated the Expression of 36. ASN SPONSORED SATELLITE PROGRAM: Fibrogenic Induced by High Glucose Alone and in Combination with Transforming Growth Factor 1β in Hepatic PULSES FOR HEALTHY PEOPLE AND A Stellate Cells. M. Bae, J-Y. Lee. Univ. of Connecticut. HEALTHY PLANET: EMERGING RESEARCH 11:15 34.4 All-trans-Retinoic Acid Inhibits Adipogenesis AND OPPORTUNITIES by Interrupting Gadd45α-Induced Zfp423. B. Wang, M. Zhu, M. Du. Washington State Univ. ASN Satellite 11:30 34.5 Vitamin A Supplementation Only Transiently (Organized and Sponsored by: the US Dry Pea and Lentil Increases Retinol Concentrations in Extrahepatic Organs of Council, Pulse Canada, World Food Center at University Neonatal Rats Raised under Vitamin A-Marginal Conditions. of California, Davis J.K. Urbanek, L. Tan, M.H. Green, A.C. Ross. Penn State and Univ. of Alabama. and the American Pulse Association) 11:45 34.6 SNPs in Lipid and Carotenoid Metabolism and Sat. 12:45 pm—San Diego Convention Center, Room 33BC Absorption Genes Impact Carotenoid Responses to a Tomato- Soy Juice Intervention. N.E. Moran, J.M. Thomas-Ahner, For more information on ASN Sponsored Satellite J.L. Fleming, J.P. McElroy, E.M. Grainger, K.M. Riedl, S.J. Programs, please visit http://scientificsessions.nutrition.org Schwartz, S.K. Clinton. The Ohio State Univ. /satellitesessions/. 12:00 34.7 Metabolomic Profile of Serum Retinol Concentrations in the ATBC Study Cohort. D. Albanes, O. Panagiotou, S. Weinstein, S. Moore, A. Mondul. NCI, NIH and Univ. of Michigan Sch. of Publ. Hlth.

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38. PHENHRIG ANNUAL SYMPOSIUM: 2:15 Effect of Vitamin D Fortified Cheese on Oral Glucose FLAVONOIDS/POLYPHENOLS AND Tolerance in Individuals Exhibiting Marginal Vitamin EPIGENETICS: IS THERE A CONNECTION? D Status and an Increased Risk for Developing Type 2 Diabetes: A Double-Blind, Randomized Placebo- Symposium Controlled Clinical Trial. T.S. Moreira-Lucas, A.M. Duncan, R. Rabasa-Lhoret, R. Vieth, A. Gibbs, A. (Sponsored by: Phenolic and Human Health Badawi, T.M.S. Wolever. Univ. of Toronto, Univ. of Research Interest Group (PhenHRIG)) Guelph, Canada, Clin. Res. Inst. of Montreal and S Publ. Hlth. Agcy. of Canada, Toronto. (917.1) A Sat. 1:00 pm—San Diego Convention Center, Room 29AB 2:30 Ablation of BCO2 Leads to Increased Susceptibility to T PHENHRIG information, including speakers, is available High Fat Diet-Induced Metabolic Disorders in Mice. L. at http://phenhrig.org Wu, X. Guo, A. Davis, T.P. Soh, S. Clarke, E. Lucas, B. Smith, W. Wang, D. Medeiros, D. Lin. Oklahoma State Univ., Kansas State Univ. and Univ. of Missouri- 39. GRADUATE STUDENT RESEARCH AWARD Kansas City. (271.5) ORAL COMPETITION 2:45 Recommended Anthropometric Cut-Offs for Population Screening of Diabetes and Pre-diabetes Need to Be Award Competition Evaluated in Resource-Limited Settings. E.A. Yu, J.L. (Sponsored by: Nutritional Sciences Council) Finkelstein, W. Bonam, M.J. Glesby, P.M. Brannon, S. Mehta. Cornell Univ., Arogyavaram Med. Ctr., Andhra Sat. 1:00 pm—San Diego Convention Center, Room 29CD Pradesh, India and Weill Cornell Med. Col. (33.1) 3:00 Zinc and ZIP14 (Slc39a14) Are Required for Adaptation Chaired: C. Davis - GSRA to ER Stress in Mouse Liver. M-H. Kim, T.B. Aydemir, 1:00 Native African Plant Materials Modify In Vitro R.J. Cousins. Univ. of Florida. (148.2) Bioaccessibility of Provitamin A Carotenoids from 3:15 Household Food Insecurity Access Scale and Household Blended Cereal Products. H. Debelo, C. Ndiaye, M. Food Insecurity Access Prevalence as Predictor Ferruzzi, B. Hamaker. Purdue Univ. (914.4) of Stunted Child and Overweight/Obese Mother in 1:15 Adipocyte-Specific Ablation of Long-Chain Acyl-CoA Urban Indonesia. T. Mahmudiono, D.R. Andrias, T.S. Synthetase-4 in Mice Protects against Diet-Induced Nindya, H. Megatsari, R. Rosenkranz. Kansas State Obesity-Associated Decreases in White Adipocyte Univ. and Univ. Airlangga, Indonesia. (273.8) Oxygen Consumption and Whole Body Energy 3:30 Serum Bone-Building Metabolites Are Enhanced by a Expenditure. E.A. Killion, D. Kong, A.S. Greenberg. Restricted Vitamin A Intervention in Zambian Children USDA at Tufts Univ. and Tufts Univ. Sackler Sch. of with High Liver Reserves of Vitamin A. K.E. Olsen, N. Grad. Biomed. Sci. (267.8) Binkley, B.M. Gannon, S.A. Tanumihardjo. Univ. of 1:30 Using a Humanoid Robot along with a Registered Wisconsin-Madison. (678.24) Dietitian in an After-School Program to Promote 3:45 Depletion of Dietary MicroRNAs from Cow’s Milk Causes Healthy Eating Habits and Physical Activity in School- an Increase of Purine Metabolites in Human Body Aged Children. N. Mikati, M. Eltoukhy, F. Huffman. Fluids and Mouse Livers. A.G. Aguilar Lozano, S. Florida Intl. Univ. and Univ. of Miami. (276.8) Baier, J. Adamec, M. Sadri, D. Giraud, J. Zempleni. 1:45 DHA Is More Potent Than EPA in Attenuating Univ. of Nebraska-Lincoln. (127.1) Cardiometabolic Risk in Men and Women: A Randomized Double-Blind, Placebo-Controlled 40. SEX AND METABOLISM: LATE BREAKING Crossover Trial. J. Allaire, P. Couture, A. Charest, RESEARCH ON THE ROLE OF ESTROGEN M. Leclerc, J. Marin, M-C. Lépine, A. Tchernof, B. RECEPTORS IN CARDIOMETABOLIC HEALTH Lamarche. Univ. Laval and Univ. Inst. of Cardiol. and Pneumol. of Québec. (130.1) Symposium 2:00 MicroRNAs as a Novel Mechanism by Which Eicosapentaenoic Acid Mediates Inflammation in (Sponsored by: Energy and Macronutrient Diet-Induced Obesity. E. Yen, N. Wijayatunga, M. Metabolism RIS) Pahlavani, L. Ramalingam, K.R. Kottapalli, N.S. Sat. 3:00 pm—San Diego Convention Center, Ballroom 20D Kalupahana, P. Gunaratne, K. Rajapakshe, C. Coarfa, S. Dharmawardhane, N. Moustaid-Moussa. Chaired: V.J. Vieira-Potter Texas Tech Univ., Univ. of Sri Jayewardenepura and Univ. of Peradeniya, Sri Lanka, Univ. of Houston, Cellular and Molecular Nutrition Baylor Col. of Med. and Univ. of Puerto Rico-Med. 3:00 Estrogen, Metabolism and Energy Homeostasis - Sci. Campus. (911.7) Brain-related mechanisms. D. Clegg. Cedars-Sinai Diabetes and Obesity Res. Inst. 3:25 Estrogen Signaling and Insulin-mediated Glucose Uptake after Menopause: “Timing Hypothesis” Revisited. R. Van Pelt. Univ. of Colorado Anschutz Med. Campus. 3:50 Estrogen Signaling and Vascular Endothelial Function with the Menopause Transition. K. Moreau. Univ. of Colorado Anschutz Med. Campus.

9 NUTRITION SATURDAY

4:15 Effects of Estrogen Receptor Alpha Signaling on 4:30 42.7 Effect of Short-Chain Fatty Acid Acetate Immunometabolism. A. Hevener. UCLA. on Colon Cancer. M. Sahuri Arisoylu, J.D. Bell. Univ. of Westminster, U.K. 41. DIETARY FIBER’S ESSENTIALITY FOR THE 4:45 42.8 Inactivation of Pyruvate Dehydrogenase INTESTINE AND THE MICROBIOTA Complex Mediates the Selective Effects of Butyrate on Colorectal Cancer Cells. A. Han, N. Bennett, A. MacDonald, Symposium M. Johnstone, J. Whelan, D.R. Donohoe. Univ. of Tennessee, Knoxville. Sat. 3:00 pm—San Diego Convention Center, Room 31ABC

Chaired: D.T. Gordon 43. NUTRITIONAL EPIDEMIOLOGY: INNOVATION AND VALIDATION OF DIETARY ASSESSMENT Cochaired: D.M. Klurfeld TOOLS AND THEIR APPLICATIONS Clinical and Translational Nutrition Minisymposium 3:00 Mucosal Atrophy and other Intestinal Dysfunctions with Total Parenteral Nutrition and Limited Enteral (Sponsored by: Nutritional Epidemiology RIS) Nutrition. TBD. Sat. 3:00 pm—San Diego Convention Center, Room 30A 3:25 Dietary Fiber, Gut Microbiota and Immune Response. C. MacKay. Charles Perkins Ctr.-Sydney Med. Sch. Chaired: C.J. Boushey 3:50 Contributions of Gut Microbiota to Health Benefits of Cochaired: S. Sahni Dietary Fiber. V. Mai. Univ. of Florida. 3:00 43.1 Method of Assessing Daily Intake-Frequencies 42. DIET AND CANCER: POPULATIONAL AND for Major Food Groups Using Dietary Screener Data. E. MOLECULAR STUDIES OF BREAST AND Calloway, T. Smith, C. Pinard, A. Oh, L. Nebeling, E. COLON CANCER Hennessy, A. Yaroch. Gretchen Swanson Ctr. for Nutr., Omaha and NCI, NIH. Minisymposium 3:15 43.2 The ASA24-Kids-2014 versus Traditional 24- Hour Diet Recall for Assessing Dietary Intake of Adolescents. (Sponsored by: Diet and Cancer RIS) S. Summer, A. Hughes, L. Benken, N. Ollberding, H.J. Kalkwarf. Cincinnati Children’s Hosp. Med. Ctr. Sat. 3:00 pm—San Diego Convention Center, Room 33A 3:30 43.3 A Validation of Automated Self-Administered Chaired: E. Park 24-Hour Dietary Recalls Relative to Interviewer-Administered Recalls Using the Nutrition Data System for Research. D.C. Cochaired: K. Ferrini Mitchell, F.W. Cheng, C.D. Still, G.L. Jensen. Penn State and 3:00 42.1 Consumption of Total and Individual Sugars, Geisinger Hlth. Syst., Danville, PA. Sugary Foods and Sugary Beverages in Relation to Adiposity- 3:45 43.4 Use of Skin Carotenoids as a Biomarker for Related Cancer Risk in the Framingham Offspring Cohort Fruit and Vegetable Intake among Mexican-Origin Children in a (1991-2013). N. Makarem, Y. Lin, E.V. Bandera, P. Jacques, Community Setting. A.L. Aguilera, A. de la Torre, L.L. Kaiser. N. Parekh. NYU, Rutgers Univ. and USDA at Tufts Univ. Univ. of California, Davis. 3:15 42.2 Four a priori-Defined Diet Quality Indexes and 4:00 43.5 The Breath Carbon Isotope Ratio Is a Survival among Men and Women with Colorectal Cancer: The Promising Biomarker of Added Sugar Intake. D.M. O’Brien, Multiethnic Cohort. G. Maskarinec, S. Jacobs, B.E. Harmon, J.A. Black, K. Niles, D. Schoeller. Univ. of Alaska Fairbanks L.R. Wilkens, L. Le Marchand, L.N. Kolonel, C.J. Boushey. and Univ. of Wisconsin-Madison. Univ. of Hawaii and Univ. of Memphis Sch. of Publ. Hlth. 4:15 43.6 Development and Validation of Empirical 3:30 42.3 Dietary Phytosterols Intakes Are Inversely Indices of Dietary Insulinemic Potential. F.K. Tabung, W. Wang, Associated with Colorectal Cancer Risk among Chinese T.T. Fung, F.B. Hu, S. Smith-Warner, J.E. Chavarro, W.C. Population. C-X. Zhang, J. Huang, M. Xu, W-P. Luo, Y-J. Fang. Willett, E.L. Giovannucci. Harvard T.H. Chan. Sch. of Publ. Sch. of Publ. Hlth. and Cancer Ctr., Sun Yat-sen Univ., China. Hlth., Simons Col. and Harvard Med. Sch. 3:45 42.4 Dietary Carotenoid, Retinol, and Ascorbic 4:30 43.7 Development and Validation of a Nutrition Acid Intake and Its Association with Breast Density in Young Transition Diet Score for Adolescents in India. N. Shaikh, U. Women. J.N. Bodor, S. Jung, C. Klifa, L. Van Horn, J.F. Ramakrishnan, S. Patil, K. Yount, R. Martorell, K.M. Venkat Dorgan. Univ. of Maryland Med. Ctr., Univ. of Maryland Sch. Narayan, S. Cunningham. Emory Univ. and BLDE Univ., India. of Med., Dangeard Group, Luynes, France and Northwestern 4:45 43.8 Evaluation of Dietary Assessment Tools: Does Univ. Feinberg Sch. of Med. ‘Validated’ Mean What We Think It Means? S.I. Kirkpatrick, A.F. Subar, S.M. Krebs-Smith, F.E. Thompson, J. Reedy, T.E. 4:00 42.5 Effect of 1,25(OH)2D in Regulating Glutamic- Oxaloacetic Transaminase 1 and Redox Balance during Breast Schap, L. Vanderlee, P. Robson, I. Csizmadi, B.A. Boucher, Cancer Progression. X. Zhou, T. Wilmanski, D. Teegarden. I. Massarelli, I. Rondeau. Univ. of Waterloo, Canada, NCI, Purdue Univ. NIH, USDA, Alexandria, VA, Alberta Hlth. Svcs., Edmonton and 4:15 42.6 Reversal Effects of Genistein and Calgary, Cancer Care Ontario and Hlth. Canada, Ottawa. (-)-Epigallocatechin-3-Gallate on Repression of BRCA-1 Expression in Human Breast Cancer Cells with Activated AhR. O.I. Selmin, A.J. Papoutsis, D.F. Romagnolo. Univ. of Arizona.

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44. GLOBAL NUTRITION: NUTRITIONAL 45. MATERNAL, PERINATAL AND PEDIATRIC DEFICIENCY – PREVALENCE NUTRITION: MATERNAL FACTORS RELATED TO AND CONSEQUENCES PREGNANCY, LACTATION AND INFANT HEALTH

Minisymposium Minisymposium (Sponsored by: Global Nutrition Council) Maternal, Perinatal and Pediatric Nutrition RIS S Sat. 3:00 pm—San Diego Convention Center, Room 30B Sat. 3:00 pm—San Diego Convention Center, Room 30C A Chaired: P. Christian Chaired: C. Lovelady T

Cochaired: E. Widen 3:00 45.1 Calcium Absorption among Racially Diverse Pregnant Women. M.N.R. Lesser, L. Nguyen, J.C. King, K.O. 3:00 44.1 Is There an Increased Risk of Iodine Deficiency O’Brien, E.B. Fung. Children’s Hosp. Oakland Res. Inst., Univ. among Reproductive-Age Women (18-45) with “Normal” of California, Berkeley and Cornell Univ. Thyroid Function? P. Panth, N.M. DiMarco, L.J. Petterborg. 3:15 45.2 Trans-Generational Impact of Diet in Texas Woman’s Univ. Pregnancy: Maternal Dietary Intake of Grains during Pregnancy 3:15 44.2 The Sensitivity and Specificity of Thyroglobulin and Offspring Growth and Obesity from Birth through Age of as an Index of Iodine Status in Mildly Iodine Deficient Adults. 7 Years. Y. Zhu, S.F. Olsen, P. Mendola, F. Hu, C. Zhang. S.A. Skeaff, Z.F. Ma. Univ. of Otago, New Zealand. NICHD, NIH, Rockville, MD, Statens Serum Inst., Copenhagen 3:30 44.3 Vitamin B12 Status in Pregnant Women and Harvard Sch. of Publ. Hlth. and Their Infants in Southern India. J.L. Finkelstein, P. 3:30 45.3 Different Duration of Diet Transitions from Dwarkanath, S. Mehta, T. Thomas, A.V. Kurpad. Cornell Univ. a High-Fat Diet to a Normal-Fat Diet before Pregnancy and St. John’s Res. Inst., Bangalore. Deferentially Affect the of Offspring Obesity with 3:45 44.4 Association of Early Nutrition Deficit with Early a Sex-Dependent Manner. Q. Fu, Y. Zhou, H. Xu, P. Olson, Childhood Development in Children 36 to 59 Months within L. Xie. Univ. of North Dakota, Tongji Hosp and Hubei Cancer and across Populations in Low- and Middle-Income Countries. Hosp., Wuhan, China and Texas A&M Univ. L.I. Reyes, E.A. Frongillo, S. Kulkarni, S. Basnet, F. de 3:45 45.4 Association between Breastfeeding, Maternal Castro. Univ. of South Carolina and Mexico Natl. Inst. of Publ. Weight Loss and Body Composition at 3 Months Postpartum. Hlth., Cuernavaca. S.A. Elliott, L.C.R. Pereira, E. Guigard, L.J. McCargar, C.C.M. 4:00 44.5 Determinants of Developmental Milestones Prado, R.C. Bell. Univ. of Alberta. in Infants and Young Children in Bihar, India. L. Larson, R. 4:00 45.5 Maternal Obesity, 25(OH)D Concentration Mehta, P. Kekre, P. Verma, M. Young, A. Webb Girard, U. and Bone Mineral Density in Breastfeeding Dyads. S. Sen, Ramakrishnan, I. Chaudhuri, S. Srikantiah, R. Martorell. A. Penfield-Cyr, Z. Lu, M. Ebeling, B. Hollis, C. Howard, C. Emory Univ. and CARE India, Patna. Wagner. Brigham and Women’s Hosp., Med. Univ. of South 4:15 44.6 Maternal Vitamin D Status and Adverse Carolina and Rochester Gen. Hosp. Pregnancy and Neonatal Outcomes in India. J.L. Finkelstein, 4:15 45.6 Impact of Maternal Infection and Breast C. Duggan, S. Mehta, T. Thomas, K. Srinivasan, A.V. Kurpad. Inflammation on Infant Growth in Guatemala. H.M. Wren, Cornell Univ., St. John’s Res. Inst., Bangalore, Harvard T.H. A.L. Leblanc, C. Li, N.W. Solomons, M.E. Scott, K.G. Koski. Chan Sch. of Publ. Hlth. and Children’s Hosp. Boston. McGill Univ., St-Anne-de-Bellevue, Montreal and CeSSIAM, 4:30 44.7 Path Analyses of 18-Month Language, Motor, Guatemala City. and Executive Function Scores in Malawi. E.L. Prado, P. 4:30 45.7 Perceived Breastmilk Insufficiency and HIV Ashorn, U. Ashorn, K. Maleta, J. Sadalaki, C. Stewart, R. Are Associated with Exclusive Breastfeeding at 1 and 3 Months Stewart, S. Vosti, K. Dewey. Univ. of California, Davis, Univ. among Mothers in Northern Uganda. S.L. Martin, S.M. Collins, of Tampere Sch. of Med., Finland, Univ. of Malawi Col. of Med. E.M. Widen, D. Achidri, S.L. Young. Cornell Univ., Columbia and Univ. of Manchester, U.K. Univ. and PRENAPS Uganda, Gulu. 4:45 44.8 Newly Diagnosed HIV Is Associated with Lower 4:45 45.8 The Effect of the Baby Friendly Hospital Initiative Rates of Gestational Weight Gain and Loss of Mid-Upper Arm on Exclusive Breastfeeding Rates in Hospitals. J.A. Patterson, Circumference among Pregnant Kenyan Women. E.M. Widen, B.H. Olson, N.S. Keuler. Univ. of Wisconsin-Madison. S. Collins, P. Wekesa, N. Krumdieck, M. Onono, S.L. Young. Columbia Univ. Med. Ctr., Cornell Univ., Kenya Med. Res. Inst. and Weill Cornell Med.

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11 NUTRITION SATURDAY

46. TRANSLATIONAL RESEARCH 5:00 Effects of Polyphenolic-Rich Dark Chocolate and AWARD COMPETITION Almonds on Cardiovascular Risk Factors in Overweight and Obese Adults. Y. Lee, C. Berryman, Award Competition S. West, C-Y.O. Chen, J. Blumberg, A. Preston, K. Lapsley, J. Fleming, P. Kris-Etherton. Penn State, (Sponsored by: Nutrition Translation RIS Beachbody and USDA at Tufts Univ., Hershey Co., PA and Almond Bd. Tate and Lyle) of California, Modesto. (293.1) Sat. 3:15 pm—San Diego Convention Center, Room 32AB 5:00 Effect of Vitamin D3 Supplementation on Telomerase Activity in Hispanics with Type 2 Diabetes. G.G. Zarini, Chaired: M. Braun M. McLean, J. Vaccaro, J. Exebio, S. Ajabshir, F.G. Huffman. Florida Intl. Univ. (1156.1) 3:15 Introduction. 5:00 Blood Cholesterol in Late-Life and Cognitive Decline: 3:30 Differences in the Infant Gut Microbiota Related to the A Longitudinal Study of the Chinese Elderly. C. Fatty Acid Composition of Human Milk: Results from Ma, Z. Yin, J. Luo, P. Zhu, X. Shi, X. Gao. Penn the GEHM Cohort. D.H. Taft, K.A. Dingess, C.J. State, Chinese Ctr. for Dis. Control and Prevent., Valentine, B.S. Davidson, N.J. Ollberding, D.V. Beijing. (407.4) Ward, J.T. Brenna, R.J. McMahon, A.L. Morrow. 5:00 Gray Matter Thickness of Inferior Frontal Cortex Mediates Cincinnati Children’s Hosp. and Med. Ctr., Mead the Relationship between Phosphatidylcholine and Johnson Nutr., Glenview, IL, Univ. of Massachusetts Executive Functions in Healthy, Older Adults. M.K. Med. Sch. and Cornell Univ. (406.7) Zamroziewicz, T. Das, S.L. Pereira, A.K. Barbey. 3:45 Assessing the Public’s Comprehension of Dietary Univ. of Illinois Urbana-Champaign and Abbott Nutr., Guidelines: Perception of Diet Quality Is Inversely Columbus, OH. (407.7) Associated with Dietary ED in U.S. Adults. J.A. 5:00 Dietary Protein and Functional Decline in Middle-Aged Vernarelli, R. Nouri. Fairfield Univ.(429.7) and Older Adults in the Framingham Offspring Study. 4:00 Novel Tool for Discrimination of Feeding Intolerance and J. Mustafa, M.R. Singer, M.L. Bradlee, R.C. Ellison, Necrotizing Enterocolitis Risk in the Preterm Infant. L.L. Moore. Boston Univ. Sch. of Med. (1156.3) J. Naberhuis, C. Wetzel, K. Tappenden. Baylor Col. 5:00 Hypoxia Compromised Barrier Integrity in IPEC-J2 of Med., USDA, Houston, Carle Fndn. Hosp., Urbana Monolayer Independent of Oxidative Stress. F. Liu, and Univ. of Illinois at Urbana-Champaign. (151.7) J.M. Lyte, N.K. Gabler, F.R. Dunshea. Univ. of 4:15 Does the Left Hand Know What the Right Hand Is Melbourne and Iowa State Univ. (1158.1) Doing? Part Ii: Alignment between the AFRI Childhood 5:00 The Modulatory Effect of Common Dietary Fatty Acids Obesity Prevention Challenge Area Program and the on IPEC-J2 Transport of and 2010 Dietary Guidelines. M.M. Koenings, C. Perez, Monolayer Barrier Integrity In Vitro. J.M. Lyte, N.K. K. Krishnan, D.N. Chester. IFSN, NIFA, Washington, Gabler, J.H. Hollis. Iowa State Univ. (1158.2) DC and Texas A&M Univ., Bryan. (433.2) 5:00 Black Berry Polyphenol Reduce Nox1 Function to 4:30 Menstrual Cycle Hormones, Food Intake, and Cravings. Inhibit Senescence in Vascular Smooth Muscle Cells. S. Krishnan, R. Tryon, L.C. Welch, W.F. Horn, N.L. J. Huang, R. Feresin, Y. Zhao, S. Pourafshar, B.H. Keim. Univ. of California, Davis and USDA, Davis. Arjmandi, G. Salazar. Florida State Univ. and Univ. of (418.6) Arkansas for Med. Sci. (420.2) 4:45 Network Social Support for Healthy and Obesogenic 5:00 Consuming < or 0.5 Servings of Red Meat per Day Behavior Influences Children’s Dietary Intake and > Does Not Have a Negative Impact on Cardiovascular Weight Change during Family-Based Behavioral Disease Risk Factors: A Systematic Review and Obesity Treatment. K.N. Balantekin, J.F. Hayes, R.P. Meta-analysis of Randomized Controlled Trials. L.E. Kolko, R.I. Stein, B.E. Saelens, R.R. Welch, M.G. O’Connor, J. Kim, W.W. Campbell. Purdue Univ. Perri, K.B. Schechtman, L.H. Epstein, D.E. Wilfley. (904.1) Washington Univ. Sch. of Med., Univ. of Pittsburgh, 5:00 Adherence to a Mediterranean Diet, and Effects on Seattle Children’s Hosp., Univ. of Florida and Univ. at Cardiometabolic Health in Older Australian:; Results Buffalo. (270.5) from the MedIterranean Diet for Cognition and Cardiovascular Health in the Elderly (MedLey) Trial. 47. ASN EMERGING LEADERS IN NUTRITION C.R. Davis, J. Bryan, C. Wilson, J. Hodgson, R. SCIENCE POSTER COMPETITION Woodman, K. Murphy. Univ. of South Australia, Sch. of Med., Flinders Univ. and Univ. of Western Australia. Poster Award Competition (293.5)

Sat. 6:00 pm—San Diego Convention Center, Sails Pavilion 5:00 From Visceral Fat to Brain Function: The Selectively Negative Influence of Central Adiposity on Finalists of the poster competition will be judged onsite. Neuroelectric Indices in Preadolescent Children. L. Announcement of the winners will be at the RIS and Council meetings. Raine, N. Cohen, A. Kramer, C. Hillman, N. Khan. Please see the onsite Emerging Leaders in Nutrition Science Poster Univ. of Illinois Urbana Champaign. (679.1) Competition Program Book for announcement details. 5:00 DHA Status Is Related to Prefrontal Cortex-Mediated Impulse Control in Adolescents. V.L. Darcey, S. El Poster judging will occur between 5:00 and 6:00 pm and will be a closed event. The event and reception will open to attendees Damaty, E.J. Rose, D.H. Fishbein, J.W. VanMeter. Georgetown Univ. and Penn State. (407.3) at 6:00 pm.

12 SATURDAY NUTRITION

5:00 Fuzhuan Tea Reverses Western Diet-Induced Arterial 5:00 Consequences of Maternal Iron-Deficiency: Fetal Stiffness in Mice. D. Lee, M. Battson, D. Jarrell, K. Anemia, and Hypoxia in Select Tissues of the Sevits, T. Weir, K. Cox-York, C. Gentile. Colorado Conceptus. A. Woodman, Y. Mansour, S. Bourque. State Univ. (904.15) Univ. of Alberta. (287.3) 5:00 Carbohydrates Differentially Influence Children’s 5:00 Prebiotics and β-Glucan Affect Jejunal and Serum Efficiency during Cognitive Control Tasks. L. Raine, Alkaline Phosphatase Affinity in Weanling Pigs. N. Cohen, A. Kramer, C. Hillman, N. Khan. Univ. of M-A.N. Hayhoe, T. Archbold, M.Z. Fan. Univ. of Illinois Urbana Champaign. (679.2) Guelph, Canada. (915.38) S 5:00 Differential Relationship between Thigh and Calf 5:00 Alpha-Melanocyte Stimulating Hormone Affects Adipose A Intramuscular Adipose Tissue Depots and Indices Tissue Physiology in Broiler Chicks. S.L. Shipp, G. T of Metabolic Health in Older Overweight and Obese Wang, X. Fu, M. Cline, E. Gilbert. VPI and State Adults. R.E. Bergia, J.E. Kim, W.W. Campbell. Univ. (915.25) Purdue Univ. (904.4) 5:00 Multiple Vitamins, Not Glutamine-Supplemented 5:00 The Fat Content of Milk Does Not Affect the Plasma Resuscitation Fluid Improves Intestinal Integrity and Glucose and Insulin Responses to a Meal. J. Li, E. Alters Systemic Inflammatory Mediators in Rats with Janle, W.W. Campbell. Purdue Univ. (904.5) Trauma-Hemorrhagic Shock. Y.H. Lin, H-C. Lo, T-C. 5:00 Muscadine Grape (Vitis rotundifolia and Wine Su. Fu Jen Catholic Univ. and Changhua Christian Phytochemicals Mitigates Dextran Sulfate Sodium- Hosp., Taiwan. (915.32) Induced Colitis in Mice. R. Li, A.K. Sandhu, C. Gao, 5:00 Effects of Choline Deficiency on Composition of Sow’s L. Gu. Univ of Florida and Illinois Inst. of Technol. Milk. A.T. Mudd, S.K. Johnson, L.S. Alexander, C.M. (1158.3) Getty, R.N. Dilger. Univ. of Illinois, Urbana. (915.7) 5:00 Coconut Oil Supplementation: An Innovative Strategy 5:00 Maternal Consumption of a Diet Lacking Omega-3 for Cardiovascular Disease Risk Reduction. C. Fatty Acids during Development Alters Pup Behavior Thompson-Felty, C.S. Johnston, A. Ryder. Arizona and Brain Metabolism Later in Life. C. Jackson, M. State Univ. (904.19) Alhado, E. Gonzales, J. Shumake, D. Barrett, F. 5:00 Incorporation of Almonds in a Cholesterol-Lowering Diet Gonzalez-Lima, M.A. Lane. Texas State Univ. and Improves Non-ABCA1-Mediated Cholesterol Efflux in Univ. of Texas at Austin. (915.3) Normal Weight Adults. C.E. Berryman, J.A. Fleming, 5:00 Enriching the Maternal Diet in Long Chain n-3 P.M. Kris-Etherton. Penn State. (293.2) Polyunsaturated Fatty Acids Alters Lipid Metabolites 5:00 Choline and Its Metabolites Are Differentially Associated and Adiposity in Broiler Chicks. R. Beckford, S. with Cardiometabolic Risk and Cardio- and Cerebro- Howard, S. Das, A. Tester, S. Campagna, J. Whelan, vascular Disease. A.J. Roe, A.H. Lichtenstein, I.H. J. Wilson, B. Voy. Univ. of Tennessee, Knoxville and Rosenberg, E.J. Johnson, T.M. Scott. Univ. of Idaho Univ. of Georgia. (124.1) and USDA at Tufts Univ. (904.18) 5:00 Time-Restricted Feeding of a High-Fat Diet Reduces 5:00 Choline Supplementation Improves Behavioral Aspects Adiposity and Inflammatory Cytokine Production in of Mice Exposed to Ethanol In Utero. E. Pjetri, N. Mice. S. Sundaram, L. Yan. USDA, Grand Forks. Surzenko, C.A. Munson, S.H. Zeisel. Univ. of North (915.31) Carolina at Chapel Hill, Kannapolis. (679.3) 5:00 Activation of Ubiquitin-Proteasome System Components 5:00 EGCG Decreases Mortality in a Dose-Dependent in Heat-Stressed Pig Skeletal Muscle. L.D. Zhao, Z. Fashion but Does Not Improve Cognition in Aged Zhang, G. Xie, J.T. Selsby, L.H. Baumgard, R.P. Mice. B.D. Pence, T.K. Bhattacharya, J.L. Rytych, Rhoads. Virginia Tech and Iowa State Univ. (915.34) P. Park, J.M. Allen, Y. Sun, R.H. McCusker, K.W. 5:00 Metabolic and Increased Adiposity in Kelley, R.W. Johnson, J.S. Rhodes, J.A. Woods. a Mouse Model of Chronic Gestational Alcohol Univ. of Illinois Urbana-Champaign. (407.1) Exposure. R.M. Amos-Kroohs, D.W. Nelson, C-L.E. 5:00 Relation of Total Sugars and Fructose-Containing Yen, S.M. Smith. Univ. of Wisconsin-Madison. (287.5) Sugars with Risk of Cardiovascular Disease: A 5:00 Food Insecurity Is Associated with Faster Cognitive Systematic Review and Meta-analysis of Prospective Decline: Boston Puerto Rican Health Study. J. Wong, Cohort Studies. T.A. Khan, S. Blanco-Mejia, R. T. Scott, P. Wilde, Y. Li, K.L. Tucker, X. Gao. Brigham de Souza, C.W.C. Kendall, J.L. Sievenpiper. St. and Women’s Hosp., Tufts Med. Ctr., Friedman Sch. Michael’s Hosp., Toronto, Univ. of Toronto, McMaster of Nutr. Sci. and Policy, Tufts Univ., Univ. of South Univ., Hamilton, ON and Univ. of Saskatchewan, Florida, Univ. of Massachusetts Lowell and Penn Canada. (904.7) State. (273.3) 5:00 Metabolism of Uniformly Labelled 13C-Eicosapentaenoic 5:00 HomeStyles: Recruitment Strategies for a Childhood Acid and 13C-Arachidonic Acid during Healthy Aging. Obesity Prevention Randomized Controlled Trial. J.T. P. Léveillé, R. Chouinard-Watkins, S. Cunnane, Martin-Biggers, C. Delaney, M. Koenings, C. Byrd- J.T. Brenna, M. Plourde. Univ. of Sherbrooke, Res. Bredbenner. Rutgers Univ. (422.2) Ctr. on Aging, Sherbrooke, Laval Univ., Canada and 5:00 Food Label Use Improves Dietary Quality and Mediates Cornell Univ. (1156.5) Improved Glycemic Control in Latinos with Type 5:00 Gene Expression of Vitamin D Regulatory Enzymes 2 Diabetes: The DIALBEST Trial. G. Kollannoor in Renal Tissue of Growing Pigs Is Modulated by Samuel, F.M. Shebl, S. Segura-Pérez, J. Chhabra, Maternal Dietary Vitamin D Concentrations. L. S. Vega-López, R. Pérez-Escamilla. Yale Sch. of Amundson, T. Crenshaw. Univ. of Wisconsin- Publ. Hlth., Hispanic Hlth. Council, Harford, CT, Madison. (287.2) Hartford Hosp. and Arizona State Univ. (422.5)

13 NUTRITION SATURDAY

5:00 Cross-Country Comparison of the Acceptability of 5:00 The Usual Nutrient Intakes of U.S. Children and a Social Support Behavior Change Strategy to Adolescents by Milk Drinking Behavior. Y. Zhao, R. Improve Adherence to Antenatal Calcium and Bailey, C. Weaver, G. McCabe, H. Eicher-Miller Iron-Folic Acid Supplementation. S. Martin, M. Purdue Univ. (899.2) Omotayo, G. Chapleau, R. Stoltzfus, Z. Birhanu, S. 5:00 Food Security: Motivations to Volunteer in Food Rescue Ortolano, K. Dickin. Cornell Univ. and Jimma Univ., Nutrition. T.Y. Mousa, J.H. Freeland-Graves. Univ. of Ethiopia. (422.7) Texas at Austin. (899.5) 5:00 The Impact of Nutrition Label Usage on Food Selection 5:00 Usual Dietary Intake among Children 2-5 Years in a and Consumption in a University Dining Setting. M.J. Community at High Risk for Obesity: Comparison Christoph, B.D. Ellison. Univ. of Illinois at Urbana- to Age-Matched NHANES Data, 2009-2012. B.R. Champaign. (422.8) Markides, S.H. Crixell, L. Biediger-Friedman. Texas 5:00 Women’s Empowerment and Food Security Status: A State Univ. (901.13) Global Comparative Study of Women Living in Rural 5:00 Acculturation, Diet and Psychological Health of Asian and Urban Areas. K. Sinclair, D. Ahmadigheidari, D. International Students at the University of Delaware. Dallmann, H. Melgar-Quiñonez. McGill Univ., Ste. H. Jiang. Purdue Univ. (901.25) Anne de Bellevue, QC. (149.2) 5:00 Comparing the Food Environment of Native American 5:00 Marginal Food Insecurity Is Associated with Increased Tribal Areas to That of Non-tribal Areas in California. Sodium and Decreased Fruit Consumption in Y. Shen, D. Antiporta, S. Kodish, V.M. Oddo, Mothers and Toddlers from Low-Income Households. G. Chodur, J.C. Jones-Smith. Johns Hopkins M. Spiker, K. Hurley, Y. Wang, R. Arbaiza, M. Black. Bloomberg Sch. of Publ. Hlth. (1151.2) Johns Hopkins Bloomberg Sch. of Publ. Hlth. and 5:00 Impact of Folic-Acid Intervention and MTHFRC677T Univ. of Maryland Sch. of Med. (149.4) Gene Polymorphism on All-Cause Mortality 5:00 Strong Interpersonal Relationships Buffer the Impact of Associated with Elevated Serum Homocysteine Chaos on Quality of Family Meal Interactions in Food- Levels in Chinese Adults with Hypertension. B. Xu, Insecure Households. T.N. Rosemond, C. Blake, J. X. Kong, R. Xu, M. Zhao, Y. Song, C. Zhang, T. Yu, L. Bernal, M.P. Burke, E.A. Frongillo. Univ. of South Liu, F. Fan, Y. Zhang, X. Qin, G. Tang, B. Wang, F.F. Carolina, Univ. Simon Bolivar, Venezuela and USDA, Hou, Y. Huo, J. Li. River Hill High Sch., Clarksville, Alexandria, VA. (149.6) MD, Peking Univ. First Hosp., Beijing, Nanfang Hosp., 5:00 Ethnic Differences in Cumulative Exposure to Food Southern Med. Univ., Guangzhou and Anhui Med. Insecurity and Risk of Childhood Asthma. L.D. Univ., China. (422.3) Mangini, Y. Dong, M.D. Hayward, M.R. Forman. The 5:00 Longitudinal Quality of Life Improvement after a Family- Univ. of Texas at Austin. (273.1) Based Lifestyle Intervention in Youth with Obesity. 5:00 Household Food Insecurity Access Scale and Household S.R. Engebretsen, K. Briggs Early, R. Sorrells, J.P. Food Insecurity Access Prevalence as Predictor Yi-Frazier, M. Sanchez, K. Gottlieb, B.L. Gonzalez, of Stunted Child and Overweight/Obese Mother in B. Lopez. Pacific Northwest Univ. of Hlth. Sci., Seattle Urban Indonesia. T. Mahmudiono, D.R. Andrias, T.S. Children’s Res. Inst. and Yakima Valley Mem. Hosp., Nindya, H. Megatsari, R. Rosenkranz. Kansas State WA. (422.4) Univ. and Univ. Airlangga, Indonesia. (273.8) 5:00 Understanding Acceptance, Compliance, and Utilization 5:00 The Relationship between Weight Loss Advice from of Micronutrient Powder in Northern Nigeria – Friends on Self-Perception of Weight and Eating Informing Implementation through Formative Habits. T. Thibodeau, I. van Woerden, P. Ohri- Research. S.R. Kodish, C.L. Ejembi, T. Osunkentan, Vachaspati, J. Huberty, M. Bruening. Arizona State A. Imohe, P. Mathema. Johns Hopkins Bloomberg Univ. (408.2) Sch. of Publ. Hlth., Ahmadu Bello Univ., Nigeria and 5:00 Promotion of Drinking Water among Latino Immigrant UNICEF Nigeria. (422.6) Youth. N. Barrett, U. Colón-Ramos, I. Rivera, W.D. 5:00 Differential Associations of Food Insecurity Risk on Evans, M. Edberg. George Washington Univ. Milken Dietary Intake-Frequency among Parents and Their Inst. Sch. of Publ. Hlth. and Rivera Group Inc., Adolescent Children. E. Calloway, T. Smith, C. Washington, DC. (408.3) Pinard, A. Oh, L. Nebeling, E. Hennessy, A. Yaroch. 5:00 Nutrient Intake among Overweight/Obese Hispanic Gretchen Swanson Ctr. for Nutr., Omaha and NCI, Women Based on Type 2 Diabetes Diagnosis Status. NIH. (149.1) M. Arias-Gastelum, N.M. Lindberg, A.G. Rosales, 5:00 High Household Food Insecurity Impacts Dietary M. Petrovic, E.S. LeBlanc, V.J. Stevens, T.J. Kapka, Patterns in Rural and Urban American Indian Families R.T. Meenan, S. Vega-López. Arizona State Univ., with Young Children. E. Tomayko, K. Mosso, K. Kaiser Permanente Ctr. for Hlth. Res., Portland and Cronin, R. Prince, A. Adams. Univ. of Wisconsin- Virginia Garcia Mem. Hlth. Ctr., Hillsboro, OR. (408.4) Madison. (149.8) 5:00 Associations between Dysfunctional Eating Behaviors 5:00 Are Monthly Food Insecurity Assessments Necessary? and Cardiovascular Risk among Latinos. A.A. Lopez- A Longitudinal Analysis in Rural Zambia. M. Na, Cepero, C.M. Frisard, S.C. Lemon, M.C. Rosal. B.L. Caswell, S.A. Talegawkar, A. Palmer. Johns Univ. of Massachusetts Med. Sch. (408.6) Hopkins Bloomberg Sch. of Publ. Hlth. and George 5:00 Availability and Price of Fruits and Vegetables at Food Washington Univ. (273.6) Retailers in Western Massachusetts Counties. Q. Jiang, J. Burdick, J. Chaiken, S. Walsh, N. Cohen. Univ. of Massachusetts Amherst. (129.3)

14 SATURDAY NUTRITION

5:00 A More Efficient Method of Assessing Corner Store 5:00 Dried Plums Modify Fecal Short Chain Fatty Acid Healthfulness. R. DeWeese, M. Todd, A. Karpyn, Concentrations and Gene Expression in a Model M. Yedidia, M. Kennedy, M. Bruening, C. Wharton, of Colon Carcinogenesis. D.V. Seidel, K.K. Hicks, P. Ohri-Vachaspati. Arizona State Univ., Univ. of S.S. Taddeo, M.A. Azcarate-Peril, R.J. Carroll, N.D. Delaware and Rutgers Univ. (129.5) Turner. Texas A&M Univ. and Univ. of North Carolina 5:00 What Do Parents and Children Talk about While at Chapel Hill. (147.3) Grocery Shopping? A Content Analysis of Shopping 5:00 Apiaceous and Cruciferous Vegetables Fed in the Trips. E. Calloway, A. Pritchard, C. Roberts-Gray, S. Post-initiation Stage Reduce Colonic Precancerous S Sweitzer, M. Briley. Gretchen Swanson Ctr. for Nutr., Lesions and the Cancer Marker A Omaha, Univ. of Texas at Austin and Third Coast DCLK1, and Alter the miRNA Expression Profile in T Res., Galveston. (129.6) 1,2-Dimethylhydrazine-Treated Rats. S. Kim, S.P. 5:00 E-Mechanic Exercise Interventions Eliminate the Trudo, D.D. Gallaher. Univ. of Minnesota, St. Paul Unexpected Association between Weight Gain and a and Univ. of Arkansas Sch. of Human Envrn. Sci. Healthy Food Environment. C.A. Myers, S.T. Broyles, (147.4) T.S. Church, C.K. Martin. Pennington Biomed. Res. 5:00 Dietary Tomato Reduces Castration-Resistant Prostate Ctr., Baton Rouge. (1151.7) Cancer Burden in the TRAMP Model. J.W. Smith, J.L. 5:00 Perceived Benefits of Livestock Ownership among Rowles III, R.J. Miller, S.K. Clinton, W.D. O’Brien; Female Smallholder Farmers of Mixed HIV Status in Jr., J.W. Erdman; Jr. Univ. of Illinois at Urbana- Nyanza Province, Kenya. A. Maranga, S.E. Dumas`, Champaign and The Ohio State Univ. (147.1) P.E. Mbullo, P. Wekesa, M. Onono, S.L. Young. 5:00 The Effect of Oil Palm Phenolics on Pancreatic Ductal Cornell Univ. and Kenya Med. Res. Inst. (KEMRI), Adenocarcinoma in Transgenic Mouse Model. N.H. Nairobi. (273.2) Razalli, P. Gowthaman, N. Saadat, S. Vemuri, A. 5:00 Food Insecurity Is Associated with Depression and Stress Goja, R. Sambanthamurthi, S.V. Gupta. Wayne among a Cohort of Pregnant Kenyan Women of Mixed State Univ. and Malaysian Palm Oil Bd., Kajang. HIV Status. I. Tsai, N.R. Krumdieck, S. Collins, E.M. (147.2) Widen, P. Wekesa, M. Onono, S.L. Young. Cornell 5:00 Consumption of Total and Individual Sugars, Sugary Univ., Weill Cornell Med., Columbia Univ. Med. Ctr. Foods and Sugary Beverages in Relation to and Kenya Med. Res. Inst., Kisumu. (273.4) Adiposity-Related Cancer Risk in the Framingham 5:00 It’s Not How Much Your Spend, It’s Where You Spend Offspring Cohort (1991-2013). N. Makarem, Y. Lin, It: How Consumer Behavior Predicts Dietary Energy E.V. Bandera, P. Jacques, N. Parekh. NYU, Rutgers Density. A. Massedge, J.A. Vernarelli. Fairfield Univ. Univ. and USDA at Tufts Univ. (42.1) (129.4) 5:00 Effect of Short-Chain Fatty Acid Acetate on Colon 5:00 High Overweight/Obesity Risk among Children Enrolled Cancer. M. Sahuri Arisoylu, J.D. Bell. Univ. of in Michigan Migrant and Seasonal Head Start Westminster, U.K. (42.7) Programs, 2012. C. Nance-Panek, S. Song, Y.M. 5:00 Excess Dietary Iron Modulates Intestinal Tumorigenesis. Lim, E.T. Crockett, W.O. Song. Michigan State Univ. L. Glosser, J. Swain. Case Western Reserve Univ. (901.9) (1167.9) 5:00 Physical Activity and Inactivity and Its Association with 5:00 Dietary Supplementation with Tart Cherries for Overweight and Obesity on Children and Adolescents Prevention of Inflammation-Associated Colorectal between 10 to 14 Years Old. I.Y. Pantoja, X. Cancer in Mice. A. Hunter, D. Larson, S. Phatak, K. Sandoval, J.O. Talavera, M. Pérez. UNAM, Univ. Hintze, A. Benninghoff. Utah State Univ. (1167.12) Iberoamericana and Mexican Soc. Security Inst., 5:00 Protective Effect of Betaine against Liver Steatosis Mexico City. (1151.9) Involves Depletion of Homocysteine via Upregulation 5:00 Cranberry Extract Initiates Intrinsic Apoptosis in HL-60 of Betaine-Homocysteine Methyltransferase. C.W. Cells by Increasing Bad Activity through the Inhibition Ahn, D.S. Jun, J.D. Na, Y.J. Choi, Y.C. Kim. Seoul of Akt Phosphorylation. R. Mansouri, S.S. Percival. Natl. Univ. (691.19) Univ. of Florida. (147.8) 5:00 Genetic Background Determines Anthocyanin Effects

5:00 Effect of 1,25(OH)2D in Regulating Glutamic-Oxaloacetic on Glutathione Redox Balance. K.M. Norris, R. Transaminase 1 and Redox Balance during Breast Pazdro. Univ. of Georgia. (691.27) Cancer Progression. X. Zhou, T. Wilmanski, D. 5:00 Unfermented and Fermented Cocoa Extracts as Teegarden. Purdue Univ. (42.5) Inhibitors of Pancreatic α-Amylase, α-Glucosidase, 5:00 Microenvironment Folate Stress Promotes Warburg- and Pancreatic Lipase. C. Ryan, L. Ye, S. O’Keefe, Metabolic Switched-Cancer Stem Cell Signaling A.P. Neilson. Virginia Tech. (691.30) Network and Stemness Features to Mediate Invasion 5:00 The Effects of Dietary Cocoa Powder on Inflammatory and Metastasis of Lung . W-J. Chen, R-F.S. Markers and Catalase Activity in Participants with Huang. Fu-Jen Catholic Univ., Taiwan. (147.7) Type 2 Diabetes following a Fast Food Style Meal 5:00 Inactivation of Pyruvate Dehydrogenase Complex Challenge. M. Foster, N. Betts, D. Fu, T. Lyons, A. Mediates the Selective Effects of Butyrate on Basu. Oklahoma State Univ. and Queen’s Univ. of Colorectal Cancer Cells. A. Han, N. Bennett, Belfast. (1174.14) A. MacDonald, M. Johnstone, J. Whelan, D.R. 5:00 Dried Plum Consumption Improves Antioxidant Capacity Donohoe. Univ. of Tennessee, Knoxville. (42.8) and Reduces Inflammation in Postmenopausal Women. M. Nakamichi-Lee, S. Hooshmand, M. Kern, A. Ahouraei, M.Y. Hong. Sch. of Exer. & Nutr. Sci., San Diego State Univ. (1174.19)

15 NUTRITION SATURDAY

5:00 Lycopene Inhibits Amyloid-β25-35-Induced Apoptosis by 5:00 Validating Polyphenol Intake Estimates from a Food- Decreasing Intracellular and Mitochondrial Ros Levels Frequency Questionnaire Using Repeated 24-Hour in Human Neuronal SH-SY5Y Cells. S. Hwang, J.W. Dietary Recalls and a Unique Method of Triads Lim, H. Kim. Col. of Human Ecol., Yonsei Univ., South Approach with Two Biomarkers. N. Burkholder- Korea. (404.5) Cooley, S. Rajaram, E. Haddad, G.E. Fraser, K. Oda, 5:00 The Heat Shock Protein 70 Is a Novel Target for K. Jaceldo-Siegl. Loma Linda Univ. (690.6) Nobiletin in Human Colon Cancer Cells. Z. Gao, J. 5:00 Intake of 2 Eggs for Breakfast Increases Plasma Lutein Zheng, X. Wu, K. Dimova, S. Scordilis, H. Xiao. Univ. Concentration in Association with Increased Large of Massachusetts Amherst and Smith Col. (691.2) HDL and Zeta Potential as Compared to an Oatmeal 5:00 Modulation of Cerebral Activity Induced by α-Casozepine, Breakfast. A.C. Missimer, S. Hu, Y. Luo, C.N. Blesso, a Benzodiazepine-Like Peptide Derived from Bovine M-L. Fernandez. Univ. of Connecticut. (690.7) Casein. S. Benoit, C. Chaumontet, Cakir-Kiefer, D. 5:00 Korean Red Ginseng Extract Inhibits p53-Dependent Tomé, L. Miclo. AgroParisTech, INRA, Univ. Paris- Apoptosis In Helicobacter pylori- Infected Gastric Saclay and Univ. de Lorraine-Nancy, France. (125.4) Epithelial Cells. HJ. Kang, J.W. Lim, H. Kim. Col. of 5:00 Long-Term Feeding of a Soy-Protein-Based Diet Human Ecol., Yonsei Univ., South Korea. (691.24) Improves Trabecular and Cortical Bone Outcomes 5:00 Cyanidin, a Natural Anti-glycation Agent, Inhibits in Low-Fit, Intact and Ovariectomized Female Rats. Methylglyoxal- and Glucose-Mediated Protein M.W. Richard, L.C. Ortinau, T.M. Zidon, P.S. Hinton, Glycation In Vitro. T. Suantawee, H. Cheng, S. V. Vieira-Potter. Univ. of Missouri-Columbia. (125.3) Adisakwattana. Chulalongkorn Univ., Thailand and 5:00 Collagen Peptides Derived from Alaska Pollock Skin LSU Sch. of Vet. Med. (692.9) Protect against TNFα-Induced Dysfunction of Tight 5:00 Xylobiose Ameliorates Hyperglycemia and Dyslipidemia Junctions in Caco-2 Cells. Q. Chen, B. Li, I. Martin, via Regulating Hepatic Lipogenic Genes in db/db J.B. Blumberg, C-Y.O. Chen. Ocean Univ. of China, Mice. E. Kim, E. Lim, S. Jung, S-H. Yoo, Y. Kim. USDA at Tufts Univ. and State Univ. of Campinas, Ewha Womans Univ., TS Corp., Inchon and Sejong Brazil. (125.5) Univ., South Korea. (692.10) 5:00 Cocoa Increases Postprandial GLP-1 Response in 5:00 The Effect of Oil Palm Phenolics on Urinary Metabolomic Adults with Impaired Glucose Tolerance. K. Strat, Profile In Atherogenic Diet-Induced Rat Model of B.M. Davy, M.W. Hulver, K.P. Davy, A.P. Neilson. Alzheimer’s Disease. Y. Wu, V. Srirajavatsavai, R. Virginia Tech. (428.5) Sambanthamurthi, S.V. Gupta. Wayne State Univ. 5:00 Green Tea Extract Lowers NFκB-Mediated Inflammation and Malaysian Palm Oil Board, Kuala Lumpur. during Nonalcoholic Steatohepatitis in Mice Fed a High- (692.21) Fat Diet Consistent with Reduced Toll-Like Receptor-4 5:00 Neurorescue Effect of EGCG in an Animal Model Signaling. J. Li, C. Chitchumroonchokchai, J.B. of Parkinson’s Disease. Q. Xu, M. Langley, A. Kim, M.V. Moller, R.S. Bruno. The Ohio State Kanthasamy, M. Reddy. Iowa State Univ. (1174.11) Univ. (269.2) 5:00 Anti-proliferative and Anti-inflammatory Action 5:00 Anti-inflammatory and Anti-cancer Effects of the Colonic of Blueberry Polyphenols in HIG-82 Rabbit Metabolites of Polymethoxyflavone. M. Wang, X. Wu, Synoviocytes. S. South, J. Lucero, V. Imrhan, C. M. Song, H. Xiao. Univ. of Massachusetts Amherst. Prasad, P. Vijayagopal, S. Juma. Texas Woman’s (269.1) Univ. (1174.20) 5:00 The Impact of Limonin on Gut Microbiota. M. Gu, J. Sun, 5:00 Blueberry Supplementation Alters Biomarkers of C. Qi, K.X. Cai, T. Goulette, Y.M. Song, M.X. You, D. Oxidative Stress in High-Fat Fed Rats. K.I. Keirsey, Sela, H. Xiao. Univ. of Massachusetts Amherst and S. Lee, C.B. de La Serre, J.G. Fischer. Univ. of Jiangnan Univ., China. (416.5) Georgia. (1174.23) 5:00 Effect of Frequent Broccoli Intake on Rat Gut Microbiota 5:00 Tannase-Treated Grape Pomace Attenuates IL-1β- Metabolism and Composition. Y. Wang, X. Liu, M.J. Induced Inflammation in Caco-2 Cells. I. Martin, G. Miller, E.H. Jeffery. Univ. of Illinois, Urbana. (690.13) Macedo, J. Blumberg, C-Y.O. Chen. USDA at Tufts 5:00 Efficacy of Chewing Gum as a Delivery System for Univ. and State Univ. of Campinas (UNICAMP), Water and Fat Soluble Vitamins. W.Y.H. Khoo, J.D. Brazil. (269.4) Lambert. Penn State. (690.18) 5:00 Gamma Tocotrienol Suppresses NLRP3 Inflammasome 5:00 Acute Bioavailability of (Poly)phenolic Content of by Dual Mechanism of A20-Mediated Priming Different Varieties of Vaccinium spp. in Ovariectomized Inhibition and AMPK/Autophagy Axis Activation. Y. Rats. M. Maiz, D.P. Cladis, P.J. Lachcik, E.M. Janle, Kim, S. Chung. Univ. of Nebraska-Lincoln. (269.5) M.A. Lila, M.G. Ferruzzi, C.M. Weaver. Purdue Univ. 5:00 Protective Effect of Pteropyrum scoparium and Oxalis and North Carolina State Univ., Kannapolis. (690.20) Corniculata against Streptozotocin- Induced Diabetes 5:00 Delta and Gamma Tocotrienol Attenuate NLRP3 in Rats. I.R.S. Al-Qalhati, M. Waly, Z. Al-Attabi, L.K. Inflammasome Activation in J774 Macrophages via Al-Subhi. Sultan Qaboos Univ., Oman. (1176.4) NFκB-Dependent Priming Inhibition. T. Buckner, Y. 5:00 Avenanthramides 2c, 2f and 2p Regulate Osteoblast Kim, S. Chung, M. Engel. Univ. of Nebraska-Lincoln. Gene Expression and Survival In Vitro. G.G. (1174.6) Pellegrini, C.C. Morales, J. Johnson, T.C. Wallace, T. Bellido. Indiana Univ. Sch. of Med., PepsiCo Inc., Barrington, IL and Natl. Osteoporosis Fndn., Arlington, VA. (1174.9)

16 SATURDAY NUTRITION

5:00 Effects of Acute n-3 Fatty Acid Administration on 5:00 Obesity-Breast Cancer Interactions: Effects of Cardiac Lipid Metabolism and Ca2+ Homeostasis Adipocytes on Breast Cancer Cells and Preventive during Ischemia-Reperfusion. H. Zirpoli, N. Quadri, Effects of Omega 3 Fatty Acids. S.A. Alhaj, A. K.M. O’Shea, R. Ananthakrishan, M. Abdillahi, R. Aljawadi, L. Ramalingam, N. Moustaid-Moussa. Rosario, R.J. Deckelbaum, R. Ramasamy. Col. Texas Tech Univ. (691.29) of P&S, Columbia Univ. Med. Ctr. and NYU Med. 5:00 Ellagic Acid and Quercetin Are High-Affinity Ligands of Ctr. (404.2) Human Peroxisome Proliferator-Activated Receptor 5:00 Dietary Small RNA Modulation of Gut Microbiota Alpha in an In Vitro Competitive Binding Assay. G. S Composition: In Silico and In Vitro Analyses. H. Sasaki, T. Luo, N.F. Shay. Oregon State Univ. (691.7) A Huang, C. Davis, L. Yu, T.T.Y. Wang. USDA, Beltsville, 5:00 Inulin Effect on Weight Loss and Associated T MD, ODS, NIH and Univ. of Maryland College Park. Parameters with the Development of Cardiovascular (416.1) Disease in Obese Adults. F.H. Castro-Sanchez, 5:00 Probiotic Lacidofil® STRONG Mitigates the Antibiotic- D.A. Ochoa-Acosta, N.G. Valenzuela-Rubio, M. Induced Alteration of the Fecal MicroRNA Signature in Dominguez-Rodriguez, J.A. Fierros-Valdez, M. Healthy Humans. A. Taibi, E.M. Comelli, S-A. Girard, Vergara-Jimenez Sch. of Nutr. and Gastron., T.A. Tompkins. Univ. of Toronto, Ctr. for Child Nutr. Autonomous Univ. of Sinaloa, Mexico. (1176.22) and Hlth., Toronto and Lallemand Hlth. Solutions, 5:00 The Effect of Fructose-Containing Sugars on Glycemic Monreal. (289.7) Control: A Systematic Review and Meta-analysis 5:00 Effects of Almonds on Cardiovascular Risk Factors in of Controlled Trials. V.L. Choo, A.I. Cozma, E. Overweight and Obese Koreans. H. Jung, C-Y.O. Viguiliouk, S. Blanco Mejia, C.W.C. Kendall, R.J. Chen, J.B. Blumberg, H-K. Kwak. Korea Natl. Open de Souza, D.J.A. Jenkins, J.L. Sievenpiper. Univ. of Univ., Seoul and Tufts Univ., Boston. (1175.5) Toronto, St. Michael’s Hosp., Toronto and McMaster 5:00 Beneficial Cardiovascular Effects of Muscadine Grape Univ., Canada. (685.5) Extract in Normotensive Female Rats. A.V. Duncan, 5:00 Higher Protein Intake Improves Sleep and Blood H.A. Shaltout, E.N. Tommasi, P.E. Gallagher, E.A. Pressure, and Influences the Relation between Tallant, D.I. Diz. Wake Forest Sch. of Med. (1175.7) Changes in Blood Pressure and Sleep during Energy 5:00 Nutritional Polyphenol Metabolites’ Kinetics in Plasma, Restriction in Middle-Aged Overweight and Obese Urine, and Saliva following Consumption by Normal, Adults. J. Zhou, J.E. Kim, W.W. Campbell. Purdue Healthy, Subjects. Y.Y. Choy, S.N. Hester, A. Univ. (415.6) Mastaloudis, S.M. Wood, R. Gray, R.P. O’Donnell, 5:00 Protection against Insulin Resistance in Obesity Is J.L. Barger, P. Quifer-Rada, R.M. Lamuela- Accompanied by Low Rates of Systemic Fatty Acid Raventós, A.L. Waterhouse. Univ. of California, Mobilization and Attenuated Markers of Fibrosis and Davis, Nu Skin Enterprises, Provo, UT, LifeGen Inflammation in Adipose Tissue. D.W. Van Pelt, A.Y. Technols., Madison, WI, Univ. of Barcelona and Inst. Wang, J.F. Horowitz. Univ. of Michigan. (291.1) of Hlth. Carlos III, Madrid. (690.2) 5:00 Lipid Emulsions, Rich in n-3 or n-9 Fatty Acids, Reverse 5:00 Soy Proteins Deficient in theα ’ Subunit of β-Conglycinin the Progression of Parenteral Nutrition-Induced and Various Glycinin Subunits Maintain the Ability Hepatic Steatosis in Mice. K-H. Huang, P.B. Smith, to Modulate Hepatic Lipid and Glucose Metabolism. A.D. Patterson, A.C. Ross. Penn State. (267.2) C. Chatterjee, J. Liu, C. Wood, C. Gagnon, E.R. 5:00 Intake of Genistein and Daidzein Ameliorates Cober, J.A. Fregeau-Reid, S. Gleddie, C. Xiao. Hlth. Adiposity and Metabolic Syndrome in High Fat Fed Canada, Agr. & Agri-Food Canada and Carleton Univ., C57BL/6JMice. T. Luo, O. Miranda, A. Adamson, Ottawa. (1175.2) N.F. Shay. Oregon State Univ. (291.5) 5:00 Green Tea Extract and Catechol-O-Methyltransferase 5:00 Dietary Linoleic Acid Increases Linoleic- and Arachidonic (COMT) Genotype Modify Fasting Serum Insulin and Acid-Derived Bioactive Lipids, Despite Not Altering Plasma Adiponectin Concentrations in a Randomized Tissue Fatty Acid Levels. S.M. Leng, H.M. Aukema. Controlled Trial of Overweight and Obese Univ. of Manitoba and CCARM, Winnipeg. (130.7) Postmenopausal Women. A. Dostal, H. Samavat, 5:00 The Effect of Dietary Protein on Bone during Weight L. Espejo, A. Arikawa, N.R. Stendell-Hollis, M.S. Loss: A Meta-Analysis and Systematic Review. C.S. Kurzer. Univ. of Minnesota, St. Paul, Univ. of North Wright, J. Li, W.W. Campbell. Purdue Univ. (415.4) Florida and Central Washington Univ. (289.1) 5:00 Effects of Dietary Protein and Fiber at Breakfast on 5:00 Effect of 3 Probiotic Strains on Bile Acids and Glucose Postprandial Appetite, Neural Responses to Visual Metabolism in Healthy Adults: A Randomized, Food Stimuli, and Ad Libitum Energy Intake at Lunch Double-Blind Placebo-Controlled Crossover Study. in Overweight Adults. R.D. Sayer, A. Amankwaah, T. Culpepper, C.C. Rowe, C. Nieves, S-A. Girard, G. Tamer; Jr, N. Chen, A. Wright, J. Tregellas, M. M. Christman, S. Chung, T.A. Thompkins, B. Cornier, D. Kareken, T. Talavage, M. McCrory, W. Langkamp-Henken. Univ. of Florida, Lallemand Campbell. Weldon Sch. of Biomed. Engin., Purdue Hlth. Solutions, Montreal, MCC Stat. Consulting LLC, Univ., Univ. of Colorado Sch. of Med., Anschutz Med. Gainesville and Univ. of Nebraska-Lincoln. (289.6) Campus, Indiana Univ. Sch. of Med. and Georgia 5:00 Inhibition of High Glucose-Induced Diabetic Retinal State Univ. (418.7) Angiogenesis by Dietary Compound Chrysin. M. Kang, Y-H. Kang. Hallym Univ., South Korea. (691.16)

17 NUTRITION SATURDAY

5:00 DHA Is More Potent Than EPA in Attenuating 5:00 Dietary α-Linolenic Acid-Rich Flax Oil Elevates Renal Cardiometabolic Risk in Men and Women: A and Hepatic Docsosahexaenoic Acid-Derived Randomized Double-Blind, Placebo-Controlled Bioactive Lipids. J.G. Devassy, T. Yamaguchi, N. Crossover Trial. J. Allaire, P. Couture, A. Charest, Ibrahim, M. Gabbs, T. Winter, A. Ravandi, H.M. M. Leclerc, J. Marin, M-C. Lépine, A. Tchernof, B. Aukema. Univ. of Manitoba and St. Boniface Hosp. Lamarche. Univ. Laval and Univ. Inst. of Cardiol. and Res. Ctr., Winnipeg. (267.5) Pneumol. of Québec. (130.1) 5:00 Modulation of Omega-3 Fatty Acid Profile in the Duck 5:00 Effects of Hormone Therapy on the Association between Liver by Various Dietary Fats. X. Chen, X. Du, J. Erythrocyte Levels of n-3 Polyunsaturated Fatty Acids Shen, L. Lu, W. Wang. Kansas State Univ., Zhejiang and Depression in Postmenopausal Women. Y. Jin, Y. Acad. Agr. Sci. and Zhejiang Zhuowang Agr. Sci-Tech Park. Hanyang Univ., South Korea. (267.3) Ltd. Co., China. (1163.18) 5:00 Adipocyte-Specific Ablation of Long-Chain Acyl-CoA 5:00 Dairy Milk Components Differentially Affect Synthetase-4 in Mice Protects against Diet-Induced Gastrointestinal Health Markers in C57Bl/6 Mice. T.R. Obesity-Associated Decreases in White Adipocyte Price, S.A. Baskaran, K. Moncada, Y. Minamoto, C. Oxygen Consumption and Whole Body Energy Klemashevich, A. Jayaraman, J.S. Suchodolski, Expenditure. E.A. Killion, D. Kong, A.S. Greenberg. R.L. Walzem. Texas A&M Univ. (685.2)

USDA at Tufts Univ. and Tufts Univ. Sackler Sch. of 5:00 Impact of Vitamin D Status and High-Dose Vitamin D3 Grad. Biomed. Sci. (267.8) Administration on the Plasma Metabolome in Critically 5:00 The Relationship between Dietary Protein Intake Ill Adults. K. Perry-Walker, D.I. Walker, J.A. Alvarez, Distribution and Lean Mass Loss in Free-Living Older J.E. Han, J.L. Jones, L. Hao, S. Li, K. Uppal, V.T. Adults: Effect of Sex and Total Protein Intake. S. Tran, L. Brown, V. Tangpricha, G.S. Martin, D.P. Farsijani, J.A. Morais, H. Payette, P. Gaudreau, B. Jones, T.R. Ziegler. Med. Col. of Georgia and Emory Shatenstein, K. Gray-Donald, S. Chevalier. McGill Univ. (271.3) Univ., Univ. of Sherbrooke, CHUMRC, Montreal and 5:00 Genes Associated with Amino Acid Sensing in Human Univ. of Montreal. (415.1) Skeletal Muscle Are Altered by Amino Acid Availability 5:00 Postprandial Glycemic and Insulinemic Responses to and Acute Lysosomal Perturbation. T.G. Graber, M.S. Common Breakfast Beverages Consumed with a Borack, P.T. Reidy, E. Volpi, B.B. Rasmussen. Univ. Standard Meal in Overweight and Obese Individuals. of Texas Med. Branch. (430.5) J. Li, E. Janle, W.W. Campbell. Purdue Univ. (1160.9) 5:00 Development of Nonalcoholic Fatty Liver in Superoxide 5:00 Ablation of BCO2 Leads to Increased Susceptibility to Dismutase-1 Knockout Mice Was Associated with High Fat Diet-Induced Metabolic Disorders in Mice. L. Altered Expression of Hepatic Fibroblast Growth Wu, X. Guo, A. Davis, T.P. Soh, S. Clarke, E. Lucas, Factor-21. D. Chakraborty, X.G. Lei. Cornell B. Smith, W. Wang, D. Medeiros, D. Lin. Oklahoma Univ. (267.7) State Univ., Kansas State Univ. and Univ. of Missouri- 5:00 Assessing the Role of Saturated Fats in Adipose Tissue Kansas City. (271.5) Inflammation. M. Morgan-Bathke, W. Faubion, M. 5:00 Leucine in the Presence of Inflammation Alters BCAA Jensen. Mayo Clin. and Viterbo Univ., WI. (130.2) Metabolism in Human Myotubes. E.S. Riddle, H. 5:00 Obesity and Dietary Fat Modulate HDL Function Roman, M. Ahsan, H. Shin, A. Thalacker-Mercer. in Adolescents: Results from a Cross-Sectional Cornell Univ. (430.7) Analysis and a Randomized, Placebo-Controlled, 5:00 Altered Fatty Acid Metabolism Remodels the Crossover Trial. A.M. McMorrow, M. O’Reilly, Hypothalamic Metabolome to Stimulate Feeding R.M. Connaughton, E. Carolan, D. O’Shea, F.E. Behavior in BCO2 Knockout Mice. X. Guo, L. Wu, Lithander, F.C. McGillicuddy, H.M. Roche. University T. Soh, W. Chowanadisai, S. Clarke, E. Lucas, B. Col. Dublin, St Vincent’s Univ. Hosp., Dublin and Univ. Smith, W. Wang, D. Medeiros, D. Lin. Oklahoma of Canberra. (130.6) State Univ., Kansas State Univ. and Univ. of Missouri- 5:00 Citrulline Is a More Efficient Supplement Than Arginine Kansas City. (271.6) to Increase Systemic Arginine Availability in Mice. U. 5:00 Effect of Plant Sources of Omega-3 PUFA on Mood Agarwal, I.C. Didelija, J.C. Marini. Baylor Col. of Status in Healthy Subjects: A Crossover Feeding Med. (430.6) Trial. W.M. Young. Loma Linda Univ. (130.8) 5:00 Predicting Initial Lipid Release from Masticated Tree 5:00 Meta-analysis of Saturated Fatty Acid Intake and Breast Nuts Using Mathematical Modelling. T. Grassby, Cancer Risk. H. Xia, G. Sun, S. Wang. Sch. of Publ. Y. Shen, L. Wagner, S. Beckett, W. Hall, S. Berry. Hlth., Southeast Univ., China. (1163.14) King’s Col. London. (405.6) 5:00 Effect of Stimulation to the Oral Cavity on Diet-Induced 5:00 Metabolic Control of Cell Death : The Role of Bcl-xL. Thermogenesis and the Substrate Oxidation of H-A. Park, P. Licznerski, Y. Niu, N. Mnatsakanyan, Macronutrients. Y. Hamada, N. Hayashi. Grad. P. Miranda, J. Wu, S. Sacchetti, B.M. Polster, Sch. of Decision Sci. and Technol., Tokyo Inst. of K.N. Alavian, E.A. Jonas. Yale Sch. of Med., Univ. Technol. (906.8) of Maryland Baltimore and Imperial Col. London. 5:00 Protein and Glutathione Kinetics in Protein Deficient (1162.2) Piglets with Colitis in Response to Nutritional 5:00 Use of Plasma Metabolomics at Diagnosis to Identify Interventions: Protein Repletion or N-Acetylcysteine Metabolic Pathways Associated with Pulmonary Supplementation. M. Hong, J.Y. Xiao, E. Nitschmann, Tuberculosis Clearance: A Pilot Study. E. Chong, L.J. Wykes. Sch. of Dietetics and Human Nutr., McGill J.K. Frediani, J.A. Alvarez, V. Tangpricha, H.M. Univ. (685.4) Blumberg, D.P. Jones, T. Yu, T.R. Ziegler. Emory Univ. (271.8)

18 SATURDAY NUTRITION

5:00 Effects of Exercise, Caloric Restriction and Subsequent 5:00 Consumption of Novel Thiamin-Fortified Fish Sauce Weight Regain following the Loss of Ovarian Function Improves the Thiamin Status of Rural Cambodian on Mitochondrial Respiration. R. Oljira, M. Jackman, Women of Childbearing Age and Their Children <5 R. Foright, J. Houck, G. Johnson, V. Sherk, P.S. Years. K.C. Whitfield, C.D. Karakochuk, H. Kroeun, MacLean. Univ. of Colorado Sch. of Med. (906.13) B. Chan, M. Borath, L.D. Lynd, E.C.Y. Li-Chan, D.D. 5:00 Protein Intake Is Associated with Plasma Insulin- Kitts, T.J. Green. Univ. of British Columbia, Helen Like Growth Factor 1 in Postmenopausal Women Keller Intl. - Cambodia, Ministry of Planning, Phnom but Not in Premenopausal Women. K.N. Drake, J. Penh and South Australian Hlth. and Med. Res. Inst., S Foganholo, A. Brindisi, H. Samavat, K. Sturgeon, Adelaide. (891.9) A K. Schmitz, M.S. Kurzer, A.Y. Arikawa. Univ. of North 5:00 Social Support Enhances Adherence to Antenatal T Florida, Univ. of Minnesota, Saint Paul and Univ. of Calcium and Iron-Folic Acid Supplements: Pennsylvania. (1164.3) Acceptability and Impact of Adherence Partners. S. 5:00 Early Childhood Predictors of Lifecourse BMI Latent Martin, M. Omotayo, R. Stoltzfus, K. Dickin. Cornell Class Trajectories in a Guatemalan Cohort. N.D. Univ. (150.3) Ford, M. Ramirez-Zea, R. Martorell, A.D. Stein. 5:00 Effect of Short-Term Maternal Supplementation with Emory Univ. and Inst. of Nutr. of Central America and Small Amounts of Vitamin A or Beta-Carotene on Panama (INCAP), Guatemala. (33.2) Breast Milk Retinol Concentrations among Lactating 5:00 Access and Adoption of Nutrition Specific and Nutrition Filipino Women. R. Engle-Stone, A. Osei, M.F.D. Sensitive Messages in Ethiopia: A Qualitative Reario, A. Hall, J.E. Arsenault, N. Haselow, G. Lietz, Gendered Comparison. M. Min-Barron. Friedman K.H. Brown, M.J. Haskell. Univ. of California, Davis, Sch. of Nutr. Sci. and Policy, Boston. (274.1) Helen Keller Intl., NY, Newcastle Univ., U.K. and Bill & 5:00 Predicted Effects of Current and Potential Micronutrient Melinda Gates Fndn., Seattle. (150.7) Intervention Programs on Adequacy of Folate 5:00 Large-Scale Television Campaign Associated with and Vitamin B-12 Intake in a National Sample of Higher Prevalence of Exclusive Breastfeeding in Women and Young Children in Cameroon. H. Luo, Vietnam. T.T. Nguyen, S. Alayón, P.H. Nguyen, A. C.P. Stewart, K.H. Brown, R. Engle-Stone. Univ. Jimerson, N. Hajeebhoy, J. Baker, E.A. Frongillo. of California, Davis and Bill & Melinda Gates Fndn. FHI 360, Hanoi, FHI 360, Save the Children and IFPRI, (891.3) Washington, DC and Univ. of South Carolina. (274.8) 5:00 Length-for-Age and Weight-for-Age z Scores at 5:00 High Prevalence of Low Urinary Iodine among Pregnant Birth Using the World Health Organization Growth and Lactating Women of Bangladesh Does Not Standards versus the New INTERGROWTH 21st Respond to Daily Lipid-Based Nutrient Supplement Newborn Size Standards. N. Perumal, J. Shi, D. Containing 250 µg Iodine. M.K. Mridha, S.L. Matias, Bassani, A. Al-Mahmud, M.M. Islam, T. Ahmad, D. S.A. Khan, R.R. Paul, Z. Siddiqui, B. Ullah, S. Roth. Dalla Lana Sch. of Publ. Hlth., Univ. of Toronto, Hussain, R.T. Young, C.D. Arnold, K.G. Dewey. Hosp. for Sick Children, Toronto and icddr,b, Dhaka, Univ. of California, Davis, ICDDR,B, Care Bangladesh Bangladesh. (432.3) and Save the Children, Dhaka, Bangladesh. (150.4) 5:00 Determinants of Developmental Milestones in Infants 5:00 Physical Activity and Work Productivity in Response to and Young Children in Bihar, India. L. Larson, R. Iron and Iodine Double-Fortified Salt Trial in Indian Mehta, P. Kekre, P. Verma, M. Young, A. Webb Girard, Tea Estate Workers. M.M. Blakstad, J.E.H. Nevins, U. Ramakrishnan, I. Chaudhuri, S. Srikantiah, R. S. Venkatramanan, E.M. Przybyszewski, J.D. Haas. Martorell. Emory Univ. and CARE India, Patna. (44.5) Cornell Univ. and McGill Univ., Ste. Anne de Bellevue. 5:00 Oregano Essential Oil and Carvacrol Reduce (150.5) Cryptosporidium parvum Infectivity of HCT-8 Cells. 5:00 Prebiotic Diet Modulates Gut Microbial Composition and S. Gaur, T.B. Kuhlenschmidt, M.S. Kuhlenschmidt, Metabolic Functions in Metabolic Syndrome Patients: J.E. Andrade. Univ. of Illinois at Urbana-Champaign. Follow-Up of a Double Blind, Controlled, Crossover (668.12) Intervention. B. Upadhyaya, R. Juenemann, L. 5:00 Non-responsive Feeding Behaviors Are Negatively McCormack, A.R. Fardin-Kia, J. Clapper, S. Associated with Growth and Dietary Diversity at Nichenametla, B. Specker, M. Dey. South Dakota 24 Months in Rural Bangladesh. Z.T. Chowdhury, State Univ. and USDA, College Park, MD. (419.4) K.M. Hurley, M. Jahan, S. Shaikh, S. Mehra, H. Ali, 5:00 Gastrointestinal Microbial Changes following Whole A.A. Shamim, P. Christian Johns Hopkins Grain Barley and Oat Consumption in Healthy Men Bloomberg Sch. of Publ. Hlth. and JiVitA Proj., and Women. S.V. Thompson, K.S. Swanson, J.A. Bangladesh. (432.8) Novotny, D.J. Baer, H.D. Holscher. Univ. of Illinois at 5:00 An Enteropathy Score Predicts Subsequent Length Urbana-Champaign, USDA, Beltsville, MD. (406.1) Better Than Lactulose Mannitol Ratio Alone in 5:00 Three Doses of Vitamin D on Insulin Resistance and Children Enrolled in a Community-Based Randomized Osteocalcin Measures in Older Women. L.C. Pop, Trial of Complementary Food Supplements in S.H. Schneider, D. Sukumar, Y. Schlussel, S.A. Rural Bangladesh. R. Campbell, K. Schulze, S. Shapses. Rutgers Univ., Rutgers-Robert Wood Shaikh, H. Ali, S. Mehra, L. Wu, P. Christian. Johns Johnson Med. Sch. and Drexel Univ. (419.8) Hopkins Bloomberg Sch. of Publ. Hlth. and JiVitA, Bangladesh. (432.4)

19 NUTRITION SATURDAY

5:00 Modulation of Colonic Microbiota Populations by 5:00 Lean Mass Accretion Associates with Vitamin D Intake: Polyphenolic Containing Sorghum Brans May Protect A 6 Month Randomized Controlled Trial in 2-8 Year against Development of Metabolic Disease. S.K. Olds Using Fortified Foods. N.R. Brett, C.A. Parks, Lloyd, L.E. Ritchie, K.K. Hicks, M.A. Azcarate-Peril, P. Lavery, S. Agellon, C.A. Vanstone, J.L. Maguire, N.D. Turner. Texas A&M Univ. and Univ. of North F. Rauch, H.A. Weiler. Sch. of Dietetics and Human Carolina Sch. of Med. (683.4) Nutr., McGill Univ., Li Ka Shing Inst. of St. Michael’s 5:00 Pectin Feeding for 16 Weeks Improves Learning and Hosp., Univ. of Toronto and Shriners Hosp. for Memory in Young C57BL/6_J Mice: A Relationship Children, McGill Univ. (151.3) to the Gut Microbiota? L. Mailing, J. Allen, T-W. Liu, 5:00 Erythrocyte Omega-3 Long Chain Polyunsaturated T. Bhattacharya, P. Park, B. Pence, J. Rodney, G. Fatty Acids Are Associated with Lumbar Spine but Fahey, K. Swanson, J. Rhodes, J. Woods. Univ. of Not Whole Body Bone Mineral Density in Healthy Illinois at Urbana-Champaign. (683.10) Children. C.A. Parks, N.R. Brett, S. Agellon, P. 5:00 Prospective Association of Fasting Blood Glucose Levels Lavery, C.A. Vanstone, J.L. Maguire, F. Rauch, H.A. with Risk of Incident Stroke among Hypertensive Weiler. Sch. of Dietetics and Human Nutr., McGill Patients in China: Impact of Folic-Acid Intervention. Univ., Li Ka Shing Knowledge Inst. of St. Michael’s R. Xu, X. Kong, B. Xu, M. Ji, Y. Zhang, B. Wang, F.F. Hosp., Univ. of Toronto and McGill Univ., Montreal. Hou, J. Ge, Y. Huo, J. Li. River Hill H.S., Clarksville, (151.4) MD, Peking Univ. First Hosp., Beijing, Zhongshan 5:00 Eating, Feeling, and Feeding: Does Maternal Binge Hosp., Fudan Univ., China, Nanfang Hosp., So. Med. Eating Predict Use of Child Feeding Practices Univ., China. (419.6) through Emotional Responsiveness? J.A. Saltzman, 5:00 Influence of Daily and Per Meal Protein Intakes on M. Pineros-Leano, J.M. Liechty, K.K. Bost, B.H. Function and Body Composition in Frail, Obese Older Fiese. Sch. of Social Work, Univ. of Illinois, Urbana. Adults Undergoing Weight Reduction. K.N. Porter (1150.12) Starr, M.C. Orenduff, S.R. McDonald, C.F. Pieper, 5:00 Role of Human Milk Oligosaccharides in Feto-placental H.C. Mulder, K. Maloney, C.W. Bales. Duke Univ. Endothelial Function in Gestational Diabetes Mellitus. Med. Ctr. and Durham VA Med. Ctr. (419.1) E. Jantscher-Krenn, J. Aigner, U. Lam, M. van 5:00 Differences in the Infant Gut Microbiota Related to the Poppel, L. Bode, G. Desoye. Med. Univ. of Graz, Fatty Acid Composition of Human Milk: Results from Univ. of Graz, Austria and UCSD. (275.6) the GEHM Cohort. D.H. Taft, K.A. Dingess, C.J. 5:00 Mammary Gland Structure and Functional Changes Valentine, B.S. Davidson, N.J. Ollberding, D.V. in Mouse Model of Chronic Gestational Alcohol Ward, J.T. Brenna, R.J. McMahon, A.L. Morrow. Exposure. R.M. Amos-Kroohs, A.A. Cheng, R.D. Cincinnati Children’s Hosp. and Med. Ctr., Mead Clugston, T-N. Huang, C-L. Yen, W.S. Blaner, S.M. Johnson Nutr., Glenview, IL, Univ. of Massachusetts Smith. Univ. of Wisconsin-Madison and Columbia Med. Sch. and Cornell Univ. (406.7) Univ. (275.4) 5:00 Formula Milk Alters Microbial Diversity in Porcine Colon 5:00 INSIGHT Study Parenting Intervention to Prevent and Impacts Immune Response. M.K. Saraf, A.K. Childhood Obesity Improves Patterns of Dietary Bowlin, S.V. Chintapalli, K. Shankar, T. LeRoith, Exposures in Infants. E.E. Hohman, J.S. Savage, I.M. M.J. Ronis, T.M. Badger, L. Yeruva. Arkansas Paul, L.L. Birch. Penn State, Penn State Col. of Med. Children’s Nutr. Ctr., Univ. of Arkansas for Med. Sci., and Univ. of Georgia. (295.2) VA-MD Col. of Vet. Med. and LSU Hlth. Sci. Ctr., New 5:00 Calcium Absorption among Racially Diverse Pregnant Orleans. (406.8) Women. M.N.R. Lesser, L. Nguyen, J.C. King, K.O. 5:00 Impact of Almond Consumption on the Composition O’Brien, E.B. Fung. Children’s Hosp. Oakland Res. of the Gastrointestinal Microbiota of Healthy Adult Inst., Univ. of California, Berkeley and Cornell Univ. Men and Women. A.M. Taylor, K.S. Swanson, J.A. (45.1) Novotny, D.J. Baer, H.D. Holscher. Univ. of Illinois 5:00 Association between Breastfeeding, Maternal Weight at Urbana-Champaign and USDA, Beltsville, MD. Loss and Body Composition at 3 Months Postpartum. (406.5) S.A. Elliott, L.C.R. Pereira, E. Guigard, L.J. 5:00 Perceived Breastmilk Insufficiency and HIV Are McCargar, C.C.M. Prado, R.C. Bell. Univ. of Alberta. Associated with Exclusive Breastfeeding at 1 and 3 (45.4) Months among Mothers in Northern Uganda. S.L. 5:00 Standing by Human Milk through Thick and Thin: The Martin, S.M. Collins, E.M. Widen, D. Achidri, S.L. Effect of Thickeners on Human Milk Viscosity. J.K. Young. Cornell Univ., Columbia Univ. and PRENAPS Koo, L. Bode, J.H. Kim. UCSD/Rady Children’s Uganda, Gulu. (45.7) Hosp. of San Diego. (151.5) 5:00 Impact of Maternal Infection and Breast Inflammation 5:00 Using Skin Carotenoids to Assess Potential Dietary on Infant Growth in Guatemala. H.M. Wren, A.L. Changes after One Academic Year in the Shaping Leblanc, C. Li, N.W. Solomons, M.E. Scott, K.G. Healthy Choices Program. L.M. Nguyen, R.E. Koski. McGill Univ., St-Anne-de-Bellevue, Montreal Scherr, M. Dharmar, I.V. Ermakov, W. Gellermann, and CeSSIAM, Guatemala City. (45.6) L. Jahns, J.D. Linnell, C.L. Keen, S. Miyamoto, F.M. 5:00 Women with a Common Genetic Variant in ZnT2 (T288S) Steinberg, H.M. Young, S. Zidenberg-Cherr. Univ. of Have Altered Breast Milk Composition: Implications California, Davis, Sch. of Nursing, Davis Hlth. Syst., for Suboptimal Lactation. S. Lee, C. Dalrymple, S.L. Sacramento, Image Technols. Corp., Salt Lake City, Kelleher. Penn State Hershey Col. of Med. (673.1) USDA, Grand Forks, Univ. of California Agr. and Nat. Resources and Penn State Col. of Nursing. (896.19)

20 SATURDAY NUTRITION

5:00 Observed Differences in Child Picky Eating Behaviors 5:00 Perceptions, Beliefs, and Implementation of the Dietary between the Child’s Home and Center- or Home- Guidelines for Americans Consumer Messages by Based Childcare. V. Luchini, S-Y. Lee, S. Donovan. Low-Income Parents. M. Chea, A.R. Mobley. Univ. of Univ. of Illinois at Urbana-Champaign. (895.13) Connecticut. (896.7) 5:00 Peer-Education about Weight Steadiness (PAWS Club): 5:00 The Effects of Nutrition Education on Fruit and Vegetable Pilot Test of Family Menu Planning Lesson for Parents Consumption in Food Pantry Clients. S. St. Cyr, A. and Their Young Adolescents. C.J. Nikolaus, C.A. Bruzina, M. Linek, M. Butsch-Kovacic, S-Y. Lee. Liguori, A.N. Winslow, S.M. Nickols-Richardson. Univ. of Cincinnati and Cincinnati Children’s Hosp. S Univ. of Illinois at Urbana-Champaign. (896.18) Med. Ctr. (896.17) A 5:00 Adolescents with At-Risk Eating and Lifestyle Behaviors 5:00 Teacher Characteristics Influence Implementation of a T Are Impacted by After-School Schedules across Multi-component, School-Based Nutrition Intervention the Clinical Weight Spectrum. L. Perez, C.K. Miller, in Fourth-Grade Classrooms. J.D. Linnell, M.H. Smith, J.A. Groner. The Ohio State Univ. and Nationwide M. Briggs, K.M. Brian, R.E. Scherr, M. Dharmar, S. Children’s Hosp. (1155.11) Zidenberg-Cherr. Univ. of California, Davis, Placer 5:00 Fluid Intake in Male Brazilian Teens According to and Nevada Counties Coop. Ext., Auburn and Univ. Recommendations for Age, BMI and Physical Activity of California Davis Hlth. Syst., Sacramento. (1155.8) Patterns – The Fitfood Study. R.H.V. Machado, I. 5:00 Comparing Dietary Strategies to Increase Vegetable Iglesia, C. Martinelli, A.C.L. Rocha, C.A. Hartwick, Consumption: Encouraging Tomato Products versus A. Pires, M. Fisberg, L. Moreno. Sabara Children’s Raw Vegetable Consumption. S. Rahman, E. Park, Hosp./José Luiz Egydio Setubal Fndn., São Paulo, K. Reimers, B.M. Burton-Freeman. Illinois Inst. of Univ. of Zaragoza, Spain, Danone Res. and Danone Technol. and ConAgra Foods, Omaha. (895.9) Inst. Intl., Paris and Fed. Univ. of São Paulo. (1155.9) 5:00 MicroRNAs as a Novel Mechanism by Which 5:00 Evaluating the Young Adult Motivation to Prepare Eicosapentaenoic Acid Mediates Inflammation in Healthy Foods Questionnaire Using Exploratory Diet-Induced Obesity. E. Yen, N. Wijayatunga, M. Factor Analysis. A.D. Bailey, D. Miketinas, M. Cater, Pahlavani, L. Ramalingam, K.R. Kottapalli, N.S. B. Zawodniak, G. Tuuri. LSU and LSU AgCtr. (676.11) Kalupahana, P. Gunaratne, K. Rajapakshe, C. 5:00 Participants in the Shaping Healthy Choices Program Coarfa, S. Dharmawardhane, N. Moustaid-Moussa. Increased the Intensity of Physical Activity. D.S. Texas Tech Univ., Univ. of Sri Jayewardenepura and Fetter, R.E. Scherr, J.D. Linnell, M. Dharmar, S.E. Univ. of Peradeniya, Sri Lanka, Univ. of Houston, Schaefer, K.M. Brian, S. Zidenberg-Cherr. Univ. of Baylor Col. of Med. and Univ. of Puerto Rico-Med. California, Davis, Sch. of Nursing, Davis Hlth. Syst., Sci. Campus. (911.7) Sacramento, Agr. and Nat. Resources, Davis and 5:00 Depletion of Dietary MicroRNAs from Cow’s Milk Causes Coop. Ext., Auburn, CA. (895.10) an Increase of Purine Metabolites in Human Body 5:00 Nudges: Fun, Motivational Messages to Encourage and Fluids and Mouse Livers. A.G. Aguilar Lozano, S. Reassure Parents in the Homestyles Randomized Baier, J. Adamec, M. Sadri, D. Giraud, J. Zempleni. Controlled Trial. C. Delaney, J.T. Martin-Biggers, Univ. of Nebraska-Lincoln. (127.1) G. Povis-Alleman, N. Hongu, J. Worobey, C. Byrd- 5:00 Gene, Sex and Diet Interact to Control the Tissue Bredbenner. Rutgers Univ. and Univ. of Arizona. Metabolome. A. Wells, W. Barrington, D. Threadgill, (896.15) S. Dearth, S. Campagna, A. Saxton, B. Voy. Univ. of 5:00 Nutrition Recommendations Critical to Teach Low- Tennessee and Texas A&M Univ. (127.2)

Income Adults in EFNEP: U.S. Dietary Guidelines 5:00 A Genome-Wide Association Study of Plasma α2- Expert Panel Opinion. E. Murray, S. Baker, G. Auld. Macroglobulin Concentrations in Young Adults. J. Colorado State Univ. (896.16) Jamnik, C. Borchers, A. El-Sohemy. Univ. of Toronto 5:00 Validation of Two Brief Questionnaires Designed to and Univ. of Victoria, Canada. (127.3) Assess Fruit and Vegetable Intake among 3rd-5th 5:00 Differential DNA Methylation between Obese and Grade SNAP-Ed Participants. Y. Zhang, G. Hurtado, Normal Weight Women in CD4+ and CD8+ T Cells, M. Reicks. Univ. of Minnesota-Twin Cities. (896.9) and CD16+ Neutrophils. N.M. Hohos, A.K. Smith, V. 5:00 Parent and Adolescent Child Perceptions of a Grocery Kilaru, H.J. Park, D.B. Hausman, L.B. Bailey, R.D. Store Tour: Comparison of Adult- versus Teen-Led Lewis, R.B. Meagher. Univ. of Georgia and Emory Education. C.J. Nikolaus, C.A. Liguori, S.M. Nickols- Univ. (431.1) Richardson. Univ. of Illinois at Urbana-Champaign. 5:00 Effects of Maternal Vitamin D Deficiency on (896.14) Fetal Epigenetic Reprogramming. J. Xue, F.Y. 5:00 Effects of an Educational Group Intervention for Patients Ideraabdullah. Univ. of North Carolina at Chapel Hill. with Type 2 Diabetes on Lifestyle and Glycemic (912.1) Control. L.M. Sterpone, K. Haua-Navarro, A.B. 5:00 Monounsaturated Fatty Acids Impede Inflammation Perez-Lizaur. Univ. Iberoamericana, Mexico City. Partially through Activation of AMPK. C.L. Lyons, O.F. (676.10) Finucane, A.M. Murphy, A.A. Cooke, B. Viollet, P.M. 5:00 Culinary Skills Intervention: Immediate Impacts on Vieira, W. Oldham, B.B. Kahn, H.M. Roche. Conway Knowledge, Attitudes and Self-Efficacy in Adolescent Inst. of Biomolec. and Biomed. Res., Dublin, Inst. Youth. A.R. Oakley, S.M. Nickols-Richardson. Univ. Cochin, INSERM, Paris, Beth Israel Deaconess Med. of Illinois at Urbana-Champaign. (896.6) Ctr., Harvard Med. Sch. and Brigham and Women’s Hosp. (296.5)

21 NUTRITION SATURDAY

5:00 Effect of a Diet Rich in Whole Grains on Gut Microbiota, 5:00 Berberine Ameliorates Hepatic Steatosis and and Immune and Inflammatory Markers of Healthy Suppresses Liver and Adipose Tissue Inflammation Adults. S.M. Vanegas, M. Meydani, J.B. Barnett, in Obesity Mice Independent of AMPK. S-L. Woo, T. A. Kane, B. Goldin, D. Wu, J.P. Karl, C. Brown, P. Guo, X. Guo, H. Li, J. Zheng, R. Botchlett, Y. Cai, Vangay, D. Knights, L. Li, S.S. Jonnalagadda, M. X. Li, Q. Li, X. Xiao, Y. Huo, C. Wu. Texas A&M Univ., Thomas, E. Satlzman, S.N. Meydani. USDA and Sch. Hubei Hosp. of Chinese Med., Wuhan, The First Hosp. of Med., Tufts Univ., Univ. of Minnesota, Minneapolis of CMU, China and Georgia Regents Univ. (126.5) and General Mills, Minneapolis. (296.8) 5:00 Orbitofrontal Cortex Response to Food Portion Size Is 5:00 Vitamin a Supplementation and Lipopolysaccharide- Linked with Obesogenic Appetitive Profile in Children. Induced Inflammation in the Neonate a Pilot Study L.K. English, S.N. Fearnbach, M. Lasschuijt, S.J. in C57BL/6 Mice. C-H. Wei, A.C. Ross. Penn State. Wilson, M. Tanofsky-Kraff, B.J. Rolls, K.L. Keller. (916.2) Penn State, Wageningen Univ., Netherlands and 5:00 Feeding a Maternal Diet Enriched in Docosahexaenoic Uniformed Svcs. Univ. of Hlth. Sci., Bethesda. (270.3) Acid to Lactating Dams Improves the Ex Vivo 5:00 Weight Gain with Metabolic Dysfunction Is Associated Tolerance Response to Egg Protein in Suckled Pups. with Obesity-Related Cancer. S. Chadid, M.R. Singer, C. Richard, E.D. Lewis, S. Goruk, C.J. Field. Univ. of B.E. Kreger, L.L. Moore. Boston Univ. Sch. of Med. Alberta. (296.6) (910.4) 5:00 Effects of a Randomized, Controlled Trial of Daily 5:00 Secretory Factors Produced by Stromal Cultures of Vitamin D3 Supplementation during Pregnancy on Human Omental Adipose Tissue Inhibit Adipose Regulatory Immunity and Inflammation. M. Zerofsky, Differentiation. R.T. Pickering, M-J. Lee, M. Jager, M. B. Jacoby, T.L. Pedersen, C.B. Stephensen. USDA, Layne, S.K. Fried. Boston Univ. Sch. of Med. (126.7) Davis and UC Davis Med. Ctr., Sacramento. (296.7) 5:00 Soy Positively Impacts Cecal Microbiota of 5:00 The Impact of Environmental Enteropathy and Systemic Ovariectomized Rats Selectively Bred for Low Aerobic Inflammation on Infant Growth Failure. C. Naylor, M. Capacity. T-W. Liu, T.M. Zidon, R.J. Welly, Y-M. Park, Lu, J.A. Ma, A.M. Prentice, W.A. Petri. MRC Unit, S.L. Britton, L.G. Koch, J. Padilla, V.J. Vieira-Potter, The Gambia, Univ. of Virginia and London Sch. of K.S. Swanson. Univ. of Illinois, Urbana, Univ. of Hyg. and Trop. Med. (296.4) Missour-Columbiai and Univ. of Michigan. (146.1) 5:00 Dietary Supplementation with Montmorency Tart Cherry 5:00 Relationship between Human Gut Microbiota and Prevents the Alterations in Gut Mucosal Immunity Interleukin 6 Levels in Overweight and Obese Adults. That Occurs with Ovarian Hormone Deficiency. E.K. D. Cooper, E.B. Kim, M. Marco, B. Rust, L. Welch, W. Crockett, J.L. Graef, P. Ouyang, S.L. Clarke, U. Horn, R. Martin, N. Keim. Univ. of California, Davis, DeSilva, E.A. Lucas, B.J. Smith. Oklahoma State USDA, Davis and Seoul Natl. Univ. (146.4) Univ. (916.14) 5:00 Does Milk Portion Size or Energy Density Affect 5:00 Mapping Inflammation and Cancer-Modifying Regions in Preschool Children’s Lunch Intake? S.M.R. Kling, Broccoli Genome. W. Bussler, J. Alley, H. Chandler, L.S. Roe, B.J. Rolls. Penn State. (270.1) C. Thetford, G. Yousef, A. Brown, D. Esposito, 5:00 Comparison of MRI and DXA for Measurement of M.A. Lila, S. Komarnytsky. North Carolina State Visceral Adipose Tissue in Adolescent Females. S.L. Univ., Kannapolis and Raleigh, Iowa State Univ. and Belcher, J.M. Kindler, N.K. Pollock, H.L. Ross, C.M. Catawba Col., NC. (131.8) Modlesky, E.M. Laing, R.D. Lewis. Univ. of Georgia, 5:00 Adherence to the 2015 Dietary Guidelines for Americans Med. Col. of Georgia-Georgia Regents Univ. and and Risk of Healthy and Unhealthy Obesity among Univ. of Delaware. (686.8) Canadian Adults. M. Jessri, W. Lou, M. L’Abbe. Dalla 5:00 Energy Expenditure in Children with Prader-Willi Lana Sch. of Publ. Hlth., Univ. of Toronto. (131.3) Syndrome during Walking. F.A. Chavoya, A. 5:00 Improving the Food Supply by Product Reformulation: Slowetzky-Amaro, D. Castner, A. Hyde, J. Ramirez, Using Nutrient Profiling to Evaluate Foods Consumed A. Wong, V. Layvant, D. Rubin. California State Univ., in the USA. F. Mölenberg, A. Vlassopoulos, G. Fullerton. (687.2) Masset, U. Lehmann. Wageningen Univ., Netherlands 5:00 Gut Microbiota Metabolites in Infancy: Associations and Nestle Res. Ctr., Lausanne. (681.7) with Breastfeeding and Childhood Overweight. S. 5:00 Development of Novel Hollow Zein Nanoparticles for Bridgman, P. Koleva, R. Mandal, M. Azad, C. Field, Delivery of Nutraceuticals. S. Hu, M-L. Fernandez, Y. A. Haqq, A. Becker, S. Turvey, P. Mandhane, P. Luo. Univ. of Connecticut. (680.9) Subbarao, M. Sears, D. Wishart, A. Kozyrskyj. Univ. 5:00 Analysis of Polycyclic Aromatic Hydrocarbons for of Alberta, Univ. of Manitoba, Univ. of British Columbia, Reduction in Simple-Processed Foods According Univ. of Toronto and McMaster Univ., Canada. (146.3) to Manufacturing System. S-J. Kang, S-Y. Yang, 5:00 Effects of an Almond-Enriched Energy Restricted K-W. Lee. Col. of Life Sci. and Biotechnol., Korea Diet on Body Composition, Visceral Adipose Tissue Univ. (680.8) and Blood Pressure in Obese Adults. J. Dhillon, R. 5:00 Are Foods of Higher Nutritional Quality More Expensive Mattes. Purdue Univ. (146.8) Than Their Less Healthy Counterparts? An Analysis 5:00 Differences in Plasma Metabolites in Insulin Resistant of Canadian Packaged Foods. M-E. Labonté, S. and Insulin Sensitive Obese Individuals during a Noorhosseini, J. Bernstein, M. Ahmed, M. L’Abbé. Hyperinsulinemic/Euglycemic Clamp. J.L. Casey, Univ. of Toronto. (131.7) D.W. Van Pelt, C. Burant, J. Horowitz, C. Evans. Univ. of Michigan Sch. of Publ. Hlth. and Sch. of Kinesiol. (889.3)

22 SATURDAY NUTRITION

5:00 Therapeutic Potential of AICAR in Attenuating Obesity- 5:00 Effect of High Folic Acid Diet on Mitochondrial DNA Induced Metabolic, Liver and Kidney Disease. E. Content in Young Adult and Aged Mice. J. Mustra Borgeson, V.W. Borgeson, C. Godson, K. Sharma. Rakic, H. Sawaengsri, C. Reginaldo, J. Selhub, L. Univ. of Gothenburg, Sweden, University Col. Dublin, Paul. USDA and Tufts Univ. (1171.4) Ireland and UCSD. (126.4) 5:00 Iron-Dependent Regulation of Cytoglobin in Neuro 2A 5:00 Network Social Support for Healthy and Obesogenic Cells. J. Fiddler, T. Soh, M. Davis, W. Chowanadisai, Behavior Influences Children’s Dietary Intake and S. Clarke. Oklahoma State Univ. and Midwestern Weight Change during Family-Based Behavioral Univ., AZ. (1173.4) S Obesity Treatment. K.N. Balantekin, J.F. Hayes, R.P. 5:00 1,25-Dihydroxyvitamin D Regulates Energy Substrate A Kolko, R.I. Stein, B.E. Saelens, R.R. Welch, M.G. Metabolism to Reduce Triacylglycerol Accumulation T Perri, K.B. Schechtman, L.H. Epstein, D.E. Wilfley. in 3T3-L1 Adipocytes. B.M. Larrick, K-H. Kim, S.S. Washington Univ. Sch. of Med., Univ. of Pittsburgh, Donkin, D. Teegarden. Purdue Univ. (128.2) Seattle Children’s Hosp., Univ. of Florida and Univ. at 5:00 Characterization of Cystathionine Beta-Synthase and Buffalo. (270.5) Cystathionine Gamma-Lyase in the Production of 5:00 Improved Bioavailability of Iron from Amino Acid Hydrogen Sulfide Biomarkers, Lanthionine and Chelates in Fully Differentiated Human Intestinal Homolanthionine, in a HepG2 Cell Culture Model. Epithelial (Caco-2) Cells. C. Doguer, N. Shay, J.F. B. DeRatt, M. Ralat, J. Gregory. Univ. of Florida. Collins. Univ. of Florida and Oregon State Univ. (1171.5) (918.4) 5:00 Prevalence and Determinants of Suboptimal Vitamin B6 5:00 High Dietary Iron Intake Impairs Growth and Causes Status in Young Adult Women in Metro Vancouver. Copper Deficiency in Sprague-Dawley Rats. J-H. C-l. Ho, T.A.W. Quay, J.L. Black, A.M. Devlin, Y. Ha, C. Doguer, S. Zhao, X. Wang, S.R. Flores, J.F. Lamers. Univ. of British Columbia, Child and Family Collins. Univ. of Florida. (292.4) Res. Inst., Vancouver and Fraser Hlth. Authority, 5:00 Lack of Intestinal Divalent Metal-Ion Transporter 1 Surrey, Canada. (1171.6) Perturbs Copper Homeostasis in Mice. X. Wang, S. 5:00 Zinc and ZIP14 (Slc39a14) Are Required for Adaptation Flores, J-H. Ha, C. Doguer, J.F. Collins. Univ. of to ER Stress in Mouse Liver. M-H. Kim, T.B. Aydemir, Florida. (292.1) R.J. Cousins. Univ. of Florida. (148.2) 5:00 Maternal Choline Supplementation Modulates Maternal 5:00 Dietary Glycine Alters One-Carbon Metabolic Kinetics In and Fetal Choline Metabolism and Downregulates Vivo. Y-H. Huang, E-P.I. Chiang. Natl. Chung Hsing Inflammatory Gene Expression in a Mouse Model of Univ., Taiwan. (272.4) Placental Insufficiency. J.H. King, S.T. Kwan, J. Yan, 5:00 Effect of Vitamin D Fortified Cheese on Oral Glucose X. Jiang, V.G. Fomin, M.S. Roberson, M.A. Caudill. Tolerance in Individuals Exhibiting Marginal Vitamin Cornell Univ. and Brooklyn Col. (272.1) D Status and an Increased Risk for Developing Type 5:00 Lower Hepatic Iron Storage Associated with Obesity in 2 Diabetes: A Double-Blind, Randomized Placebo- Mice Can Be Restored by Decreasing Body Fat Mass Controlled Clinical Trial. T.S. Moreira-Lucas, A.M. through Feeding a Low Fat Diet. H. Chung, D. Wu, D. Duncan, R. Rabasa-Lhoret, R. Vieth, A. Gibbs, A. Smith, S.N. Meydani, S.N. Han. Seoul Natl. Univ. and Badawi, T.M.S. Wolever. Univ. of Toronto, Univ. of USDA at Tufts Univ. (1173.3) Guelph, Canada, Clin. Res. Inst. of Montreal and 5:00 Iron Status and Regulation in High-Risk Pregnant Publ. Hlth. Agcy. of Canada, Toronto. (917.1) African American Women. L. Welke. Univ. of Illinois at 5:00 Hepcidin Attenuates Zinc Efflux in Caco-2 Cells. S.R. Chicago. (292.5) Hennigar, J.P. McClung. U.S. Army Res. Inst. of 5:00 High Iron Diet during Prenatal Alcohol Exposure (PAE) Envrn. Med., Natick, MA. (292.3) May Normalize Iron Homeostasis in PAE Fetuses. 5:00 Novel Role of Glutathione Peroxidase-1 in Liver and A.A. Cheng, S.M. Huebner, S.M. Smith. Univ. of Muscle Protein Metabolism of Mice. L. Tao, Z.P. Zhao, Wisconsin-Madison. (1172.5) X.G. Lei. Cornell Univ. (148.5)

5:00 The AHR Pathway and Its Potential Role in the 5:00 Vitamin B12 and Placental Expression of Transcobalamin Regulation of the 15 kDa Selenoprotein. S.E. in Pregnant Adolescents. A.J. Layden, K.O. O’Brien, Galinn, L.E. Rosso, B.A. Carlson, R. Tobe, S. E.K. Pressman, T.R. Kent, J.L. Finkelstein. Cornell Naranjo-Suarez, P.A. Tsuji. Towson Univ., NCI, NIH, Univ., Univ. of Rochester Med. Ctr. and St. John’s Ritsumeikan Univ., Japan and Johns Hopkins Univ. Res. Inst., Bangalore. (272.3) (1170.5) 5:00 Zinc-Induced Upregulation of Metallothionein-2A Is Predicted by Gene Expression of Zinc Transporters in Healthy Adults. A. Chu, M. Foster, S. Ward, K. Zaman, D. Hancock, P. Petocz, S. Samman. Univ. of Otago, New Zealand, Univ. of Sydney and Macqurie Univ., Australia. (148.1)

23 PATHOLOGY SATURDAY Pathology

48. MOLECULAR AND CELLULAR BASIS OF 50. EMERGING TRANSLATIONAL PATHWAYS IN DISEASE: FROM PREVENTION TO CANCER PULMONARY PATHOLOGY METASTASIS: THE BIOLOGY AND THERAPY OF BREAST CANCER METASTASIS Minisymposium

Sat. 8:30 am—San Diego Convention Center, Room 4 Symposium Chaired: S.H. Phan (Supported by unrestricted educational grants from Elsevier and Friends for an Earlier Breast Cancer Test) Pulmonary Pathobiology (Sponsored by: the ASIP Breast Cancer and Tumor 8:30 Current Overview of Pulmonary Fibrosis. Microenvironment & Metastasis Scientific Interest Groups) 8:45 50.1 Neutrophil Extracellular Traps Drive Bleomycin- Induced Lung Fibrosis by Regulating TGFβ1-Dependent Sat. 8:30 am—San Diego Convention Center, Room 2 Interactions of Platelets and Macrophages. D.R. Riehl, J. Chaired: B. Felding Roewe, S. Klebow, N.L. Esmon, S. Eming, G. Colucci, K. Schäfer, M. Gunzer, A. Waisman, P.A. Ward, C.T. Esmon, M. Cochaired: W.B. Coleman Bosmann. Univ. Med. Ctr. Mainz, Oklahoma Med. Res. Fndn., Univ. of Cologne, Clin. Luganese Moncucco, Switzerland, Univ. Cancer Biology Duisburg-Essen, Germany and Univ. of Michigan Med. Sch. Breast Cancer 9:00 50.2 Dimethyl Fumarate Ameliorates Pulmonary Hypertension In Vivo and Prevents Fibrosis via βTRCP-Mediated Neoplasia Degradation of β-Catenin and TAZ. A. Grzegorzewska, R. Han, 8:30 Targeting the Tumor Microenvironment in Breast Cancer. F. Seta, L. Stawski, C. Feghali-Bostwick, J. Browning, M. D. Panigrahy. Beth Israel Deaconess Med. Ctr. Trojanowska. Boston Univ. and Med. Univ. of South Carolina. 9:15 Breast Cancer Brain Metastasis: Molecular Subtypes 9:15 50.3 Allergen-Induced Endoplasmic Reticulum and Prognosis. S. Wei. Univ. of Alabama at Stress Regulates Lung Inflammation and Fibrosis. S. Jalahalli Birmingham Sch. of Med. Mariswamy, E.M. Nakada, B. Mihavics, S. Hoffman, D. 10:00 Metabolism in Breast Cancer Brain Metastasis. S. Chapman, C.G. Irvin, A. Dixon, M. Poynter, V. Anathy. Univ. Kesari. UCSD. of Vermont. 10:45 Mechanisms of Breast Cancer Metastasis and 9:30 50.4 Organic Cation Transporter Novel Type-1 and Opportunities for Intervention. B. Felding. The Pulmonary Responses to Secondhand Smoke. D.C. Scripps Res. Inst. Milner, J.B. Lewis, D.R. Winden, J. Gassman, T. Monson, D. Broberg, J.A. Arroyo, P.R. Reynolds. Brigham Young Univ. 49. PATHOBIOLOGY FOR BASIC SCIENTISTS: and Roseman Univ. of Hlth. Sci. METABOLISM RUN AMOK: UNDERSTANDING 9:45 50.5 Knockdown Glucose-6-Phosphate BIOCHEMICAL PATHWAYS AND THEIR Dehydrogenase Promotes EMT through Downregulation of E-Cadherin by miR-200b Inhibition in A549 Cells. Y-H. Wu, Y-H. PATHOLOGIC CONSEQUENCES IN CANCER Lee, D.T-Y. Chiu. Chang Gung Univ. and Chang Gung Mem. AND SYSTEMS BIOLOGY Hosp., Taiwan. 10:00 50.6 Amphiregulin Promotes Fibroblast Activation Course in Pulmonary Fibrosis. T. Liu, F. Gonzalez De Los Santos, L. (Sponsored by: the ASIP Education Committee ) Ding, Z. Wu, S.H. Phan. Univ. of Michigan. 10:15 50.7 R-Spondin2 Is Upregulated in Idiopathic Sat. 8:30 am—San Diego Convention Center, Room 3 Pulmonary Fibrosis and Affects Fibroblasts Behavior. A.

Chaired: W. Mars Munguia, C. Becerril, C. Mendoza, Y. Balderas, R. Ramirez, J. Melendez, A. Pardo, M. Selman. Biol. Sci., Natl. Inst. of Cochaired: R.N. Mitchell Resp. Dis., Fac. of Sci. and Natl. Inst. of Genomic Med., UNAM, Mexico City. Cancer Biology 10:30 50.8 TMPRSS4: A Novel Serine Protease Involved Metabolism and Metabolic Disease in IPF Development? A.M. Valero, J. Cisneros, R. Ramírez, M. Gaxiola, C. Becerril, A. Pardo, M. Selman. Fac. of Sci, Natl. Microbiome Autonomous Univ. of Mexico and INER, Mexico City. 8:30 Tumor Metabolic Pathways; Warburg Effect 10:45 50.9 Advancement in the Diagnosis and Treatment (Glioblastoma as a Model). P. Mischel. UCSD Sch. of Granulomatous/Lymphocytic Interstitial Lung Disease. B.R. of Med. Hoffmann, A. Vallejos, A.S. Greene, J.M. Routes. Med. Col. 9:30 How the Microbiome Influences Human Metabolism. G. of Wisconsin and Children’s Hosp. of Wisconsin. Siuzdak. The Scripps Res. Inst. 11:00 50.10 Absence of Mast Cells in an Experimental 10:30 Obesity, Metabolic Syndrome, and Non-alcoholic Model of Pulmonary and Cardiac Fibrosis, the CUX-1 Mice. Steatohepatitis. D. Cohen. Harvard Med.Sch. N.A. Reddy, F. Raza, A. Said, S. Livingston, D. Jacobsen, D. Kearns, R. Baybutt, G. Van Den Heuvel, A. Molteni, S. Hamidpour. Univ. of Missouri Kansas City, Wheaton Col., IL and Western Michigan Univ.

24 SATURDAY PATHOLOGY

51. IMAGING PATHOLOGY: HOW TO CATCH LIGHT 52. XVITH ANNUAL WORKSHOP ON GRADUATE IN A BOTTLE EDUCATION IN PATHOLOGY: INTEGRATING CLINICAL AND ANATOMIC PATHOLOGY Minisymposium Workshop Sat. 8:30 am—San Diego Convention Center, Room 5A (Sponsored by: the ASIP Education Committee and the Chaired: R. Levenson Association of Pathology Chairs ) S Cochaired: D. Kaufman A Sat. 11:45 am—San Diego Marriott Marquis & Marina Hotel, Digital and Computational Pathology Temecula T Imaging, Immunohistochemistry and Microscopy Chaired: D. Karcher

8:30 Introduction. Cochaired: M. Willis 8:35 51.1 Assessment of Autofluorescent Signatures Education in Multiple Tissue Types with Novel Excitation-Scanning Hyperspectral Imaging. P.F. Favreau, J.A. Deal, D.A. Weber, Pathobiology Education T.C. Rich, S.J. Leavesley. Univ. of South Alabama. 8:50 51.2 Potential of Hyperspectral Imaging for Label- 11:45 Introduction. D. Karcher. The George Washington Univ. Free Tissue and Pathology Classification. J.A. Deal, P. Favreau, 11:50 The Graduate Program at UCSD. S. Gonias. UCSD D. Weber, T. Rich, S. Leavesley. Univ. of South Alabama. 12:00 The Graduate Program at the University of Pittsburgh. 9:05 51.3 MUSE: A New, Fast, Simple Microscopy G.K. Michalopoulos. Univ. of Pittsburgh Method for Slide-Free Histology and Surface Topography. 12:10 The Graduate Program at UNC. J. Homeister. Univ. of R.M. Levenson, F. Fereidouni. Univ. of California Davis Med. North Carolina at Chapel Hill Ctr., Sacramento. 12:30 Discussion. 9:20 51.4 Lymphocyte Response Assay: Report on Precision of Novel Cell Culture Test. A.E. Lynch, R. Jaffe. Hlth. 53. HIGHLIGHTS: GRADUATE STUDENT Studies Collegium, Ashburn, VA. RESEARCH IN PATHOLOGY 9:35 51.5 Monitoring Cell Death in Real-Time/Time- Lapse Studies. R. Edward. BioStatus Ltd., Shepshed, U.K. Poster Discussion 9:50 51.6 How Different Are We? Performing Formalin (Sponsored by: ASIP Committee for Career Development Fixed Paraffin Embedded Tissue Immunohistochemistry and Diversity) across Species. K.N. Gibson-Corley, G. Ofori-Amanfo, M.R. Leidinger, A.M. Lambertz. Univ. of Iowa. Sat. 1:30 pm—San Diego Convention Center, Room 3 10:05 51.7 FLIM-FRET Imaging of Ligand-Receptor Chaired: T.A. Reaves Binding in Tumor Cells In Vitro and In Vivo. M.M. Barroso, A. Rudkouskaya, S. Patel, N. Sinsuebphon, X. Intes. Albany Cochaired: B. Woolbright Med. Col. and Rensselaer Polytech Inst. 10:20 51.8 Digital Determination of Chemotherapeutic 1:30 Welcome and Introduction. Drug-Induced Damage Sites in Single DNA Molecules Using 1:35 Oral Presentations Nanofluidic Channels. D.G. Kaufman, P.D. Chastain, S.A. Soper. Univ. of North Carolina at Chapel Hill and William Carey 1:45 Microvascular Endothelial Cells Can Exhibit Autophagy Univ. Col. of Osteo. Med., MS. In Vivo: Role in Neutrophil Transendothelial Cell 10:35 51.9 Deterministic and Genetic Migration? C.M. Pickworth, R. Beal, N. Reglero, L. Manipulation of Organotypic Brain Slice Cultures for Ex Vivo Lintermans, B. Colom, M-B. Voisin, M. Golding, S. Imaging. P.E. Gygli, S. Byers, N. Higuita-Castro, C. Czeisler, Nourshargh. Barts and The London Sch. of Med. and D. Gallego-Perez, J.J. Otero. The Ohio State Univ. and Dent., Queen Mary Univ. of London. (165.8) Kenyon Col., OH. 1:55 Role of Sumoylation in Aldehyde Dehydrogenase 2 10:50 Discussion. Function during Alcoholic Liver Disease. C. Cossu, K. Ramani, Y. Spissu, A. Floris, M.L. Tomasi. Cedars- Sinai Med. Ctr., Univ. of Sassari and Univ. of Cagliari, Italy. (516.10) 2:05 Activation of TRPVv1 by 12(S)-HpETE and 20-HETE Releases CGRP and Protects the Heart against the Visit the Exhibits Cardiac Dysfunction Caused by LPS. J. Chen, A.J.P. Hamers, M. Finsterbusch, C. Thiemermann, A. April 3–April 5 Ahluwalia. Barts and The London Sch. of Med. and Dent., Queen Mary Univ. of London. (306.4) Exhibit Hours Sunday–Tuesday 9:00 AM–4:00 PM

25 PATHOLOGY SATURDAY

2:05 Poster Presentations P5 Cathepsin Localization and Activity on the Intestinal P2 Foxi3: A Sly Regulator of Bone Development, Promotes Epithelial Barrier of Rats following Hemorrhagic Prostate Cancer. A. Mukherjee. Troy Univ. (698.20) Shock and Reperfusion. A.S. Courelli, F. DeLano, P4 Mechanisms Underlying the Induction of a Profibrotic G.W. Schmid-Schonbein. UCSD. (920.2) Epithelial Phenotype during Renal Fibrosis. J. Folke P7 Role of Cox Pathway in Human Monocytes and Bialik, M. Rozycki, P. Speight, Z.M. Miranda, S.G. Monocyte-Derived Dendritic Cells Infected by Szeto, D.A. Yuen, Q. Dan, K. Szászi, S.F. Pedersen, Trypanosoma cruzi. S.C.H. Lonien, R.C. de Freitas, A. Kapus. St. Michael’s Hosp., Toronto, Univ. of H.T. Suzukawa, F.F. dos Santos, M.I. Lovo-Martins, Copenhagen and Univ. of Toronto. (445.6) G.F. Silveira, P.F. Wowk, J. Bordignon, P. Pinge- P6 Inflammation as a Contributor to Ingestive and Vocal Filho. State Univ. of Londrina and Oswaldo Cruz Dysfunction in a PINK1 Knockout Rat Model of Fndn., Curitiba, Brazil. (925.20) + Parkinson Disease. K.M. Yang, H.N. Mulholland, M.P. P9 FoxP3 T-Cells and PD-L1 Highlight Immune- Kurup, M.R. Ciucci. Univ. of Wisconsin-Madison. Suppressive Profiles in Vulvar Squamous Cell (1179.2) Carcinoma. E.R. Holthoff, T. Kelly, C.M. Quick, S.R. P8 A Novel Bioinspired Microfluidic Assay for Investigation Post. Univ. of Arkansas for Med. Sci. (439.10) of the Role of Protein Kinase C-Delta in Human P11 Pharmacological Inhibition of p38/MAPK Improves Neutrophil-Endothelium Interaction during Acute Cardiac Function in Cardiac-Specific Bag3-P209L Inflammation. F. Soroush, Y. Tang, P. Pandian, Transgenic Mice. S.C. Eaton, S. Takayama, T.N. L.E. Kilpatrick, M.F. Kiani. Temple Univ. and CFD Sidorova, K.T. Murray, M.S. Willis. Univ. of North Research Corp., Huntsville, AL. (1177.3) Carolina at Chapel Hill, Boston Univ. and Vanderbilt P10 Cell-Type Specific Mechanisms Regulate Rhythmic Univ. (306.5) Leukocyte Migration to Tissues. W. He, K. Kraus, 3:50 ASIP Young Scientist Leadership Award Lecture: D. Druzd, A. de Juan, L. Ince, C-S. Chen, C. Approaching Amyotrophic Lateral Sclerosis from Scheiermann. Ludwig Maximilians Univ., Munich. Cellular, System and Technological Angles. C. (165.11) Kolarcik. Univ. of Pittsburgh. P12 OxLDL Exerts a Biphasic Effect on Endothelial 3:50 Concluding Remarks. Function: A Role for Oxidised Lipids in Angiogenesis and Inflammation. M. Olding, M.R. Ardern-Jones, E. 54. ASIP YOUNG SCIENTIST LEADERSHIP Healy, T.M. Millar. Univ. of Southampton. (165.9) AWARD LECTURE

2:55 Oral Presentations Award Lecture 3:05 CD36-Myeloperoxidase Connection and the Activation Sat. 3:35 pm—San Diego Convention Center, Room 3 of Intestinal Fibroblasts. M. Anderson-Thomas, A. Nillas, T.A. Reaves. Med. Univ. of South Carolina. Neurobiology (922.1) 3:05 Intercellular Adhesion Molecule 1 Regulates Left Neuropathology Ventricular Leukocyte Recruitment, Cardiac 3:35 ASIP Young Scientist Leadership Award Lecture: Remodeling and Function in Pressure Overload- Approaching Amyotrophic Lateral Sclerosis from Induced Heart Failure. A.M. Salvador, T. Nevers, M. Cellular, System and Technological Angles. C. Aronovitz, B. Wang, I. Jaffe, R. Blanton, P. Alcaide. Kolarcik. Univ. of Pittsburgh. Tufts Med. Ctr. (306.6) 3:05 Influence of PI3K and MAPK Pathway Mutations on 55. MOLECULAR AND CELLULAR BASIS Response to Mono and Dual Treatment with Targeted OF DISEASE: FROM PREVENTION TO Kinase Inhibitors. R.S. McNeill, D.A. Canoutas, R.E. Bash, R.S. Schmid, B.H. Constance, G.L. Johnson, CANCER METASTASIS C.R. Miller. Univ. of North Carolina at Chapel Hill. Symposium (515.1) (Sponsored by: the ASIP Tumor Microenvironment & 3:05 Poster Presentations Metastasis Scientific Interest Group ) P1 Expression Analysis of Arpin, a Novel Arp2/3 Inhibitor, in Endothelial and Epithelial Cells under Basal and Sat. 2:00 pm—San Diego Convention Center, Room 2 Inflammatory Conditions. S.D. Chanez Paredes, Chaired: P. Dasqupta J. Garcia Cordero, H. Vargas Robles, L. Cedillo Barron, M. Schnoor. CINVESTAV, Mexico City. Cochaired: A. Maitra (1180.2) Cancer Biology P3 Nicotine Promotes Cholangiocarcinoma Growth in Xenograft Mice. A. O’Brien, C. Hall, L. Ehrlich, T. Breast Cancer White, T. Lairmore, D.E. Dostal, S. Glaser. Texas Tumor Microenvironment and Metastasis A&M Hlth. Sci. Ctr., Baylor Scott & White Healthcare and Central Texas Veterans Hlth. Care Syst., Temple. 2:00 Introduction. M.E. Sobel. ASIP. (56.5) 2:05 ASIP Gold-Headed Cane Award Lecture: Biology and Therapy of Cancer Metastasis. I. Fidler. Univ. of Texas MD Anderson Cancer Ctr.

26 SATURDAY PATHOLOGY

3:00 Origin and Evolution of Metastatic Traits in Breast 4:15 56.10 Dysregulation of miRNA Regulatory Networks Cancer. Y. Kang. Princeton Univ. by Chronic Ethanol Consumption Impairs Liver Regeneration. 3:45 Getting across the Endothelial Gate: Mechanisms A. Parrish, E. Juskeviciute, J.B. Hoek, R. Vadigepalli. and Opportunities to Prevent Metastasis. L. Iruela- Thomas Jefferson Univ. Arispe. UCLA. 4:30 56.11 Cell-Specific Wnts Regulate Liver Zonation and Regeneration. M. Preziosi, J. Yang, H. Okabe, C. Diegel, B. Williams, S. Monga. Univ. of Pittsburgh and Van Andel Inst., 56. CELL-MOLECULE CIRCUITRY OF LIVER S INJURY AND REGENERATION Grand Rapids, MI. 4:45 56.12 Deletion of Estrogen Receptor Alpha in Rats A Minisymposium Speeds Up Liver Regeneration after CCl4-Induced Liver Injury. T S. McGreal, M.A.K. Rumi, M. Soares, U. Apte. Univ. of Kansas 2:00 pm—San Diego Convention Center, Room 4 Med. Ctr.

Chaired: K. Nejak-Bowen 57. TISSUE INFLAMMATION AND Cochaired: H. Francis LEUKOCYTE TRAFFICKING Liver Pathobiology Minisymposium Regenerative Medicine (Stem Cells, Tissue Regeneration, Biomaterials) Sat. 2:00 pm—San Diego Convention Center, Room 5A 2:00 56.1 Hepatic Stellate Cells Play an Essential Role in Chaired: D. McCay Acetaminophen-Induced Hepatocyte Injury with or without Prior Cochaired: R. Jones Endotoxemia. R. Rani, A. Tandon, S. Kumar, C.R. Gandhi. Univ. of Cincinnati and Cincinnati Children’s Hosp. Med. Ctr. Inflammation/Immunity 2:15 56.2 Cross-Talk among Kupffer Cells and Hepatic Inflammation Stellate Cells Is Critical for Kupffer Cell Activation during Liver Injury. K. Roth, B. Copple, R. Albee. Michigan State Univ. Vascular Biology 2:30 56.3 Epigenetic Silencing of MicroRNA-34a in 2:00 57.1 Extracts of the Tapeworm, Hymenolepis Human Cholangiocarcinoma Cells via DNA Methylation and diminuta, Recruit CCR2+PDL1+ Myeloid Cells with the Capacity EZH2: Impact on Regulation of Notch Pathway. H. Kwon, to Inhibit Dextran Sodium Sulphate-Induced Colitis. F. Lopes, K. Song, C. Han, J. Zhang, N. Ungerleider, L. Yao, T. Wu. J.L. Reyes, G. Leung, N. Mancini, A. Wang, D. McKay. Univ. Tulane Univ. of Calgary, Canada. 2:45 56.4 A Balancing Act: Role of HNF4α and β-Catenin 2:15 57.2 Microbiota-Derived Tryptophan Metabolites in Hepatobiliary Development and Cholangiocarcinoma Activate Aryl Hydrocarbon Receptor and Induce IL-10 Pathogenesis. C. Walesky, W. Goessling. Harvard Med. Sch., Receptor Expression in Intestinal Epithelia. E.E. Alexeev, J.M. Brigham and Women’s Hosp. Lanis, K.D. Schwisow, D.J. Kominsky, S.P. Colgan. Univ. of 3:00 56.5 Nicotine Promotes Cholangiocarcinoma Colorado Anschutz Med. Campus and Montana State Univ. Growth in Xenograft Mice. A. O’Brien, C. Hall, L. Ehrlich, T. 2:30 57.3 Cell Differentiation in the Murine Intestine White, T. Lairmore, D.E. Dostal, S. Glaser. Texas A&M Hlth. Requires NADPH Oxidase 1. T. Darby, R. Jones. Emory Univ. Sci. Ctr., Baylor Scott & White Healthcare and Central Texas 2:45 57.4 Hypoxia-Regulated Autophagic Pathways Veterans Hlth. Care Syst., Temple. Mediate Epithelial Defense during Mucosal Inflammation. D. 3:15 56.6 Stem Cell-Based Biliary Organoids and Kitzenberg, B. Saeedi, C. Kelly, K. Schwisow, E. Campbell, Gallbladder-Like Structures for Disease Modeling of Primary J. Lanis, V. Curtis, L. Glover. Univ. of Colorado AMC, Aurora Sclerosing Cholangitis and Alagille Syndrome. D. Contreras, and Emory Univ. Sch. of Med. J. Ignatius Irudayam, A.W. Annamalai, A. Klein, S.W. 3:00 57.5 Markers of Hypoxia and Correlation with French, V. Arumugaswami. Bd. of Governors Regen. Med., Disease Severity in Inflammatory Bowel Disease. K.D. Inst., Cedars Sinai Med. Ctr. and UCLA. Schwisow, S. Colson, M. Gerich, M. Lovell, A. Allshouse, A. 3:30 56.7 The Secretin Receptor Antagonist (SCT 5-27) Yeckes, B. Kessler, S. Keely, E. Hoffenberg, E. de Zoeten, S. Reduces Biliary Hyperplasia and Liver Fibrosis in an Animal Colgan. Univ. of Colorado, Children’s Hosp. Colorado, Univ. of Model of Primary Sclerosing Cholangitis. S. Glaser, F. Meng, Colorado Hosp. and Colorado Sch. of Publ. Hlth., Aurora. N. Wu, J. Venter, K. Kyritsi, G. Alpini. Texas A&M Hlth. Sci. 3:15 57.6 Entamoeba histolytica Stimulates the Ctr., Central Texas Veterans Hlth. Care Syst. and Baylor Scott Release of the Alarmin Molecule HMGB1 upon Contact with & White Healthcare. Macrophages. S. Begum, J. St-Pierre, F. Moreau, K. Chadee. 3:45 56.8 Cholangiocyte Regeneration and Liver Repair Univ. of Calgary, Canada. Are Impaired in HDC-/- Mice following 70% Partial Hepatectomy 3:30 57.7 Endotoxin-Stimulated Hepatic Stellate Cells via Dysregulated Notch Signaling. H. Francis, L. Hargrove, F. Increase Suppressive Potential of Regulatory T Cells via IDO- Meng, L. Kennedy, S. DeMorrow, G. Alpini. Central Texas Mediated AhR Activation: Therapeutic Implications. S. Kumar, Veterans Hlth. Care Syst., Baylor Scott & White Hlth. and A. Dangi, C.R. Gandhi. Univ. of Cincinnati and Cincinnati Texas A&M Hlth. Sci. Ctr., Temple. Children’s Hosp. Med. Ctr. 4:00 56.9 Epidermal Growth Factor Receptor Signaling: 3:45 57.8 Differential Regulation of Macrophage Glucose A Double-Edged Sword in Acetaminophen-Induced Liver Injury Metabolism by M-CSF and GM-CSF: Implications for 18F-FDG and Regeneration. B. Bhushan, P. Borude, M.W. Manley, H. PET Imaging of Inflammation. S. Tavakoli, J.D. Short, K. Chavan, Y. Xie, K. Du, M. McGill, M. Lebofsky, H. Jaeschke, Downs, N. Huynh Nga, R. Asmis. Univ. of Texas Hlth. Sci. Ctr. P. Kasturi, U. Apte. Univ. of Kansas Med. Ctr. at San Antonio.

27 PATHOLOGY/PHARMACOLOGY SATURDAY

4:00 57.9 CD43 Contributes to Mouse Th17 Cell 59. ASIP OUTSTANDING INVESTIGATOR Adhesion to Intercellular Adhesion Molecule-1. F.E. Velazquez, AWARD LECTURE A. Salvador, T. Nevers, P. Alcaide. Tufts Sackler Grad. Sch. and Tufts Med. Ctr. Award Lecture 4:15 57.10 FPR1 and Activation of Intestinal Fibroblasts. T.A. Reaves, M. Anderson-Thomas, A. Nillas, M. Lecher. Sat. 5:00 pm—San Diego Convention Center, Room 2 Med. Univ. of South Carolina and Col. of Charleston. Cancer Biology

58. ASIP TRAINEE AND STUDENT Neoplasia WELCOME RECEPTION 5:00 ASIP Outstanding Investigator Award Lecture: Making Progress against Pancreatic Cancer: Where the Special Session Rubber Hits the Road. A. Maitra. MD Anderson Cancer Ctr. Sat. 4:00 pm—San Diego Convention Center, Foyer outside Rooms 1–5 Pharmacology

60. SECURING NIH INTRAMURAL 61. TEACHING INSTITUTE: DEVELOPING MENTEES FELLOWSHIPS TO ENHANCE YOUR USING IDPS PHARMACOLOGY TRAINING Symposium Symposium (Sponsored by: The Division for Pharmacology Education) (Sponsored by: The Division for Pharmacology Education) Sat. 12:00 pm—San Diego Convention Center, Room 15B (Cosponsored by: all Divisons) Cochaired: K. Karpa and J.P. Neiswinger Sat. 9:30 am—San Diego Convention Center, Room 15A Pharmacology Education Cochaired: J. Clark and A. Reid Education Pharmacology Education Career Development Education 12:00 The What and Whys of IDPs for NIH-Supported Career Development Trainees. N. Desmond. NIMH, NIH. 12:30 Using Available Tools to Facilitate IDP Development. C. 9:30 Introduction. Fuhrmann. Univ. of Massachusetts Med. Sch. 9:35 Fellowship Opportunities at the NIH. A. Reid. NIMH, NIH. 1:00 The Reality of IDP Implementation. P. S. Clifford. Univ. 10:00 NIMH: Opportunities for the Investigation and Treatment of Illinois at Chicago. of Mental Illnesses Through Basic and Clinical 1:30 How an IDP Jump-Started My Career. A. Research. J. Clark. NIMH, NIH. Klementowicz. UCSF. 10:25 NIAID’s Global Health Research Challenge: Emerging, 2:00 Panel Discussion. Persisting and Preventing Infectious Diseases. W. Fibison. NIAID, NIH. 10:50 An Overview of the NINDS Intramural Research 62. GRADUATE STUDENT - Program from Basic to Clinical Neurosciences. K. POSTDOCTORAL COLLOQUIUM Roche. NINDS, NIH. 11:15 NIDCD Research Training in the Hearing and Colloquium Communication Sciences. E. Monzack. NIDCD, NIH. (Sponsored by: The ASPET Mentoring and Career 11:40 Panel Discussion. Development Committee )

Sat. 2:45 pm—San Diego Marriott Marquis & Marina Hotel, San Diego Ballroom B Are You Tweeting about Chaired: L. Wecker EB 2016? Career Development Education To Tweet use #expbio 2:45 Mentoring Your Mentor: Key Skills for Effective Mentoring Relationships with Shared Responsibility. R. McGee. Northwestern Univ. Feinberg Sch. of Med. Be sure to follow EB on Facebook and Twitter.

28 SATURDAY PHARMACOLOGY/PHYSIOLOGY

63. ASPET BUSINESS MEETING AND 64. ASPET-PHRMA FOUNDATION OPENING AND AWARDS PRESENTATION AWARDS RECEPTION

Business Meeting Special Event

Sat. 6:00 pm—San Diego Convention Center, Room 16AB Sat. 7:30 pm—San Diego Convention Center, East Mezzanine and Terrace Hear updates on Society activities and initiatives. Join us S in recognizing excellence in pharmacology as we present the The opening reception immediately follows the conclusion ASPET 2016 Scientific Achievement Awards, Travel Awards, and of the business meeting. ASPET members and pharmacology A PhRMA Foundation Awards. attendees are welcome to join us as we celebrate our awardees T and the 50th Anniversary of the PhRMA Foundation.

Physiology

65. KEEP YOUR EYE ON THE ION. REFRESHER 67. MICROCIRCULATION: PRESIDENT’S COURSE ON IONIC HOMEOSTASIS AND SYMPOSIUM: BLOOD CELL- SYSTEMS PHYSIOLOGY MICROVESSEL INTERACTIONS

Symposium Symposium (Sponsored by: APS Education Committee) (Sponsored by: The Microcirculatory Society)

Sat. 8:00 am—San Diego Convention Center, Room 24 Sat. 9:30 am—San Diego Convention Center, Room 23

Chaired: D.W. Rodenbaugh and K. Scrogin Chaired: R.E. Rumbaut

Ion Transport 9:30 Chair’s introduction. R. Rumbaut. Baylor Col. of Med. 9:35 CD47 and Its Expanding Role in Innate and Adaptive Education Immune Responses. F. Lucinskas. Brigham and Hypertension Women’s Hosp., Harvard Med. Sch. 10:00 Integrin Activation in Rolling Neutrophils. K. Ley. La 8:00 Regulation of Sodium Homeostasis and Hypertension. Jolla Inst. for Allergy and Immunol. J. Osborn. Univ. of Minnesota, Minneapolis. 10:25 Contributions of Microvascular Inflammation to Wound 9:00 Regulation of Potassium Homeostasis and Renal Healing. A.R. Burns. Univ. of Houston. Disease. B. Palmer. Univ. of Texas Southwestern 10:50 In Vivo Imaging of Infection-Induced Cogulopathy in Med. Ctr. the Microcirculation. C.N. Jenne, R.P. Davis, B. 10:00 Acid Base Disturbances and Regulation of Potassium. McDonald. Univ. of Calgary, Canada and Univ. of L. Hamm. Tulane Univ. Sch. of Med. British Columbia. (722.11) 11:00 Cardiac Ischemia: Ionic Currents and the ECG. R. 11:10 Reduced Endothelial Basal Nitric Oxide Induces Klabunde. Marian Univ. Col. of Osteo. Med. Leukocyte Adhesion through Src-Dependent Phosphorylation of Constitutive Intercellular Adhesion 66. PRE-EB MEETING OF THE EPITHELIAL Molecule-1. B. Lucke-Wold, A. Logsdon, X. Li, S. TRANSPORT GROUP AND YOUNG Xu, X. Lichong, C. Siedlecki, J. Huber, C. Rosen, P. INVESTIGATORS SYMPOSIUM He. West Virginia Univ. Sch. of Med. and Penn State Col. of Med. (723.11) Special Session (Sponsored by: APS Epithelial Transport Group) 68. THIRD ANNUAL APS PHYSIOLOGICAL GENOMICS GROUP CONFERENCE Sat. 9:00 am—San Diego Convention Center, Room 28A

Chaired: M. Levi Special Session (Sponsored by: APS Physiological Genomics Group)

Sat. 1:00 pm—San Diego Convention Center, Room 25A

29 PHYSIOLOGY SATURDAY

69. ADVANCED MICROSCOPY TECHNIQUES FOR 72. WATER AND ELECTROLYTE HOMEOSTASIS THE STUDY OF PHYSIOLOGY SECTION TRAINEE AWARD FINALISTS SESSION AND DATA DIURESIS Workshop Award Session Sat. 1:00 pm—San Diego Convention Center, Room 26 Supported by Data Sciences International and Juan Chaired: G.R. Kolar and G. Yosten Carlos Romero Fund 1:00 Practical Application of Super Resolution Microscopy. P. (Sponsored by: APS Water and Electrolyte Pellett. GE Healthcare. Homeostasis Section) 1:40 Correlative Light and Electron Microscopy. E. Wright. Emory Univ. Sat. 2:15 pm—San Diego Convention Center, Room 24 2:20 Confocal Intravital Microscopy. S. Nourshargh. William Chaired: D. Ho, J. Reckelhoff and P. O’Connor Harvey Res. Inst.

70. HAVING TROUBLE WITH YOUR IACUC? Trainee Awards Finalists Competition Chaired: Dao Ho and Jane Reckelhoff. Symposium (Sponsored by: APS Animal Care and Predoctoral Award Finalist Presentations Experimentation Committee) 2:15 Chronic Flutamide Treatment Alters Intrarenal Renin Sat. 1:00 pm—San Diego Convention Center, Room 25B Angiotensin System Expression in Intrauterine Growth Restricted Female Rats. J.H. Dasinger, S. Chaired: J. Henegar Intapad, B.R. Rudsenske, B.T. Alexander. Univ. of Science Policy Mississippi Med. Ctr. (1214.5) 2:30 Flow-Induced Activation of NO Production Is Calcium- 1:00 What All PIs Should Know About their IACUC. J.R. and HDAC1-Dependent in Inner Medullary Collecting Henegar. Univ. of Missouri. Duct Cells. R.S. Sedaka, K.A. Hyndman, J.S. 1:30 Balancing Institutional Risk and Compliance. J. Pollock. Univ. of Alabama at Birmingham. (964.17) Haywood. Michigan State Univ. 2:45 A high Fat Diet Increases Blood Pressure and Leads 2:00 How Offensive Is the Offense? And Other IACUC to a Renal Proinflammatory Immune Cell Profile in Debates. A. Comuzzie. Texas Biomed. Res. Inst. Female Dahl Salt-Sensitive Rats. L. Taylor, J. Musall, 2:30 Ideas for Improving Animal Research Regulaotory B. Baban, E.J. Belin de Chantemele, J. Sullivan. Burden. B. Hansen. Univ. of South Florida. Georgia Regents Univ. (964.5)

71. MICROCIRCULATION: SIGNAL INTEGRATION Postdoctoral Award Finalists Presentations AND MICROCIRCULATORY BLOOD FLOW (Sponsored by: Juan Carlos Romero Fund) CONTROL: MAKING PARTS WHOLE USING A 3:00 Estradiol Facilitates a More Rapid Natriuretic Response NETWORK APPROACH to a High Salt Diet in Female Rats. E.Y. Gohar, D.M. Pollock. Univ. of Alabama at Birmingham. (1216.8) Symposium 3:15 RhoBTB1, a Novel PPARγ Target Gene Regulates Vascular Function. M. Mukohda, S-R.C. Ibeawuchi, (Sponsored by: The Microcirculatory Society) C. Hu, F.W. Quelle, C.D. Sigmund. Univ. of Iowa and Sat. 1:00 pm—San Diego Convention Center, Room 23 California Inst. for Biomed. Res., La Jolla. (964.14) 3:30 Mycophenolate Mofetil Attenuates Hypertension Chaired: D.N. Jackson and I. Lamb in an Experimental Model of Systemic Lupus 1:00 Chair’s introduction. D. Jackson. Univ. of Erythematosus. E. Taylor, A. Strawder, M. Ryan. Western Ontario. Univ. of Mississippi Med. Ctr. (964.4) 1:15 Distinct Modes of Excitation-Contraction Coupling 3:45 Mingle with Open Bar. Encode Arteries with Spatial Properties. D. Welsh. Univ. of Western Ontario. 1:45 Potassium Sensing by Capillary Kir Channels Regulates Cerebral Blood Flow. T. Longden. Univ. of Vermont. Enhance Your EB Experience. 2:15 Propagation of Capillary-Initiated Conducted Download the App! Vasodilation in Skeletal Muscle – a Novel Paracrine Signaling Pathway. N.M. Novielli, C.L. Murrant. Univ. of Guelph, Canada. (945.17) The latest scientific sessions 2:30 Distinct EC Coupling Mechanism Drives Spatial Control of Vascular Tone in Cerebral Arteries. A. Zechariah, and Event information at your B.O. Hald, N.G. Mazumdar, D.G. Welsh. Univ. of fingertips. Western Ontario and Univ. of Copenhagen. (945.10) Download at http://m.core- 2:45 Chair’s Closing Remarks and Open Forum Q&A. D. apps.com/eb2016 Jackson. Univ. of Western Ontario. or scan the QR Code.

30 SATURDAY PHYSIOLOGY

Data Diuresis Brief Presentations Theme: Clinical Correlations Supported by: Data Sciences International 3:05 Intermittent Hypoxia Decreases Baroreflex Sensitivity Chaired: P. O’Connor and A. Polichnowski in Healthy Humans. Z.M. Scruggs, L.P. Newhouse, 4:15 Blood Pressure Regulation under Low K+ Intake M.J. Joyner, T.B. Curry, J.K. Limberg. Mayo Clin. Depends on the H,K-ATPase Type 2. G. Crambert, A. (753.5) Salhi, C. Lamouroux. Cordeliers Res. Ctr., INSERM 3:10 Sleep Apnea Worsens Muscle Vasoconstriction during U1138, CNRS, Paris. (1216.15) Central and Peripheral Chemoreceptors Stimulation S 4:20 The Predominant Role of Kidney in Sex Difference in in Patients with Systolic Heart Failure. D.M.L. Lobo, A Ang II-Induced Hypertension. L. Wang, R. Chen, J. P.F. Trevizan, E. Toschi-Dias, P.A. Oliveira, R.B. T Zhang, S. Rong, S. Wang, J. Wei, K-P. Yip, R. Liu. Piveta, C. Mady, E.A. Bocchi, D.R. Almeida, G. Univ. of South Florida and Hannover Med. Sch., Lorenzi-Filho, H.R. Middlekauff, C.E. Negrão. Heart Germany. (963.4) Inst., Univ. of São Paulo Med. Sch., Fed. Univ. of São 4:25 Effect of a Dietary and Exercise Intervention during Paulo and Geffen Sch. of Med. at UCLA. (755.6) Pregnancy and Lactation on White Adipose Tissue 3:15 Exaggerated Blood Pressure and Sympathetic Reactivity Gene Profiles and Adiposity with Maternal Obesity. M. in Patients with Type 2 Diabetes. J.R. Vranish, S.W. Symonds, I. Bloor, F. Galvez, E. Domfeh, B. Maicas, Holwerda, D.M. Keller, P.J. Fadel. Univ. of Texas at L. Poston, P. Taylor. Univ. of Nottingham, Fac. of Arlington and Univ. of Iowa. (1004.1) Med., Granada and King’s Col. London. (1214.3) 3:20 Discussion and Break. 4:30 High Salt Activates Dendritic Cells to Promote Hypertension. J.D. Foss, N. Barbaro, L. Xiao, S. Theme: Cell Signaling Dikalov, D.G. Harrison, A. Kirabo. Vanderbilt Univ. 3:35 Dysregulation of Cardiac cAMP in Nicotine Stimulated (1216.5) Sympathetic Neuronal-Myocyte Co-cultures from 4:35 Preserved Survival of Renal Tubulus-Specific Sodium Hypertensive Rats: Are Sympathetic Neurons the Hydrogen Exchanger Isoform 3 Knockout Mice in Primary Driver of Autonomic Hypertension? H.E. Response to Sodium Restriction. S. Chavez, S.B. Larsen, K. Lefkimmiatis, D.J. Paterson. Univ. of Poulsen, M. Soleimani, R.A. Fenton, T. Rieg. Oxford. (1006.7) UCSD and VA San Diego Healthcare Syst., Aarhus 3:40 Macrophage-Dependent Impairment of α2 Autoreceptor Univ., Denmark and Univ. of Cincinnati and VA Med. Inhibition of Ca2+ Currents in Sympathetic Neurons Ctr. (962.4) Contributes to Hypertension in DOCA-Salt Rats. R. 4:40 Chronic Insulin-Clamp Causes Postprandial Diuresis Mui, R. Fernandes, J. Galligan. Michigan State Univ. in Sprague Dawley Rats. D.L. Irsik, R. Alaisami, (757.8) A.R. Washington, M.W. Brands. Georgia Regents 3:45 Reduced Bone Marrow Adrenergic Receptor Signaling Univ. (962.2) Modulates PVN Inflammatory Factors. N. Ahmari, 4:45 Potential Role of Renal Mineralocorticoid Receptor J.T. Schmidt, C.T. Martyniuk, J. Zubcevic. Univ. of Increasing the Blood Pressure Sensitivity in Female Florida. (1237.6) Mice Exposed to Early Life Stress. M.O. Murphy, D. 3:50 Discussion and Break. Cohn, A.S. Loria. Univ. of Kentucky. (1213.5) 4:50 Mingle with Open Bar. Theme: Peripheral Autonomic Function

73. DATA NCARNATION 4:05 Effect of Renal Denervation and Celiac Ganglionectomy on Mean Arterial Pressure in the Hypertensive Award Session Schlager (BPH/2J) Mice. M.M. Gauthier, C. Breitenstein, N. Asirvatham-Jeyaraj, J.W. Osborn. (Sponsored by: APS Neural Control and Autonomic Univ. of Minnesota, Minneapolis. (1006.13) Regulation Section) 4:10 Possible Respiratory Modulation of Sympathetic Activity

Sat. 3:00 pm—San Diego Convention Center, Room 22 in Rats after Sino-aortic Denervation. M.R. Amorim, L.G. Bonagamba, G.M. Souza, D.J. Moraes, B.H. Chaired: M. Santisteban and E. Lazartigues Machado. Sch. of Med. of Ribeirão Preto, Univ. of São Paulo. (996.4) 3:00 Introduction. 4:15 Selective Beneficial Effects of Chronic Vagal Nerve Stimulation on Vascular Function in Stroke-Prone Spontaneously Hypertensive Rats on High-Salt Diet. E.E. Meyers, M.W. Chapleau, K. Rahmouni, H.M. Stauss. Univ. of Iowa and VA Med. Ctr. (1237.7) 4:20 Discussion and Break.

31 PHYSIOLOGY SATURDAY

Theme: Novel Methodologies 76. ADVANCES IN MICROVASCULAR PERMEABILITY/GLYCOCALYX 4:35 Effects of Essential Oil on Fear Memory and the Immune Response: A Potential Alternative Therapy Symposium for Post-traumatic Stress Disorder. C. Moshfegh, A.P. Swiercz, L. Hopkins, P.J. Marvar. George (Sponsored by: The Microcirculatory Society) Washington Univ. (1238.5) Sat. 3:30 pm—San Diego Convention Center, Room 23 4:40 An Optogenetic Test for the Functional Specificity of Bulbospinal Sympathoexcitatory Neurons. N.H. Chaired: J. Breslin Pracejus, D.G.S. Farmer, R.M. McAllen. The Florey Inst. of Neurosci. and Ment. Hlth., Parkville, Australia. 3:30 Chair’s introduction. J. Breslin. Univ. of South Florida. (1233.7) 3:30 Interactive Roles of ROS, NO, and RNS in the Regulation 4:45 Angiotensin Type 1a Receptors within the Paraventricular of Microvessel Permeability. P. He . Penn State Univ. Nucleus of Hypothalamus Regulate Cardiovascular 3:30 HS-FGF2-FGFR1 Signaling Contributes to Pulmonary and Behavioral Responsiveness to Psychological Endothelial Glycocalyx Reconstitution. E.P. Schmidt, Stress. L. Wang, A.D. de Kloet, J.A. Smith, H. Hiller, Y. Yang, M. Suflita, F. Zhang, K. Dailey, S. Haeger, C. Sumners, M.K. Raizada, E.G. Krause. Univ. of J. Ford, R. Linhardt. Univ. of Colorado, Aurora and Florida. (1238.4) Rensselaer Polytech Inst. (950.4) 4:50 Discussion and Wrap-up. 3:30 Hydrogen Sulfide Metabolism Regulates Endothelial Permeability. S. Yuan, S. Pardue, A.W. Orr, C.G. 74. SETTING THE RECORD STRAIGHT FOR Kevil. LSU Hlth. Sci. Ctr., Shreveport. (950.12) 3:30 Lymphatic Vascular Integrity Is Disrupted in a Mouse SCIENCE: HOW TO WRITE TO LOCAL AND Model of Diabetes: Dual Regulation by Nitric Oxide. NATIONAL NEWS OUTLETS J.P. Scallan, M.A. Hill, M.J. Davis. Univ. of South Florida and Univ. of Missouri-Columbia. (950.9) Symposium 3:30 Functional Significance of eNOS Traffic. W. Duran. (Sponsored by: APS Communications Committee) Rutgers Univ.

Sat. 3:00 pm—San Diego Convention Center, Room 25C 77. PHYSIOLOGY IN PERSPECTIVE: THE WALTER Chaired: B. Goodman B. CANNON MEMORIAL AWARD LECTURE

Science Policy Lecture Panel Discussion. B. Yates and M. Aguilera. Univ. of Sat. 5:30 pm—San Diego Convention Center, Ballroom 20A Pittsburgh and Scripps Inst. of Oceanography, UCSD. Muscle-Immune Cell Crosstalk in the Genesis of Insulin 75. NOVEL METHODS TO PERTURB GENES FOR Resistance. A. Klip. Hosp. for Sick Children, Toronto. PHYSIOLOGICAL EXAMINATION 78. MICROCIRCULATORY SOCIETY Workshop POSTER DISCUSSION

3:15 pm—San Diego Convention Center, Room 26 Special Session Chaired: B.T. Andresen and B. Joe (Sponsored by: The Microcirculatory Society)

3:15 Cellular Genomic Editing. D. Hockemeyer. Univ. of Sat. 6:00 pm—San Diego Convention Center, Room 27 California, Berkeley. 3:45 Introduction to the RCAS/TVA System – A Tissue Chaired: W.L. Murfee, A. Gonzalez and J. Song Specific Expression System. E. Holland. Light refreshments will be available Fred Hutchinson Cancer Res. Ctr. 4:15 Choosing the Right Genome Editing Technology: CRISPR, TARGATT™, or Homologous Recombination? R. Chen-Tsai. Applied StemCell Inc., Menlo Park, CA. 4:45 Round Table Discussion.

32 SUNDAY, APRIL 3 Across Societies

79. NIH K AWARDS Poster/Platform Presenter Preparation Workshop and Practice Lab Seminar FASEB MARC Program will sponsor a Poster/Platform Sun. 9:00 am—San Diego Convention Center, Presenter Preparation Workshop and Practice Lab beginning Exhibit Hall D Saturday, April 2, to provide FASEB MARC poster/oral presentation travel award recipients and other interested EB2016 S NIH Grants Seminar student/postdoc attendees with an opportunity to practice their U Career Development presentations and obtain feedback from designated Workshop Mentors/Coaches. If you would like to participate in this N This presentation, by Dr. Henry Khachaturian of NIGMS, NIH, workshop/practice lab, sign-up onsite at the Career Center will focus on the NIH’s new K99/00 Pathways to Independence beginning Saturday morning, April 2. First-come, first- Award (for postdoctoral scientists) and the K08 Mentored Clinical served. Limited space/session availability. Scientist Development Award (for individuals with a health professional doctoral degree committed to a career in laboratory 9:00 Making Mistakes When Speaking: How to Handle Them. or field-based research). The interactive discussion will give J. Blumenthal. Montgomery Col., MD. attendees an opportunity to ask questions of and obtain insight 9:30 Nailing the Job Talk & Interview Prep. A. Green. Univ. of from an NIH representative. California, Berkeley. 9:30 Global Interview Skills: A Practice Workshop for International Candidates. D. Behrens. Univ. of 80. NIH FELLOWSHIP (F) AWARDS California, Berkeley. 10:00 Responsible Conduct of Research Part 1: Historical Seminar Perspectives: Past Controversies, Successes, and Present Challenges. S. Sodeke, T. Turner. Tuskegee Sun. 1:00 pm—San Diego Convention Center, Univ., Jackson State Univ. Exhibit Hall D 10:30 Making the Case for Graduate School. H. Adams. H.G. NIH Grants Seminar Adams & Assocs. Inc., Norfolk, VA. 11:00 Job Hunting in Biotech Part 1: Finding & Applying for Career Development Scientist Positions. B. Lindstaedt. UCSF. This presentation, by Dr. Henry Khachaturian of NIGMS, 11:00 Ten Ways to Get Lucky in the Job Search. P. Clifford. NIH, will focus on the NIH’s Ruth L. Kirschstein National Research Med. Col. of Wisconsin and Marquette Univ. Service Awards (NRSA). The NRSA research training fellowship 11:00 Job Talk/Chalk Talk: Making the Grade. D. Behrens. (F) awards are targeted to individuals with or seeking research Univ. of California, Berkeley. doctoral degrees (Ph.D. and equivalent) and clinical doctoral 1:00 Identifying Your Options using ScienceCareers. degrees (M.D. and equivalent). Among the F awards discussed org, LinkedIn & More. A. Green. Univ. of will be the F30, NRSA Individual Predoctoral MD/PhD or Other California, Berkeley. Dual-Doctoral Degree Fellowship Award, the F31 NRSA Individual 1:00 Networking with Strangers is Required for Your Future. Predoctoral Fellowship, the F31 NRSA Individual Predoctoral J. Blumenthal. Montgomery Col., MD. Fellowship to Promote Diversity in HealthRelated Research 1:00 Responsible Conduct of Research Part 2: Best Award, the F32 NRSA Individual Postdoctoral Fellowship Award, Practices: Mentoring, Collaboration, Peer Review, and the NRSA Individual Senior Fellowship Award. The interactive Data Management and Ownership. S. Sodeke, T. discussion will give attendees an opportunity to ask questions Turner. Tuskegee Univ., Jackson State Univ. of and obtain insight from an NIH representative on these and 1:30 Job Hunting in Biotech Part 2: Interviewing for Scientist other awards available for pre- and postdoctoral fellows and Positions. B. Lindstaedt. UCSF. senior investigators. 2:30 Talking About Yourself: How to Interview Well. N. Saul. UCSF. Handouts and resource materials will be provided on-site. 2:30 Ten Tough Industrial Interview Questions (and Ten Pretty Good Responses). J. Tringali. Tringali & Assocs. Inc. 81. CAREER DEVELOPMENT WORKSHOPS 3:30 But I Have No Skills! J. Lombardo. Med. Col. of Wisconsin and Marquette Univ. Workshop 4:00 Job Hunting in Biotech Part 3: Compensation Negotiation for Scientist Positions. B. Lindstaedt. UCSF. Sun. 9:00 am—San Diego Convention Center, 4:00 Developing & Writing the Doctoral Dissertation Proposal. Exhibit Hall D H. Adams. H.G. Adams & Assocs. Inc., Norfolk, VA. Career Development The following workshops will be held in the EB2016/FASEB Career Center. Access to the Career Center is FREE to all registered Experimental Biology 2016 meeting attendees.

33 ANATOMY SUNDAY Anatomy

82. NEURAL STEM CELLS AND 84. TISSUE GENERATION AND TRANSPLANTATION NEOCORTICAL DEVELOPMENT Minisymposium Plenary Sun. 10:30 am—San Diego Convention Center, Room 9 (Cosponsored by: Developmental Dynamics) Chaired: K. Kramer Sun. 8:30 am—San Diego Convention Center, Room 9 Stem Cells/ Regeneration Chaired: B. Allman Tissue Bioengineering Neurobiology Regenerative Medicine (Stem Cells, Tissue Stem Cells/ Regeneration Regeneration, Biomaterials) Regenerative Medicine (Stem Cells, Tissue This session is part of the Stem Cells Mini-Meeting Regeneration, Biomaterials) 10:30 84.1 Tissue Engineering: Simple versus Complex This session is part of the Stem Cells Mini-Meeting Organs. L. Sampaio. Texas Heart Inst., Houston. 11:00 Bioinspired Matrices Orchestrate Stem Cell 8:30 New Insights into Neurogenesis and Migration in the Engraftment through Vascular Integration. K. Healy. Univ. of Developing Human Neocortex. A. Kriegstein. UCSF. California, Berkeley. 9:15 Generation of Functionally Distinct Projection Neurons 11:30 Title TBD. A. Sacco. Sanford Burnham Prebys Med. in the Mammalian Neocortex. U. Mueller. The Scripps Discovery Inst. Res. Inst. 85. ANATOMY EDUCATION ROUNDTABLE - 83. DEVELOPMENTAL BIOLOGY AWARD ANATOMICAL CONTENT: WHAT TO TEACH IN A HYBRID SYMPOSIUM MODERN MEDICAL CURRICULUM Hybrid Symposium Education Roundtable Sun. 10:30 am—San Diego Convention Center, Room 10 (Cosponsored by: Anatomical Sciences Education) Chaired: D. Hockemeyer Sun. 10:30 am—San Diego Convention Center, Room 8 Developmental Biology/Morphology Cochaired: M. Bee and V. Lyons H.W. Mossman Award Lecture in Developmental Biology Education and Teaching featuring 2016 Young Investigator Award Recipient, Michael Jenkins. Nicholas Mignemi is competing as a finalist in the In this session the collective wisdom of the group will be Postdoctoral Platform Presentation Award leveraged to determine essential content for histology, gross anatomy and neuroscience. 10:30 83.1 Optical Tools to Assess Heart Development. M.W. Jenkins. Case Western Reserve Univ. Continental Breakfast will be provided, based on availability. 11:00 83.2 Cranial Neural Crest Migration Sculpts 10:30 Anatomical Sciences in Medical Curriculum: Looking Endothelial Patterning in Avians with Anti-angiogenic Factors. Backward and Forward. M.C. McKinney, P. Kulesa. Stowers Inst. for Med. Res., 10:45 Group Activities: Leveraging the Collective Wisdom Kansas City, MO. (1029.3) of AAA. 11:15 83.3 Plasminogen Is Essential to Prevent 11:45 Conclusion. Heterotypic Ossification following Traumatic Muscle Injury. N. Mignemi, R.C. Ihejirika, Y. Ihejirika, C. Wallace, W. Oeslner, C.E. Baker, J. Schoenecker. Vanderbilt Univ. 86. AXIAL ANATOMY IN PRIMATES: LOCOMOTION, 11:30 83.4 Regulating Skeletal Progenitor Cells at the POSTURE AND EVOLUTION Interface between Tendon and Bone. A.E. Merrill, R. Roberts. Univ. of So. California. Symposium 11:45 83.5 Genetic Tools for Study of the Hypothalamus (Cosponsored by: The Anatomical Record) and Thyroid in Zebrafish. D. Hutcheson, Y. Xie, R. Duncan, R. Dorsky. Univ. of Utah. Sun. 2:00 pm—San Diego Convention Center, Room 10

Chaired: C. Ward

Evolution/Anthropology 2:00 86.1 Functional Morphology and Evolution of the Human Trunk Musculature – Old and New Features. N. Schilling. Friedrich Schiller Univ. Jena, Germany.

34 SUNDAY ANATOMY

2:30 86.2 Determinants of Variation in Trunk Morphology 89. CRANIAL SENSORY ORGANS: FROM in Anthropoid Primates. C.V. Ward, E.R. Middleton. Univ. PLACODES TO DISEASE of Missouri-Columbia. 3:00 86.3 Three-Dimensional Trunk Kinematics of Symposium Humans and Chimpanzees: New Insights on Early Hominin Bipedalism. N.E. Thompson, B. Demes, M.C. O’Neill. Stony Sun. 2:00 pm—San Diego Convention Center, Room 7B Brook Univ., Univ. of Arizona Col. of Med., Phoenix. Chaired: L. Taneyhill 3:15 86.4 Functional and Behavioral Consequences of Axial Stability in Primates and Other . M.C. Neurobiology Granatosky. Duke Univ. Cell Biology This session was funded in part by an AAA Three-Year 87. MANIPULATION OF SUBSTRATE PROPERTIES S FOR IMPROVED CONSTRUCTION OF STEM Research Meetings Outreach Grant U CELL-BASED BIOMATERIALS 2:00 89.1 In Search of Novel Genes in Branchio-oto-renal Spectrum Disorders. S.A. Moody. George Washington Univ. N Minisymposium 2:30 89.2 Cranial Nerve Dysmorphogenesis in 22Q11 Deletion (DiGeorge) Syndrome. A-S. LaMantia, B.A. Sun. 2:00 pm—San Diego Convention Center, Room 9 Karpinski, T.M. Maynard, S.A. Moody, D. Mendelowitz, X. Cochaired: E. Alsberg and D. Mills Wang, A. Popratiloff, I. Zohn, N.H. Lee. George Washington Univ. Sch. of Med. & Hlth. Sci. and Children’s Natl. Med. Ctr. Stem Cells/ Regeneration 3:00 89.3 Mechanisms of Otoconia Development and Tissue Bioengineering Clinical Translation. Y. Lundberg. Boys Town Natl. Res. Hosp., Omaha. This session is part of the Stem Cells Mini-Meeting 2:00 87.1 3D-Printing and Casting of Biological 90. MODERN IMAGING APPROACHES TO Constructs for Generating Stem Cell-Based Scaffolds. J.S. STUDYING ANIMAL FORM AND FUNCTION Alexander, Y. Wang, B. Ott, M. Al-Kofahi, D.K. Mills. LSU Hlth. Sci. Ctr. and Southwood H.S., Shreveport and Louisiana Symposium Tech Univ. 2:30 87.2 Dynamic Stiffness Reveals New Cardiac Sun. 4:00 pm—San Diego Convention Center, Room 10 Phenotypes in Patient-Derived iPSCs. A.J. Engler. UCSD. Chaired: C. Holliday 3:00 87.3 Development of Biologically Inspired 3D Printed Biomaterial Scaffolds for Improved Stem Cell Differentiation. Evolution/Anthropology L.G. Zhang. George Washington Univ. Developmental Biology/Morphology

88. PROBING DEEPER: QUALITATIVE RESEARCH 4:00 90.1 Visualizing Microaggression in the Developing IN ANATOMY EDUCATION Embryo: Competition between the Neural Crest and Endothelial Cells. P. Kulesa. Stowers Inst., Kansas City, MO. 4:30 90.2 Contrast Enhanced Imaging Approaches for Symposium Studying Vertebrate Form and Function. C.M. Holliday. Univ. Sun. 2:00 pm—San Diego Convention Center, Room 8 of Missouri-Columbia. 5:00 90.3 Insights into the Underwater Behavior, Chaired: M. Hankin Species Interactions, and Biomechanics of Baleen Whales Education and Teaching Using Suction-Cup Attached Video and Inertial Sensors. J. Goldbogen, D. Cade, J. Calambokidis, A. Stimpert, A. 2:00 88.1 Students’ Understandings of Their Ethical Friedlaender. Stanford Univ., Pacific Grove, Cascadia Res., Obligations to Their Cadavers after Their First Anatomy Lab: Olympia, WA, Moss Landing Marine Labs., CA and Oregon A Qualitative Study. J. Fortunato, J. Wasserman, M. Hankin. State Univ. Oakland Univ. William Beaumont Sch. of Med. and Univ. of Virginia Sch. of Med. 2:30 88.2 Qualitative Methods: An Overview for Anatomy Education Research. J.A. Wasserman. Oakland Univ. William Beaumont Univ. Sch. of Med. 3:00 88.3 Using Mixed Methods Research in Anatomy Education: The Relevancy, Challenges, and Benefits. E. Fillmore. Univ. of Buckingham Med. Sch., U.K.

35 ANATOMY SUNDAY

91. CREATING STRUCTURED 93. MICROGLIA FUNCTION AND ACTIVATION IN MICROENVIRONMENTS FOR REGULATING THE CNS STEM CELL DIFFERENTIATION Symposium Minisymposium Sun. 4:00 pm—San Diego Convention Center, Room 7B Sun. 4:00 pm—San Diego Convention Center, Room 9 Chaired: K. Jones Cochaired: L.G. Zhang and D. Mills Neurobiology Stem Cells/ Regeneration Cell Biology Tissue Bioengineering 4:00 TREM2 Dependent Microglia Functions This session is part of the Stem Cells Mini-Meeting in TBI and Brain Inflammation. M. Carson. Univ. of California, Riverside. 4:00 91.1 Stem Cell Proliferation and Differentiation 4:30 93.1 Redox Regulation of the M1/M2 Shift in through Capped Clay Nanotubes. S.J. Karnik, D. Robinson. Microglia: Programming the Deleterious Phenotype. M.L. Louisiana Tech Univ. Block. Indiana Univ. Sch. of Med. 4:30 91.2 Strategies for Inducing Spatially Defined 5:00 93.2 Responses of Central Microglial Cells and Stem Cell Differentiation for Tissue Engineering Applications. Ganglionic Macrophages to Peripheral Injury and Disease. E. Alsberg. Case Western Reserve Univ. M. Kawaja. Queen’s Univ., Canada. 5:00 91.3 Microfluidic Systems for Stem Cell Studies.L. Tayebi. Marquette Univ. Sch. of Dent. 94. AAA UNDERGRADUATE POSTER RECEPTION

92. APPLIED 3D PRINTING IN ANATOMICAL AND Poster Discussion MEDICAL EDUCATION AND RESEARCH Sun. 5:30 pm—San Diego Convention Center, West Symposium Terrace Lobby

Sun. 4:00 pm—San Diego Convention Center, Room 8 95. MARIAN DIAMOND DOCUMENTARY Chaired: J. Bertram SCREENING AND RECEPTION Education and Teaching Special Event 4:00 92.1 3D Printed Anatomical Teaching Material – A Genuine Alternative? P.G. McMenamin. Monash Sun. 6:30 pm—San Diego Convention Center, Room 10 Univ., Australia. Join us for a special 25-minute sneak peek of a documentary 4:30 92.2 3D Printing in Anatomical and Palaeontological screening of, “My Love Affair with the Brain: The Life and Science Teaching and Research. J.W. Adams. Monash Univ., Australia. of Marian Diamond.” Dr. Diamond is one of the founders of 5:00 92.3 Virtual Surgical Planning and Applications modern neuroscience and has revolutionized the way we think in Plastic and Craniomaxillofacial Surgery. S. Basel, J. about how the brain ages. Light refreshments will be served Matsumoto, N. Lachman, U. Bite. Mayo Clin. and a Q&A session with the documentary producers will follow the screening.

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36 SUNDAY BIOCHEMISTRY Biochemistry and Molecular Biology

96. FASEB EXCELLENCE IN SCIENCE AWARD 99. NUCLEAR ARCHITECTURE AND CHROMATIN ORGANIZATION Award Lecture Symposium Sun. 8:00 am—San Diego Convention Center, Room 6B Sun. 9:45 am—San Diego Convention Center, Room 1B 8:00 Awardee introduction. 8:05 96.1 Quorum Sensing and Its Control. B.L. Bassler. Chaired: J.W. Conaway Princeton Univ. and HHMI. Follow the conversation: #chromatin S 97. ASBMB PLENARY LECTURE 9:45 Chair’s Introduction. U 9:50 99.1 The 3D Organization of the Mammalian Plenary Genome. B. Ren. UCSD N 10:15 Chromatin Extrusion Explains Key Features Sun. 8:45 am—San Diego Convention Center, Room 6B of Loop and Domain Formation in Wild-Type and Engineered 8:45 Awardee introduction. . A. Sanborn, S. Rao, S-C. Huang, N. Durand, M. 8:50 97.1 From Protein Folding to Cognition: Huntley, A. Jewett, I. Bochkov, D. Chinnappan, A. Cutkosky, The Serendipitous Path of Discovery. P. Walter. UCSF, HHMI. J. Li, K. Geeting, A. Gnirke, A. Melnikov, D. McKenna, E. Stamenova, E. Lander, E.L. Aiden. Baylor Col. of Med., 98. REGULATION OF GENE EXPRESSION BY Stanford Univ. Sch. of Med. and Broad Inst. of MIT and Harvard. O-GLCNAC (588.1) 10:30 99.2 Long-Range Gene Regulation in the Symposium Context of Chromatin Domains. J. Dekker. Univ. of Massachusetts, Worcester. Sun. 9:45 am—San Diego Convention Center, Room 1A 10:55 Enhancer H3K4 Methyltransferase MLL4 Controls Cell Fate Transition. K. Ge. NIDDK, NIH. (802.1) Chaired: C.M. Szymanski 11:10 BRD4 Is a Histone Acetyltransferase That Follow the conversation: #glyco Evicts Nucleosomes from Chromatin. D.N. Ballachanda, C. Case-Borden, A. Gegonne, C.H. Hsu, Q. Chen, D. 9:45 Chair’s Introduction. Meerzaman, A. Dey, K. Ozato, D. Singer. NCI, NIH, Bethesda 9:50 98.1 O-GlcNAcylation Links ChREBP to Glucose and Rockville and NICHD, NIH. (802.5) Sensing in Liver and Pancreatic Cells. G. Filoulaud, F. β 11:25 99.3 Complex Multi-enhancer Contacts Captured Rayah-Benhamed, C. Guinez, B. Noblet, Y. Fardini, T. Issad, by Genome Architecture Mapping, a Novel Ligation-Free C. Postic. Univ. Paris Descartes. Approach. A. Pombo, R.A. Beagrie, A. Scialdone, M. 10:15 Elevated O-GlcNAcylation Levels Improve Schueler, M. Chotalia, S.Q. Xie, D. Kraemer, I. de Santiago, Mitochondrial Function. E.P. Tan, R. Swerdlow, C. Slawson. J. Fraser, J. Dostie, L. Game, N. Dillon, P.A.W. Edwards, M. Univ. of Kansas Med. Ctr. (845.1) Nicodemi. Berlin Inst. for Med. Systs. Biol., Imperial Col. Sch. 10:30 98.3 Initiation and Elongation of RNA Polymerase II of Med., U.K., Univ. of Naples Federico II, McGill Univ. and Are Regulated by Multiple O-GlcNAcylation Events. B.A. Lewis. Univ. of Cambridge. NCI, NIH. 11:50 Discussion. 10:55 O-GlcNAcylation of the Human Kinome. X. Liu, G. Han, L. Wells, L. Graves, H. Zhu, J. Neiswinger, G.W. Hart. Johns Hopkins Univ., Univ. of Gerogia and Univ. of Illinois at 100. WELCOME TO THE POST-ANTIBIOTIC ERA Urbana-Champaign. (845.2) 11:10 Dynamic Interactions of TATA-Box Binding Symposium Protein with Promoters Is Regulated by O-GlcNAcylation. Sun. 9:45 am—San Diego Convention Center, Room 6C S. Hardivillé, G. Han, J. Ma, P. Hu, P.S. Banerjee, G.W. Hart. Johns Hopkins Univ. Sch. of Med. (617.1) Chaired: J. Prescher 11:25 98.5 Mutations in O-GlcNAc Transferase Linked to Follow the conversation: #chembio X-Linked Intellectual Disability. L. Wells. Univ. of Georgia 11:50 Discussion. 9:45 Chair’s Introduction. 9:50 100.1 Chemical Probes for Histidine Kinase Profiling and Inhibitor Discovery. E. Carlson. Univ. of Minnesota, Minneapolis. 10:15 Acetylating Polymyxin Antibiotics: Clues toward Substrate Specificity of PA3944 Gcn5-Related N-Acetyltransferase of Unknown Function. M.L. Kuhn, L. Joe, B. Amsler, B. Zhang, K. Majorek, R. Yen, W. Wu, G. Gassner, T. Baird, W. Minor. San Francisco State Univ. and Univ. of Virginia. (615.1)

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10:30 100.2 The Ying and Yang of Antibiotic Discovery and 102. ALLOSTERIC CONTROL OF KINASE ACTIVITY Resistance. G. Wright. McMaster Univ., Canada. 10:55 Menaquinone Biosynthesis: An Antibacterial Symposium Target? J. Matarlo. Stony Brook Univ. (612.2) 11:10 Elucidating the Molecular Basis of Protein Sun. 9:45 am—San Diego Convention Center, Room 6E and Polymer Display in Pathogenic Bacteria for Novel Anti- Chaired: S. Taylor virulence Drug Development. M. Kattke, M. Sawaya, D. Cascio, A. Duong, M. Elliot, R. Clubb. UCLA and McMaster Follow the conversation: #cellsignal Univ., Canada. (613.3) 9:45 Chair’s Introduction. 11:25 100.3 New Antibiotics for the Post-antibiotic Era. 9:50 102.1 Dimer Induced Regulation of Protein Kinase S. Mobashery. Univ. of Notre Dame. Function. F. Sicheri. Lunenfeld-Tanenbaum Res. Inst., Mount 11:50 Discussion. Sinai Hosp., Toronto. 10:15 Phosphorylation of Secreted Proteins by a 101. PROTEOMICS/SYSTEMS BIOLOGY FOR New Family of Kinases. V.S. Tagliabracci, S. Wiley, J. Dixon. HUMAN HEALTH AND MEDICINE Univ. of Texas Southwestern and UCSD. (633.7) 10:30 102.2 How EGF and Insulin Activate Their Receptors. Symposium D. Leahy. Johns Hopkins Univ. Sch. of Med. 10:55 Designing Allosteric Switches of Kinases. N.V. Sun. 9:45 am—San Diego Convention Center, Room 6D Dokholyan, O. Dagliyan, K. Hahn. Univ. of North Carolina at Chaired: L. Huang Chapel Hill. (633.6) 11:10 Protein Dynamics Defines Allostery in the Follow the conversation: #proteomics Conserved EPK Core. L.G. Ahuja, A.P. Kornev, C. McClendon, 9:45 Chair’s Introduction. G. Veglia, S. Taylor. UCSD and Univ. of Minnesota, Minneapolis. 9:50 101.1 Spatiotemporal Organization of Signaling: (856.10) From Plasma Membrane to Chromatin. A-C. Gingras. 11:25 102.3 Signaling in the Catalytic Subunit of Lunenfeld-Tanenbaum Res. Inst., Toronto and Univ. of Toronto. Protein Kinase A via Hydrophobic Motifs. G. Veglia. Univ. of 10:15 Global Ubiquitylome Profiling for the Minnesota, Minneapolis. Identification of Drug Targets in Cancer. N.D. Udeshi, J. 11:50 Discussion. Kronke, E. Fink, T. Svinkina, M. Schenone, B. Ebert, S.A. Carr. Broad Inst. of MIT and Harvard, Univ. Hosp. of Ulm, 103. HEPATIC LIPID SIGNALING: NAFLD Germany and Brigham and Women’s Hosp. (819.6) AND BEYOND 10:30 101.2 Human Proteomes – From Basic Science to Understanding Drug Action. B. Kuster. Technical Univ., Munich Symposium and Friesing, Germany. 10:55 Rapid and Reproducible Proteotype (Sponsored by: ASBMB Minority Affairs Committee) Acquisition from Biopsy Level Samples. T. Guo, R. Aebersold. Sun. 9:45 am—San Diego Convention Center, Room 6F ETH Zurich. (602.2) 11:10 Mechanism of Action Identified in 30 Days: A Chaired: D.D. Moore Systems Biology Approach. A. Vertes, A.R. Korte, C. Lombard- Follow the conversation: #liver Banek, P. Nemes, L. Lida Parvin, Z.J. Sahab, B. Shrestha, S.A. Stopka, W. Yuan, D.I. Bunin, M. Knapp, I. Mason, D.M. 9:45 Chair’s Introduction. Nishita, A. Poggio, C.L. Talcott, M. Yadav, B.M. Davis, A.I. 9:50 103.1 Regulation of Liver Energy Balance by Nuclear Larriera, C.A. Morton, C.J. Sevinsky, M.I. Zavodszky, N.J. Receptors. D.D. Moore. Baylor Col. of Med. Morris, H.R. Anderson, M.J. Powell, T.T. Razunguzwa. 10:15 Sphingosine-1-Phosphate Signaling in Non- George Washington Univ., SRI Intl., Menlo Park, GE Global alcoholic Steatohepatitis. L.A. Cowart. Med. Univ. of South Res., Niskayuna, NY and Protea Biosci. Inc., Morgantown, WV. Carolina. (870.6) (819.2) 10:30 103.2 Hedgehog Signaling in NAFLD. A.M. Diehl. 11:25 101.3 Proteotyping for Drug Development: Duke Univ. Med. Ctr. Proteomics Impacting Clinical Practice. J. Van Eyk, R. 10:55 FTY720/fingolimod Reduces Steatosis Holewinski, S. Wang, J. Kirk, D. Kass. Cedars-Sinai Med. in a Murine Model of Non-alcoholic Fatty Liver Disease. Ctr., Johns Hopkins Univ. and Loyola Univ. Chicago. T.D. Rohrbach, A. Asgharpour, D. Avni, S.C. Cazanave, P. 11:50 Discussion. Bedossa, A.J. Sanyal, S.D. Spiegel. Virginia Commonwealth Univ. and Univ. Paris-Denis Diderot. (870.7) 11:10 Dual Activation of Bile Acid Receptors FXR and TGR5 Plays a Protective Role in Non-alcoholic Fatty Liver Disease and Atherosclerosis. K. Jadhav, Y. Xu, Y. Zhang. Northeast Ohio Med. Univ. (870.4) 11:25 103.3 JNK Signaling in Hepatic Disease. R.J. Davis. HHMI/Univ. of Massachusetts Med. Sch. 11:50 Discussion.

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104. ADVANCING TEACHING AND LEARNING 106. ASBMB INCENTIVIZING GREAT RESEARCH IN THE BIOCHEMISTRY/MOLECULAR BIOLOGY CLASSROOM Public Policy (Sponsored by: ASBMB Public Affairs Symposium Advisory Committee)

(Sponsored by: ASBMB Education and Professional Sun. 12:30 pm—San Diego Convention Center, Room 6A Development Committee) This symposium will focus on analyzing counterproductive Sun. 9:45 am—San Diego Convention Center, Room 14A pressures on scientists and how they can be managed to Chaired: C. Peterson incentivize outstanding research. Follow the conversation: #education S 107. EARL AND THRESSA STADTMAN SCHOLAR U 9:45 Chair’s Introduction. AWARD LECTURE I 9:50 104.1 Take Your Medicine; It’s Good for You. N Teaching Quantitative Principles to Biologists. M. Springer. Award Lecture Harvard Med. Sch. 10:15 Teaching a Broad Non-science Major Audience Sun. 2:15 pm—San Diego Convention Center, Room 6B Using the Science of Food and Cooking. J.J. Provost, B. 2:15 Awardee introduction. Kelly, K. Colabroy, M. Wallert. Univ. of San Diego, Gustavus 2:20 107.1 CRISPR-Cas, the Prokaryotic Adaptive Adolphus Col., MN, Muhlenberg Col., PA and Bemidji State Immune System. L. Marraffini. The Rockefeller Univ. Univ. (882.2) 10:30 104.2 The Collaborative Undergraduate Research Lab: Using Yeast to Create an Authentic Research 108. RUTH KIRSCHSTEIN DIVERSITY IN SCIENCE Experience for Freshman. T. Johnson. HHMI, UCLA. AWARD LECTURE 10:55 Is More Activity Always Better? A Department- Wide Study of Relationships between Classroom Practices Award Lecture and Student Performance. M.K. Barker, L. Weir, L. McDonnell, Sun. 2:40 pm—San Diego Convention Center, Room 6B N. Schimpf, T. Rodela, P. Schulte. Univ. of British Columbia, Kwantlen Polytech Univ., Canada and UCSD. (662.17) 2:40 Awardee introduction. 11:10 Breast Cancer in the Age of Personalized 2:45 108.1 Chemical Genetic Analysis of Mast-Cell Medicine: A CURE Design for Aspiring Physicians. P.A.G. Activation. A. August. Cornell Univ. Soneral. Bethel Univ. (662.18) 11:25 104.3 Using Threshold Concepts to Improve BMB 109. AVANTI AWARD IN LIPIDS LECTURE Instruction – An Evidence-Based Approach. J. Loertscher, J. Lewis, V. Minderhout, X. Xu. Seattle Univ. and Univ. of Award Lecture South Florida. 11:50 Discussion. (Sponsored by: Avanti Polar Lipids, Inc.) Sun. 3:15 pm—San Diego Convention Center, Room 6B 105. ASBMB AWARD FOR EXEMPLARY 3:15 Awardee introduction. CONTRIBUTIONS TO EDUCATION LECTURE 3:20 109.1 Mechanisms and Physiology of Fat Synthesis and Storage. R.V. Farese. Harvard Med. Sch. Award Lecture (Sponsored by: ASBMB Education and Professional 110. TRANSLATIONAL SCIENTIST: INTEGRATING Development Committee) SCIENCE AND MEDICINE

Sun. 12:30 pm—San Diego Convention Center, Room 6B Symposium Undergraduate Student Research Poster Competition Award Winners will be announced during this lecture. (Supported by Guest Society: Society for Experimental Biology and Medicine) 12:30 Awardee introduction. 12:35 105.1 Biochemistry and Molecular Biology Education Sun. 4:00 pm—San Diego Convention Center, Room 1A in a Transforming Academy and a Molecular World. C. Brenner. Cochaired: H.R. Gaskins and W.E. Zimmer Univ. of Iowa Carver Col. of Med. New Approaches in Medical Training of Health Researchers M. J. Friedlander, Virginia Tech Carilion Res Inst Forging Interactions Between Academia, Industry and Clinical Health Care Providers M. Wood, AstraZeneca Neuroscience

39 BIOCHEMISTRY SUNDAY

111. REPLICATION: ALPHA TO OMEGA 113. REGULATION OF PROTEIN SYNTHESIS BY RNA

Symposium Symposium

Sun. 4:00 pm—San Diego Convention Center, Room 1B Sun. 4:00 pm—San Diego Convention Center, Room 6D

Chaired: A. Smogorzewska Chaired: Y. Ye

Follow the conversation: #DNA Follow the conversation: #proteins 4:00 Chair’s Introduction. 4:00 Chair’s Introduction. 4:05 111.1 Single-Molecule Studies of Eukaryotic DNA 4:05 113.1 Regulation of the mRNA Reading Frame. Replication. S.P. Bell, S. Ticau, L.J. Friedman, J. Gelles. MIT C.M. Dunham, S. Sunita, J. Dunkle, T. Maehigashi. Emory and Brandeis Univ. Univ. Sch. of Med. 4:30 Flexible Modes of Translocation by the 4:30 Translational Recoding in Human Disease. Eukaryotic CMG Helicase Facilitate Removal or Bypass of V.M. Advani, R.C. Kobylarz, J.D. Dinman. Univ. of Maryland DNA Blocks. L.D. Langston, M. O’Donnell. HHMI, Rockefeller College Park. (1065.1) Univ. (578.4) 4:45 113.2 Structured That Manipulate the 4:45 111.2 Structural Mechanisms for Initiating DNA Translation Machinery. J.S. Kieft. Univ. of Colorado Med. Sch. Replication. J. Berger. Johns Hopkins Univ. Sch. of Med. 5:10 Coaxing a Viral RNA Out of Its Shell: How 5:10 Function of Cdc45 in DNA Replication and Does a Viral RNA Genome Initiate Contact with Its Host? in Response to Genotoxic Stress. A. DeBrot, C. Lancaster, R.W. Sportsman, C. Beren, B. Kartub, R. Garmann, M-A. Bjornsti. Univ. of Alabama at Birmingham and St Jude C. Knobler, W. Gelbart. UCLA and Harvard Univ. Sch. of Children’s Res. Hosp. (798.2) Engin. and Applied Sci. (599.3) 5:25 Breaking the Fourth Wall: Quaternary 5:25 mRNA Quality Control Is Activated Due to Organizations Forge a Link to the Novel Non-enzymatic Chromium (VI) Mediated Oxidative Damage. N. Garcia- Function of RNR-α. Y. Aye. Cornell Univ. and Weill Cornell Doherty, A.L. Larson, M. Six, S.P. Segal. Winona State Univ. Med., Ithaca. (793.1) (599.1) 5:40 111.3 Replisome Disassembly at the Termination 5:40 113.3 Ribosome-Based Quality Control of Chemically of Eukaryotic Replication Forks. A. Gambus. Univ. of Damaged mRNA. H. Zaher, C.L. Simms, B.H. Hudson. Birmingham, U.K. Washington Univ. in St. Louis. 6:05 Discussion. 6:05 Discussion.

112. MECHANISTIC STUDIES 114. OMICS APPROACHES TO TARGET DISCOVERY OF METALLOENZYMES Symposium Symposium Sun. 4:00 pm—San Diego Convention Center, Room 6E Sun. 4:00 pm—San Diego Convention Center, Room 6C Chaired: J. Sello Chaired: V. Bandarian Follow the conversation: #metabolism Follow the conversation: #catalysis 4:00 Chair’s Introduction. 4:00 Chair’s Introduction. 4:05 114.1 Metabolomic Signatures of Antimycobacterial 4:05 112.1 DNA-Mediated Signaling by Proteins with Iron- Drug Mechanisms of Action. K. Rhee. Weill Cornell Med. Col. Sulfur Clusters. J. Barton. Caltech. 4:30 A Role for Underlying Glycan Structure in 4:30 New Insight Into the Role of ATP in Iron Influenza Binding: Extending the Species Specificity Paradigm. Sulfur Cluster Scaffolding by the Mrp/Nbp35 Family of Cluster R.J. Woods, O.C. Grant, J.A. Hadden, H.M.K. Smith, W. Peng, Scaffolds. D.L. Perlstein, J. Grossman. Boston Univ. (608.5) R. De Vries, R. McBride, J.C. Paulson. Univ. of Georgia, Natl. 4:45 112.2 Biosynthesis of the FeFe Hydrogenase Active Univ. of Ireland, Galway, Univ. of Illinois at Urbana-Champaign Site. D.L.M. Suess, R.D. Britt. Univ. of California, Davis. and The Scripps Res. Inst. (1103.6) 5:10 A Surprising Shift in the Biosynthesis of Marine 4:45 114.2 Toward a Functional, ChemoProteomic Meroterpenoids. Z. Miles, S. Deithelm, J. George, B. Moore. Interrogation of Kinome and Nucleotide Binding Space. J.W. UCSD and Univ. of Adelaide. (608.4) Kozarich. ActivX Biosciences, La Joll. 5:25 New Function of Enzyme Involved in the 5:10 De Novo Synthesis from Tryptophan in Formation of a Carbon-Nitrogen Triple Bond. M. Kobayashi. the Absence of a QPRTase Homolog Contributes to NAD+ Grad. Sch. of Life and Envrn. Sci., Univ. of Tsukuba. (1084.1) Biosynthesis in C. elegans. M.R. McReynolds, W. Wang, L. 5:40 112.3 Exploring the Mechanistic Diversity of Holleran, W. Hanna-Rose. Penn State. (849.1) Non-heme-Iron Enzymes by Freeze-Quench Mössbauer 5:25 Mitochondrial Protein Functions Revealed by Spectroscopy. C. Krebs, J.M. Bollinger; Jr. Penn State. Global Protein-Lipid-Metabolite Profiles. D.J. Pagliarini, J.A. 6:05 Discussion. Stefely, N. Kwiecien, A. Hebert, M. Veling, A. Richards, A. Ulbrich, A. Jochem, M. Rush, E. Freiburger, H. Marx, M. Westphall, J. Coon. Morgridge Inst. for Res. and Univ. of Wisconsin-Madison. (1100.4)

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5:40 114.3 Lipidomics in Disease and Drug Discovery. 4:30 Innovative Program That Broadens Career E.A. Dennis. UCSD. Development Training through Community Partnerships and 6:05 Discussion. Outreach. T.M. Evans. Grad. Sch. of Biomed., Sci., Univ. of Texas Hlth. Sci. Ctr. at San Antonio. (663.1) 115. MEMBRANE CONTACT SITES AND 4:45 116.2 Lessons Learned from the Broadening LIPID TRAFFICKING Experiences in Scientific Training (BEST) Awards. P. Labosky. OSC, NIH. Symposium 5:10 Analysis of NIEHS Postdoctoral Alumni Career Outcomes. T.R.L. Collins, R. Gilliam, S. Peddada, H. Xu. Sun. 4:00 pm—San Diego Convention Center, Room 6F NIEHS, NIH, Durham, NC. (883.2) 5:25 Changing Career Prospects Are Changing the Chaired: T. Walther Needs in Graduate and Postdoc Training. S.E. Feeney. Univ. Follow the conversation: #lipids of California, Davis. (663.3) S 5:40 116.3 NIH/IRACDA Program – A Win for Both U 4:00 Chair’s Introduction. Postdocs and PUI Partner Institutions. M.A. Carroll, N 4:05 115.1 Broadband Connections within the Cell: E.J. Catapane, M. Soto, G. Brewer. Medgar Evers Col./ How Mitochondria Talk to the Endomembrane. B. Kornman. CUNY, Brooklyn and Rutgers-Robert Wood Johnson Med. ETH Zurich. Sch., Piscataway. 4:30 An EE-Golgi Tether Facilitates Ceramide 6:05 Discussion. Transfer Out of the ER and Alleviates Ceramide Toxicity. L-K. Liu, A. Toulmay, W. Prinz. NIDDK, NIH. (660.1) 4:45 115.2 Extended-Synaptotagmins as Lipid 118. CRISPR: POWER AND CHALLENGES Transporters at ER-PM Contact Sites. K.M. Reinisch, C. Schauder, X. Wu, Y. Saheki, P. Narayanaswamy, F. Torta, M. Workshop Wenk, P. De Camilli. Yale Univ. Sch. of Med., Natl. Univ. of Sun. 6:30 pm—San Diego Convention Center, Room 6A Singapore and HHMI, New Haven, CT. 5:10 Phosphatidylserine Production at Membrane Follow the conversation: # Contacts Sites Enhances Its Transport Out of the Endoplasmic 6:30 118.1 CRISPR-Cas9: Power and Challenges. Reticulum. M. Kannan, S. Lahiri, L-K. Liu, W.A. Prinz. NIDDK, E. Charpentier. Max Planck Inst. for Infect. Biol., Berlin, NIH and Univ. of Virginia. (660.2) Helmholtz Ctr. for Infect. Res., Germany, Umeå Univ., Sweden 5:25 A Conserved Family of Proteins Facilitates and Hannover Med. Sch., Germany. Nascent Lipid Droplet Budding from the ER. V. Choudhary, N. 6:30 118.2 The Asymmetric Interaction of Cas9 with Ojha, A. Golden, W.A. Prinz. NIDDK, NIH. (1132.1) Target DNA Can Promote High Efficiency Homology-Directed 5:40 115.3 ER-Plasma Membrane Contact Sites Regulate Genome Editing. J.E. Corn, C.D. Richardson, J. Ray, G. Sterol Import in Yeast. A. Menon, Y.Y. Sere, J. Johansen, E. Curie, M. DeWitt. Univ. of California, Berkeley. Quon, N. Chauhan, C.T. Beh. Weill Cornell Med. Col. and 6:30 118.3 Globally Monitoring Protein Synthesis Simon Fraser Univ., Canada. in Time and Space hrough Ribosome Profiling. 6:05 Discussion. J. Weissman. UCSF/HHMI.

116. INTEGRATING COMPLEMENTARY SKILLS INTO 119. WELCOME RECEPTION SPONSORED BY THE GRADUATE AND POSTDOC TRAINING ASBMB MINORITY AFFAIRS COMMITTEE

Symposium Special Event

(Sponsored by: ASBMB Education and Professional Sun. 7:30 pm—San Diego Marriott Marquis & Marina Development Committee) Hotel, Marina Ballroom D Sun. 4:00 pm—San Diego Convention Center, Room 14A A professional networking event featuring ASBMB Graduate

Chaired: S.H. Oyewole Student Travel Award research posters. ASBMB members and biochemistry registrants welcome. Follow the conversation: #education 4:00 Chair’s Introduction. 4:05 116.1 Individual Development Plans: Determining Your Strengths, Identifying Areas for Improvement, and Initiating Conversations about Your Career. Y.R. Seger. Ofc. of Are You Tweeting about Publ. Affairs, FASEB. EB 2016? To Tweet use #expbio

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41 NUTRITION SUNDAY Nutrition

120. ASN SPONSORED SATELLITE PROGRAM: 123. DELIVERING NUTRITION INTERVENTIONS BACK TO THE FUTURE? ANCIENT GRAINS AND TO WOMEN DURING PREGNANCY: SPROUTING FOR ENHANCED NUTRITION BEYOND INDIVIDUAL INTERVENTIONS TO COMPREHENSIVE ANTENATAL GUIDELINES ASN Satellite AND CARE (Organized and Sponsored by: The Kellogg Company) Symposium Sun. 6:30 am—San Diego Convention Center, Room 33BC Sun. 8:00 am—San Diego Convention Center, Room 31ABC For more information on ASN Sponsored Satellite Programs, please visit http://scientificsessions.nutrition.org/ (Sponsored by: Global Nutrition Council) satellitesessions/. (Cosponsored by: L.M. De-Regil)

Chaired: R.J. Stoltzfus 121. NUTRITIONAL EPIDEMIOLOGY RIS BUSINESS MEETING, MIXER AND MENTORING EVENT Cochaired: L.M. De-Regil Global and Community Nutrition Sun. 7:00 am—Hilton San Diego Bayfront, Indigo C 8:00 Introduction. R.J. Stoltzfus. Cornell Univ. 8:10 Nutrition in Antenatal Care: History and Current 122. OPTIMIZING THE AGING BRAIN Guidance. E. Phillips. Independent Consultant. THROUGH NUTRITION 8:35 Experiences, Options and Challenges of Delivering Exclusive Breastfeeding Counseling in Pregnancy. Symposium M. Mbuya. Zvitambo Inst. for Maternal Child Hlth. 9:00 Experiences, Options and Challenges of Delivering Sun. 8:00 am—San Diego Convention Center, Micronutient Interventions in Pregnancy. K. Dickin. Ballroom 20D Cornell Univ. Chaired: S.N. Meydani 9:25 An Integrative Research Agenda: Health Systems Strengthening and Integrating Nutrition into ANC. Cochaired: N. Surzenko C. Taylor. Management Sci. for Hlth. (Nutrition Across the Lifespan: From Pediatrics to Geriatrics 124. EXPERIMENTAL ANIMAL NUTRITION: ANIMAL MODELS FOR NUTRITION ACROSS 8:00 The Aging Brain: Current Knowledge and Future PHYSIOLOGICAL STATES Possibilities. D. Steindler. Jean Mayer USDA HNRC on Aging at Tufts Univ. Minisymposium 8:25 Nutrients, Cognitive Development and the Potential of Personalized Nutrition. S. Zeisel. Univ. of North (Sponsored by: Experimental Animal Nutrition RIS) Carolina at Chapel Hill. Sun. 8:00 am—San Diego Convention Center, Room 33A 8:50 Diet and Cognitive Function: What Works and How Do we Measure It? A. Scholey. Swinburne Univ. Chaired: C.L. Levesque 9:15 Nutrients and the Aging Brain: Insights from Studies with Nutrients, Brain Injuiry and Imaging Techniques. Cochaired: K.M. Ajuwon A. Barbey. Beckman Inst. for Advanced Sci. and 8:00 124.1 Enriching the Maternal Diet in Long Chain Technol. at the Univ. of Illinois. n-3 Polyunsaturated Fatty Acids Alters Lipid Metabolites and 9:40 Panel Discussion. D. Klurfeld. USDA, Beltsville. Adiposity in Broiler Chicks. R. Beckford, S. Howard, S. Das, A. Tester, S. Campagna, J. Whelan, J. Wilson, B. Voy. Univ. of Tennessee, Knoxville and Univ. of Georgia. 8:15 124.2 Maternal Vitamin A Supplementation Expands Adipose Progenitor Population through Promoting Vascular Development. B. Wang, X. Fu, S. Zhang, X. Liang, M. Zhu, M. Visit the Exhibits Du. Washington State Univ. 8:30 124.3 Long-Term Leucine and BCAA Inclusion in a April 3–April 5 30% Protein and Energy Restricted Diet Increases mTORC1 Signaling in Skeletal Muscle of Neonatal Pigs. R. Manjarin, Exhibit Hours D.A. Columbus, J. Solis, A. Suryawan, A.D. Hernández- García, H.V. Nguyen, M.L. Fiorotto, T. Davis. Baylor Col. of Sunday–Tuesday Med. and Cal Polytech State Univ., San Luis Obispo. 9:00 AM–4:00 PM

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8:45 124.4 Resveratrol Consumption and RIP140 9:30 125.7 Early Intervention with Dietary Fish Oil, Flax Knockout Mice Demonstrate a Novel Relationship between Oil and Soy Protein in Three Orthologous Rodent Models of Increased Mitochondrial Content and Compromised Bone Human Hereditary Polycystic Kidney Disease. J.G. Devassy, T. Mineral Mass, Microarchitecture, and Strength. P.M. Miotto, Yamaguchi, Md. Monirujjaman, M. Gabbs, M. Morrish, H.M. S. Frendo-Cumbo, S.M. Sacco, D.C. Wright, W.E. Ward, G.P. Aukema. Univ. of Manitoba, St Boniface Hosp. Res. Ctr. and Holloway. Univ. of Guelph and Brock Univ., Canada. Manitoba Inst. of Child Hlth., Winnipeg. 9:00 124.5 Pigs Fed a Western Diet Develop Elevated 9:45 125.8 The Effect of Wheat Peptides on Ethanol- Fasting Glucose and a Microbiome Analogous to Human Induced Gastric Mucosal Damage in Rats. X. Yang, G. Sun, S. Obesity. K. Hintze, L. Cox, M. Lefevre, S.C. Isom. Utah Wang. Sch. of Publ. Hlth., Southeast Univ., China. State Univ. 9:15 124.6 Soluble and Insoluble Fiber Differentially 126. OBESITY: CHRONIC DISEASE Impact Canine Fecal Microbiome and Circulating Metabolome. S M.I. Jackson, D.E. Jewell. Hill’s Pet Nutr., Topeka. Minisymposium 9:30 124.7 Do Standard Laboratory Practices Lead to U Obese Zebrafish Populations? S.A. Watts, L. Dennis, L.A. (Sponsored by: Obesity RIS) N Fowler, M.B. Williams, Y. Yuan, R.J. Barry, S. Farmer, L.R. Sun. 8:00 am—San Diego Convention Center, Room 29B D’Abramo, M.L. Powell. Univ. of Alabama at Birmingham. 9:45 124.8 Effects of Food Matrix and Western Diet on Chaired: A. Brown Colorectal Cancer and Metabolism in C57BL/6 Mice. K. Hintze, 8:00 126.1 Echocardiography Evaluation as a Marker T. Hisatome, S. Kellen, R. Ward, A. Benninghoff, M. Lefevre. of Cardiovascular Risk on Obese Children and Adolescents. Utah State Univ. C.A. Nogueira-de-Almeida, S.H. Caixe, A.C.G.S. Benedeti, J. Garcia. Univ. of Ribeirão Preto and UNAERP/Fatesa, 125. DBC: BIOACTIVE DIETARY PROTEINS Ribeirão Preto, Brazil. 8:15 126.2 Effect of Salba-Chia (Salvia hispanica L), an Minisymposium Ancient Seed, in the Treatment of Overweight and Obese (Sponsored by: Dietary Bioactive Components RIS) Patients with Type 2 Diabetes: A Double-Blind, Parallel, Randomized Controlled Trial. A.L. Jenkins, C. Brissette, Sun. 8:00 am—San Diego Convention Center, Room 29A E. Jovanovski, F. Au-Yeung, H.V.T. Ho, A. Zurbau, J. Sievenpiper, V. Vuksan. St. Michael’s Hosp., Toronto, Univ. of Chaired: E. deMejia Toronto and Li Ka Shing Knowledge Inst.,Toronto. 8:00 125.1 Identification of Glycoproteins on the8:30 126.3 A Systematic Examination of the Association Surface of Cow’s Milk Exosomes That Mediate the Uptake between Parental and Child Obesity: Systematic Review and of Exosomes into Human Colon Carcinoma Caco-2 Cells. Meta-analysis. Y. Wang, J. Min, J. Khuri, M. Li. Sch. of Publ. S. Sukreet, H. Zhang, J. Adamec, J. Cui, J. Zempleni. Univ. Hlth. and Hlth. Professions, Univ at Buffalo SUNY. of Nebraska-Lincoln. 8:45 126.4 Therapeutic Potential of AICAR in Attenuating 8:15 125.2 Replacing Pork and Chicken with Herring Obesity-Induced Metabolic, Liver and Kidney Disease. (Clupea harengus) Increases Plasma Glucosamine and E. Borgeson, V.W. Borgeson, C. Godson, K. Sharma. Decreases Carbon Flux through the Citric Acid Cycle in Univ. of Gothenburg, Sweden, University Col. Dublin, Ireland Overweight Men and Women. A. Ross, A. Vincent, O. and UCSD. Savolainen, H. Lindqvist, M.V. Lind, A-S. Sandberg. 9:00 126.5 Berberine Ameliorates Hepatic Steatosis and Chalmers Univ. of Technol. and Gothenburg Univ., Sweden. Suppresses Liver and Adipose Tissue Inflammation in Obesity 8:30 125.3 Long-Term Feeding of a Soy-Protein-Based Mice Independent of AMPK. S-L. Woo, T. Guo, X. Guo, H. Li, Diet Improves Trabecular and Cortical Bone Outcomes in Low- J. Zheng, R. Botchlett, Y. Cai, X. Li, Q. Li, X. Xiao, Y. Huo, C. Fit, Intact and Ovariectomized Female Rats. M.W. Richard, Wu. Texas A&M Univ., Hubei Hosp. of Chinese Med., Wuhan, L.C. Ortinau, T.M. Zidon, P.S. Hinton, V. Vieira-Potter. Univ. The First Hosp. of CMU, China and Georgia Regents Univ. of Missouri-Columbia. 9:15 126.6 Delta-Tocotrienol Regulates Lipid Metabolism 8:45 125.4 Modulation of Cerebral Activity Induced by in Livers of High Fat Fed Mice. L. Ramalingam, L. Allen, S. α-Casozepine, a Benzodiazepine-Like Peptide Derived from Scoggin, K. Gurvinder, M.D. Tomison, C-L. Shen, E. Chung, Bovine Casein. S. Benoit, C. Chaumontet, Cakir-Kiefer, D. J. Dufour, N. Moustaid-Moussa. Texas Tech Univ. and Texas Tomé, L. Miclo. AgroParisTech, INRA, Univ. Paris-Saclay and Tech Hlth. Sci. Ctr. Univ. de Lorraine-Nancy, France. 9:30 126.7 Secretory Factors Produced by Stromal 9:00 125.5 Collagen Peptides Derived from Alaska Cultures of Human Omental Adipose Tissue Inhibit Adipose Pollock Skin Protect against TNFα-Induced Dysfunction of Differentiation. R.T. Pickering, M-J. Lee, M. Jager, M. Layne, Tight Junctions in Caco-2 Cells. Q. Chen, B. Li, I. Martin, J.B. S.K. Fried. Boston Univ. Sch. of Med. Blumberg, C-Y.O. Chen. Ocean Univ. of China, USDA at Tufts 9:45 126.8 Obesity Prevention by Calorie Restraint Univ. and State Univ. of Campinas, Brazil. Using the Bathroom Scale Model Prevents Hypertension for 9:15 125.6 Antidiabetic Effect of Black Bean Peptides Life in Nonhuman Primates. B.C. Hansen, E.H. Linden, J.D. through Reduction of Glucose Absorption and Modulation of Newcomb. Univ. of South Florida Morsani Col. of Med. SGLT1, GLUT2 and DPP-IV in In Vitro and In Vivo Models. L. Mojica, E.G. DE MEJIA, M. Menjivar, M. Granados-Silvestre. Univ. of Illinois, Urbana and UNAM, Mexico City.

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127. NUTRIENT-GENE INTERACTIONS: GENOMICS, 8:15 128.2 1,25-Dihydroxyvitamin D Regulates Energy PROTEOMICS, AND METABOLOMICS Substrate Metabolism to Reduce Triacylglycerol Accumulation in 3T3-L1 Adipocytes. B.M. Larrick, K-H. Kim, S.S. Donkin, D. Minisymposium Teegarden. Purdue Univ. 8:30 128.3 Body Mass Index Is a Strong Predictor of (Sponsored by: Nutrient-Gene Interactions RIS) Low Serum 25(OH)D Levels in Multiethnic Obese Children Sun. 8:00 am—San Diego Convention Center, Room 29C in Western Massachusetts. S. Kannan, P. Visintainer, H.B. Ganguri, C. Wittcopp. So. Illinois Univ. Carbondale, Tufts Chaired: T.T. Wang Univ. Sch. of Med., Baystate Med. Ctr., Springfield, MA and Kronsys, Raleigh, NC. 8:00 127.1 Depletion of Dietary MicroRNAs from Cow’s 8:45 128.4 Placental Megalin and Cubilin Expression Is Milk Causes an Increase of Purine Metabolites in Human Associated with Markers of Vitamin D Status but Not Fetal Body Fluids and Mouse Livers. A.G. Aguilar Lozano, S. Bone Growth during Adolescent Pregnancy. C.M. Whisner, Baier, J. Adamec, M. Sadri, D. Giraud, J. Zempleni. Univ. C.E. Thomas, K.O. O’Brien. Sch. of Nutr. and Hlth. Promotion, of Nebraska-Lincoln. Arizona State Univ. and Cornell Univ. 8:15 127.2 Gene, Sex and Diet Interact to Control the 9:00 128.5 Urinary -CEHC Predicts -Tocopherol Status Tissue Metabolome. A. Wells, W. Barrington, D. Threadgill, S. α α in Healthy Adults and Those with Metabolic Syndrome. M.G. Dearth, S. Campagna, A. Saxton, B. Voy. Univ. of Tennessee Traber, S.W. Leonard, E. Mah, G. Bobe, R.S. Bruno. Oregon and Texas A&M Univ. State Univ., The Ohio State Univ. and Biofortis Clin. Res., 8:30 127.3 A Genome-Wide Association Study of Plasma Addison, IL. α -Macroglobulin Concentrations in Young Adults. J. Jamnik, 2 9:15 128.6 Development of a Model for In Vitro C. Borchers, A. El-Sohemy. Univ. of Toronto and Univ. of Comparative Absorption of Magnesium from Five Magnesium Victoria, Canada. Sources Commonly Used as Dietary Supplements. J.W. Hartle, 8:45 127.4 Genetic Influence on Xanthine Oxidase Activity S. Morgan, T. Poulsen. Albion, UT. and Arginine Metabolites in Hispanic Children. V.S. Voruganti, 9:30 128.7 Assessing the Relationship of Vitamin D with G. Chittoor, K. Haack, S. Laston, I. Vazquez-Vidal, N.R. Iron Status in Children with Inflammatory Bowel Disease. Mehta, A.G. Comuzzie, S.A. Cole, N.F. Butte. Univ. of North S. Syed, E.M. Smith, V. Tangpricha, S. Chesdachai, A. Carolina at Chapel Hill, Kannapolis, Texas Biomed. Res. Inst., Kumar, J. Prince, T.R. Ziegler, P.S. Suchdev, S. Kugathasan. San Antonio, Univ. of Texas at Rio Grande Valley and Baylor Emory Univ. Col. of Med. 9:45 128.8 Effects of Whole Egg Consumption on Vitamin 9:00 127.5 Interaction between PhIP from Meat Intake E Absorption from Co-consumed, Mixed-Vegetable Salad. and Polymorphism in Superoxide Dismutase 2 Gene Increases J.E. Kim, M.G. Ferruzzi, W.W. Campbell. Purdue Univ. Risk of Oxidative Stress. A. Carvalho, J. Steluti, A.A. Carioca, A.P. Loureiro, G. Gattas, R. Fisberg, D. Marchioni. Univ. of São Paulo. 129. COMMUNITY AND PUBLIC HEALTH NUTRITION: 9:15 127.6 LCT Gene Variant -13910 CT Genotype and Plasma 25-Hydroxyvitamin D with Premenstrual Cochaired: S. Colby Symptoms. A.C. Jarosz, O. Alharbi, A. El-Sohemy. Univ. of Toronto. 8:00 129.1 Assessment of Home Food Environment among Healthy Weight and Overweight/Obese School-Age 128. VITMIN: WATER AND FAT SOLUBLE VITAMINS Children. M.J. Nepper, W. Chai. Univ. of Nebraska-Lincoln. 8:15 129.2 The Impact of Neighborhood Food Environment AND CHRONIC DISEASE, MICRONUTRIENT on School Meal Participation Rates. N. Vaudrin, P. Ohri- BIOVAILABILITY AND ANTIOXIDANT FUNCTION Vachaspati, J. Green, C. Lorts, M. Yedidia. Sch. of Nutr. And Hlth. Promotion, Arizona State Univ. and Rutgers Univ. Minisymposium 8:30 129.3 Availability and Price of Fruits and Vegetables (Sponsored by: Vitamins and Minerals RIS) at Food Retailers in Western Massachusetts Counties. Q. Jiang, J. Burdick, J. Chaiken, S. Walsh, N. Cohen. Univ. of Sun. 8:00 am—San Diego Convention Center, Room 29D Massachusetts Amherst. Chaired: J. Finkelstein 8:45 129.4 It’s Not How Much Your Spend, It’s Where You Spend It: How Consumer Behavior Predicts Dietary Energy Cochaired: S. Ajabshir Density. A. Massedge, J.A. Vernarelli. Fairfield Univ. 9:00 129.5 A More Efficient Method of Assessing Corner 8:00 128.1 The Role of Vitamin D in Obesity and Diabetes: Store Healthfulness. R. DeWeese, M. Todd, A. Karpyn, M. Ca2+ Signaling, Insulin Secretion, Adipocyte Apoptosis, and Yedidia, M. Kennedy, M. Bruening, C. Wharton, P. Ohri- Bone Mineralization. I.N. Sergeev. South Dakota State Univ. Vachaspati. Arizona State Univ., Univ. of Delaware and Rutgers Univ.

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9:15 129.6 What Do Parents and Children Talk about While 131. NUTRITION TRANSLATION: NUTRITION Grocery Shopping? A Content Analysis of Shopping Trips. AND FOOD SCIENCE FOR PUBLIC POLICY, E. Calloway, A. Pritchard, C. Roberts-Gray, S. Sweitzer, PRACTICE AND THE CONSUMER M. Briley. Gretchen Swanson Ctr. for Nutr., Omaha, Univ. of Texas at Austin and Third Coast Res., Galveston. Minisymposium 9:30 129.7 Comparison of Food Availability in School Stores in Seoul, South Korea before and after Implementation (Sponsored by: Nutrition Translation RIS) of Two National Food- and Nutrient-Based Policies. S.K. Choi, Sun. 8:00 am—San Diego Convention Center, Room 30C E.A. Frongillo, C.E. Blake, J.F. Thrasher. Arnold Sch. of Publ. Hlth., Univ. of South Carolina. Chaired: L. Sanders 9:45 129.8 A Novel Approach for Determining the Cochaired: E. Glynn Environmental Impacts of Individual Food Choices in the United S States. D. Rose, M. Heller, A. Willits-Smith, A.R. Mundorf, 8:00 131.1 Does the Left Hand Know What the Right Hand G. Keoleian. Tulane Univ. and Univ. of Michigan. Is Doing? Part I: Alignment between the AFRI Foundational U Function and Efficacy of Nutrients Program and the 2010 N 130. ENERGY AND MACRONUTRIENT METABOLISM: Dietary Guidelines. M.M. Koeninga, K. Krishnan, C. Perez, DIETARY FATTY ACIDS AND HEALTH D.N. Chester. Natl. Inst. of Food and Agr., Washington, DC and Texas A&M, Bryan. Minisymposium 8:15 131.2 Advancing Systematic Review Methodology to Better Inform Food and Nutrition Policy. T.L. Psota, M. Spill, (Sponsored by: Energy & Macronutrient Metabolism RIS) J. Spahn, D. Gungor, K. Johns, P. Nadaud, Y.P. Wong, E. Sun. 8:00 am—San Diego Convention Center, Room 30B Essery Stoody, C. Rihane. USDA, Alexandria, VA. 8:30 131.3 Adherence to the 2015 Dietary Guidelines for 8:00 130.1 DHA Is More Potent Than EPA in Attenuating Americans and Risk of Healthy and Unhealthy Obesity among Cardiometabolic Risk in Men and Women: A Randomized Canadian Adults. M. Jessri, W. Lou, M. L’Abbe. Dalla Lana Double-Blind, Placebo-Controlled Crossover Trial. J. Allaire, Sch. of Publ. Hlth., Univ. of Toronto. P. Couture, A. Charest, M. Leclerc, J. Marin, M-C. Lépine, A. 8:45 131.4 Foods Consumed from Non-school Cafeterias Tchernof, B. Lamarche. Univ. Laval and Univ. Inst. of Cardiol. and Vending Machines: NHANES 2006-2012. S.J. Onufrak. and Pneumol. of Québec. Ctrs. for Dis. Control and Prevent. 8:15 130.2 Assessing the Role of Saturated Fats in 9:00 131.5 Children Are Eating Savory Snack Foods: What Adipose Tissue Inflammation. M. Morgan-Bathke, W. Faubion, We Eat in America, NHANES 2011-2012. D.G. Rhodes, J.C. M. Jensen. Mayo Clin. and Viterbo Univ., WI. Clemens, M.A. Hymes, A.J. Moshfegh. USDA, Beltsville, MD. 8:30 130.3 Effect of Omega-3 Polyunsaturated Fatty Acids 9:15 131.6 Nutrient Profiling for the reformulation of on Insulin Resistance Are Sex-Dependent: A Meta-Analysis of Pizza: Modelled Impact on Nutritional Intake in the U.S. Adult Randomized Controlled Trials. M.L. Garg, K. Abbott, R. Thota, Population. G. Masset, A. Vlassopoulos, U. Lehmann. Nestlé S. Acharya, T.L. Burrows. Univ. of Newcastle, Wallsend Res. Ctr., Lausanne. and Callaghan and NSW Dept. of Hlth., New Lambton 9:30 131.7 Are Foods of Higher Nutritional Quality More Hgts., Australia. Expensive Than Their Less Healthy Counterparts? An Analysis 8:45 130.4 Short-Chain Fatty Acids, 4-Phenylbutyric Acid and of Canadian Packaged Foods. M-E. Labonté, S. Noorhosseini, R-Alpha-Lipoic Acid, Improve mTORC1-Driven Overproduction of J. Bernstein, M. Ahmed, M. L’Abbé. Univ. of Toronto. apoB-Containing Triacylglyceride-Rich Lipoproteins. R. Moreau, 9:45 131.8 Mapping Inflammation and Cancer-Modifying J.L. Roberts, B. He, A. Erickson. Univ. of Nebraska-Lincoln. Regions in Broccoli Genome. W. Bussler, J. Alley, H. Chandler, 9:00 130.5 Effects of Corn Oil, Compared to Extra Virgin C. Thetford, G. Yousef, A. Brown, D. Esposito, M.A. Lila, S. Olive Oil, Intake on Lipoprotein and Subfraction Cholesterol Komarnytsky. North Carolina State Univ., Kannapolis and Levels in Men and Women: Results from a Randomized, Raleigh, Iowa State Univ. and Catawba Col., NC. Controlled Feeding Study. K.C. Maki, A.L. Lawless, K.M. Kelley, V.N. Kaden, C.J. Geiger, O.M. Palacios, M.R. Dicklin. 132. INNOVATIONS IN UNDERGRADUATE, Midwest Ctr. for Metab. & Cardiovasc. Res., Glen Ellyn, IL, Biofortis Innovation Svcs./Merieux NutriSci., Addison, IL and GRADUATE AND MEDICAL Geiger & Assocs. LLC, Fort Bridger, WY. NUTRITION EDUCATION 9:15 130.6 Obesity and Dietary Fat Modulate HDL Function in Adolescents: Results from a Cross-Sectional Minisymposium Analysis and a Randomized, Placebo-Controlled, Crossover Assoc. of Nutrition Departments and Programs Trial. A.M. McMorrow, M. O’Reilly, R.M. Connaughton, E. Carolan, D. O’Shea, F.E. Lithander, F.C. McGillicuddy, H.M. Sun. 8:00 am—San Diego Convention Center, Room 30D Roche. University Col. Dublin, St Vincent’s Univ. Hosp., Dublin Chaired: M.L. Dunn and Univ. of Canberra. 9:30 130.7 Dietary Linoleic Acid Increases Linoleic- and 8:00 132.1 Spicing Up Introductory Nutrition. Arachidonic Acid-Derived Bioactive Lipids, Despite Not Altering D.A. Levitsky. Cornell Univ. Tissue Fatty Acid Levels. S.M. Leng, H.M. Aukema. Univ. of 8:15 132.2 University Nutrition Programs– Training Manitoba and CCARM, Winnipeg. Students for Careers beyond Dietetics: Reflections from an 9:45 130.8 Effect of Plant Sources of Omega-3 PUFA on Established, Emerging, and New Program. H.J. Willis, M.L. Mood Status in Healthy Subjects: A Crossover Feeding Trial. Stewart, D.E. Smith. St. Catherine Univ., Univ. of Hawaii at W.M. Young. Loma Linda Univ. Manoa and Univ. of Minnesota, St. Paul.

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8:30 132.3 Managing the Growing Classroom: 133. OPENING SESSION AND DISCUSSION: Opportunities for Postdoctoral Teaching Fellows. J.E.H. Nevins, SCIENTIFIC RIGOR IN THE NUTRITION A.L. Wilkinson. Cornell Univ. RESEARCH LANDSCAPE 8:45 132.4 Reinforcing Nutrition and Core Science Fundamentals through a Multi-semester Research Project. Special Session W.A. Clark, M.E. Johnson. East Tennessee State Univ. 9:00 132.5 Development and Evaluation of the (Sponsored by: ASN, Canadian Nutrition Society, ILSI Transdisciplinary Obesity Prevention Research Sciences North American and the Institute of Medicine.) Program. D. Teegarden, J. Bowers, A. Hammons, L. Sun. 10:30 am—San Diego Convention Center, Destefano, G. Garcia, B. Koester, L. Parker, A. Childress, B. Ballroom 20D Fiese. Purdue Univ., Univ. of Illinois at Urbana-Champaign and California State Univ., Fresno. Chaired: P.J. Stover 9:15 132.6 Innovations in Course Design to Facilitate Understanding, Retention, and Application of Regulation of Macronutrient Metabolism. A. Thalacker-Mercer, R. Vanderlan. 134. OMICS APPLICATIONS IN Cornell Univ. METABOLIC PHYSIOLOGY 9:30 132.7 The Impact of Linking Immigrants with Nutrition Knowledge Initiative on Improving Cultural Competency Symposium Skills among Nutrition and Dietetic Students in Canada. (Cosponsored by: The American Physiological Society) H. Vatanparast, C. Henry, S. Mulhall. Univ. of Saskatchewan. 9:45 132.8 A New Model for Incorporating Nutrition Into the Sun. 10:30 am—San Diego Convention Center, Room 25B Medical School Curriculum. M. Yakub, G. Al-Eyd, H. Atamna, Chaired: S.H. Adams D. Atapattu, L. Castro, J. Estrada, S. Lakhan, F. Nausheen, T. Seki, A. Tenore, A. Velji, R. Suskind. California Univ. of Sci. Cochaired: M. Olfert and Med., Col. of Med. Cellular and Molecular Nutrition 268. INTERNATIONAL FORUM – TAIWAN 10:30 Metabolomics and the Physiology of Exercise and Insulin Resistance. S. Adams. Univ. of Arkansas for International Forum Med. Sci. (Supported by The Nutrition Society of Taiwan ) 11:00 The Sphingolipidome and Insulin Resistance: Perspectives Gained from Studying the Overweight (Organized and Sponsored by: The Nutrition Society Dairy Cow Transitioning From Gestation to Lactation. of Taiwan) J. McFadden. West Virginia Univ. 11:30 Genes, Exercise and Angiogenesis: Implications for the Mon. 8:30 am—San Diego Convention Center, Room 32AB Metabolome. M. Olfert. West Virginia Sch. of Med. Chaired: F-Y. Tang 12:00 Metabolic Processes and Physiological Parameters Involved with the Ischemia/Reperfusion Protective Cochaired: E-P.I. Chiang Phenotype in Hibernators. L. Bogren. Univ. of This session will introduce the research interests and the Colorado Anschutz Med. Campus, Aurora. national nutrition survey of B vitamins in Taiwan. In addition, the 12:15 Depletion of Dietary MicroRNAs from Cow’s Milk Causes organizers will provide a platform for the exchange of information an Increase of Purine Metabolites in Human Body and the promotion of international collaboration and cooperation Fluids and Mouse Livers. A.G. Aguilar Lozano, S. in nutrition research for scientists, dieticians, education Baier, J. Adamec, M. Sadri, D. Giraud, J. Zempleni. professionals, investigators and industry. Univ. of Nebraska-Lincoln. (127.1)

8:30 Thiamin and Riboflavin Status in Taiwan and our Coping 135. ASN SPONSORED SATELLITE PROGRAM: Strategy. F.L. Yang. Fu Jen Catholic Univ., Taiwan. DIETARY PROTEIN: CURRENT PERSPECTIVES 8:50 Vitamin B-6 and Homocysteine with Inflammation and Oxidative Stress in Certain Diseases. Y-C. Huang. ASN Satellite Chung Shan Med. Univ. 9:10 1-Carbon Metabolic Kinetics in Human Disease Models. (Organized and Sponsored by: PepsiCo) E-P. Chiang. Natl. Chung Hsing Univ. Sun. 12:45 pm—San Diego Convention Center, Room 33BC 9:30 Taiwan Folate Nutrition in Cancer Co-therapeutic Medicine: From Basic Research to Public Health and For more information on ASN Sponsored Satellite Clinical Application. R-F. Huang. Fu Jen Catholic Programs, please visit http://scientificsessions.nutrition.org/ Univ., Taiwan. satellitesessions/. 9:50 Discussion.

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136. NUTRIENT-GENE INTERACTION RIS BUSINESS 140. FOOD SYSTEMS FOR PUBLIC HEALTH: MEETING AND SCIENTIFIC DISCUSSION: ASSESSMENT, IMPACT AND IMPLICATIONS OF BIOMARKERS DEFINED MEETING FRUIT AND VEGETABLE CONSUMPTION RECOMMENDATIONS ON ENVIRONMENTAL, RIS Forum ECONOMIC AND AGRICULTURAL SUSTAINABILITY (Sponsored by: Nutrient-Gene Interaction RIS) Symposium Sun. 12:45 pm—San Diego Convention Center, Room 33A Sun. 3:00 pm—San Diego Convention Center, Chaired: T.T. Wang Ballroom 20D

Chaired: J.W. Finley 137. ASN SPONSORED SATELLITE PROGRAM: S Cochaired: J.R. Mein NEW FRONTIERS IN FIBERS: INNOVATIVE U TECHNOLOGY AND EMERGING RESEARCH ON Global and Community Nutrition N GUT MICROBIOME AND BONE HEALTH 3:00 The Challenge of Feeding Nine Billion. D. Dimick. Natl. Geographic Soc. ASN Satellite 3:20 Modelling the Impact of Increasing Fruit and Vegetable (Organized and Sponsored by: Tate & Lyle) Consumption on the U.S. Agricultural System. E. Marshall. USDA Economic Res. Svc. Sun. 12:45 pm—San Diego Convention Center, Room 32AB 3:40 Climate Change and Water Resource Impacts on For more information on ASN Sponsored Satellite US Fruits and Vegetables. C. Rosenzweig. NASA Programs, please visit http://scientificsessions.nutrition.org/ Goddard Inst. for Space Studies. satellitesessions/. 4:00 Changing Consumption/Demand for Vegetables with Breeding/Decreasing Post-harvest Loss. J. Mein. . 138. VITAMINS AND MINERALS RIS BUSINESS MEETING 4:20 Achieving Sustainable Nutrition Security: The Essential AND OUTSTANDING RESEARCHER SHOWCASE Role of Partnerships. D. Gustafson. ILSI Res. Fndn.

RIS Forum 141. HERITABLE FACTORS AND COMPLEX (Sponsored by: Vitamins and Minerals RIS) DISEASES: USING GENETIC EPIDEMIOLOGY TO DRAW INFERENCES ABOUT NUTRITION- Sun. 1:00 pm—San Diego Convention Center, Room 28DE DISEASE RELATIONSHIPS Chaired: L. Tussing-Humphreys Symposium

Sun. 3:00 pm—San Diego Convention Center, Room 31ABC 139. ROBERT SUSKIND AND LESLIE LEWINTER- SUSKIND PEDIATRIC NUTRITION LIFETIME Chaired: K. Kordas ACHIEVEMENT AWARD Cochaired: A.E. Millen

Award Lecture Nutritional Epidemiology

Sun. 2:00 pm—San Diego Convention Center, 3:00 Observational Studies in Nutrition: Limitations & Need Ballroom 20D for Alternatives. K. Kordas. Univ. of Bristol. 3:25 Genes and Nutrition in the Post-GWAS Era. H. Ochs- Nutrition Education: Have We Finally Found the Way to Balcom. Univ. at Buffalo SUNY. Prepare Tomorrow’s Physicians? R.M. Suskind 3:50 Mendelian Randomization: Principles and Applications in Nutritional Sciences. C. Engelman. Univ. of Wisconsin-Madison. 4:15 Limitations to Mendelian Randomization: Threats to Causal Inference and Ways to Overcome Them. N. Davies. Univ. of Bristol. 4:40 What Can Epigenomie-wide Assocation Studies (EWAS) Tell Us About the Link between Nutrition and Health? M. Suderman. Univ. of Bristol.

47 NUTRITION SUNDAY

142. ENERGY AND MACRONUTRIENT 145. DBC: METABOLISM AND BIOAVAILABILITY OF METABOLISM RIS BUSINESS MEETING DIETARY BIOACTIVE COMPONENTS AND HOT TOPICS SEMINAR Minisymposium RIS Forum (Sponsored by: Dietary Bioactive Components RIS) (Sponsored by: Energy and Macronutrient Sun. 3:00 pm—San Diego Convention Center, Room 29A Metabolism RIS) Chaired: R. Bruno Sun. 3:00 pm—San Diego Convention Center, Room 33BC Cochaired: S. Sang Chaired: V.J. Vieira-Potter 3:00 145.1 Biotransformation of 5-Demethyltangeretin in Mice: Generation of Anti-cancer Metabolites. X. Wu, 143. EXPERIMENTAL ANIMAL NUTRITION Y. Sun, M. Wang, Z. Gao, M. Song, H. Xiao. Univ. of RIS BUSINESS MEETING AND HOT Massachusetts Amherst. TOPIC PRESENTATION 3:15 145.2 Quantification of Javamide-I and -II in Twelve Coffee Drinks and Their Effects on Sirtuin1/2/3 Enzymes and RIS Forum p53-Acetylation in THP-1 Cells. J. Park. USDA, Beltsville, MD. 3:30 145.3 The Metabolic Fate of Isotopically-Labeled (Sponsored by: Experimental Animal Nutrition RIS) Trimethylamine-N-Oxide in Humans. S. Taesuwan, C.E. Cho, Sun. 3:00 pm—San Diego Convention Center, Room 33A O.V. Malysheva, E. Bender, J. Yan, A. Thalacker-Mercer, M.A. Caudill. Cornell Univ. Chaired: K.M. Ajuwon 3:45 145.4 Nutrimetabolomics Fingerprinting to Identify Biomarkers of Whole Grain Wheat Intake. S. Sang, Y. Zhu, W. 144. TRANSDISCIPLINARY TRAINING IN Sha, P. Wang. North Carolina A&T State Univ., Kannapolis and Univ. of North Carolina at Charlotte. CHILDHOOD OBESITY PREVENTION: 4:00 145.5 Phenolic Recovery and Bioaccessibility from APPROACHES, SUCCESSES Milled and Finished Whole Grain Oat Products. M. Li, K. AND CHALLENGES Koecher, L. Hansen-TechCenter, M.G. Ferruzzi. Purdue Univ. and General Mills Inc., MN. Symposium 4:15 145.6 Major Furocoumarins in Grapefruit Are Sun. 3:00 pm—San Diego Convention Center, Room 32AB Detectable in Plasma following Consumption of Grapefruit and Grapefruit Juice. M. Moser, T.M. Vance, T. Mali, S.G. Lee, C. Chaired: S.M. Donovan Perkins, A. Provatas, A. Qureshi, O.K. Chun, E. Cho. Univ. of Connecticut, North Carolina A&T State Univ. and Warren Alpert Cochaired: G.L. Jensen Med. Sch. of Brown Univ. Nutrition Across the Lifespan: From Pediatrics 4:30 145.7 Gastrointestinal Biotransformation of to Geriatrics Resveratrol in Mice. F. Li, Y. Sun, M. Song, X. Wu, H. Xiao. Univ. of Massachusett Amherst and Sch. of Pharm., Ocean Education Univ. of China. 3:00 Illinois Transdisciplinary Obesity Prevention 4:45 145.8 Plasma Plant Sterol and Plant Sterol Intake Program (I-TOPP). S. Donovan. Univ. of Illinois in Plant-Based Diets. K. Jaceldo-Siegl, D. Lütjohann, R. at Urbana-Champaign. Sirirat, E. Haddad. Loma Linda Univ. and Univ. Clins. of 3:20 Childhood Obesity Prevention Training (COPT). Bonn, Germany. B. Rolls. Penn State 3:40 Innovation and Collaboration: Creating a 146. OBESITY: OBESITY, GUT MICROBIOME Transdisciplinary Childhood Obesity Prevention AND MACRONUTRIENTS (TOP) Graduate Education Certificate Program. J. Meendering. South Dakota State Univ. Minisymposium 4:00 Sanos Y Fuertes: Creating Culturally Relevant Programs for the University and Community. B. Rios-Ellis. (Sponsored by: Obesity RIS) California State Univ., Monterey Bay. Sun. 3:00 pm—San Diego Convention Center, Room 29B 4:20 Trainee Perspective – I-TOPP (University of Illinois). K. Robinson. Univ. of Illinois at Urbana-Champaign. Chaired: F. Greenway 4:40 Trainee Perspective – COPT (Penn State). S. Kling. 3:00 146.1 Soy Positively Impacts Cecal Microbiota Penn State of Ovariectomized Rats Selectively Bred for Low Aerobic 5:00 Panel Discussion. Capacity. T-W. Liu, T.M. Zidon, R.J. Welly, Y-M. Park, S.L. Britton, L.G. Koch, J. Padilla, V.J. Vieira-Potter, K.S. Swanson. Univ. of Illinois, Urbana, Univ. of Missour-Columbiai and Univ. of Michigan.

48 SUNDAY NUTRITION

3:15 146.2 Associations between Physical Activity and 3:45 147.4 Apiaceous and Cruciferous Vegetables Fed in the Intestinal Microbiome of College Freshmen. C.M. Whisner, the Post-initiation Stage Reduce Colonic Precancerous Lesions M. Bruening. Sch. of Nutr. and Hlth. Promotion, Arizona and the Cancer Stem Cell Marker DCLK1, and Alter the miRNA State Univ. Expression Profile in 1,2-Dimethylhydrazine-Treated Rats. 3:30 146.3 Gut Microbiota Metabolites in Infancy: S. Kim, S.P. Trudo, D.D. Gallaher. Univ. of Minnesota, St. Paul Associations with Breastfeeding and Childhood Overweight. and Univ. of Arkansas Sch. of Human Envrn. Sci. S. Bridgman, P. Koleva, R. Mandal, M. Azad, C. Field, A. 4:00 147.5 Through Metabolic Reprogramming Walnut Haqq, A. Becker, S. Turvey, P. Mandhane, P. Subbarao, May Mitigate the Stemness of Colon Cancer Stem Cells. M. Sears, D. Wishart, A. Kozyrskyj. Univ. of Alberta, Univ. S.W. Choi, J. Choi, J. Kim, S. Friso, Y. Kim. CHA Univ.,South of Manitoba, Univ. of British Columbia, Univ. of Toronto and Korea, Univ. of Verona Sch. of Med. and Ewha Womans Univ., McMaster Univ., Canada. South Korea. 3:45 146.4 Relationship between Human Gut Microbiota 4:15 147.6 The Role of Intra-abdominal Adipose Tissue in and Interleukin 6 Levels in Overweight and Obese Adults. Cancer. J. Bernard, B. Bullard. Michigan State Univ. S D. Cooper, E.B. Kim, M. Marco, B. Rust, L. Welch, W. Horn, 4:30 147.7 Microenvironment Folate Stress Promotes U R. Martin, N. Keim. Univ. of California, Davis, USDA, Davis Warburg-Metabolic Switched-Cancer Stem Cell Signaling N and Seoul Natl. Univ. Network and Stemness Features to Mediate Invasion and 4:00 146.5 Depressive Like Behavior and Changes in the Metastasis of Lung Cancers. W-J. Chen, R-F.S. Huang. Fu- Gut Microflora Are associated with a High Fat Diet in Male Jen Catholic Univ., Taiwan. Sprague Dawley Rats. G. Chompre, M.L. Cruz, S. Cruz, Y. 4:45 147.8 Cranberry Extract Initiates Intrinsic Apoptosis Yamamura, C. Appleyard. Pontifical Catholic Univ. of Puerto in HL-60 Cells by Increasing Bad Activity through the Inhibition Rico and Ponce Hlth. Sci. Univ. Med. Sch. & Ponce Res. Inst. of Akt Phosphorylation. R. Mansouri, S.S. Percival. Univ. 4:15 146.6 Obesity-Prone High-Fat Fed Rats Reduce of Florida. Caloric Intake and Adiposity and Gain More Fat-Free Mass When Allowed to Separate Protein from Carbohydrate/Fat Intake. D. 148. VITMIN: ZINC AND SELENIUM Tomé, D. Azzout-Marniche, T. Chalvon-Demersay, G. Pimentel, C. Chaumontet, N. Nadkarni, J. Piedcoq, G. Fromentin, C. Minisymposium Gaudichon, P.C. Even. AgroParisTech, INRA, Univ.Paris Saclay. 4:30 146.7 Impact of Free-Living Nutrition Intervention (Sponsored by: Vitamins and Minerals RIS)

on Microbiome in College Students at Risk for Disease: Sun. 3:00 pm—San Diego Convention Center, Room 29D FRUVEDomic Pilot Study. O.A. Famodu, C.F. Cuff, A. Cockburn, M.T. Downes, P.J. Murray, J.W. McFadden, S.E. Chaired: A. Grider Colby, J.S. Morrell, I.M. Olfert, M.D. Olfert. West Virginia Univ., Cochaired: D. Ekoue Univ. of Tennessee, Knoxville and Univ. of New Hampshire. 4:45 146.8 Effects of an Almond-Enriched Energy Restricted 3:00 148.1 Zinc-Induced Upregulation of Metallothionein- Diet on Body Composition, Visceral Adipose Tissue and Blood 2A Is Predicted by Gene Expression of Zinc Transporters Pressure in Obese Adults. J. Dhillon, R. Mattes. Purdue Univ. in Healthy Adults. A. Chu, M. Foster, S. Ward, K. Zaman, D. Hancock, P. Petocz, S. Samman. Univ. of Otago, New 147. DIET AND CANCER: ANIMAL AND Zealand, Univ. of Sydney and Macqurie Univ., Australia. MOLECULAR STUDIES 3:15 148.2 Zinc and ZIP14 (Slc39a14) Are Required for Adaptation to ER Stress in Mouse Liver. M-H. Kim, T.B. Minisymposium Aydemir, R.J. Cousins. Univ. of Florida. 3:30 148.3 Chronic Zinc Deficiency Alters Chick (Gallus (Sponsored by: Diet and Cancer RIS) gallus) Gut Microbiota Structure and Function. E. Tako, O. Koren. Sun. 3:00 pm—San Diego Convention Center, Room 29C USDA, Cornell Univ. and Fac. of Med., Bar-Ilan Univ., Israel. 3:45 148.4 Serum Zinc and Hemoglobin Concentrations Chaired: J-R. Zhou in Persons with Human Immunodeficiency Virus Infection: The Positive Living with HIV Study. K. Poudel-Tandukar. Univ. of Cochaired: S. Wang Massachusetts Amherst. 3:00 147.1 Dietary Tomato Reduces Castration-Resistant 4:00 148.5 Novel Role of Glutathione Peroxidase-1 in Prostate Cancer Burden in the TRAMP Model. J.W. Smith, J.L. Liver and Muscle Protein Metabolism of Mice. L. Tao, Z.P. Rowles III, R.J. Miller, S.K. Clinton, W.D. O’Brien; Jr., J.W. Zhao, X.G. Lei. Cornell Univ. Erdman; Jr. Univ. of Illinois at Urbana-Champaign and The 4:15 148.6 Removal of Glutathione Peroxidase 4 in Mouse Ohio State Univ. Liver Leads to Early Lethality and Vitamin E Can Compensate 3:15 147.2 The Effect of Oil Palm Phenolics on Pancreatic for Its Loss. B.A. Carlson, R. Tobe, E. Yefremova, P.A. Tsuji, Ductal Adenocarcinoma in Transgenic Mouse Model. V.J. Hoffmann, U. Schweizer, V.N. Gladyshev, D.L. Hatfield, N.H. Razalli, P. Gowthaman, N. Saadat, S. Vemuri, A. Goja, M. Conrad. NCI, NIH, Ritsumeikan Univ., Japan, Helmholtz R. Sambanthamurthi, S.V. Gupta. Wayne State Univ. and Ctr. Munich, Towson Univ., OD, NIH, Rheinische Friedrich- Malaysian Palm Oil Bd., Kajang. Wilhelms-Univ. Bonn and Harvard Med. Sch. 3:30 147.3 Dried Plums Modify Fecal Short Chain Fatty 4:30 148.7 Selenium (Se) Homeostasis in Chicken Central Acid Concentrations and Gene Expression in a Rat Model of Nervous System Involves Selenoprotein Expression from Colon Carcinogenesis. D.V. Seidel, K.K. Hicks, S.S. Taddeo, Insufficient to Excess Se. J. Li, X. Jiang, C. Cao, C. Zhang, X. M.A. Azcarate-Peril, R.J. Carroll, N.D. Turner. Texas A&M Li, W. Li. Col. of Vet. Med., Northeast Agr. Univ., China. Univ. and Univ. of North Carolina at Chapel Hill.

49 NUTRITION SUNDAY

4:45 148.8 Soy Protein Diet Preserves Skilled Ladder 150. GLOBAL NUTRITION: IMPACT OF NUTRITIONAL Rung Walking Performance after Stroke Better Than SUPPLEMENTATION AND PREDICTORS Isoflavones Alone in Adult and Aged Male Rats. R.A. Sunde, OF ADHERENCE R.M. Taylor, J-L. Li. Univ. of Wisconsin-Madison and Northeast Agr. Univ., China. Minisymposium

149. COMMUNITY AND PUBLIC HEALTH NUTRITION: (Sponsored by: Global Nutrition Council) FOOD SECURITY AND ITS CONNECTIONS TO Sun. 3:00 pm—San Diego Convention Center, Room 30B NUTRITION AND HEALTH SECTION I Chaired: L.M. Neufeld

Minisymposium Cochaired: S. Young

(Sponsored by: Community and Public Health 3:00 150.1 Maternal Lipid-Based Nutrient Supplements Nutrition RIS) Did Not Reduce Depressive Symptoms during Pregnancy

Sun. 3:00 pm—San Diego Convention Center, Room 30A and Lactation in Rural Bangladesh. S.L. Matias, M.K. Mridha, S.A. Khan, S. Hussain, Z. Siddiqui, S. Vosti, C.D. Arnold, Chaired: H.A. Eicher-Miller K.G. Dewey. Univ. of California, Davis, ICDDR and Save the Children, Dhaka, Bangladesh. Cochaired: L. Cordeiro 3:15 150.2 Individual and Structural Environmental 3:00 149.1 Differential Associations of Food Insecurity Influences on Utilization of Iron and Folic Acid Supplementation Risk on Dietary Intake-Frequency among Parents and Their among Pregnant Women in Harare, Zimbabwe. C.B. Tinago, Adolescent Children. E. Calloway, T. Smith, C. Pinard, A. Oh, L. Annang Ingram, C.E. Blake, E.A. Frongillo. Univ. of L. Nebeling, E. Hennessy, A. Yaroch. Gretchen Swanson Ctr. South Carolina. for Nutr., Omaha and NCI, NIH. 3:30 150.3 Social Support Enhances Adherence 3:15 149.2 Women’s Empowerment and Food Security to Antenatal Calcium and Iron-Folic Acid Supplements: Status: A Global Comparative Study of Women Living in Acceptability and Impact of Adherence Partners. S. Martin, M. Rural and Urban Areas. K. Sinclair, D. Ahmadigheidari, Omotayo, R. Stoltzfus, K. Dickin. Cornell Univ. D. Dallmann, H. Melgar-Quiñonez. McGill Univ., Ste. Anne de 3:45 150.4 High Prevalence of Low Urinary Iodine among Bellevue, QC. Pregnant and Lactating Women of Bangladesh Does Not 3:30 149.3 Altered Daily Activities and Shame Resulting Respond to Daily Lipid-Based Nutrient Supplement Containing from Children Experiencing Food Insecurity in Rural South 250 µg Iodine. M.K. Mridha, S.L. Matias, S.A. Khan, R.R. Carolina and Oregon. E.A. Frongillo, J. Bernal, E. Adams, Paul, Z. Siddiqui, B. Ullah, S. Hussain, R.T. Young, C.D. E. Massey, T. Rosemond, C.E. Blake. Univ. of South Carolina, Arnold, K.G. Dewey. Univ. of California, Davis, ICDDR,B, Care Univ. Simón Bolívar, Caracas and Oregon Hlth. & Sci. Univ. Bangladesh and Save the Children, Dhaka, Bangladesh. 3:45 149.4 Marginal Food Insecurity Is Associated 4:00 150.5. Physical Activity and Work Productivity in with Increased Sodium and Decreased Fruit Consumption Response to Iron and Iodine Double-Fortified Salt Trial in in Mothers and Toddlers from Low-Income Households. Indian Tea Estate Workers. M.M. Blakstad, J.E.H. Nevins, M. Spiker, K. Hurley, Y. Wang, R. Arbaiza, M. Black. Johns S. Venkatramanan, E.M. Przybyszewski, J.D. Haas. Cornell Hopkins Bloomberg Sch. of Publ. Hlth. and Univ. of Maryland Univ. and McGill Univ., Ste. Anne de Bellevue. Sch. of Med. 4:15 150.6 Are We Done? Predicting the Impact of 4:00 149.5 The Role of Television during Family Meals: Supplement Use and Mandatory and Voluntary Folic Acid Enable or Disrupter of Communication. C.E. Blake, T.N. Fortification on the Risk of Neural Tube Defects in the United Rosemond, J. Bernal, E.A. Frongillo. Univ. of South Carolina States. K.S. Crider, O. Devine, Y.P. Qi, S.C. Tinker, R.J. Berry. and Univ. Simón Bolívar. Ctrs. for Dis. Control and Prevent. and Cater Consulting, Atlanta. 4:15 149.6 Strong Interpersonal Relationships Buffer 4:30 150.7 Effect of Short-Term Maternal Supplementation the Impact of Chaos on Quality of Family Meal Interactions with Small Amounts of Vitamin A or Beta-Carotene on Breast in Food-Insecure Households. T.N. Rosemond, C. Blake, J. Milk Retinol Concentrations among Lactating Filipino Women. Bernal, M.P. Burke, E.A. Frongillo. Univ. of South Carolina, R. Engle-Stone, A. Osei, M.F.D. Reario, A. Hall, J.E. Univ. Simon Bolivar, Venezuela and USDA, Alexandria, VA. Arsenault, N. Haselow, G. Lietz, K.H. Brown, M.J. Haskell. 4:30 149.7 Food Insecurity’s Association with Gestational Univ. of California, Davis, Helen Keller Intl., NY, Newcastle Weight Gain Varies by Pre-pregnancy Weight and Parity. Univ., U.K. and Bill & Melinda Gates Fndn., Seattle. E. Metallinos-Katsaras, E. Siu, R. Colchamiro. Simmons 4:45 150.8 A Comprehensive Nutrition Program Improved Col. and Massachusetts Department of Publ. Hlth., Boston. Nutritional Status among Children Aged 6 to <24 Months in 4:45 149.8 High Household Food Insecurity Impacts Rural Malawi. Y. Kang, K. Hurley, A.B. Monclus, J. Ruel- Dietary Patterns in Rural and Urban American Indian Families Bergeron, R. Oemcke, L.S.F. Wu, M. Mitra, J. Phuka, P. with Young Children. E. Tomayko, K. Mosso, K. Cronin, R. Christian. Johns Hopkins Bloomberg Sch. of Publ. Hlth. and Prince, A. Adams. Univ. of Wisconsin-Madison. Col. of Med., Univ. of Malawi.

50 SUNDAY NUTRITION

151. MATERNAL, PERINATAL AND PEDIATRIC: 152. NUTRITION EDUCATION: DEVELOPING MEETING THE NUTRITIONAL NEEDS OF HEALTHY EATING AND PHYSICAL ACTIVITY PEDIATRIC POPULATIONS BEHAVIORS ACROSS THE LIFESPAN

Minisymposium Minisymposium Maternal, Perinatal and Pediatric RIS (Sponsored by: Nutrition Education and Behavioral Science RIS) Sun. 3:00 pm—San Diego Convention Center, Room 30C Sun. 3:00 pm—San Diego Convention Center, Room 30D Chaired: B. Olson Chaired: R. Scherr Cochaired: J.T. Smilowitz Cochaired: J.L. Kaar S 3:00 151.1 Choline Intake during Pregnancy and Genetic Polymorphisms Influence Choline Metabolism in Chinese 3:00 152.1 Nutrition Messages in Picture Book Fiction for 4 U Preterms Receiving Total Parenteral Nutrition Therapy. J. Zhu. to 8 Year Old Children. O.A. Matvienko. Univ. of Northern Iowa. N Sch. of Med., Shanghai Jiao Tong Univ. 3:15 152.2 Perceived Barriers to Physical Activity during 3:15 151.2 Early Weight Gain, Linear Growth, and Mid- Pregnancy among Participants of the Special Supplemental childhood Blood Pressure. W. Perng, S.L. Rifas-Shiman, M.S. Nutrition Program for Women, Infants and Children in Southern Kramer, L.K. Haugaard, E. Oken, M.W. Gillman, M.B. Belfort. California. M. Koleilat, N. Vargas, G. Kodjebacheva. California Univ. of Michigan Sch. of Publ. Hlth., Harvard Med. Sch./ State Univ., Fullerton and Univ. of Michigan-Flint. Harvard Pilgrim Hlth. Care Inst., McGill Univ. Fac. of Med., 3:30 152.3 Behavioral and Sociodemographic Correlates Univ. of Copenhagen, Bispebjerg and Frederiksberg Hosps., of Overall Diet Quality Over 4 Years in a National Cohort of Copenhagen, Harvard Sch. of Publ. Hlth. and Brigham and U.S. Emerging Adults. L.M. Lipsky, T.R. Nansel, D. Haynie, D. Women’s Hosp. Liu, K. Li, C. Pratt, R.J. Iannotti, B. Simons-Morton. NICHD, 3:30 151.3 Lean Mass Accretion Associates with Vitamin NIH, Col.. of Hlth. and Human Sci., Colorado State Univ., D Intake: A 6 Month Randomized Controlled Trial in 2-8 Year NHLBI, NIH and CDM Gp., Bethesda. Olds Using Fortified Foods. N.R. Brett, C.A. Parks, P. Lavery, 3:45 152.4 Does Healthcare Provider Advice Matter for S. Agellon, C.A. Vanstone, J.L. Maguire, F. Rauch, H.A. Gestational Weight Gain? N.P. Deputy, A.J. Sharma, S.Y. Weiler. Sch. of Dietetics and Human Nutr., McGill Univ., Li Ka Kim. Emory Univ. and Ctrs. for Dis. Control and Prevent. Shing Inst. of St. Michael’s Hosp., Univ. of Toronto and Shriners 4:00 152.5 No Time for Family Meals – What’s a Family to Hosp. for Children, McGill Univ. Do? A.W. Watts, J. Berge, K. Loth, N. Larson, D. Neumark- 3:45 151.4 Erythrocyte Omega-3 Long Chain Sztainer. Univ. of Minnesota, Minneapolis. Polyunsaturated Fatty Acids Are Associated with Lumbar Spine 4:15 152.6 If You’re Happy and You Know It: Associations but Not Whole Body Bone Mineral Density in Healthy Children. between Emotion, Social Context, and Food Choices in College C.A. Parks, N.R. Brett, S. Agellon, P. Lavery, C.A. Vanstone, Freshmen. J. Ashurst, I. van Woerden, M. Bruening. Arizona J.L. Maguire, F. Rauch, H.A. Weiler. Sch. of Dietetics and State Univ. Human Nutr., McGill Univ., Li Ka Shing Knowledge Inst. of St. 4:30 152.7 Physical Activity Level, Modeling, and Michael’s Hosp., Univ. of Toronto and McGill Univ., Montreal. Importance to Mothers of Preschool Children. J.T. Martin- 4:00 151.5 Standing by Human Milk through Thick and Biggers, V. Quick, J. Worobey, C. Byrd-Bredbenner. Thin: The Effect of Thickeners on Human Milk Viscosity. Rutgers Univ. J.K. Koo, L. Bode, J.H. Kim. UCSD/Rady Children’s Hosp. of 4:45 152.8 Perceptions on Weight Management for San Diego. Survivors of Pediatric ALL from Parents and Pediatric Oncology 4:15 151.6 Maternal Plasma Folate, Vitamin B12 Levels Professionals: A Mixed Methods Study. W. Chang, S. Folta, R. and Multivitamin Supplementation during Pregnancy and Hill, M. Kelly, S. Meagher, E. Danahy, P. Bowman, F.F. Zhang. Risk of Autism Spectrum Disorder in the Boston Birth Cohort. Tufts Univ., Boston, Smith Col., Cook Children’s Med. Ctr., Fort R. Raghavan, M.D. Fallin, X. Wang. Johns Hopkins Bloomberg Worth and Tufts Med. Ctr. Sch. of Publ. Hlth. 4:30 151.7 Novel Tool for Discrimination of Feeding Intolerance and Necrotizing Enterocolitis Risk in the Preterm Infant. J. Naberhuis, C. Wetzel, K. Tappenden. Baylor Col. of Med., USDA, Houston, Carle Fndn. Hosp., Urbana and Univ. of Illinois at Urbana-Champaign. 4:45 151.8 Dietary Intakes of Formula-Fed Infants Consuming a Meat- or Dairy-Based Complementary Diet: A Semi-controlled Feeding Trial. M. Tang, K.E. Griese, N.F. Krebs. Univ. of Colorado Anschutz Med. Campus.

51 NUTRITION SUNDAY

153. INTERNATIONAL FORUM – KOREA: HEALTH An interest on health and functional foods is rapidly emerging AND FUNCTIONAL FOODS: WHERE WE ARE along with expanding elderly populations. This session will review AND WHERE WE GO progress in the field of health and functional foods and share current knowledge on the mechanisms of actions on specifically International Forum chosen bioactive components in the aspects of gut, liver and adipose tissue health with Korean researchers working in both (Organized and Sponsored by: The Korean Nutrition Society) Korea and USA. Sun. 3:00 pm—San Diego Convention Center, Room 28DE 3:00 Effect of Sasa Quelpaertensis Leaf Extracts on Intestinal Inflammation and Colon Cancer Stemness. Y. Kim. Chaired: Y-S. Cha Ewha Womans Univ. Cochaired: Y. Park 3:25 Role of Piceatannol in Adipose Lipolysis and Obesity. K-H. Kim. Purdue Univ. 3:50 A Novel Role of Astaxanthin in the Modulation of Histone Deacetylase 9 for the Prevention of Liver Fibrosis. J-Y. Lee. Univ. of Connecticut. 4:15 Discussion.

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52 SUNDAY PATHOLOGY Pathology

154. COMMITTEE FOR CAREER DEVELOPMENT 156. HCS SYMPOSIUM: THE 3D BRAIN: FROM AND DIVERSITY WORKSHOP AND BREAKFAST: DIFFUSION MRI TO ULTRASTRUCTURE CAREER-CHOICE OPPORTUNITIES IN SCIENCE Symposium Workshop (Sponsored by: the ASIP Immunohistochemistry (Sponsored by: the ASIP Committee for Career & Microscopy Scientific Interest Group and The Development & Diversity ) Histochemical Society ) Sun. 7:00 am—San Diego Marriott Marquis & Marina Sun. 8:30 am—San Diego Convention Center, Room 4 S Hotel, Temecula Chaired: D. Rosene U Chaired: C. Kolarcik Cochaired: M. Barroso N Cochaired: J. Arboleda-Velasquez Neurobiology Career Development Imaging, Immunohistochemistry and Microscopy 7:00 Introduction. C. Kolarcik. Univ. of Pittsburgh. Neuropathology 7:10 Molecular Diagnostics/Clinical Chemistry. G. Tsongalis. Dartmouth-Hitchcock Med. Ctr. 8:30 Diffusion MRI of the Brain Connectome: Problems and 7:30 Scientific Publishing. A. Cox. The American Journal Possibilities. V. Wedeen. Harvard Univ. of Pathology. 9:30 High-resolution Structural and Molecular Imaging of the 7:50 Science Administration (Non-profits, Government, Brain. K. Chung. MIT. For-profits). M. Sobel. American Society for Investigative Pathology. 157. JOURNAL OF HISTOCHEMISTRY & 8:10 Science Public Policy. Y. Seger. Federation of American CYTOCHEMISTRY LECTURE Societies for Experimental Biology. 8:30 Technology/Entrepreneur/Start-Ups. C. Parkos. Univ. Lecture of Michigan. 8:50 Closing Remarks. J. Arboleda-Velasquez. Schepens Sun. 10:30 am—San Diego Convention Center, Room 4 Eye Research Inst. Chaired: S. Hewitt

155. AMERICAN SOCIETY FOR MATRIX Imaging, Immunohistochemistry and Microscopy BIOLOGY LECTURE 10:30 Multiscale Optical Imaging of the Living Brain. E. Hillman. Columbia Univ. Lecture (Sponsored by: ASIP and the American Society for 158. SCVP SYMPOSIUM: CYTOKINE SIGNALING IN Matrix Biology) THE HEART

Sun. 8:30 am—San Diego Convention Center, Room 5A Symposium Cancer Biology (Sponsored by: ASIP and the Society for Cardiovascular Matrix Pathobiology Pathology )

Neoplasia Sun. 8:30 am—San Diego Convention Center, Room 2

8:30 The Matricellular Protein Thrombospondin 1 in the Chaired: J.R. Stone Myeloma Microenvironment. J. Murphy-Ullrich. Univ. of Alabama at Birmingham. Cochaired: J. Homeister Inflammation/Immunity Cardiac Pathobiology Cell and Tissue Injury 8:30 The Role of Cardiac Innate Immunity in Cardiac Injury. M. Willis. Univ. of North Carolina at Chapel Hill. 9:15 The Role of TGF-beta Signaling in Cardiac Remodeling. N. Frangogiannis. Albert Einstein Med. Ctr. 10:00 NLRP3 in Inflammasome Inhibition in Acute Myocardial Injury. S.Toldo. Virginia Commonwealth Univ. Med. Ctr.

53 PATHOLOGY SUNDAY

10:45 Inflammatory Cytokines Induce a Novel Cardioprotective 10:30 160.5 Surface Topography during Neural Stem Cell Zing Finger Protein, MCPIP. P. Kolattukudy. Univ. of Differentiation Regulates Cell Migration and Cell Morphology. Central Florida. C. Czeisler, A. Short, B. Stocker, J. Cronin, J. Lannutti, J. Winter, J.J. Otero. The Ohio State Univ. 159. LIVER PATHOBIOLOGY WORKSHOP: LIVER INJURY, INFLAMMATION, AND 161. XVITH ANNUAL ASIP/AAA CAREER TUMORIGENESIS: IMPLICATIONS IN CANCER DEVELOPMENT AND MENTORING PROGRAM PREVENTION AND TREATMENT AND LUNCH: HOW TO NETWORK EFFICIENTLY AND CHOOSE A CAREER PATH Workshop Special Session (Supported by an unrestricted educational grant from Elsevier) (Sponsored by: the ASIP Committee for Career Development & Diversity and the American Association Sun. 8:30 am—San Diego Convention Center, Room 3 of Anatomists) Chaired: S.P.S. Monga Sun. 11:45 am—San Diego Marriott Marquis & Marina Cochaired: X. Chen Hotel, Presidio 1

Cancer Biology Chaired: D. Bielenberg Liver Pathobiology Cochaired: J. Jones-Triche Neoplasia Career Development 8:30 Hepatic Ploidy. A. Duncan. Univ. of Pittsburgh. 11:45 Introduction. D. Bielenberg. Harvard Med. Sch., 9:00 Hepatic Fibrosis and Cancer. B. Schnabl. UCSD. Children’s Hosp. 9:30 FXR/HNF4a and Cancer. U. Apte. Univ. of Kansas 11:50 Tips and Tools for Effective Networking. L. McManus. Med. Ctr. Univ. of Texas Hlth. Sci. Ctr. 10:00 Progenitors and Cancer. E. Seki. UCSD. 12:10 Speed Networking Format. J. Jones-Triche. Univ. 10:30 Modeling Human HCC in MIce. S.P. Monga. Univ. of Michigan. of Pittsburgh. 11:00 Cholangiocarcinoma. T. Wu. Tulane Univ. Hlth. Sci.s Ctr. Speed Networking 12:15 Table 1: Technology/Entrepreneur/Start-Ups. C. Parkos. 160. EXTRACELLULAR MATRIX Univ. of Michigan Med. Sch. 12:15 Table 2: Scientific Editor. A. Cox. ASIP. Minisymposium 12:15 Table 3: Science Administration. M. Sobel. ASIP. 12:15 Table 4: Public Policy. Y. Seger. FASEB Publ. Affairs. Sun. 9:30 am—San Diego Convention Center, Room 5A 12:15 Table 5: Molecular Diagnostics/Clinical Chemistry. Chaired: W. Stetler-Stevenson - Junior Faculty G. Tsongalis. Dartmouth Med. Sch. 12:15 Table 6: Scientific Consulting. C. Yates. Univ. Cochaired: R. Iozzo of Pittsburgh. Matrix Pathobiology 12:15 Table 7: . C. Austin, S. Pirie-Shephard. Genentech, Pfizer. Neoplasia 12:15 Table 8: Government Positions. E. Unger. CDC. 9:30 160.1 Twist1 Phosphorylation Contributes to 12:15 Table 9: Teaching/Academic Administration. V. Holloway. Pulmonary Fibrosis through Angiopoietin-Tie2 Signaling. DeVry, Inc. A. Mammoto, A. Jiang, E. Jiang, T. Mammoto. Boston Children’s Hosp. 162. HOST PATHOGEN INTERACTIONS 9:45 160.2 Extracellular Vesicles Isolated from Human Mesenchymal Stem Cells Promote Resolution of Pulmonary Symposium Fibrosis. T.P. Shentu, S. Wong, C. Espinoza, M. Cernelc- Sun. 2:00 pm—San Diego Convention Center, Room 2 Kohan, J. Hagood. UCSD and Rady Hosp. of San Diego. 10:00 160.3 Matrix Metalloproteinase-28 Activates Chaired: D.A. Milner, Jr. Signal Transducer and Activator of Transcription 1 to Induce Macrophage M1 Polarization. M.L. Lindsey, P.L. Cannon, E.R. Cochaired: A. Nusrat Flynn, M. Jung, R.P. Iyer, K.Y. DeLeon-Pennell, Y. Ma. Univ. Epithelial and Mucosal Pathobiology of Mississippi Med. Ctr. 10:15 160.4 Stromal Cell-Derived Extracellular Matrix Microbiome Stimulates Mesenchymal Stem Cell Proliferation and SSEA4 Immunopathology Expression When Used as Supplement in Cell Growth Medium. R. Zamilpa, I. Flores, M.M. Navarro, S. Griffey. StemBioSys 2:00 Bacteria. A. Neish. Emory Univ. Inc. and Univ. of Texas Hlth. Sci. Ctr. at San Antonio. 2:45 Bacteria. P. Dorrestein. UCSD. 3:30 Virus. K. Cadwell. NYU Sch. of Med.

54 SUNDAY PATHOLOGY

4:15 162.1 Giardia duodenalis Directly Depletes Mucins Charleston. (57.10) in Intestinal Goblet Cells. C.B. Amat, J-P. Motta, K. Chadee, 4:00 Th1 Effector T Cells Induce Cardiac Fibroblasts A.G. Buret. Univ. of Calgary, Canada. Transition to Myofibroblasts and Contribute to Pressure Overload-Induced Cardiac Fibrosis. T. Nevers, A.M. 163. MOLECULAR AND CELLULAR FOUNDATIONS Salvador, F. Velazquez, M. Aronovitz, R. Blanton, P. OF GLIAL ONCOGENESIS: HINTS FOR Alcaide. Tufts Med. Ctr. and Tufts Univ. (306.7) PREVENTION AND THERAPY 4:10 Dimethyl Fumarate Ameliorates Pulmonary Hypertension In Vivo and Prevents Fibrosis via TRCP-Mediated Degradation of -Catenin and TAZ. Symposium β β A. Grzegorzewska, R. Han, F. Seta, L. Stawski, C. Sun. 2:00 pm—San Diego Convention Center, Room 3 Feghali-Bostwick, J. Browning, M. Trojanowska. Boston Univ. and Med. Univ. of South Carolina. (50.2) Chaired: W. Tourtellotte 4:20 Mechanisms Underlying the Induction of a Profibrotic S Cochaired: E. Whitley Epithelial Phenotype during Renal Fibrosis. J. Folke U Bialik, M. Rozycki, P. Speight, Z.M. Miranda, S.G. N Neurobiology Szeto, D.A. Yuen, Q. Dan, K. Szászi, S.F. Pedersen, Neuropathology A. Kapus. St. Michael’s Hosp., Toronto, Univ. of Copenhagen and Univ. of Toronto. (445.6) Neoplasia 4:30 Absence of Mast Cells in an Experimental Model of Pulmonary and Cardiac Fibrosis, the CUX-1 Mice. 2:00 Hide and Seek: A Surprising Role for Extrachromosomal N.A. Reddy, F. Raza, A. Said, S. Livingston, D. EGFR Mutations in Glioblastoma Pathogenesis. Jacobsen, D. Kearns, R. Baybutt, G. Van Den P. Mischel. UCSD. Heuvel, A. Molteni, S. Hamidpour. Univ. of Missouri 2:45 Neuronal Activity Promotes Glioma Growth. Kansas City, Wheaton Col., IL and Western Michigan H. Venkatesh. Stanford Sch. of Med. Univ. (50.10) 3:30 Targeting Developmental Pathways in Glioblastoma. 4:40 TMPRSS4: A Novel Serine Protease Involved in IPF S. Kesari. UCSD. Development? A.M. Valero, J. Cisneros, R. Ramírez, 4:15 Therapeutic Hypothesis Testing With Patient Derived M. Gaxiola, C. Becerril, A. Pardo, M. Selman. Fac. Brain Tumor Xenograft Models. C. James. of Sci, Natl. Autonomous Univ. of Mexico and INER, Northwestern Univ. Feinberg Sch. of Med. Mexico City. (50.8) 164. CELL INJURY WORKSHOP: PROTEOTOXICITY 165. ENDOTHELIAL CELL BIOLOGY AND CELL INJURY Minisymposium Workshop Sun. 2:00 pm—San Diego Convention Center, Room 5A (Sponsored by: the ASIP Cell Injury Scientific Interest Group) Chaired: R. Mitchell

Sun. 2:00 pm—San Diego Convention Center, Room 4 Cochaired: A. Adam

Chaired: M. Willis Vascular Biology

Cochaired: C.C. Yates 2:00 165.1 Knockdown of Mechanosensitive miRNA Cluster—miR-106b~25 Decreases Endothelial Proliferation Cell and Tissue Injury and Prevents Atherosclerosis in ApoE-/- Mice. S. Kumar, H. Jo. Neuropathology Emory Univ. 2:15 165.2 Dietary Nitrate Supresses Leukocyte 2:00 Proteotoxicity and Cell Injury. M. Willis. Univ. of North Recruitment and Activation in Apolipoprotein E Knockout Mice. Carolina at Chapel Hill. R.S. Khambata, S.M. Ghosh, K.S. Rathod, T. Thevathasan, 2:10 The Interplay Between Autophagy and the Ubiquitin- A. Ahluwalia. Barts and The London Sch. of Med. and Dent., Proteasome System in Cardiac Proteotoxicity. Queen Mary Univ. of London. X. Wang. Univ. of South Dakota. 2:30 165.3 The Critical Role of SENP1-Mediated GATA2 2:40 Role of Amylin in Neuron Proteotoxicity. F. Despa. Univ. DeSUMOylation in Graft Arteriosclerosis by Promoting of Kentucky. Endothelial Activation. C. Qiu, Y. Wang, X. Zhu, L. Song, H. 3:10 Proteotoxicity and the Role of the Unfolded Protein Zhang, L. Qin, G. Tellides, W. Min, L. Yu. Zhejiang Univ. Col. Response. L. Wiseman. The Scripps Res. Inst. of Life Sci., China and Yale Univ. Sch. of Med. 3:40 Inhibiting Cardiac Fibrosis in Myocardial Infarction by 2:45 165.4 Neuropilin 2 Deficiency Prolongs Skin CXCL10 Agonist Peptide. L. Espinoza, J. Jaynes, Inflammation and Edema. D.R. Bielenberg, P. Mucka, R. Bodnar, M.S. Willis, C.C. Yates. St. Mary’s Univ., N. Levonyak, E. Geretti, B.M.M. Zwaans, X. Li, I. Adini, TX, Tuskegee Univ., Univ. of Pittsburgh Sch. of Med., M. Klagsbrun, R.M. Adam. Harvard Med. Sch., Boston Univ. of North Carolina at Chapel Hill Sch. of Med. Children’s Hosp. and Univ. of Pittsburgh Sch. of Nursing. (1178.1) 3:00 165.5 Sepsis-Associated Proteinase 3 Induces 3:50 FPR1 and Activation of Intestinal Fibroblasts. Endothelial Permeability. E.K. Patterson, G. Cepinskas, K. T.A. Reaves, M. Anderson-Thomas, A. Nillas, M. Inoue, D.D. Fraser. Lawson Hlth. Res. Inst., London, ON and Lecher. Med. Univ. of South Carolina and Col. of Western Univ., Canada.

55 PATHOLOGY SUNDAY

3:15 165.6 STAT3 Regulates Endothelial Permeability 4:45 165.12 Leukocytes Exhibit Discrete Rhythms in Their Downstream of the Pro-inflammatory Cytokines IL6 and TNF-α. Recruitment Patterns to Arteries and Veins. A. de Juan, D. H. Alsaffar, N. Martino, P. Vincent, A. Adam, A. Lowery. Druzd, G. Zuchtriegel, K. Kraus, C. Reichel, C. Scheiermann. Albany Med. Col. Walter Brendel Ctr. of Exptl. Med. and Ludwig Maximilians 3:30 165.7 Platelets Direct Leukocytes to Their Sites of Univ., Munich. Extravasation. G. Zuchtriegel, B. Uhl, D. Puhr-Westerheide, M. Pörnbacher, K. Lauber, F. Krombach, C.A. Reichel. 166. ASIP ROUS-WHIPPLE AWARD LECTURE Ludwig Maximilian Univ. of Munich. 3:45 165.8 Microvascular Endothelial Cells Can Exhibit Award Lecture Autophagy In Vivo: Role in Neutrophil Transendothelial Cell Migration? C.M. Pickworth, R. Beal, N. Reglero, L. Lintermans, Sun. 5:00 pm—San Diego Convention Center, Room 2 B. Colom, M-B. Voisin, M. Golding, S. Nourshargh. Barts Cancer Biology and The London Sch. of Med. and Dent., Queen Mary Univ. of London. Neoplasia 4:00 165.9 OxLDL Exerts a Biphasic Effect on Endothelial 5:00 ASIP Rous-Whipple Award Lecture: The Microscope Function: A Role for Oxidised Lipids in Angiogenesis and as a Tool for Disease Discovery: A Voyage through Inflammation. M. Olding, M.R. Ardern-Jones, E. Healy, the Eyes of a Hematopathologist. E. Jaffe. T.M. Millar. Univ. of Southampton. Hematopathology Section, Laboratory of Path, 4:15 165.10 JAM-C Deficiency Primes Endothelial Cells for CCR, NCI. a Pro-inflammatory State. N. Reglero, R. Beal, C. Cabrera, C. Pickworth, M. Golding, J. Whiteford, T. Nightingale, B. Imhof, M.R. Barnes, S. Nourshargh. Barts and London Sch. 167. THE HISTOCHEMICAL SOCIETY MEMBER of Med. and Dent., Queen Mary Univ. of London and Ctr. Med. AWARDS PRESENTATION, BUSINESS MEETING Univ., Univ. of Geneva. AND RECEPTION 4:30 165.11 Cell-Type Specific Mechanisms Regulate Rhythmic Leukocyte Migration to Tissues. W. He, K. Kraus, Business Meeting D. Druzd, A. de Juan, L. Ince, C-S. Chen, C. Scheiermann. (Supported by The Histochemical Society) Ludwig Maximilians Univ., Munich. Sun. 6:00 pm—San Diego Marriott Marquis & Marina Hotel, Temecula

Visit the Exhibits April 3–April 5 Exhibit Hours Sunday–Tuesday 9:00 AM–4:00 PM

56 SUNDAY PHARMACOLOGY Pharmacology

168. JULIUS AXELROD AWARD IN PHARMACOLOGY 170. ADVANCES IN TOXICOGENETICS OF METALS LECTURE: THERAPIES OF BRAIN DISEASES, PAST, PRESENT AND FUTURE Symposium (Sponsored by: The Division for Toxicology) Award Lecture (Cosponsored by: The Divisions for Behavioral Sun. 8:30 am—San Diego Convention Center, Room 16AB Pharmacology, Cancer Pharmacology, and Neurobiology Molecular Pharmacology) The Julius Axelrod Award is presented annually for significant Sun. 9:30 am—San Diego Convention Center, Room 15B S contributions to understanding the biochemical mechanisms Cochaired: J. Kim amd T. Maher U underlying the pharmacological actions of drugs and for N contributions to mentoring other pharmacologists. The Award Toxicology was established in 1991 to honor the memory of the eminent Cancer Biology American pharmacologist who shaped the fields of neuroscience, drug metabolism, and biochemistry and who served as a mentor Neurobiology for numerous eminent pharmacologists around the world. 9:30 Influence of Brain Iron Overload on Behavioral and 8:30 Introduction. Neurochemical Toxicity. J. Kim. Northeastern Univ. 8:35 Therapies of Brain Diseases, Past, Present and Future. 10:00 Neurobehavioral Effects of Lead (Pb) and Manganese J. Rossier. Neurosci. Paris Seine. Individually and in Combination in Developmentally- Exposed Rats. T. Maher. MCPHS Univ. 169. JULIUS AXELROD SYMPOSIUM: NEW 10:30 A Novel Molecular Mechanism of Arsenic in Modulating VISTAS ON DRUG AND GENE THERAPIES OF Autophagy and Nrf2 Stress Responses. D. Zhang. COGNITIVE DEFICITS IN DOWN SYNDROME, Univ. of Arizona. 11:00 Mechanisms of Cisplatin Nephrotoxicity. N.S. Pabla. AUTISM, LEUCODYSTROPHIES AND The Ohio State Univ. ALZHEIMER’S DISEASE 11:30 Ferroportin Deficiency Impairs Manganese Metabolism in Flatiron Mice. M. Wessling-Resnick. Harvard T.H. Symposium Chan Sch. of Publ. Hlth. (Supported by the John V. Croker Fund) 171. NEWLY RECOGNIZED GPCRS IN HEALTH, Sun. 9:30 am—San Diego Convention Center, Room 16AB DISEASE AND AS THERAPEUTIC TARGETS Chaired: J. Rossier Symposium Neurobiology (Sponsored by: The Division for Translational and 9:30 Comments on the 1986 Seminal Paper: Benzodiazepine Clinical Pharmacology) Inverse Agonists Improved Performances in Learning and Memory Tasks. J. Rossier. Neurosci. Paris Seine. (Cosponsored by: The Divisions for Molecular 9:40 Treating Cognitive Deficits in a Mouse Model of Down Pharmacology, Cardiovascular Pharmacology, and Syndrome Using GABA-A Alpha 5 Inverse Agonists. Neuropharmacology ) M.C. Potier. Inst. Cerveau et de la Moelle Epinière, Paris. Sun. 9:30 am—San Diego Convention Center, Room 15A 10:05 Alpha 5 Benzodiazepine Inverse Agonists Clinical Studies for the Treatment of Cognitive Deficits in Down Syndrome Cochaired: R. Corriden and P.A. Insel Patients. M. Rafii. Univ. of California, San Diego. 10:30 The Diuretic Bumetanide Improves Social Processing in Translational and Clinical Pharmacology Individuals with Autism. N. Hadjikhani. Harvard Med. Cancer Biology Sch., Boston. 10:55 Strategy for Alzheimer’s Disease: The Neurobiology Cholesterol Connection. N. Cartier. INSERM Mircen 9:30 GPCRs and the Druggable Genome. B. Roth. Univ. of CEA, Fontenay-aux-Roses, France. North Carolina at Chapel Hill Sch. of Med. 11:20 Correcting Memory Deficits in Fragile X Syndrome by 10:00 Chemosensory GPCRs as Targets for Endogenous Targeting Rac1/PAK1 Signaling. L. Martinez, M.V. Ligands. J. Pluznick. Johns Hopkins Univ. Sch. of Med. Tejada-Simon. Univ. of Houston. (707.8) 10:30 GPCRs as Regulators of Neutrophil Function. 11:35 Chronic Antagonism of p38α MAPK Normalizes Serotonin R. Corriden. UCSD. Clearance, Serotonin Receptor Hypersensitivity and 11:00 Orphan GPCRs and Psychiatric Disorders: GPR88. B. Social Behavior Deficits in a Genetic Murine Model Kieffer. McGill Univ. of Autism Spectrum Disorder. M.J. Robson, M.A. 11:30 The Extent of Vascular Remodeling Is Dependent Quinlan, J. Veenstra-VanderWeele, D.M. Watterson, on the Balance between ERα and GPER(GPR30). R.D. Blakely Vanderbilt Univ., Columbia Univ. and R. Gros, Q. Ding, Y. Hussain, J. Chorazyczewski, Northwestern Univ., Chicago. (707.9) G. Pickering, R.D. Feldman. Western Univ. and 11:50 Panel Discussion. Memorial Univ. of Newfoundland, Canada. (1189.1) 57 PHARMACOLOGY SUNDAY

11:45 Identification of a First-In-Class Adhesion G Protein- 10:15 The Role of the Ubiquitin-Proteasome System in Coupled Receptor Orthosteric Antagonist. Neurodegenerative Disease. H.L. Paulson. Univ. of H. Stoveken, A. Smrcka, G.G. Tall. Univ. of Rochester Michigan Hlth. Syst. Med. Ctr. (709.5) 10:45 Clinical Development of MDM2 E3 Ligase Antagonists in Cancer Treatment. G.L. Nichols. Roche Pharma 172. DRUGS OF ABUSE AND ANTIRETROVIRALS: Res. and Early Develop. INTERACTIONS AND TOXICITIES 11:15 Targeting Degradation of Regulator of G Protein Signaling Proteins in Therapeutics. B. Sjogren. Symposium Michigan State Univ. 11:45 Ubiquitin Plays an Atypical Role in GPCR-Induced p38 (Sponsored by: The Division for Drug Metabolism) MAP Kinase Activation on Endosomes. N. Grimsey, (Cosponsored by: The Divisions for Neuropharmacology, R. Narala, B. Aguilar, C. Rada, T. Smith, A. Soohoo, Toxicology, Pharmacology Education, and M. Puthenveedu, V. Nizet, J.J. Trejo. UCSD. (1266.2) Molecular Pharmacology) 174. UNDERGRADUATE RESEARCH: CULTIVATING Sun. 9:30 am—San Diego Convention Center, Room 17A THE NEXT GENERATION OF RESEARCHERS Cochaired: S. Kumar and K. Jordan-Sciutto THROUGH SURF AND BEYOND

Drug Metabolism Symposium

Neurobiology Sun. 9:30 am—San Diego Marriott Marquis & Marina 9:30 Antiretroviral Drugs Induce Oxidative Stress and Hotel, San Diego Ballroom B

Neuronal Damage in the Central Nervous System. Cochaired: C. Fry, C.M. Davis and L. Aleksunes K. Jordan-Sciutto. Univ. of Pennsylvania. 9:55 Drug-Drug Interactions in HIV-Infected Patients Who Education Have Other Comorbid Conditions. W. Royal. Univ. of 9:30 Introduction and Overview. C. Fry. ASPET. Maryland Sch. of Med. 9:45 Faculty Perspectives on Undergraduate Research: 10:20 Differential Drug Interactions Between Antiretroviral Strategies, Successes, and Challenges. Drugs and Methamphetamine in Human and Rhesus S. Tsirka. Stony Brook Univ. Med. Sch. Monkey. A. Kumar. Univ. of Missouri-Kansas City. K. Murnane. Mercer Univ. 10:45 Interactions of HIV and Drugs of Abuse: The Importance L. Aleksunes. Rutgers Univ. of Glia, Neural Progenitors, and Host Genetic Factors. 10:30 Student Perspectives on Undergraduate Research: P. Knapp. Virginia Commonwealth Univ. Benefits, Challenges, and Next Steps. 11:10 Drug Interactions and Toxicity between ART and Alcohol M. Little. Univ. of North Carolina at Chapel Hill. in Monocytes and Astrocytes: Implications with HIV C. Fearce. Spelman Col. Pathogenesis. S. Kumar. Univ. of Tennessee Hlth. N. Arabian. Univ. of Southern California. Sci. Ctr. 11:15 Interactive Table Discussions. 11:35 Tobacco Smoking and HIV Pathogenesis: Potential Role of Cytochrome P450 Pathway. P.S.S. Rao. Univ. of Findlay. 175. GOODMAN AND GILMAN AWARD IN RECEPTOR PHARMACOLOGY LECTURE 173. EMERGING ROLES FOR THE UBIQUITIN- Award Lecture PROTEASOME SYSTEM IN THERAPEUTICS Sun. 2:00 pm—San Diego Convention Center, Room 16AB Symposium The Louis S. Goodman and Alfred Gilman Award in (Sponsored by: The Division for Drug Discovery Receptor Pharmacology was established in 1980 to recognize and Development) and stimulate outstanding research in pharmacology of biological receptors, leading to a better understanding of the mechanisms (Cosponsored by: The Divisions for Molecular of biological processes and providing the basis for the discovery Pharmacology, Neuropharmacology, and Cancer of drugs useful in the treatment of diseases. Pharmacology ) 2:00 Introduction. Sun. 9:30 am—San Diego Convention Center, Room 17B 2:05 Towards an Atomic-Level Understanding of Psychoactive Cochaired: B. Sjogren and H.L. Paulson Drug Actions. Bryan Roth. Univ. of North Carolina at Chapel Hill. Drug Discovery and Development Cancer Biology Neurobiology 9:30 Introduction. 9:35 The Ubiquitin-Proteasome System in Health and Disease. R. Deshaies. HHMI and Caltech.

58 SUNDAY PHARMACOLOGY

176. ASPET PRESIDENTIAL SYMPOSIUM: PRECISION 178. DOSE SELECTION USING PHYSIOLOGICALLY MEDICINE IN ANTI-CANCER PHARMACOLOGY BASED MODELING

Symposium Symposium (Cosponsored by: The Divisions for Cancer (Sponsored by: The Division for Drug Metabolism) Pharmacology, Cardiovascular Pharmacology, and (Cosponsored by: The Division for Translational and Clinical Pharmacology) Pharmacology Education) Sun. 3:00 pm—San Diego Convention Center, Room 16AB Sun. 3:00 pm—San Diego Convention Center, Room 15A Cochaired: K.E. Thummel and S.P. Cole Chaired: J. Wahlstrom Cancer Biology Drug Metabolism S 3:00 Overview of Precision Medicine. K. Thummel. Univ. U 3:00 Introduction. of Washington. 3:05 Translation of Preclinical Information to Clinical Dose N 3:10 Pharmacogenomics: A Foundation of Precision Medicine Selection Using PBPK Approaches. H. Jones. Pfizer for Leukemia. W.E. Evans. St Jude Children’s Worldwide R&D. Res. Hosp. 3:35 Mechanistic Insights to the Prediction of Nonlinear 3:45 Genome-Wide Studies of Chemotherapeutic-Associated Pharmacokinetics. J. Wahlstrom. Amgen, Inc. Toxicities. M.E. Dolan. Univ. of Chicago. 4:05 Modeling and Simulation to Support Pediatric Drug 4:20 Use of Tumor Genomics to Customize Drug Treatment Development. A. Edginton. Univ. of Waterloo. in Women with Triple Negative Breast Cancer. 4:35 Predicting the Effects of Cytokine Modulation on C.A. Blau. Univ. of Washington. Pharmacokinetics Using PBPK. Y. Xu. Amgen, Inc. 4:55 Breast Cancer Pharmacogenomics: Application of PDX 5:05 Simulating Biodistribution and Pharmacokinetics for Model. L. Wang. Mayo Clin. Protein Therapeutics Using PBPK. P. Glassman. Univ. at Buffalo. 177. CANNABINOID SIGNALING IN PAIN AND ADDICTION: TRANSLATING PRECLINICAL 179. SEX DIFFERENCES IN CARDIOVASCULAR AND BASIC RESEARCH TO THE CLINIC RENAL PHARMACOLOGY Symposium Symposium (Sponsored by: The Division for Neuropharmacology) (Sponsored by: The Division for (Cosponsored by: The Divisions for Behavioral Cardiovascular Pharmacology) Pharmacology, Molecular Pharmacology, Drug (Cosponsored by: The Division for Discovery and Development, and Translational and Molecular Pharmacology) Clinical Pharmacology) Sun. 3:00 pm—San Diego Convention Center, Room 15B Sun. 3:00 pm—San Diego Convention Center, Room 17B Cochaired: S.H. Lindsey and E.Y. Gohar Cochaired: D. Morgan and J. Guindon Cardiovascular Pharmacology Neuropharmacology 3:00 Introduction. Neurobiology 3:05 Sex-Specific Immune Mechanisms in Vascular Disease. 3:00 Allosteric Modulators of Cannabinoid Receptor Function. K. Sandberg. Georgetown Univ. Med. Ctr. K. Mackie. Indiana Univ. 3:30 Double-Edged Sword: Sex Hormones in Renal Health. 3:30 Cannabidiol as an Anti-inflammatory/Analgesic and M. Zimmerman. Tulane Univ. Potential Anti-addictive Treatment. E. Russo. Phytecs. 3:55 Sexual Dimorphism in Nicotine Interaction with 4:00 Endocannabinoids in Circulation and Pain. C. Hillard. Baroreflex Control of Heart Rate. M. El-Mas. Med. Col. of Wisconsin. Alexandria Univ., Egypt. 4:30 Insights into the Mechanisms of Tolerance for 4:20 Sex Hormones and Vascular Protection: Clinical Cannabinoid Drugs. J. Guindon. Texas Tech Univ. Implications. F. Hage. Univ. of Alabama at Birmingham. Hlth. Sci. Ctr. 4:45 Sex Specific Differences in Key Signaling Pathways 5:00 Role of the Endocannabinoid System in Addiction. Involved in Sympathetic Nervous System Control R. Maldonado. Univ. Pompeu Fabra, Barcelona. within the Dorsal Medulla of Adult Sheep with Fetal Betamethasone Exposure. A.S. Hendricks, D.I. Diz, H.A. Shaltout, M.C. Chappell. Wake Forest Sch. of Med. (716.5) 5:00 Sex-Based Differences in the Aortic Function of UCD- T2DM Rats: A Novel Rat Model of Type 2 Diabetes Mellitus. F. Akther, S. Shaligram, M.D. Karimi, J.L. Graham, K.L. Stanhope, P.J. Havel, R. Rahimian. Sch. of Pharm., Univ. of Pacific and Univ. of California, Davis. (716.1)

59 PHARMACOLOGY SUNDAY

5:15 The Effects of Sex and Genotype on the Population Division Symposium Pharmacokinetics and Pharmacodynamics Modeling (Sponsored by: The Division for and Simulation of Low Dose Epinephrine and Cardiac Pharmacology Education) Output. A.R. Eugene, M. Joyner. Mayo Clin. (716.4) Sun. 3:00 pm—San Diego Marriott Marquis & Marina 180. FROM LIGANDS TO SIGNALING: RECENT Hotel, San Diego Ballroom B

ADVANCES IN ADHESION GPCR Cochaired: M.A. Simmons and R. Theobald, Jr. PHARMACOLOGY AND BIOLOGY Pharmacology Education Symposium Education (Sponsored by: The Division for Molecular Pharmacology) Participants are encouraged to bring their laptops to this (Cosponsored by: The Divisions for Drug Discovery workshop. Attendees will work through exercises in small groups and Development, Neuropharmacology, Cancer with the authors of the revised POPs (patient-oriented problem- Pharmacology, and Cardiovascular Pharmacology ) solving system) serving as facilitators.

Sun. 3:00 pm—San Diego Convention Center, Room 17A 3:00 A Brief History of the POPS and Presentation of Their Current Structure. M. Simmons. Univ. of Maryland Cochaired: X. Piao and R.A. Hall Eastern Shore. Molecular Pharmacology 3:15 Facilitated Exercises: Treatment of Essential Hypertension. M. Simmons. Cancer Biology Univ. of Maryland Eastern Shore. Treatment of Cardiac Arrhythmias. J. Yun. Northeast Neurobiology Ohio Med. Univ. 3:00 Signaling and Regulation of the BAI Subfamily of Drug Treatment of Heart Failure. R. Rockhold. Univ. of Adhesion GPCRs. R. Hall. Emory Univ. Sch. of Med. Mississippi Med. Ctr. 3:25 Structural Organization of the Extracellular Domains of Therapy of Diabetes Mellitus. J. Reuben. Univ. of South Adhesion GPCRs. D. Arac-Ozkan. Univ. of Chicago. Carolina Sch. of Med. Greenville. 3:50 Adhesion GPCRs are Turned on by Tethered Ligands. Treatment of Psychosis. G. Athauda. Florida Intl. Univ. T. Schöneberg. Univ. Leipzig. Drug Overdose Toxicity. R. Theobald, Jr. A.T. Still Univ. 4:15 Adhesion GPCR Activation by Tethered Agonist - Kirksville Col. of Osteo. Med. Decryption and Small Molecule Antagonism. G. Tall. 5:15 Summary and Discussion. R. Theobald, Jr. A.T. Still Univ. of Rochester Med. Ctr. Univ. - Kirksville Col. of Osteo. Med. 4:40 In Vivo Small Molecule Screens Define Modulators of Adhesion GPCR Signaling. S. Petersen. Washington 182. STUDENT/POSTDOC POSTER COMPETITION Univ. - St. Louis. 5:05 GPR56 and its Ligand in Oligodendrocyte Development Poster Award Competition and Myelination. X. Piao. Boston Children’s Hospital. Sun. 6:30 pm—San Diego Convention Center, 181. DIVISION FOR PHARMACOLOGY EDUCATION Ballroom 20BC SYMPOSIUM: MEET THE NEW POPS – THEY’LL ASPET Divisions award prizes to undergraduates, graduate FLIP YOUR TEACHING students, and postdocs making the best poster presentations at this event. Join us to view the top student/posdoc posters.

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60 SUNDAY PHYSIOLOGY Physiology

183. APS PRESIDENT’S SYMPOSIUM SERIES 9:30 Essential Involvement of Purinergic Signaling in PHYSIOLOGICAL MECHANISMS Calcium Handling in the Podocytes of Type 2 Diabetic RESPONSIVE TO BEHAVIORAL AND Rats. D. Ilatovskaya, O. Palygin, A. Lowing, V. ENVIRONMENTAL CHALLENGES Levchenko, J. Lazar, A. Staruschenko. Med. Col. of Wisconsin. (740.4) 9:45 Protective Role of AMPK in Sepsis Associated AKI. Y. Li, PHYSIOLOGICAL PROCESSES UNDERLYING N. Nourbakhsh, E. Hall, M. Hepokoski, H. Pham, ORGAN INJURY IN ALCOHOL ABUSE J. Thomas, P. Singh. UCSD and VA San Diego Healthcare Syst. (1217.18) Symposium S

Sun. 10:30 am—San Diego Convention Center, 185. MICROBIOME IN CARDIOPULMONARY U Ballroom 20A DISEASES: FROM ASSOCIATION N TO CAUSATION Chaired: G. Murray and F.M. Souza

10:30 Regulation of Protein Synthesis in Cardiac and Skeletal Symposium Muscle. C. Lang. Penn State Col. Med. (Sponsored by: APS Cardiovascular Section) 11:00 Adipose Tissue as a Target for Excess Alcohol Consumption. L. Nagy. Cleveland Clin. Fndn. Sun. 8:00 am—San Diego Convention Center, Room 26 11:30 Liver Mitochondrial Stress and Energy Metabolism. Chaired: V. Shenoy and J. Pluznick S. Bailey. Univ. of Alabama at Birmingham. 12:00 Role of the Endocannabinoid System in Mediating the Microbiome Neural Adaptations to Alcohol. L. Parsons. Scripps Res. Inst. 8:00 Non-Lethal inhibition of a Gut Microbial Pathway for the Treatment of Cardiovascular Disease. S. Hazen. Cleveland Clinic. 184. ADVANCES IN RENAL PHYSIOLOGY I 8:30 Impact of Microbial Alterations on Salt Sensitive Hypertension. B. Joe. Univ. of Toledo. Featured Topic 9:00 Gut Microbiota-Derived Signals and Blood Pressure (Sponsored by: APS Renal Section) Regulation. N. Natarajan. Johns Hopkins Univ. 9:30 Gut Microbial Dysbiosis in Pulmonary Hypertension: Sun. 8:00 am—San Diego Convention Center, Room 27 Impact and Opportunities. V. Shenoy. Univ. of Florida. Chaired: P.R. Grimm and P.S. Caceres 186. MUSCLE DYSFUNCTION IN DIABETES: Ion Transport CAUSE(S) OR EFFECT(S)? 8:00 Targeted Knockin of Constitutively Active SPAK in the Early Distal Convoluted Tubule (DCT1) Causes Featured Topic Hyperkalemic Hypertension. P.R. Grimm, R. (Sponsored by: APS Muscle Biology Group) Coleman, E. Delpire, P.A. Welling. Univ. of Maryland Sch. of Med. and Vanderbilt Univ. Med. Sch. (967.10) Sun. 8:00 am—San Diego Convention Center, Room 25C 8:15 Role of the Novel Kinase TNIK on NKCC2 Surface Expression, Phosphorylation and Na Reabsorption in Chaired: J. Brozinick the Thick Ascending Limb. P.S. Caceres, P.A. Ortiz. 8:00 Chair’s Introduction. Henry Ford Hosp. and Wayne State Univ. (967.12) 8:15 Alterations in Muscle Metabolism from Exercise Trained 8:30 Knockout of Na-Glucose Transporter SGLT1 Lowers Diabetic Humans. J. Zierath. Karolinska Univ. GFR and Kidney Weight in Non-diabetic and Akita 8:30 Improved Insulin-Mediated Glucose Oxidation in Diabetic Mice. P. Song, Y. Fu, A. Onishi, H. Qiu, Cultured Human Myotubes following Roux-en-Y H. Koepsell, V. Vallon. UCSD and VA San Diego Gastric Bypass Surgery. K. Zou, J.M. Hinkley, S. Healthcare Syst., Central South Univ., China and Inst. Park, D. Zheng, G.L. Dohm, J.A. Houmard. East of Anat. and Cell Biol., Würzburg, Germany. (740.21) Carolina Univ. (770.4) 8:45 T Cell Infiltration in Kidney Induces Salt-Retention via 8:45 Higher Cell Growth/Viability Accompanied by Reduced NCC Up-Regulation. S. Mu, Y. Liu. Univ. of Arkansas Myosin Heavy Chain Expression in Skeletal Muscle for Med. Sci. (966.4) Cells Derived from Severely Obese Type 2 Diabetic 9:00 The cGMP/PKG Signaling Pathway Underlies the Humans. K.D. Turner, K. Zou, M. Hinkley, S. Park, D. Inhibitory Effect of Sildenafil Citrate on NHE3 Activity Zheng, J. Houmard. East Carolina Univ. (770.5) in Rat Renal Proximal Tubules. P.M.C. dos Santos, 9:00 The Role of Ankrd2 in Obesity-Induced Inflammation T.D. Pessoa, G. Malnic. Univ. of São Paulo. (967.14) and Insulin Resistance. A.M. Hernandez-Carretero, 9:15 Internalization of Angiotensinogen in Renal Proximal N. Weber, N.Y.T. Doan, O. Osborn. UCSD and Tubules: Evidence for Mitochondrial Trafficking. Pomona Col., CA. (770.3) B. Wilson, N. Cruz-Diaz, Y. Su, J.C. Rose, M.C. Chappell. Wake Forest Sch. of Med. (967.5)

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9:15 Obesity Distinctly Influences Cardiac Function and 188. NEURAL AND HORMONAL MODULATION OF Molecular Responses to Ischemia-Reperfusion FLUID BALANCE AND ION HOMEOSTASIS IN and GLP-1 Receptor Agonism. D.J. Sassoon, A.G. HEALTH AND DISEASE Goodwill, J.N. Noblet, A.M. Conteh, B.P. Herring, J. McClintick, J.D. Tune, K.J. Mather. Indiana Univ. Featured Topic Sch. of Med. (770.1) 9:30 Myostatin Inhibition as an Adjuvant Therapy in Type (Sponsored by: APS Water and Electrolyte 1 Diabetes Mellitus. T.J. Hawke, S. Coleman, Homeostasis Section) I. Rebalka, D. D’Souza, N. Deodhare. McMaster Sun. 8:00 am—San Diego Convention Center, Room 25A Univ., Canada. (770.2) Chaired: C. Banek and H. Lob

187. NCAR YOUNG INVESTIGATOR AWARDS 8:00 Vasopressin Receptor Regulation in Maintaining Potassium Homeostasis in a Sus scrofa Model of Featured Topic Hemorrhagic Shock. C.F.T. Uyehara, L.N. Kajiura, (Sponsored by: APS Neural Control and Autonomic L-A.M. Murata, S.A. Wong, W.M. Ichimura, C.A. Regulation Section) Hernandez, J. Sarkar, M.R. Rowland. Tripler Army Med. Ctr., HI. (962.1) Sun. 8:00 am—San Diego Convention Center, Room 22 8:15 High Salt Activation of Collecting Duct-Derived Nitric Chaired: R. Ramchandra and R. Sabharwal Oxide Synthase Suppresses the Renin-Angiotensin- Aldosterone System. J.S. Pollock, D.M. Pollock, Neurobiology C. Dugas, K.A. Hyndman. Univ. of Alabama at Birmingham. (962.5) Neurophysiology 8:30 Salt and Angiotensin II Treatment Induces Fluid 8:00 Sympathetic Overactivity: The Missing Link in Non- Congestion and Heart Failure with Increased Mortality alcoholic Fatty Liver Disease? C. Young. George in Balb/C Mice but Not in C57BL/6J. S.T. Joensson, M. Washington Univ. Becriovic-Agic, M. Hulström. Uppsala Univ. (962.6) 8:30 Norepinephrine-Mediated Suppression of T-Lymphocyte 8:45 Chronic Vagus Nerve Stimulation Attenuates Renal Activation Is Regulated by Mitochondrial Redox Inflammation in Autoimmune-Induced Hypertension. Mechanisms. A.J. Case, M.C. Zimmerman. Univ. of G.S. Pham, A.S. Fairley, C.I. Maloy, K.W. Mathis. Nebraska Med. Ctr. (757.1) Univ. of North Texas Hlth. Sci. Ctr. (962.7) 8:45 Central Anti-inflammatory and Neuronal Effects 9:00 The Neuroimmune Axis in Hypertension. D. Harrison. of Butyrate in Wistar Kyoto and Spontaneously Vanderbilt Univ. Hypertensive Rats. T. Yang, V. Rodriguez, L. Colon- 9:30 Renal Denervation Normalizes Blood Pressure and Perez, T. Redler, M. Febo, C. Sumners, J. Zubcevic. Improves Glucose Metabolism in Obese Genetically Univ. of Florida. (757.2) Hypertensive Schlager Mice. N. Asirvatham-Jeyaraj, 9:00 Renal Nerves, Renal Inflammation and Hypertension in C.T. Banek, R. Han, M. Razzoli, B.J. Burbach, A. Deoxycorticosterone Acetate-Salt Hypertension: Who Bartolomucci, Y. Shimizu, J.W. Osborn. Univ. of Is in the Driver’s Seat? C.T. Banek, J.D. Foss, D.A. Minnesota, Minneapolis. (962.9) Van Helden, N. Asirvatham-Jeyaraj, J.W. Osborn. 9:45 Renal Afferent Nerve Modulation of Sodium Homeostasis Univ. of Minnesota, Minneapolis and Vanderbilt Univ. and Blood Pressure: A Sodium Sensitive Mechanism (757.3) Countering the Development of Salt-Sensitive 9:15 Renal Function in Normotensive Sheep in the First Hypertension? R.D. Wainford, K.R. Walsh, C.Y. Fourteen Weeks after Catheter-Based Renal Carmichael. Boston Univ. (962.3) Denervation. L.C. Booth, Z. McArdle, S.T. Yao, S. Malone, Y. Lankadeva, J. Kosaka, M. Schlaich, 189. NEW INSIGHTS INTO EXERCISE AND C.N. May. Florey Inst. of Neurosci. and Ment. Hlth. INSULIN SENSITIVITY and IDI Heart & Diabetes Inst., Melbourne. (757.4) 9:30 Neuronal Activation of ADAM17 by AT1A Receptors Symposium Contributes to Neurogenic Hypertension. J. Xu, S. Sriramula, E. Lazartigues. LSU Hlth. Sci. Ctr., (Sponsored by: APS Endocrinology and New Orleans. (757.5) Metabolism Section) 9:45 Prostaglandin E and Its EP3 Receptors Contribute 2 Sun. 8:00 am—San Diego Convention Center, Room 23 to Dendritic Cell and Memory T Cell Activation in Mice with L-NAME/High Salt-Induced Hypertension. Chaired: E. Richter and G. McConell L. Xiao, H.A. Itani, M.P. Kraemer, R.M. Breyer, D.G. Harrison. Vanderbilt Univ. (757.6) Metabolism and Metabolic Disease Skeletal Muscle Physiology 8:00 Introduction and Role of Rac1 in insulin Sensitivity After Exercise. E. Richter. Univ. of Copenhagen. 8:30 The Role of AMPK in Insulin Sensitivity after Exercise. J. Wojtaszewski. Univ. of Copenhagen.

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9:00 The Role of Skeletal Muscle Microvascular Flow in 192. TRAINEE HIGHLIGHTS IN Contraction and Insulin-Stimulated Glucose Uptake. PHYSIOLOGICAL GENOMICS M. Keske. Menzies Inst. for Med. Res., Univ. of Tasmania. Featured Topic 9:30 The Role of Nitric Oxide in the Insulin Sensitizing Effects of Exercise. G. McConell. Victoria Univ. Sun. 8:00 am—San Diego Convention Center, Room 28A Chaired: A. Kriegel and H. Cai 190. PHYSIOLOGICAL AND PATHOLOGICAL ASPECTS OF 8:00 Deficiency in the Anti-aging Gene Klotho Promotes Aortic Valve Fibrosis through AMPK -Mediated HYPERTROPHIC CARDIOMYOPATHY α Activation of RUNX2. J. Chen, Y. Lin, Z. Sun. Univ. of Oklahoma Hlth. Sci. Ctr. (1260.7) Symposium 8:15 Exercise Training in the Metabolic Syndrome S (Sponsored by: APS Cardiovascular Section) Improves Perivascular Adipose Gene Expression. U E. DeVallance, K. Branyan, K. Lemaster, R. Skinner, N Sun. 8:00 am—San Diego Convention Center, Room 24 S. Brooks, W. Sheets, R. Bryner, J. Frisbee, Chaired: S. Steinberg and S. Sadayappan P. Chantler. West Virginia Univ. (771.9) 8:30 Phosphorylation of α-Actinin-4 at Serine 159 Mimics the Myocardial Infarction/Heart Failure Biochemical and Cellular Effects of Human Kidney 8:00 Cardiac Remodeling by Redox-Activated Protein Kinase Disease Mutations. D. Feng, R. Krishnan, L. Stella, C-delta. S. Steinberg. Columbia Univ. M. Schenone, C.R. Hartigan, M.R. Pollak. Beth 8:30 The Importance of the Ubiquitin Proteasome System Israel Deaconess Med. Ctr. and Havard Med. Sch., in Hypertrophic Cardiomyopathy Associated Univ. of Rome Tor Vergata and Broad Inst. of Harvard with Troponin Mutations. A. Gomes. Univ. of and MIT. (771.1) California, Davis. 8:45 MiR9 Is Increased in Monocytes 9:00 Ca2+ Sensitizing TroponinT Mutations Alter Coronary and Regulates Monocyte Migration. J. Gaudette, Perfusion and Cardiac Energetics. S. Huke. W.A. Stinson, D.A. Fox, M.A. Amin, B.J. Rabquer. Vanderbilt Univ. Albion Col. and Univ. of Michigan. (1028.11) 9:30 Molecular Mechanism of Hypertrophic Cardiomyopathy 9:00 Fruit and Vegetable Intervention Lowers Circulating in Populations of South Asian Descendants. Ceramide Levels and Improves Estimated Insulin S. Sadayappan. Loyola Univ. Chicago. Sensitivity in Young Adults at Risk of Developing Metabolic Syndrome: A FRUVEDomic Pilot Study. A.T. Mathews, O.A. Famodu, M.D. Olfert, P.J. 191. STANDING ON THE EDGE: Murray, C.F. Cuff, M.T. Downes, N.J. Haughey, S.E. TRANSFORMATIONAL TEACHING AND Colby, I.M. Olfert, J.W. McFadden. West Virginia LEARNING BEYOND THE CLASSROOM WALLS Univ., John Hopkins Univ. and Univ. of Tennessee, Knoxville. (1260.3) Symposium 9:15 The MicroRNA let-7f Regulates Expression of the (Sponsored by: APS Teaching of Physiology Section) Voltage-Gated Mechanosensitive Ion Channel NaV1.5 in Human Gastrointestinal Smooth Muscle. Sun. 8:00 am—San Diego Convention Center, Room 25B A. Mazzone, P.R. Strege, C.E. Bernard, R.R. Cima, D.W. Larson, E.J. Dozois, Y. Hayashi, T. Ordog, Chaired: A.R. Crecelius and J.C. Taylor S.J. Gibbons, A. Beyder, G. Farrugia. Mayo Clin. Education (1028.10) 9:30 Altered DNA-Damage/BRD4 Signaling Pathways in the 8:00 Always a Teacher, Always a Student. M. Joyner. Lungs of Patients with Pulmonary Hypertension Can Mayo Clin. Propagate to the Coronary Vasculature and Induce 8:30 Speaking English, Speaking Science: Undergraduates Coronary Artery Disease. J. Meloche, V. Nadeau, E. Show Language Learners the PhUn of Physiology. Tremblay, F. Potus, S. Chabot, E. Charbonneau, P. Halpin. Univ. of New Hampshire Manchester. S. Provencher, S. Bonnet. Laval Univ., Canada. 8:50 Experiential Learning in Exotic Locations A. Bunker. (1260.9) Morningside Col., IA. 9:45 Deletion of the Prorenin Receptor in the Collecting 9:10 Citizen Science: Public Participation in the Research Duct Impairs Renal Function and Attenuates Blood Process. N. Garneau. Denver Museum of Nature Pressure in Chronic Angiotensin II-Infused Mice. and Sci. V. Reverte Ribo, V.R. Gogulamudi, A.A. Gonzalez, 9:30 Panel Discussion. C.B. Rosales, M.R. Gallaty, A. Castillo, A. Ichiara, L.G. Navar, M.C. Prieto. Tulane Univ., Pontifical Catholic Univ.of Valparaíso, Chile and Kumamoto Univ., Japan. (1260.1)

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193. TRANSLATIONAL PHYSIOLOGY SHOWCASE: 9:06 Exposure to a Diet High in Saturated-Fat during Pre- FOCUS ON THE EFFECTS OF ALCOHOL natal and Post-weaning Brain Development Alters ABUSE, BEHAVIOR, DIET, NUTRITION, AND Hippocampal Gene Expression and Behavioral EXTREME ENVIRONMENTAL CONDITIONS Indices for Anxiety and Depression. K.C. Page, M.E. Winkelmann, E.K. Anday. Bucknell Univ. and Drexel ON PHYSIOLOGY Univ. Col. of Med. (749.7) 9:13 Enhanced Dietary Fructose Rapidly Induces Salt- Featured Topic Sensitive Hypertension in Rats. K.L. Gordish, P.A. (Sponsored by: APS Translational Physiology Ortiz, J.L. Garvin, W.H. Beierwaltes. Henry Ford Interest Group) Hosp. and Case Western Reserve Univ. (1216.1) 9:19 Round Table Discussion. Sun. 8:00 am—San Diego Convention Center, Room 28B

Chaired: C.N. Young and B.T. Bikman Topics in Extreme Environmental Conditions

8:00 Introduction to talks and format. 9:27 Maternal Chronic Intermittent Hypoxia during Gestation Programs Hypercholesterolemia in the Offspring. Topics in Alcohol Abuse J. Ciriello, W. Iqbal, D. Hardy. Univ. of Western Ontario. (1247.14) 8:03 Downregulation of Hepatic ecto-5′-Nucleotidase 9:34 Chronic Heat Preconditioning Enhances Skeletal (CD73) in a Mouse Model of Alcoholic Liver Injury Muscle Function during Hypoxia and Reoxygenation. and in Patients with Alcoholic Steatohepatitis. L. Zuo, W.J. Roberts, B.K. Pannell. The Ohio State M.L. Richardson, H.H. Willcockson, G. Odena, Univ. and Oakland Univ., MI. (1245.17) R. Bataller, N. Snider. Univ. of North Carolina at 9:41 Kidney Injury Marker-1: A Potential Point-of-Care Chapel Hill. (1249.7) Biomarker of Heat Stress. G.N. Audet, J.A. Ward, 8:10 In Utero Exposure to Alcohol Alters Reactivity of S.M. Dineen, S.N. Cheuvront, L.R. Leon. U.S. Army Cerebral Arterioles. S.G. Cananzi, W.G. Mayhan. Res. Inst. of Envrn. Med., Natick, MA. (1243.3) LSU Hlth. Sci. Ctr., Shreveport. (953.14) 9:48 Control of Lung Ventilation after Extended Disuse 8:17 Claudin-5 Decreases Alveolar Barrier Function in Caused by Overwintering Submergence in the Bullfrog. Alcoholic Lung Syndrome by Displacing Claudin-18 J. Santin, L. Hartzler. Wright State Univ. (760.24) from Tight Junctions. B.L. Schlingmann, S. Dorsainvil 9:54 Round Table Discussion. White, S. Molina, K.S. Lynn, C.T. Capaldo, M. Koval. Emory Univ., Sch. of Med. Emory Univ. (1264.6) 194. BRIDGING THE GAP BETWEEN PRE-CLINICAL 8:24 Tolerance to Alcohol-Stimulated Glutamate Receptor AND CLINICAL EVIDENCE: TREATING Phosphorylation in the Central Amygdala and Prefrontal Cortex after Chronic Nicotine Exposure. CARDIOVASCULAR DISEASES WITH M.A. McGinn, C.A. Itoga, R.I. Paulsen, J.E. Reppel, AUTONOMIC MODULATION THERAPIES M.A. Farooq, N.W. Gilpin, S. Edwards. LSU Hlth. Sci. Ctr., New Orleans. (992.5) Symposium 8:30 Round Table Discussion. (Sponsored by: APS Neural Control and Autonomic Regulation Section) Topics in Behavior, Diet and Nutrition Sun. 10:30 am—San Diego Convention Center, Room 26 8:38 Distribution Pattern of Dietary Protein Intake Does Not Affect Anabolic Response, Lean Body Mass, Chaired: S. Ruble and K. Sunagawa Muscle Strength or Function Over 8 Weeks in Older Neurobiology Adults I-Y. Kim, S. Schutzler, G. Azhar, R. Wolfe, A. Ferrando. Univ. of Arkansas for Med. Sci. (1016.2) Hypertension - 8:45 Dietary Nitrate (NO3 )-Induced Increases in Skeletal Muscle Contractile Function: High versus Low Myocardial Infarction/Heart Failure Responders. A.R. Coggan, D. Mikhalvkova, K. 10:30 Deep Brain Stimulation for Hypertension. A. Green. Mahmood, I. Bole, J. Leibowitz, A. Kadkhodayan, Oxford Univ. S. Park, D. Thomas, D. Thies, L.R. Peterson. 11:00 Carotid Sinus Stimulation for Hypertension. J. Tank. Washington Univ. Sch. of Med. (1245.28) Hannover Med. Sch., Germany. 8:52 Maternal Protein Intake as a Determinant of the Total 11:30 Vagal Nerve Stimulation for the Treatment and Number of Motor Units and Muscle Fibres in Mice. Prevention of Heart Failure. K. Saku. Kyushu A. Vasilaki, I. Giakoumaki, N. Pollock, K. Goljanek- Univ., Japan. Whysall, A. McArdle, A.A. Sayer. Univ. of Liverpool 12:00 Vagal Nerve Stimulation for Arrhythmias. A. Talkachova. and Newcastle Univ. (1009.10) Univ. of Minnesota. 8:59 Metabolic Dysfunction Induced by Prenatal Exposure to Bisphenol-A and Diethyl Hexyl Phthalate: Exacerbation by High Fat Diet. C.K. Hahn-Townsend, P.A. Varde, P.S. MohanKumar, S.M. MohanKumar. Univ. of Georgia and Michigan State Univ. (1293.6)

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195. CLAUDE BERNARD DISTINGUISHED 197. MACROPHAGES: A DOUBLE-EDGED SWORD IN LECTURESHIP OF THE APS TEACHING OF INFLAMMATORY TISSUE INJURY PHYSIOLOGY SECTION Symposium Lecture (Sponsored by: APS Respiration Section) (Sponsored by: APS Teaching of Physiology Section) Sun. 10:30 am—San Diego Convention Center, Room 25C Sun. 10:30 am—San Diego Convention Center, Room 24 Chaired: D. Mehta and F.R. D’Alessio Education Inflammation/Immunity An Evolution in Student-Centered Teaching. 10:30 Macrophage Plasticity and Lung inflammation. B. Goodman. Univ. of South Dakota Sanford Sch. B. Moore. Univ. of Michigan Med. Sch. S of Med. 10:55 Engulfment of Pathogens and Their Ligands by U Phagocytosis and Macropinocytosis. S. Grinstein. N 196. EPITHELIAL PHYSIOLOGY AND TRANSPORT I Univ. of Toronto. 11:20 Communication between Macrophages and Featured Topic Alveolar Barrier Regulates Lung inflammation. (Sponsored by: APS Epithelial Transport Group) J. Bhattacharya. Columbia Univ. Col. of P&S. 11:45 Macrophage Reprogramming Accelerates Ali Resolution Sun. 10:30 am—San Diego Convention Center, Room 28A and Lung Repair. N. Aggarwal. Johns Hopkins Univ. Chaired: J. Bomberger and N. Bradbury 12:10 S1P-Generating Macrophages and Lung Vascular Barrier Regulation. D. Mehta. Univ. of Illinois Sch. of Med. Microbiome Ion Transport 198. METABOLIC SYNDROME AND THE PATHWAY OF DRUG DEVELOPMENT: FROM BENCH Barriers: Endothelium and Epithelium TO BEDSIDE 10:30 Hans Ussing Lecture. CFTR Cl Channels and Cystic Fibrosis. B. Stanton. Dartmouth Univ. Symposium 11:15 Inducible Renal Tubule-Specific Insulin Receptor (Sponsored by: APS Physiologists in Industry Committee) Knockout Mice Have Decreased NCC-Mediated Sodium Reabsorption and Reduced Sensitivity to Sun. 10:30 am—San Diego Convention Center, Room 23 Mineralocorticoid-Induced Hypertension in Obesity Chaired: M.R. Zahner and D.C. Cornelius and Insulin Resistance. J.M. Nizar, E.M. Walczak, W. Dong, L. Bankir, V. Bhalla. Stanford Univ. and Metabolism and Metabolic Disease Cordeliers Res. Ctr., INSERM, Paris. (968.1) 11:30 Salt-Losing Nephropathy in Mice with a Null Mutation of 10:30 The Potent Effects of Bariatric Surgery as a Platform for Clcnkb. A. Grill, I.M. Schiessl, A. Hammer, H. Castrop. Developing New Therapies for Obesity and Diabetes. Inst. of Physiol, Regensburg, Germany. (968.2) R. Seeley. Univ. of Michigan. 11:45 Down-Regulation of Kir4.1 Eliminates the Basolateral 11:00 Signaling without Barriers: Integrated Roles for individual K Conductance in the Distal Convoluted Tubule and Peptide Neurotransmitters in the Regulation of Inhibits NCC Activity. X-T. Su, M-X. Wang, P. Wu, J.A. Cardiovascular, Metabolic and Neuroendocrine McCormick, D.E. Ellison, W-H. Wang. New York Systems. A. Furguson. Queens Univ. Sch. of Med. Med. Col. and Oregon Hlth. & Sci. Univ. (968.3) 11:30 Bridging Cardiovascular Safety Pharmacology into the 12:00 Tight Junction Protein Abundance Is Altered in Clinical Realm. H. Vargas. Amgen. Metformin-Treated Airway Epithelial Cells. K.K. Kalsi, 12:00 Clinical Trials: Navigating the Clinical Phases from FIH J.P. Garnett, E.H. Baker, D.L. Baines. St. George’s to Post-marketing and the Regulatory Processes to Univ. of London and Newcastle Univ., U.K. (968.4) Market a Product. C. Mesner. Pfizer, Inc. 12:15 Hydrocortisone Affects the Transport Phenotype of Differentiated Normal Human Bronchial Epithelial Cells. 199. MICROBIOTA OR NUTRITION AND HOST N. Zaidman, A. Panoskaltsis-Mortari, S.M. O’Grady. CELL SIGNALING Univ. of Minnesota, Minneapolis and St. Paul. (968.5) Featured Topic (Sponsored by: APS Cell and Molecular Physiology Section)

Sun. 10:30 am—San Diego Convention Center, Room 25A

Chaired: R. Worrell and M. Butterworth

Microbiome 10:30 Coxiella burnetii Infection of Host Cells Involves PKC Substrate MARCKS. S. Whitlock, C.J. Funk. John Brown Univ. (744.3)

65 PHYSIOLOGY SUNDAY

10:45 Mechanism of Action of Lactobacillus reuteri ATCC PTA 201. RENAL SECTION YOUNG INVESTIGATOR 6475 in Colon Epithelial Cells. N.D. Rios-Arce, R.A. SYMPOSIUM: NOVEL SIGNALING AND Britton, L. McCabe, N. Parameswaran. Michigan TRANSPORT MECHANISMS IN THE State Univ. and Baylor Col. of Med. (744.5) COLLECTING DUCT 11:00 Comparative Analysis of Biotransformation of trans- Resveratrol in Worms, Flies, Mice and Humans. Featured Topic S.E. Kulling, S.T. Soukup, F. Rieck, B. Spanier, C. Schulze, S. Piegholdt, G. Rechkemmer, A.E. (Sponsored by: APS Renal Section) Wagner, A. Bub, G. Rimbach, H. Daniel. Max Sun. 10:30 am—San Diego Convention Center, Room 27 Rubner Inst., Karlsruhe, TU München and Univ. of Kiel, Germany. (744.2) Chaired: M.C. Prieto-Carrasquero and J. Peti-Peterdi 11:15 Indigenous Bacteria from the Gut Microbiota Regulate Host Serorotonin Biosynthesis. E. Hsiao. California 10:30 Renal Section Young Investigator Award Lecture. Inst. of Technology. M. Prieto. Tulane Univ. Sch. of Med. 11:45 Interplay between Nutrition and Environment in Altering 11:00 Lack of the Prorenin Receptor in the Collecting Duct the Gut Microbiome and Susceptibility to Type 2 Blunts the ENaC Responses to Chronic Angiotensin II. Diabetes. M. Schaid, J. Neuman, J. Wisinski, A. A.A. Gonzalez, V. Reverte-Ribo, A. Katsurada, C.B. Reuter, E. Laundre, R. Fenske, M. Kimple. Univ. of Rosales, M. Galatty, M. McLellan, O. Gentile, L.C. Wisconsin-Madison. (744.1) Veiras, D.M. Seth, A. Ichihara, A.A. Mc Donough, 12:00 EriC2 Regulates Histamine Production Machinery via an M. Mamenko, O.M. Pochynyuk, L.G. Navar, M.C. Ion Transport-Dependent Mechanism in Lactobacillus Prieto. Pontifical Catholic Univ. of Valparaíso, Chile, reuteri. A. Hall, M. Engevik, J. Versalovic. Baylor Tulane Univ., Tokyo Women’s Med. Univ., Keck Sch. Col. of Med. and Texas Children’s Hosp. (744.6) of Med. of USC and Univ. of Texas Hlth. Sci. Ctr. at 12:15 Renal Olfactory Receptor 90 Responds to Fungal Houston. (741.1) + Metabolites. V.L. Halperin Kuhns, J.L. Pluznick. 11:15 High K Intake Attenuates ARPKD Progression by 2+ Johns Hopkins Univ. (744.4) Activation of TRPV4-Mediated Ca Signaling in Cyst Cells. M. Mamenko, V. Tomilin, O. Zaika, O. Pochynyuk. Univ. of Texas Hlth. Sci. Ctr. at Houston. 200. OMICS APPLICATIONS IN (741.10) METABOLIC PHYSIOLOGY 11:30 EHD4 Deletion Results in a Urine Concentrating Defect in Mice. S.S. Rahman, A.E.J. Moffitt, M. Storck, Symposium H. Band, E.I. Boesen. Univ. of Nebraska Med. Ctr. (Sponsored by: APS Physiological Genomics Group and (741.7) The American Society for Nutrition) 11:45 ENaC in Renal Cortical Collecting Duct Principal Cells Is Stimulated by Increasing Intracellular Ca2+ in the Sun. 10:30 am—San Diego Convention Center, Room 25B Basal Compartment of the Cell via a Process Involving Chaired: M. Olfert and S. Adams Src but Not CAMK II. T.L. Thai, L. Yu, M.M. Wu, L.I. Galarza-Paez, B.J. Duke, O. Al-Khalili, H. Ma, D.C. 10:30 Metabolomics and the Physiology of Exercise and Eaton. Emory Univ. (741.3) Insulin Resistance. S. Adams. Univ. of Arkansas for 12:00 Lack of Adenylyl Cyclase 6 Induces Alkalosis and Med. Sci. Enhances Urinary Acidification. S.B. Poulsen, R.A. 11:00 The Sphingolipidome and Insulin Resistance: Fenton, T. Rieg. Aarhus Univ., Denmark, VA San Perspectives Gained from Studying the Overweight Diego Healthcare Syst. and UCSD. (741.6) Dairy Cow Transitioning From Gestation to Lactation. 12:15. (Pro)Renin Receptor Mediates Antidiuretic Action of

J. McFadden. West Virginia Univ. Vasopressin/Prostaglandin EP4 Subtype. T. Yang, 11:30 Genes, Exercise and Angiogenesis: Implications for the X. Lu, K. Peng, F. Wang. Univ of Utah. (741.5) Metabolome. M. Olfert. West Virginia Sch. of Med. 12:00 Metabolic Processes and Physiological Parameters Involved with the Ischemia/Reperfusion Protective Phenotype in Hibernators. L.K. Bogren, A. D’alessandro, T.G. Nemkov, K.C. Hansen, S.L. Martin. Univ. of Colorado Anschutz Med. Campus, Aurora. (1260.2) Are You Tweeting about 12:15 Depletion of Dietary microRNAs from Cow’s Milk Causes an Increase of Purine Metabolites in Human EB 2016? Body Fluids and Mouse Livers. A. Aguilar Lozano. Univ. of Nebraska, Lincoln. To Tweet use #expbio

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66 SUNDAY PHYSIOLOGY

202. THE SPINAL CONTROL OF MOTOR OUTPUT: 204. HUGH DAVSON DISTINGUISHED LECTURESHIP FROM NEURAL CIRCUITS TO MECHANICS OF THE APS CELL AND MOLECULAR PHYSIOLOGY SECTION Symposium Lecture (Sponsored by: APS Central Nervous System Section) (Sponsored by: APS Cell and Molecular Sun. 10:30 am—San Diego Convention Center, Room 28B Physiology Section) Chaired: A. Frigon and T.R. Nichols Sun. 2:00 pm—San Diego Convention Center, Room 24 Neurobiology Inflammation/Immunity Neurophysiology Myocardial Infarction/Heart Failure S 10:30 Start and Stop: A Matter of Excitation. O. Kiehn. GPCRomics: Discovering New Ways Cells Communicate U Karolinska Inst. with One Another and the Outside World. P. Insel. UCSD. 11:00 Reverse Engineering of Motor Output to Identify N the Synaptic Organization of Motor Commands. C. Heckman. Northwestern Univ. 205. CHEMICAL CONTROL OF AUTONOMIC 11:30 The Spinal Control of Left-Right Coordination from FUNCTION IN HEALTH AND DISEASE Simple to Extreme Conditions. A. Frigon. Univ. of Sherbrooke. Featured Topic 12:00 Locomotor CPG and Speed-Dependent Gait Control: Insights from Computational Modeling. I. Rybak. (Sponsored by: APS Hypoxia Group) Drexel Univ. Sun. 3:15 pm—San Diego Convention Center, Room 22

203. WIGGERS AWARD FEATURED TOPIC Chaired: H. Forster and C. Muere Oxidative Stress Featured Topic Neurobiology (Sponsored by: APS Cardiovascular Section) Hypertension Sun. 10:30 am—San Diego Convention Center, Room 23 3:15 Lahiri-Cherniack Lecture Human Adaptability to Chaired: G. Meininger Hypoxia: A Mixed Blessing. J. Dempsey. Univ. 10:30 Tandem Regulation of Vascular Smooth Muscle of Wisconsin-Madison. Contraction with Adhesion. G. Meininger. Univ. of 4:00 The Effect of Obese Levels of Leptin on Peripheral Missouri, Columbia. Chemoreception. R.L. Pye, A. Roy, R.J.A. Wilson, 11:00 Mechanisms for Aortic Stiffness and Consequent C.N. Wyatt. Wright State Univ. and Univ. of Calgary, Cardiovascular Disease with Aging. K. Morgan. Canada. (983.1) Boston Univ. 4:15 Characterization of Ectonucleotidase Expression in the 11:30 Smooth Muscle Cell Mineralocorticoid Receptors in Rat Carotid Body: Potential Regulation by Hypoxia? Vascular Fibrosis and Aging. I. Jaffe. Tufts Med. Ctr., S. Salman, C. Vollmer, C.A. Nurse. McMaster Univ., Tufts Univ. Sch. of Med. Canada. (983.2) 12:00 Coronary Microvascular Smooth Muscle-Endothelial 4:30 Early Postnatal Exposure to Intermittent Hypoxia Results Cell Communication and Notch 3 Signaling in Type in Significant Alterations in White Matter Integrity in a 2 Diabetes. P.E. McCallinhart, O.E. Clark, M. Kanai, Rat Pup Model of Apnea of Prematurity. R. Darnall, X. B. Lilly, A.J. Trask. Nationwide Children’s Hosp. and Chen, C. Sirieix, L. Xia, B. Gimi. Dartmouth Geisel The Ohio State Univ. Col. of Med. (730.3) Sch. of Med. (983.3) 12:15 A Splice Variant of Smooth Muscle Myosin Phosphatase 4:45 Chronic Intermittent Hypoxia Suppresses Adult Regulatory Subunit Tunes Arterial Reactivity and Neurogenesis and Disrupts Synaptic Plasticity in Suppresses Response to Salt Loading. J. Reho, the Dentate Gyrus of the Hippocampus through a D. Kenchegowda, L.D. Asico, S. Fisher. Univ. of Pro-oxidant State. C.M. Pagan, M.A. Khuu, A.Z. Maryland Sch. of Med. (730.1) Christakis, J-M. Ramirez, A.J. Garcia III. Seattle Children’s Res. Inst. and Univ. of Washington. (983.4) 5:00 An Acute Sustained Hypoxic Stress Is Sufficient to Cause Respiratory Muscle Weakness in the Mouse. A.J. O’Leary, K.D. O’Halloran. Univiversity Col. Cork, Ireland. (983.5)

67 PHYSIOLOGY SUNDAY

206. COMPARATIVE AND EVOLUTIONARY 207. EARLY LIFE STRESS AND SEX-SPECIFIC PHYSIOLOGY TRAINEE-DRIVEN MANIFESTATIONS OF CARDIO-RESPIRATORY FEATURED TOPIC DYSFUNCTION: INSIGHT FROM MICROGLIAL CELLS Featured Topic Symposium (Sponsored by: APS Comparative and Evolutionary Physiology Section) Sun. 3:15 pm—San Diego Convention Center, Ballroom 20A Sun. 3:15 pm—San Diego Convention Center, Room 25B Chaired: C. Baldy and J.H. Dasinger Chaired: D. Warren and C. Ivy Sex Differences 3:15 Ecologically-Relevant Temperatures and Stress in Desert Pupfish. A. McKenna, K. McKenna, Exercise, Aging, and Disease S. Hillyard, F. van Breukelen. Univ. of Nevada, Las Vegas. (1229.4) Hypertension 3:30 Spinal Oxygen Sensors in Larval . 3:15 Do Sex Differences in Microglia in the Brain Impact I.J. Evanger, M.D. Reed, R.J.A. Wilson, Somatic Functions? M. McCarthy. Univ. of Maryland M. Dutschmann, B.E. Taylor, M.B. Harris. Univ. of Sch. of Med. Alaska Fairbanks, Univ. of Calgary, Canada and Univ. 3:45 Sex Differences in Hypertension: Menopause, of Melbourne. (1230.2) T Lymphocytes and Inflammation. H. Brooks. Univ. 3:45 Relative Blood Flow and Cardiac Output in Embryos of of Arizona. the Snapping Turtle Chelydra serpentina (Reptilia; 4:15 The Impact of Sex and Age on the Developmental Chelonia). M.R. Sartori, Z.F. Kohl, A.S. Abe, E.W. Programming of Blood Pressure. B. Alexander. Univ. Taylor, D.A. Crossley II. São Paulo State Univ., Rio of Mississippi Med. Ctr. Claro, Univ. of North Texas and Univ. of Birmingham, 4:45 Neonatal Stress and Sex-Specific Disruption of U.K. (1230.6) Respiratory Control Development: The Potential Role 4:00 Benefits of Being Small? The Scaling of Flight of Microglia. R. Kinkead. Laval Univ. Performance in Stingless Bees and Size-Dependent Scaling of Insect Flight Metabolism. M. Duell, J.F. 208. EMERGING MECHANISMS OF Harrison. Sch. of Life Sci., Arizona State Univ. THERMOREGULATION AND (760.14) 4:15 Amino Acids as Fates of Anoxia-Induced Lactate Loads METABOLIC CONTROL in the Painted Turtle. C.A. Hill, K.E. Yarasheski, D.E. Warren. Saint Louis Univ. and Sch. of Med., Symposium Washington Univ. St. Louis. (760.19) (Sponsored by: APS Environmental and Exercise 4:30 Elevated Carbon Monoxide Production in Marine Physiology Section) Mammals. M.S. Tift, J. St. Leger, T. Leuker, P.J. Ponganis. Scripps Instn. of Oceanography and Sun. 3:15 pm—San Diego Convention Center, Room 27 SeaWorld, La Jolla. (760.26) Chaired: T.L. Clanton and M. Periasamy 4:45 Deiodinase Type 3 Methylation Increases in Response to Thyroid Stimulating Hormone in a Fasting Adapted Environmental Stress . B. Martinez, N. Gemmell, D.E. Crocker, Metabolism and Metabolic Disease R.M. Ortiz. Univ. of California Merced, Univ. of Otago, New Zealand and Sonoma State Univ. (760.28) 3:15 Hot and Sweet: Human Brown Fat beyond 5:00 Respiratory Adaptations to High-Altitude Hypoxia Thermoregulation. P. Lee. Garvin Inst. Med. Res., in Deer Mice (Peromyscus maniculatus). C. Ivy, Darlington, NSW, Australia. G. Scott. McMaster Univ., Canada. (1230.3) 3:45 Muscle Beyond Contraction, Its Role in Thermogenesis and Metabolism. M. Periasamy. Sanford Burnham Prebys Medical Discovery Inst. 4:15 Which TRP Channels Drive Cold-Defense Responses in Rodents? A. Romanovsky. St. Joseph’s Hosp. and Arizona State Univ. Visit the Exhibits 4:45 Exercise and Neurodegeneration; Potential Therapeutic Role for FNsDC5/irisin. C. Wrann. Dana Farber Inst., April 3–April 5 Harvard Univ. Med. Sch. Exhibit Hours Sunday–Tuesday 9:00 AM–4:00 PM

68 SUNDAY PHYSIOLOGY

209. INTERMITTENT HYPOXIA: RESPIRATORY AND 4:15 The Other Orai Channels in Smooth Muscle Function. CARDIOVASCULAR CONTROL AND BEYOND M. Trebak. Albany Medical Col. 4:45 Gating Orai1/STIM1 by PIP2 Microdomains and Featured Topic Pancreatic Function. S. Muallem. NIDCR, NIH. (Sponsored by: APS Respiration Section) 212. SEX DISPARITIES IN CARDIOVASCULAR Sun. 3:15 pm—San Diego Convention Center, Room 25C FUNCTION AND REMODELING

Chaired: I.C. Solomon and D. Fields Featured Topic 3:15 Intermittent Hypoxia: A Low Risk Research Tool with (Sponsored by: APS Cardiovascular Section and AJP: Therapeutic Value in Humans. J. Mateika. Wayne Heart and Circulatory Physiology) State Univ. S 3:45 Modulation of Lower Urinary Tract (LUT) Function by Sun. 3:15 pm—San Diego Convention Center, Room 28B U Acute Intermittent Hypoxia. W. Collins III. Stony Chaired: S. Goulopoulou Brook Univ. N 4:15 Hypoxia Hits below the Diaphragm: Effect of Acute Sex Differences Hypoxia on the Micturition Reflex. M. Catege, I.C. Solomon, W.F. Collins. Stony Brook Univ. (986.1) 3:15 Sex-Based Differences in Non-Genomic Vascular 4:30 Pretreatment with Ampakine CX717 Enhances Long- Signaling. M. Hamblin. Tulane Univ. Term Facilitation of Inspiratory Hypoglossal (XII) 3:45 Inflammation and Extracellular Matrix Differences Bursting, but Only When Initial Burst Output Is Low. in Male and Female Aging in Mice. Y. Ma. Univ. of S. Turner, M. Elmallah, A. Hoyt, J. Greer, D. Fuller. Mississippi Med. Ctr. Univ. of Florida and Univ. of Alberta. (986.3) 4:15 Gender Differences in Cardiomyocyte Adhesion Cause 4:45 Antioxidant and Angiotensin AT1 Receptor Antagonist Heart Failure. G.L. Brower, Y. Du, E. Plante, J.A. Treatment Reduced the Hypertension Induced by Stewart; Jr., J.S. Janicki. Texas Tech Univ. Hlth. Sci. Chronic Intermittent Hypoxia in Rats, but Had Different Ctr., Univ. of South Carolina, Univ. of Montreal and Effects on Endothelial Dysfunction. R. Iturriaga, B. Mississippi State Univ. (738.11) Krause, P. Casanello, A.C.R. Dias, P. Arias, R. Del 4:30 Obesity-Associated Impairments in Autonomic Control Rio. Pontifical Catholic Univ. of Chile.(986.4) of Blood Pressure and Heart Rate Are Sex-Specific. 5:00 Chronic Intermittent Hypoxia Altered Stability of Rhythm T. Bruder-Nascimento, O.J. Ekeledo, R. Anderson, Generation but Increased Robustness of Respiratory H.B. Le, E.J. Belin de Chantemele. Med. Col. of Network. T. Dashevskiy, A.J. Garcia III, J-M. Georgia at Augusta Univ. (738.5) Ramirez. Seattle Children’s Res. Inst. and Univ. of 4:45 Sex-Specific Transcriptomic Regulation in the Diseased Washington. (986.5) Human Heart. G. Kararigas, H. Summer, I. Baczko, S. Golz, V. Regitz-Zagrosek. Charité Univ. Hosp., Berlin, Hlth.Care, Wuppertal, Germany and 210. MICROCIRCULATORY SOCIETY LANDIS Univ. of Szeged, Hungary. (738.9) AWARD LECTURE 5:00 Hypertension and Type II Diabetes Are Not Associated with Visceral Inflammation or Vascular Remodeling/ Lecture fibrosis in Obese Women. R. Fernandes, G.D. Fink, (Sponsored by: The Microcirculatory Society) J.J. Galligan, S.W. Watts, C. Pereira-Hicks, R.E. Watson, H. Xu. Michigan State Univ. (738.6) Sun. 3:15 pm—San Diego Convention Center, Room 23 How does Blood Flow Know Where to Go? S. Segal. 213. THE BRAIN-GUT AXIS: MICROBIOME IN Univ. of Missouri, Columbia. NEURAL AND METABOLIC DISEASES

211. ORAI/STIM1 PHYSIOLOGY Symposium AND PATHOPHYSIOLOGY (Sponsored by: APS Neural Control and Autonomic Regulation Section) Symposium Sun. 3:15 pm—San Diego Convention Center, Room 26 (Sponsored by: APS Cell and Molecular Physiology Section) Chaired: J. Zubcevic and M.K. Raizada

Sun. 3:15 pm—San Diego Convention Center, Room 25A Neurobiology

Chaired: S. Muallem and E. Delpire Hypertension

Ion Transport Microbiome Myocardial Infarction/Heart Failure 3:15 The Microbiota-Gut-Brain Axis in Health and Disease. J. Cryan. University Col. Cork, Ireland. 3:15 Orai/STIM1 Function and Cancer. N. Prevarskaya. 3:45 The Gut Microbiota and the Vagal Afferent Pathway - From Univ. of Sci. and Tech. of Lille, France. Bugs to Brain. H. Raybould. Univ. of California Davis. 3:45 Orai/STIM1 Function in the Immune System. S. Feske. 4:15 Gut Microbiome Influences Blood Brain Barrier New York Univ. Sch. of Med. Permeability in Mice. S. Pettersson. Karolinska Inst.

69 PHYSIOLOGY SUNDAY

4:45 Gut Dysbiosis is Linked to Hypertension. M. Santisteban. 216. ERNEST H. STARLING DISTINGUISHED Univ. of Florida. LECTURESHIP OF THE APS WATER AND ELECTROLYTE HOMEOSTASIS SECTION 214. WEH NEW INVESTIGATOR AWARD LECTURE Lecture Lecture Sun. 4:15 pm—San Diego Convention Center, Room 24 Sun. 3:15 pm—San Diego Convention Center, Room 24 Time to Re-think Sodium Homeostasis? D. Pollock. Blood Pressure and Fluid Volume Regulation in Pregnancy. Univ. of Alabama at Birmingham. E. George. Univ. of Mississippi. 216A. APS UNDERGRADUATE POSTER SESSION AND 215. WHAT DO BOTH MITOCHONDRIAL PROTEIN BRUCE AWARDS TURNOVER AND MITOCHONDRIAL FUNCTION Poster Discussion TELL US ABOUT EXERCISE AND AGING? Sun. 4:00 pm—San Diego Convention Center, Sails Pavilion Featured Topic (Sponsored by: APS Environmental and Exercise 217. MICROCIRCULATORY SOCIETY BUSINESS Physiology Section) MEETING AND RECEPTION Sun. 3:15 pm—San Diego Convention Center, Room 28A Business Meeting Chaired: B. Miller (Supported by Microcirculatory Society) Skeletal Muscle Physiology Sun. 4:30 pm—San Diego Convention Center, Room 23 Exercise, Aging, and Disease

3:15 What Does Mitochondrial Protein Turnover Tell Us 218. HENRY PICKERING BOWDITCH AWARD LECTURE about Exercise and Aging? K. Hamilton. Colorado State Univ. Lecture 3:45 What Does Mitochondrial Function Tell Us about Exercise and Aging? R. Boushel. Swedish Sch. of Sun. 5:45 pm—San Diego Convention Center, Sport and Hlth. Sci., Stockholm. Ballroom 20A 4:15 Effect of Partial Denervation Mitochondrial ROS Generation Sodium-Sensing Central to Salt-Sensitive Hypertension. in Skeletal Muscle. N. Pollock, C.A. Staunton, A. Vasilaki, S. Stocker. Penn State Col. of Med. A. McArdle, M. Jackson. Univ. of Liverpool. (764.1) 4:30 Exercise Training Induced Regulation of Muscle Mitochondrial Dynamics. D.K. Fix, J.P. Hardee, S. Gao, K.L. Hetzler, J.A. Carson. Univ. of South Carolina. (764.2) 4:45 Parkin-Mediated Mitophagy in Skeletal Muscle with Aging and Exercise. C. Chen, D. Hood. Sch. of Kinesiol. and Hlth. Sci., York Univ., Canada. (764.3) 5:00 Anabolic Response to Exercise Is Not Limited in Older Adults Despite Lower Mitochondrial Respiratory Capacity Compared to Young. I. Lanza, A. Lalia, S. Dasari, M. Robinson, H. Abid, D. Morse, K. Klaus. Mayo Clin. (764.4)

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70 MONDAY, APRIL 4 Across Societies

219. NIH K AWARDS Handouts and resource materials will be provided on-site. 9:00 Job Search in Academia & Industry. D. Behrens. Univ. Seminar of California, Berkeley. Mon. 9:00 am—San Diego Convention Center, 9:00 Building Your Skills, Networking & Information Interview. Exhibit Hall D A. Green. Univ. of California, Berkeley. 9:00 Goal Setting, Prioritizing, Time & Stress Management. NIH Grants Seminar H. Adams. H.G. Adams & Assocs. Inc., Norfolk, VA. Career Development 9:00 Responsible Conduct of Research Part 3: Best Practices: Publication Practices & Authorship, This presentation, by Dr. Henry Khachaturian of NIGMS, NIH, Conflicts of Interest, and Research. S. Sodeke, T. will focus on the NIH’s new K99/00 Pathways to Independence Turner. Tuskegee Univ., Jackson State Univ. M Award (for postdoctoral scientists) and the K08 Mentored Clinical 10:30 One Package: Your Resume, Interview and Job. Scientist Development Award (for individuals with a health J. Blumenthal. Montgomery Col., MD. O professional doctoral degree committed to a career in laboratory 10:30 How to Choose Your Ideal Career. B. Lindstaedt. UCSF. N or field-based research). The interactive discussion will give 10:30 Selling Yourself to the Life Sciences Industry. J. Tringali. attendees an opportunity to ask questions of and obtain insight Tringali & Assocs. Inc. from an NIH representative. 11:00 Developing Your Core Message/ “Elevator Pitch”. J. Lombardo. Med. Col. of Wisconsin and 220. NIH FELLOWSHIP (F) AWARDS Marquette Univ. 1:00 Translating Your Credentials on Paper (CV=>Resume) & In Person. A. Green. Univ. of California, Berkeley. Seminar 1:00 Job Hunting in Biotech Part 1: Finding & Applying for Mon. 1:00 pm—San Diego Convention Center, Exhibit Scientist Positions. B. Lindstaedt. UCSF. Hall D 1:00 Successful Behaviors for Winning an Interview. J. Blumenthal. Montgomery Col., MD. NIH Grants Seminar 1:00 Responsible Conduct of Research Part 1: Historical Career Development Perspectives: Past Controversies, Successes, and Present Challenges. S. Sodeke, T. Turner. Tuskegee This presentation, by Dr. Henry Khachaturian of NIGMS, Univ., Jackson State Univ. NIH, will focus on the NIH’s Ruth L. Kirschstein National Research 2:15 Beyond the Bench: Preparing for Your Career Transition Service Awards (NRSA). The NRSA research training fellowship in the Life Sciences. J. Tringali. Tringali & Assocs. Inc. (F) awards are targeted to individuals with or seeking research 2:30 Handshakes, Eye Contact, Small Talk: How to doctoral degrees (Ph.D. and equivalent) and clinical doctoral Successfully Network at a Conference. N. Saul. UCSF. degrees (M.D. and equivalent). Among the F awards discussed 2:30 Job Hunting in Biotech Part 2: Interviewing for Scientist will be the F30, NRSA Individual Predoctoral MD/PhD or Other Positions. B. Lindstaedt. UCSF. Dual-Doctoral Degree Fellowship Award, the F31 NRSA Individual 3:30 The Strategic Postdoc: How to Find & Leverage Predoctoral Fellowship, the F31 NRSA Individual Predoctoral Your Postdoc Experience. A. Green. Univ. of Fellowship to Promote Diversity in HealthRelated Research California, Berkeley. Award, the F32 NRSA Individual Postdoctoral Fellowship Award, 3:30 Overcoming Communication Barriers in the Grad and the NRSA Individual Senior Fellowship Award. The interactive Research Lab. H. Adams. H.G. Adams & Assocs. discussion will give attendees an opportunity to ask questions Inc., Norfolk, VA. of and obtain insight from an NIH representative on these and 4:00 Transforming Your CV/Cover Letter for Industry other awards available for pre- and postdoctoral fellows and Positions. N. Saul. UCSF. senior investigators. 4:00 Attitudes and Behaviors: How are you Perceived? J. Blumenthal. Montgomery Col., MD.

71 ANATOMY MONDAY Anatomy

222. MECHANOTRANSDUCTION IN DISEASE 224. MECHANICS OF THE CARDIOVASCULAR SYSTEM

Minisymposium Minisymposium (In collaboration with The Biomedical Engineering Society) (In collaboration with The Biomedical Engineering Society)

Mon. 8:30 am—San Diego Convention Center, Room 9 Mon. 10:30 am—San Diego Convention Center, Room 9

Cochaired: S. Simon and G. Schmid-Schoenbein Chaired: S. Li

Tissue Bioengineering Tissue Bioengineering Stem Cells/ Regeneration Cardiovascular Biology This session is part of the Tissue Mechanics & Morphogenesis Regenerative Medicine (Stem Cells, Tissue Mini-Meeting Regeneration, Biomaterials) 8:30 222.1 The Epigenomic Code in Hemodynamic This session is part of the Tissue Mechanics & Morphogenesis Regulation of Cell Phenotypes in Atherosusceptible Mini-Meeting Endothelium. P.F. Davies. Univ. of Pennsylvania. 10:30 224.1 Systems Mechanobiology and Multi- 9:00 222.2 Dysfunctional Mechanosensing of Extracellular scale Modeling of Ventricular Hypertrophy and Failure. Matrix in Thoracic Aortic Disease. J.D. Humphrey. Yale Univ. A.D. McCulloch, K. Buchholz, P. Tan, S. Dewan, J. Saucerman, 9:30 222.3 Mechanical Signaling in Epithelial- J.H. Omens, V. Nigam. UCSD and Univ. of Virginia. Mesenchymal Transition. A. Engler, J. Yang, M. Ondeck, 11:00 224.2 Cardiac Mechanics, Hemodynamics, and S. Wei. UCSD. Embryonic Heart Development. S. Rugonyi. Oregon Hlth. & Sci. Univ. 223. THE FATE OF THE CHONDROCYTE 11:30 224.3 Integrating Light-Sheet and Hemodynamic IN DEVELOPMENT, REGENERATION, Forces to Elucidate Cardiac Development, Injury and Repair. AND DISEASE T. Hsiai. UCLA.

Symposium 225. ANATOMY EDUCATION PLATFORM 1 Mon. 10:30 am—San Diego Convention Center, Room 10 Platform Chaired: R. Marcucio Mon. 10:30 am—San Diego Convention Center, Room 8 Developmental Biology/Morphology Cochaired: M. Hortsch and C. Krebs Stem Cells/ Regeneration Education and Teaching Regenerative Medicine (Stem Cells, Tissue Regeneration, Biomaterials) Adapting the Anatomical Sciences to Changing Curricula: Ideas, Tools and Validation 10:30 223.1 Transdifferentiation of Chondrocytes to Osteoblasts during Bone Fracture Healing. R. Marcucio, D. 10:30 225.1 The Effectiveness of Self-Paced Activities for Hu, F. Yang, C. Bahney, T. Miclau. UCSF and Orthopaed. Anatomy Instruction in a Case-Based Medical Curriculum. Trauma Inst., San Francisco. B. Szymik, D.W. Hesse. GRU/UGA Med. Partnership. 11:00 223.2 Genetic Control of Hypertrophic Chondrocyte 10:45 225.2 No Longer a Novelty: Formalizing Ultrasound- to Osteoblast Differentiation in Development and Skeletal Based Activities in Gross Anatomy through Objective Structural Disorders. K. Cheah, T. Au, S. Wynn, T. Tan, R. Yip, D. Chan. Practical Examination. T.R. Blankers, N. Lachman, A. Bhagra, Sch. of Biomed. Sci., The Univ. of Hong Kong and Univ. W. Pawlina. Mayo Med. Sch. and Mayo Clin. Col. of Med. of Melbourne. 11:00 225.3 X-perience – an Interactive Viewing Platform 11:30 223.3 Direct Transformation of Chondrocytes into Displaying Radiographic Profiles of Cadavers for Educational Bone Cells: Outside of the Box. J. Feng. Texas A&M Univ. Purposes. E. Nic an Riogh, G.F. Perry, J.F..X. Jones, Baylor Col. of Dent. A. Tattersall, M. Heduan, R.H. Stern, P. MacMahon, N. Giannotti, M. Davis. University Col. Dublin Sch. of Med., Mount Sinai Hosp., NY and Mater Misericordiae Univ. Hosp., Dublin. (568.23) 11:15 225.4 Microscopic Anatomy and Pathology Laboratories: Design of an e-Learning Atlas as an Evolving Response to Interdisciplinary Medical Curricular Needs. R.A. Jurjus, J. Wade, V. Moktan, M.S. Davis, A. Mills, G. Butera, J. Krum, P. Latham. George Washington Univ. Sch. of Med. 11:30 225.5 Emphasizing the Importance of Qualitative Research in Anatomy Education: A “How-to-Guide” on Case Study Design, Implementation, and Data Analysis. C.J. Traser. Indiana Univ. Sch. of Med.

72 MONDAY ANATOMY

11:45 225.6 Divide and Conquer: On Demand Anatomy in 3:20 227.5 Phantageusia: The Presence of Taste the Medical School Curriculum. M. Rosenberg, R. Hartley. Distortions Inhibited by Repetitive Transcranial Magnetic Univ. of New Mexico Sch. of Med. Stimulation. R.I. Henkin, M. Abdelmeguid, A.B. Knoppel, S.J. Potolicchio. The Taste and Smell Clin., Washington, DC and 226. CELL BIOLOGY AWARD HYBRID George Washington Univ. Med. Ctr.

Hybrid Symposium 228. MOLECULAR MECHANISMS OF TISSUE DYNAMICS Mon. 10:30 am—San Diego Convention Center, Room 7B

Chaired: A. Lysakowski Minisymposium

Cell Biology Mon. 2:00 pm—San Diego Convention Center, Room 9

R.R. Bensley Award Lecture in Cell Biology featuring 2016 Chaired: J.A. Guttman Young Investigator Award Recipient, Andrew Holland. Dan Tissue Bioengineering Georgess is competing as a finalist in the Postdoctoral Platform Presentation Award and Sahithi Pamarthy is competing as a Regenerative Medicine (Stem Cells, Tissue finalist in the Langman Graduate Platform Presentation Award Regeneration, Biomaterials) M 10:30 226.1 Deciphering How Cells Count: Molecular This session is part of the Tissue Mechanics & Morphogenesis O Control of Centrosome Copy Number. A. Holland, T. Moyer, Mini-Meeting N B. Lambrus, M. Levine, K. Clutario, P. Scott, V. Daggubati. Johns Hopkins Univ. Sch. of Med. 2:00 228.1 Molecular Asymmetries in Actin Dynamics 11:00 226.2 The Nature of Nurture: Investigating the Drive Left-Right Organogenesis. L.A. Trinh, E. Koo, V. Trivedi, Role of Notch Signaling and Vacuolar ATPase in Mammary M. Bagnat, S.E. Fraser. Univ. of So. California, Caltech and Gland Development. S. Pamarthy, L. Mao, G.K. Katara, M.K. Duke Univ. Jaiswal, A. Kulshrestha, A. Gilman-Sachs, K.D. Beaman. 2:30 228.2 Molecular Engineering for Imaging and Rosalind Franklin Univ. of Med. and Sci. Reprogramming in Live Cells. P.Y. Wang, J. Sun, L. Lei. UCSD 11:15 226.3 Twist1 Triggers PKD1 Expression to Promote and Univ. of Illinois at Urbana-Champaign. Metastatic Dissemination in Breast Cancer. D. Georgess, 3:00 Three-Dimensional Quantitative Delineation O.K. Sirka, N.M. Neumann, E.R. Shamir, A.J. Ewald. Johns of Spatially Heterogeneous Metastasis Landscape. S. Zhang. Hopkins Univ. Sch. of Med. Univ. of Notre Dame. 11:30 226.4 Cyclophilin A Is Crucial for Listeria and Salmonella Invasion and Cell-to-Cell Spreading. A. Dhanda, 229. EDUCATIONAL RESEARCH STUDENT K. Warren, J. Guttman. Simon Fraser Univ., Canada. PLATFORM AWARDS SESSION 11:45 226.5 Initiation of Smell in Congenital Smell Loss. R.I. Henkin, M. Abdelmeguid, A.B. Knoppel. The Taste and Award Competition Smell Clin., Washington, DC. Mon. 2:00 pm—San Diego Convention Center, Room 8

227. CLINICAL APPROACH IN MORPHOLOGICAL Chaired: J. Mussell RESEARCH Education and Teaching Hybrid Symposium Student and Postdoc award finalists present oral presentations to compete for the Education Platform Award (Cosponsored by: Brazilian Society of Anatomy) 2:00 Examination of the Roles of Learning Style and Learning Mon. 2:00 pm—San Diego Convention Center, Room 10 Strategy on the Academic Performance of First Year Chaired: V.P.S. Fazan Medical Students. C.T. Nichols, A.C. Edmondson. Med. Col. of Georgia at Augusta Univ. (569.5) Neurobiology 2:15 The Influence of Spatial Ability on Medical Student Developmental Biology/Morphology Performance in the Basic Sciences. A. Willis, A. Edmondson, C. Martin. Med. Col. of Georgia at 2:00 227.1 Experimental Evidence of a Hypertensive Augusta Univ., Augusta Univ. and Univ. of Western Neuropathy: Is It a New Disease?. V.S. Fazan. Univ. of São Paulo. Ontario. (570.5) 2:40 227.2 Aortic Depressor Nerve Morphology in Developing 2:30 Preliminary Results of a National Survey on the Spontaneously Hypertenvie Rats. M.M. Amorim, J.A. Castania, Integration of Anatomical Variations in Medical School H.C. Salgado, V.P.S. Fazan. Sch. of Med. of Ribeirão Preto, Brazil Curricula. C. Goldberg, D. Royer. Univ. of Colorado 2:50 227.3 Transcutaneous Vagus and Trigeminal Nerve Anschutz Med. Campus. (369.6) Stimulation for Neuropsychiatric Disorders: Underscoring 2:45 Problem Sets Allow for Multiple Competency Acquisition Anatomical Landmarks and Connections. M.D. Barros, A. in First Year Neuroscience Course. M.D. Lameka, Trevizol, I. Sato, B.M. Liquidato, Q. Cordeiro, P. Shiozawa. W.G. Pearson, A.C. Edmondson. Med. Col. of Santa Casa de São Paulo Sch. of Med. Sci. Georgia at Augusta Univ. (569.13) 3:10 227.4 Fos-Immunoreactive Neurons in Rat Intrinsic Cardiac Ganglia after Pericardial Capsaicin Injection. T. Wang, K.E. Miller. Oklahoma State Univ. Ctr. for Hlth. Sci.

73 ANATOMY MONDAY

3:00 Gross Anatomy Dissection Improves Exam Scores 5:15 231.5 Onset and Progression of Facet Joint Articular Amongst Medical and Allied Health Students. Cartilage Degeneration following Lumbar Spinal Hypomobility. R.J. Anders, A.C. Edmondson, C.M. Martin, K. J.A. Merlo, C. Lawson, J.A. McDowell, A.N. Benckendorf, Wheeler. Med. Col. of Georgia - Augusta Univ. and G.D. Cramer, J.W. Little. Saint Louis Univ. Sch. of Med. and Western Univ., Canada. (567.8) Doisy Col. of Hlth. Sci. and Natl. Univ. of Hlth. Sci., IL. 3:15 A Cadaveric Procedural Anatomy Course Enhances Operative Competence. G. Sharma, M.A. Aycart, T. van 232. TISSUE CONTRACTILITY AND MORPHOGENESIS Houten, D.S. Smink, R. Askari, J.D. Gates. Brigham and Women’s Hosp., Harvard Med. Sch. (567.7) Minisymposium

230. THE WIDE WORLD OF CORONARY ANOMALIES: Mon. 4:00 pm—San Diego Convention Center, Room 9 INSIGHT FROM THE CLINIC AND THE LABORATORY Chaired: A. Czirok

Symposium Tissue Bioengineering Stem Cells/ Regeneration Mon. 2:00 pm—San Diego Convention Center, Room 7B This session is part of the Tissue Mechanics & Morphogenesis Chaired: M. Watanabe Mini-Meeting Cardiovascular Biology 4:00 232.1 Self-Organizing Actomyosin Patterns on the Cell Biology Cell Cortex at Epithelial Cell-Cell Junctions. Z. Neufeld. Univ. of Queensland, Australia. 2:00 Chair’s Introduction. 4:30 232.2 Let There Be Force: Modeling Cell-ECM 2:05 230.1 Non-invasive Evaluation of Anomalous Aortic Interactions during Cancer Invasion. Y. Jiang. Georgia Origin of Coronary Arteries and Surgical Management. State Univ. R. Ashwath, D. Prasad. Case Western Reserve Univ. 5:00 232.3 The Role of Cell Contractility in Epithelial 2:30 230.2 Newer Concepts in Coronary Artery Anomalies, Morphogenesis. C.M. Nelson, V.D. Varner. Princeton Univ. Based on Accurate In Vivo Imaging (IVUS). P.E. Angelini, C.E. Uribe. Texas Heart Inst., Houston. 3:00 230.3 CXCL12 and Vascular Maturation of the 233. MACROPHAGES: WHAT ARE WE “SEEING” AND Coronary System during Heart Development. S. Cavallero, WHAT ARE WE MISSING? H. Shen, C. Yi, R.K. Subramanyan, H. Sucov. Univ. of So. California Keck Sch. of Med. (554.5) Symposium

Mon. 4:00 pm—San Diego Convention Center, Room 7B 231. MORPHOLOGICAL SCIENCES AWARD HYBRID Chaired: B. Singh

Hybrid Symposium Cell Biology Mon. 4:00 pm—San Diego Convention Center, Room 10 4:00 233.1 A New Look at the Alveolar Macrophage. Chaired: R. Daneman J. Bhattacharya. Columbia Univ. Med. Ctr. 4:30 233.2 Imaging the Role of Macrophage in Infection Developmental Biology/Morphology and Sterile Injury in Liver. P. Kubes, Z. Zeng, C. Jenne. Univ. of Calgary, Canada Evolution/Anthropology 5:00 233.3 Intravital Microscopy Identifies Macrophages Morphological Sciences Award Lecture featuring 2016 Young As Effector Cells for Monoclonal Antibody Therapy of Cancer. Investigator Award Recipient, Casey Holliday. Colin Moore, M. van Egmond. VU Univ. Med. Ctr., Amsterdam. Gillian Corbo and John Merlo are competing as finalists in the Langman Graduate Platform Presentation Award 234. AAA MEMBERS MEETING 4:00 231.1 Exploring Cranial Functional Morphology and Evolution through the Jaws of Alligators. C.M. Holliday. Univ. Business Meeting of Missouri-Columbia. Mon. 5:30 pm—San Diego Convention Center, Room 8 4:30 231.2 Ontogenetic Cranial and Postcranial Regional Variation in Bone Strength: Comparisons in Two Archaeological All AAA Members are encouraged to attend (formerly called Populations. E.M. Garofalo, M.A. Holmes. Univ. of Arizona the AAA Business Meeting) Col. of Med. and Sch. of Med., Duke Univ. (779.18) 4:45 231.3 Functional Anatomy of the Palmaris Brevis: 235. GRADUATE STUDENT/POSTDOC Grasping for Answers. C.W. Moore, C.L. Rice. Sch. of Kinesiol. Aad Schulich Sch. of Med. and Dent., Univ. of Western Ontario. POSTER RECEPTION 5:00 231.4 The Anterolateral Ligament and the Lateral Meniscus’ Synergistic Contribution to Rotational Knee Stability. G.G. Poster Discussion Corbo, T. Lording, T. Burkhart, M. Johnson, A. Getgood. Western Mon. 6:00 pm—San Diego Convention Center, Univ., Canada and Melbourne Orthopaed. Gp., Windsor, Australia. West Terrace Lobby

74 MONDAY BIOCHEMISTRY Biochemistry and Molecular Biology

236. ASBMB PLENARY LECTURE 10:30 239.2 Dissecting the Role of the Rad51 Paralogs during Double-Strand Break Repair. K. Bernstein, T.B. Award Lecture McClendon, M.R. Sullivan, S.K. Godin, W. Gaines, P. Sung, J. Yanowitz. Univ. of Pittsburgh Sch. of Med. and Yale Univ. Mon. 8:00 am—San Diego Convention Center, Room 6B 10:55 Estrogen Induces RAD51C Expression and 8:00 Awardee introduction. Localization to Sites of DNA Damage. M.K. Holz. Yeshiva 8:05 236.1 Illuminating Biology at the Nanoscale with Univ., NY. (799.1) Single-Molecule and Super-Resolution Imaging. X. Zhuang. 11:10 Interactomic and Enzymatic Analyses of Harvard Univ., HHMI. Distinct Affinity Isolated Human Retrotransposon Intermediates. J. LaCava, K.R. Molloy, D. Fenyö, M.S. Taylor, B.T. Chait, J.D. 237. ASBMB PLENARY LECTURE Boeke, M.P. Rout. The Rockefeller Univ.,NYU Sch. of Med. and Massachusetts Gen. Hosp. (801.1) Plenary 11:25 239.3 The Role of Mammalian Polymerase Theta in DNA Repair. A. Sfeir. NYU Sch. of Med. Mon. 8:45 am—San Diego Convention Center, Room 6B 11:50 Discussion. M O 8:45 Awardee introduction. 8:50 237.1 Functionalizing the Unannotated Mitochondrial 240. ENZYME DYNAMICS AND ENZYME MOTIONS N Proteome. J.P. Rutter. HHMI, Univ. of Utah. Symposium

238. ALICE AND C.C. WANG AWARD IN MOLECULAR Mon. 9:45 am—San Diego Convention Center, Room 6C PARASITOLOGY SYMPOSIUM Follow the conversation: #catalysis Award Lecture 9:45 Chair’s Introduction. 9:50 240.1 Observations on the Cellular Dynamics of Mon. 9:45 am—San Diego Convention Center, Room 1A a Metabolic Complex, the Purinosome. S. Benkovic, C.Y. 9:45 Awardee introduction. Chan, D. Kim, A. Pedley, X. Zhuang. Penn State and Harvard/ 9:50 238.1 Translating the Trypanosome Surface. HHMI, Cambridge. M.A.J. Ferguson, M.L.S. Güther. Sch. of Life Sci., Univ. of 10:15 Large Scale Structural Rearrangement Dundee, U.K. Provides Dual Control Over the Catalytic and Membrane 10:30 238.2 Tracking the In Vivo Dynamics of Antigenic Binding Activity of a Bacterial Serine Hydrolase. R.J. Johnson, Variation in Trypanosoma brucei. M. Mugnier, G.A.M. Cross, M. Smith, W. Hart. Butler Univ. (833.6) F.N. Papavasiliou. The Rockefeller Univ. 10:30 240.2 NMR Relaxation Dispersion. P. Loria. 11:00 238.3 Carbon Metabolism of Parasitic Protozoa: Yale Univ. Strategies for Surviving in Intracellular Niches. M. McConville, 10:55 Conservative Substitutions of Buried Amino E. Saunders, F. Sernee, M. Blume, J. Kloehn, J. Ralton. Univ. Acid Residues Distant from the Active Site of Horse Liver of Melbourne. Alcohol Dehydrogenase Have Small Effects on Structure, 11:30 238.4 A Clinical Candidate Targeting Dihydroorotate Catalysis and Dynamics. B.V. Plapp, K. Shanmuganatham, Dehydrogenase for the Treatment of Malaria with Blood R.S. Wallace, A.T-I. Lee. Univ. of Iowa. (833.5) and Liver Stage Activity. M.A. Phillips, S.A. Charman, P.K. 11:10 Control of Enzyme Function through Loop Rathod, J. Burrows, T. Rueckle. Univ. of Texas Southwestern Dynamics. C.N. Chi, B. Vogeli, S. Bibow. ETH, Zurich. (835.2) Med. Ctr., Monash Inst. of Pharmaceut. Sci., Australia, Univ. of 11:25 240.3 Separated at Birth, the Evolution of Kinase Washington and Meds. for Malaria Venture, Geneva. Dynamics over a Few Billion Years. D. Kern. HHMI, Brandeis Univ. 239. REGULATION OF RECOMBINATION 11:50 Discussion.

Symposium 241. BUILDING MOLECULAR MACHINERY

Mon. 9:45 am—San Diego Convention Center, Room 1B Symposium Chaired: C. Kisker Mon. 9:45 am—San Diego Convention Center, Room 6D

Follow the conversation: #DNA Chaired: C.M. Dunham 9:45 Chair’s Introduction. Follow the conversation: #proteins 9:50 239.1 Regulation of Homologous Recombination: Robustness through Reversibility. W-D. Heyer. Univ. of 9:45 Chair’s Introduction. California, Davis. 9:50 241.1 Molecular Switches in Proteasome Assembly: 10:15 Live Cell Interrogation of dCas9:sgRNA Tales of the Tails and Chaperones. S. Park. Univ. of Dynamics off and at the Target. T. Pederson. Univ. of Colorado Boulder. Massachusetts Med. Sch. (571.1) 10:15 Functional Cooperativity between the Trigger Factor Chaperone and the ClpXP Degradation System. W.A. Houry. Univ. of Toronto. (811.6)

75 BIOCHEMISTRY MONDAY

10:30 241.2 Quality Control of Nuclear Pore Complex 10:30 243.2 Transcriptional Control of Lipid Homeostasis. Biogenesis. P. Lusk, B. Webster, J. Jaeger, D. Thaller. Yale P. Totonoz. UCLA. Sch. of Med. and Univ. of California Berkeley. 10:55 HPV16-E7 Oncoprotein Enhances Ceramide- 10:55 Illuminating the Proteasome: Fluorescence Mediated Lethal Mitophagy by Regulating the Rb/E2F5/Drp1 Assays for Investigating the Kinetics of Proteasome Substrate Signaling Axis. R. Thomas, N. Oleinik, B. Ogretmen. Med. Processing. J.A. Bard, E. Jonsson, A. Martin. Univ. of Univ. of South Carolina. (872.6) California, Berkeley. (597.2) 11:10 Cysteinyl Leukotriene 2 Receptor Enhances 11:10 Translocating Loop-Substrate Interactions Angiogenesis, Vascular Permeability and Tumor Metastasis. Mediate Subunit Coordination and Regulate the E. Duah, V. Kondeti, N. Al-Azzam, R. Adapala, P. Patil, C. Mechanochemical Coupling and Power Production in a AAA+ Thodeti, S. Paruchuri. Univ. of Akron and Northeast Ohio Protease Machine. P. Rodriguez, L. Ramirez, F. Kim, C. Med. Univ. (872.4) Bustamante, A. Martin. Univ. of California, Berkeley. (595.2) 11:25 243.3 The Phase of Fat: Mechanisms and Physiology 11:25 241.3 Quality Control in 40S Ribosome Maturation. of Lipid Synthesis and Storage. R.V. Farese, T. Walther. K. Karbstein. The Scripps Res. Inst. Harvard Univ., Boston. 11:50 Discussion. 11:50 Discussion.

242. MECHANISTICALLY-INFORMED DRUG DESIGN 244. BIOCHEMISTRY AND TODAY’S PRE- MED STUDENT Symposium Symposium Mon. 9:45 am—San Diego Convention Center, Room 6E (Sponsored by: ASBMB Education and Professional Chaired: J.W. Kozarich Development Committee) Follow the conversation: #metabolism Mon. 9:45 am—San Diego Convention Center, Room 14A 9:45 Chair’s Introduction. Chaired: E. Hodis 9:50 242.1 trans-Translation as a Target for Novel Antibiotics. K. Keiler. Penn State Follow the conversation: #education 10:15 Novel Small Molecule, WZB117, Competitively Inhibit GLUT1-Mediated Glucose Transport to Halt Cancer 9:45 Chair’s Introduction. Growth. O. Ojelabi, J. DeZutter, K. Lloyd, A. Carruthers. 9:50 244.1 MCAT2015: A New Focus on Biochemistry. Univ. of Massachusetts Med. Sch. (1099.1) S.H. Oyewole. Trinity Washington Univ., Alexandria, VA. 10:30 242.2 Identifying Vulnerable Steps in the Coenzyme A 10:15 Creating an Outcomes-Based Biochemistry Biosynthesis Pathway of M. tuberculosis. V. Mizrahi, J. Evans, Major from ASBMB and ACS Major Guidelines That Reflects C. Trujillo, H. Eoh, S. Ehrt, D. Schnappinger, H. Boshoff, K. MCAT Needs. J.K. Bell, T.J. Dwyer, C.M. Loer, M.S. Lowery, Rhee, C.E. Barry III. Univ. of Cape Town, Weill Cornell Med. J.J. Provost. Univ. of San Diego. (887.2) Col. and NIAID, NIH. 10:30 244.2 Transformation in Biomedical Science 10:55 Differential Regulation of mTORC1 by Amino Education for Future Physicians. S. Lieberman. Univ. of Texas Acids. J.L. Jewell, K-L. Guan. Univ. of Texas Southwestern Med. Br. Sch. of Med. Med. Ctr. and UCSD. (1099.18) 10:55 Organic Chemistry and Biochemistry 11:10 Potent Lipidated Antagonists to Protease- Curriculum for the New MCAT. Y. Dobrydneva, L. Schwartz. Activated Receptor 2. S. Boitano, J. Hoffman, A. Flynn, C.L. George Washington Sch. of Med. and Hlth. Sci. (887.1) Sherwood, Z. Zhang, R. Patek, T.J. Price, J. Vagner. Univ. of 11:10 Integration of Biochemistry and Problem Arizona and Univ. of Texas at Dallas, Richardson. (848.6) Solving-Based Pedagogy throughout the Chemistry 11:25 242.4 Rational Optimization of Natural-Born Curriculum in Support of Learning Outcomes Articulated by the Mechanism-Based Inhibitors of the 20S Proteasomes in Association. of American Medical Colleges., the ASBMB and Humans and Mycobacterium tuberculosis. J. Sello. Brown Univ. the American Chem. Soc. H.V. Jakubowski, K. Graham, E. 11:50 Discussion. McIntee, C. Schaller. Col. St. Benedict/St. John’s Univ., MN. (662.12) 11:25 244.3 A Description of the First Year of the New 243. LIPID SIGNALING MCAT® Exam. M. Kroopnick. Assn. of American Med. Cols., Washington, DC. Symposium 11:50 Discussion. Mon. 9:45 am—San Diego Convention Center, Room 6F 245. ASBMB ACCREDITATION WORKSHOP Chaired: G.M. Carman

Follow the conversation: #lipids Workshop

9:45 Chair’s Introduction. Mon. 12:15 pm—San Diego Convention Center, Room 14A 9:50 243.1 Sphingosine-1-Phosphate: A Bridge from Learn the characteristics of an ASBMB-accredited Bench to Clinic. S. Spiegel. VCU Sch. of Med. undergraduate program. 10:15 Tracking Diacylglycerol Pools in Budding Yeast. S. Ganesan, M.L. Sosa Ponce, V. Zaremberg. Univ. of Calgary, Canada. (872.3)

76 MONDAY BIOCHEMISTRY

246. TELL YOUR SCIENCE AS A STORY 3:20 250.1 Symmetry and Computational Methods in the Design of Self-Assembling Protein Materials. Special Session T.O. Yeates. UCLA. (Sponsored by: ASBMB Public Outreach Committee) 251. ENZYMOLOGY OF GLYCOSYL-TRANSFERASES Mon. 12:30 pm—San Diego Convention Center, Room 6A AND HYDROLASES

Symposium 247. MILDRED COHN AWARD IN BIOLOGICAL CHEMISTRY AWARD LECTURE Mon. 4:00 pm—San Diego Convention Center, Room 1A

Chaired: D. Vocadlo Award Lecture Follow the conversation: #glyco Mon. 2:15 pm—San Diego Convention Center, Room 6B 4:00 Chair’s Introduction. 2:15 Awardee introduction. 4:05 251.1 Insights on Mammalian Glycosylation Enzymes 2:20 247.1 Molecular Visualization of the Eukaryotic from High-Throughput Expression Studies. K. Moremen, L. Transcription Initiation Process Using Cryo-EM. E. Nogales, R. Meng, F. Forouhar, S. Wang, R. Kadirvelraj, H. Moniz, A. Louder, Y. He. Univ. of California, Berkeley, HHMI, Lawrence M Ramiah, Z. Gao, J. Seetharaman, S. Milaninia, G. Galay, M. Berkeley Natl. Lab. and Northwestern Univ. O Stuart, J. Steel, J. Labaer, Z. Wood, L. Tong, D. Jarvis. Univ. of Georgia, Columbia Univ., Univ. of Wyoming and Arizona N 248. EARL AND THRESSA STADTMAN SCHOLAR State Univ. AWARD LECTURE II 4:30 Regulation of Notch Signaling by O-Glucosylation: Notch-Modifying Xylosyltransferase- Award Lecture Substrate Complexes Support an SNi-Like Retaining Mechanism. R.S. Haltiwanger, H. Yu, M. Takeuchi, J. Mon. 2:50 pm—San Diego Convention Center, Room 6B LeBarron, J. Kantharia, E. London, H. Bakker, H. Li, H. 2:50 Awardee introduction. Takeuchi. Univ. of Georgia, Brookhaven Natl. Lab., NY, Stony 2:55 248.1 Molecular Choreography of an Antibiotic Brook Univ. and Hannover Med. Sch., Germany. (624.3) Assembly Line. S. Dutta, J.R. Whicher, D.A. Hansen, W.A. 4:45 251.2 Mechanistic and Structural Insights into a Hale, J.A. Chemler, G.R. Congdon, A.R. Narayan, K. Human Carbohydrate Degrading Enzyme. T. Gloster, M. Håkansson, D.H. Sherman, J.L. Smith, G. Skiniotis. Univ. Alteen, V. Oehler, L. Yang, I. Wilson, D. Vocadlo. Univ. of of Michigan. St. Andrews, U.K., Simon Fraser Univ., Canada and Univ. of Natural Resources and Life Scis., Vienna, Austria. 249. SICKLE CELL DISEASE SEVERITY 5:10 Structure and Biosynthesis of Complex N-Glycan Cores and Antennae in Nematodes. I.B.H. Wilson, Symposium S. Yan, K. Paschinger. Univ. of Nat. Resources and Life Sci., Vienna. (843.4) (Guest Society: Society for Experimental Biology and 5:25 Defects in Protein O-Mannosylation Result in Medicine) Abnormal Muscle Contractions and Aberrant Neural Sensory Mon. 3:00 pm—San Diego Convention Center, Room 6A Feedback in Drosophila. V. Panin, R. Baker, N. Nakamura, D. Lyalin. Texas A&M Univ. (846.1) Cochaired: S.R. Goodman and B.S. Pace 5:40 251.5 Piecing Together New Insight into Clinical severity in sickle cell disease: definitions and Glycosidases: Structure and Imaging. G. Davies. Univ. of York. prognostication C. Quinn. 6:05 Discussion.

Rheological Abnormalities of Pediatric Hemoglobin SC 252. TRANSCRIPTIONAL Patients V. Sheehan. REGULATORY MECHANISMS Genetic Basis of HbF Variability in Sickle Cell Anemia; A Global Perspective M. Steinberg. Symposium

Is Hydroxyurea Efficacious in Both Severe and Non-Severe Mon. 4:00 pm—San Diego Convention Center, Room 1B Sickle Cell Disease?” Clinical severity in sickle cell disease: Chaired: S. Lauberth definitions and prognosticationW. Wang. Follow the conversation: #chromatin 250. DELANO AWARD FOR COMPUTATIONAL 4:00 Chair’s Introduction. BIOSCIENCES LECTURE 4:05 252.1 Impeding the Formation of Transcription Initiation Complex. J-M. Egly. IGBMC, CNRS, INSERM, Univ. Award Lecture of Strasbourg, Illkirch. 4:30 Mechanistic Study of ERCC6/CSB Enzymatic Mon. 3:15 pm—San Diego Convention Center, Room 6B Regulation, and Its Roles in Transcription Elongation, and 3:15 Awardee introduction. Chromatin Remodeling. D. Wang. UCSD. (803.8)

77 BIOCHEMISTRY MONDAY

4:45 252.2 Transcription and the Maintenance of Genome 255. SYSTEMS BIOLOGY OF Stability. J.Q. Svejstrup, L. Williamson, M. Saponaro, CELLULAR NETWORKS S. Boeing, R. Mitter, G. Kelly. The Francis Crick Inst., South Mimms and London, U.K. Symposium 5:10 Receptors Can Activate Unique FoxA1 Binding Patterns through a Highly Dynamic Mechanism Mon. 4:00 am—San Diego Convention Center, Room 6D Associated with a Fast DNA Residence Time. E.E. Swinstead, Chaired: A. Osterman T.B. Miranda, V. Paakinaho, S. Baek, M. Hawkins, T. Karpova, D. Ball, D. Mazza, L.D. Lavis, T. Morisaki, L. Grøntved, D.M. Follow the conversation: #proteomics Presman, G.L. Hager. NCI, NIH, Univ. Vita Salute San Raffaele, 4:00 Chair’s Introduction. Milan, HHMI, Ashburn, VA and Univ. of So. Denmark. (585.5) 4:05 ASBMB Young Investigator Award Introduction 5:25 DNA Breaks and Damage Response Signaling and Presentation. Are Coupled with RNA Polymerase II Promoter-Proximal Pause 4:10 Adaptations to Mitochondrial Dysfunction via Release and Required for Effective Transcriptional Elongation. Inter-Organelle Communication. C.M. Haynes. Mem. Sloan H. Bunch. Harvard Med. Sch., Beth Israel Deaconess Med. Kettering Cancer Ctr. (254.1) Ctr. (589.1) 4:35 255.3 Integrative Pathway Mapping. A. Sali. UCSF. 5:40 252.3 Elongin and the Elongin A Ubiquitin Ligase 5:00 GRNmap and GRNsight: Open Source Complex in Transcription and the Response to DNA Damage. Software for Dynamical Systems Modeling and Visualization J.W. Conaway, J.C. Weems, B.D. Slaughter, J.R. Unruh, R.C. of Medium-Scale Gene Regulatory Networks. K.D. Dahlquist, Conaway. Stowers Inst. for Med. Res. and Univ. of Kansas B.G. Fitzpatrick, J.D.N. Dionisio, N.A. Anguiano, J.S. Med. Sch. Carrillo, M.V. Hong, K.M. Horstmann, K.C. Jackson, K.G. 6:05 Discussion. Johnson, T.A. Morris, T.A.M. Roque, M. Samdarshi, A. Varshneya, N.E. Williams, K.W. Wyllie. Loyola Marymount 253. THE GREENING OF CHEMICAL BIOLOGY Univ., CA and Spelman Col., GA. (819.16) 5:15 255.2 The Cancer Cell Map Initiative. T. Ideker. UCSD. Symposium 5:40 255.1 Network Analytics: Evolutionary Compression,

Mon. 4:00 pm—San Diego Convention Center, Room 6C Diffusion and the Action Equation for Mutations. O. Lichtarge. Baylor Col. of Med. Chaired: M. Burkart 6:05 Discussion. Follow the conversation: #chembio 256. SIGNALING IN TIME AND SPACE 4:00 Chair’s Introduction. 4:05 253.1 Chemical Biology and Endomembrane Symposium Trafficking in . G.R. Hicks, C. Zhang, W. Van de Ven, R. Li, N. Raikhel. Univ. of California, Riverside. Mon. 4:00 pm—San Diego Convention Center, Room 6E 4:30 Molecular and Expression of a Putative Chaired: D.J. Leahy Oleate Hydratase Isozyme from Nocardia cholesterolicum NRRL 5767. J-K. Huang, H.B. Alhmadi, D.R. Vanderway, C.A. Follow the conversation: #cellsignal Hoerner, L. Wen. Western Illinois Univ. (838.1) 4:00 Chair’s Introduction. 4:45 253.2 Alkaloid Biosynthesis in Plants. S. O’Connor. 4:05 256.1 Endocytosis Separates EGF Receptors from John Innes Ctr., Norwich, U.K. Endogenous Fluorescently Labeled HRas and Prevents 5:10 Digging into Rice Diterpenoid Biosynthesis. Receptor Signaling to MAP Kinases in Endosomes. A. Sorkin, R. Peters. Iowa State Univ. (1146.1) I. Pinilla-Macua. Univ. of Pittsburgh. 5:25 Structural Basis of Distinct Salicylic Acid 4:30 Super-Resolution Imaging of the HER Family Glucosylation in by Two Homologous of Receptor Tyrosine Kinases. B. van Lengerich, E. Puchner, Enzymes: Implications for Plant Stress Response. A.M. George B. Huang, N. Jura. UCSF and Univ. of Minnesota, Minneapolis. Thompson, C.V. Iancu, J. Dean, J-y. Choe. Rosalind Franklin (857.4) Univ. and DePaul Univ. (1142.3) 4:45 256.2 New Mode of EGF Receptor Transactivation: 5:40 253.3 Molecular Controls in Plant Hormone Signaling. Regulated Ligand Delivery. R.J. Coffey, Z. Cao, B. Singh. J. Jez. Washington Univ. in St. Louis. Vanderbilt Univ. Med. Ctr. and DVA Nashville, TN. 6:05 Discussion. 5:10 Three-Dimensional Quantification of the Spatiotemporal Co-evolution of Vascular and Neuronal 254. ASBMB YOUNG INVESTIGATOR AWARD LECTURE Networks within Intact Eyes. J. Singh, D. Shepherd, G. Seedorf, J. Brzezinski Univ. of Colorado Denver and Univ. Award Lecture of Colorado Sch. of Med., Aurora. (857.1)

Mon. 4:00 pm—San Diego Convention Center, Room 6D 5:25 An Optogenetic Toolkit for Spatial and Temporal Control of the cAMP Dependent Protein Kinase. Presented in session, “Systems Biology of Cellular C.P. OBanion, R. Hughes, M. Priestman, D. Lawrence. Univ. Networks”. Refer to session 255 for additional details. of North Carolina Chapel Hill. (857.2) 4:00 Awardee introduction. 5:40 256.3 Spatial Correlation of Constitutive HER2 4:00 254.1 Adaptations to Mitochondrial Dysfunction via Activities with Cell Membrane Deformation. I. Chung. HHMI, Inter-Organelle Communication. C.M. Haynes. Mem. Sloan Ashburn, VA and Genentech, South San Francisco. Kettering Cancer Ctr. 6:05 Discussion.

78 MONDAY BIOCHEMISTRY

257. NAFLD: GENETIC DETERMINANTS AND 4:30 Combining Molecular Visualization with Bench EXTRAHEPATIC COMPLICATIONS Methods in a Hypothesis-Driven Undergraduate Biochemistry Lab Course. P.A. Craig, J.L. Mills, C. Daubner, M.J. Pikaart. Symposium Sch. of Chem. & Mat. Sci., Rochester Inst. of Technol., Sch. of Sci., Engin. and Technol., St. Mary’s Univ., San Antonio and (Sponsored by: ASBMB Minority Affairs Committee) Hope Col., MI. (666.2) Mon. 4:00 pm—San Diego Convention Center, Room 6F 4:45 258.2 Visualizing the Invisible: From Questions to Conversations to Understanding. T. Herman. Milwaukee Sch. Chaired: T. Sumter of Engin. 5:10 Molecular Visualization in the Classroom: Follow the conversation: #liver Learning Goals and Competencies. D.R. Dries, P.A. Craig, 5:10 Dietary Docosahexaenoic Acid Halts Progression of D.M. Dean, L. Listenberger, W.R.P. Novak, M.A. Franzen. Nonalcoholic Steatohepatitis, but Does Not Promote Juniata Col., PA, Rochester Inst. of Technol., Univ. of Saint Fibrosis Remission in Ldlr-/- mice. K.A. Lytle, C. Joseph, CT, St. Olaf Col., MN, Wabash Col., IN and Milwaukee Wong, D. Jump. Oregon State Univ. (870.2) Sch. of Engin. (666.1) 4:45 Genetic and Environmental Risk Factors for Progression 5:25 Reviving “Byron’s Bender”: Hands-On of NASH R. Loomba, UCSD. Molecular Visual and Tactile Learning at the Most Basic Level. 5:25 Regulation of AMPK and Hepatic Metabolism by Folic J.T. Hazzard, A. Issaian. Univ. of Arizona and Univ. of Colorado M Acid Supplementation in Non-alcoholic Fatty Liver Anschutz Med. Campus. (666.6) O Disease. V. Sid, N. Wu, L. Sarna, Y. Shang, J. House, 5:40 258.3 Creating Stop-Motion Animations to Learn N Y.L. Siow, K. O. Univ. of Manitoba, St. Boniface Molecular Biology Dynamics. C. Peterson, P. Ngo. Suffolk Univ. Hosp. Res. Ctr. and Agr. and Agri-Food Canada, 6:05 Discussion. Winnipeg. (870.3) 4:30 Obesity Intensifies Hepatotoxicity by Asparaginase in 259. ORGANIZING A SUCCESSFUL ASBMB Mice Deleted for GCN2 but Not ATF4. I.A. Nikonorova, STUDENT CHAPTER E.T. Mirek, Y. Wang, J.L. Dixon, T.G. Anthony. Rutgers, The State Univ. of New Jersey. (1126.1) Special Session 5:40 257.1 The Early Origins of NAFLD in Humans and Non-human Primates. J.E. Friedman. Univ.of Colorado Denver. (Sponsored by: ASBMB Education and Professional 4:05 257.2 Mitochondrial Protonophores for Treatment of Development Committee) NAFLD/NASH and Type 2 Diabetes. G.I. Shulman. HHMI/Yale Mon. 6:15 pm—San Diego Convention Center, Room 14A Univ. Sch. of Med. 6:05 Discussion. 4:00 Chair’s Introduction. 260. ASBMB GAME NIGHT

258. MOLECULAR VISUALIZATION IS YOUR FRIEND Special Event

Mon. 6:30 pm—San Diego Convention Center, Room 6A Symposium Join the ASBMB for an evening of networking and science- (Sponsored by: ASBMB Education and Professional themed trivia with fellow graduate students and postdoc members Development Committee) and biochem attendees. Mon. 4:00 pm—San Diego Convention Center, Room 14A

Chaired: M.A. Carroll 261. ASBMB WIKI EDIT-A-THON Follow the conversation: #education Workshop 4:00 Chair’s Introduction. (Sponsored by: Simons Foundation) 4:05 258.1 Proteopedia: The 3D Wiki-Encyclopedia of Protein and Nucleic Acid Structures. E. Hodis, J. Prilusky, J. Mon. 6:30 pm—San Diego Convention Center, Room 14B Sussman. Harvard Univ., MIT, Broad Inst., Cambridge, MA, Come join ASBMB and the Simons Foundation at our Dana-Farber Cancer Inst. and Weizmann Inst. of Sci., Israel. Wikipedia Edit-A-Thon, where we will tackle molecular biology and biochemistry Wikipedia articles that are in dire need of renovation and teach you the basics of Wikipedia editing.

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79 NUTRITION MONDAY Nutrition

262. ASN SPONSORED SATELLITE PROGRAM: 266. REGULATION OF HEALTH AND DISEASE BY FOOD FOR THE BRAIN: LEARNING HOW WHAT SULFUR AMINO ACID METABOLISM WE EAT AFFECTS COGNITION AND MAY PREVENT OR DELAY DEMENTIA Symposium

Mon. 8:00 am—San Diego Convention Center, Room ASN Satellite 31ABC

(Organized and Sponsored by: the California Chaired: T.G. Anthony Walnut Commission) Cochaired: J.W. Miller Mon. 6:30 am—San Diego Convention Center, Room 33BC Cellular and Molecular Nutrition For more information on ASN Sponsored Satellite Programs, please visit http://scientificsessions.nutrition.org 8:00 H2S in Health and Disease. R. Banerjee. Univ. /satellitesessions/. of Michigan. 8:25 Endogenous Hydrogen Sulfide Production is Essential for Dietary Restriction Benefits. J. Mitchell. Harvard 263. ASN SPONSORED SATELLITE PROGRAM: T.H. Chan Sch. of Publ. Hlth. LOW CALORIE SWEETENER AND OBESITY: 8:50 Influence of Vitamin B6 Status on the In vivo Function SOLUTION OR PART OF THE PROBLEM of the Transsulfuration Pathway in Sulfur Amino Acid Metabolism and Hydrogen Sulfide Production. ASN Satellite J. Gregory. Univ. of Florida. (Organized and Supported by: Tate and Lyle) 9:15 Cysteine and Obesity: Does Cysteine Link Amino Acid and Lipid Metabolism? H. Refsum. Univ. of Oslo Inst. Mon. 6:30 am—San Diego Convention Center, Room 32AB of Basic Med. Sci.

267. ENERGY AND MACRONUTRIENT METABOLISM: 264. AGING AND CHRONIC DISEASE RIS LIPID AND FATTY ACID METABOLISM BUSINESS MEETING AND TRANSPORT RIS Forum Minisymposium (Sponsored by: Aging and Chronic Disease RIS) (Sponsored by: Energy & Macronutrient Metabolism RIS) Mon. 7:00 am—San Diego Convention Center, Room 28DE Mon. 8:00 am—San Diego Convention Center, Room 33A Chaired: C. Castaneda-Sceppa Chaired: M. Jacome-Sosa

Cochaired: J.M. Ellis 265. RED AND PROCESSED MEATS AND HEALTH: CONTROVERSIES FOR DIETARY GUIDANCE 8:00 267.1 Supplementation with Dietary EPA/DHA Influences Red Blood Cell Fatty Acid Desaturase Estimates Symposium and Reflects Tissue Changes in Fatty Acids in Systemic Organs. E.A. Davidson, C.A. Pickens, J. Fenton. Michigan Mon. 8:00 am—San Diego Convention Center, State Univ. Ballroom 20D 8:15 267.2 Lipid Emulsions, Rich in n-3 or n-9 Fatty Acids, Chaired: W.W. Campbell Reverse the Progression of Parenteral Nutrition-Induced Hepatic Steatosis in Mice. K-H. Huang, P.B. Smith, A.D. Cochaired: F.B. Hu Patterson, A.C. Ross. Penn State 8:30 267.3 Effects of Hormone Therapy on the Association Clinical and Translational Nutrition between Erythrocyte Levels of n-3 Polyunsaturated Fatty Acids 8:00 Red and Processed Meats in the American Diet: and Depression in Postmenopausal Women. Y. Jin, Y. Park. How Much Do We Really Eat? K. Belk. Colorado Hanyang Univ., South Korea. State Univ. 8:45 267.4 A 22 bp FADS2 Insertion-Deletion 8:20 Red Meat Intake and Dietary Patterns for Cardio- Polymorphism Influences Arachidonic Acid Status. K.S.D. metabolic Health. F. Hu. Harvard Univ. Kothapalli, M.S. Gadgil, S.E. Carlson, K.O. O’Brien, K. Ye, 8:55 Red Meat Intake and Dietary Patterns for J.Y. Zhang, H.G. Park, K. Ojukwu, J. Zou, S.S. Hyon, K.S. Cancer Prevention. M. McCullough. American Joshi, A. Keinan, J.T. Brenna. Cornell Univ., Univ. of Pune, Cancer Society. India and Univ. of Kansas. 9:30 Dietary Guidance and the Future of Red Meats. 9:00 267.5 Dietary α-Linolenic Acid-Rich Flax Oil Elevates W. Campbell. Purdue Univ. Renal and Hepatic Docsosahexaenoic Acid-Derived Bioactive Lipids. J.G. Devassy, T. Yamaguchi, N. Ibrahim, M. Gabbs, T. Winter, A. Ravandi, H.M. Aukema. Univ. of Manitoba and St. Boniface Hosp. Res. Ctr., Winnipeg.

80 MONDAY NUTRITION

9:15 267.6 Programming Effects of Infant Diet on 9:45 269.8 Anti-inflammatory Properties of Tangeretin, Cholesterol/Bile Acid Synthesis and Absorption in Piglets. 5-Demethyltangeretin and Their Primary Metabolites. K.E. Mercer, M.E. Diaz-Rubio, S. Bhattacharyya, N. Sharma, S. Guo, X. Wu, J. Zheng, P. Dong, P. Qiu, H. Xiao. Univ. of L. Yeruva. Univ. of Arkansas for Med. Sci. and Arkansas Massachusetts Amherst and Univ. of Jinan, China. Children’s Nutr. Ctr. 9:30 267.7 Development of Nonalcoholic Fatty Liver in 270. OBESITY: CHILDHOOD Superoxide Dismutase-1 Knockout Mice Was Associated with OBESITY MANAGEMENT Altered Expression of Hepatic Fibroblast Growth Factor-21. D. Chakraborty, X.G. Lei. Cornell Univ. Minisymposium 9:45 267.8 Adipocyte-Specific Ablation of Long-Chain Acyl-CoA Synthetase-4 in Mice Protects against Diet- (Sponsored by: Obesity RIS) Induced Obesity-Associated Decreases in White Adipocyte Mon. 8:00 am—San Diego Convention Center, Room 29B Oxygen Consumption and Whole Body Energy Expenditure. E.A. Killion, D. Kong, A.S. Greenberg. USDA at Tufts Univ. Chaired: M. Cope and Tufts Univ. Sackler Sch. of Grad. Biomed. Sci. 8:00 270.1 Does Milk Portion Size or Energy Density Affect Preschool Children’s Lunch Intake? S.M.R. Kling, L.S. 268. INTERNATIONAL FORUM—TAIWAN Roe, B.J. Rolls. Penn State M 8:15 270.2 Effects of a Higher versus Lower Protein Diet O Moved to Sunday following session 132. on Weight Loss in Teenagers: Results from a Randomized Controlled Trial. J.W. Apolzan, D.S. Hsia, C.K. Martin. N 269. DBC: ANTI-INFLAMMATORY DIETARY Pennington Biomed., Baton Rouge. 8:30 270.3 Orbitofrontal Cortex Response to Food Portion BIOACTIVE COMPONENTS Size Is Linked with Obesogenic Appetitive Profile in Children. L.K. English, S.N. Fearnbach, M. Lasschuijt, S.J. Wilson, Minisymposium M. Tanofsky-Kraff, B.J. Rolls, K.L. Keller. Penn State, (Sponsored by: Dietary Bioactive Components RIS) Wageningen Univ., Netherlands and Uniformed Svcs. Univ. of Hlth. Sci., Bethesda. Mon. 8:00 am—San Diego Convention Center, Room 29A 8:45 270.4 A Randomized, Controlled, Parallel Study to Chaired: N. Ford Assess the Effects of Soy Protein on Body Composition and General Health Parameters in Healthy Children. M. Braun, C. 8:00 269.1 Anti-inflammatory and Anti-cancer Effects of Cook, R. Mukherjea, D. Liska. DuPont Nutr. & Hlth., St. Louis the Colonic Metabolites of Polymethoxyflavone. M. Wang, X. and Mérieux NutriSci., Addison, IL. Wu, M. Song, H. Xiao. Univ. of Massachusetts Amherst. 9:00 270.5 Network Social Support for Healthy and 8:15 269.2 Green Tea Extract Lowers NFκB-Mediated Obesogenic Behavior Influences Children’s Dietary Intake Inflammation during Nonalcoholic Steatohepatitis in Mice Fed and Weight Change during Family-Based Behavioral Obesity a High-Fat Diet Consistent with Reduced Toll-Like Receptor-4 Treatment. K.N. Balantekin, J.F. Hayes, R.P. Kolko, R.I. Stein, Signaling. J. Li, C. Chitchumroonchokchai, J.B. Kim, M.V. B.E. Saelens, R.R. Welch, M.G. Perri, K.B. Schechtman, L.H. Moller, R.S. Bruno. The Ohio State Univ. Epstein, D.E. Wilfley. Washington Univ. Sch. of Med., Univ. of 8:30 269.3 Dietary Sphingomyelin Attenuates Pittsburgh, Seattle Children’s Hosp., Univ. of Florida and Univ. Inflammation and Metabolic Dysfunction in Diet-Induced at Buffalo. Obese Mice. G.H. Norris, C.M. Porter, C. Jiang, C. Blesso. 9:15 270.6 Beverage Consumption among Advantest Univ. of Connecticut. Adolescents in the Teen FAD Study. M. Nezami, J. Sabate, L. 8:45 269.4 Tannase-Treated Grape Pomace Attenuates Beeson, G. Segovia-Siapco. Loma Linda Univ. IL-1β-Induced Inflammation in Caco-2 Cells. I. Martin, G. 9:30 270.7 A Father’s Response to Having a Child Who Is Macedo, J. Blumberg, C-Y.O. Chen. USDA at Tufts Univ. and Overweight/Obese. F.L. Battisti, H.E. Battisti. SUNY Broome, State Univ. of Campinas (UNICAMP), Brazil Binghamton and Marywood Univ., PA. 9:00 269.5 Gamma Tocotrienol Suppresses NLRP3 9:45 270.8 Initial Results from a Real-World Pediatric Inflammasome by Dual Mechanism of A20-Mediated Priming Specialty Weight Management Clinic in a Safety-Net Hospital. Inhibition and AMPK/Autophagy Axis Activation. Y. Kim, S. C.M. Lenders, K.D. Plourde, A.J. Manders, K. Ireland. Boston Chung. Univ. of Nebraska-Lincoln. Univ. Sch. of Med., Boston Med. Ctr. and Boston Univ. Sch. of 9:15 269.6 Docosahexaenoic Acid Inhibits Cerulein- Publ. Hlth. Induced Cytokine Expression by Activating Peroxisome Proliferator-Activated Receptor γ in Pancreatic Acinar Cells. E.A. Song, J.W. Lim, H. Kim. Col. of Human Ecol., Yonsei Univ., South Korea. 9:30 269.7 Periodontal Symptoms and Inflammation following Non-surgical Treatment and 4 Months of Fish Oil Supplementation. A. Coates, T. Fitzsimmons, B. Chee, B. Park, K. Kapellas, P. Howe, R. Lee, S. Ivanovski. Univ. of South Australia, Univ. of Adelaide, Univ. of Newcastle and Sch. of Dent. and Oral Hlth., Griffith Univ., Australia.

81 NUTRITION MONDAY

271. ENERGY AND MACRONUTRIENT METABOLISM: 272. VITMIN: B VITAMINS AND ONE- METABOLIC PHENOTYPING, METABOLOMICS CARBON METABOLISM AND BIOMARKERS Minisymposium Minisymposium (Sponsored by: Vitamins and Minerals RIS) (Sponsored by: Energy & Macronutrient Metabolism RIS) Mon. 8:00 am—San Diego Convention Center, Room 29D Mon. 8:00 am—San Diego Convention Center, Room 29C 8:00 272.1 Maternal Choline Supplementation Modulates Chaired: M.R. Panasevich Maternal and Fetal Choline Metabolism and Downregulates Inflammatory Gene Expression in a Mouse Model of Placental 8:00 271.1 Determination of CYP1A2 Activity in the U.S. Insufficiency. J.H. King, S.T. Kwan, J. Yan, X. Jiang, V.G. Population by Use of Caffeine Metabolite Ratios in Spot Urine Fomin, M.S. Roberson, M.A. Caudill. Cornell Univ. and Samples: NHANES 2009–2010. M.E. Rybak, M.R. Sternberg, Brooklyn Col. C-I. Pao, C.M. Pfeiffer. Ctr. for Dis. Control and Prevent. 8:15 272.2 Increased Circulating Trimethylamine N-Oxide, 8:15 271.2 Fasting Plasma Metabolomics Reveal Specific a Gut-Flora-Dependent Metabolite of Choline and Betaine Dietary Patterns in Sow-Fed Neonatal Piglets Compared to in Nonalcoholic Fatty Liver Disease Is Associated with High Soy- or Dairy-Based Formula Feeding. B.D. Piccolo, M.E. Serum Bile Acids. H-l. Zhu, X-y. Tan, Y. Liu, X-l. Chen. Sun Diaz-Rubio, K.E. Mercer, L. Yeruva. Arkansas Children’s Nutr. Yat-sen Univ., China. Ctr. and Univ. of Arkansas for Med. Sci. 8:30 272.3 Vitamin B12 and Placental Expression of 8:30 271.3 Impact of Vitamin D Status and High-Dose Transcobalamin in Pregnant Adolescents. A.J. Layden, Vitamin D3 Administration on the Plasma Metabolome in K.O. O’Brien, E.K. Pressman, T.R. Kent, J.L. Finkelstein. Critically Ill Adults. K. Perry-Walker, D.I. Walker, J.A. Alvarez, Cornell Univ., Univ. of Rochester Med. Ctr. and St. John’s Res. J.E. Han, J.L. Jones, L. Hao, S. Li, K. Uppal, V.T. Tran, L. Inst., Bangalore. Brown, V. Tangpricha, G.S. Martin, D.P. Jones, T.R. Ziegler. 8:45 272.4 Dietary Glycine Alters One-Carbon Metabolic Med. Col. of Georgia and Emory Univ. Kinetics In Vivo. Y-H. Huang, E-P.I. Chiang. Natl. Chung Hsing 8:45 271.4 Effects of HMB and Beta-Alanine Co- Univ., Taiwan. supplementation and Running Wheel Activity on Skeletal 9:00 272.5 Maternal Choline Supplementation Influences Muscle Morphometry and Metabolomics in Aged Rats. Placental Glucose Uptake and Metabolism in a Manner S.M. Garvey, J. Desai. Abbott Nutr., Columbus, OH and Univ. Dependent on Fetal Sex. S.T. Kwan, J.H. King, J. Yan, X. of Illinois at Urbana-Champaign. Jiang, J.S. Hutzler, M.S. Roberson, M.A. Caudill. Cornell 9:00 271.5 Ablation of BCO2 Leads to Increased Univ. and Brooklyn Col. Susceptibility to High Fat Diet-Induced Metabolic Disorders in 9:15 272.6 Cholesterol Homeostasis Alters One Carbon Mice. L. Wu, X. Guo, A. Davis, T.P. Soh, S. Clarke, E. Lucas, Metabolism In Vitro and In Vivo. H-A.S. Ko, Y-T.I. Wu, N-L.S. B. Smith, W. Wang, D. Medeiros, D. Lin. Oklahoma State Sou, E-P. Chiang. Natl. Chung Hsing Univ., Taiwan. Univ., Kansas State Univ. and Univ. of Missouri-Kansas City. 9:30 272.7 One-Carbon Metabolic Kinetics in Human 9:15 271.6 Altered Fatty Acid Metabolism Remodels the Disease Models. E.I. Chiang, Y-C. Wang, M-T. Wu, Y-J. Lin, Hypothalamic Metabolome to Stimulate Feeding Behavior in H-A. Ko, Y-H. Huang, N-L. Sou, Y-M. Chen, F-Y. Tang. Natl. BCO2 Knockout Mice. X. Guo, L. Wu, T. Soh, W. Chowanadisai, Chung Hsing Univ., Kao-Hsiung Med. Univ. and China Med. S. Clarke, E. Lucas, B. Smith, W. Wang, D. Medeiros, D. Univ., Taiwan. Lin. Oklahoma State Univ., Kansas State Univ. and Univ. of 9:45 272.8 Vitamin B12 Deficiency Defined Using Total Missouri-Kansas City. Cobalamin, Holo-transcobalamin II, and an Algorithm of Both 9:30 271.7 Obesity Is Associated with Distinct Changes in Total Cobalamin and Holo-transcobalamin II in Vegetarians, the Human Plasma Phospholipidome. C.A. Pickens, D. Jones, Vegans, and Omnivores. T. Arnold, J. Knurick, C. Johnston. J.I. Fenton. Michigan State Univ. Arizona State Univ. and Univ. of Nevada Las Vegas. 9:45 271.8 Use of Plasma Metabolomics at Diagnosis to Identify Metabolic Pathways Associated with Pulmonary Tuberculosis Clearance: A Pilot Study. E. Chong, J.K. Frediani, J.A. Alvarez, V. Tangpricha, H.M. Blumberg, D.P. Jones, T. Yu, T.R. Ziegler. Emory Univ.

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82 MONDAY NUTRITION

273. COMMUNITY AND PUBLIC HEALTH NUTRITION: 274. GLOBAL NUTRITION: NUTRITION- FOOD SECURITY AND ITS CONNECTIONS TO SENSITIVE PROGRAMS NUTRITION AND HEALTH SECTION II Minisymposium Minisymposium Mon. 8:00 am—San Diego Convention Center, Room 30B (Sponsored by: Community and Public Health Chaired: M. Ruel Nutrition RIS) Cochaired: S. Sinharoy Mon. 8:00 am—San Diego Convention Center, Room 30A

Chaired: J. Nelson-Peterman 8:00 274.1 Access and Adoption of Nutrition Specific and Nutrition Sensitive Messages in Ethiopia: A Qualitative 8:00 273.1 Ethnic Differences in Cumulative Exposure to Gendered Comparison. M. Min-Barron. Friedman Sch. of Food Insecurity and Risk of Childhood Asthma. L.D. Mangini, Nutr. Sci. and Policy, Boston. Y. Dong, M.D. Hayward, M.R. Forman. The Univ. of Texas 8:15 274.2 An Integrated Agriculture and Nutrition at Austin. Program in Burkina Faso Has Positive Intra-household 8:15 273.2 Perceived Benefits of Livestock Ownership Spillover Effects on Maternal and Child Nutritional Status, but among Female Smallholder Farmers of Mixed HIV Status in No Sustained Long-Term Improvements in Household Welfare. M Nyanza Province, Kenya. A. Maranga, S.E. Dumas`, P.E. L. Bliznashka, D.K. Olney, M.T. Ruel, R. Rawat, E. Becquey, O Mbullo, P. Wekesa, M. Onono, S.L. Young. Cornell Univ. and O. Birba. IFPRI, Washington, DC. Kenya Med. Res. Inst. (KEMRI), Nairobi. 8:30 274.3 Nutrition Sensitivity in Ethiopia’s Productive N 8:30 273.3 Food Insecurity Is Associated with Faster Safety Net Programme: Tracing the Movement of an Idea Cognitive Decline: Boston Puerto Rican Health Study. J. Wong, in Ethiopia’s Development Landscape. A.M. Warren, E.A. T. Scott, P. Wilde, Y. Li, K.L. Tucker, X. Gao. Brigham and Frongillo, S. Gillespie. Univ. of South Carolina, IFPRI, Women’s Hosp., Tufts Med. Ctr., Friedman Sch. of Nutr. Washington, DC and Transform Nutr., Brighton, U.K. Sci. and Policy, Tufts Univ., Univ. of South Florida, Univ. of 8:45 274.4 The Effects of a Nutrition-Sensitive Agricultural Massachusetts Lowell and Penn State. Intervention on Social Support, Food Security and Maternal 8:45 273.4 Food Insecurity Is Associated with Depression Self-Efficacy in Complementary Feeding. D. Toure, R. Rawat, and Stress among a Cohort of Pregnant Kenyan Women of R.J. Stoltzfus, D. Harvey, M. Mwanamwenge, D.L. Pelletier. Mixed HIV Status. I. Tsai, N.R. Krumdieck, S. Collins, E.M. Cornell Univ., IFPRI, Dakar and Concern, Zambia. Widen, P. Wekesa, M. Onono, S.L. Young. Cornell Univ., Weill 9:00 274.5 An Integrated Nutrition-Sensitive Health and Cornell Med., Columbia Univ. Med. Ctr. and Kenya Med. Res. Agriculture Intervention to Increase Egg Consumption among Inst., Kisumu. Infants and Young Children in Upper Manya Krobo, Ghana. 9:00 273.5 Food Insecurity Status and Mortality in Ontario, A. Atuobi-Yeboah, G.S. Marquis, E. Colecraft, R. Kanlisi, R. Canada. C. Gundersen, V. Tarasuk, J. Cheng, C. de Oliveira, Aryeetey, M. Klevor. Sch. of Publ. Hlth., Univ. of Ghana, McGill P. Kurdyak, N. Dachner. Univ. of Illinois, Urbana, Univ. of Univ., St. Anne de Bellevue and Heifer Ghana. Toronto and Ctr. for Addiction and Ment.l Hlth., Toronto. 9:15 274.6 Household Food Insecurity and Hunger in 9:15 273.6 Are Monthly Food Insecurity Assessments Selected Ethiopian Agricultural Communities: Examination of Necessary? A Longitudinal Analysis in Rural Zambia. M. Na, Supply and Demand Factors. G.A. Zello, G. Ersino, C.J. Henry, B.L. Caswell, S.A. Talegawkar, A. Palmer. Johns Hopkins N. Regassa. Col. of Pharm. & Nutr., Univ. of Saskatchewan Bloomberg Sch. of Publ. Hlth. and George Washington Univ. and Hawassa Univ., Ethiopia. 9:30 273.7 Food Insecurity and Young Child BMI Status in 9:30 274.7 Global Dietary Data Availability: Results of a the U.S. Affiliated Pacific Region: Findings from the Children’s Systematic Worldwide Search for Data on Dietary Intakes of Healthy Living Program. F. Li, R. Novotny, L.R. Wilkens, M.K. 55 Foods and Nutrients. G. Singh, M. Shulkin, K. Morrish, Fialkowski, R.R.T. Guerrero, P. Coleman, A. Bersamin, A. Tahira, D. Marsden, D. Mozaffarian. Friedman Sch. of Nutr. T. Fleming, J. Deenik. Univ. of Hawaii, Univ. of Guam, No. Sci. & Policy, Tufts Univ. Marianas Col., Univ. of Alaska Fairbanks and American Samoa 9:45 274.8 Large-Scale Television Campaign Associated Community Col., Pago Pago. with Higher Prevalence of Exclusive Breastfeeding in 9:45 273.8 Household Food Insecurity Access Scale and Vietnam. T.T. Nguyen, S. Alayón, P.H. Nguyen, A. Jimerson, Household Food Insecurity Access Prevalence as Predictor N. Hajeebhoy, J. Baker, E.A. Frongillo. FHI 360, Hanoi, FHI of Stunted Child and Overweight/Obese Mother in Urban 360, Save the Children and IFPRI, Washington, DC and Univ. Indonesia. T. Mahmudiono, D.R. Andrias, T.S. Nindya, H. of South Carolina. Megatsari, R. Rosenkranz. Kansas State Univ. and Univ. Airlangga, Indonesia

83 NUTRITION MONDAY

275. MATERNAL, PERINATAL AND PEDIATRIC: 276. NUTRITION EDUCATION: CHILDHOOD MAMMARY GLAND FUNCTION AND EFFECTS OBESITY PREVENTION OF MILK COMPONENTS ON INFANT HEALTH Minisymposium Minisymposium (Sponsored by: Nutrition Education and Behavioral Maternal, Perinatal and Pediatric RIS Science RIS)

Mon. 8:00 am—San Diego Convention Center, Room 30C Mon. 8:00 am—San Diego Convention Center, Room 30D

Chaired: S. Kelleher Chaired: A.R. Mobley

Cochaired: S. Lee Cochaired: A. Bersamin

8:00 275.1 ZnT2-Mediated Zn Transport Is Required 8:00 276.1 Cardiac Kids Club Improves Nutrition for Vesicle Acidification and Milk Secretion during Lactation. Knowledge, Dietary Intake, and Fitness among 4th & 5th S. Lee, O.C. Rivera, S.L. Kelleher. Penn State Hershey Col. Graders. M. Beck, M. Spence, K. Clay, C. Perry-Burst, S. of Med. Colby, K. Kavanagh. Univ. of Tennessee, Knoxville and Knox 8:15 275.2 The Effect of Genetic Variation on the Human County Schs. Milk Proteome. D.G. Lemay, K.L. Beck, E. Kwok, B.S. 8:15 276.2 Association of Fathers’ Income and Education Phinney, I. Korf. Univ. of California, Davis. Level with Childhood Obesity Risk Factors in Preschool Age 8:30 275.3 Effects of Metformin Exposure during Lactation Children. R.L. Vollmer, A. Kari, J.S. Foster, A.R. Mobley. on Mouse Offspring Metabolic Health and Maternal Lactation Illinois State Univ. and Univ. of Connecticut. Characteristics. B. Gregg, J. Brill, N. Botezatu, M.R. Smith. 8:30 276.3 Assessment of Circannual Variation in Relative Univ. of Michigan. Weight among Children in Wisconsin Using Electronic Health 8:45 275.4 Mammary Gland Structure and Functional Records. S. Bhutani, D. Schoeller, J. Kloke, L. Hanrahan. Changes in Mouse Model of Chronic Gestational Alcohol Univ. of Wisconsin-Madison Exposure. R.M. Amos-Kroohs, A.A. Cheng, R.D. Clugston, 8:45 276.4 Parental Intention to Engage in Healthier T-N. Huang, C-L. Yen, W.S. Blaner, S.M. Smith. Univ. of Beverage Practices: Effects of Gain-versus Loss-Framed Wisconsin-Madison and Columbia Univ. Messages. A. Zahid, M. Reicks. Univ. of Minnesota, St. Paul. 9:00 275.5 Acidic Human Milk Oligosaccharides Vary 9:00 276.5 Impact of the Shaping Healthy Choices Program across Populations and over Lactation. D.S. Newburg, C. on Students’ Lunchtime Fruit and Vegetable Consumption: Chen, A. Cline, A.L. Morrow. Boston Col. and Cincinnati A Randomized Controlled Trial of a Multicomponent School- Childrens Hosp. Med. Ctr. Based Nutrition Intervention. J.C. Taylor, R.E. Scherr, J.D. 9:15 275.6 Role of Human Milk Oligosaccharides in Feto- Linnell, G. Feenstra, M. Dharmar, S. Zidenberg-Cherr. placental Endothelial Function in Gestational Diabetes Mellitus. Univ. of California, Davis and Univ. of California Davis Hlth. E. Jantscher-Krenn, J. Aigner, U. Lam, M. van Poppel, L. Syst., Sacramento. Bode, G. Desoye. Med. Univ. of Graz, Univ. of Graz, Austria 9:15 276.6 Caregivers’ Estimations of 4-7-y-Old Children’s and UCSD. Food Neophobia and Eating Temperament and Observations 9:30 275.7 Term Infant Formula Supplemented with of Children’s Food Refusals. S.L. Johnson, W.J. Gavin, P. Human Milk Oligosaccharides (2’Fucosyllactose and Lacto-N- Davies, B. Taylor, R.E. Boles, L.L. Bellows. Univ. of Colorado neotetraose) Shifts Stool Microbiota and Metabolic Signatures Anschutz Med. Campus and Colorado State Univ. Closer to That of Breastfed Infants. P. Steenhout, P. Sperisen, 9:30 276.7 Television Food Advertisement Exposure and F-P. Martin, N. Sprenger, S. Wernimont, S. Pecquet, B. FTO Genotype in Relation to Excess Consumption in Children. Berger. Nestlé Hlth. Sci., Vevey, Nestlé Inst. of Hlth. Sci., D. Gilbert-Diamond, J. Emond, R.K. Lansigan, K. Rapuano, Lausanne, Nestlé Res. Ctr., Lausanne, and Nestlé Nutr., King W. Kelley, T. Heatherton, J. Sargent. Geisel Sch. of Med. at of Prussia and Vevey, Switzerland. Dartmouth and Dartmouth Col. 9:45 275.8 Unlike Adipokines, Insulin Concentrations in 9:45 276.8 Using a Humanoid Robot along with a Human Milk Surpass Those in Maternal Circulation, Are Higher Registered Dietitian in an After-School Program to Promote among Overweight Women, and Are Associated with Maternal Healthy Eating Habits and Physical Activity in School-Aged Insulin Resistance. B.E. Young, C. Westcott, C. Chartier- Children. N. Mikati, M. Eltoukhy, F. Huffman. Florida Intl. Univ. Logan, T. Hernandez, L. Barbour, J. Friedman, N.F. Krebs. and Univ. of Miami. Univ. of Colorado Sch. of Med.

84 MONDAY NUTRITION

277. THE PRESIDENTIAL SYMPOSIUM: SYSTEMS 281. DIETARY BIOACTIVE COMPONENTS RIS APPROACHES IN NUTRITION BUSINESS MEETING AND HOT TOPIC: PROCESSING EFFECTS ON BIOACTIVE Special Session FOOD COMPONENTS AND THE IMPACT ON

Mon. 10:30 am—San Diego Convention Center, TRANSLATING LABORATORY STUDIES TO Ballroom 20D HUMAN HEALTH OUTCOMES

Chaired: P.J. Stover RIS Forum

Cellular and Molecular Nutrition Mon. 12:45 pm—San Diego Convention Center, Room 31ABC

10:30 Achieving Precision Nutrition in Public Health, Dietary Chaired: J.D. Lambert Guidance and Food Systems: Mathematical and Computational Approaches from Complexity Systems. R. Hammond. Brookings Inst. 282. DIET AND CANCER RIS BUSINESS MEETING 10:50 Small Data and mHealth. D. Estrin. Cornell Tech. AND HOT TOPIC: RED MEAT, PROCESSED 11:10 100K Wellness Project: The First-ever Broadly MEAT, AND CANCER: WHAT’S NEXT? Integrative Approach to Scientific Wellness. N. Price. M Inst. for Syst. Biol. RIS Forum O 11:30 Metabolomics Approaches to Classifying Patient Populations and Identifying Responders and Non- Mon. 1:00 pm—San Diego Convention Center, Room 32AB N responders to Nutrition Interventions. K. Hiller. Chaired: E. Cho Luxembourg Ctr. for Syst. Biomed. 11:50 Panel Discussion. 283. MATERNAL, PERINATAL AND PEDIATRIC RIS/ 278. E.V. MCCOLLUM INTERNATIONAL ISRHML BUSINESS MEETING AND LUNCHEON LECTURESHIP IN NUTRITION RIS Forum Award Lecture Maternal, Perinatal and Pediatric RIS Mon. 1:45 pm—San Diego Convention Center, (Cosponsored by: The International Society for Research Ballroom 20D in Human Milk and Lactation (ISRHML)) 1:45 R.J. Stoltzfus. Cornell Univ Mon. 12:45 pm—San Diego Convention Center, Room 28DE

279. NUTRITION TRANSLATION RIS BUSINESS Chaired: S. Kelleher MEETING, KEYNOTE PRESENTATION AND NETWORKING EVENT 284. HEALTH RECOMMENDATIONS FOR DIETARY RIS Forum SUGARS: WHY CAN’T WE ALL AGREE?

(Sponsored by: Nutrition Translation RIS) Symposium

Mon. 1:00 pm—San Diego Convention Center, Room 33BC Mon. 3:00 pm—San Diego Convention Center, Ballroom 20D Chaired: M. Braun Chaired: D.M. Bier

280. MEDICAL NUTRITION COUNCIL BUSINESS Cochaired: D.M. Klurfeld MEETING Clinical and Translational Nutrition RIS Forum 3:00 Science Basis Used to Develop Recommendations Regarding Dietary Sugars: Challenges of Using Available (Sponsored by: Medical Nutrition Council) Sugars Data for Recommendations. J. Sievenpiper. Mon. 1:00 pm—San Diego Convention Center, Room 33A Univ. of Toronto. 3:18 Metrics Used by the 2015 DGAC to Develop Dietary Chaired: C.W. Bales Recommendations Regarding Sugars in the Diet. M. Neuhouser. Fred Hutchinson Cancer Res. Ctr. 3:36 Metrics Used to Develop Dietary Recommendations Regarding Sugars in Diet. T. Nicklas. Baylor Univ. 3:54 Strength of Dental Caries Evidence Used to Formulate Recommendations for Dietary Sugars Intake. D. Zero. Indiana Univ. Sch. of Dent. 4:12 Development of Scientifically Valid Health Recommendations Regarding Dietary Sugars in the Current Regulatory Environment. B. Schneeman. USAID. 4:30 Panel Discussion. 85 NUTRITION MONDAY

285. POSTPRANDIAL INFLAMMATION: ENDOTOXIN 3:15 287.2 Gene Expression of Vitamin D Regulatory OR FREE FATTY ACIDS? Enzymes in Renal Tissue of Growing Pigs Is Modulated by Maternal Dietary Vitamin D Concentrations. L. Amundson, T. Symposium Crenshaw. Univ. of Wisconsin-Madison. 3:30 287.3 Consequences of Maternal Iron-Deficiency: Mon. 3:00 pm—San Diego Convention Center, Room Fetal Anemia, and Hypoxia in Select Tissues of the Conceptus. 31ABC A. Woodman, Y. Mansour, S. Bourque. Univ. of Alberta. Chaired: D.H. Hwang 3:45 287.4 Dysfunction of Insulin-Like Growth Factor Signaling in Skeletal Muscles of Low Birth Weight Neonatal Cochaired: K.L. Fritsche Pigs. Y. Chen, H. Zhu, S.R. McCauley, K.R. Oliver, K.A. Tinnesz, S.W. El-Kadi. VPI and State Univ. Cellular and Molecular Nutrition 4:00 287.5 Metabolic Phenotype and Increased Adiposity 3:00 Postprandial Inflammation: Overview. P. Calder. Univ. in a Mouse Model of Chronic Gestational Alcohol Exposure. of Southampton. R.M. Amos-Kroohs, D.W. Nelson, C-L.E. Yen, S.M. Smith. 3:25 High Fat Diet-induced Postprandial Endotoxemia. Univ. of Wisconsin-Madison. M-C. Michalski. INRA. 4:15 287.6 Postnatal Changes in Low Birth Weight Piglets 3:50 Plasma Free Fatty Acids: Major Determinant for Fed a High-Energy Diet. S.R. McCauley, Y. Chen, K.R. Oliver, Postprandial Inflammation. D. Hwang. Western R.P. Rhoads, S. El-Kadi. VPI and State Univ. Human Nutri. Res. Ctr. (ARS/USDA), UC-Davis. 4:30 287.7 Effects of DHA and Choline Supplementation 4:15 Methodological Challenges Associated with and on Developmental Outcomes of the Typically Developing Possible Solutions to Measuring Endotoxin in Plasma/ and Fetal Alcohol Exposed Rat Pup. L.G. Canipe III, T.W. Sera Samples. K. Fritsche. Univ. of Missouri. Jackson, C.L. Cheatham. Univ. of North Carolina at Chapel Hill, Kannapolis. 286. MAKING YOUR SCIENTIFIC DISCOVERIES 4:45 287.8 Gestational Exposure to Maternal Obesity KNOWN: BEST PRACTICES FOR EFFECTIVE Influences β3-Adrenergic Agonist-Induced Beiging of White Adipose Tissue in Offspring. K. Shankar, P. Kang, Y. Zhong, AND CREDIBLE COMMUNICATION K.M. Thakali, U.D. Wankhade. Arkansas Children’s Nutr. Ctr., Little Rock. Symposium

Mon. 3:00 pm—San Diego Convention Center, Room 33BC 288. INTERNATIONAL FORUM – CHINA

Chaired: M. Braun International Forum Cochaired: M.N. Lesser (Organized and Sponsored by: the Chinese Nutrition Education Society and North American Chinese Society for Nutrition) 3:00 Time in the Public Eye: Maintaining Credibility While Using Your Voice. K. Sollid, A. Brown, C. Weaver, Mon. 3:30 pm—San Diego Convention Center, Room 32AB J. Hill, A. Beaudreault. IFIC, Univ. Alabama at Chaired: C. Wu Birmingham, Purdue Univ., Univ. of Colorado Anschutz Med. Campus, Univ. of California-Davis. Cochaired: C. Guo 3:30 Beyond the Bench: Communicating Science through Stories. J. Storlie. Storlietelling LLC. 3:30 CNS – NACSN Collaboration: Training Programs. 4:40 Using Your Voice Now: Next Steps and Future Directions. Y. Wang. Univ. at Buffalo, SUNY A.C. Ross. Pennsylvania State Univ. 3:40 CNS – NACSN Collaboration: Research Enhancement. H. Mo. Georgia State Univ. 3:50 Introduction of the First International Nutrition 287. EXPERIMENTAL ANIMAL NUTRITION: Congresses. C. Guo. Chinese Nutr. Society ANIMAL MODELS OF FETAL 4:00 Introduction of Chinese Dietary Reference Intakes. NUTRITION, PROGRAMMING AND Y. Cheng. Chinese Nutr. Society NEONATAL DEVELOPMENT 4:15 Nutrition and Global Health. TBD. North American Chinese Society for Nutr. Minisymposium 4:30 S-Adenosyl-homocyeteine as An Intermediate Metabolite of Methinion and Atherosclerotic Cardiovascular (Sponsored by: Experimental Animal Nutrition RIS) Diseases. W. Ling. Chinese Nutr. Society Mon. 3:00 pm—San Diego Convention Center, Room 33A 4:45 Optimal Pregnant Weight Gain and Dietary Status of Women in A Urban Population from Eastern Jiangsu Chaired: R.N. Dilger of China. Z. Wang. Chinese Nutr. Society, Nanjing Cochaired: S. Jacobi Med. Univ.

3:00 287.1 Maternal High-Fructose in Pregnancy Adversely Affects Morphological Aspects of the Placenta. A. Song, S. Astbury, A. Hoedl, N. Coursen, W. Dixon, D. Hemmings, R. Bell. Univ. of Alberta.

86 MONDAY NUTRITION

289. DBC: HUMAN INTERVENTION STUDIES WITH 290. NUTRITIONAL EPIDEMIOLOGY: DIETARY BIOACTIVE COMPONENTS EPIDEMIOLOGICAL RESEARCH ADDRESSING DIET AND HEALTH OUTCOMES Minisymposium Minisymposium (Sponsored by: Dietary Bioactive Components RIS) (Sponsored by: Nutritional Epidemiology RIS) Mon. 3:00 pm—San Diego Convention Center, Room 29A Mon. 3:00 pm—San Diego Convention Center, Room 29B Chaired: A.P. Neilson Chaired: L. Troy Cochaired: A. BASU Cochaired: A.E. Millen 3:00 289.1 Green Tea Extract and Catechol-O- Methyltransferase (COMT) Genotype Modify Fasting Serum 3:00 290.1 Prospective Relations between Red Blood Cell Insulin and Plasma Adiponectin Concentrations in a Randomized n-6 and n-3 Fatty Acid Composition and Cognitive Function Controlled Trial of Overweight and Obese Postmenopausal among Older Puerto Rican Adults. S.J. Bigornia, T.M. Scott, Women. A. Dostal, H. Samavat, L. Espejo, A. Arikawa, N.R. W.S. Harris, K.L. Tucker. Univ. of Massachusetts Lowell, USDA Stendell-Hollis, M.S. Kurzer. Univ. of Minnesota, St. Paul, at Tufts Univ. and Sanford Sch. of Med., Univ. of South Dakota. M Univ. of North Florida and Central Washington Univ. 3:15 290.2 Plasma PLP Concentration and Depressive 3:15 289.2 Systematic Review of Anthocyanins and Symptomatology in Older Latino Adults: A Longitudinal Analysis O Markers of Cardiovascular Disease. T.C. Wallace, M. Slavin, with Time-Varying Covariates. S.P. Arevalo, T.E. Scott, L.M. N C.L. Frankenfeld. George Mason Univ. Falcon, K.L. Tucker. Univ. of Massachusetts Lowell and Tufts 3:30 289.3 Green Tea Extract Supplementation Modifies Univ. Sch. of Med. Circulating Lipids In Postmenopausal Women: A Randomized, 3:30 290.3 A Folate, Vitamin B12 and Homocysteine- Placebo-Controlled Clinical Trial. H. Samavat, A. Rose, Related Dietary Pattern and Risk of Subclinical Atherosclerosis: A. Dostal, R. Wang, A. Wu, J-M. Yuan, M. Kurzer. Univ. of Findings from the MRC National Survey of Health and Minnesota, St. Paul, Univ. of Pittsburgh Cancer Inst., Univ. of Development. J. Maddock, G.L. Ambrosini, S. Ray, NSHD So. California Keck Sch. of Med. and Univ. of Pittsburgh Grad. Study Team. MRC Human Nutr. Res., Univ. of Cambridge, Sch. of Publ. Hlth. Univ. of Western Australia Sch. of Popul. Hlth. and Univ. 3:45 289.4 Changes in Dietary Profiles, Markers of Col. London. Cardiometabolic Health and Cognitive Function following 12 3:45 290.4 Plasma trans Palmitoleic Acid and Weeks of Peanut Consumption. A. Coates, J. Barbour, J. Cardiometabolic Risk Factors in Youth with Type 1 Diabetes: Buckley, J. Bryan, P. Howe. Univ. of South Australia and Univ. SEARCH Nutrition Ancillary Study. N.S. The, I.B. King, J.L. of Newcastle, Australia. Crandell, S. Couch, B. Tzeel, A.D. Liese, D. Dabelea, E. 4:00 289.5 The Effect of Oat Beta-Glucan on Clinical Mayer-Davis. Furman Univ., Univ. of New Mexico, Univ. Lipid Markers for Cardiovascular Disease Risk Reduction: A of North Carolina at Chapel Hill, Univ. of Cincinnati Col. of Systematic Review & Meta-analysis of Randomized Controlled Allied Hlth., Univ. of South Carolina and Univ. of Colorado Trials. H.V.T. Ho, J.L. Sievenpiper, A.L. Zurbau, S. Blanco Denver, Aurora. Mejia, E. Jovanovski, F. Au Yeung, A.L. Jenkins, V. Vuksan. 4:00 290.5 Protein Intake and Risk of Hip Fractures in St. Michael’s Hosp., Toronto. Post-Menopausal Women and Men Over 50 Years. T. Fung, W. 4:15 289.6 Effect of 3 Probiotic Strains on Bile Acids and Willett, D. Feskanich. Simmons Col., Harvard T.H. Chan Sch. Glucose Metabolism in Healthy Adults: A Randomized, Double- of Publ. Hlth. and Channing Div. of Network Med., Boston. Blind Placebo-Controlled Crossover Study. T. Culpepper, C.C. 4:15 290.6 Vitamin D and Ovarian Reserve and Rowe, C. Nieves, S-A. Girard, M. Christman, S. Chung, Fecundability among Women with Proven Fecundity. T.A. Thompkins, B. Langkamp-Henken. Univ. of Florida, S.L. Mumford, R. Silver, L.A. Sjaarda, N. Galai, J. Stanford, Lallemand Hlth. Solutions, Montreal, MCC Stat. Consulting A. Lynch, L. Lesher, N. Perkins, J. Wactawski-Wende, R. LLC, Gainesville and Univ. of Nebraska-Lincoln. Garbose, K. Kim, K. Michels, E. Schisterman. NICHD, NIH, 4:30 289.7 Probiotic Lacidofil® STRONG Mitigates the Rockville, MD, Univ. of Utah, Univ. of Haifa, Univ. of Colorado Antibiotic-Induced Alteration of the Fecal MicroRNA Signature Aurora, Univ. at Buffalo and Johns Hopkins Univ. in Healthy Humans. A. Taibi, E.M. Comelli, S-A. Girard, T.A. 4:30 290.7 Calibrated Total Sugars Intake and Risk of Tompkins. Univ. of Toronto, Ctr. for Child Nutr. and Hlth., Type 2 Diabetes in the Women’s Health Initiative Observational Toronto and Lallemand Hlth. Solutions, Monreal. Study. N. Tasevska, M. Pettinger, V. Kipnis, D. Midthune, L. 4:45 289.8 Preclinical and Clinical Trials for Investigating Tinker, N. Potischman, M. Neuhouser, J. Beasley, L. Van the Effect of A1 versus A2 Beta-Casein Containing Diet on Horn, B. Howard, S. Liu, J. Manson, J. Shikany, C. Thomson, Glutathione Antioxidant Status. M.S. Trivedi, R. Deth, Y. R. Prentice. Arizona State Univ., Fred Hutchinson Cancer Res. Zhang. Nova Southeastern Univ. and Northeastern Univ. Ctr., NCI, NIH, Albert Einstein Col. of Med., Northwestern Univ., Chicago, Medstar Hlth. Res. Inst., Hyattsville, MD, Brown Univ., Harvard Med. Sch., Univ. of Alabama at Birmingham and Univ. of Arizona. 4:45 290.8 Eating Episodes and Low Calorie Sweetener Intake in the U.S. Adult Population: NHANES 2007- 2012. B.P. Marriott, K.J. Hunt, A.M. Malek, D. Greenberg, J. St. Peter. Med. Univ. of South Carolina and PepsiCo, NY

87 NUTRITION MONDAY

291. ENERGY AND MACRONUTRIENT METABOLISM: 292. VITMIN: MICRONUTRIENT INTERVENTION OBESITY AND THE METABOLIC SYNDROME AND TRACE ELEMENT TRANSPORT AND (CO-SPONSOR: OBESITY RIS) HOMEOSTASIS IN HEALTH AND DISEASE

Minisymposium Minisymposium (Sponsored by: Energy & Macronutrient Metabolism RIS) (Sponsored by: Vitamins and Minerals RIS)

Mon. 3:00 pm—San Diego Convention Center, Room 29C Mon. 3:00 am—San Diego Convention Center, Room 29D

Chaired: B. Piccolo Chaired: N. Gletsu-Miller

Cochaired: E. Reverri Cochaired: J.K. Urbanek

3:00 291.1 Protection against Insulin Resistance in 3:00 292.1 Lack of Intestinal Divalent Metal-Ion Obesity Is Accompanied by Low Rates of Systemic Fatty Transporter 1 Perturbs Copper Homeostasis in Mice. X. Wang, Acid Mobilization and Attenuated Markers of Fibrosis and S. Flores, J-H. Ha, C. Doguer, J.F. Collins. Univ. of Florida. Inflammation in Adipose Tissue. D.W. Van Pelt, A.Y. Wang, J.F. 3:15 292.2 Responses of Total and Bioavailable Horowitz. Univ. of Michigan. 25-Hydroxyvitamin D and Factors Modifying the Responses: 3:15 291.2 High-Fat Diet-Induced Obesity Suppresses A Randomized, Placebo-Controlled Trial of Vitamin D3 Adaptive Thermogenesis via Toll-Like Receptor 4-Mediated Supplementation in an Asian Population. X. Lin, P. Yao, L. Sun, Endoplasmic Reticulum Stress. M. Okla, W. Wang, S. Chung. H. Li. Shanghai Insts. for Biol. Sci., CAS. Univ. of Nebraska-Lincoln. 3:30 292.3 Hepcidin Attenuates Zinc Efflux in Caco-2 3:30 291.3 A High Fat Diet Containing Fish Oil Reduces Cells. S.R. Hennigar, J.P. McClung. U.S. Army Res. Inst. of Weight Gain and Metabolic Syndrome Associated with Envrn. Med., Natick, MA. Glucocorticoid Therapy. M. van der Merwe, L. Beech, S. 3:45 292.4 High Dietary Iron Intake Impairs Growth and Godwin, R. Buddington, K. Ringwald-Smith. Sch. of Hlth. Causes Copper Deficiency in Sprague-Dawley Rats. J-H. Ha, Studies, Univ. of Memphis and St Jude Children’s Res. Hosp. C. Doguer, S. Zhao, X. Wang, S.R. Flores, J.F. Collins. Univ. 3:45 291.4 Effect of Caloric Restriction and Dietary of Florida. Composition on Liver Triglyceride Content in Subjects with 4:00 292.5 Iron Status and Regulation in High-Risk Abdominal Obesity: The Wageningen Belly Fat Study. Pregnant African American Women. L. Welke. Univ. of Illinois M. Mensink, S. Schutte, I. Chatindiara, D. Esser, E. Siebelink, at Chicago. L. Afman. Wageningen Univ., Netherlands. 4:15 292.6 The Ferroxidase Hephaestin Is Required for 4:00 291.5 Intake of Genistein and Daidzein Ameliorates Optimal Iron Absorption in Weanling Mice, but Is Dispensable Adiposity and Metabolic Syndrome in High Fat Fed for Enhanced Iron Absorption in Adults. C. Doguer, J-H. Ha, M. C57BL/6JMice. T. Luo, O. Miranda, A. Adamson, N.F. Shay. Alla, J.F. Collins. Univ. of Florida Oregon State Univ. 4:30 292.7 Trace Element Distribution in Flatiron Mice, a 4:15 291.6 High Phosphorus Diet Mitigates Impairments Genetic Model of Human Ferroportin Disease. Y.A. Seo, M. in Lipid and Glucose Metabolism Associated with Diet-Induced Wessling-Resnick. Harvard Sch. of Publ. Hlth. Obesity in Male Sprague Dawley Rats. M. Bassil, N. Zeeni, 4:45 292.8 Impact of Milk-Based Micronutrient N. Farran, O. Obeid. Lebanese American Univ. and American Supplementation on Zinc, Iron, and Vitamin A Deficiencies in Univ. of Beirut. School Children in Quito, Ecuador. D. Guevara, S. Reyes, D. 4:30 291.7 A Short-Term Transition from a High-Fat Diet Anarumba, M. López, S. Cevallos, E. Montenegro, N. Flores, to a Normal-Fat Diet before Pregnancy Exacerbates Female M. Fornasini, M.E. Baldeon. Univ. de las Americas, Ecuador Mouse Offspring Obesity. L. Xie, Q. Fu, P. Olson, K. Zhang. Univ. of North Dakota and Wuhan, China. 293. AGING: NUTRITION AND 4:45 291.8 Disparities in the Incidence of Hypertension CARDIOMETABOLIC HEALTH in Youth. C. Koebnick, M.F. Daley, Y.D. Mohan, K. Reynolds, X. Li, M.A. Sidell, A.H. Porter, J. Handler, S.R. Daniels, Minisymposium B.D. Kuizon. Kaiser Permanente So. California, Pasadena, Kaiser Permanente Colorado, Denver, Kaiser Permanente Los (Sponsored by: Aging and Chronic Disease RIS) Angeles Med. Ctr., Kaiser Permanente Anaheim Med. Ctr. and Mon. 3:00 pm—San Diego Convention Center, Room 30A Children’s Hosp. Colorado, Aurora. Chaired: C.C. Tangney

Cochaired: K. Starr

3:00 293.1 Effects of Polyphenolic-Rich Dark Chocolate and Almonds on Cardiovascular Risk Factors in Overweight and Obese Adults. Y. Lee, C. Berryman, S. West, C-Y.O. Chen, J. Blumberg, A. Preston, K. Lapsley, J. Fleming, P. Kris- Etherton. Penn State, USDA at Tufts Univ., Hershey Co., PA and Almond Bd. of California, Modesto. 3:15 293.2 Incorporation of Almonds in a Cholesterol- Lowering Diet Improves Non-ABCA1-Mediated Cholesterol Efflux in Normal Weight Adults. C.E. Berryman, J.A. Fleming, P.M. Kris-Etherton. Penn State

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3:30 293.3 Daily Almond Consumption Reduces Fasting 3:30 294.3 Complementary Feeding Is Positively Related Total, LDL and non-HDL Cholesterol and Body Fat Mass in with Family Care, Care for Women, and Improved Water and Healthy Young Korean Subjects: A Randomized Controlled Sanitation among Populations. S. Basnet, E.A. Frongillo, S. Trial. H. Park, Y. Liu, Y. Song, H-S. Kim. ICAN Nutr. Educ. and Kulkarni, F. de Castro. Univ. of South Carolina and Mexico Res., Seoul and Sookmyung Women’s Univ., South Korea. Natl. Inst. of Publ. Hlth., Cuernavaca. 3:45 293.4 Effect of a 1-Year Walnut Supplementation 3:45 294.4 Differences in Child Feeding and Handwashing on Blood Lipids among Older Individuals: Findings from the Practices within the Context of a Randomized Controlled Trial of Walnuts and Healthy Aging Study. E. Ros, S. Rajaram, A. Nutrition, Water, Sanitation, and Hygiene Interventions among Sala-Vila, M. Serra-Mir, C. Valls-Pedret, M. Cofán, I. Roth, M. Low-Income Bangladeshi Mothers. K. Jannat, S.P. Luby, L. Doménech, T. Freitas, C. Calvo, E. Haddad, J. Sabaté. Hosp. Unicomb, K.K. Das, E. Leontsini, M. Rahman, P. Winch, C. Clin., Barcelona and Loma Linda Univ. Stewart. icddr, Bangladesh, Stanford Univ., Johns Hopkins 4:00 293.5 Adherence to a Mediterranean Diet, and Bloomberg Sch. of Publ. Hlth. and Univ. of California Davis. Effects on Cardiometabolic Health in Older Australian:; Results 4:00 294.5 Food Sources of Total Energy, Total Sugars from the MedIterranean Diet for Cognition and Cardiovascular and Added Sugars among Infants, Toddlers and Preschoolers Health in the Elderly (MedLey) Trial. C.R. Davis, J. Bryan, Living in Mexico: Findings from the 2012 Mexican National C. Wilson, J. Hodgson, R. Woodman, K. Murphy. Univ. Health and Nutrition Survey. D. Deming, M. Afeiche, K. Reidy, of South Australia, Sch. of Med., Flinders Univ. and Univ. of A. Eldridge, S. Villalpando-Carrión. Nestlé Nutr. Global R&D, Western Australia. NJ, Nestle Res. Ctr., Lausanne, Children’s Hosp. of Mexico M 4:15 293.6 Validation of a Sodium Screener in Two and Nestlé Infant Nutr., Mexico City. O Samples. C.C. Tangney, H.C. Rasmussen, J. Rusch, O. 4:15 294.6 Snacking Starts Early and Is Prevalent among N Moss, L.A. Cerwinske, C. Richards, M. Li, B.M. Appelhans. Infants, Toddlers and Preschoolers in Mexico. D. Deming, M. Rush Univ. Med. Ctr. Afeiche, K. Reidy, A. Eldridge, S. Villalpando-Carrión. Nestlé 4:30 293.7 Ldlr-/- Mice Lacking PEMT Have Elevated Nutr. Global R&D, Floral Park, NJ, Nestle Res. Ctr., Lausanne, Plasma Trimethylamine-Oxide Levels but Are Protected from Children’s Hosp. of Mexico, Natl. Inst. of Hlth., Mexico City and High Fat Diet-Induced Atherosclerosis. R. Jacobs, Y. Zia, A. Nestlé Infant Nutr., Mexico City. Rajabi, S. Mi, K-A. Leonard, Y-Y. Zhao, C. Field, J. Curtis, J. 4:30 294.7 Household Food Insecurity and Complementary van der Veen. Univ. of Alberta. Feeding in Malawi. E. Faerber, J. Weiss, E. Kedera, A. 4:45 293.8 Inactive Matrix Gla Protein Is Associated with Webb Girard. Emory Univ. and Concern Worldwide/US, New Arterial Stiffness and Vascular Endothelial Function in African- York, NY. American Hemodialysis Patients. M.E. Fain, J. Nguyen, G.K. 4:45 Conclusion. Kapuku, W.D. Paulson, J.J. White, Y. Dong, N.K. Pollock. Med. Col. of Georgia, Georgia Regents Univ. 295. MATERNAL, PERINATAL AND PEDIATRIC: EARLY CHILDHOOD NUTRITION 294. GLOBAL NUTRITION: IMPROVING INFANT FEEDING PRACTICES OF Minisymposium VULNERABLE POPULATIONS Maternal, Perinatal and Pediatric RIS

Minisymposium Mon. 3:00 pm—San Diego Convention Center, Room 30C

(Sponsored by: Global Nutrition Council) Chaired: D. Sela

(Cosponsored by: Maternal, Perinatal and Pediatric RIS) Cochaired: E. Jantscher-Krenn

Mon. 3:00 pm—San Diego Convention Center, Room 30B 3:00 295.1 From Carrots to Peas and Parsnips:

Chaired: M.E. Bentley Programming Flexibility through Guided Multisensory Exploration in an Early Childhood Environment. S. Kannan, Cochaired: S. Syed H.B. Ganguri, Z. Qamar, U. Lakshmanan, C. Wittcopp. So. Illinois Univ. Carbondale, Kronsys, Raleigh, Texas A&M Univ. 3:00 294.1 Modeling Pathways from a Behavior Change and Baystate Med. Ctr., Springfield, MA. Communications Intervention to Complementary Feeding 3:15 295.2 INSIGHT Study Parenting Intervention to Outcomes: A Proof of Concept Study. A. Zongrone, P. Menon, Prevent Childhood Obesity Improves Patterns of Dietary G. Pelto, J-P. Habicht, K.M. Rasmussen, M. Constas, A. Exposures in Infants. E.E. Hohman, J.S. Savage, I.M. Paul, Khaled, K.K. Saha, R.J. Stoltzfus. IFPRI, Washington, DC, L.L. Birch. Penn State, Penn State Col. of Med. and Univ. Cornell Univ. and BRAC Univ., Bangladesh. of Georgia. 3:15 294.2 A Large-Scale Behavior Change Initiative 3:30 295.3 Parental Knowledge, Perceptions and to Improve Infant and Young Child Feeding Had Positive Consumption of Milk and Alternatives Relates to Intakes of Impact on Language and Motor Development in Bangladesh. Young Children 2-8 Years of Age. N.R. Brett, C.A. Vanstone, E. Frongillo, P. Nguyen, K. Saha, T. Sanghvi, K. Afsana, J.L. Maguire, F. Rauch, H.A. Weiler. Sch. of Dietet. and Human R. Haque, J. Baker, M. Ruel, R. Rawat, P. Menon. Univ. of Nutr., McGill Univ., Li Ka Shing Inst. of St. Michael’s Hosp., South Carolina, IFPRI and FHI360, Washington, DC and Univ. of Toronto and Shriners Hosp. for Children, Montreal. BRAC, Bangladesh. 3:45 295.4 Preschool Children’s Food Involvement Is Related to Fruit and Vegetable Intake. J.M. Jarick, B.H. Fiese. Univ. of Illinois at Urbana-Champaign.

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4:00 295.5 Effects of Omega-3 Supplementation during 4:15 296.6 Feeding a Maternal Diet Enriched in Pregnancy and Youth on Neurodevelopment and Cognition Docosahexaenoic Acid to Lactating Dams Improves the Ex in Childhood: A Systematic Review and Meta-analysis. M.L. Vivo Tolerance Response to Egg Protein in Suckled Pups. Shulkin, L. Pimpin, D. Bellinger, S. Kranz, C. Duggan, W. C. Richard, E.D. Lewis, S. Goruk, C.J. Field. Univ. of Alberta. Fawzi, D. Mozaffarian. Friedman Sch. of Nutr. Sci. and Policy, 4:30 296.7 Effects of a Randomized, Controlled Trial Tufts Univ., Boston Children’s Hosp., Harvard Med. Sch. and of Daily Vitamin D3 Supplementation during Pregnancy on Harvard T.H. Chan Sch. of Publ. Hlth. Regulatory Immunity and Inflammation. M. Zerofsky, B. 4:15 295.6 Infant Feeding Practices in a Diverse Group of Jacoby, T.L. Pedersen, C.B. Stephensen. USDA, Davis and Women: The Healthy Start Study. J.L. Kaar, K.A. Sauder, T.L. UC Davis Med. Ctr., Sacramento. Crume, A.L.B. Shapiro, A.P. Starling, D. Dabelea. Sch. of Med. 4:45 296.8 Effect of a Diet Rich in Whole Grains on and Colorado Sch. of Publ. Hlth., Univ. of Colorado, Aurora. Gut Microbiota, and Immune and Inflammatory Markers of 4:30 295.7 The Early Life Predictors of a Dietary Pattern Healthy Adults. S.M. Vanegas, M. Meydani, J.B. Barnett, A. Linked with Greater Metabolic Risk in Adolescence and Kane, B. Goldin, D. Wu, J.P. Karl, C. Brown, P. Vangay, D. Tracking of Its Food Components. G. Appannah, G.K. Pot, Knights, L. Li, S.S. Jonnalagadda, M. Thomas, E. Satlzman, W.H. Oddy, S.A. Jebb, G.L. Ambrosini. Univ. Putra Malaysia, S.N. Meydani. USDA and Sch. of Med., Tufts Univ., Univ. of MRC Human Nutr. Res., Cambridge, Sch. of Med., King’s Col. Minnesota, Minneapolis and General Mills, Minneapolis. London, VU Univ. Amsterdam Fac. of Earth and Life Sci., Univ. of Western Australia and Univ. of Oxford 297. JOINT EVENT: COMMUNITY AND PUBLIC 4:45 295.8 Iron Status Predicts EEG Measures of Brain HEALTH AND, NUTRITION EDUCATION AND Function during a Memory Task in 4-6 Month Old Infants BEHAVIORAL SCIENCE RIS BUSINESS and May Reveal Associations between Early Iron Status MEETING AND SPEED NETWORKING SESSION and Memory Behavior. J.E.H. Nevins, S.S. Robertson, R.L. Canfield, J.D. Haas. Cornell Univ. RIS Forum 296. NUTRITION IMMUNOLOGY, INFECTION (Sponsored by: Nutrition Education and Behavioral AND INFLAMMATION Science RIS) (Cosponsored by: Community and Public Health Minisymposium Nutrition RIS)

(Sponsored by: Nutritional Immunology RIS) Mon. 3:00 pm—San Diego Convention Center, Room 28DE

Mon. 3:00 pm—San Diego Convention Center, Room 30D Chaired: A.R. Mobley Chaired: E.A. Karlsson Cochaired: S. Colby Cochaired: S. Comstock

3:00 296.1 Formula Diet-Driven Microbial Diversity and GLOBAL NURITION COUNCIL BUSINESS Immunological Consequence in Small Intestine of Neonatal MEETING AND KELLOGG PRIZE Porcine Model. V.L. Yeruva, N. Spencer, A.K. Bowlin, S.V. FOR INTERNATIONAL NUTRITION Chintapalli, K. Shankar, L. Hennings, M.A. Cleves, M. Saraf, RESEARCH LECTURE T.M. Badger, M.J. Ronis. Arkansas Children’s Nutr. Ctr. and

LSU, New Orleans. Mon. 6:30 pm—Hilton San Diego Bayfront, Indigo AE 3:15 296.2 Anemia and Iron Status Are Predictors of Gut Microbiome Composition and Metabolites in Infants M.E. Bentley. Univ. of North Carolina at Chapel Hill and Children in Rural Kenya. D. Paganini, T. Jaeggi, C. Cercamondi, P. Kujinga, D. Moretti, M. Zimmermann. ETH Zurich and Wageningen Univ., Netherlands. 3:30 296.3 Offspring Immune Development Is Dependent on the Amount and Form of Choline in the Maternal Diet during Suckling. E.D. Lewis, C. Richard, S. Goruk, N. Dellschaft, Are You Tweeting about J.M. Curtis, R.L. Jacobs, C.J. Field. Univ. of Alberta. 3:45 296.4 The Impact of Environmental Enteropathy and EB 2016? Systemic Inflammation on Infant Growth Failure. C. Naylor, M. Lu, J.A. Ma, A.M. Prentice, W.A. Petri. MRC Unit, The Gambia, Univ. of Virginia and London Sch. of Hyg. and Trop. Med. To Tweet use #expbio 4:00 296.5 Monounsaturated Fatty Acids Impede Inflammation Partially through Activation of AMPK. C.L. Lyons, Be sure to follow EB on O.F. Finucane, A.M. Murphy, A.A. Cooke, B. Viollet, P.M. Vieira, W. Oldham, B.B. Kahn, H.M. Roche. Conway Inst. of Facebook and Twitter. Biomolec. and Biomed. Res., Dublin, Inst. Cochin, INSERM, Paris, Beth Israel Deaconess Med. Ctr., Harvard Med. Sch. and Brigham and Women’s Hosp.

90 MONDAY PATHOLOGY Pathology

298. ASIP 2016 TOWN HALL MEETING 11:15 300.2 Nucleoside Reverse Transcriptase Inhibitors Attenuate Angiogenesis and Lymphangiogenesis by Impairing Special Session Receptor Tyrosine Kinases Signaling in Endothelial Cells. L. Song, X. Zhu, C. Qiu, L. Qin, S.A. Chow, L. Yu. Zhejiang Mon. 7:00 am—San Diego Convention Center, Room 5A Univ., China, Yale Univ. Sch. of Med., UCLA. Back By Popular Demand...The ASIP 2016 Town Hall Meeting! 301. ACVP SYMPOSIUM: ILLUMINATING Join us for breakfast on Monday, April 4, 2016 from 7:00 am until 8:00 am to discuss present and future ASIP benefits, PATHOBIOLOGY: IMAGING ACROSS SCALE opportunities available to our members to become more involved in the Society, and ideas for the future. The ASIP Town Hall Meeting Symposium is a chance for you to meet with ASIP’s Director of Membership, (Sponsored by: the ASIP Veterinary and Comparative Membership Committee Chair, and other ASIP Leadership and to Pathology Scientific Interest Group and the American express your thoughts, ideas, and opinions. Is there a member College of Veterinary Pathologists) benefit you would like for us to offer? Are you interested in working M Mon. 8:30 am—San Diego Convention Center, Room 5A more closely with the ASIP Leadership? Why not share your O comments and suggestions over a cup of coffee. Make plans now Chaired: R. Sullivan N to join the discussion…registration is NOT required! Cochaired: S. Fossey and R. Johnson

299. ASIP COTRAN EARLY CAREER INVESTIGATOR Imaging, Immunohistochemistry and Microscopy AWARD LECTURE Veterinary and Comparative Pathology

Award Lecture Breast Cancer

Mon. 8:30 am—San Diego Convention Center, Room 2 8:30 Multiscale Imaging of Cellular Microenvironments. K. Eliceiri. Univ. of Wisconsin-Madison. Metabolism and Metabolic Disease 9:05 Living Imaging of the Mouse Bone Marrow by Intravital Cell and Tissue Injury Microscopy. C. Lin. Harvard Univ. 9:40 In Vivo Metabolic Imaging to Discern Tumor and ASIP Cotran Early Career Investigator Award Lecture: Stromal Cells in the Breast Tumor Microenvironment. How Metabolism Regulates Retinal Function: J. Szulczewski. Univ. of Wisconsin-Madison. Implications for Prevention of Disease. M. Saint- 10:15 Manual Pathology Scoring – The Gold-Standard Geniez. Schepens Eye Research Inst. Paradox. F. Aeffner. Flagship Biosciences Inc., Westminster, CO. 300. BLOOD VESSEL CLUB™: ANGIOGENSIS IN 10:50 Translational Imaging Techniques. M. Rosol. Novartis AG. ORGAN DEVELOPMENT AND FUNCTION 302. SIPMET SYMPOSIUM: SEX STEROID Symposium HORMONES ACTION IN METABOLISM,

Mon. 8:30 am—San Diego Convention Center, Room 2 DIFFERENTIATION, AND DAMAGE RESPONSE

Chaired: D. Bielenberg Symposium

Cochaired: K. Moulton (Sponsored by: ASIP and the Società Italiana di Patologia e Medicina Traslazionale /Italian Society of Pathology Vascular Biology and Translational Medicine) 8:30 ASIP Cotran Early Career Investigator Mon. 8:30 am—San Diego Convention Center, Room 3 Award Lecture: How Metabolism Regulates Retinal Function: Implications for Prevention of Disease. M. Saint-Geniez. Chaired: A. Migliaccio Schepens Eye Research Inst. 9:30 Molecular Regulation of Vascular Permeability. Cochaired: A. Rogers C. Kuo. Stanford Univ. Sch. of Med. Metabolism and Metabolic Disease 10:15 Notch Signaling in Arteriovenous Differentiation and Disease. R. Wang. UCSF. Cell and Tissue Injury 11:00 300.1 Endothelial Follistatin-Like 1 Regulates the 8:30 New Insights into Estrogen Signaling. M. Baker. UCSD. Maturation of the Pulmonary Vasculature by Modulating BMP/ 9:15 Hormonal Regulation of Sex-Specific Liver Diseases. Smad Signaling. N.P. Tania, H. Maarsingh, S.T. Bos, A. Mattiotti, A. Rogers. Tufts Univ. S. Prakash, W. Timens, M. Schmidt, M. van den Hoff, R. Gosens. 10:00 Cross-Talk between Androgen Receptor and NGF Univ. of Groningen, Palm Beach Atlantic Univ., Academic Med. Receptor (Trka) in Neuronal Cells. A. Migliaccio. Ctr., Amsterdam and Univ. Med. Ctr. Groningen, Netherlands. State Univ. of Naples. 10:45 Androgen Signaling in Skeletal Muscle. D. Metzger. IGBMC, Illkirch, France.

91 PATHOLOGY MONDAY

303. STOWELL SYMPOSIUM/TRENDS IN 305. EPITHELIAL JUNCTIONS, CELL MIGRATION EXPERIMENTAL PATHOLOGY: THE AND TISSUE REPAIR SCIENCE OF HEALTH DISPARITIES: NEW PARADIGMS, APPROACHES AND IMPACT ON Minisymposium

DISEASE PREVENTION Mon. 2:00 pm—San Diego Convention Center, Room 3

Symposium Chaired: S. Colgan

Mon. 8:30 am—San Diego Convention Center, Room 4 Cochaired: V. Spindler

Chaired: K. Gardner Transporters/Channels/Barriers

Cochaired: C. Yates Cell and Tissue Injury

Metabolism and Metabolic Disease Epithelial and Mucosal Pathobiology 8:30 KEYNOTE LECTURE: What Creates Health Disparities? 2:00 305.1 Loss of Dsg2 Promotes Tumorigenesis in P. Braveman. UCSF. Pancreatic Cancer Cells through ERK Activation. K. Huetz, J. 9:15 Epigenetics in Cancer Health Disparities. C. Yates. Waschke, V. Spindler. Ludwig Maximilians Univ. Munich Tuskegee Univ. 2:15 305.2 Central Role for Intestinal Epithelial IL-10R1 10:00 Can Genome Sciences Help Increase Our Understanding Signaling in Barrier Restitution. J.M. Lanis, E.E. Alexeev, of the Role of Biology in Cancer Health Disparities? D.J. Kao, D.A. Kitzenberg, K.D. Schwisow, D.J. Kominsky, Towards Improvements in Clinical Management of S.P. Colgan. Univ. of Colorado Anschutz Med. Campus and Cancer Through Precision Medicine. J. Carpten. Montana State Univ. Translational Genomics Res. Inst., Phoenix. 2:30 305.3 Redundant Role of Catenins in Maintaining 10:45 Analysis of Tumor Biology to Advance Cancer Health Tight Junctional Integrity. T. Pradhan-Sundd, L. Zhou, A. Disparity Research. S. Ambs. NCI, NIH. Jiang, J.O. Russell, S. Singh, M. Poddar, S. Ranganathan, K. Nejak-Bowen, S. Singh Pal Monga. Univ. of Pittsburgh. 2:45 305.4 Keratin Filaments Regulate Binding Properties 304. ASIP PRESIDENTIAL SYMPOSIUM: of the Desmosomal Adhesion Molecule Desmoglein 3. MOLECULAR PATHOGENESIS OF TRIPLE- F. Vielmuth, F. Loschke, T.M. Magin, J. Waschke, V. Spindler. NEGATIVE BREAST CANCER: IMPLICATIONS Ludwig Maximilians Univ. Munich and Univ. of Leipzig. FOR PREVENTION AND THERAPY 3:00 305.5 Vesicle Fusion Protein, YKT6, Is a Novel Regulator of Epithelial Cell-Matrix Adhesion and Migration. Symposium A. Ivanov, N. Naydenov, S. Joshi, A. Feygin. Virginia (Supported by an unrestricted educational grant from Commonwealth Univ. Friends for an Earlier Breast Cancer Test) 3:15 305.6 Intestinal Epithelial Cell Expression of CD47 Facilitates Proliferation, Neutrophil Transmigration, and Wound (Sponsored by: earlier.org) Healing In Vivo. M. Reed, A-C. Luissint, A. Nusrat, C.A. Parkos. Univ. of Michigan. Mon. 2:00 pm—San Diego Convention Center, Room 2 3:30 305.7 The Specialized Pro-resolving Lipid Mediator Chaired: W.B. Coleman Resolvin E1 Promotes Intestinal Mucosal Wound Repair. M. Quiros, H. Nishio, G. Leoni, R. Agarwal, G. Bernal, C. Cancer Biology Gerner-Smith, C. Gerner-Smith, R. Colas, K. Graham, C. Neoplasia Serhan, A. Garcia, C. Parkos, A. Nusrat. Univ. of Michigan, Inst. for Cardiovasc. Prevent., Munich, Georgia Tech, Emory 2:00 Identification of Drivers of Triple-Negative Breast Cancer. Univ. and Harvard Univ. J. Reis-Filho. Mem. Sloan Kettering Cancer Ctr. 3:45 305.8 Cortactin Is Required to Maintain Intestinal 2:55 Target Discovery through Next-Gen Sequencing Epithelial Barrier Homeostasis. A.F. Citalán-Madrid, A. García- of Triple-Negative Breast Cancer. G. Tsongalis. Ponce, H. Vargas-Robles, A. Betanzos, P. Nava, K. Rottner, Dartmouth-Hitchcock Med. Ctr. R. Menningen, M. Schnoor. CINVESTAV-IPN, Mexico City, 3:50 Exploitation of Molecular Features to Personalize Tech Univ. Braunschweig and Univ. Hosp. Münster, Germany. Therapeutic Approaches in Triple-Negative Breast 4:00 305.9 Sympathetic Signaling Regulates Cancer. C. Anders. Univ. of North Carolina Lineberger Cardiomyocyte Cohesion via the Plaque Protein Plakoglobin. Comprehensive Cancer Ctr. C. Schinner, A. Schlipp, V. Rötzer, F. Vielmuth, A. Messoudi, A. Horn, V. Spindler, J. Waschke. Ludwig Maximilians Univ. Munich. 4:15 305.10 Role of Hypoxia-Inducible Factor on Colonic Goblet Cell Differentiation and Function during Mucosal Healing. A.K. Whitney, K.D. Schwisow, A.J. Bayless, L. Golden-Mason, G. Mehta, K.A. Kuhn, S.P. Colgan, E.L. Campbell. Univ. of Colorado Anschutz Med. Campus.

92 MONDAY PATHOLOGY

4:30 305.11 Transgenic Up-Regulation of Claudin-6 4:10 306.9 Prostaglandin E2 Inhibits Monocyte Decreases Diesel Particulate Matter-Induced Pulmonary Chemotactic Protein 5 Production and Secretion in Mouse Inflammation. J. Bodine, J. Gassman, D.C. Milner, A. Lewis, Cardiac Fibroblasts via EP4 Receptor. T.D. Bryson, D. T. Dunaway, K. Egbert, C. Christiansen, A. Christiansen, Szandzik, P. Harding. Henry Ford Hlth. Syst. and Wayne State T. Monson, D. Broberg, J. Arroyo, P.R. Reynolds. Brigham Univ. Sch. of Med. Young Univ. 4:45 305.12 Altered Inflammatory Responses in Tobacco 307. SUGAR, SUGAR, AWWW, HONEY, HONEY... Smoke-Exposed Mice That Over-Express the Tight Junctional PATHOPHYSIOLOGY OF DIABETES, OBESITY Protein Claudin-6. J.B. Lewis, J. Bodine, D. Milner, A. Lewis, AND METABOLIC COMPLICATIONS T. Dunaway, K. Egbert, S. Albright, B. Merrill, T. Monson, M. Watson, N. Burstedt, Q. Smith, J. Gassman, T. Jergensen, B. Minisymposium Chavarria, D. Broberg, D. Thomas, J. Arroyo, P.R. Reynolds. Brigham Young Univ. Mon. 2:00 pm—San Diego Convention Center, Room 4

Chaired: K. Lenhart 306. MECHANISMS OF MYOCARDIAL FAILURE AND FIBROSIS Cochaired: M.S. Willis Metabolism and Metabolic Disease M Minisymposium 2:00 Introduction. O Mon. 2:00 pm—San Diego Convention Center, Room 5A 2:05 307.1 High Glucose Culture Medium Downregulates N Chaired: J. Schisler Production of Human β-Defensin-2 in Human Amniotic Epithelial Cells. D. Szukiewicz, H. Alkhalayla, M. Pyzlak, G. Cochaired: T. Nevers Szewczyk. Med. Univ. of Warsaw. Cardiac Pathobiology 2:20 307.2 Insulin Signaling Regulation of Sortilin 1 and Glut4 Storage Vesicle Formation in NIH 3T3-L1 Adipocytes 2:00 Introduction. and Mouse Adipose Tissue. J. Li, D. Matye, Y. Wang, T. Li. 2:10 306.1 The Role of miR-378*, miR-218 and miR-351 Univ. of Kansas Med. Ctr. in Cardiac Hypertrophy. S. Sadiq, F.J. Charchar, T. Crowley, L. 2:35 307.3 Serum miRNAs as Potential Biomarkers for Delbridge, S. Harrap, P. Lewandowski. Sch. of Med., Deakin Early Prediction of Type 1 Diabetes. C. Yin, M. Weiland, J. Li, Univ., Federation Univ. and Univ. of Melbourne, Australia. R. She, L. Zhou, Q. Mi. Henry Ford Hlth. Syst. 2:25 306.2 Resolution Agonist 15-epi-Lipoxin A4 Directs 2:50 307.4 Insulin Treatment Increases Myocardial FPR2 to Expedite Healing Phase Post-myocardial Infarction. Ceramide Accumulation and Disrupts Cardiometabolic Function. V. Kain, F. Liu, V. Kozlovskaya, K.A. Ingle, S. Khedkar, S.D. A.E. Hodson, T.S. Tippetts, B.T. Bikman. Brigham Young Univ. Prabhu, E. Kharlampieva, G.V. Halade. Univ. of Alabama at 3:05 307.5 Mitochondrial Fission Is Necessary for Ceramide- Birmingham and Chembio Discovery Solutions, Boston. Induced Metabolic Disruption. B.T. Bikman. Brigham Young Univ. 2:40 306.3 Nebulized Delivery of the MAPKAP Kinase 2 3:20 307.6 Pancreatic Trypsin and Insulin Receptor Peptide Inhibitor MMI-0100 Protects against Ischemia-Induced Cleavage in High Fat Diet Rats. A.S. Courelli, R. Mazor, G.W. Systolic Dysfunction. D. Brown, B. Cooley, M. Quintana, C. Schmid-Schonbein. UCSD. Landers, M.S. Willis. Univ. of North Carolina at Chapel Hill and 3:35 307.7 Loss of CHIP Expression Perturbs Glucose Moerae Matrix, NJ. Homeostasis and Leads to Type II Diabetes through Defects 2:55 306.4 Activation of TRPVv1 by 12(S)-HpETE and in Microtubule Polymerization and Glucose Transporter 20-HETE Releases CGRP and Protects the Heart against the Localization. K.C. Lenhart, H. McDonough, S.M. Ronnebaum, Cardiac Dysfunction Caused by LPS. J. Chen, A.J.P. Hamers, J. An, C.B. Newgard, M.S. Willis, C. Patterson, J.C. Schisler. M. Finsterbusch, C. Thiemermann, A. Ahluwalia. Barts Univ. of North Carolina at Chapel Hill and Duke Univ. and The London Sch. of Med. and Dent., Queen Mary Univ. 3:50 307.8 The Role of the Duffy Antigen Receptor for of London. Chemokines in Metabolic Disease. T.W. Benson, T. Chatterjee, 3:10 306.5 Pharmacological Inhibition of p38/MAPK J. Joseph, O. Popoola, M. Crowe, N. Yiew, D. Unruh, D. Improves Cardiac Function in Cardiac-Specific Bag3-P209L Weintraub, A. Pillai, J. Williams, J. Mintz, B. Stansfield, D. Transgenic Mice. S.C. Eaton, S. Takayama, T.N. Sidorova, Stepp, J. Brittain, V. Bogdanov, N. Weintraub. Med. Col. of K.T. Murray, M.S. Willis. Univ. of North Carolina at Chapel Hill, Georgia at Augusta Univ. and Univ. of Cincinnati. Boston Univ. and Vanderbilt Univ. 4:05 307.9 Augmented Adipocyte Browning and 3:25 306.6 Intercellular Adhesion Molecule 1 Regulates Mitochondrial Function in Periadrenal Fat but Not Subcutaneous Left Ventricular Leukocyte Recruitment, Cardiac Remodeling Fat in Pheochromocytoma Patients. G.R. Davies, L. Vergnes, and Function in Pressure Overload-Induced Heart Failure. M. Yeh, A. Harari, M. Livhits, J. Huang, M. Symonds, K. A.M. Salvador, T. Nevers, M. Aronovitz, B. Wang, I. Jaffe, R. Reue, H. Sacks. Univ. of Nottingham, UCLA and VA Greater Blanton, P. Alcaide. Tufts Med. Ctr. Los Angeles Healthcare. 3:40 306.7 Th1 Effector T Cells Induce Cardiac Fibroblasts 4:20 307.10 Inhibition of Adipocyte and Preadipocyte Transition to Myofibroblasts and Contribute to Pressure Fusion Reduces Abdominal Adipose Tissue Mass in Obese Overload-Induced Cardiac Fibrosis. T. Nevers, A.M. Salvador, Mice. X. Yuan, X. Xu, N. Li, W.L. Dewey, P-L. Li, F. Zhang. F. Velazquez, M. Aronovitz, R. Blanton, P. Alcaide. Tufts Med. Col. of Virginia, VCU. Med. Ctr. and Tufts Univ. 4:35 Discussion. 3:55 306.8 Fenofibrate Induces Cardiac Fibrosis in Mice Lacking the Co-chaperone and E3-Ubiquitin Ligase CHIP. S. Ravi, M.S. Willis, P. Lockyer, C. Patterson, J.C. Schisler. Univ. of North Carolina at Chapel Hill. 93 PATHOLOGY/PHARMACOLOGY MONDAY

308. ASIP MEMBERSHIP BUSINESS MEETING AND 309. ASIP AWARDS RECEPTION AWARDS PRESENTATION Special Session Business Meeting Mon. 6:30 pm—San Diego Convention Center, Room Mon. 5:00 pm—San Diego Convention Center, Room 2 6A Foyer

Pharmacology

310. JOHN J. ABEL AWARD IN 312. WNT SIGNALING: FROM PHARMACOLOGY LECTURE DISEASE MECHANISMS TO THERAPEUTIC INTERVENTIONS Award Lecture Symposium Mon. 8:30 am—San Diego Convention Center, Room 16AB (Sponsored by: The Division for Molecular Pharmacology) The John J. Abel Award in Pharmacology, named after the founder of ASPET, was established in 1946 to stimulate (Cosponsored by: The Divisions for Cardiovascular fundamental research in pharmacology and experimental Pharmacology, Cancer Pharmacology, Translational therapeutics by young investigators. and Clinical Pharmacology, and Drug Discovery and Development ) 8:30 Introduction. 8:35 Epithelial-Mesenchymal Plasticity in Carcinoma Mon. 9:30 am—San Diego Convention Center, Room 17B Metastasis. J. Yang. UCSD. Cochaired: R. Gosens and W.M. Blankesteijn

311. HEAR IT FROM THE EDITORS: NAVIGATING THE Molecular Pharmacology COURSE THROUGH JOURNAL SUBMISSION Cancer Biology AND PUBLICATION Regenerative Medicine (Stem Cells, Tissue Symposium Regeneration, Biomaterials) (Cosponsored by: All ASPET Divisions) 9:30 Evolution of Wnt Signaling: From Developmental Biology Towards Therapeutic Application. W.M. Blankesteijn. Mon. 9:30 am—San Diego Convention Center, Room 16AB Cardiovasc. Res. Inst. Maastricht. Cochaired: M. Vore and E.T. Morgan 9:40 Receptor-Ligand Selectivity of Wnt/Frizzled Signaling. G. Schulte. Karolinska Inst. Career Development 10:05 Wnt Signal Pathways in Stem Cells and 9:30 How to Choose a Journal for Your Manuscript? M. Vore. Cancer. X. He. Boston Children’s Hosp. Univ. of Kentucky. 10:30 Wnt Signaling in Respiratory Diseases. M. Königshoff. 9:50 How to Write a Competitive Manuscript. M. Jarvis. CPC Großhadern, Germany. AbbVie, Inc. 10:55 Targeting Wnt Signaling in Cardiovascular Diseases. 10:10 Communicating Experimental Design and Analysis A. Deb. UCLA. Considerations. E.T. Morgan. Emory Univ. 11:20 Tankyrases Are Druggable Targets for the Treatment of 10:30 The Peer-Review Process: Rejection, Revision, and Metabolic Disorders. O. Obianom, W. Yang, F. Xue, Y. Acceptance. S. Traynelis. Emory Univ. Shu. Univ. of Maryland Baltimore. (1189.5) 10:50 Authorship, Accountability and Ethics. R. 11:33 A Novel Activator of Canonical Wnt Signaling. J. Baruah, Dodenhoff. ASPET. K.K. Wary, R. Hitzman, J. Zhang. Univ. of Illinois at 11:10 Panel Discussion. Moderator: D. Sibley. ASPET Board Chicago. (931.14) of Publications Trustees. 11:46 Structure-Activity Relationship of Peptide Inhibitors of the Wnt/Frizzled Interaction. W.M. Blankesteijn, K.C.M. Hermans, A.I. Fernandez-Llamazares, N. Kriek, P. Timmerman. Maastricht Univ. and Pepscan Therapeut. Netherlands. (931.13)

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94 MONDAY PHARMACOLOGY

313. SUBSTRATE MODULATION OF ORGANIC 315. PHARMACOMETABOLOMICS ENABLING ANION AND CATION TRANSPORTERS TOOLS FOR SYSTEMS PHARMACOLOGY AND PRECISION MEDICINE Symposium Symposium (Sponsored by: The Division for Drug Metabolism) (Sponsored by: The Division for Translational and (Cosponsored by: The Division for Clinical Pharmacology) Molecular Pharmacology) (Cosponsored by: The Divisions for Molecular Mon. 9:30 am—San Diego Convention Center, Room 15A Pharmacology and Cardiovascular Pharmacology ) Cochaired: B. Hagenbuch and J. Lampe Mon. 9:30 am—San Diego Convention Center, Room 17A Drug Metabolism Cochaired: R. Kaddurah-Daouk and R. Weinshilboum Transporters/Channels/Barriers Translational and Clinical Pharmacology 9:30 Introduction. Microbiome 9:40 Substrate and Inhibitor Modulation of Hepatic OCT1 Transport. J. Lampe. Univ. of Kansas Med. Ctr. 9:30 Pharmacometabolomics Enabling Tools for Systems M 10:10 Substrate-Dependent Ligand Interaction with MATE Pharmacology and Precision Medicine. R. Kaddurah- O Transporters. S. Wright. Univ. of Arizona. Daouk. Duke Univ. Med. Ctr. N 10:40 Substrate-Dependent Modulation of OATP1B1 and 10:00 Pharmacometabolomics Informs and Compliments OATP1B3. B. Hagenbuch. Univ. of Kansas Med. Ctr. Pharmacogenomics. R. Weinshilboum. Mayo Clin. 11:10 Substrate Modulation of Drug Transporters: An Industry 10:30 Gut Microbiome and Host Metabolic Interactions – Perspective. C. Lee. Ardea Biosciences. Implications for Drug Metabolism and Drug-Induced 11:40 Organic Cation Transporters in Drug Interactions with Toxicity. W. Jia. Univ. of Hawaii Cancer Ctr. Methamphetamine and Metabolites. D.J. Wagner, J. 11:00 Integrating Multiple Omics Reveals Novel Signatures Wang. Univ. of Washington. (935.6) Associated with Thiazide Diuretics Blood Pressure Response. M. Shahin. Univ. of Florida. 314. A PHARMACOKINETICS PRIMER: FROM 11:20 Stable Isotope Resolved Metabolomics on Fresh Human EQUATIONS TO APPLICATION Tissues as a Preclinical Drug Testing Platform. A.N. Lane. Univ. of Kentucky. Symposium 11:50 Question and Answer Period.

(Sponsored by: The Division for Pharmacology Education) 316. BEYOND TRADITIONAL ASSESSMENTS OF (Cosponsored by: The Divisions for Molecular PAIN: IMPLICATIONS FOR DRUG DISCOVERY Pharmacology, Drug Discovery and Development, OF NOVEL PAIN THERAPEUTICS Drug Metabolism, Cardiovascular Pharmacology, and Translational and Clinical Pharmacology ) Symposium Mon. 9:30 am—San Diego Convention Center, Room 14B (Sponsored by: The Division for Behavioral Pharmacology) Chaired: R. Mehvar (Cosponsored by: The Divisions for Neuropharmacology, Pharmacology Education and Drug Discovery and Development ) Education Mon. 9:30 am—San Diego Convention Center, Room 15B This conceptual, less-mathematical pharmacokinetics Cochaired: C.A. Paronis and H. Neelakantan primer is designed for a general audience with a background in Pharmacology or Biomedical Sciences, who use or plan Behavioral Pharmacology to use pharmacokinetics in their research or as part of their instructional responsibilities. In part one, designed for both Neurobiology researchers and educators, fundamental concepts behind the 9:30 Analgesic Medication Development: Finding the major pharmacokinetic parameters, including their estimation Appropriate Assay to Identify New Therapeutics. and application will be discussed. Part two will be a more hands- R.P. Yezierski. Univ. of Florida. on session, utilizing simulations and other exercises, which will 10:00 Novel Methods of Assessing Nociception and be more useful to pharmacology educators. Seating at hands- Antinocieption in Nonhuman Primates. B. Kangas. on tables is on a first-come basis. Harvard Med. Sch., McLean Hosp. 9:30 Fundamental Concepts in Pharmacokinetics: 10:30 Pharmacological Responses in Spontaneous Pain. Applications in Research and Education. R. Mehvar. J. Mogil. McGill Univ. Chapman Univ. 11:00 Depression of Home Cage Wheel Running: A Novel 11:00 Active Learning Exercises in Pharmacokinetics Using Method to Assess Spontaneous Migraine Pain. Simulations and Other Resources. D. Brocks, R. R. Kandasamy, J.J. Calsbeek, M.M. Morgan. Mehvar. Univ. of Alberta and Chapman Univ. Washington State Univ. (928.4) 11:15 Distinguishing Nonopioid Mediators of Pain Responses. A. Hohmann. Indiana Univ.

95 PHARMACOLOGY MONDAY

11:45 Neuropathic Pain Unmasks Delta Opioid Receptor- 319. DIVERSITY 3.0: FROM FAIRNESS Mediated Analgesia. E.W. Ong, S.V. Holdridge, TO EXCELLENCE K.A. Sutherland, S.A. Armstrong, A.M.W. Taylor, L. Xue, C.M. Cahill. Queen’s Univ., Canada, Univ. of Lecture California, Irvine and UCLA. (928.1) (Sponsored by: The ASPET Mentoring and Career Development Committee) 317. BERNARD B. BRODIE AWARD IN DRUG METABOLISM LECTURE Mon. 2:00 pm—San Diego Convention Center, Room 17B Education Award Lecture Career Development (Sponsored by: The Division for Drug Metabolism) This talk will describe the needed evolution from thinking Mon. 2:00 pm—San Diego Convention Center, Room 15A about diversity as competing with excellence to being a core Drug Metabolism driver and marker of excellence. Through vivid narrative and illustrative examples from other industries, be prepared and open The Bernard B. Brodie Award in Drug Metabolism has been to a new vision on how we harness diversity and its necessary established to honor the fundamental contributions of Bernard B. inclusion to advance our profession. Participants from all EB Brodie in the field of drug metabolism and disposition. The Award disciplines are welcome. is presented biennially to recognize outstanding original research contributions in drug metabolism and disposition, particularly 2:00 Diversity 3.0: From Fairness to Excellence. M.A. Nivet. those having a major impact on future research in the field. Assn. of Amer. Med. Cols. 2:00 Introduction. 2:05 Phenobarbital Induction of Drug Metabolism and 320. NOVEL PLATELET THERAPIES: ATTACKING Beyond. M. Negishi. NIEHS, NIH. THEM FROM THE INSIDE AND OUT

Symposium 318. P.B. DEWS LIFETIME ACHIEVEMENT AWARD FOR RESEARCH IN BEHAVIORAL (Sponsored by: The Division for Cardiovascular Pharmacology) PHARMACOLOGY LECTURE (Cosponsored by: The Division for Translational and Clinical Pharmacology) Award Lecture 3:00 pm—San Diego Convention Center, Room 16AB (Sponsored by: The Division for Behavioral Pharmacology) Chaired: M. Nieman

Mon. 2:00 pm—San Diego Convention Center, Room 15B Cardiovascular Pharmacology Behavioral Pharmacology 3:00 The Neighborhood Matters: How Interactions Within the Membrane Influence Therapeutic Response. The ASPET Division for Behavioral Pharmacology sponsors M. Nieman. Case Western Reserve Univ. the P. B. Dews Award for Research in Behavioral Pharmacology 3:30 Characterization of Function Blocking Antibodies to recognize outstanding lifetime achievements in research, Targeting Platelets. Z. Karim. Western Univ. of teaching, and professional service in the field of behavioral Hlth. Scis. pharmacology and to honor Dr. Peter Dews for his seminal 4:00 Targeting G-protein Coupled Receptors from the Inside contributions to the development of behavioral pharmacology as with Small Molecules. R. Flaumenhaft. Beth Israel a discipline. Deaconess Med. Ctr. 2:00 Introduction. 4:30 Platelet-Inspired Synthetic Hemostats: Mimicking 2:05 Behavioral Mechanisms of Drug Action: Peter Dews’s Platelet Functions on Engineered Biomaterial Legacy. T. Thompson. Univ. of Minnesota. Systems to Treat Bleeding. A.S. Gupta. Case Western Reserve Univ. 5:00 Nanogel Drug Carriers Presenting Platelet GPIbα Mimic and Enhance Platelet Adhesion. J.W. Myerson, I. Johnston, J. Wu, R. McClintock, Z. Ruggeri, M. Poncz, V. Muzykantov. Univ. of Pennsylvania and Are You Tweeting about The Scripps Res. Inst. (943.2) 5:15 Loss of Serotonin Transporter Function Alters ADP- EB 2016? Mediated αIIbβ3 Activation through Disregulation

of 5HT2A Receptor. K.H. Oliver, H. Hamm, A.M.D. To Tweet use #expbio Carneiro. Vanderbilt Univ. (943.10)

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96 MONDAY PHARMACOLOGY

321. DIVISION FOR BEHAVIORAL PHARMACOLOGY 3:45 SULT4A1 Deletion in Zebrafish Alters Expression of SYMPOSIUM: QUANTITATIVE Genes Implicated in Neurological Disorders. P.L. PHARMACOLOGICAL ANALYSIS OF IN Garcia, F.L. Crittenden, C.N. Falany. Univ. of VIVO DATA AND ITS IMPLICATIONS IN CNS Alabama at Birmingham. (1196.4) 4:00 Induction of CYP2A6 by Metronidazole in Primary DRUG DISCOVERY Human Hepatocytes. S. Stancil, C. Vyhlidal, G. Kearns, S. Leeder, R.E. Pearce. Children’s Mercy Division Symposium Hosp. and Univ. of Missouri-Kansas City and Arkansas (Sponsored by: The Division for Behavioral Pharmacology) Children’s Hosp. Res. Inst., Little Rock. (934.9) 4:15 Endogenous Substrates for Tumor-Specific Human Mon. 3:00 pm—San Diego Convention Center, Room 15B Cytochrome P450 CYP2W1. Y. Zhao, P. Ortiz de Cochaired: J-X. Li and L. Gerak Montellano. UCSF. (934.7) 4:30 Dose of Phenobarbital and Age of Treatment at Early Behavioral Pharmacology Life are Two Key Factors for the Persistent Induction of Cytochrome P450 Enzymes in Adult Mouse Liver. 3:00 Understanding the Actions of GABAA Receptor Modulators In Vivo Using Schild Analyses in Rhesus Y. Chen Tien. Univ. of Connecticut Sch. of Pharm. 5:00 Modulation of P-Glycoprotein at the Human Blood- Monkeys. L. Gerak. Univ. of Texas Hlth. Sci. Ctr. at M San Antonio. Brain Barrier by Quinidine or Rifampin Treatment: A 3:30 Comparison of Heroin- and Δ9-Tetrahydrocannabinol- Positron Emission Tomography Imaging Study. L. Liu. O Induced Antinociception and Physical Dependence Merck, Inc. N in Monkeys. H. Ding, N. Kiguchi, S. Kishioka, M-C. Ko. Wake Forest Sch. of Med. and Wakayama Med. 323. DIVISION FOR MOLECULAR PHARMACOLOGY Univ., Japan. (703.5) POSTDOCTORAL SCIENTIST 4:00 Combining Imidazoline I2 Receptor Ligands and Opioids AWARD FINALISTS for Pain Management: A Composite Additive Curve Analysis. J. Li. Univ. at Buffalo. Division Oral Session 4:30 Predicting Additivity: Abuse-Related Effects of “Bath- Salt” Mixtures. G. Collins. South Texas Veterans (Sponsored by: The Division for Molecular Pharmacology) Hlth. Care Syst. - Audie L. Murphy VA Hosp. Mon. 3:00 pm—San Diego Convention Center, Room 17B 5:00 PK/PD Modeling of Opioid Modulation: Application in the Development of a Novel Treatment for Depression. Molecular Pharmacology R. Turncliff. Alkermes, Inc. 3:00 β-Adrenergic Receptors Regulate Innate Immune Responses through β-Arrestin Dependent Pathways. 322. DIVISION FOR DRUG METABOLISM JAMES L.A. Grisanti, J. Gorsky, A.A. Repas, E. Gao, R.L. GILLETTE AWARD AND PLATFORM SESSION Carter, J.E. Rabinowitz, J.L. Benovic, W.J. Koch, D.G. Tilley. Temple Univ. Sch. of Med. (1202.6) Division Oral Session 3:30 Structural and Functional Characterization of the Metastatic RhoGEF P-Rex1 and Its Regulation by (Sponsored by: The Division for Drug Metabolism) PtdIns(3,4,5)P3: Towards Inhibitory Small Molecule Mon. 3:00 pm—San Diego Convention Center, Room 15A Development. J.N. Cash, E.M. Davis, J.J.G. Tesmer. Univ. of Michigan. (1190.5) Cochaired: E.E. Scott and T.J. Carlson 4:00 Structurally Diverse Positive Allosteric Modulators of Drug Metabolism the D1 Dopamine Receptor Potentiate G-Protein and β-Arrestin-Mediated Signaling. K.D. Luderman, J.L. 3:00 Predicting Fetal Exposure to Drugs throughout Conroy, R.B. Free, N.T. Southall, M. Ferrer, J. Aubé, Pregnancy Using a PBPK Model. Z. Zhang, M.Z. K.J. Frankowski, D.R. Sibley. NINDS, NIH, NCATS, Imperial, G.I. Patilea-Vrana, J. Wedagedera, G. Lu, NIH, Rockville and Univ. of North Carolina at Chapel J.D. Unadkat. Univ. of Washington and Simcyp Ltd (a Hill. (931.9) Certara Co.), Sheffield, U.K. (712.6) 4:30 Keynote Speaker. Signaling by G Proteins and 3:15 Implications of In Vitro System Conditions for CYP2C9 Phospholipase C: Yes it’s still exciting!! A.V. Smrcka. and CYP3A4: Impact of pH on Clearance and Univ. of Rochester Sch. of Med. and Dentistry. Enzyme Inhibition. L.R.A. Rougee, M.A. Mohutsky, D.W. Bedwell, K.J. Ruterbories, S.D. Hall. Eli Lilly and Co. (934.8) 3:30 Effect of Ethanol on the Metabolism of Antiretroviral Drugs Elvitegravir and Darunavir in the Presence and Absence of Their Pharmacoenhancers in Microsomes. N.M. Midde, M.A. Rahman, C. Rathi, J. Li, B. Meibohm, W. Li, S. Kumar. Univ. of Tennessee Hlth. Sci. Ctr., Memphis and East China Univ. of Sci. and Technol., Shanghai. (934.4)

97 PHARMACOLOGY MONDAY

324. DIVISION FOR TRANSLATIONAL AND CLINICAL 4:15 Preclinical Evaluation of Flt3 Ligand to Improve T Cell PHARMACOLOGY: YOUNG INVESTIGATOR Adaptive Immune Response during Sepsis. N.K. Patil, AWARDS PLATFORM SESSION J.K. Bohannon, L. Luan, Y. Guo, E.R. Sherwood. Vanderbilt Univ. Med. Ctr. (1202.3) Division Oral Session 4:35 Microbiota-Derived Metabolites Associated with Metabolic Improvements after Gastric Bypass (Sponsored by: The Division for Translational and Surgery and Their Effects on Intestinal Cells In Vitro. Clinical Pharmacology) M. Jennis, J.R. Mabus, C.R. Cavanaugh, G. Leo, J. Lenhard, P.J. Hornby. Janssen, Spring House, Mon. 3:00 pm—San Diego Convention Center, Room 17A PA. (720.3) Chaired: B.T. Green 4:55 Awards. Translational and Clinical Pharmacology 325. DIVISION FOR TRANSLATIONAL AND 3:00 Introduction. B.T. Green. USDA, ARS. CLINICAL PHARMACOLOGY: EARLY CAREER 3:15 Immunogenetic Role of G Protein Signaling Modulator 3 FACULTY SHOWCASE in the Pathogenesis of Rheumatoid Arthritis. B.J. Gall, A.B. Schroer, J.D. Gross, P. Stoilov, V. Setola, C.M. Division Oral Session Watkins, D.P. Siderovski. West Virginia Univ. Hlth. Sci. Ctr., Sch. of Med. (1202.5) (Sponsored by: The Division for Translational and 3:35 Systems Pharmacology Approach to Identify Potential Clinical Pharmacology) Therapeutic Small-Molecules for Treatment of Mon. 5:30 pm—San Diego Convention Center, Room 17A Diabetic Peripheral Neuropathy. B.A. McGregor, J.A. Porter, E.A. Feldman, J. Hur. Univ. of North Dakota Translational and Clinical Pharmacology and Univ. of Michigan. (1270.1) 5:30 Structure-Based Ligand Discovery for Nutrient 3:55 Doxorubicin Acutely Inhibits Lymph Flow in Rat Transporters. A. Schlessinger. Icahn Sch. of Med. at Mesenteric Lymph Vessels. A.J. Stolarz, T.W. Mount Sinai. (LB486) Fletcher, J.C. Marecki, M. Sarimollaoglu, E. 5:45 Novel Mechanisms Regulating Platelet and Pancreatic Galanzha, V. Zharov, S. Klimberg, N.J. Rusch. Univ. Beta Cell Function in Type 2 Diabetes Mellitus. of Arkansas for Med. Sci. (1201.2) J. Wisinski, A. Reuter, M. Kimple. Univ. of Wisconsin- Madison. (1270.7)

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98 MONDAY PHYSIOLOGY Physiology

326. APS PRESIDENT’S SYMPOSIUM SERIES 328. CARL LUDWIG DISTINGUISHED LECTURESHIP PHYSIOLOGICAL MECHANISMS OF THE APS NEURAL CONTROL AND RESPONSIVE TO BEHAVIORAL AND AUTONOMIC REGULATION SECTION ENVIRONMENTAL CHALLENGES Lecture DIETARY INFLUENCES ON PHYSIOLOGICAL CONTROL MECHANISMS — HOW MUCH, WHEN Mon. 8:00 am—San Diego Convention Center, Room 24 AND WHAT Neurobiology

Symposium Hypertension Neurophysiology Mon. 10:30 am—San Diego Convention Center, Ballroom 20A Neurogenic Hypertension and the Secrets of Respiration. B. Machado. Sch. of Med. Ribeirao Preto-USP, Brazil. Chaired: J. Anthony M Metabolism and Metabolic Disease 328A. RESPIRATORY-SYMPATHETIC COUPLING IN O Diet, Nutrition and Metabolism, and Development CARDIOVASCULAR DYSFUNCTIONS N

10:30 Amino Acid Deprivation and Nutritional Stress. Minisymposium T. Anthony. Rutgers, The State Univ. of New Jersey. 11:00 Cardiovascular, Renal and Metabolic Consequences Mon. 9:00 am—San Diego Convention Center, Room 24 of High Salt Diets. A. McDonough. Keck Sch. of Chaired: B.H. Machado Med., USC. 11:30 Metabolic Consequences of High Fructose Diet. 9:00 Are C1 Neurons Involved in the Sympathetic R. Johnson. Univ. of Colorado Denver. Overactivity Induced by Chronic Intermittent Hypoxia? 12:00 Timing of Meals: When Is as Critical as What and How D.J.A. Moraes, L.G.H. Bonagamba, J.F.R. Paton, Much. F. Turek. Northwestern Univ. B.H. Machado. Sch. of Med. of Ribeirão Preto, Univ. of São Paulo and Sch. of Physiol. and Pharmacol., 327. ACHIEVING MASTERY USING NON- Univ. of Bristol, U.K. (1006.9) STANDARDIZED ASSESSMENT METHODS 9:15 Increased Respiratory-Sympathetic Coupling via C1 Neurons Contributes to the Development of Featured Topic Hypertension in the Spontaneously Hypertensive Rat. C. Menuet, N. Jancovski, J.K. Bassi, A.A. Connelly, (Sponsored by: APS Teaching of Physiology Section) A.M. Allen. The Univ. of Melbourne (1006.8) 9:30 Enhanced Carotid Body Chemoreflex Function Drives Mon. 8:00 am—San Diego Convention Center, Room 25B Respiratorysympathetic Coupling in Systolic Heart Chaired: L. Golden Failure. R. Del Rio, N.J. Marcus, H.D. Schultz. Univ. Autónoma de Chile, Santiago, Des Moines Univ. and Education Univ. of Nebraska Med. Ctr. (LB725) 8:00 Collaborative Testing Improves Performance on 9:45 Active expiration and sympathetic excitation during Long Answer Questions, and Maintains Long- hypercapnia require glutamatergic neurotransmission Term Retention of Course Material. K.L. Ritchie, in the retrotrapezoid nucleus. E.V. Lemes and D.B. R. Rajakaruna, G. Newton. Univ. of Guelph, Zoccal. Department of Physiology and Pathology, Canada. (776.7) Sch. of Dent. of Araraquara, São Paulo State Univ., 8:20 Promoting Motivationally and Educationally Productive Araraquara, SP, Brazil. (757.7) Behaviors with Collaborative Testing. R.N. Cortright, H. Lujan, L.A. Johnson, S.E. DiCarlo. East Carolina Univ. and Wayne State Univ. (776.6) 8:40 Developing Online Guided Self-Assessments in Cardiovascular Physiology for Medical School. T.A. Pressley, J.C. Fowler. Texas Tech Univ. Hlth. Sci. Ctr. (776.20) 9:00 Discussion. 9:10 Undergraduate Collaborative Writing in STEM: How Learning to Write Authentically in the Discipline Can Promote Mastery. E.M. Waters, W.M. Schlegel. Indiana Univ. Bloomington. (553.1) 9:30 In Final Examinations, Quality of Essay Plan Correlates with the Essay Mark. P. Langton. Sch. of Physiol., Pharmacol. and Neurosci., Univ. of Bristol, U.K. (776.5) 9:50 Discussion.

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329. CEREBROVASCULAR DYSFUNCTION AND 330. COOPERATION BETWEEN REACTIVE NITROGEN SPECIES ADAPTIVE AND INNATE IMMUNITY IN CARDIOVASCULAR DISEASE Featured Topic Featured Topic (Sponsored by: APS Cardiovascular Section) (Sponsored by: APS Cardiovascular Section) Mon. 8:00 am—San Diego Convention Center, Room 28A Mon. 8:00 am—San Diego Convention Center, Room 27 Chaired: P. Katakam and J. Pollock Chaired: K. DeLeon-Pennell and L. de Castro Bras Oxidative Stress Myocardial Infarction/Heart Failure Neurobiology Inflammation/Immunity Neurophysiology 8:00 Inhibition of Neutrophil Chemotaxis by N-Acetyl- 8:00 Role of Peroxynitrite in Vasoconstriction of Brain Seryl-Aspartyl-Lysyl-Proline and Thymosin 4. Parenchymal Arterioles during Postischemic β P. Nakagawa, J. Xu, G. Bordcoch, B. Janic, O.A. Reperfusion. M. Cipolla. Univ. of Vermont. Carretero. Henry Ford Hosp. (1207.5) 8:30 Peroxynitrite-Mediated Impairment of Cerebrovascular 8:15 T Cell Deletion of Serum and Glucocorticoid-Regulated Function and Neovascularization in Diabetes. Kinase 1 Attenuates Hypertension and End-Organ A. Ergul. Medical Col. of Georgia. Inflammation. A.E. Norlander, M. Saleh, A. Pandey, 9:00 Critical Role of Telomerase in Regulating Cerebral H. Itani, J. Wu, B. Dale, D.G. Harrison, M. Madhur. Vascular Function and Redox Environment. K. Ait- Vanderbilt Univ. (1216.6) Aissa, J. Hockenberry, D.D. Gutterman, A. Geurts, 8:30 Role of Lymphocytes after Myocardial infarction. A.M. Beyer. Med. Col. of Wisconsin. (953.5) S. Frantz. Univ. Hosp. Wurzburg, Germany. 9:15 Role of Cerebrovascular Endothelial Dysfunction and 9:00 Non-resolving Chemokine Response Dysregulates Oxidative/Nitrative Stress in Impaired Functional Cardiosplenic and Cardiorenal Network following Hyperemia: Implications for Age-Related Vascular Myocardial Infarction in Aging. G.V. Halade, V. Kain, Cognitive Impairment. S. Tarantini, P.J. Toth, A. K. Ingle, L.M. Black. Univ. of Alabama at Birmingham. Davila, M.N. Valcarcel-Ares, Z. Tucsek, B. Varamini, (1208.1) P. Ballabh, W.E. Sonntag, J.A. Baur, A. Csiszar, Z. 9:15 Regulation of the Inflammatory Response in Cardiac Ungvari. Univ. of Oklahoma Hlth. Sci. Ctr., Univ. of Repair. N. Frangogiannis. Albert Einstein Coll. Pecs, Hungary, Univ. of Pennsylvania, Biola Univ. and of Medicine. New York Med. Col. (953.1) 9:45 Activated Immune Cells Exacerbate Angiotensin II- 9:30 Impaired Myogenic Response of MCA Elevates Induced Hypertension and Renal Damage in the Dahl Transmission of Pressure to Penetrating Arterioles Salt-Sensitive Rat. B.M. Wade, D. Mattson. Med. Col. and Contributes to Cerebral Vascular Disease in Aging of Wisconsin. (964.3) Hypertensive FHH Rats. F. Fan, M. Pabbidi, R.C.S. Lin, Y. Ge, E.P. Gomez-Sanchez, G.K. Rajkowska, M. Moulana, E. Gonzalez-fernandez, J. Sims, M.R. 331. HYPERTENSION: DEVELOPING CONCEPTS Elliott, I.A. Paul, A.P. Alexander, T.H. Mosley, D.R. Harder, R.J. Roman. Univ. of Mississippi Med. Ctr. Featured Topic and Med. Col. of Wisconsin. (953.7) (Sponsored by: APS Water and Electrolyte 9:45 Novel Splice Variant of nNOS in Cerebrovascular Homeostasis Section) Endothelial Cells Contributes to Superoxide and Peroxynitrite Generation. V.N. Sure, I. Merdzo, Mon. 8:00 am—San Diego Convention Center, Room 25C V.M. Abraham, N.P. Jain, G. Unis, T.P. Baker, N.R. Chaired: P. O’Connor and D. Ho Peterson, A.O. Gordon, A.L. Chen, I. Rutkai, D.W. Busija, P.V.G. Katakam. Tulane Univ. Sch. of Med. 8:00 The Role of Renal Pericytes in the Physiological and (953.3) Pathophysiological Regulation of Medullary Blood Flow. C. Peppiatt-Wildman. Medway Sch. of Pharmacy, Univ. of Kent and Greenwich. 8:30 RhoBTB1, a Novel PPARγ Target Gene Regulates Vascular Function. M. Mukohda, S-R.C. Ibeawuchi, C. Hu, F.W. Quelle, C.D. Sigmund. Univ. of Iowa and California Inst. for Biomed. Res., La Jolla. (964.14) 8:45 ACE2 Deletion Is Associated with Increased ADAM17 and Reduced Inhibitory Currents to Pre-sympathetic Hypothalamic Neurons. S. Mukerjee, J. Xu, S. Sriramula, H. Gao, A. Zsombok, E. Lazartigues. LSU Hlth. Sci. Ctr., New Orleans and Tulane Univ. (964.16)

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9:00 Leptin-Mediated Increases in Sympathetic Tone 333. METABOLIC CONSEQUENCES OF EXERCISE Decreases Alpha(1D)-Adrenergic Receptor Expression in Arteries and Adrenals. M. Newell, M. Featured Topic Momtahan, S. Kennard, E.J. Belin de Chantemele Med. Col. of Georgia at Augusta Univ. (964.15) (Sponsored by: APS Endocrinology and 9:15 Endothelial-Derived ET-1 Contributes to the Pressor Metabolism Section) Response Elicited by Acute Behavioral Stress. Mon. 8:00 am—San Diego Convention Center, Room 23 B.M. Fox, A.S. Loria, K.A. Hyndman, R. Johns, C. Jin, D.M. Pollock, M. Yanagisawa, J.S. Pollock. Chaired: J. Steiner and G.L.C. Yosten Univ. of Alabama at Birmingham, Univ. of Kentucky, Skeletal Muscle Physiology Georgia Regents Univ. and Univ. of Tsukuba, Japan. (964.10) Diabetes, Metabolic Syndrome 9:30 The Role of G i Proteins in the Regulation of PVN α 2 8:00 Exercise Potentiates Metabolic Adaptations through Neuronal Activation in Response to Isotonic Volume Autophagy Activation. A. Vainshtein. York Univ. Expansion in Conscious Rats. C.Y. Carmichael, N.M. 8:30 Impact of Specific Exercise Training Programs on Patel, R.E. Wipfler, R.D. Wainford. Boston Univ. Sch. Muscle Mitochondrial Biology in Aging and in Insulin of Med. (964.13) Resistant States. K. Sreekumaran Nair. Mayo Clin. 9:45 Hemodynamic Mechanisms of Renal Injury in Dahl M 9:00 HIF-1α Regulates a Single Bout of Exercise-Induced O SS Rats Fed a High Salt Diet. A. Polichnowski, Hepatic Expression of Glucose and Lipid Metabolism K. Griffin, P. Sethupathi, M. Picken, J. Long, G. Related Genes. B. Luo, D. Xiang, P. Chen, Y. Hu N Williamson, A. Bidani. Hines VA Hosp. and Loyola Second Military Med. Univ., Shanghai, Shanghai Univ.-Chicago and Illinois Inst. of Technol. (964.7) Univ. of Sport and Naval Med. Res. Inst., Shanghai. (1014.1) 332. INNATE IMMUNE FUNCTIONS OF 9:15 Exercise Mitigates Cognitive Functions through EPITHELIAL CELLS Mitochondrial Remodeling in Type-2 Diabetes. A. Kalani, P. Chaturvedi, L.J. Winchester, S.C. Featured Topic Tyagi, N. Tyagi. Univ. of Louisville. (1014.2) 9:30 Roux-en-Y Gastric Bypass Surgery Enhances (Sponsored by: APS Gastrointestinal and Liver Contraction-Mediated Glucose Metabolism in Primary Physiology Section) Human Myotubes. J.M. Hinkley, K. Zou, S. Park, K. Mon. 8:00 am—San Diego Convention Center, Room 25A Turner, D. Zheng, J.A. Houmard. East Carolina Univ. (1014.3) Chaired: M. Frey 9:45 Defective Autophagy Causes a Maladaptive Cardiac Inflammation/Immunity Phenotype to Exercise That Leads to Premature Death and FGF21-Mediated Protection against Obesity and Barriers: Endothelium and Epithelium Insulin Resistance. V.A. Lira, A. Kronemberger, 8:00 Paneth Cells as Mediators of Homeostasis in the Small J.A. Call, H.M. Caster, R.O. Pereira, R.C. Laker, M. intestine. C. Bevins. Univ. of California, Davis Sch. Zhang, Z. Yan. Carver Col. of Med., Univ. of Iowa, of Med. Univ. of Georgia and Univ. of Virginia. (1014.4) 8:30 Loss of PTPN2 in Intestinal Epithelial Cells Upregulates a Novel STAT-Dependent Mechanism of Claudin-2 334. MODULATORY INFLUENCE OF EXERCISE ON Expression. M. Krishnan, D.F. McCole. Univ. of PHYSIOLOGICAL FUNCTION WITH AGING California, Riverside. (1017.1) 8:45 ErbB3 Negatively Regulates Homeostatic Paneth Cell Symposium Numbers. D. Almohazey, J.J. Hsieh, C.V. Vossler, M.R. Frey. Children’s Hosp. Los Angeles, Univ. of So. (Sponsored by: APS Environmental and Exercise California. (1017.2) Physiology Section) 9:00 Stressor-Enhanced Infectious Colitis Is Due to Aberrant Mon. 8:00 am—San Diego Convention Center, Room 26 Colonic Epithelial Cell Signaling. A. Mackos, M.T. Bailey. Nationwide Children’s Hosp. Res. Inst. and Chaired: D.R. Seals and F. Booth The Ohio State Univ. (1017.3) Skeletal Muscle Physiology 9:15 Intestinal Mucus Acts Is a Maturation Factor for Dendritic Cells. M.A. Engevik, R.S. Fultz, B.P. Ganesh, J. Exercise, Aging, and Disease Versalovic. Baylor Col. of Med. (1017.4) Sex Differences 9:30 The Effect of JAK-Inhibitor Tofacitinib on Intestinal Epithelial Barrier Function. A. Sayoc, M. Krishnan, 8:00 Exercise, Physical Function and Mobility with Aging. D.F. McCole. Univ. of California, Riverside. (1017.5) R. Fielding. USDA at Tufts Univ. 9:45 Intestinal Epithelial IL-15 Overexpression Enhances γδ 8:30 Effects of Exercise and Gonadal Aging on Body T Cell Mucosal Surveillance. K.L. Edelblum, B. Jabri, Composition and Bone Density. W. Kohrt. Univ. of J.R. Turner. Rutgers New Jersey Med. Sch. and Univ. Colorado, Denver Anschutz Med. Campus. of Chicago. (1017.6) 9:00 Exercise, Oxidative Stress, Inflammation and Vascular Aging. D. Seals. Univ. of Colorado, Boulder. 9:30 Exercise, Functional Connectivity and Cognitive Performance with Aging. M. Voss. Univ. of Iowa.

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335. NOVEL INSIGHTS IN VASCULAR DISEASE IN 8:15 Thyroid Hormone Deficiency Disrupts Respiratory METABOLIC SYNDROME Control Development and Responses to Hypoxia in Newborn Rat. J-P. Rousseau, R. Kinkead. Univ. Symposium Laval, Québec. (773.9) 8:30 Sympathetic Vasoconstriction Is Attenuated in Young (Sponsored by: APS Cardiovascular Section) Women during Hypoxia and Cold Pressor Test. Mon. 8:00 am—San Diego Convention Center, Room 22 A.J. Ross, M.D. Muller, J.C. Luck, J. Cui, L.I. Sinoway. Hershey Heart and Vasc. Inst., Penn State Chaired: D. Weber and D. Stepp Col. of Med. (1001.2) 8:45 Pericytes Improve Motor Recovery after Spinal Cord Diabetes, Metabolic Syndrome Injury in Both Sexes. J.N. Mayo, S.E. Bearden. Univ. Metabolism and Metabolic Disease of Melbourne and Idaho State Univ. (1210.3) 9:00 Heightened Anaphylaxis Reaction in Female Mice Is 8:00 Improving Vascular Health in Obesity: Can We Bottle Associated with Increased Synthesis of Mast Cell Exercise? D. Stepp. Georgia Regents Univ. Secretory Granule-Associated Immune Mediators. 8:30 Deregulated Apoptosis and Proliferation are Key E. Mackey, S. D’Costa, C. Pohl, S. Ayyadurai, S. Components of Impaired Coronary Collateral Growth Laster, A.J. Moeser. North Carolina State Univ., GI in the Metabolic Syndrome. P. Rocic. New York Stress Biol. Lab., East Lansing, Univ. of North Carolina Med. Col. at Chapel Hill and Michigan State Univ. (1023.1) 9:00 Role of Perivascular Adipose Tissue in the Progression 9:15 Estradiol Facilitates a More Rapid Natriuretic Response of Coronary Vascular Dysfunction and Disease. to a High Salt Diet in Female Rats. E.Y. Gohar, D.M. J. Tune. Indiana Univ. Pollock. Univ. of Alabama at Birmingham. (1216.8) 9:30 Vascular Smooth Muscle Phenotype Plays A Critical 9:30 Sexual Dimorphic Expression of Renal Claudins, Role in Abnormal Coronary Artery Remodeling in Water Channels and Transporters Accounts for the Metabolic Syndrome. S. Gupte. New York Med. Col. Downstream Shift in Salt and Volume Reabsorption Along the Nephron in Female versus Male Rats. 336. PUBLISHING 101: HOW TO GET YOUR WORK L.C. Veiras, L. Pei, A.S.L. Yu, A.A. McDonough. PUBLISHED AND AVOID ETHICAL MINEFIELDS Keck Sch. of Med., Univ. of So. California and Univ. of Kansas Med. Ctr. (967.29) Symposium 9:45 Mitochondria-eNOS-Estrogen Axis Provides Pathway to (Sponsored by: APS Publications Committee) Protection against Stroke. I. Rutkai, S.V. Wunnava, I. Merdzo, P.V. Katakam, D.W. Busija. Tulane Univ. Mon. 8:00 am—San Diego Convention Center, Room 28B (953.9)

Chaired: C.D. Sigmund and R. Scheman 338. AVIAN OSMOREGULATION: UNIQUE Career Development SOLUTIONS, UNANSWERED QUESTIONS 8:00 Choosing A Journal, Authorship and Peer Review. C. Sigmund. Univ. of Iowa. Featured Topic 8:30 Ethical Minefields I: Plagiarism and Data Duplication. (Sponsored by: APS Comparative and Evolutionary K. Barrett. UCSD. Physiology Section) 9:00 Ethical Minefields Ii: Image Manipulation. C. Bennett. APS. Mon. 10:30 am—San Diego Convention Center, Room 25C

9:30 Meet the Editors Panel. B. Joe, N. Bunnett. Univ. of Chaired: K. Sweazea and D. Goldstein Toledo Col. of Med., Monash Inst. of Pharmaceut. Sci. Ion Transport 337. SEX DIFFERENCES IN HEALTH AND DISEASE Environmental Stress

Featured Topic Barriers: Endothelium and Epithelium (Sponsored by: APS Trainee Advisory Committee) 10:30 The Past, Present, and Future of Avian Osmoregulation Research. E. Braun. Univ. of Arizona. Mon. 8:00 am—San Diego Convention Center, 11:00 Countercurrent Urine Concentration and Role of Ballroom 20A Aquaporins in Avian Kidneys. H. Nishimura. Univ. of Chaired: D. Ilatovskaya and C. Banek Tennessee, Memphis. 11:30 The Integration of Gastrointestinal and Renal Function Sex Differences in Nectar-Feeding Birds. T.J. McWhorter. Sch. of Animal & Vet. Sci., Univ. of Adelaide. (976.3) 8:00 Differential Effects of Menopausal Hormone 11:45 Avian Osmoregulation in Flight: Unique Metabolic Formulations on Plasma Orexin A Levels in Women Adaptations Present Novel Challenges. A.R. Gerson, of the Kronos Early Estrogen Prevention Study. C. Guglielmo. Univ. of Massachusetts Amherst and D. Cintron, J. Beckman, J. Muthuvel, V. Miller. Mayo Univ. of Western Ontario. (976.1) Clin., Univ. of Puerto Rico-Med. Sci. Campus, San 12:00 Water Balance in Desert Birds – Challenges in a Rapidly Juan and St. Olaf Col., MN. (1248.1) Warming Environment. B.O. Wolf. Univ. of New Mexico. (976.4)

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12:15 Preliminary Examination of a Role for Insulin in the 340. ENVIRONMENTAL EXPOSURES, OXIDATIVE Regulation of Glucose Excretion in Mourning Doves STRESS, AND LUNG DISEASE (Zenaida macroura). K.L. Sweazea, E.J. Braun. Arizona State Univ. and Univ. of Arizona. (976.2) Featured Topic (Sponsored by: APS Respiration Section) 339. CELL SIGNALING: PROTEINS, PATHWAYS, AND MECHANISMS Mon. 10:30 am—San Diego Convention Center, Room 25B

Chaired: C. Waters Featured Topic 10:30 Molecular Mechanisms Linking Air Pollution and (Sponsored by: APS Cell and Molecular Asthma Development in infants. S. Cormier. Univ. of Physiology Section) Tennessee Hlth. Sci. Ctr. Mon. 10:30 am—San Diego Convention Center, Room 25A 11:00 Protective Role of Ergothioneine from Tobacco Smoke- Induced Oxidative Stress In Vitro and In Vivo. Chaired: M. Rao C. Ehrhardt, M.A. Selo, C.G. Clerkin, B.N. Talbot, Inflammation/Immunity J.J. Walsh, N. Nakamichi, Y. Kato, J.B. Lewis, P.R. Reynolds, S. Nickel. Sch. of Pharm. and Pharmaceut. 10:30 Loss of the Inhibitory G-Protein, G , Protects against M z Sci., Trinity Col. Dublin, Kufa Univ., Iraq, Kanazawa O Type I Diabetes-Like Hyperglycemia by Stimulating Univ., Japan and Brigham Young Univ. (982.1) Islet Signaling Pathways That Promote Beta-Cell 11:15 Mechanisms Involved in the Antioxidant Properties N Function and Survival. R.J. Fenske, M.T. Cadena, of Azithromycin in Lung Epithelial Cells Stimulated A.L. Brill, N.A. Truchan, M.E. Kimple. Univ. of with Cigarette Smoke Extract. S. Cuevas, Y. Yang, Wisconsin-Madison and William S. Middleton Mem. I. Armando, P.A. Jose. George Washington Univ. Veterans Hosp. (969.28) and Univ. of Texas, Galveston. (982.2) 10:45 Chenodeoxycholic Acid Initiates Distinct Signaling 11:30 Inter-strain Variation in Mouse Mitochondrial Genome - Mechanisms to Stimulate Cl Transport in Intestinal and Effects of Oxidative Stress. K.C. Verhein, A. and Non-intestinal Epithelial Cells. J. Domingue, A. Burkholder, J.L. Nichols, Z. McCaw, J. Marzec, V. George, M. Ao, M. Bijvelds, H. de Jonge, J. Sarathy, Panduri, W. Gladwell, N. Reeves, J. Malphurs, G. M.C. Rao. Univ. of Illinois at Chicago, Erasmus MC, Solomon, T. Wiltshire, D. Fargo, D. Bell, B. Van Rotterdam and Benedictine Univ., IL. (969.25) Houten, S.R. Kleeberger. NIEHS, NIH, Research 11:00 Enhancement of Neutrophil Antimicrobial Activity by the Triangle Park, Eschelman Sch. of Pharm., Univ. Breast Cancer Drug Tamoxifen. R. Flores, P.A. Insel, of North Carolina at Chapel Hill and Univ. of V. Nizet, R. Corriden. UCSD. (969.14) Pittsburgh. (982.3) 11:15 Danger Signaling, IL-33 Secretion, and Allergic 11:45 Investigation of the Cardiotonic , inflammation following Airway Exposure to Fungal Marinobufagenin and Resibufogenin, in the Acute Allergens. S. O’Grady. Univ. of Minnesota, St. Paul. Respiratory Distress Syndrome. M.M.K. Abbas, 11:45 A-Kinase Anchoring Proteins Coordinate the Q. Chen, A. Das, J. Oliver, W. Jiang, B. Moorthy, Contractile Phenotype of Airway Smooth Muscle. B. Patel, K. Morin, J. Puschett. Texas A&M Col. of W.J. Poppinga, B. Han, C.R. Elzinga, A.J. Halayko, Vet. Med. and Biosci., Texas Children’s Hosp., Baylor H. Meurs, M. Schmidt. Univ. of Groningen and Col. of Med. and Univ. of Texas-Houston and Mem.- Univ. Med. Ctr. Groningen, Netherlands and Univ. of Hermann Hosp., Houston. (982.4) Manitoba. (969.29) 12:00 Alveolar Acid Injury Causes Endothelial Mitochondrial 12:00 Mutation in the PPARγ Ligand Binding Domain Impairs Depolarization. R.F. Hough, G.A. Gusarova, M.N. the AntiiInflammatory Action of PPARγ. M. Mukohda, Islam, J. Bhattacharya. Columbia Univ. Med. Ctr. P. Ketsawatsomkron, M. Stump, X. Liu, D.F. Guo, K. (982.5) Rahmouni, F.W. Quelle, C.D. Sigmund. Univ. of Iowa 12:15 Alterations in the Expression of Profilin1/pVASP-S157 and Nortis Inc., Seattle. (969.12) and Cofilin1/pVASP-S239 in Perinatal Inflammation/ 12:15 N-Cadherin Adhesion Modulates RhoGTPase Signaling Neonatal Hyperoxia-Induced Lung Injury. M. Ali, K.M. to Promote Endothelial Barrier Integrity. K.J. Kruse, Heyob, L.K. Rogers. Nationwide Children’s Hosp. F. Huang, S. Ying, S. Vogel, A. Malik, Y. Komarova. and The Ohio State Univ. (982.6) Univ. of Illinois at Chicago. (969.33)

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103 PHYSIOLOGY MONDAY

341. EPITHELIAL PHYSIOLOGY AND TRANSPORT II 343. HYDRATION PHYSIOLOGY: FROM CELLS TO SYSTEMS AND CLINICAL HEALTH OUTCOMES Featured Topic Symposium (Sponsored by: APS Epithelial Transport Group) (Sponsored by: APS Water and Electrolyte Mon. 10:30 am—San Diego Convention Center, Room 28A Homeostasis Section) Chaired: K. Hamilton and M. Helms Mon. 10:30 am—San Diego Convention Center, Room 22 Ion Transport Chaired: L.E. Armstrong Hypertension Transporters/Channels/Barriers Barriers: Endothelium and Epithelium 10:30 Cell Physiology and Water Balance. F. Lang. Univ. 10:30 Steven C. Hebert Lecture. Salt Transport in the of Tübingen. Kidney and Lung: Transport Pathways Designed by 10:55 Water, Vasopressin and the Kidney. L. Bankir. INSERM, Committee. D. Eaton. Emory Univ. Chatillon, France. 11:15 The Mineralocorticoid Receptor (MR) Regulates 11:20 Dehydration-Induced Renal Injury: A Fructokinase- ENaC but Not NCC in Mice with Random MR Mediated Disease? M. Garcia. Univ. of Colorado Deletion. J. Czogalla, T. Vohra, D. Penton Ribas, M. Denver, Anschutz Med. Campus. Kirschmann, M. Carrel, J. Loffing. Univ. of Zürich 11:45 Vasopressin from Regulator to Disease Predictor. and Swiss NCCR Kidney.CH, Zürich. (1223.1) O. Melander. Lund Univ., Sweden. 11:30 Ankyrin G Alters ENaC Membrane Delivery to Increase 12:10 Defining and Assessing Hydration through Relevant Na+ Transport in the Distal Kidney Nephron. Biomarkers. E. Perrier. Danone Nutricia Res., C.A. Klemens, L. Kightlinger, X. Liu, R. Edinger, Palaiseau, France. M.B. Butterworth. Univ. of Pittsburgh. (1223.2) 11:45 Interleukin-6 Transactivation of the Mineralocorticoid 344. NEUROIMMUNE CROSSTALK IN THE GUT Receptor. B.M. Wynne, T.A. Kronk, O. Al-Khalili, R. Mallick, B. Ko, D.C. Eaton, R.S. Hoover. Emory Symposium Univ., Univ. of Chicago and Atlanta VA Med. Ctr., Decatur. (1223.3) (Sponsored by: APS Gastrointestinal and Liver 12:00 ASIC1a/α-ENaC Hybrid Channels Contribute to Alveolar Physiology Section) Fluid Clearance. P. Trac, M.M. Greenlee, O. Al- Mon. 10:30 am—San Diego Convention Center, Room 26 Khalili, D.C. Eaton. Emory Univ. (1223.4) 12:15 Regulation of ENaC by Specific Palmitoyltransferases. Chaired: B.D. Gulbransen and A.E. Lomax A. Mukherjee, Z. Wong, P.A. Poland, N. Montalbetti, Neurobiology M. Butterworth, M. Fukata, T.R. Kleyman, R.P. Hughey. Univ. of Pittsburgh and Natl. Inst. for Physiol. Inflammation/Immunity Sci., Okazaki, Japan. (1223.5) Microbiome 342. EXERCISE AND CANCER: FROM 10:30 Modulation of the Intestinal Immune System by the CARDIOVASCULAR OUTCOMES TO THE Nervous System. G. Boeckxstaens. Univ. Hosp. TUMOR MICROENVIRONMENT Leuven, Catholic Univ. Leuven, Belgium. 11:00 Plasticity of the Autonomic Nervous System in Response Symposium to Gastrointestinal inflammation. A. Lomax. Queen’s Univ., Canada. (Sponsored by: APS Environmental and Exercise 11:30 Neuro-Endocrine-Immune Pathways Contribute to Physiology Section) the Pathophysiology of Irritable Bowel Syndrome. D. O’Malley. University Col. Cork. Mon. 10:30 am—San Diego Convention Center, Room 23 12:00 The Role of Enteric Glial Cells as a Bridge between Chaired: B.J. Behnke and L. Jones Intestinal Immune and Nervous Systems. B. Gulbransen. Michigan State Univ. Exercise, Aging, and Disease Cancer Biology 10:30 Accelerated Cardiovascular Disease in Cancer Patients and the Cardioprotective Role of Exercise. J. Scott. Are You Tweeting about EB 2016? NASA Johnson Space Ctr. 11:00 Cancer as a Model of Accelerated Physiological Aging. To Tweet use #expbio L. Jones. Mem. Sloan Kettering Cancer Ctr. 11:30 Tumor Vascular (Dys) Function and Hemodynamics during Exercise. B. Behnke. Kansas State Univ. Be sure to follow EB on 12:00 Exercise Based Modulation of the Tumor Facebook and Twitter. Microenvironment – Impact on Anticancer Therapies. D. Siemann. Univ. of Florida Hlth. Cancer Ctr.

104 MONDAY PHYSIOLOGY

345. NOVEL MECHANISMS OF GENE REGULATION 348. EDWARD F. ADOLPH DISTINGUISHED IN THE KIDNEY LECTURESHIP OF THE APS ENVIRONMENTAL AND EXERCISE PHYSIOLOGY SECTION Symposium Lecture (Sponsored by: APS Renal Section) Mon. 2:00 pm—San Diego Convention Center, Room 24 Mon. 10:30 am—San Diego Convention Center, Room 27 Oxidative Stress Chaired: M. Gumz and R. Hoover Exercise: Teaching Myocytes New Tricks. S. Powers. Transporters/Channels/Barriers Univ. of Florida. 10:30 Circadian Clock Protein-Mediated Regulation of Renal Sodium Transport. M. Gumz. Univ. of Florida. 349. CARDIOPULMONARY EFFECTS OF 11:00 Medullary Class1 Histone Deacetylase Enzymes and ENVIRONMENTAL STRESSORS Fluid-Electrolyte Balance. K. Hyndman. Univ. of Alabama at Birmingham. Featured Topic 11:30 miRNA, Fibrosis and the Proximal Tubule. I. Armando. George Washington Univ. Mon. 3:15 pm—San Diego Convention Center, Room 28A M O 12:00 The Role of KLF15 as a Transcriptional Regulator of Chaired: L. Wold Podocyte Differentiation. S. Mallipattu. Stony Brook N Univ. Sch. of Med. Myocardial Infarction/Heart Failure Environmental Stress 346. SOLOMON A. BERSON DISTINGUISHED LECTURE OF THE APS ENDOCRINOLOGY AND 3:15 Deployment-Related Toxicants: Effects on the METABOLISM SECTION Cardiopulmonary System. M. Falvo. VA New Jersey Hlth. Care Syst. Lecture 3:45 Thermoregulatory and Ventilatory Responses in Humans with a Patent Foramen Ovale during Passive Cooling Mon. 10:30 am—San Diego Convention Center, Room 24 While Immersed in 20°C Water. J.T. Davis, M.W. Hay, A.M. Hardin, A.T. Lovering. Univ. of Oregon. (954.9) Diabetes, Metabolic Syndrome 4:00 Influence of Acute Lower Limb Heating on Clinical Metabolism and Metabolic Disease Measures and Functional Capacity in Peripheral Artery Disease. T.K. Pellinger, C.B. Pearce, G.H. Cellular Mechanisms of Insulin Resistance: Implications Simmons. Salisbury Univ. and Univ. of Missouri- for Obesity, Type 2 Diabetes, and the Metabolic Columbia Sch. of Med. (954.8) Syndrome. G. Shulman. HHMI, Yale Univ. Sch. 4:15 Maternal Separation Stress Causes Mis-p[rogramming of Med. of Arterial Smooth Muscle Maturation. J. Reho, S.A. Fisher. Univ. of Maryland Sch. of Med. (954.4) 347. THYROID HORMONE MODULATION OF 4:30 Exposure to PM2.5 during the First Trimester Contributes CARDIAC FUNCTION AND REMODELING: to Adult Cardiac Dysfunction. V. Tanwar, M. Gorr, C. BENCH TO BEDSIDE Eichenseer, L. Wold. The Ohio State Univ. (954.7) 4:45 Endothelial Hyper-permeability and Cardiomyocyte Symposium Dysfunction following Coronary Artery Bypass Grafting. M. Velten, G.D. Duerr, M. Hamiko, S. Frede, Mon. 10:30 am—San Diego Convention Center, Room 28B L.K. Rogers, G. Baumgarten, A. Hoeft, T. Hilbert. Chaired: M. Portman and A.M. Gerdes Univ. Med. Ctr. Bonn and Nationwide Children’s Hosp., Columbus, OH. (954.3) Myocardial Infarction/Heart Failure 5:00 Wrap-Up. L. Wold. The Ohio State Univ. 10:30 Thyroid Hormone and Heart Failure. A. Gerdes. New York Inst. of Technol. 350. CARL GOTTSCHALK DISTINGUISHED 11:00 Posttranslational Regulation of Thyroid Hormone LECTURESHIP OF THE APS RENAL SECTION Receptors during Cardiac Hypertrophy and Remodeling. M. Willis. Univ. of North Carolina. Lecture 11:30 Thyroid Hormone Regulation of Postnatal Cardiomyocyte Proliferation. A. Husain. Emory Univ. Mon. 3:15 pm—San Diego Convention Center, Room 24 12:00 Triiodothyronine Supplementation Modulates Cardiac Aldosterone and Hypertension: What’s the DCT Got to Metabolism and Improves Clinical Outcomes Do with It? D. Ellison. Oregon Hlth. & Sci. Univ. during Stress-Induced Sick Euthyroid Syndrome. M. Portman. Seattle Children’s Hosp. and Univ. of Washington.

105 PHYSIOLOGY MONDAY

351. ENVIRONMENTAL REGULATORS 4:00 Lipopolysaccharide-Induced IL-6 and TNF-Alpha OF INFLAMMATION: GENETIC AND Expression in Neonatal Rat Nucleus Tractus Solitarii EPIGENETIC IMPLICATIONS In Vivo. R. Johnson, S. Murray, C. Wilson. Loma Linda Univ. (1262.3) Featured Topic 4:15 The Src Family Tyrosine Kinase fyn Protects Mice from Inflammation-Induced Lung Injury. Y.D. Jin, Y. Liu, (Sponsored by: APS Physiological Genomics Group) J.K. Trittmann, L.G. Chicoine, B. Chen, L.D. Nelin. Nationwide Children’s Hosp. and The Ohio State Mon. 3:15 pm—San Diego Convention Center, Room 25A Univ. (1262.6) Chaired: K. Claycombe and S. Meydani 4:30 Effects of Two-Hit Lipopolysaccharide Administration on Basal Inspiratory Motor Activity in Spontaneously 3:15 Introduction. K. Claycombe. USDA, Grand Forks. Breathing Adult Male C57BL/6 Mice. R.M. Wadolowski, 3:30 Epigenetic Regulation of Macrophage Polarization and M.S. Ahmad, M. Wang, I.C. Solomon. Stony Brook Renal Inflammation. S. Pushpakumar, L. Ren, R. Univ. (1262.10) Biswas, U. Sen. Univ. of Louisville. (771.11) 4:45 Differential Effects of Systemic versus Intratracheal 3:45 Vitamin D Supplementation and DNA Methylation Lipopolysaccharide Administration on Inspiratory Patterns during Pregnancy and Lactation in Mothers Motor Output in Anesthetized Spontaneously and Infants. C.M. Anderson, D.K. Thiele, J.L. Ralph, Breathing Sprague Dawley Rat. M. Wang, R.M. D. Perley, J.E. Ohm. Col. of Nursing, The Ohio State Wadolowski, M.S. Ahmad, I.C. Solomon. Stony Univ., Sch. of Nursing, Oregon Hlth. & Sci. Univ. and Brook Univ. (1262.12) Col. of Nursing and Prof. Disc. and Sch. of Med. and 5:00 Sensitizing Effects of Chronic Pretreatment with Tumor Hlth. Sci., Univ. of North Dakota. (1028.3) Necrosis Factor Alpha on Vagal Pulmonary Afferent 4:00 The Essence of Quiescence: Understanding the Roles Sensitivity in Mice. R-L. Lin, L-Y. Lee. Univ. of of Histone Modification H4K20me3 and the Histone Kentucky. (1262.13) Modifying Enzyme Suv4-20h2 in Cellular Quiescence. A.Z. Corvalan, A.G. Evertts, W.E. Lowry, H.A. Coller. UCLA and Princeton Univ. (1028.5) 353. JOSEPH ERLANGER DISTINGUISHED 4:15 Histone Deacetylase Inhibitors Exhibit Enhanced LECTURESHIP OF THE APS CENTRAL Kidney Functions in Guanylyl Cyclase-A/Natriuretic NERVOUS SYSTEM SECTION Peptide Receptor-A Gene-Disrupted Mice: Role of Epigenetic Mechanisms. P. Kumar, R. Periyasamy, Lecture U. Subramanian, K.N. Pandey. Tulane Univ. Hlth. Mon. 3:15 pm—San Diego Convention Center, Room 23 Sci. Ctr. (771.2) 4:30 Searching for the Genetic Basis of Impaired Placentation Neurobiology in the Dahl Salt Sensitive Rat Model of Superimposed Neurophysiology Preeclampsia. J.M. Sasser, A.C. Johnson, M.R. Garrett. Univ of Mississippi Med. Ctr. (771.8) Immune Stress and the Brain: Synaptic Substrates of 4:45 RNA Next Gen Sequencing of Kidneys from Diabetic Sickness. Q. Pittman. Univ. of Calgary, Canada. Rats Provides Insights into Reno-protective Effects of Vitamin D Receptor Activation. S.S. Prabhakar, K. 354. NEGOTIATING FOR SUCCESS! Kam, R. Kottapalli, C. Yego. Texas Tech Univ. Hlth. Sci. Ctr. (771.3) Symposium 5:00 MicroRNAs Target Decidual Angiogenic Factors during Early Pregnancy in BPH/5, a Spontaneous Mouse (Sponsored by: APS Women in Physiology Committee)

Model of Preeclampsia. J. Xia, S. Baxter, J. Grenier, Mon. 3:15 pm—San Diego Convention Center, Room 25C R.L. Davisson, J.L. Sones. Cornell Univ. (1028.14) Chaired: K.M. Mathis and K.L. Sweazea

352. INFLAMMATION AND ITS INFLUENCE ON LUNG Career Development FUNCTION AND RESPIRATORY CONTROL 3:15 Making Your Personality Type Work for You. Featured Topic 3:45 Negotiation 101: Skills Everyone Needs. P. Blair. Manpower, San Diego. (Sponsored by: APS Respiration Section) 4:05 Negotiation 201: Industry Sales/Marketing. K. Atkinson. Illumina, Inc. Mon. 3:15 pm—San Diego Convention Center, Room 28B 4:15 Negotiation 201: Industry R&D. M. Alonso-Galicia. Chaired: S.M. Wilson and C.G. Wilson Bayer Healthcare LLC, San Francisco. 4:25 Negotiation 201: Academia Research. K. Barrett. UCSD. 3:15 Intermittent Hypoxia-Dependent Regulation of Microglial 4:35 Negotiation 201: Academia Teaching. J. Uno. Elon Univ. Activities and Respiratory Plasticity. J. Watters. Univ. 4:45 Negotiation 201: Military. K. Ryan. U.S. Army Inst. of of Wisconsin-Madison. Surg. Res., TX. 3:45 Ventilatory Acclimatization to Hypoxia Requires Early 4:55 Panel Discussion. Microglia Activation. J.A. Stokes, T.E. Arbogast, F.L. Powell. UCSD. (1262.2)

106 MONDAY PHYSIOLOGY

355. ROLE OF EPITHELIUM IN INNATE DEFENSE: 357. THE CONTROL OF SKELETAL MUSCLE MORE THAN A BARRIER ATROPHY IN RESPONSE TO DISUSE: CLINICAL/ PRECLINICAL CONTENTIONS AND FALLACIES Symposium OF EVIDENCE

Mon. 3:15 pm—San Diego Convention Center, Ballroom 20A Symposium

Chaired: J.P. Garnett (Sponsored by: APS Endocrinology and Metabolism Section) Transporters/Channels/Barriers Mon. 3:15 pm—San Diego Convention Center, Room 22 Barriers: Endothelium and Epithelium Chaired: P.J. Atherton and C. Lang Inflammation/Immunity Diabetes, Metabolic Syndrome 3:15 The Retinal Pigment Epithelial Cell: Key Role in Ocular Innate Immunity. B. Detrick. Johns Hopkins Univ. Skeletal Muscle Physiology Sch. of Med. 3:15 Is there a Role of insulin Resistance in Driving Muscle 3:55 Epithelial Innate Immune Pathways in Intestinal Disuse Atrophy? P. Greenhaf. Univ. of Nottingham. M Homeostasis. K. Maloy. Univ. of Oxford. 3:45 The Regulation of Protein Metabolism in Human Disuse O 4:35 3D Lung Models for Studying Host-Pathogen Atrophy: Now and the Future. S. Phillips. McMaster N interactions and Antimicrobial Treatment Efficacy In Univ., Canada. Vitro. A. Crabbe. Univ. of Ghent. 4:15 The Regulation of Protein Metabolism in Pre-Clinical 5:00 Panel Discussion. Models of Disuse Atrophy: Now and the Future. S. Bodine. Univ. of California, Davis. 356. SCIENTIFIC FOUNDATION FOR CLINICAL 4:45 Insights into Atrophy Using Systems Approaches: Now PRACTICE: MORE THAN A PILE OF FACTS and the Future. C. Adams. Univ. of Iowa.

Symposium 358. TRANSCRIPTIONAL AND EPIGENETIC (Sponsored by: APS Teaching of Physiology Section) REGULATION OF CARDIO- RESPIRATORY HOMEOSTASIS Mon. 3:15 pm—San Diego Convention Center, Room 25B

Chaired: M.L. Alacórn Fortepiani and P. Sanchez-Diaz Symposium

Education (Sponsored by: APS Hypoxia Group) 3:15 Application of Core Concepts in Physiology to Mon. 3:15 pm—San Diego Convention Center, Room 26 Student-Centered Learning and Scientific Teaching. Chaired: G.L. Semenz and J-M. Ramirez J. McFarland. Edmonds Community Col., WA. 3:35 Teaching Basic Sciences When Time is Tight: Blended Oxidative Stress Learning, Just in Time Teaching, and In-Class Case Hypertension Discussion. P. Sanchez-Diaz. Rosenberg Sch. of Optom., Univ. of the Incarnate Word, San Anotnio. Neurobiology 3:55 Building A Solid Pathophysiology Foundation for Clinical 3:15 Regulation of Cell Metabolism by Hypoxia-Inducible Practice in Optometry. M. Lourdes Fortepiani. Factors. G. Semenza. Johns Hopkins Univ. Sch. Rosenberg Sch. of Optom., Univ. of the Incarnate of Med. Word, San Anotnio. 3:45 Epigenetic Regulation of Redox State inder Intermittent 4:15 Teaching Physiology in a Medical School. L. Harrison- Hypoxia. J. Nanduri. Univ. of Chicago. Bernard. LSU Hlth. Sci. Ctr. Sch. of Med. 4:15 Transcriptional Mechanisms Underlying Hypoxia- 4:35 Panel Discussion. Induced Pulmonary Hypertension. L. Shimoda. Johns Hopkins Univ. Sch. of Med. 4:45 Genetic Determinants of Red Blood Cell Production. J. Prchal. Univ. of Utah.

107 PHYSIOLOGY MONDAY

359. VAGAL-RESPIRATORY COUPLING AND ITS 360. ERLANGER LECTURE MINISYMPOSIUM IMPLICATIONS IN HEALTH AND DISEASE Minisymposium Featured Topic (Sponsored by: APS Central Nervous System Section) (Sponsored by: APS Neural Control and Autonomic Mon. 4:15 pm—San Diego Convention Center, Room 23 Regulation Section) Chaired: Q.J. Pittman and S.S. Stocker Mon. 3:15 pm—San Diego Convention Center, Room 27 Neurobiology Chaired: M. Dutschmann Neurophysiology Neurobiology 4:15 Neonatal Maternal Separation Increases Microglial Neurophysiology Activation in Brainstem Regions Controlling the 3:15 Origins of Cardiac Vagal Tone and Its Modulation by the Laryngeal Chemoreflex. C. Baldy, S. Boisjoly- Respiratory Control Circuit. D. Farmer. Florey Inst. Villeneuve, S. Fournier, M-E. Tremblay, R. Kinkead 3:45 Interaction of Vagal Bradycardia and Respiratory CHU de Québec, Laval Univ. (991.2) Failure in Animal Models of Sudden Death in 4:30 Dopamine System Regulation of Inhibition in an Animal Epilepsy. F. Kalume. Seattle Children’s Hosp. Univ. Model of Interneuron Transcriptional Dysregulation of Washington. and Hippocampal Circuit Dysfunction. L. Brady, 4:15 Quantification of Cardiac Baroreflex Sensitivity during A. Bartley, Q. Li, L. Dobrunz. Univ. of Alabama at Autonomic Stimulation. P. Sharma, M. Mavai, O.L. Birmingham. (1284.7) Bhagat, M. Murugesh, S. Sircar. All India Inst. of 4:45 Inhibition of Endocannabinoid Degradation Improves Med. Sci., Jodhpur. (1236.1) Recovery of Neurobehavioral Function and Resolution 4:30 Dynamics of Cardio-respiratory Coupling during Sighs of Neuroinflammation and Synaptic Hyperexcitability in Conscious Rats. E. Bondarenko, E. Nalivaiko. in a Rodent Model of Traumatic Brain Injury. Univ. of Newcastle, Australia. (1236.2) J.P. Mayeux, P. Katz, S. Edwards, J. Middleton, 4:45 Improvement of Vagal Tone and Reduction in the Blood P. Molina. LSU Hlth. Sci. Ctr., New Orleans. (993.5) Pressure by Physical Training in Aging Spontaneously 5:00 Depletion of Brain Perivascular Macrophages Mitigates Hypertensive Rats. L.O. Dellacqua, L.C. Michelini, Depressive-Like Behavioral Consequences of Chronic C. Hindmarch, J.F.R. Paton, D. Murphy, V. Antunes. Mild Stress. J-S. Grigoleit, E. Alvarez, C.B. Farrokhi, Univ. of São Paulo and Univ. of Bristol. (1236.3) P.E. Sawchenko. Salk Inst. for Biol. Studies. (991.8) 5:00 Protection of Renal Ischemia/reperfusion Injury by Optogenetic Stimulation of the C1 Neurons. C. Abe, T. Inoue, A. Inglis, K. Viar, L-P. Huang, H. Ye, D. Rosin, R. Stornetta, M. Okusa, P. Guyenet. Univ. of Virginia. (1236.4)

108 TUESDAY, APRIL 5 Across Societies

361. CAREER DEVELOPMENT WORKSHOPS 10:30 Ten Ways to Get Lucky in the Job Search. P. Clifford. Univ. of Illinois at Chicago, Med. Col. of Wisconsin Workshop and Marquette Univ. 11:00 Making Mistakes When Speaking: How to Handle Them. Tue. 9:00 am—San Diego Convention Center, Exhibit Hall D J. Blumenthal. Montgomery Col., MD. Career Development 1:00 Negotiation Strategies for Scientists Part 2. D. Behrens. Univ. of California, Berkeley. The following workshops will be held in the EB2016/FASEB 1:00 Selling Yourself to the Life Sciences Industry. J. Tringali. Career Center. Access to the Career Center is FREE to all Tringali & Assocs. Inc. registered Experimental Biology 2016 meeting attendees. 1:00 Creating Effective CV’s Cover Letters, Research Poster/Platform Presenter Preparation Workshop and & Teaching Statements. A. Green. Univ. of Practice Lab California, Berkeley. 1:00 How to Choose Your Ideal Career. B. Lindstaedt. UCSF. FASEB MARC Program will sponsor a Poster/Platform 1:00 Responsible Conduct of Research Part 3: Best Presenter Preparation Workshop and Practice Lab beginning Practices: Publication Practices & Authorship, Saturday, April 2, to provide FASEB MARC poster/oral Conflicts of Interest, and Research. S. Sodeke, T. presentation travel award recipients and other interested EB2016 Turner. Tuskegee Univ., Jackson State Univ. T student/postdoc attendees with an opportunity to practice their 2:30 Networking with Strangers is Required for Your Future. U presentations and obtain feedback from designated Workshop J. Blumenthal. Montgomery Col., MD. E Mentors/Coaches. If you would like to participate in this 2:30 Handshakes, Eye Contact, Small Talk: How to workshop/practice lab, sign-up onsite at the Career Center Successfully Network at a Conference. N. Saul. UCSF. beginning Saturday morning, April 2. First-come, first- 3:00 Nailing the Job Talk & Interview Prep. A. Green. Univ. of served. Limited space/session availability. California, Berkeley. 9:00 Negotiation Strategies for Scientists Part 1. D. Behrens. 3:00 Job Search in Academia & Industry. D. Behrens. Univ. Univ. of California, Berkeley. of California, Berkeley. 9:00 Understanding Search Committees & Finding Job Announcements. A. Green. Univ. of 362. TANG PRIZE IN BIOPHARMACEUTICAL California, Berkeley. SCIENCE AWARD LECTURE 9:00 Job Hunting in Biotech Part 3: Compensation Negotiation for Scientist Positions. B. Lindstaedt. UCSF. Lecture 10:00 Navigating the Protocol, Milestones & Graduate Degree (Sponsored by: Tang Prize Foundation, Taiwan) Requirements. H. Adams. H.G. Adams & Assocs. Inc., Norfolk, VA. Tue. 3:00 pm—San Diego Convention Center, Room 33ABC 10:00 Responsible Conduct of Research Part 2: Best Practices: Mentoring, Collaboration, Peer Review, Cancer Immunotherapy by PD-1 Antibody. T. Honjo. Data Management and Ownership. S. Sodeke, Kyoto Univ. Grad. Sch. of Med. T. Turner. Tuskegee Univ., Jackson State Univ. 10:30 Talking About Yourself: How to Interview Well. N. Saul. UCSF.

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109 ANATOMY TUESDAY Anatomy

363. CLINICAL APPROACH IN 365. WHAT CAN WE DO WHEN IT ALL FALLS CARDIOVASCULAR RESEARCH APART? REMEDIATION AND HOW TO HELP STUDENTS WHO ARE STRUGGLING Hybrid Symposium Hybrid Symposium (Cosponsored by: Brazilian Society of Anatomy) Tue. 8:30 am—San Diego Convention Center, Room 8 Tue. 8:30 am—San Diego Convention Center, Room 10 Chaired: P. Husmann Chaired: R.H. Cabral Education and Teaching Cardiovascular Biology Education 8:30 363.1 Parietal Valve of the Coronary Sinus: Morphological Features and Clinical Importance. N.E.V. de 8:30 365.1 Evaluating the Impact of Pre-matriculation Prates. Univ. of São Paulo. Instruction on Academic Performance in the Anatomical and 9:00 363.2 Comparative Cardiac Anatomy and Physiological Sciences. D.E. Chico, S. Smith, W-J.A. Chen, Transmyocardial Laser Revascularization. R. Halti Cabral. T.V. Peterson, A. Hairrell. Texas A&M Hlth. Sci. Ctr. Col. Univ. of São Paulo and Tiradentes Univ. Sch. of Med., Brazil. of Med. 9:30 363.3 Sodium Overload Induces Remodeling of 8:45 365.2 Prediction, Performance, and Adjustments: Aorta and Cardiac Arteries without Blood Pressure Changes in Medical Students’ Reflections on the First Gross Anatomy Mice. S. Lacchini, J.C.S. Silva, C.T. Lima, K.A. Viegas, T.C.S. Exam. L.A. Hoffman. Indiana Univ. Sch. of Med., Fort Wayne. Oliveira, P. Fiorino, V.M.A. Farah, R.H. Cabral. Univ. of São 9:00 365.3 Early Interventions: Promoting Success to Paulo, São Paulo State Univ., Botucatu and Presbiterian Univ. Prevent Remediation. A. Schutte, E. Kalb. Indiana Univ. Sch. Mackenzie, São Paulo. of Med. - Evansville. 9:45 363.4 Applied Anatomy of the Gastrocnemic Veins. 9:30 365.4 Remediation in an Integrated Medical School J. Aderval Aragão. Fed. Univ. of Sergipe and Tiradentes Curriculum – Lessons Learned. P. Ward. West Virginia Sch. of Univ., Brazil. Osteo. Med.

364. CRANIAL SUTURES AND THE PERIODONTAL 366. WRITTEN AND VISUAL COMMUNICATION: LIGAMENT - THE SOFT FORCES BEHIND DEVELOPING AN OUTSTANDING ABSTRACT SHAPING THE SKULL OR TEETH AND POSTER

Symposium Symposium

Tue. 8:30 am—San Diego Convention Center, Room 9 (Cosponsored by: AAA’s Advisory Committee for Young Anatomists) Chaired: A. Burrows Tue. 8:30 am—San Diego Convention Center, Room 7B Developmental Biology/Morphology Cochaired: K. Brown and L. Jerome-Majewska Bones/Muscle/Connective Tissue Professional Development 8:30 364.1 Supernumerary Sutures in the Zygoma and Their Impacts on Skull Modularity and Biomechanics. Q.C. Career Development Wang, P.C. Dechow. Texas A&M Univ. Baylor Col. of Dent. 9:00 364.2 Cranial Fibrous Connective Tissue Joints and Participants should sign up ahead of time and are asked Experiments in Their Growth. C.D. Byron. Mercer Univ., GA. to bring their own abstract/poster to the session. This is to 9:30 364.3 Transcriptional Control of Cranial Suture help prepare for future meeting presentations, not for the Development. R. Maxson, C. Teng, M. Ting, G. Crump. Univ. current meeting. of So. California. 367. CARDIOVASCULAR BIOLOGY PLATFORM

Platform

Tue. 10:30 am—San Diego Convention Center, Room 10 Cardiovascular Biology Georgios Kararigas is competing as a finalist in the Postdoctoral Platform Presentation Award and Vanessa Vrolyk is competing as a finalist in the Langman Graduate Platform Presentation Award

110 TUESDAY ANATOMY

10:30 367.1 Lung Inflammation and Pulmonary369. ANATOMY EDUCATION PLATFORM 2 Intravascular Macrophage Recruitment in L-Arginine-Induced Acute Necrotizing Pancreatitis in Mouse. V. Vrolyk, B. Platform Wobeser, L. Khanh, B. Singh. Western Col. of Vet. Med., Univ. of Saskatchewan. Tue. 10:30 am—San Diego Convention Center, Room 8 10:45 367.2 Repression but Not Deletion of β-Catenin Cochaired: V.D. O’Loughlin and K. Metzger Contributes to Heart Failure. G. Kararigas, L.C. Zelarayan, K. Toischer, H. Summer, I. Baczko, S. Golz, G. Hasenfuss, H. Education and Teaching Jarry, V. Regitz-Zagrosek. Charité Univ. Hosp., Berlin, Georg- Education August-Univ. Goettingen and Bayer HealthCare, Wupperal, Germany and Univ. of Szeged, Hungary. Evidence-Based Approaches to Anatomy Education 11:15 367.4 Ambient Ultra Fine Particle Impair Vascular 10:30 369.1 Student Approaches to Anatomy Learning Repair via Notch Signaling. K.I. Baek. UCLA. Are Influenced by Clinically Relevant Peer-Peer Teaching. M. 11:30 367.5 The Methyl Donor Betaine Prevents Congenital Lazarus, J. Dos Santos, P. Haidet, T. Whitcomb. Monash Defects Induced by Prenatal Alcohol Exposure. M. Watanabe, Univ., Australia and Penn State G. Karunamuni, Y.Q. Doughman, M.M. Sheehan, P. Ma, L.M. 10:45 369.2 The Embryology Educator Experience: A Peterson, K.K. Linask, M.W. Jenkins, A.M. Rollins. Case Comprehensive Survey of Faculty and the Generation of Western Reserve Univ. and Univ. of South Florida. a Phenomenology of Embryology Education. K. Cassidy. 11:45 367.6 Reelin Signaling in Cardiovascular Indiana Univ. Development. D. Kim, A. Poles, G. Gorski, C.J. Hatcher. 11:00 369.3 Student Perspectives on General Learning Philadelphia Col. of Osteo. Med. Compared to Learning Anatomy. A. Notebaert. Univ. of Mississippi Med. Ctr. T 368. FORM AND FUNCTION PLATFORM 11:15 369.4 Dissecting the Development of Clinical U Reasoning in the Gross Anatomy Laboratory. G. Rae, A.C. Platform Karpinski, R. McGoey. LSU Hlth. Sci. Ctr., New Orleans and E Kent State Univ. Col. and Grad. Sch. of Educ. Tue. 10:30 am—San Diego Convention Center, Room 9 11:30 369.5 Comparison of Temporal Variations in Chaired: M. Serrat Ultrasound Training in Four Novice Groups. C. Elzie, A.P. Trace, B. Knapp, F. Toreno, R. Conran, C. Goodmurphy. Developmental Biology/Morphology Eastern Virginia Med. Sch. Evolution/Anthropology 11:45 369.6 Preliminary Results of a National Survey on the Integration of Anatomical Variations in Medical School Megan Holmes is competing as a finalist in the Postdoctoral Curricula. C. Goldberg, D. Royer. Univ. of Colorado Anschutz Platform Presentation Award Med. Campus. 10:30 368.1 The Dynamic Ontogenetic Structure of Mandibular Morphological Integration. M.A. Holmes, M.A. 370. PUBLISHING SUCCESS: HOW TO SUCCEED McNulty, J.C. Mussell, V.B. DeLeon. Sch. of Med., Duke WHEN SUBMITTING TO AAA JOURNALS Univ., LSU Sch. of Vet. Med., Baton Rouge, LSU Hlth. Sci. Ctr., New Orleans and Univ. of Florida. Symposium 10:45 368.2 Comparison of Morphology and Bending Mechanics of Femora in Response to Chronic Exercise (Sponsored by: AAA Journals: Anatomical Sciences in Three Strains of Mice. K.M. Middleton, S.J. Peacock, Education, Developmental Dynamics and The B.R. Coats, J.K. Kirkland, T. Garland; Jr. Univ. of Missouri- Anatomical Record) Columbia, Saint Louis Col. of Pharm., Michigan State Univ. and Tue. 10:30 am—San Diego Convention Center, Room 7B Univ. of California, Riverside. 11:00 368.3 Novel Findings in Rodent Pelvic Limb Anatomy. Chaired: S. Miller H.A. Richbourg, M.J. Martin, M.A. McNulty. LSU Sch. of Professional Development Vet. Med. 11:15 368.4 Variation in Sexual Dimorphism of Mouse Os Career Development Coxae Shape, Volume, and Bone Mineral Density in Response 10:30 Publication Metrics and Evaluators of Success. P. Antin. to Selection for High Voluntary Wheel Running. H. Schutz, Univ. of Arizona. K. Braaten-Fierros, C. Higginbotham, H.A. Jamniczky, 11:00 Ethics in Scientific Publishing. K. Albertine. Univ. E.R. Donovan, T. Garland; Jr. Pacific Lutheran Univ., of Utah. Cumming Sch. of Med., Univ. of Calgary, Canada and Univ. of 11:30 Publishing Educational Research Manuscripts. R. California Riverside. Drake, W. Pawlina. Cleveland Clinic Lerner College 11:30 368.5 Differences in Anterior Cruciate Ligament Fiber of Medicine, Mayo Clinic College of Medicine. Orientation between Digitigrade and Palmigrade Animals. A.A. Ruth, T. Hieironymus, C.O. Lovejoy. Kent State Univ. and Northeast Ohio Med. Univ. 11:45 368.6 Human Achilles and Equine Navicular Apparatus: A Structural and Functional Comparison of Two Premier Enthesis Organs. M.L. Osborn, U. Blas-Machado, E.W. Uhl. Univ. of Georgia Col. of Vet. Med.

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371. NEUROBIOLOGY AWARD HYBRID 373. PARACRINE EFFECTS OF STEM AND PROGENITOR CELLS Hybrid Symposium Symposium Tue. 2:00 pm—San Diego Convention Center, Room 10 Tue. 2:00 pm—San Diego Convention Center, Room 7B Chaired: B. Allman Chaired: T. Ritter Neurobiology Stem Cells/ Regeneration Neurobiology Cell Biology C.J. Herrick Award Lecture in Neuroanatomy featuring 2016 Young Investigator Award Recipient, Hillel Adesnik. Regenerative Medicine (Stem Cells, Tissue Regeneration, Biomaterials) Innocent Edagha is competing as a finalist in the Postdoctoral Platform Presentation Award and Amanda White is competing as 2:00 373.1 Extracellular Vesicles Derived from a finalist in the Langman Graduate Platform Presentation Award Mesenchymal Stem Cells for Treatment of Ocular Surface Injuries. T. Ritter, C. Lal, O. Treacy, G. O’Malley, M. Naughton, 2:00 371.1 New Approaches and Insights Into Cortical S. Naicker, P. Lohan, H.M. Subhash, A. Ryan, G. Fahy, M. Microcircuits. H. Adesnik, A. Mardinly, N. Pegard, I. Leahy, M.D. Griffin, S. Rani. Sch. of Phys., Univ. Hosp., Oldenburg, L. Waller. Univ. of California, Berkeley. Galway, Natl. Univ. of Ireland. 2:30 371.2 Microscopic Evaluation of Synaptic 2:30 The Role of Stem Cell Exhaustion in Aging and Connectivity and Network Formation in Primary Hippocampal Disease: Implications for Stem Cell Therapy. J. Huard. Univ. of Neurons. P. Verstraelen, J.R. Detrez, I. Pintelon, R. Nuydens, Texas Hlth. Sci. Ctr. at Houston. T. Meert, W. De Vos, J-P. Timmermans. Univ. of Antwerp and 3:00 373.2 Exosomes and Their RNA Contents as Janssen Pharmaceut., Beerse, Belgium. Mediators of Therapeutic Regeneration. E. Marban. Cedars- 2:45 371.3 Colonic Dysfunction following Acute Spinal Sinai Heart Inst. Cord Injury: Oxidative Damage to Interstitial Cells of Cajal? A.R. White, G.M. Holmes. Penn State Col. of Med. 3:00 371.4 Cerebellar Neurotoxicity of Artemether- 374. HENRY GRAY DISTINGUISHED EDUCATOR Lumefantrine in Prophylactic, Suppressive and Curative AWARD SYMPOSIA Experimental Malaria Models. I.A. Edagha, G.J. Ekandem, U.M. Ekanemesang. Univ. of Uyo and Obong Univ., Nigeria. Award Lecture 3:15 371.5 Behavioral Evidence of Transient versus Tue. 4:00 pm—San Diego Convention Center, Room 10 Persistent Tinnitus Induced by Loud Noise Exposure in a Novel Rat Model. K. Beh, M. Typlt, G. Sigel, A. Schormans, Education and Teaching D. Stolzberg, B.L. Allman. Univ. of Western Ontario. (561.12) Education 372. THE ROLE OF MICRORNAS IN DEVELOPMENT 4:00 374.1 On the Way to Virtual. R.W. Ogilvie. Med. Univ. of South Carolina and Univ. of South Carolina. Symposium 375. HENRY GRAY SCIENTIFIC AWARD SYMPOSIA Tue. 2:00 pm—San Diego Convention Center, Room 9

Chaired: B.A. Amendt Award Lecture

Developmental Biology/Morphology Tue. 4:30 pm—San Diego Convention Center, Room 10 Bones/Muscle/Connective Tissue 4:30 375.1 The Repairable Brain: An Anatomists View. J.R. Sladek; Jr. Univ. of Colorado, Aurora. 2:00 372.1 MicroRNA Regulation of Craniofacial Development Using New Biotechnology: Inhibition ofmIRr Families in Transgenic Mice and Cells. B.A. Amendt, H. Cao, S. Eliason. Univ. of Iowa and Houston Methodist. 2:30 372.2 MicroRNA Regulation of Early Mammalian Development. R.J. Parchem. Baylor Col. of Med. 3:00 372.3 MicroRNA in Cardiac Arrhythmias. J. Wang, Y. Bai, N. Li, W. Ye, M. Zhang, S.B. Greene, Y. Tao, Y. Chen, X.H.T. Wehrens, J.F. Martin. Baylor Col. of Med. and Tulane Univ.

112 TUESDAY BIOCHEMISTRY Biochemistry and Molecular Biology

376. ASBMB PLENARY LECTURE 379. CHROMATIN REMODELING AND EPIGENETICS

Plenary Symposium

Tue. 8:00 am—San Diego Convention Center, Room 6B Tue. 9:45 am—San Diego Convention Center, Room 1B

8:00 Awardee introduction. Chaired: B. Ren 8:05 376.1 Everything That Matters in Biomedicine Builds on Basic Science. F.S. Collins. OD, NIH. Follow the conversation: #chromatin 9:45 Chair’s Introduction. 377. BERT AND NATALIE VALLEE AWARD IN 9:50 379.1 Reversible RNA Methylation in Gene BIOMEDICAL SCIENCE LECTURE Expression Regulation. C. He. Univ. of Chicago and HHMI. 10:15 Chromatin Remodeler EP400 Deposits H3.3 Award Lecture Into Promoters and Enhancers during Gene Activation. S.K. Pradhan, T. Su, L. Yen, K. Jacquet, J. Cote, S. Kurdistani, M. Tue. 8:55 am—San Diego Convention Center, Room 6B Carey. UCLA and Laval Univ. Cancer Res. Ctr., Quebec. (803.9) 8:55 Awardee introduction. 10:30 379.2 Mechanism and Regulation of the SWI/ 9:00 377.1 DNA Excision Repair Map of the Human SNF Family of ATP-Dependent Chromatin Remodelers. B. Genome at Single Nucleotide Resolution. A. Sancar. Univ. of Bartholomew, P. Sen, S. Kundu, S. Hailu, J. Persinger, A. North Carolina at Chapel Hill Sch. of Med. Hada, Y. Lu, J. Luo, J. Ranish. MD Anderson, Smithville, Univ. T of Pennsylvania and Univ. of Washington. U 378. CHEMICAL BIOLOGY APPROACHES TO 10:55 Epigenetics Impacts Copy Number Heterogeneity and Drug Resistant Gene Selection. J.R. Whetstine, J.C. Black, E UNDERSTAND GLYCAN-RELATED DISEASES S. Mishra, B. Sexton, C. Van Rechem, S. Murphy. MGH Cancer Ctr. and Harvard Med. Sch., Charlestown. (802.10) Symposium 11:10 Structural Basis for Histone H2B Tue. 9:45 am—San Diego Convention Center, Room 1A Deubiquitination by the SAGA DUB Module. M.T. Morgan, M. Haj-Yahya, A.E. Ringel, P. Bandi, A. Brik, C. Wolberger. Chaired: L. Wells Johns Hopkins Med. Inst., Ben Gurion Univ. of the Negev and Follow the conversation: #glyco Technion-Israel Inst. of Technol. (803.14) 11:25 379.3 Structural and Functional Analysis of Histone 9:45 Chair’s Introduction. Chaperones. Y. Gu, S. Bergeron, D. Krzizike, K. Luger. Univ. 9:50 378.1 Activity-Based Glycosidase Profiling:of Colorado at Boulder. Monitoring Glycosphingolipid Metabolism in Health and 11:50 Discussion. Disease. H. Overkleeft. Leiden Univ., Netherlands. 10:15 A New Selective Probe for Visualization and 380. CHEMICAL COMMUNICATION, Identification of O-GlcNAc-Modified Proteins in Cells. P.G. BIOLOGICAL REGULATION Wang, J. Li, J. Wang, L. Wen, S. Li, H. Zhu, C. Ma, X. Li. Georgia State Univ. and Col. of Pharm., Nankai Univ., China. Symposium (616.2) 10:30 378.2 Photocrosslinking Sugars Capture Glycan- Tue. 9:45 am—San Diego Convention Center, Room 6C Dependent Interactions. J. Kohler, S-H. Yu, A.C. Rodriguez. Univ. of Texas Southwestern. Chaired: E. Carlson 10:55 Bioengineering Proteoglycan-Based Matrices Follow the conversation: #chembio for Blood Contacting Applications. M. Lord, C. Chuang, J. Rnjak-Kovacina, B. Cheng, G. Lyons, J. Whitelock. Grad. 9:45 Chair’s Introduction. Sch. of Biomed. Engin., Univ. of New South Wales, Univ. 9:50 380.1 Imaging Cell-Cell Interactions with of Copenhagen, Sydney Med. Sch., Royal Prince Alfred Bioluminescent Probes. J. Prescher. Univ. of California, Irvine. Hosp., Univ. of Sydney and Sydney Head and Neck Cancer 10:15 Design and Development of Chemically Gated Inst. (622.2) Artificial Regulatory Domains. D.T. Cunningham-Bryant. Univ. 11:10 ABO Blood Type Correlates with Survival on of Washington. (809.1) Prostate Cancer Vaccine Therapy. J. Gildersleeve. NCI at 10:30 380.2 Understanding the Regulation of Ferroptosis. Frederick. (1095.5) S. Dixon. Stanford Univ. 11:25 378.3 O-GlcNAc Occurs Cotranslationally to 10:55 Engineered Caspases with Altered Stabilize Nascent Polypeptides. D. Vocadlo, Y. Zhu, T-W. Liu, Specificities Enable Identification of Exosites. J.A. Hardy, M. S. Cecioni, R. Eskandari, W. Zandberg, L. Willems. Simon Hill, D.J. MacPherson, P. Wu, O. Julien, J.A. Wells. Univ. of Fraser Univ., Canada. Massachusetts Amherst and UCSF. (842.10) 11:50 Discussion. 11:10 Determination of HNO-Derived Modifications on the Cardiac Protein Phospholamban. G. Keceli, A. Majumdar, C.N. Thorpe, J.E. Mahaney, N. Paolocci, J.P. Toscano. Johns Hopkins Univ., Edward Via Col. of Osteo. Med., VA and Johns Hopkins Med. Instns. (1092.7)

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11:25 380.4 Metabolic Control via Protein-Protein 11:10 Clonal Evolution of the HER2 L755S Mutation Interaction. M. Burkart. UCSD. Leads to Acquired HER-Targeted Therapy Resistance That 11:50 Discussion. Can Be Reversed by the Irreversible HER1/2 Inhibitor Afatinib. X. Xu, A. Nardone, H. Hu, L. Qin, S. Nanda, T. Mitchell, 381. INTEGRATIVE PROTEOMICS OF M. Shea, L. Heiser, N. Wang, K. Covington, E. Chen, A. PROTEIN COMPLEXES Renwick, T. Wang, C. De Angelis, A. Contreras, C. Gutierrez, S. Fuqua, G. Chamness, C. Shaw, D. Wheeler, J. Gray, S. Symposium Hilsenbeck, M. Rimawi, K. Osborne, R. Schiff. Baylor Col. of Med., Oregon Hlth. & Sci. Univ. and MD Anderson Cancer Ctr., Tue. 9:45 am—San Diego Convention Center, Room 6D Houston. (1107.5) 11:25 382.3 Disrupting Adaptive Bypass Pathways Chaired: A-C. Gingras Activated by Targeted Kinase Inhibitors. G.L. Johnson. Univ. Follow the conversation: #proteomics of North Carolina Sch. of Med. 11:50 Discussion. 9:45 Chair’s Introduction. 9:50 381.1 Integrative Methods for Elucidating the Structure and Function of Cellular Machines. B.T. Chait. 383. NAFLD: METABOLIC INSIGHT INTO THE Rockefeller Univ. ENZYMATIC PLAYERS 10:15 Understanding the Lipid Mediated Oligomerisation in Membrane Proteins. K. Gupta, C. Symposium Robinson. Univ. of Oxford. (819.13) (Sponsored by: ASBMB Minority Affairs Committee) 10:30 381.2 Mapping Dynamic Protein Interaction Landscapes in Saccharomyces cerevisiae Using a Novel Tue. 9:45 am—San Diego Convention Center, Room 6F Whole Network Enrichment Approach. J. Yates, B.D. Stein, Chaired: D.D. Moore D. Calzolari, M. Lavallee-Adam. The Scripps Res. Inst. and Qualcom, San Diego. Follow the conversation: #liver 10:55 Information Extraction from Native Mass 9:45 Chair’s Introduction. Spectra. S. Guan. UCSF. (819.14) 9:50 383.1 Posttranscriptional Regulation of Lipogenesis. 11:10 Dynamic Organellar Maps, a Tool to Study J.D. Horton. Univ of Texas Southwestern Med. Ctr. Proteome-Wide Subcellular Localization Changes. D. Itzhak, 10:15 Palmitoleate Protection against Palmitate- S. Tyanova, J. Cox, M. Mann, G. Borner. Max Planck Inst. of Induced Cholangiocyte Lipoapoptosis Is Sensitive to Pertussis Biochem., Martinsried. (819.3) . S.K. Natarajan, M.A. Walker, M. Toews, J.L. Mott. Univ. 11:25 381.3 Defining Interaction and Structural Dynamics of Nebraska Med. Ctr. (870.5) of Protein Complexes Using Integrated Mass Spectrometry 10:30 383.2 Thioesterase Superfamly Member 2: Metabolic Approaches. L. Huang. Univ. of California, Irvine. Control of Hepatic Fatty Acid Channeling and Pathogenic Role 11:50 Discussion. in Non-alcoholic Fatty Liver Disease. D.E. Cohen. Brigham and Women’s Hosp./Harvard Med. Sch. 382. TARGETED THERAPIES 10:55 Cyclin D1 Regulates Adipose Triglyceride Lipase to Influence Hepatic Lipid Droplet Metabolism and Cell Symposium Proliferation. J. Ploeger, S. Kamarajugadda, D. Mashek, J.H. Tue. 9:45 am—San Diego Convention Center, Room 6E Albrecht. Univ. of Minnesota. (871.1) 11:10 Phosphatidylcholine Transfer Protein Chaired: F. Sicheri Regulates Lipid Droplet Morphology in Experimental Non- alcoholic Steatohepatitis. H.T. Nicholls, J. Song, J. Wu, J.L. Follow the conversation: #cellsignal Hornick, D.E. Cohen. Brigham and Women’s Hosp. and 9:50 382.1 Kinases as Molecular Switches: Catalytic and Harvard Med. Sch. (1128.1) Non-catalytic Functions of BRAF Reveal Novel Insights into 11:25 383.3 Interactions of Branched-Chain Amino Acids Oncogenic Activation. S. Malek, S. Foster, D. Whalen, A. Ozen, and Lipids in Metabolic Disease. C. Newgard. Duke Univ. J. Haling, J. Sudhamsu, I. Yen, J. Yin, G. Hatzivassiliou, 11:50 Discussion. A. Shaw, C. Yu, C. Eigenbrot, G. Manning, N. Skelton, S. Hymowitz. Genentech. 384. DEVELOPING AND SHARING BEST PRACTICES: 10:15 ProKinO: A Unified Resource for Mining the FROM CONCEPTS TO CLASSROOM Cancer Kinome. N. Kannan. Univ. of Georgia. (1107.4) 10:30 382.2 Targeting Tumors Driven by VHL or IDH Symposium Mutations. W. Kaelin. Dana-Farber Cancer Inst. and Brigham and Women’s Hosp., Harvard Med. Sch., HHMI. Tue. 9:45 am—San Diego Convention Center, Room 14A 10:55 Covalent Inhibition of ERK Docking Chaired: J.E. Bell Interactions. T.S. Kaoud, W.H. Johnson, A. Piserchio, N.D. Ebelt, M. Warthaka, M. Cano, R. Sammons, Q. Wang, P. Ren, This session will bring together experienced and early R. Ghose, K.N. Dalby. Univ. of Texas at Austin, Fac. of Pharm., career educators to learn about resources for course materials, Minia Univ., Egypt and City Col. of New York. (856.11) assessment tools and teaching the foundational concepts of biochemistry and molecular biology.

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Invited Speakers: Ann Aguanno, Marymount Manhattan 4:30 Tripartite DNA Lesion Recognition and College, Pam Mertz, St. Mary’s College of Maryland, Jessica Verification by XPC, TFIIH, and XPA in Nucleotide Excision Schrader, Eastern Florida State College, Marilee Benore, Repair. F.M. Golebiowski, C-L. Li, Y. Onishi, N.L. Samara, K. University of Michigan, Dearborn Sugasawa, W. Yang. NIDDK, NIH, Inst. of Molec. Biol., Acad. Sinica, Taipei and Kobe Univ., Japan. (793.2) Follow the conversation: #education 4:45 389.2 Mechanism of Structure-Selective Nucleases. M. Nowotny. Intl. Inst. of Molec. and Cell Biol., Warsaw. 385. THE DO’S AND DON’TS OF DATA ANALYSIS 5:10 Base Excision Repair of Bulky DNA Adducts AND REPORTING Generated by the Antitumor Drug Yatakemycin. E.A. Mullins, R. Shi, Y. Igarashi, B.F. Eichman. Vanderbilt Univ. and Toyama Workshop Prefect. Univ. (791.2) 5:25 Kinetic Mechanism for Binding and Flipping of (Sponsored by: Journal of Biological Chemistry) Damaged Bases by DNA Repair Dealkylases. P. O’Brien. Univ. of Michigan. (574.2) Tue. 12:30 pm—San Diego Convention Center, Room 6A 5:40 389.3 The Replication Machinery Encoded by Chaired: F.P. Guengerich SCCmec and Related Mobile Genetic Elements. P.A. Rice, I. Mir-Sanchis, S. Boyle-Vavra, Y.Z. Pigli. Univ. of Chicago. 6:05 Discussion. 386. ASBMB MERCK AWARD LECTURE 390. STRUCTURAL STUDIES OF COMPLEX SYSTEMS Award Lecture (Sponsored by: Merck & Co., Inc.) Symposium T Tue. 2:00 pm—San Diego Convention Center, Room 6B Tue. 4:00 pm—San Diego Convention Center, Room 6C U 2:00 Awardee introduction. Chaired: TBD E 2:05 386.1 Prospects for Noncoding RNA Discovery in Follow the conversation: #catalysis Bacteria. R.R. Breaker. Yale Univ., HHMI. 4:00 Chair’s Introduction. 387. WILLIAM C. ROSE AWARD LECTURE 4:05 390.1 Snapshots of Benzylsuccinate Synthase: Getting a Handle on Toluene Degradation. C.L. Drennan, M.A. Award Lecture Funk. MIT and HHMI, Cambridge, MA. 4:30 Biochemical Characterization of Two Tue. 2:35 pm—San Diego Convention Center, Room 6B Evolutionary Distant Ten-Eleven Translocation Enzymes and 2:35 Awardee introduction. Their Utility in 5-Methylcytosine Sequencing in the Genomes 2:40 387.1 When Good Ribosomes Go Bad. S.J. Baserga, at Single-Base Resolution. L. Saleh, E. Tamanaha, R. Vaisvila, K.L. McCann, T. Teramoto, J. Zhang, T.M. Tanaka Hall. Yale J.E. Pais, N. Dai, S. Guan, I.R. Corrêa; Jr., Y. Zheng. New Univ. Sch. of Med. and NIEHS, NIH, Research Triangle Park. England Biolabs. (834.2) 4:45 390.2 Learning Drug Design from Nature – The Substrate-Protein and Protein-Protein Interactions of Fatty 388. HERBERT A. SOBER LECTURESHIP Acid and Polyketide Mega-Synthases. S-C. Tsai. Univ. of California, Irvine. Award Lecture 5:10 Protein-Protein Interactions Reduce Ca2+- Tue. 3:10 pm—San Diego Convention Center, Room 6B Requirements for Transglutaminase 2 Mediated Post- translational Modifications ofα -Synuclein. T.N. Zeczycki, J.S. 3:10 Awardee introduction. Viscomi. Brody Sch. of Med. at East Carolina Univ. (1083.16) 3:15 388.1 The Nanodisc Platform for Determining the 5:25 Histone Deacetylase 6: Structure, Mechanism, Structure and Function of Membrane Proteins. S.G. Sligar. and Inhibitor Selectivity. Y. Hai, D. Christianson. Univ. of Univ. of Illinois at Urbana-Champaign. Pennsylvania. (1083.1) 5:40 390.3 Serial Femtosecond Crystallography Opens a 389. STRUCTURAL INSIGHTS INTO DNA REPAIR New Era in Membrane Protein Structural Biology. P. Fromme. Biodesign Inst., Arizona State Univ. Symposium 6:05 Discussion.

Tue. 4:00 pm—San Diego Convention Center, Room 1B 391. NEW FRONTIERS IN PROTEIN Chaired: A. Sfeir QUALITY CONTROL Follow the conversation: #DNA Symposium 4:00 Chair’s Introduction. 4:05 389.1 The Double Edged Sword of DNA Repair. Tue. 4:00 pm—San Diego Convention Center, Room 6D C. Kisker, J. Kuper, C. Braun, A. Elias, G. Michels, A. Chaired: B.A. Schulman Poterszman, J-M. Egly. Univ. of Würzburg, Germany and CNRS, Univ. of Strasbourg, France. Follow the conversation: #proteins 4:00 Chair’s Introduction.

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4:05 391.1 Unconventional Protein Secretion and Protein 4:00 393.1 Functional Lipidomics: From Lipid Timelines Quality Control. Y. Ye, J-G. Lee. NIDDK, NIH. to Regulation of Metabolic Networks. C.S. Ejsing. Univ. of 4:30 ER Protein Quality Control and Lipid Droplets: So. Denmark. Unexpected Functional Connections. J.A. Olzmann. Univ. of California, Berkeley. (816.5) 394. MEMBRANE LIPID REGULATION 4:45 391.2 Rqc2p and 60S Ribosomal Subunits Mediate mRNA-Independent Elongation of Nascent Chains. Symposium O. Brandman. Stanford Univ. 5:10 Elucidating ER-Associated Degradation Tue. 4:00 pm—San Diego Convention Center, Room 6F

Pathway for GABAA Receptors. T. Mu. Case Western Reserve Chaired: J. Ntambi Univ. (598.9) 5:25 The Degradation Requirements for Follow the conversation: #lipids Topologically Distinct Quality Control Substrates in the Yeast 4:00 Chair’s Introduction. Endoplasmic Reticulum. C.J. Guerriero, K.R. Reutter, 4:05 Walter A. Shaw Young Investigator Award in A. Augustine, J.L. Brodsky. Univ. of Pittsburgh. (1063.2) Lipid Research Introduction and Presentation. 5:40 391.3 The E3 Ligase Listerin/Ltn1 Links Ribosome- 4:10 Functional Lipidomics: From Lipid Timelines to Associated Protein Quality Control and Neurodegeneration. Regulation of Metabolic Networks. C.S. Ejsing. Univ. of So. C. Joazeiro. Heidelberg Univ. (ZMBH), Germany and The Denmark. (393.1) Scripps Res. Inst. 4:35 394.3 Dynamic Regulation of the Signaling Lipid 6:05 Discussion. Phosphatidylinositol 3,5-Bisphosphate. L.S. Weisman, N. Jin. Univ. of Michigan. 392. NATURAL PRODUCT BIOSYNTHESIS FOR NEW 5:00 Alterations in Acyl Phosphatidylglycerol DRUG LEADS Levels in ΔpagP, ΔpldB, and Δcls Escherichia coli Leads to Phenotypic Variance. M. Pourmaleki, T.A. Garrett. Vassar Symposium Col., NY. (1133.2) 5:15 394.2 Regulation of Lipid Metabolism by SREBPs. Tue. 4:00 pm—San Diego Convention Center, Room 6E P. Espenshade. Johns Hopkins Univ. Sch. of Med. Chaired: C. Barry 5:40 394.1 Regulation of Yeast Pah1 Phosphatidate Phosphatase in Lipid Synthesis. G.M. Carman. Rutgers Univ. Follow the conversation: #metabolism 6:05 Discussion. 4:00 Chair’s Introduction. 4:05 392.1 Culture Independent Approaches for 395. STRAIGHT FROM THE BENCH: RECENT the Discovery of New Bacterial Metabolites. S.F. Brady. ADVANCES IN PROTEIN ENGINEERING Rockefeller Univ. 4:30 The Biosynthesis of the Indolic Acid Moiety Symposium from the Antibiotic Nosiheptide. E. Badding, S. Booker. Penns State Univ. and HHMI. (1101.2) Tue. 6:30 pm—San Diego Marriott Marquis & Marina 4:45 392.2 Semisynthetic Natural Products for Hotel, San Diego Ballroom A

Antibacterial Drug Discovery. R. Lee. St. Jude Children’s Chaired: M.R. White Res. Hosp. 5:10 The Polyamine Pathway of Leishmania Cochaired: D.L. Schmitt donovani as a Potential Therapeutic Target. S. Roberts, D. Paradis, J. Perdeh, J. Harrelson, B. Jan, P. Yates, B. Ullman. Follow the conversation: #proteins Pacific Univ. and Oregon Hlth. & Sci. Univ.(1103.3) 6:30 Chair’s Introduction. 5:25 Small Fungal Molecule Metabolites Targeting 6:45 395.1 Nearer to Nature: Design and Optimization of Mosquito Midgut FREP1 Block Malaria Transmission. J. Li. Artificial Enzymes. D. Hilvert. ETH Zurich. Univ. of Oklahoma. (627.6) 7:10 Tyro-3, Axl and Mer Chimeric Reporter 5:40 392.3 Nature Bank and Drug Leads for TB. R. Quinn. Systems Shows the Differential Regulations of the TAM Griffith Univ., Australia. Family Receptor Tyrosine Kinases. S.G. Kimani, S. Kumar, S. 6:05 Discussion. Kotenko, R. Birge. Rutgers-New Jersey Med. Sch. (1117.1) 7:20 Novel Cell-Penetrating Peptides Overcome 393. WALTER A. SHAW YOUNG INVESTIGATOR Endosomal Escape and Deliver Protein Cargos Into the Cell. AWARD IN LIPID RESEARCH V. Ngwa, J. Salerno, S. Nowak, C. Chrestensen, J. McMurry. Kennesaw State Univ. (631.2) Award Lecture 7:30 Altered DNA-Binding Specificity Transcription Activator Variant Provides Key to Unlocking Gene Activation (Sponsored by: Avanti Polar Lipids, Inc.) Mechanism. A.N. Meyer, P.A. Weil. Vanderbilt Univ. Med. Ctr. Tue. 4:00 pm—San Diego Convention Center, Room 6F (803.11) 7:40 Atomic Force Microscopy Studies of Presented in the session, “Membrane Lipid Regulation”. Conformational Changes in Proteins and Peptides. Refer to session 394 for additional details N.T. Ploscariu, J. Tomich. Kansas State Univ. (823.3) 4:00 Awardee introduction.

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7:50 Amino Acid Selection during Teicoplanin 7:22 Integrated Analysis of Posttranslational Biosynthesis Can Be Switched by a Point Mutation. T. Kittilä, Modification Proteomes Reveals Interactions and Cell Cycle M.J. Cryle. Max Planck Inst. for Med. Res., Heidelberg and Regulatory Patterns In Toxoplasma gondii. N.C. Silmon de EMBL, Monash Univ., Australia. (841.6) Monerri, R.R. Yakubu, L.M. Weiss, K. Kim. Albert Einstein 8:00 Uptake and Lysosomal Delivery of Col. of Med. (864.13) Recombinant Human Alpha-N-Acetylglucosamine-6-Sulfatase 7:34 Proteome-Wide Structural Analysis of PTM to Mucopolysaccharidosis IIID Fibroblasts. D.R. Moen, D.M. Hotspots Reveals Large Body of Putative Regulatory Elements Wang, X. Zhang, S-h. Kan, J. Wood, S. Ekins, T-F. Chou, P.I. with Predicted Biological Function. H. Dewhurst, M. Torres. Dickson. LA BioMed at Harbor-UCLA and Phoenix Nest Inc. Georgia Tech. (864.24) and Jonah’s Just Begun, Brooklyn. (1070.6) 7:46 Ate1-Mediated Posttranslational Arginylation 8:10 Assessment of CCN2 Independent Modules Is Essential for Stress Response Regulation and Mutagenesis Regenerative Capacity on Osteoarthritis and Further Selecting Suppression. A. Kumar, M.D. Birnbaum, W. Morgan, F. Zhang. the Most Suitable among Them as a Potential Therapeutic Univ. of Miami. (864.2) Drug. T. Abdelkader, E. Aoyama, T. Nishida, T. Hattori, D. 7:58 Investigating the Mechanism by Which the Janune, E.S. Hara, M. Ono, Y. Tabata, T. Kuboki, S. Kubota, Small RNA MtlS Regulates the Mannitol Protein Transporter M. Takigawa. Okayama Univ. and Kyoto Univ. (1070.2) at the Post-translational Level in Vibrio cholerae. E.E. Hansen, 8:20 Enhanced Sample Preparation for Proteomic M.C. Coyle, J.M. Liu. Pomona Col., CA. (595.3) Analysis Utilizing Reversible Biotinylation and Polymer-Based 8:10 Evidence for the Interplay between Post- Protein Engineering. A. Lucas, C. Cummings, A. Russell, J. translational Modifications in Regulating Mycobacterial Minden. Carnegie Mellon Univ. (821.1) Sirtuin Activity. G.S. Yadav, S.K. Ravala, N. Malhotra, P.K. 8:30 Development of “Inside-Out” PEGylated Chakraborti. CSIR-Inst. of Microbial Technol., Chandigarh. Crosslinked Hemoglobin Polymers: A Novel Hemoglobin- (1131.1) Based Oxygen Carrier. K.D. Webster, D. Dahhan, C. Frosti, 8:22 Metabolite-Driven Modifications: Protein T W. Dean, J.B. Chaires, K.W. Olsen. Loyola Univ. Chicago and Acylations Elucidate Substrate Metabolism in Syntrophic U Univ. of Louisville. (825.3) Bacteria. H.H.T. Nguyen, P.H.N. Nguyen, R.P. Gunsalus, M.J. E 8:40 Large-Scale Structure-Based Prediction McInerney, J.A. Loo, R.R. Ogorzalek Loo. UCLA and Univ. of and Identification of Novel Protease Substrates Using Oklahoma. (864.1) Computational Protein Design. M.A. Pethe, A. Rubenstein, 8:34 Investigation into the Role of N-Terminal S.D. Khare. Rutgers and Ctr. for Integrative Proteomics Res., Acetylation of ESAT-6 in Pathogenesis of Mycobacterium Piscataway. (601.2) tuberculosis. J.A. Aguilera, J. Sun. Univ. of Texas at El 8:50 395.3 Controlling the Rate of Energy Transduction Paso. (864.22) in a Protein System through Coupling Pathway Redesign. 8:46 396.2 Posttranslational Modifications in Bacteria- C.J. Wilson. Yale Univ. Host Interaction. F. Shao. Natl. Inst. of Biol. Sci., Beijing. 9:15 Discussion. 9:11 Conclusion.

396. STRAIGHT FROM THE BENCH: 397. ASBMB WOMEN’S BMB SCIENTIST PANEL AND POSTTRANSLATIONAL MODIFICATIONS AND NETWORKING EVENT THE MICROORGANISM RESPONSE Special Event Symposium Tue. 6:30 pm—San Diego Convention Center, Room 6A Tue. 6:30 pm—San Diego Marriott Marquis & Marina Each year, the ASBMB sponsors a session where women Hotel, San Diego Ballroom C scientists reflect on some aspect of their careers or general Chaired: A. Hadjikyriacou issues surrounding women’s participation in science. Networking, mentoring, refreshments, and fun. ASBMB members and Cochaired: A.N. Patananan biochemistry attendees welcome. Follow the conversation: #PTM 6:30 Chair’s Introduction. 398. MEET THE BIOARTIST 6:45 396.1 Arginine Methylation Modulates RNA Biology of African Trypanosomes. L.K. Read. Univ. of Buffalo Sch. Special Event

of Med. Tue. 7:00 pm—Karl Strauss Brewing Company, 1157 7:10 Specificity of Protein Arginine Columbia St., San Diego, CA 92101 Methyltransferases: How Does the Trypanosoma brucei PRMT7 Limit Its Activity to Monomethylation of Its Target Join us for a discussion with the winning scientists behind the Proteins? K. Jain, R.A. Warmack, Y. Feng, E.W. Debler, images of the Annual FASEB BioArt Competition and more at the P. Stavropoulos, G. Blobel, S.G. Clarke. UCLA and The Karl Strauss Brewing Company in downtown San Diego, where Rockefeller Univ. (864.3) the images will be on display throughout EB2016. Refreshments available for purchase.

117 NUTRITION TUESDAY Nutrition

400. USING THE NIH BODY WEIGHT PLANNER FOR Bailey. CDC, Natl. Ctr. for Hlth. Statistics, NIH Office NUTRITION RESEARCH AND COUNSELING of Dietary Supplements and Purdue Univ. 9:00 Monitoring of Nutritional Status in NHANES through (Sponsored by: ILSI NA Technical Committee on Protein) Blood and Urine Biomarkers. C. Pfeiffer. CDC. 9:25 Statistical Approaches for Modeling Usual Intake Using Tue. 7:00 am—San Diego Convention Center, Room 32AB NHANES Data. K. Dodd. NIH, NCI.

Chaired: K.D. Hall 403. INTERNATIONAL FORUM – BRAZIL/ICAN

401. BIOLOGY OF LINEAR GROWTH: A GUIDE FOR International Forum REDUCING CHILDHOOD STUNTING (Supported by International Colleges for the Advancement of Nutrology ) Symposium (Organized and Sponsored by: the International Colleges Tue. 8:00 am—San Diego Convention Center, for the Advancement of Nutrology (ICAN)) Ballroom 20D Tue. 8:30 am—San Diego Convention Center, Room 33BC Chaired: K.P. West, Jr. Cochaired: A. Ferreira Heyn and R. Figueredo Cochaired: K. Kraemer 8:30 Malnutrition in Hospitals. A. Ferreira Heyn, Sociedad Nutrition Across the Lifespan: From Pediatrics to Paraguaya de Nutr., Paraguay Geriatrics 8:45 The Challenges of Obesity’s Pharmacotherapy. 8:00 Introduction: Keeping Biological Plausibility in View D. Ribas Filho, Assn. de Nutrologia, Brazil When Setting Public Health Goals to Reduce 9:00 Collagen Supplement in the Prevention and Treatment Childhood Stunting. K. West, Jr. Johns Hopkins of Degenerative Osteoarthritis. M. Garcez Duarte, Bloomberg Sch. of Publ. Hlth. Curitiba—Paraná, Brazil 8:10 Nutritional, Hormonal and Inflammatory Determinants of 9:15 Infertility and Oxidative Stress. V. Ferreira do Amaral, Bone Development. J. Lui. NICHD, NIH. Univ. Fed. do Paraná, Brazil 8:40 Patterns of Normal Fetal and Postnatal Growth During 9:30 Obesity Comorbidities in Brazilian Children and the 1st 1000 Days. M. Lampl. Emory Univ. Adolescents. C.A. Nogueira-de-Almeida, Univ. de 9:00 Efficacy of Maternal and Child Nutrition Interventions Ribeirão Preto, Brazil to Improve Linear Growth. P. Christian. Johns 9:45 Questions & Answers. Hopkins Univ. 9:20 Linear Growth Beyond the 1st 1000 Days of Life: Is 404. DBC: DIETARY ANTIOXIDANTS There Catch-up Growth? Is it Healthy? A. Stein. Emory Univ. Minisymposium 9:40 Discussion: Implications for Reducing Childhood (Sponsored by: Dietary Bioactive Components RIS) Stunting. K. Kraemer. Sight and Life. Tue. 8:00 am—San Diego Convention Center, Room 29A 402. NUTRITIONAL STATUS MONITORING IN THE Chaired: L. Gu U.S. OVER 45 YEARS IN THE NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY Cochaired: S. Moser (NHANES): UPDATES AND CHALLENGES 8:00 404.1 Protandim Treatment Causes Reversible Nuclear Translocation of Nrf-2 and Activation of the Antioxidant Symposium Response Element. N. Chevreau. LifeVantage Corp., Tue. 8:00 am—San Diego Convention Center, Room 31ABC Sandy, UT. 8:15 404.2 Effects of Acute n-3 Fatty Acid Administration Chaired: N. Ahluwalia on Cardiac Lipid Metabolism and Ca2+ Homeostasis during Ischemia-Reperfusion. H. Zirpoli, N. Quadri, K.M. O’Shea, R. Cochaired: C.J. Boushey Ananthakrishan, M. Abdillahi, R. Rosario, R.J. Deckelbaum, Nutritional Epidemiology R. Ramasamy. Col. of P&S, Columbia Univ. Med. Ctr. and NYU Med. Ctr. 8:00 NHANES in Monitoring Nation’s Health and Nutrition: 8:30 404.3 Sweet Sorghum (Sorghum bicolor) Stalk Setting the Stage. N. Ahluwalia. CDC, Natl. Ctr. for Extract, a Byproduct of Biofuel Production, Ameliorates Hlth. Statistics. Systemic Oxidative Stress in a Murine Model of High-Caloric 8:10 Data Collection, Database Updates, and Findings from Diet-Induced Obesity. L. Reddivari, R. Bhatnagar, A. Massey, the What We Eat in America (WWEIA) Component of J. Vanamala. Penn State and Colorado State Univ. the NHANES. A. Moshfegh. USDA, Beltsville. 8:35 Dietary Supplements: Data Collection, Databases, Total Intakes, and Trends in the U.S. J. Gahche, R.

118 TUESDAY NUTRITION

8:45 404.4 M-A-T (Mucuna, Ashwagandha and Tribulus) 9:30 405.7 Hunger and Satiety Responses to Saturated Enhances Testosterone and Reduces Oxidative Stress: In Vivo Fat-Rich Meals before and after a High PUFA Diet. J.A. Model. V. Juturu, K. Sahin, F. Akdemir, C. Orhan, M. Tuzcu, Cooper, J.L. Stevenson, C.M. Paton. Univ. of Georgia and G. Turk, N. Sahin, I. Yilmaz. OmniActive Hlth. Technols. Inc., Texas Christian Univ. NJ and Firat Univ., Turkey. 9:45 405.8 Spatial Reorganization of Proopiomelanocortin

9:00 404.5 Lycopene Inhibits Amyloid-β25-35-Induced (POMC)-Expressing Neurons in the Arcuate Nucleus of POMC- Apoptosis by Decreasing Intracellular and Mitochondrial Ros EGFP Mice Resistant or Prone to Obesity. D. Tomé, M. Soto, Levels in Human Neuronal SH-SY5Y Cells. S. Hwang, J.W. C. Chaumontet, M. Guillaumin, S. Benoit, G. Fromentin, N. Lim, H. Kim. Col. of Human Ecol., Yonsei Univ., South Korea. Darcel. AgroParisTech, INRA, Univ. Paris-Saclay and Univ. 9:15 404.6 Broccoli (Brassica oleracea) Extract Combats de Lorraine-Nancy. Streptozotocin-Induced Diabetes and Oxidative Stress in Rats. S. Suresh, M.I. Waly, N. Guizani, M.S. Rahman. Col. of Agr. 406. NUTRITION AND GASTROINTESTINAL and Marine Sci., Sultan Qaboos Univ., Oman. FUNCTION: THE MICROBIOME AND BEYOND 9:30 404.7 Redox Modulation of Curcumin Stability: Redox Active Antioxidants Increase Chemical Stability and Minisymposium Biological Activity of Curcumin. G. Zhang, Y. Nimiya, W. Wang, E. Decker. Univ. of Massachusetts Amherst. Tue. 8:00 am—San Diego Convention Center, Room 29D 9:45 404.8 Hydroxytyrosol Is More a More Potent Chaired: K.A. Tappenden Antioxidant Than Tyrosol. J. Rodríguez-Morató, R. de la Torre, J. Blumberg, C-Y.O. Chen. Hosp. del Mar Med. Res. Cochaired: H.D. Holscher Inst., Barcelona, Pompeu Fabra Univ., Spain, Physiopathol. of Obesity and Nutr., Madrid and Tufts Univ., Boston 8:00 406.1 Gastrointestinal Microbial Changes following Whole Grain Barley and Oat Consumption in Healthy Men and T Women. S.V. Thompson, K.S. Swanson, J.A. Novotny, D.J. 405. ENERGY AND MACRONUTRIENT METABOLISM: U Baer, H.D. Holscher. Univ. of Illinois at Urbana-Champaign, E ENERGY BALANCE, MACRONUTRIENTS AND USDA, Beltsville, MD. WEIGHT MANAGEMENT 8:15 406.2 Walnut Consumption Influences the Human Gut Microbiome. H.M. Guetterman, K.S. Swanson, J.A. Minisymposium Novotny, D.J. Baer, H.D. Holscher. Univ. of Illinois at Urbana- (Sponsored by: Nutritional Epidemiology RIS) Champaign and USDA, Beltsville, MD. 8:30 406.3 Utilizing Machine Learning Approaches Tue. 8:00 am—San Diego Convention Center, Room 29C to Understand the Interrelationship of Diet, the Human

Chaired: S.K. Das Gastrointestinal Microbiome, and Health. H. Guetterman, L. Auvil, N. Russell, M. Welge, M. Berry, L. Gatzke, C. Bushell, Cochaired: J.P. Karl H. Holscher. Univ. of Illinois at Urbana-Champaign. 8:45 406.4 Impacts of Age, Snack Food, and Whole and 8:00 405.1 The Portion Control Strategies Trial: A Year- Refined Wheat on the Rat Fecal Microbiome. C. Cotton, K. Long Randomized Controlled Trial on the Impact of Portion Westerman, D. Van Roosebeke, A.V. Kane, A. Tai, J.B. Control on Weight Change. B.J. Rolls, B.L. James, C.E. Blumberg, C-Y.O. Chen, M.S. Obin. Tufts Univ. Friedman Sch. Sanchez, L.S. Roe. Penn State. of Nutr. Sci. and Policy, Tufts Med. Ctr., Tufts Univ. Sch. of Med. 8:15 405.2 A New Commercial Behavioral Weight Loss and USDA at Tufts Univ. Program: Effect of Program Location, Delivery Mode and 9:00 406.5 Impact of Almond Consumption on the Participant Factors on Weight Loss. S.K. Das, C. Brown, J. Composition of the Gastrointestinal Microbiota of Healthy Adult O’ Toole, S.B. Roberts. USDA at Tufts Univ. and Instinct Hlth. Men and Women. A.M. Taylor, K.S. Swanson, J.A. Novotny, Sci. LLC, Weston, MA. D.J. Baer, H.D. Holscher. Univ. of Illinois at Urbana-Champaign 8:30 405.3 Dietary Substitution of Whole Grains for Refined and USDA, Beltsville, MD. Grains Favorably Effects Fiber Intake and Energy Metabolism 9:15 406.6 Trimethylamine-N-Oxide Biomarker Response in Adults. J.P. Karl, M. Meydani, J.B. Barnett, S.M. Vanegas, Is a Function of Dietary Precursor Intake and Gut Microbiota B. Goldin, H. Rasmussen, E. Saltzman, S.S. Jonnalagadda, Composition in Healthy Young Men. C.E. Cho, S. Taesuwan, S.N. Meydani, S.B. Roberts. USDA at Tufts Univ., Tufts Univ. O.V. Malysheva, E. Bender, N.F. Tulchinsky, J. Yan, J.L. Sch. of Med. and General Mills Inc., Minneapolis. Sutter, M.A. Caudill. Cornell Univ. 8:45 405.4 Comparison of Two Administration Forms 9:30 406.7 Differences in the Infant Gut Microbiota Related of a Highly Viscous Fibre Blend on Appetite and Glycemic to the Fatty Acid Composition of Human Milk: Results from Response in Healthy Individuals. F. Au-Yeung, E. Jovanovski, the GEHM Cohort. D.H. Taft, K.A. Dingess, C.J. Valentine, H. Ho, A. Zurbau, A.L. Jenkins, V. Vuksan. St. Michael’s Hosp. B.S. Davidson, N.J. Ollberding, D.V. Ward, J.T. Brenna, R.J. and Univ. of Toronto. McMahon, A.L. Morrow. Cincinnati Children’s Hosp. and Med. 9:00 405.5 FTO Genotype, Dietary Protein Intake and Ctr., Mead Johnson Nutr., Glenview, IL, Univ. of Massachusetts Body Weight in a Population of Young Adults. J. Jamnik, D. Med. Sch. and Cornell Univ. Merritt, A. El-Sohemy. Univ. of Toronto. 9:45 406.8 Formula Milk Alters Microbial Diversity in 9:15 405.6 Predicting Initial Lipid Release from Masticated Porcine Colon and Impacts Immune Response. M.K. Saraf, Tree Nuts Using Mathematical Modelling. T. Grassby, Y. Shen, A.K. Bowlin, S.V. Chintapalli, K. Shankar, T. LeRoith, M.J. L. Wagner, S. Beckett, W. Hall, S. Berry. King’s Col. London. Ronis, T.M. Badger, L. Yeruva. Arkansas Children’s Nutr. Ctr., Univ. of Arkansas for Med. Sci., VA-MD Col. of Vet. Med. and LSU Hlth. Sci. Ctr., New Orleans.

119 NUTRITION TUESDAY

407. NUTRITION ACROSS THE LIFESPAN: 408. COMMUNITY AND PUBLIC HEALTH NUTRITION: NUTRITION, NEUROBIOLOGY, MOOD AND HEALTH DISPARITIES AND PROMOTING BEHAVIOR HEALTH IN DIVERSE POPULATIONS

Minisymposium Minisymposium (Sponsored by: Aging and Chronic Disease RIS) (Sponsored by: Community and Public Health Nutrition RIS) (Cosponsored by: Nutrition Translation RIS and Obesity RIS ) Tue. 8:00 am—San Diego Convention Center, Room 30B

Tue. 8:00 am—San Diego Convention Center, Room 30A Chaired: L. Sibeko

Chaired: N.A. Khan Cochaired: M.D. Olfert

Cochaired: C. Castaneda-Sceppa 8:00 408.1 The Effects of Experimentally Manipulating Social Status on Acute Eating Behavior: A Randomized, 8:00 407.1 EGCG Decreases Mortality in a Dose- Crossover Pilot Study. M. Cardel, S.L. Johnson, J. Beck, E. Dependent Fashion but Does Not Improve Cognition in Aged Dhurandhar, A. Dulin-Keita, A. Tomczik, G. Pavela, T. Huo, Mice. B.D. Pence, T.K. Bhattacharya, J.L. Rytych, P. Park, J.M. D. Janicke, K. Muller, J.C. Peters, J.O. Hill, D.B. Allison. Univ. Allen, Y. Sun, R.H. McCusker, K.W. Kelley, R.W. Johnson, of Florida, Univ. of Colorado Denver, Aurora, Colorado State J.S. Rhodes, J.A. Woods. Univ. of Illinois Urbana-Champaign. Univ., Texas Tech Univ., Brown Univ. and Univ. of Alabama 8:15 407.2 Early Exposure to High-Sucrose Diet Triggers at Birmingham. Hippocampal Endoplasmic Reticulum-Stress in Young Rats. 8:15 408.2 The Relationship between Weight Loss Advice A.M.A. Paes, B.A.S. Pinto, T.M. Melo, K.F.T. Flister, L.M. from Friends on Self-Perception of Weight and Eating Habits. França, L.Y. Tanaka, F.R.M. Laurindo. Fed. Univ. of Maranhão T. Thibodeau, I. van Woerden, P. Ohri-Vachaspati, J. Huberty, and Univ. of São Paulo, Brazil. M. Bruening. Arizona State Univ. 8:30 407.3 DHA Status Is Related to Prefrontal Cortex- 8:30 408.3 Promotion of Drinking Water among Latino Mediated Impulse Control in Adolescents. V.L. Darcey, Immigrant Youth. N. Barrett, U. Colón-Ramos, I. Rivera, W.D. S. El Damaty, E.J. Rose, D.H. Fishbein, J.W. VanMeter. Evans, M. Edberg. George Washington Univ. Milken Inst. Sch. Georgetown Univ. and Penn State of Publ. Hlth. and Rivera Group Inc., Washington, DC. 8:45 407.4 Blood Cholesterol in Late-Life and Cognitive 8:45 408.4 Nutrient Intake among Overweight/Obese Decline: A Longitudinal Study of the Chinese Elderly. C. Ma, Z. Hispanic Women Based on Type 2 Diabetes Diagnosis Yin, J. Luo, P. Zhu, X. Shi, X. Gao. Penn State, Chinese Ctr. Status. M. Arias-Gastelum, N.M. Lindberg, A.G. Rosales, M. for Dis. Control and Prevent., Beijing. Petrovic, E.S. LeBlanc, V.J. Stevens, T.J. Kapka, R.T. Meenan, 9:00 407.5 Homocysteine Concentration Correlates with S. Vega-López. Arizona State Univ., Kaiser Permanente Ctr. Baseline Clinical Status and Predicts Outcomes in a Large, for Hlth. Res., Portland and Virginia Garcia Mem. Hlth. Ctr., Early Parkinson’s Disease Cohort (DATATOP). R. Green, Hillsboro, OR. Y. Yelpaala, S. Catalya, P. Auinger, C. Christine. Univ. of 9:00 408.5 Barriers and Facilitators to Healthy Eating: A California Davis, Sacramento, Univ. of Rochester and UCSF. Transnational Comparison of Central American Communities 9:15 407.6 Beneficial Interactions between B Vitamins in a Socio-ecological Framework. M. Fuster, U. Colón-Ramos. and Omega-3 Fatty Acids in the Prevention of Brain Atrophy CUNY-Brooklyn Col. and George Washington Univ. Milken Inst. and of Cognitive Decline in Early Stage Alzheimer’s Disease. Sch. of Publ. Hlth. D. Smith, H. Refsum, A. Oulhaj, C.A. de Jager, F. Jerneren. 9:15 408.6 Associations between Dysfunctional Eating Univ. of Oxford, Univ. of Oslo, United Arab Emirates Univ. and Behaviors and Cardiovascular Risk among Latinos. A.A. Univ. of Cape Town. Lopez-Cepero, C.M. Frisard, S.C. Lemon, M.C. Rosal. Univ. 9:30 407.7 Gray Matter Thickness of Inferior Frontal of Massachusetts Med. Sch. Cortex Mediates the Relationship between Phosphatidylcholine 9:30 408.7 Secular Trends in Regional Differences in and Executive Functions in Healthy, Older Adults. M.K. Biomarkers of Dietary Exposure and Inflammation among Zamroziewicz, T. Das, S.L. Pereira, A.K. Barbey. Univ. of American Adults: NHANES III, 1988-1994 to C-NHANES 1999- Illinois Urbana-Champaign and Abbott Nutr., Columbus, OH. 2010. A.K. Kant, B.I. Graubard. Queens Col. of CUNY and 9:45 407.8 Changes in Eating Behaviors Are Associated NCI, NIH. with Intentional Weight Loss following Intervention in Older 9:45 408.8 Racial/Ethnic and Income Disparities in Women. A.C. Berg, K.B. Johnson, C.R. Straight, R.M. the Sodium Content of Packaged Food Purchases by U.S. Acitelli, P.J. O’Connor, E.M. Evans, M.A. Johnson. Univ. Households in the Past 15 Years. J.M. Poti, E. Dunford, B.M. of Georgia. Popkin. Univ. of North Carolina at Chapel Hill.

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409. POLICY: INNOVATIONS IN MONITORING 410. NUTRITION EDUCATION: NUTRITION HEALTH AND NUTRITION STATUS EDUCATION AND BEHAVIOR CHANGE

Minisymposium Minisymposium (Sponsored by: Public Policy Committee) (Sponsored by: Nutrition Education and Behavioral Science RIS) Tue. 8:00 am—San Diego Convention Center, Room 30C Tue. 8:00 am—San Diego Convention Center, Room 30D Chaired: A.H. Lichtenstein Chaired: J. Banna Cochaired: S.D. Ohlhorst Cochaired: H. Muzaffar Science Policy 8:00 410.1 Effect of Nutrition Education on Weight Gain 8:00 409.1 Adherence Monitoring Tool for Controlled Prevention in Adult Women: Findings from a Randomized Feeding Studies. D.J. Burnett, J.M. Peerson, B. Miller, L.C. Controlled Trial. C.J. Metzgar, S.M. Nickols-Richardson. Welch, M.G. Witbracht, S. Krishnan, N.L. Keim. USDA and Univ. of Illinois at Urbana-Champaign. Univ. of California, Davis. 8:15 410.2 Effect of Nutrition Education with an Emphasis 8:15 409.2 Inter-finger Variability and Other Influencing on Consumption of Iron-Rich Foods on Hemoglobin Levels of Factors for Using Reflectance Spectroscopy for Skin Pregnant Women in Ghana. G. Otoo, Y. Adam. Univ. of Ghana. Carotenoid Detection. L.D. Whigham, A.H. Redelfs. Paso del 8:30 410.3 Diet Quality of a Pregnant Primarily African Norte Inst. for Healthy Living, El Paso. American Cohort Residing in the Mississippi Delta: Delta 8:30 409.3 Skin Carotenoids as Biomarker for Vegetable Healthy Sprouts. M.H. Goodman, J.L. Thomson, L.M. and Fruit Intake: Validation of the Reflection-Spectroscopy Tussing-Humphreys. USDA, Stoneville, MS and Univ. of T Based “Veggie Meter”. I.V. Ermakov, L.D. Whigham, A.H. Illinois at Chicago. U Redelfs, L. Jahns, J. Stookey, P.S. Bernstein, W. Gellermann. 8:45 410.4 Online and In-Person Nutrition Education E Image Technols. Corp., Salt Lake City, Paso del Norte Inst. Reduces Sodium Intake: A Randomized Trial to Assess for Hlth. Living, El Paso, USDA, Grand Forks, San Francisco Knowledge, Self-Efficacy and Behaviors in WIC Participants. Dept. of Publ. Hlth. and Univ. of Utah. L. Au, S. Whaley, N.J. Rosen, M. Meza, L.D. Ritchie. Univ. 8:45 409.4 Understanding the Impacts of State Laws on of California, Berkeley, Publ. Hlth. Fndn. Enterprises WIC, Child Nutrition Programs: An Argument for Employing New Irwindale, CA and Informing Change, Berkeley. Methodologies. A. Field, B. Fiese. Univ. of Illinois, Urbana. 9:00 410.5 Social Media Usage Pattern among 9:00 409.5 Utilizing Smartphone Technology to Monitor Supplemental Nutrition Assistance Program Education Eligible Improvements in the Healthiness of the Food Supply. Individuals in Georgia. A. White, R. Hagues, A. Childers, J.S. E. Dunford, M. Crino, B. Neal. Univ. of North Carolina at Lee, B. Olubajo, J. Phua. Univ. of Georgia and Samford Univ. Chapel Hill and George Inst. for Global Hlth., Sydney. 9:15 410.6 The Role of Grit in Body Weight Regulation 9:15 409.6 Diet Quality, Measured Using the Healthy Over Time. C.J. Metzgar, S.M. Nickols-Richardson. Univ. of Eating Index-2010, Varies by Source Where Food Is Obtained Illinois at Urbana-Champaign. in the United States. M. Wilson, S. Krebs-Smith, J. Reedy, M. 9:30 410.7 Dietary Intake and Diet Quality of Low-Income Story, P. Britten, W. Juan. NCI, NIH, Duke Global Hlth. Inst., Adult Georgians Participating in Supplemental Nutrition USDA, Alexandria, VA and FDA, College Park, MD. Assistance Program Education. J.S. Lee, J. Hibbs, J. Moore, 9:30 409.7 Cereal Foods Consumption Trends and B. Olubajo, A. White, C. Bailey, M. Lewis. Univ. of Georgia. Factors Associated with Changing Intake, among Western 9:45 410.8 What Can Nutrition Education Offer to Improve Australian Adults, 1995 to 2012. C.M. Pollard, C. Pulker, X. Dietary Sodium Restriction Interventions for Heart Failure Meng, F. Denham, V. Solah, J.A. Scott, D.A. Kerr. Sch. of Patients? M. Burgermaster, R. Rudel, J. Wessler, D.S. Seres. Publ. Hlth., Curtin Univ., Dept. of Hlth. in Western Australia and Columbia Univ. Med. Ctr., New York Presbyterian Hosp. Flinders Univ., Australia. 9:45 409.8 Application of the Evidence Review Cycle Model to Review Food and Health Evidence to Inform Canadian 411. OBESITY RIS ANNUAL BUSINESS MEETING: Dietary Guidance Decision-Making. H. Lowell, A. Ellis, C.K. HOT TOPIC DISCUSSION: GUT MICROBIOTA, Colapinto. Hlth. Canada, Ottawa. CAUSAL INFERENCE, AND OBESITY

RIS Forum (Sponsored by: Obesity RIS)

Tue. 9:30 am—San Diego Convention Center, Room 32AB

Are You Tweeting about EB 2016? Chaired: D.B. Allison To Tweet use #expbio Be sure to follow EB on Facebook and Twitter.

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412. NUTRITION, MICRORNAS AND HUMAN HEALTH 414. AMID CONTROVERSY AND CAVEATS: THE FUTURE OF THE POSTDOC Symposium Symposium Tue. 10:30 am—San Diego Convention Center, Ballroom 20D Tue. 10:30 am—San Diego Convention Center, Room 33BC

Chaired: J. Zempleni Chaired: L.P. Smith Taillie

Cochaired: S.A. Ross Cochaired: Y. Segar

Cellular and Molecular Nutrition Education 10:30 Biological Activities of Dietary microRNAs. J. Zempleni. Career Development Univ. of Nebraska-Lincoln. 11:00 Effects of Dietary Compounds on the Expression of Education Genes Coding for Endogenous microRNAs. S. Ross. 10:30 Priorities and Pitfalls for Powerful Postdoc Experiences. NCI, NIH. S. Chang. Univ. of Texas MD Anderson Cancer Ctr. 11:30 Bioinformatics Tools and Databases for the Analysis 10:50 The Future of the Postdoc: Thinking Outside the Training of Nutrition, MicroRNAs and Human Health. J. Cui. Box. R. Wheeler. The Scripps Res. Inst. Univ. of Nebraska-Lincoln. 11:10 Mind Your P’s and hD’s: What Else Can I Do With My 12:00 Regulation of Immune Function in Adipose Tissue by Degree? K. Gibbs, Jr. NIGMS, NIH. microRNAs. B. Zhou. UConn Hlth. 11:30 Preparing for a Career in Industry: The First Job Post- PhD. D. Bolster. PepsiCo. 413. PROGRAM EFFECTIVENESS FOR ADDRESSING UNDERNUTRITION DURING THE 415. ENERGY AND MACRONUTRIENT METABOLISM: FIRST 1000 DAYS PROTEIN INTAKE AND HEALTH IMPLICATIONS

Symposium Minisymposium

Tue. 10:30 am—San Diego Convention Center, Room (Sponsored by: Energy & Macronutrient Metabolism RIS) 31ABC Tue. 10:30 am—San Diego Convention Center, Room 33A Chaired: M.L. Deitchler Chaired: A. Thalacker-Mercer Cochaired: Z. Maalouf-Manasseh Cochaired: M. Drummond Nutrition Across the Lifespan: From Pediatrics to Geriatrics 10:30 415.1 The Relationship between Dietary Protein Intake Distribution and Lean Mass Loss in Free-Living Older 10:30 Effectiveness of Home-fortification Approaches in the Adults: Effect of Sex and Total Protein Intake. S. Farsijani, First 1000 days for Preventing Maternal and Child J.A. Morais, H. Payette, P. Gaudreau, B. Shatenstein, K. Undernutrition: The Rang-Din Nutrition Study in Gray-Donald, S. Chevalier. McGill Univ., Univ. of Sherbrooke, Bangladesh. K. Dewey. Univ. of California, Davis. CHUMRC, Montreal and Univ. of Montreal. 10:50 The Impact of a Food-Assisted Integrated Health and 10:45 415.2 Whey and Pea Protein Influence Energy Nutrition Program in Burundi on Maternal and Child Metabolism and Appetite Response to a Greater Extent Than Nutrition and on Child Development Outcomes. Beef Protein. B.L. Neumann, L. Cambias, C. Mitchell, E. M. Ruel. Intl. Food Policy Res. Inst. Silva, J.I. Baum. Univ. of Arkansas. 11:10 The Impact of a Food-Assisted Integrated Health and 11:00 415.3 The Effects of Reduced Protein-Nutrition Bars Nutrition Program in Guatemala on Maternal and with Enhanced Leucine Content on Ratings of Fullness in Child Nutrition and on Child Development Outcomes. Healthy Women. D. Bolster, M. Rahn, A. Kamil, L. Toth, H. D. Olney. Intl. Food Policy Res. Inst. Leidy, M. Blaze, M. Nunez, E. Guo, J. Wang, L. Harkness. 11:30 Differential Pathways for Linear, Ponderal and Head PepsiCo, Barrington, IL and New Haven, CT and Univ. Growth in Fetal Life: Implications for Healthy Child of Missouri-Columbia. Growth Programs in Low-income Settings. P. Ashorn. 11:15 415.4 The Effect of Dietary Protein on Bone during Univ. of Tampere. Weight Loss: A Meta-analysis and Systematic Review. C.S. 11:50 Moving from Measured Effects to Human Behavior, Costs Wright, J. Li, W.W. Campbell. Purdue Univ. and Policy Choices: Identifying Innovative and Cost- 11:30 415.5 Effects of Increased Dietary Protein on Daily effective Products and Delivery Platforms to Address Appetite Control, Satiety, and Free-Living Ad Libitum Food Undernutrition. S. Vosti. Univ. of California, Davis. Intake during Acute Energy Restriction in Healthy, Overweight Women. J.A. Gwin. Univ. of Missouri-Columbia. 11:45 415.6 Higher Protein Intake Improves Sleep and Blood Pressure, and Influences the Relation between Changes in Blood Pressure and Sleep during Energy Restriction in Middle-Aged Overweight and Obese Adults. J. Zhou, J.E. Kim, W.W. Campbell. Purdue Univ.

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12:00 415.7 Protein Oxidation as a Relevant Factor 417. NUTRITIONAL EPIDEMIOLOGY: NUTRITION Determining Protein Status in Humans. G. Reckman, M. AND CHRONIC DISEASE EPIDEMIOLOGY Priebe, R. Vonk. Univ. Med. Ctr. Groningen, Netherlands. 12:15 415.8 General Control Nonderepressible 2 Kinase Minisymposium Regulates Body Composition and Antioxidant Defenses during Dietary Methionine Restriction. A.P. Pettit, A. Bargoud, E.T. (Sponsored by: Nutritional Epidemiology RIS) Mirek, T.G. Anthony. Rutgers Univ.-New Brunswick. Tue. 10:30 am—San Diego Convention Center, Room 29B

416. DBC: PROBIOTICS, GUT MICROBIOTA, AND Chaired: S. Sahni GUT HEALTH Cochaired: N. Ollberding

Minisymposium 10:30 417.1 Impact of Body Mass Index and Metabolic Health Status on All-Cause Mortality Risk among Older Adults. (Sponsored by: Dietary Bioactive Components RIS) F.W. Cheng, X. Gao, D.C. Mitchell, C. Wood, C. Still, G.L.

Tue. 10:30 am—San Diego Convention Center, Room 29A Jensen. Penn State and Geisinger Obesity Inst., Danville, PA. 10:45 417.2 Higher Adherence to the Mediterranean Diet 10:30 416.1 Dietary Small RNA Modulation of Gut Score, but Not Other Diet Quality Scores, Is Associated with a Microbiota Composition: In Silico and In Vitro Analyses. H. Favorable Longitudinal Cardiometabolic Profile in the Boston Huang, C. Davis, L. Yu, T.T.Y. Wang. USDA, Beltsville, MD, Puerto Rican Health Study. J. Mattei, M. Sotos-Prieto, S.E. ODS, NIH and Univ. of Maryland College Park. Noel, K.L. Tucker. Harvard T.H. Chan Sch. of Publ. Hlth. and 10:45 416.2 High-Calorie Diet Induced Chronic Colonic Univ. of Massachusetts Lowell. Inflammation: A Human-Relevant Porcine Model to Assess 11:00 417.3 Vitamin K Consumption Is Associated with Left Whole Food Approach to Reduce Colon Cancer Risk. J. Ventricular Structure and Function in Adolescents. J. Nguyen, T Vanamala, A. Sido, E. Eriksson, S.W. Kim, V. Bhat, S. M.E. Fain, C.L. Davis, G.K. Kapuku, B. Gutin, N.K. Pollock. U Radhakrishnan, L. Reddivari. Penn State, Penn State Col. of Georgia Regents Univ., Med. Col. of Georgia, Georgia Prevent. E Med., Lund Univ., Sweden, North Carolina State Univ., Agilent Inst. and Univ. of North Carolina at Chapel Hill. Technols., Wilmington, DE and Res. Diets, New Brunswick, NJ. 11:15 417.4 Correlation of Adolescent Caffeine Intake with 11:00 416.3 Soluble Mediators from lLactobacillus Blood Pressure in Adolescence and Adulthood. E. Estrada, rhamnosus GG Reduce Intestinal Permeability and Bacterial E.M. Urbina, S.R. Daniels, J.G. Woo. Univ. of California, Davis, Translocation in a Rat Model of Short Bowel Syndrome Model. Cincinnati Children’s Hosp. Med. Ctr. and Univ. of Colorado J. Wu, L. Qian, Y. Zhong, G. Gross, E. van Tol, T. Lambers, Sch. of Med. W. Cai. Xin Hua Hosp. Affil. to Shanghai Jiaotong Univ. Sch. 11:30 417.5 Breastfeeding as a Potential Factor Related of Med., Shanghai Inst. for Pediat. Res. and Mead Johnson to Preservation of Insulin Secretion in Youth with Recently Pediat. Nutr. Inst.,Shanghai and Nijmegen. Diagnosed Type 2 Diabetes: The Search Nutrition Ancillary 11:15 416.4 Expression of MicroRNA-148a and Its Target Study. T.L. Crume, J. Crandell, A.P. Lamichhane, D. Dabelea, Gene EPAS1 (Endothelial Pas Domain-Containing Protein J.A. Tooze, A. Liese, L. Dolan, J.M. Lawrence, C. Pihoker, E.J. 1) in Intestinal Cells in Response to Bifidobacterium bifidum Mayer-Davis. Colorado Sch. of Publ. Hlth., Univ. of Colorado MIMBb75. A. Taibi, E.M. Comelli, N. Singh, J. Chen, S. Anschutz Med. Campus, Univ. of North Carolina at Chapel Hill, Guglielmetti. Univ. of Toronto, Ctr. for Child Nutr. and Hlth., LEAD Ctr., Aurora, Wake Forest Univ., Univ. of South Carolina, Toronto and Univ. of Milan. Cincinnati Children’s Hosp. Med. Ctr., Kaiser Permanente So. 11:30 416.5 The Impact of Limonin on Gut Microbiota. California, Pasadena and Seattle Children’s Hosp. M. Gu, J. Sun, C. Qi, K.X. Cai, T. Goulette, Y.M. Song, M.X. 11:45 417.6 Nut Intake, Prospective Weight Change, and You, D. Sela, H. Xiao. Univ. of Massachusetts Amherst and Obesity Risk: The Adventist Health Study-2. S.S. El-Amari, J.I. Jiangnan Univ., China. Lloren, J. Sabate. Loma Linda Univ. Sch. of Publ. Hlth. 11:45 416.6 Impact of Cranberry on Gut Microbiota in a 12:00 417.7 Dietary Carbohydrate Intake, Glycemic Index Colon Carcinogenesis Mouse Model. X. Cai, J. Sun, C. Qi, M. and Glycemic Load in Relation to Adiposity-Related Cancer Gu, T. Goulette, X. Wu, M. Song, X. You, D. Sela, C. Neto, H. Risk: Results from the Framingham Offspring Cohort (1991- Xiao. Univ. of Massachusetts Amherst, Jiangnan Univ., China 2013). N. Makarem, Y. Lin, E.V. Bandera, P. Jacques, and Univ. of Massachusetts Dartmouth. N. Parekh. Col. of Publ. Hlth., NYU, Rutgers Cancer Inst. of 12:00 416.7 Dietary Enrichment with Blueberry and/or NJ, Rutgers Univ. and USDA at Tufts Univ. Probiotics Does Not Alter Blood Pressure Variability Compared 12:15 417.8 A Review and Meta-analysis of Prospective to Control Diet in Hypertensive Rats. C. Blanton, Z. He, K.T. Studies of Red and Processed Meat, Meat Cooking Methods, Gottschall-Pass, M.I. Sweeney. Idaho State Univ. and Univ. of Heme Iron, Heterocyclic Amines and Prostate Cancer. L.C. Prince Edward Island, Canada. Bylsma, D. Alexander. EpidStat Inst., Ann Arbor. 12:15 416.8 Dietary Red Raspberries Supplementation Ameliorates Dextran Sulfate Sodium-Induced Acute Colitis. S. Bibi, Y. Kang, M. Du, Y. Xue, M-J. Zhu. Washington State Univ. Pullman.

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418. ENERGY AND MACRONUTRIENT METABOLISM: 419. INTERVENTIONS FOR THE TREATMENT DIET AND/OR EXERCISE REGULATION OF AND PREVENTION OF NUTRITION- FOOD INTAKE RELATED DISEASES

Minisymposium Minisymposium (Sponsored by: Energy & Macronutrient Metabolism RIS) (Sponsored by: Medical Nutrition Council)

(Cosponsored by: Obesity RIS) Tue. 10:30 am—San Diego Convention Center, Room 29D

Tue. 10:30 am—San Diego Convention Center, Room 29C Chaired: C.W. Bales

Chaired: N. Bellissimo 10:30 419.1 Influence of Daily and per Meal Protein Intakes on Function and Body Composition in Frail, Obese Older Cochaired: B. Burton-Freeman Adults Undergoing Weight Reduction. K.N. Porter Starr, 10:30 418.1 Mechanisms of Appetite Suppression after High M.C. Orenduff, S.R. McDonald, C.F. Pieper, H.C. Mulder, K. Intensity Exercise in Lean and Obese Boys. S. Hunschede, A. Maloney, C.W. Bales. Duke Univ. Med. Ctr. and Durham VA Schwartz, R. Kubant, R. Akilen, S. Thomas, G.H. Anderson. Med. Ctr. Univ. of Toronto Fac. of Med. and Fac. of Kinesiol. 10:45 419.2 Multipronged Therapeutic Mechanisms of 10:45 418.2 The Relative Reinforcing Value of Snack Chinese Herbal Medicine QHD in the Treatment of NAFLD. Q. Foods in Response to Consumption of Sugar- or Non-nutritive- Feng, W. Liu, S.S. Baker, H. Li, S. Meng, Y. Tang, S. Tang, Sweetened Beverages. S.L. Casperson, L. Johnson, J.N. L. Guan, M. Tsompana, R. Kozielski, R. Zhu, R.D. Baker, J. Roemmich. USDA, Grand Forks. Peng, G. Ji, P. Liu, Y. Hu, L. Zhu. Shanghai Univ. of Traditional 11:00 418.3 Changes in Hunger and Fullness in Relation to Chinese Med., SUNY Buffalo, Ningbo No.2 Hosp. and Tongji Gut Peptides Before and After 8 Weeks of Alternate Day Fasting. Univ., China. K.A. Varady, K.K. Hoddy, C.M. Kroeger, J.F. Trepanowski, S. 11:00 419.3 Acute Orange Pomace Consumption Bhutani, A. Barnosky. Univ. of Illinois at Chicago. Diminishes Postprandial Glycemic Responses in Healthy Men. 11:15 418.4 FTO Genotype and Weight Status among C-Y.O. Chen, J.B. Blumberg. USDA at Tufts Univ. Children: Assessing Mediating and Independent Effects of 11:15 419.4 Prebiotic Diet Modulates Gut Microbial Child Eating Behaviors. J.A. Emond, A. Tovar, R. Lansigan, Z. Composition and Metabolic Functions in Metabolic Syndrome Li, D. Gilbert-Diamond. Geisel Sch. of Med. at Dartmouth and Patients: Follow-Up of a Double Blind, Controlled, Crossover Univ. of Rhode Island. Intervention. B. Upadhyaya, R. Juenemann, L. McCormack, 11:30 418.5 Impact of Imposed Exercise on Children’s Ad A.R. Fardin-Kia, J. Clapper, S. Nichenametla, B. Specker, M. Libitum Energy Intake. S.N. Fearnbach, T.D. Masterson, H.A. Dey. South Dakota State Univ. and USDA, College Park, MD. Schlechter, D.S. Downs, D. Thivel, K.L. Keller. Penn State 11:30 419.5 Parents of Preschoolers: Weight-Related and Clermont Auvergne Univ., France Cognitions and Behaviors. J.T. Martin-Biggers, V. Quick, G. 11:45 418.6 Menstrual Cycle Hormones, Food Intake, and Povis-Alleman, N. Hongu, J. Worobey, C. Byrd-Bredbenner. Cravings. S. Krishnan, R. Tryon, L.C. Welch, W.F. Horn, N.L. Rutgers Univ. and Univ. of Arizona. Keim. Univ. of California, Davis and USDA, Davis. 11:45 419.6 Prospective Association of Fasting Blood 12:00 418.7 Effects of Dietary Protein and Fiber at Breakfast Glucose Levels with Risk of Incident Stroke among Hypertensive on Postprandial Appetite, Neural Responses to Visual Food Patients in China: Impact of Folic-Acid Intervention. R. Xu, X. Stimuli, and Ad Libitum Energy Intake at Lunch in Overweight Kong, B. Xu, M. Ji, Y. Zhang, B. Wang, F.F. Hou, J. Ge, Y. Huo, Adults. R.D. Sayer, A. Amankwaah, G. Tamer; Jr, N. Chen, J. Li. River Hill H.S., Clarksville, MD, Peking Univ. First Hosp., A. Wright, J. Tregellas, M. Cornier, D. Kareken, T. Talavage, Beijing, Zhongshan Hosp., Fudan Univ., China, Nanfang Hosp., M. McCrory, W. Campbell. Weldon Sch. of Biomed. Engin., So. Med. Univ., China. Purdue Univ., Univ. of Colorado Sch. of Med., Anschutz Med. 12:00 419.7 Camel Milk and Nigella sativa Oil Improve Campus, Indiana Univ. Sch. of Med. and Georgia State Univ. Liver Biomarkers among Children with Viral Hepatitis. M.S. 12:15 418.8 Comparison of the Effects of a Sweetened Ismail, A.E-S. El- Adawi, O.M. Nassar. Menoufia Univ., Egypt Beverage Intervention on Self-Selected Food Intake. A.M. and Univ. of Dammam, Saudi Arabia. Widaman, K.L. Stanhope, G.X. Chen, V.M. Medici, A.A. 12:15 419.8 Three Doses of Vitamin D on Insulin Resistance Bremer, V. Lee, M.V. Nunez, P.J. Havel, N.L. Keim. Univ. of and Osteocalcin Measures in Older Women. L.C. Pop, S.H. California, Davis and USDA, Davis. Schneider, D. Sukumar, Y. Schlussel, S.A. Shapses. Rutgers Univ., Rutgers-Robert Wood Johnson Med. Sch. and Drexel Univ.

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420. AGING: NUTRITION AND 10:45 421.2 Navy Bean Supplementation in Obesity GASTROINTESTINAL HEALTH Increases Akkermansia muciniphila Abundance and Attenuates Obesity-Related Impairments in Gut Barrier Function. J.M. Minisymposium Monk, D. Lepp, W. Wu, D. Graf, A.L. Hutchinson, L.E. Robinson, K.A. Power. Univ. of Guelph and Agr. and Agri- (Sponsored by: Aging and Chronic Disease RIS) Food Canada, Guelph. Tue. 10:30 am—San Diego Convention Center, Room 30A 11:00 421.3 White Tepary Bean Shows Higher In Vitro Iron Bioavailability than Brown Tepary or Common Bean. A.E. Chaired: B.H. Arjmandi Bries, M.B. Reddy, D.M. Winham. Iowa State Univ. 11:15 421.4 Studies of Cream Seeded Carioca Beans Cochaired: M.G. Miller (Phaseolus vulgaris L.) from a Rwandan Efficacy Trial: In 10:30 420.1 Food Items That Trigger a Symptom in Vitro and In Vivo (Including Effects on Intestinal Microbiome) Functional Gastrointestinal Disorders. D. Dikmen, Z. Göktaş, Screening Tools Reflect Human Studies and Predict Beneficial A. Demir, Ö. Öztürk, E. Kahramanoğlu Aksoy, H. Köklü, Y. Results from Iron Biofortified Beans. E. Tako, R.P. Glahn. Tuna, M. Kekilli, H. Korkmaz, B. Yılmaz, M. Asıl, G. Köklü, S. USDA, Cornell Univ. Köklü. Hacettepe Univ., Hacettepe Univ. Fac. of Med., Akdeniz 11:30 421.5 Effect of Dietary Pulses in a Low Glycemic Index Univ. Fac. of Med., Ankara Educ. and Res. Hosp., Selçuk Univ. Diet on Renal Function in Participants with Type 2 Diabetes Fac. of Med. and Necmettin Erbakan Univ. Meram Fac. of Mellitus. S. Blanco Mejia, C. Ireland, L.S.A. Augustin, E. Med., Turkey. Vidgen, C.W.C. Kendall, S. Mitchell, S. Sahye-Pudaruth, 10:45 420.2 Black Berry Polyphenol Reduce Nox1 Function L. Chiavaroli, A. Mirrahimi, B. Bashyam, J. Coveney, R.J. to Inhibit Senescence in Vascular Smooth Muscle Cells. J. de Souza, J.L. Sievenpiper, L.A. Leiter, R.G. Josse, T.M.S. Huang, R. Feresin, Y. Zhao, S. Pourafshar, B.H. Arjmandi, G. Wolever, V.V.V. Vuksan, P.B. Pencharz, D.J.A. Jenkins. St. Salazar. Florida State Univ. and Univ. of Arkansas for Med. Sci. Michael’s Hosp., Univ. of Toronto, Univ. of Saskatchewan, T 11:00 420.3 Capsaicin Inhibits Methionine Cotransport in Queen’s Univ., Canada, McMaster Univ., Canada and Sick U Rat Intestinal Epithelial Cells. J. Talukder, C. Cameron Hill, Kids Hosp., Toronto. E A. Jaima, J. Santiz-Lopez. LeMoyne-Owen Col., TN and 11:45 421.6 Determination of the In Vivo and In Vitro Boston Univ. Protein Quality of Pulse Protein Concentrates and Isolates. 11:15 420.4 Effect of Dietary Carboxymethyllysine on M.G. Nosworthy, J. Neufeld, J.D. House. Univ. of Manitoba. Glucose and Insulin Sensitivity, Cecal Fatty Acids and the 12:00 421.7 The Effect of a Low-Glycemic Index Pulse- Plasma Metabolome in Mice Fed the Total Western Diet. R.E. Based Diet on Performance and Body Composition in Soccer Ward, S. Xiao, M-C. Michalski, A. Geloen, K. Hintze. Utah Players. E. Mizelman, P. Chilibeck, A. Hanifi, M. Kaviani, E. State Univ. and INSA-Lyon, France. Brenna, G. Zello. Col. of Kinesiol and Col. of Pharm. and Nutr., 11:30 420.5 A High Flavonoid Diet Reduces Gut Univ. of Saskatchewan. Permeability, Short Chain Fatty Acid Production and Decreases 12:15 421.8 Toward Closing the Dietary Fiber Gap: Gut Inflammation in Overweight and Obese Men and Women. Candidate Genes Associated with Dietary Fiber Content R.E. Ward, J. Bergerson, N. Hergert, J. Hergert, S. Aguilar, in Common Bean. M.A. Brick, H.J. Thompson. Colorado A. Khan, S. Kung, M. Lefevre. Utah State Univ. State Univ. 11:45 420.6 Serum 25-Hydroxy D3 Levels in Nonalcoholic Fatty Liver Disease. Z. Goktas, S. Galyean, D. Syn, S. Koklu, 422. COMMUNITY AND PUBLIC HEALTH NUTRITION: S. Wang, M. Boylan, D. Dikmen, B. Uyar. Hacettepe Univ., COMMUNITY AND PUBLIC HEALTH Turkey, Texas Tech Univ. and Gazi Univ., Turkey. NUTRITION INTERVENTIONS 12:00 420.7 Mango (Mangifera indica L.) in the Promotion of Intestinal Regularity and Decreases Inflammation in Human Minisymposium Subjects with Constipation. S.U. Mertens-Talcott, H. Kim, S.T. Talcott, V.P. Venancio. Texas A&M Univ. (Sponsored by: Community and Public Health 12:15 420.8 Lactose Intolerance, Calcium, Vitamin D and Nutrition RIS) Parathyroid Hormone Levels in Type 2 Diabetic Patients. Tue. 10:30 am—San Diego Convention Center, Room 30C S. Rana, A. Malik, S.K. Bhadada, N. Sachdeva, R.K. Morya, G. Sharma. Post Grad. Inst. of Med. Educ. and Res., Chaired: G. George Chandigarh, India. Cochaired: J. Martin-Biggers

421. PULSES, NUTRITION AND HEALTH 10:30 422.1 B’More Healthy Communities for Kids, a Multilevel Obesity Prevention Program for African American Minisymposium Children: Wave 1 Process and Impact Results. J. Gittelsohn, A. Trude, C. Shipley, M.J. Mejia Ruiz, T. Schwendler, T. Tue. 10:30 am—San Diego Convention Center, Room 30B Eckmann, I. Loh, N. Rapp. Johns Hopkins Bloomberg Sch. of Chaired: C. Marinangeli Publ. Hlth. 10:45 422.2 HomeStyles: Recruitment Strategies for a 10:30 421.1 Effect of Dietary Pulse Consumption on Blood Childhood Obesity Prevention Randomized Controlled Trial. Pressure. S.E. Stewart, C.A. Ireland, C. de Souza, R.J. de J.T. Martin-Biggers, C. Delaney, M. Koenings, C. Byrd- Souza, S. Mitchell, L.S. Augustin, R.G. Josse, L.A. Leiter, Bredbenner. Rutgers Univ. C.W.C. Kendall, J.L. Sievenpiper, D.J.A. Jenkins. Fac. of Med., Univ. of Toronto, St. Michael’s Hosp., Toronto, McMaster Univ. and Univ. of Saskatchewan Col. of Pharm. and Nutr.

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11:00 422.3 Impact of Folic-Acid Intervention and 11:15 423.3 Measurement of Epigallocatechin Gallate MTHFRC677T Gene Polymorphism on All-Cause Mortality (EGCG) and Caffeine Content of 32 Green Tea Dietary Associated with Elevated Serum Homocysteine Levels in Supplements for the Dietary Supplement Ingredient Database. Chinese Adults with Hypertension. B. Xu, X. Kong, R. Xu, K.W. Andrews, P.T. Dang, S. Savarala, P.A. Gusev, F. Han, M. Zhao, Y. Song, C. Zhang, T. Yu, L. Liu, F. Fan, Y. Zhang, P.R. Pehrsson, J.M. Harnly, P. Chen, Y. Zhao, J.T. Dwyer, X. Qin, G. Tang, B. Wang, F.F. Hou, Y. Huo, J. Li. River Hill J.M. Betz, L.G. Saldanha, R.B. Costello. USDA, Beltsville and High Sch., Clarksville, MD, Peking Univ. First Hosp., Beijing, ODS, NIH. Nanfang Hosp., Southern Med. Univ., Guangzhou and Anhui 11:30 423.4 Are Chromium Supplements Efficacious Med. Univ., China. for Glycemic Control in Type 2 Diabetes? J.T. Dwyer, R.B. 11:15 422.4 Longitudinal Quality of Life Improvement after Costello, R.L. Bailey, E. Wambogo. ODS, NIH. a Family-Based Lifestyle Intervention in Youth with Obesity. 11:45 423.5 Do Cinnamon Supplements Have a Role S.R. Engebretsen, K. Briggs Early, R. Sorrells, J.P. Yi- in Glycemic Control in Type 2 Diabetes? R.B. Costello, J.T. Frazier, M. Sanchez, K. Gottlieb, B.L. Gonzalez, B. Lopez. Dwyer, L.G. Saldanha, R.L. Bailey, E. Wambogo. ODS, NIH Pacific Northwest Univ. of Hlth. Sci., Seattle Children’s Res. and Purdue Univ. Inst. and Yakima Valley Mem. Hosp., WA. 12:00 423.6 Menaquinone-7 Supplementation Improves 11:30 422.5 Food Label Use Improves Dietary Quality and Lipid Profile in Obese African-American Children: A Randomized Mediates Improved Glycemic Control in Latinos with Type Controlled Trial. N.K. Pollock, J. Nguyen, M.E. Fain, B.A. 2 Diabetes: The DIALBEST Trial. G. Kollannoor Samuel, Gower, R. Bassali, C.L. Davis. Georgia Regents Univ., Med. F.M. Shebl, S. Segura-Pérez, J. Chhabra, S. Vega-López, Col. of Georgia and Univ. of Alabama at Birmingham. R. Pérez-Escamilla. Yale Sch. of Publ. Hlth., Hispanic Hlth. Council, Harford, CT, Hartford Hosp. and Arizona State Univ. 424. W.O. ATWATER MEMORIAL LECTURE 11:45 422.6 Understanding Acceptance, Compliance, and Utilization of Micronutrient Powder in Northern Nigeria – Award Lecture Informing Implementation through Formative Research. S.R. Kodish, C.L. Ejembi, T. Osunkentan, A. Imohe, P. Mathema. Tue. 12:45 pm—San Diego Convention Center, Johns Hopkins Bloomberg Sch. of Publ. Hlth., Ahmadu Bello Ballroom 20D Univ., Nigeria and UNICEF Nigeria. 12:45 Introduction. 12:00 422.7 Cross-Country Comparison of the Acceptability 1:00 How Can Nutrition Scientists Help Reverse the Obesity of a Social Support Behavior Change Strategy to Improve Epidemic? S.B. Roberts. Tufts Univ. Sch. of Med. Adherence to Antenatal Calcium and Iron-Folic Acid Supplementation. S. Martin, M. Omotayo, G. Chapleau, R. 425. AFRICAN GRADUATE NUTRITION Stoltzfus, Z. Birhanu, S. Ortolano, K. Dickin. Cornell Univ. and Jimma Univ., Ethiopia. STUDENTS NETWORK 12:15 422.8 The Impact of Nutrition Label Usage on Food Selection and Consumption in a University Dining Setting. M.J. International Forum Christoph, B.D. Ellison. Univ. of Illinois at Urbana-Champaign. (Organized and Sponsored by: the African Graduate Nutrition Students Network) 423. NUTRITIONAL EPIDEMIOLOGY: RESEARCH Tue. 1:30 pm—San Diego Convention Center, Room 28DE WITH DIETARY SUPPLEMENTS AND BIOACTIVE COMPOUNDS Chaired: J. Ashong The overall goal of this session is to raise awareness of the Minisymposium African Graduate Nutrition Students Network (AGSNet) – the (Sponsored by: Nutritional Epidemiology RIS) history of the network, its goals and aspirations. The emphasis will be on the unique approach and the strategic position of the Tue. 10:30 am—San Diego Convention Center, Room 30D network to contribute to tackling the malnutrition menace on the Chaired: N. Ahluwalia African continent. The session will also highlight the importance of the strategic partnership between ASN and the AGSNet and its Cochaired: P.M. Coates implications for the future of the network. 10:30 Introduction. 1:30 Background to AGSNet formation: The Road Up to Now. 10:45 423.1 Comparison of Polyphenol Intakes in Relation N. Mbuya. World Bank. to Dietary Patterns and Food Sources in the Adventist Health 1:45 Partnerships: ASN and AGSNet. P. Stover. Cornell Univ. Study-2 Cohort. N. Burkholder-Cooley, S. Rajaram, E. 2:00 AGSNet in the Future. B. Zarhari Abu. Texas Tech Univ. Haddad, G. Fraser, K. Jaceldo-Siegl. Loma Linda Univ. 2:15 Discussion. 11:00 423.2 Daily Patterns and Factors Including Gender, Race and Occupation Associated with Caffeine Intake among US Adults: NHANES 2007-2012. H.R. Lieberman, S. Agarwal, V.L. Fulgoni III. U.S. Army Res. Inst. of Envrn. Med., Natick, MA, NutriSci. LLC, East Norriton, PA, Oak Ridge Inst. for Sci. & Educ., Belcamp, MD, Nutr. Impact LLC, Battle Creek, MI and Henry M. Jackson Fndn., Bethesda, MD.

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426. ARCHITECTURE OF HEALTHY MUSCLES: 428. DBC: DIETARY BIOACTIVE COMPONENTS AND THE INTERPLAY BETWEEN EXERCISE AND OBESITY AND METABOLIC SYNDROME NUTRITION ON MUSCLE METABOLISM Minisymposium Symposium (Sponsored by: Dietary Bioactive Components RIS) Tue. 3:00 pm—San Diego Convention Center, Room 31ABC Tue. 3:00 pm—San Diego Convention Center, Room 29A Chaired: B.B. Rasmussen Chaired: J.D. Lambert Cochaired: T.A. Davis Cochaired: K-H. Kim Clinical and Translational Nutrition 3:00 428.1 Inclusion of 100% Concord Grape Juice 3:00 Aged Muscle Protein Metabolism Responses to Physical Reduces Glucose Release following In Vitro Digestion of Inactivity and Rehabilitation. M. Drummond. Univ. a Model Carbohydrate Rich Meal. S.E. Moser, J. Lim, J.D. of Utah. Whiteman, B. Hamaker, M. Ferruzzi. Purdue Univ. 3:30 Identification of Nutritional Ingredients that Reduce Age- 3:15 428.2 Insulin and Cinnamon Polyphenol Extract related Muscle Weakness and Atrophy. C. Adams. Regulated Diacylglycerol Acyltransferase and Tristetraprolin Univ. of Iowa Carver Col. of Med. Gene Expression in Cultured Mouse Adipocytes and 4:00 Preserving Healthy Muscle During Weight Loss. Macrophages. H. Cao, R.A. Anderson. USDA, New Orleans B. Mittendorfer. Washington Univ. in St. Louis. and Beltsville, MD. 4:30 Muscle Health During Prolonged Resistance Training 3:30 428.3 Mice Fed High-Fat Obesigenic Diets with Walnut Plus Other Whole Foods Demonstrate Metabolic Improvement and Protein Supplementation. B. Rasmussen. Univ. T of Texas Med. Br. and Changes in Gene Expression and Metabolomic Patterns. N.F. Shay, T. Luo, O. Miranda, A. Adamson. Oregon State Univ. U 427. INNOVATIVE TECHNIQUES TO EVALUATING 3:45 428.4 Effect of Decaffeinated Green and Black Tea E BEHAVIORAL NUTRITION INTERVENTIONS IN Extracts on Energy Metabolism in Mice Fed a High Fat/High Sucrose/Western Diet. S.M. Henning, J. Yang, E.M. Grojean, THE COMMUNITY R-P. Lee, M. Hsu, D. Heber, Z. Li. UCLA. 4:00 428.5 Cocoa Increases Postprandial GLP-1 Symposium Response in Adults with Impaired Glucose Tolerance. K. Strat, Tue. 3:00 pm—San Diego Convention Center, Room 32AB B.M. Davy, M.W. Hulver, K.P. Davy, A.P. Neilson. Virginia Tech. 4:15 428.6 The Hypoglycaemic Potential of Antioxidant- Chaired: A.R. Mobley Rich Food Extracts. L. Chepulis. Waiariki Inst. of Technol.,

Cochaired: R.E. Scherr New Zealand. 4:30 428.7 Ingested Capsaicinoids Can Prevent Low-Fat/ Global and Community Nutrition High-Carbohydrate Diet and High-Fat Diet-Induced Obesity by Regulating the Expression of Genes for Metabolism. K. Sahin, 3:00 Current Limitations and Future Opportunities in C. Orhan, M. Tuzcu, N. Sahin, O. Ozdemir, V. Juturu. Firat Univ., Evaluating Behavioral Nutrition Interventions in Turkey and OmniActive Hlth. Technols. Inc., Morristown, NJ. the Community. A. Mobley, R. Scherr. Univ. of 4:45 428.8 Effects of Selenium in Comparison to Exendin-4 Connecticut, Univ. of California, Davis. on the Expression of GLP-1R, IRS-1 and Preproinsulin in the 3:15 An Inside Out View of Responsiveness to Nutrition Pancreas of Diabetic Rats. S. Rizk, G. Barakat, M. Moustafa, Education: What Can Functional MRI Tell Us About I. Khalifeh, M.H. Hodroj, A. Bikhazi. Lebanese American Univ. the Brain? K. Laugero. USDA ARS Western Human and American Univ. of Beirut. Nutr. Res. Ctr. 3:40 I’ll Believe It When I See It: Results of Eye-Tracking Nutrition Research. D. Graham. Colorado State Univ. 429. NUTRITIONAL EPIDEMIOLOGY: ADVANCING 4:05 Smartphone Biosensors: New Tools for Nutrition and NUTRITIONAL EPIDEMIOLOGY WITH PUBLIC Health Diagnostics. B. Cunningham. Univ. of Illinois USE AND COMMERCIAL DATA SETS at Urbana-Champaign. 4:30 The Special Case of Fruit and Vegetables: Assessing Minisymposium Community Intervention Effectiveness Using Skin (Sponsored by: Nutritional Epidemiology RIS) Carotenoid Status. L. Jahns. USDA ARS Grand Forks Human Nutrition Res. Ctr. Tue. 3:00 pm—San Diego Convention Center, Room 29B

Chaired: J. Mattei

Cochaired: K. Kordas

3:00 429.1 Total and Added Sugar Intakes among 4-13 Year Old Children in China, Mexico, and the U.S. M.C. Afeiche, B.N. Shaheen Koyratty, D. Wang, E. Jacquier, A.L. Eldridge, K-A. Lê. Nestlé Res. Ctr., Lausanne.

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3:15 429.2 Nudging Food Purchases towards Health: 4:00 430.5 Genes Associated with Amino Acid Sensing in Trends in Price Promotions and Nutrient Claims on Packaged Human Skeletal Muscle Are Altered by Amino Acid Availability Foods and Beverages. L.S. Taillie, S.W. Ng, Y. Xue, M. and Acute Lysosomal Perturbation. T.G. Graber, M.S. Borack, Harding. Univ. of North Carolina at Chapel Hill and Duke Univ. P.T. Reidy, E. Volpi, B.B. Rasmussen. Univ. of Texas Sanford Sch. of Publ. Policy. Med. Branch. 3:30 429.3 Calibrating Self-Reported MVPA Strengthens 4:15 430.6 Citrulline Is a More Efficient Supplement Than Relationship with Metabolic Syndrome. C. Ford, S. Chang, S. Arginine to Increase Systemic Arginine Availability in Mice. U. Grabich, L. Strong, M. Mendez. Univ. of Texas MD Anderson Agarwal, I.C. Didelija, J.C. Marini. Baylor Col. of Med. Cancer Ctr., EPA, Chapel Hill and Univ. of North Carolina at 4:30 430.7 Leucine in the Presence of Inflammation Alters Chapel Hill. BCAA Metabolism in Human Myotubes. E.S. Riddle, H. Roman, 3:45 429.4 Dietary Intake Assessment of Snacking among M. Ahsan, H. Shin, A. Thalacker-Mercer. Cornell Univ. Children in China and U.S. D. Wang, A.L. Eldridge. Nestlé 4:45 430.8 Genetic Background and Sex Determine Res. Ctr., Lausanne. Citrulline and De Novo Arginine Production in Mice. J.C. Marini, 4:00 429.5 Dietary Flavonoid Intake Is Negatively U. Agarwal, I.C. Didelija. Baylor Col. of Med. Associated with Anthropometric Risk Factors for Chronic Disease in Some Population Subgroups but Not Others: 431. NUTRIENT-GENE INTERACTION: CHRONIC Results from What We Eat in America, NHANES 2007-2010. DISEASE, OBESITY AND INFLAMMATION R.S. Sebastian, C. Wilkinson Enns, J.D. Goldman, L.C. Steinfeldt, A.J. Moshfegh. USDA, Beltsville, MD. Minisymposium 4:15 429.6 Has the Sodium Content of U.S. Households’ Packaged Food and Beverage Purchases Improved in the Nutrient-Gene Interaction RIS Past 15 Years? J.M. Poti, E. Dunford, B.M. Popkin. Univ. of Tue. 3:00 pm—San Diego Convention Center, Room 29D North Carolina at Chapel Hill. 4:30 429.7 Assessing the Public’s Comprehension of Chaired: J.I. Baum Dietary Guidelines: Perception of Diet Quality Is Inversely Associated with Dietary ED in U.S. Adults. J.A. Vernarelli, R. 3:00 431.1 Differential DNA Methylation between Obese + + Nouri. Fairfield Univ. and Normal Weight Women in CD4 and CD8 T Cells, and + 4:45 429.8 Socioeconomic Disparities in Dietary Intake CD16 Neutrophils. N.M. Hohos, A.K. Smith, V. Kilaru, H.J. and Food Purchasing of Foods and Beverages of Varying Park, D.B. Hausman, L.B. Bailey, R.D. Lewis, R.B. Meagher. Healthfulness in Mexico. N. Lopez-Olmedo, L.P. Smith Taillie, Univ. of Georgia and Emory Univ. B.M. Popkin. Univ. of North Carolina at Chapel Hill. 3:15 431.2 Lipoprotein Lipase Modulates Bone Marrow Myeloid Cell Proliferation by Affecting Colony-Stimulating Factor Levels and Recruitment. C.L. Chang, I.J. Goldberg, 430. ENERGY AND MACRONUTRIENT METABOLISM: R.J. Deckelbaum. Columbia Univ. and NYU. PROTEIN AND AMINO ACID METABOLISM 3:30 431.3 Genetic Ablation of TNF-α Attenuates High Fat Diet-Induced Obesity Potentially via Diminishing Wnt-Signaling Minisymposium and Determinant Genes of Adipogenesis. J. Li, A-L. Frederick, Tue. 3:00 pm—San Diego Convention Center, Room 29C Y-C. Kim, R.J. Wood, Z. Liu. Sch. of Publ. Hlth. and Hlth. Sci., Univ. of Massachusetts Amherst and USDA at Tufts Univ. Chaired: E-K. Samer 3:45 431.4 Detection of Intimal Macrophages in Atherosclerotic Lesions Using Biocompatible CD36-Targeted 3:00 430.1 Energy Deficiency, but Not Aerobic Exercise, Ligand Containing Nanoparticle. C.S. Dhanasekara, J. Zhang, Is Associated with Increased Stable Nitrogen Isotope Ratio S. Nie, S. Wang. Texas Tech Univ. of Urinary Urea. K. Koehler, U. Flenker, W. Schaenzer, F. 4:00 431.5 Congenic Mice Confirmed QTL Linked Huelsemann. Univ. of Nebraska-Lincoln and German Sport to Obesity and Hyperlipidemia on Chromosome 1 in the Univ., Cologne. TALLYHO Mouse. J.K. Parkman, X. Mao, K. Dillon, J.H. Kim. 3:15 430.2 Intermittent Leucine Pulses during Continuous Marshall Univ. Feeding Alters Novel Components Involved in Skeletal Muscle 4:15 431.6 Oral Corticosterone Administration Reduces Growth of Neonatal Pigs. A. Suryawan, C. Boutry, R. Manjarín, Insulitis but Promotes Insulin Resistance and Hyperglycemia A. Cánovas, A. Islas-Trejo, J.F. Medrano, H. Nguyen, M.L. in Male Non-obese Diabetic Mice. S.J. Burke, A.E. Eder, K.M. Fiorotto, T.A. Davis. USDA and Baylor Col. of Med., Cal Poly Regal, M.D. Karlstad, D.H. Burk, R.C. Noland, J. Collier. State Univ., San Luis Obispo, Univ. of California, Davis and Pennington Biomed. Res. Ctr., Baton Rouge and Univ. of Univ. of Guelph, Canada. Tennessee, Knoxville. 3:30 430.3 Effects of Inflammation on Arginine Transport 4:30 431.7 Exacerbation of NAFLD in Both HFD-Fed Mice and Metabolism in Human Primary Myotubes. D. Gupta, and MCD-Fed Mice by Adenosine 2A Receptor Deficiency. Y. E.S. Riddle, J.E. Blum, H. Roman, A. Thalacker-Mercer. Cai, J. Zheng, X. Guo, H. Li, Y. Pei, R. Botchlett, S-L. Woo, M. Cornell Univ. Liu, G. Chen, Y. Huo, C. Wu. Tongji Col. of Med., China, Texas 3:45 430.4 Depletion of Programmed Cell Death Protein 4 A&M Univ. and Georgia Regents Univ. (PDCD4), an mTORC1/S6K1 Substrate, Attenuates Proteolysis 4:45 431.8 Lipids and Cholesterol-Lowering Activity of in L6 Myotubes. O.J. Adegoke, S. Abou Sawan, H. Cho. York Red Cabbage Microgreens. X. Jiang, H. Huang, Z. Xiao, L. Yu, Univ., Canada. Q. Pham, L. Yu, Y. Luo, T.T.Y. Wang. Univ. of Maryland College Park and USDA, Beltsville, MD.

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432. GLOBAL NUTRITION: LINEAR GROWTH, 433. COMMUNITY AND PUBLIC HEALTH NUTRITION: GROWTH FAILURE, AND ANTHROPOMETRY COMMUNITY AND PUBLIC HEALTH APPROACHES TO OBESITY PREVENTION Minisymposium Minisymposium (Sponsored by: Global Nutrition Council) (Sponsored by: Community and Public Health Tue. 3:00 pm—San Diego Convention Center, Room 30B Nutrition RIS) Chaired: A.D. Stein Tue. 3:00 pm—San Diego Convention Center, Room 30C Cochaired: N. Perumal Chaired: S. Colby 3:00 432.1 Protein and Micronutrient Intakes Are Cochaired: M. Cardel Associated with Child Growth and Morbidity from Infancy to Adulthood in the Philippines. A. Bhargava. Univ. of Maryland 3:00 433.1 Increasing Physical Activity in American Indian Sch. of Publ. Policy. Adults: Preliminary Results from a Multi-institutional Obesity 3:15 432.2 A Plasma Proteome Is Associated with Prevention Program. L. Redmond, T. Eckmann, M. Pardilla, J. Anthropometric Status in School-Aged Children in Nepal. Swartz, H. Platero, J. Gittelsohn. Johns Hopkins Bloomberg S.E. Lee, P. Christian, K. Schulze, R.N. Cole, L.S.F. Wu, Sch. of Publ. Hlth. J.D. Yager, J. Groopman, C.P. Stewart, K.P. West; Jr. Johns 3:15 433.2 Does the Left Hand Know What the Right Hopkins Bloomberg Sch. of Publ. Hlth., Johns Hopkins Sch. of Hand Is Doing? Part Ii: Alignment between the AFRI Childhood Med. and Univ. of California, Davis. Obesity Prevention Challenge Area Program and the 2010 3:30 432.3 Length-for-Age and Weight-for-Age z Dietary Guidelines. M.M. Koenings, C. Perez, K. Krishnan, T Scores at Birth Using the World Health Organization Growth D.N. Chester. IFSN, NIFA, Washington, DC and Texas A&M Standards versus the New INTERGROWTH 21st Newborn Size Univ., Bryan. U Standards. N. Perumal, J. Shi, D. Bassani, A. Al-Mahmud, 3:30 433.3 Energy Balance-Related School Environment/ E M.M. Islam, T. Ahmad, D. Roth. Dalla Lana Sch. of Publ. Hlth., Policy Factors and Childhood Obesity in China: A National Univ. of Toronto, Hosp. for Sick Children, Toronto and icddr,b, Study of 19,487 Students from 112 Middle Schools. M. Li, H. Dhaka, Bangladesh. Xue, J. Min, M. Wen, W. Wang, Y. Wang. Univ at Buffalo, SUNY, 3:45 432.4 An Enteropathy Score Predicts Subsequent Univ of Utah and Renmin Univ of China, Beijing. Length Better Than Lactulose Mannitol Ratio Alone in 3:45 433.4 Camp NERF: Efficacy of a Theory-Based Children Enrolled in a Community-Based Randomized Trial of Nutrition Education Recreation and Fitness Program Aimed at Complementary Food Supplements in Rural Bangladesh. R. Preventing Unhealthy Weight Gain in Disadvantaged Children Campbell, K. Schulze, S. Shaikh, H. Ali, S. Mehra, L. Wu, P. during Summer Months. L.C. Hopkins, C. Gunther. The Ohio Christian. Johns Hopkins Bloomberg Sch. of Publ. Hlth. and State Univ. JiVitA, Bangladesh. 4:00 433.5 Parental Expectations and Sedentary 4:00 432.5 Maternal Docosahexaenoic Acid Behaviors among Chinese Children: A National Study of Supplementation Promotes Lean Body Mass in the Preterm 15,736 Students from 112 Middle Schools. M. Li, H. Xue, J. Infant. C.J. Valentine, J. Kleiman, K. Dingess, A. Morrow, L.K. Min, Y. Wang. Univ at Buffalo, SUNY. Rogers. Mead Johnson Nutr., Univ. of Cincinnati, Cincinnati 4:15 433.6 Consistent Weight Gain Tracking Is Associated Children’s Hosp. and The Ohio State Univ. with a Reduction in Gestational Weight Gain in High Income 4:15 432.6 Perinatal Exposure to Is Associated Women. C.M. Olson, M.L. Graham, M.S. Strawderman. with a Lower Rate of Weight Gain among HIV-Infected Cornell Univ. Pregnant Women and Reduced Linear Growth of HIV-Exposed 4:30 433.7 Sustaining the Youth-Leader Program in Infants. B.K. Natamba, J-S. Wang, S.L. Young, S. Ghosh, J.K. Baltimore City Recreation Centers: Formative Research Griffiths. Harvard Univ., Gulu Univ., Uganda, Univ. of Georgia, Findings. A. Trude, E. Anderson Steeves, C. Shipley, M.J. Cornell Univ. and Tufts Univ. Mejía Ruiz, S. Priscila, L. Lachenmayr, J. Gittelsohn. Johns 4:30 432.7 Pre-pregnancy Energy Balance, Gestational Hopkins Univ., Univ. of Tennessee, Knoxville, Fed. Univ. of São Weight Gain, and Small-for-Gestational Age in Rural Paulo, Brazil and Univ. of Maryland Ext., Columbia, MD. Gambia: The Early Nutrition and Immune Development Trial 4:45 433.8 Overweight and Obesity, Weight Perception, (ISRCTN49285450). W. Johnson, S.A.A. Elmrayed, A.M. and Weight Management Practices among Supplemental Prentice, S.E. Moore. MRC Human Nutr. Res., Cambridge Nutrition Assistance Program Education Participants in and MRC Unit, The Gambia, London. Georgia. C. Bailey, J.S. Lee, B. Olubajo. Univ. of Georgia 4:45 432.8 Non-responsive Feeding Behaviors Are Negatively Associated with Growth and Dietary Diversity at 24 Months in Rural Bangladesh. Z.T. Chowdhury, K.M. Hurley, M. Jahan, S. Shaikh, S. Mehra, H. Ali, A.A. Shamim, P. Christian. Johns Hopkins Bloomberg Sch. of Publ. Hlth. and JiVitA Proj., Bangladesh.

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434. RESEARCH AND PARTNERSHIP Opportunities Relevant to the National Nutrition OPPORTUNITIES WITHIN THE NATIONAL Research Roadmap. D.M. Klurfeld. USDA, NUTRITION RESEARCH ROADMAP Beltsville, MD. (ANDP) FORUM 3:45 Examples of Interagency Collaborations and Public Partnerships to Advance Nutritional Sciences Research. Special Session • NIH—Vitamin D Standardization Program: Progress and New Opportunities. C.T. Sempos. ODS, NIH. (Supported by Association of Nutrition Departments and • USDA—Branded Food Products Database for Public Programs ) Health: Novel Research Resource. P.E. Starke-Reed. USDA, Beltsville, MD. Tue. 3:00 pm—San Diego Convention Center, Room 28DE 4:05 Discussion. Chaired: N. Hord 435. DANONE INTERNATIONAL PRIZE IN NUTRITION Cochaired: R. Ballard AWARD CEREMONY AND LAUREATE LECTURE 3:00 Overview of the National Nutrition Research Roadmap: Purpose, Research Questions and Identification of Award Lecture Research Gaps. R. Ballard. ODP, NIH (Sponsored by: Danone Institute International.) 3:15 NIH Research Activities Addressing Research Opportunities Relevant to the National Nutrition Tue. 5:15 pm—San Diego Convention Center, Research Roadmap. P.M. Coates. ODS, NIH Ballroom 20D 3:30 USDA Research Activities Addressing Research

Pathology

436. AUTOPHAGY: BASIC MECHANISMS 437. SOCIETY OF TOXICOLOGIC PATHOLOGY AND PATHOPHYSIOLOGY SYMPOSIUM: AQUATIC TOXICOLOGY AND LESSONS FOR PREVENTION OF DISEASE Symposium Symposium Tue. 8:30 am—San Diego Convention Center, Room 3 (Sponsored by: the ASIP Environmental and Chaired: W-X. Ding Toxicologic Scientific Interest Group and the Society of Cochaired: M.J. Czaja Toxicologic Pathology)

Inflammation/Immunity Tue. 8:30 am—San Diego Convention Center, Room 4 Immunopathology Chaired: E. Galbreath

Cell Death Cochaired: D.A. Gorelick 8:30 Cellular Nutrient Signaling and Cell Growth Regulation. Environmental and Toxicologic Pathology K-L. Guan. UCSD. 8:30 Overview of Zebrafish Pathology & Model Use Screening 9:00 Mechanisms of Selective Autophagy of Subcellular Environmental Toxicology and Pharmaceutical Safety. Organelles. S. Subramani. UCSD. J. Engelhardt. ISIS Pharmaceuticals. 9:30 Autophagy in Innate Immunity and NASH. M. Czaja. 9:30 Endocrine Disrupting Activity Associated with Hydraulic Albert Einstein Col. of Med. Fracturing for Natural Gas. S. Nagel. Univ. of Missouri. 10:00 Autophagy in Pancreatitis. A. Gukovskaya. UCLA. 10:30 Environmental Estrogens and Cardiovascular 10:30 Autophagy and Drug-Induced Liver Injury. W-X. Ding. Development: New Roles for Old Hormones. Univ. of Kansas Med. Ctr. D. Gorelick. The Univ. of Alabama at Birmingham. 11:00 Autophagy in Cardiovascular Diseases. R. Gottlieb. Cedars-Sinai Heart Inst.

Visit the Exhibits April 3–April 5 Exhibit Hours Sunday–Tuesday | 9:00 AM–4:00 PM

130 TUESDAY PATHOLOGY

438. STRUCTURE AND REGULATION OF 9:50 439.6 Overexpression of Ghrelin Is Associated INTERCELLULAR JUNCTIONS: QUEST FOR with Poor Prognosis of Renal Cell Carcinoma and Promotes NEW MOLECULES AND MECHANISMS Metastasis through GHSR-Mediated Activation of AKT-Snail Pathway. T-C. Lin, S-L. Hsu, M. Hsiao. Acad. Sinica, Taipei Symposium and Taichung Veterans Gen. Hosp., Taiwan. 10:05 439.7 Long Non-coding RNA HOTAIR Activation Tue. 8:30 am—San Diego Convention Center, Room 2 by TGF-Beta1 Induces Epithelial Mesenchymal Transition in T24 Bladder Carcinoma Cells. R. Barbosa de Oliveira Brito, Chaired: A. Ivanov C.S. Malta, Y.S.T. Matos, D.M. Souza, L.H.G. Matheus, M.A. Cochaired: A. Nusrat Dalboni, H. Dellê. Nove de Julho Univ., São Paulo. 10:20 439.8 The Role of p120-Catenin and PIK3Ca in Transporters/Channels/Barriers Migration in Head and Neck Squamous Cell Carcinoma. Epithelial and Mucosal Pathobiology M. Kidacki, H.L. Lehman, P.A. Welsh, J.I. Warrick, D.B. Stairs. Penn State, Hershey. 8:30 Regulation of Adherens Junction Protein Assemblies 10:35 439.9 Epigenetic Regulation of Epithelial Cellular by Mechanical Force. W. Weis. Stanford Univ. Sch. Fate by CTBP. J.S. Byun, K. Gardner. NCI, NIH. of Med. 10:50 439.10 FoxP3+ T-Cells and PD-L1 Highlight Immune- 9:15 Tension and the Regulation of Endothelial Junctions. Suppressive Profiles in Vulvar Squamous Cell Carcinoma. A. Malik. Univ. of Illinois at Chicago. E.R. Holthoff, T. Kelly, C.M. Quick, S.R. Post. Univ. of 10:00 New Insights into Functional Coupling of Actin to the Arkansas for Med. Sci. Tight Junction Barrier. J. Anderson. NIH. 11:05 439.11 Regulative Loop between β-Catenin and 10:45 Desmogleins as Signaling Hubs to Integrate Cell Protein Tyrosine Phosphatase Receptor Type γ in Chronic Adhesion and Cell Behaviour. J. Waschke. Myeloid Leukemia. L. Tomasello, M. Vezzalini, Z. Fiorini, N. T LMU Munich. Al-Dewik, M. Yassin, C. Sorio. Univ. of Verona and Hamad U Med. Corp., Qatar. E 439. TUMOR PROGRESSION METABOLISM AND METASTASIS 440. SCIENTIFIC SLEUTHING OF HUMAN DISEASE FOR UNDERGRADUATE STUDENTS AND HIGH Minisymposium SCHOOL TEACHERS AND STUDENTS Tue. 8:30 am—San Diego Convention Center, Room 5A Special Session Chaired: W-K. Lee (Supported by an unrestricted educational grant from the Cochaired: J. McHowat Intersociety Council for Pathology Information) Cancer Biology (Sponsored by: the ASIP Education Committee)

Tumor Microenvironment and Metastasis Tue. 9:30 am—San Diego Marriott Marquis & Marina Hotel, Marina Ballroom G Neoplasia Chaired: K. Nejak-Bowen 8:30 Introductory Remarks. 8:35 439.1 Disease-Associated Polymorphisms in Mnsod Cochaired: M.B. Furie and GPx-1 Affect Metabolism, Mitochondrial Membrane Potential and Expression of Signaling Proteins. D.N. Ekoue, Education S. Bera, E. Ansong, P. Hart, V. Macias, A. Kajdacsy-Balla, M. Pulmonary Pathobiology Bonini, A.M. Diamond. Univ. of Illinois at Chicago. 8:50 439.2 Upregulation of the Multidrug Resistance Regenerative Medicine and Stem Cells P-Glycoprotein ABCB1 by Transcription Factor Pituitary 9:30 Check In. Homeobox 2 in Human Colon and Kidney Cancers. W-K. Lee, 10:00 Welcome and Introductions. K. Nejak-Bowen. Univ. F. Thévenod. Univ. of Witten/Herdecke, Germany. of Pittsburgh. 9:05 439.3 SIRT5 in Cancer Metabolic Reprogramming. 10:20 Menacing Microbes: Emerging Infectious Diseases. D.B. Lombard, J. Park, S. Kumar. Univ. of Michigan. M. Furie. Stony Brook Univ. 9:20 439.4 The Role of Twist1 Phosphorylation in Tumor 11:20 Smoking-Related Lung Disease in 3D: Not Your Angiogenesis in Lung Cancer. T. Mammoto, A. Jiang, E. Standard Lecture. P.G. Anderson, C. Caruso, J.R. Jiang, A. Mammoto. Boston Children’s Hosp. Stone, D. Zander. Penn State Milton S. Hershey 9:35 439.5 A Novel Signaling Pathway That Governs Med. Ctr. Univ. of Alabama at Birmingham and Tumor Metastasis: Ceramide Regulates Direct Crosstalk Massachusetts Gen. Hosp. between TGF- and Sonic Hedgehog Signaling. S. Gencer, Β 12:15 Stem Cells: A Case of Dr. Jekyll and Mr. Hyde. S. Monga. B. Ogretmen. Med. Univ. of South Carolina and Uskudar Univ. Univ. of Pittsburgh. and Abdullah Gul Univ., Turkey. 1:15 Tour the Exhibits at the San Diego Convention Center.

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441. LUNCH AND LEARN: SCIENCE, STATISTICS, 444. AUTOPHAGY, CELL DEATH, AND AND GETTING IT RIGHT: INTERACTIVE TISSUE INJURY DISCUSSION OF COMMON PROBLEMS Minisymposium Special Session Tue. 2:00 pm—San Diego Convention Center, Room 4 (Sponsored by: the ASIP Education Committee) Chaired: T. Li Tue. 11:45 am—San Diego Marriott Marquis & Marina Cochaired: C.C. Yates Hotel, Miramar

Chaired: D.A. Milner, Jr. Cell and Tissue Injury Immunopathology An interactive lunch session will include an opportunity for participants to review 5 case vignettes featuring a common Cell Death problem in scientific research statistics followed by a presentation and discussion with statistical faculty. The Do’s, Dont’s, and 2:00 444.1 Development of the Metabolic Syndrome Pitfalls of these methods will be highlighted and discussed. Leads to Increased Ischemic Injury and Is Associated with Dysregulated Cardiac Fasting Response and Attenuation of Autophagy in Mice. A. Andres, J. Kooren, K. Tucker, S. Parker, 442. EMERGING STRATEGIES TO E. Crowgey, N. Ravindran, B. Ito, R. Gottlieb, J. Van Eyk, R. RESOLVE INFLAMMATION Mentzer. Cedars-Sinai Med. Ctr. and San Diego State Univ. 2:15 444.2 Regulation of Cardiac Autophagic Flux In Vivo Symposium by the Ubiquitin Ligase Muscle Ring Finger-1. T.L. Parry, M.S. Willis. Univ. of North Carolina at Chapel Hill. Tue. 2:00 pm—San Diego Convention Center, Room 3 2:30 444.3 Targeting the Enterohepatic Bile Acid Signaling

Chaired: C.N. Serhan to Modulate Hepatic Autophagic Activity in Non-alcoholic Steatohepatitis. Y. Wang, Y. Ding, J. Li, H. Chavan, D. Matye, Cochaired: K. Gronert H. Ni, P. Krishnamurthy, W-x. Ding, T. Li. Univ. of Kansas Med. Ctr. Inflammation/Immunity 2:45 444.4 Nrf2 but Not Autophagy Activation Is Immunopathology Associated with Resistance to EGFR Inhibitor-Induced Lung Tumor Cell Apoptosis. Y. Li, Y. Zhou, H-M. Ni, H. Zhong, W-X. Cell and Tissue Injury Ding. Univ. of Kansas Med. Ctr. and Chest Hosp., Shanghai 2:00 Novel Mediators and Mechanisms in Resolution of Jiaotong Univ., China. Inflammation. C. Serhan. Brigham & Women’s Hosp. 3:00 444.5 High MUC2 Biosynthesis Induce ROS 2:45 Sex Specific Regulation of Tissue PMN and Lipid Production Which Increases Goblet Cell Susceptibility to ER Mediator Circuits Controls T Cell Responses in the Stress and Apoptosis. A. Tawiah, F. Moreau, K. Chadee. Univ. Eye. K. Gronert. Univ. of California - Berkeley. of Calgary, Canada. 3:30 Mesenchymal Stem Cells May Promote the Resolution 3:15 444.6 Targeting Macrophage Necroptosis of Acute Lung Injury. M. Matthay. UCSF. for Therapeutic and Diagnostic Interventions to Treat 4:15 Resolving Vascular Injury: Translational Implications for Atherosclerosis. D. Karunakaran, M. Geoffrion, L. Wei, Cardiovascular Intervention. M. Conte. UCSF. W. Gan, L. Perisic, L. Maegdefessel, U. Hedin, S. Sad, R. Virmani, T. Ruddy, K. Rayner. Ottawa Heart Inst., Karolinska 443. LIVER PATHOBIOLOGY SYMPOSIUM: LIVER Inst., Solna, Univ. of Ottawa and CVPath, Gaithersburg, MD. 3:30 444.7 Ischemia/reperfusion-Induced Myocardial PROGENITORS IN HEALTH AND DISEASE Injury in Mice with Diabetes Mellitus: Role of Silent Information Regulator 1. A. Tao, T. Mele, R. Kao, C. Martin, T. Rui. Affil. Symposium People’s Hosp. of Jiangsu Univ., Lawson Hlth. Res. Inst., (Supported by: an unrestricted educational grant from London, ON and Schulich Sch. of Med. and Dent., Western Samsara Science, Inc.) Univ., Canada. 3:45 444.8 Hydroxylase Inhibition Reduces Transforming (Sponsored by: the ASIP Liver Pathobiology Scientific Growth Factor-β1 Induced Fibrosis Associated with Colitis. Interest Group) M. Manresa, M. Tambuwala, P. Radhakrishnan, J. Harnoss, Tue. 2:00 pm—San Diego Convention Center, Room 2 M. Cavadas, C. Keogh, A. Cheong, E. Cummins, K. Barrett, M. Schneider, C. Taylor. Univiversity Col. Dublin, Univ. of Chaired: K. Nejak-Bowen Heidelberg, Systs. Biol. Ireland, Dublin and UCSD. 4:00 444.9 ATF3 as an Important Factor of the Acute Cochaired: H. Willenbring Phase Lung Inflammatory Response in an Animal Model. Liver Pathobiology C.R. Caruso, N. Cabello, U. Sinha, N. Ekpa, S. DiAngelo, Z. Chroneos, P. Silveyra. Penn State Col. of Med. 2:00 Oval Cells. B. Petersen. Univ. of Florida. 4:15 444.10 Prognostic Significance of Tissue Oxygenation 3:10 Beta-Catenin in Transdifferentiation. K. Nejak-Bowen. Changes and Early Signaling Responses in Fasciocutaneous Univ. of Pittsburgh. Advancement Flap Healing. E. Aksamitiene, L. Bryant, M. 3:45 Lineage Tracing. H. Willenbring. UCSF. Stanczak, J.R. Eisenbrey, J.B. Hoek, E.A. Pribitkin. Thomas 4:20 Progenitors in Fibrosis and Cancer. T. Kisseleva. UCSD. Jefferson Univ.

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4:30 444.11 Insulated Pathway Reporter Transposon Allows 4:05 445.9 Genistein Alleviates Testicular Ischemia and for HTS Approach to Transcriptional Activation Dynamics in Reperfusion Injury-Induced Spermatogenic Damage and Mammalian Cells. V.V. Mossine, J.K. Waters, D.L. Chance, Oxidative Stress by Suppressing Abnormal Testicular Matrix T.P. Mawhinney. Univ. of Missouri-Columbia. Metalloproteinase System. M. Al-Maghrebi. Kuwait Univ. Fac. 4:45 444.12 Characterization of Mitochondrial and of Med. Metabolic Changes following Retinal Detachment. D. Diaz- 4:20 Discussion. Aguilar, Z. Li, A. Khadka, S. Jacobo, K. Connor, M. Saint- Geniez. Massachusetts Eye and Ear Infirm., Harvard Med. 446. CLUB HEPATOMANIA (LIVER PATHOBIOLOGY) Sch. and Angiogenesis Lab., Boston. SCIENTIFIC INTEREST GROUP SPECIAL SESSION 445. MECHANISMS IN UROGENITAL DISORDERS AND INTERVENTIONS Special Session

Minisymposium (Sponsored by: ASIP Liver Pathobiology Scientific Interest Group) Tue. 2:00 pm—San Diego Convention Center, Room 5A Tue. 5:30 pm—San Diego Convention Center, Room 22 Chaired: K. Gibson-Corley Liver Pathobiology Cochaired: P. Gaffney Cell and Tissue Injury 447. ASIP SCIENTIFIC INTEREST GROUP POSTER DISCUSSION AND NETWORKING SESSION 2:00 Introduction. T 2:05 445.1 Absence of Mast Cells in the Kidneys of Rats Subjected to Fat Embolism Despite Their Presence in the Poster Discussion U Lungs and Heart. C. Patel, A.N. Fletcher, A.M. Poisner, A. (Sponsored by: ASIP Scientific Interest Groups) E Siddiqi, D. Arif, S. Hamidpour, R. Ponnapureddy, A. Molteni. Univ. of Missouri-Kansas City and Univ. of Kansas Med. Ctr. Tue. 5:30 pm—San Diego Convention Center, 2:20 445.2 Increased Indoleamine 2,3-Dioxygenase Ballroom 20BC Expression in the Renal Fibrogenesis Induced by Unilateral P1 Global Analysis of lncRNAs in Gliomas and Ureteral Obstruction. L.H.G. Matheus, G.M.S. Simão, T.A. Glioblastomas. B. Reon, A. Sinegra, A. Dutta. Univ. Amaral, R.B. Brito, C.S. Malta, Y.S.T. Matos, D.M. Souza, H. of Virginia. (1182.1) Dellê. Nove de Julho Univ., São Paulo. P2 BAC-Based Molecular Cytogenetics: From Blood to 2:35 445.3 Molecular Subtyping and In Vivo Phenotyping BAC in Just a Week. H-U.G. Weier, J.F. Weier, H. Studies Identify Human Cell Lines Suitable for Bladder Cancer Zeng, C-M. Lu, M. Wang. Lawrence Berkeley Natl. Research. J. Warrick, L. Shuman, Z. Zheng, H. Yamashita, Lab., UCSF and Caltech. (1182.4) V.O. Amponsa, D. DeGraff. Penn State Col. of Med. P3 Genome-Wide Association Analysis Identified 2:50 445.4 AA Amyloidosis in Island Foxes (Urocyon Candidate Variants Associated with Responsiveness littoralis): Pathology, Risk Factors, and the Genetic Basis for to a Blood Pressure Reduction Intervention in Rural Disease. P. Gaffney, C. Witte, D. Clifford, M. Ghassemian, North Carolina. K.C. Lenhart, K. Robasky, W. Jones, T. Gaasterland, C. Sigurdson. UCSD, Zool. Soc. of San J. Halladay, A. Ammerman, C. Patterson, J.C. Diego, Escondido and California Dept. of Fish and Wildlife, Schisler. Univ. of North Carolina at Chapel Hill and Rancho Cordova. Quintiles, Durham, NC. (1177.15) 3:05 445.5 Pathophysiological Interactions between P4 Sepsis-Associated Proteinase 3 Induces Endothelial Chronic Kidney Disease and Cardiac Remodelling. S. Liu, A.R. Permeability. E.K. Patterson, G. Cepinskas, K. Kompa, B.H. Wang, H. Krum. South China Univ. of Technol., Inoue, D.D. Fraser. Lawson Hlth. Res. Inst., London, Guangzhou Monash Univ., Melbourne. ON and Western Univ., Canada. (165.5) 3:20 445.6 Mechanisms Underlying the Induction of a P5 Increased Expression of Cytokines in a New Traumatic Profibrotic Epithelial Phenotype during Renal Fibrosis. J. Folke Model of Abdominal Aortic Aneurysms Associated Bialik, M. Rozycki, P. Speight, Z.M. Miranda, S.G. Szeto, with Hypercholesterolemic Diet in Wistar Rats. K.M. D.A. Yuen, Q. Dan, K. Szászi, S.F. Pedersen, A. Kapus. St. Mata, C.R. Fernandes, C. Tefe-Silva, E.M. Floriano, Michael’s Hosp., Toronto, Univ. of Copenhagen and Univ. S.G. Ramos. Ribeirão Preto Med. Sch., Univ. of São of Toronto. Paulo. (1177.1) 3:35 445.7 Alternation of Nephron Morphology Associated P6 Digital Determination of Chemotherapeutic Drug- with Sustained Delivery of Danazol Using Adult Male Rodents Induced Damage Sites in Single DNA Molecules Using as a Model. H.A. Benghuzzi, M.A. Tucci. Univ. of Mississppi Nanofluidic Channels. D.G. Kaufman, P.D. Chastain, Med. Ctr. S.A. Soper. Univ. of North Carolina at Chapel Hill and 3:50 445.8 Clomiphene Citrate and Male Infertility: William Carey Univ. Col. of Osteo. Med., MS. (51.8) Investigation of Treatment on Spermatogenesis and Testicular P7 Potential Pathological Implication of Osteocalcin and Histomorphology in a Rat Model. K. Gibson-Corley, P. Kogan, Vitamin D in Acute Aortic Dissection. M.M. Corsi M. Wald. Univ. of Iowa. Romanelli, E. Vianello, A. Barassi, S. Trimarchi, E. Dozio. Univ. of Milan and IRCCS Policlin. San Donato, Italy. (694.1)

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P8 VTL C3A Cells Secrete Factors Involved in Coagulation P21 Insulated Pathway Reporter Transposon Allows for HTS Homeostasis. S.L. Riley, D.F. Mendez, P.W. Bedard, Approach to Transcriptional Activation Dynamics in L.K. Landeen. Vital Therapies Inc., San Diego. Mammalian Cells. V.V. Mossine, J.K. Waters, D.L. (924.10) Chance, T.P. Mawhinney. Univ. of Missouri-Columbia. P9 Sequence Variation in Hepatitis B Virus Variants (444.11) of Chronically Infected Saudi Patients and Their P22 Epigenetic Silencing of MicroRNA-34a in Human Interaction with Host Genetic Factors. F.N. Almajhdi, Cholangiocarcinoma Cells via DNA Methylation and A. Al-Qudari, H.M. Amer, A.A. Abdo. Col. of Sci. and EZH2: Impact on Regulation of Notch Pathway. H. Col. of Med., King Saud Univ. (925.5) Kwon, K. Song, C. Han, J. Zhang, N. Ungerleider, L. P10 Rift Valley Fever Virus Protein Detected by Multiple Yao, T. Wu. Tulane Univ. (56.3) Immunohistochemical Methods. M. Gamez, B. P23 The Histone Deacetylase Sirt2 Regulates Slug in Basal- Faburay, B.S. Drolet, W.C. Wilson, J.A. Richt, A.S. Like Breast Cancer. W. Zhou, C. Kuperwasser. Tufts Davis, E. Stietzle. Col. of Vet. Med., Kansas State Univ. Sch. of Med. and Tufts Univ. (698.5) Univ. (925.16) P24 Regulome-Seq: Searching for Single Nucleotide P11 Targeting CSE1L in Colorectal Cancer. J. Pimiento, Variants Associated with Disease beyond Protein- K.G. Neill, E. Henderson-Jackson, S. Eschrich, Coding Regions. M. Pinsach-Abuin, J. Mates, B. del D-T. Chen, K. Husain, D. Shibata, D. Coppola, M. Olmo, C. Allegue, R. Brugada, I. Garcia-Bassets, S. Malafa. Moffitt Cancer Ctr., Tampa.(515.5) Pagans. Univ. of Girona, Spain, UCSD. (1180.4) P12 EXPEL: A Novel Non-destructive Method for Mining P25 Knockdown of Mechanosensitive miRNA Cluster—miR- Soluble Tumor Biomarkers. A. Turtoi, B. Costanza, 106b~25 Decreases Endothelial Proliferation and O. Peulen, A. Bellahcène, E. De Pauw, O. Detry, P. Prevents Atherosclerosis in ApoE-/- Mice. S. Kumar, Delvenne, V. Castronovo. Univ. of Liege and Univ. H. Jo. Emory Univ. (165.1) Hosp. Liege, Belgium. (515.2) P26 Whole Transcriptome Analysis of Osteosarcoma. S. P13 Single-Cell Biomarker Detection Identifies Heterogeneity Koks, E. Reimann, K. Maasalu, G. Koks, D.H. Xuan, within Cancer Populations. D. Weldon, Y. Williams, A. E. Prans, A. Martson. Univ. of Tartu, Estonia. (515.6) Patel. EMD Millipore, CA. (515.4) P27 Long Non-coding RNA HOTAIR Activation by TGF- P14 A New Composite Biomarker for Cervical Cancer Beta1 Induces Epithelial Mesenchymal Transition Diagnosis. O. Markovic, N. Markovic. Global Acad. in T24 Bladder Carcinoma Cells. R. Barbosa de for Women’s Hlth. and BioSciCon Inc., Rockville, MD. Oliveira Brito, C.S. Malta, Y.S.T. Matos, D.M. Souza, (696.5) L.H.G. Matheus, M.A. Dalboni, H. Dellê. Nove de P15 CD44, CD133 and Lgr5 as Biomarkers for Early Julho Univ., São Paulo. (439.7) Detection of H. pylori-Associated Gastric Cancer. R. P28 The Role of CtBP in Tumor Progression: Insights from Walker, J. Mejia, H. Enderling, J.M. Pimiento, M. the Pinducer Inducible Gene Expression System. D.I. Malafa, D. Coppola. Moffitt Cancer Ctr., Tampa and Yi, D. Li, S. Park, L. Crawford, G. Liang, M. Kabbout, Pathol. Inst. Mejia Jimenez, Colombia. (696.4) R. Hernandez-Mora, T. Yan, J. Byun, K. Gardner. P16 Overexpression of Ghrelin Is Associated with Poor NCI, NIH. (698.11) Prognosis of Renal Cell Carcinoma and Promotes P29 Cellular Stress Response 1 Regulates RNA Splicing Metastasis through GHSR-Mediated Activation of of Epidermal Growth Factor Receptor and Platelet- AKT-Snail Pathway. T-C. Lin, S-L. Hsu, M. Hsiao. Derived Growth Factor Receptor through Inactivation Acad. Sinica, Taipei and Taichung Veterans Gen. of Splicing Factor 3A3. J. Luo, Z-H. Zuo, Y.P. Yu. Univ. Hosp., Taiwan. (439.6) of Pittsburgh. (920.4) P17 Influence of PI3K and MAPK Pathway Mutations on P30 Aberrant Modulation of the BRCA1 and G1/S Cell Cycle Response to Mono and Dual Treatment with Targeted Pathways in Alcoholic Hepatitis Patients with Mallory Kinase Inhibitors. R.S. McNeill, D.A. Canoutas, R.E. Denk Bodies Present Revealed by RNA Sequencing. Bash, R.S. Schmid, B.H. Constance, G.L. Johnson, H. Liu. LA BioMed/Harbor UCLA Med. Ctr. (924.12) C.R. Miller. Univ. of North Carolina at Chapel Hill. P31 Deterministic Transfection and Genetic Manipulation of (515.1) Organotypic Brain Slice Cultures for Ex Vivo Imaging. P18 Exploring the Proteomic and Genomic Relationships P.E. Gygli, S. Byers, N. Higuita-Castro, C. Czeisler, between CtBP Expression and Metabolic Imbalance D. Gallego-Perez, J.J. Otero. The Ohio State Univ. in Breast Cancer. L. Crawford, R. Hernandez-Mora, and Kenyon Col., OH. (51.9) S. Park, J.S. Byun, K. Gardner. NIMHD, NIH and P32 MicroRNA Profiling in Rat Model of Neurofibrillary NCI, NIH. (698.13) Degeneration. M. Cente, N. Kosikova, P. Filipcik, P19 Characterizing Breast Cancer Stem Cell Populations In M. Novak. Inst. of Neuroimmunol. SAS and Axon Vitro Using the Sore6 Gene Reporter System. D. Li, Neurosci. SE, Bratislava, Slovakia. (1180.5) D.I. Yi, S. Park, G. Liang, M. Kabbout, J. Byun, K. P33 Role of Gfi1 Transcription Factor in Myeloma Cells Gardner. NIMHD and NCI, NIH. (698.10) Growth and Survival. D.N. Petrusca, C. Park, F. P20 Intronic Regulation of Human GLI1 DNA by cis DNA Wang, J. Anderson, D.G. Roodman. Indiana Univ. Elements and Epigenetic Marks. P. Iannaccone, R. and Richard L. Roudebush VA Med. Ctr., Indianapolis. Taylor, J. Long, R. Childs, J. Yoon, K. Sylvestersen, (1180.6) M.L. Nielsen, D.O. Walterhouse, D. Robbins. P34 Twist1 Phosphorylation Contributes to Pulmonary Northwestern Univ., Univ. of Miami and Univ. of Fibrosis through Angiopoietin-Tie2 Signaling. A. Copenhagen. (1180.1) Mammoto, A. Jiang, E. Jiang, T. Mammoto. Boston Children’s Hosp. (160.1)

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P35 Dysregulation of miRNA Regulatory Networks by Chronic P49 Platelets Direct Leukocytes to Their Sites of Ethanol Consumption Impairs Liver Regeneration. A. Extravasation. G. Zuchtriegel, B. Uhl, D. Puhr- Parrish, E. Juskeviciute, J.B. Hoek, R. Vadigepalli. Westerheide, M. Pörnbacher, K. Lauber, F. Thomas Jefferson Univ. (56.10) Krombach, C.A. Reichel. Ludwig Maximilian Univ. of P36 Epigenetic Regulation of Epithelial Cellular Fate by Munich. (165.7) CTBP. J.S. Byun, K. Gardner. NCI, NIH. (439.9) P50 JAM-C Deficiency Primes Endothelial Cells for a P37 Apigenin Attenuates CCL2 Release from TNFα and IL- Pro-inflammatory State. N. Reglero, R. Beal, C. 1a Stimulated MDA-MB-231 Triple Negative Breast Cabrera, C. Pickworth, M. Golding, J. Whiteford, T. Cancer Cells. D.F. Bauer, E.A. Mazzio, K.F. Soliman. Nightingale, B. Imhof, M.R. Barnes, S. Nourshargh. Col. of Pharm. and Pharmaceut. Sci., Florida A&M Barts and London Sch. of Med. and Dent., Queen Univ. (698.14) Mary Univ. of London and Ctr. Med. Univ., Univ. of P38 PEDF Reduction Induced by Cigarette Smoke: A Geneva. (165.10) Potential Role for Breast Tumor Development. S.E. P51 Cell-Type Specific Mechanisms Regulate Rhythmic Kispert, J. McHowat. Saint Louis Univ. Sch. of Med. Leukocyte Migration to Tissues. W. He, K. Kraus, (698.12) D. Druzd, A. de Juan, L. Ince, C-S. Chen, C. P39 Exploring Molecular and Morphological Relationships Scheiermann. Ludwig Maximilians Univ., Munich. between Obesity and CtBP in Breast Cancer. (165.11) S.S. Park, D.I. Yi, D. Li, L. Crawford, G. Liang, M. P52 Neuropilin 2 Deficiency Prolongs Skin Inflammation and Kabbout, R. Hernandez, T. Yan, S. Ambs, J.S. Byun, Edema. D.R. Bielenberg, P. Mucka, N. Levonyak, K. Gardner. NCI and NIMHD, NIH. (515.9) E. Geretti, B.M.M. Zwaans, X. Li, I. Adini, M. P40 PAF/PAF-R Expression and Effects of Cigarette Smoke Klagsbrun, R.M. Adam. Harvard Med. Sch., Boston Exposure in Human Breast Cancer. S.E. Kispert, Children’s Hosp. (165.4) T. Schwartz, J. McHowat. Saint Louis Univ. Sch. of P53 Endotoxin-Stimulated Hepatic Stellate Cells Increase T Med. (698.4) Suppressive Potential of Regulatory T Cells via IDO- U P41 Expression and Function of Androgen Receptor in Mediated AhR Activation: Therapeutic Implications. S. E Human Breast Cancer-Associated Fibroblasts: May Kumar, A. Dangi, C.R. Gandhi. Univ. of Cincinnati Androgens Shape Breast Tumor Microenvironment? and Cincinnati Children’s Hosp. Med. Ctr. (57.7) M. Lanzino, A. Campana, C. Giordano, I. Barone, D. P54 Differential Regulation of Macrophage Glucose Bonofiglio, S. Catalano, S. Andò. Univ. of Calabria, Metabolism by M-CSF and GM-CSF: Implications for Italy. (698.9) 18F-FDG PET Imaging of Inflammation. S. Tavakoli, P42 Breast Cancer Emergence from Dormancy Can Be J.D. Short, K. Downs, N. Huynh Nga, R. Asmis. Activated by Hepatic Stellate Cells. A.S. Khazali, A. Univ. of Texas Hlth. Sci. Ctr. at San Antonio. (57.8) Clark, S. Wheeler, A. Wells. Univ. of Pittsburgh and P55 Vesicle Fusion Protein, YKT6, Is a Novel Regulator VA Pittsburgh Healthcare Syst. (698.8) of Epithelial Cell-Matrix Adhesion and Migration. A. P43 Control of Breast Cancer through the Resolution of Ivanov, N. Naydenov, S. Joshi, A. Feygin. Virginia Inflammation. D.R. Vatnick, K. Lehner, M. Gilligan, Commonwealth Univ. (305.5) D. Panigrahy, Y. Gus-Brautbar, S. Ramon, S. Huang, P56 Intestinal Epithelial Cell Expression of CD47 Facilitates C. Serhan. Beth Israel Deaconess Med. Ctr., Harvard Proliferation, Neutrophil Transmigration, and Wound Med. Sch., Brigham and Women’s Hosp. and Inst. for Healing In Vivo. M. Reed, A-C. Luissint, A. Nusrat, Systs. Biol., Seattle. (698.3) C.A. Parkos. Univ. of Michigan. (305.6) P44 TIMP-2: A Novel Biologic Therapy for Triple Negative P57 Cortactin Is Required to Maintain Intestinal Epithelial Breast Cancer. N.P. Castro, A. Chowdhury, S.M. Barrier Homeostasis. A.F. Citalán-Madrid, A. García- Jensen, F. Cuttitta, W.G. Stetler-Stevenson, D. Ponce, H. Vargas-Robles, A. Betanzos, P. Nava, K. Solomon. NCI at Frederick and NCI at Shady Grove, Rottner, R. Menningen, M. Schnoor. CINVESTAV- MD. (698.2) IPN, Mexico City, Tech Univ. Braunschweig and Univ. P45 Lactate Dehydrogenase A May Not Be Primarily Hosp. Münster, Germany. (305.8) Responsible for Maintaining High Tumor Lactic Acid P58 The Specialized Pro-resolving Lipid Mediator Resolvin Levels in Aggressive Breast Cancer. N. Mack, E. E1 Promotes Intestinal Mucosal Wound Repair. M. Mazzio, K. Soliman. Florida A&M Univ. (698.1) Quiros, H. Nishio, G. Leoni, R. Agarwal, G. Bernal, P46 Characterizing Bone Tropism of Human ER+ Breast C. Gerner-Smith, C. Gerner-Smith, R. Colas, K. Cancer Cell Lines in a Murine Bone Metastasis Graham, C. Serhan, A. Garcia, C. Parkos, A. Nusrat. Model. J.N. Cheng, J.B. Frye, S.A. Whitman, J.L. Univ. of Michigan, Inst. for Cardiovasc. Prevent., Funk. Univ. of Arizona. (698.15) Munich, Georgia Tech, Emory Univ. and Harvard P47 Breast Tumor Development and Cigarette Smoking: Univ. (305.7) Accelerated Tumor Development in Calcium P59 Keratin Filaments Regulate Binding Properties of the

Independent Phospholipase A2γ Deficient Mice. Desmosomal Adhesion Molecule Desmoglein 3. F. S.E. Kispert, J. McHowat. Saint Louis Univ. Sch. of Vielmuth, F. Loschke, T.M. Magin, J. Waschke, V. Med. (698.6) Spindler. Ludwig Maximilians Univ. Munich and Univ. P48 The Critical Role of SENP1-Mediated GATA2 of Leipzig. (305.4) DeSUMOylation in Graft Arteriosclerosis by Promoting Endothelial Activation. C. Qiu, Y. Wang, X. Zhu, L. Song, H. Zhang, L. Qin, G. Tellides, W. Min, L. Yu. Zhejiang Univ. Col. of Life Sci., China and Yale Univ. Sch. of Med. (165.3)

135 PATHOLOGY TUESDAY

P60 Role of Hypoxia-Inducible Factor on Colonic Goblet Cell P72 Alveolar Lipid Accumulation in GMCSFRβ KO Mice Differentiation and Function during Mucosal Healing. Involves Epithelial Steatosis as Well as Macrophage A.K. Whitney, K.D. Schwisow, A.J. Bayless, L. Lipotoxicity and Is Not Associated with Altered Golden-Mason, G. Mehta, K.A. Kuhn, S.P. Colgan, Surfactant Lipid Synthesis. D.J. Corkill, A.N. E.L. Campbell. Univ. of Colorado Anschutz Med. Hunt, M.J. Hinrichs, M.C. Rebellato, P. Ryan, A. Campus. (305.10) Scott, M.A. Sleeman, A.D. Postle. MedImmune P61 Sympathetic Signaling Regulates Cardiomyocyte Ltd, Cambridge, U.K., Univ. of Southampton and Cohesion via the Plaque Protein Plakoglobin. C. MedImmune, Gaithersburg, MD. (921.2) Schinner, A. Schlipp, V. Rötzer, F. Vielmuth, A. P73 Allergen-Induced Endoplasmic Reticulum Stress Messoudi, A. Horn, V. Spindler, J. Waschke. Ludwig Regulates Lung Inflammation and Fibrosis. S. Maximilians Univ. Munich. (305.9) Jalahalli Mariswamy, E.M. Nakada, B. Mihavics, P62 Central Role for Intestinal Epithelial IL-10R1 Signaling S. Hoffman, D. Chapman, C.G. Irvin, A. Dixon, M. in Barrier Restitution. J.M. Lanis, E.E. Alexeev, Poynter, V. Anathy. Univ. of Vermont. (50.3) D.J. Kao, D.A. Kitzenberg, K.D. Schwisow, D.J. P74 Mitochondrial Dysfunction in iPSC-Derived Neurons in Kominsky, S.P. Colgan. Univ. of Colorado Anschutz Subjects with Chronic Mountain Sickness. H. Zhao, G. Med. Campus and Montana State Univ. (305.2) Perkins, D. Callacondo, O. Appenzeller, G. Haddad. P63 Cell Differentiation in the Murine Intestine Requires UCSD, Lima, Peru and Univ. of New Mexico. (1179.9) NADPH Oxidase 1. T. Darby, R. Jones. Emory Univ. P75 NLRP3 Inflammasome as a Novel Target for (57.3) Docosahexaenoic Acid and Its Metabolites to Abrogate P64 High MUC2 Biosynthesis Induce ROS Production Which Glomerular Injury during Hyperhomocysteinemia. Z. Increases Goblet Cell Susceptibility to ER Stress and Chen, S.M. Conley, G. Li, M. Xia, T.W. Gehr, K.M. Apoptosis. A. Tawiah, F. Moreau, K. Chadee. Univ. of Boini, P-L. Li. Virginia Commonwealth Univ. (701.1) Calgary, Canada. (444.5) P76 Behavioral Effects of a Novel Allosteric Potentiator of the P65 Cleavage of the Osmotic Stress-Related Transcriptional Dopamine D1 Receptor in Human D1 Knock-In Mice Regulator NFAT5 Is Critical for Cardiac Injury in and Rhesus Monkeys. K.A. Svensson, J.P. Beck, Coxsackievirus B3-Induced Myocarditis. Y. Qiu, P.J. J. Hao, J.M. Schaus, D.L. Maren, M.M. Menezes, Hansen, M. Zhang, D. Yang. Univ. of British Columbia J.F. Falcone, W. Anderson, K. Knopp, B.L. Adams, and Ctr. for Heart Lung Innovation, Vancouver. J.M. Witkin, X. Li, J. Cramer, A.J. Harper, K.A. (920.10) Wafford, L. Zhang, C.R. Yang, R.F. Bruns. Eli Lilly, P66 Targeting Macrophage Necroptosis for Therapeutic and Indianapolis and Erl Wood, U.K. and Chempartner, Diagnostic Interventions to Treat Atherosclerosis. Shanghai. (708.2) D. Karunakaran, M. Geoffrion, L. Wei, W. Gan, P77 Expression of Nerve Membrane Proteins in a Naturally L. Perisic, L. Maegdefessel, U. Hedin, S. Sad, R. Occurring Ca2+ Channelopathy. N. Colón-Carrion, A. Virmani, T. Ruddy, K. Rayner. Ottawa Heart Inst., Colón-Rodriguez, W.D. Atchison. Univ. of Puerto Karolinska Inst., Solna, Univ. of Ottawa and CVPath, Rico at Cayey and Michigan State Univ. (1188.5) Gaithersburg, MD. (444.6) P78 Assessment of Autofluorescent Signatures in Multiple P67 Functional Diversity of Novel Disease Mutations in the Tissue Types with Novel Excitation-Scanning Unfolded Protein Response Regulator, ATF6. W-C. Hyperspectral Imaging. P.F. Favreau, J.A. Deal, D.A. Chiang, P. Chan, J.H. Lin. UCSD. (920.13) Weber, T.C. Rich, S.J. Leavesley. Univ. of South P68 Characterization of Mitochondrial and Metabolic Alabama. (51.1) Changes following Retinal Detachment. D. Diaz- P79 MUSE: A New, Fast, Simple Microscopy Method for Aguilar, Z. Li, A. Khadka, S. Jacobo, K. Connor, M. Slide-Free Histology and Surface Topography. R.M. Saint-Geniez. Massachusetts Eye and Ear Infirm., Levenson, F. Fereidouni. Univ. of California Davis Harvard Med. Sch. and Angiogenesis Lab., Boston. Med. Ctr., Sacramento. (51.3) (444.12) P80 Potential of Hyperspectral Imaging for Label-Free P69 ATF3 as an Important Factor of the Acute Phase Lung Tissue and Pathology Classification. J.A. Deal, P. Inflammatory Response in an Animal Model. C.R. Favreau, D. Weber, T. Rich, S. Leavesley. Univ. of Caruso, N. Cabello, U. Sinha, N. Ekpa, S. DiAngelo, South Alabama. (51.2) Z. Chroneos, P. Silveyra. Penn State Col. of P81 Lymphocyte Response Assay: Report on Precision of Med. (444.9) Novel Cell Culture Test. A.E. Lynch, R. Jaffe. Hlth. P70 Transgenic Up-Regulation of Claudin-6 Decreases Studies Collegium, Ashburn, VA. (51.4) Diesel Particulate Matter-Induced Pulmonary P82 FLIM-FRET Imaging of Ligand-Receptor Binding in Inflammation. J. Bodine, J. Gassman, D.C. Milner, Tumor Cells In Vitro and In Vivo. M.M. Barroso, A. A. Lewis, T. Dunaway, K. Egbert, C. Christiansen, Rudkouskaya, S. Patel, N. Sinsuebphon, X. Intes. A. Christiansen, T. Monson, D. Broberg, J. Arroyo, Albany Med. Col. and Rensselaer Polytech Inst. P.R. Reynolds. Brigham Young Univ. (305.11) (51.7) P71 The Roles of Matrix Metalloproteinases in Anterior P83 How Different Are We? Performing Formalin Fixed Regeneration in Aeolosoma viride. T.L. Tseng. Natl. Paraffin Embedded Tissue Immunohistochemistry Taiwan Univ. (923.2) across Species. K.N. Gibson-Corley, G. Ofori- Amanfo, M.R. Leidinger, A.M. Lambertz. Univ. of Iowa. (51.6)

136 TUESDAY PATHOLOGY

P84 R-Ras Subfamily Proteins Elicit Distinct Physiologic P96 The Biophysical Determinants of Prion Neuroinvasion. Effects and Phosphoproteome Alterations in C. Sigurdson, J. Lawrence, C. Bett, T. Kurt, C. Wu, Neurofibromin-Null MPNST Cells. A. Prechtl, N. W. Surewicz, K.P.R. Nilsson. UCSD, Case Western Brossier, S. Barnes, L. Wilson, S. Brosius, S. Byer, Reserve Univ. and Linköping Univ., Sweden. (518.2) S. Carroll. Med. Univ. of South Carolina and Univ. of P97 The Molecular Basis for Cross-Species Prion Alabama, Birmingham. (1179.8) Transmission. T. Kurt, L. Jiang, N. Alderson, J. Liu, P85 111In-DANBIRT as an In Vivo SPECT/CT Imaging Tool for D. Eisenberg, C. Sigurdson. UCSD and UCLA. the Expression of LFA-1 in the Inflammatory Process (814.7) of Atheroma Development. R.I. Mota, T. Daniels, M. P98 AA Amyloidosis in Island Foxes (Urocyon littoralis): Nysus, S. Lucas, J. Norenberg, M. Campen. Col. of Pathology, Risk Factors, and the Genetic Basis Pharm., Univ. of New Mexico. (1177.22) for Disease. P. Gaffney, C. Witte, D. Clifford, M. P86 A Novel Bioinspired Microfluidic Assay for Investigation Ghassemian, T. Gaasterland, C. Sigurdson. UCSD, of the Role of Protein Kinase C-Delta in Human Zool. Soc. of San Diego, Escondido and California Neutrophil-Endothelium Interaction during Acute Dept. of Fish and Wildlife, Rancho Cordova. (445.4) Inflammation. F. Soroush, Y. Tang, P. Pandian, L.E. P99 Caveolin-1 Regulation of DISC1 as a Potential Kilpatrick, M.F. Kiani. Temple Univ. and CFD Res. Therapeutic Target for Schizophrenia. A. Kassan, J. Corp., Huntsville, AL. (1177.3) Egawa, Z. Zhang, Y. Lajevardi, K. Kim, Q.M. Nguyen, P87 Fenofibrate Induces Cardiac Fibrosis in Mice Lacking the E.S. Posadas, A. Sawada, D.V. Jeste, D.M. Roth, Co-chaperone and E3-Ubiquitin Ligase CHIP. S. Ravi, P.M. Patel, H.H. Patel, B.P. Head. UCSD. (518.3) M.S. Willis, P. Lockyer, C. Patterson, J.C. Schisler. P100 Role of Hippocampal Neurogenesis in Drug Addiction. Univ. of North Carolina at Chapel Hill. (306.8) R.J. Morales Silva, M.H. Galinato, C. Mandyam. P88 Hydroxylase Inhibition Reduces Transforming Growth Univ. of Puerto Rico, Ponce and The Scripps Res. Factor-β1-Induced Fibrosis Associated with Colitis. Inst. (518.4) T M. Manresa, M. Tambuwala, P. Radhakrishnan, P101 Effect of Stabilizing Alpha Synuclein-Membrane U J. Harnoss, M. Cavadas, C. Keogh, A. Cheong, Interactions on the Protein’s Aggregation and E E. Cummins, K. Barrett, M. Schneider, C. Taylor. Neurotoxicity. D. Ysselstein, V. Mishra, G. McCabe, Univiversity Col. Dublin, Univ. of Heidelberg, Systs. J-C. Rochet. Purdue Univ. (518.7) Biol. Ireland, Dublin and UCSD. (444.8) P102 How the γPKC Activity Is Regulated in Neurodegenerative

P89 Prostaglandin E2 Inhibits Monocyte Chemotactic Spinocerebellar Ataxia Type 14. N. Aslam, F. Alvi. Protein 5 Production and Secretion in Mouse Cardiac BioSystOmics, Houston and COMSAT, Lahore. Fibroblasts via EP4 Receptor. T.D. Bryson, D. (1179.3) Szandzik, P. Harding. Henry Ford Hlth. Syst. and P103 Ryanodine Receptor-Dependent Modulation of Wayne State Univ. Sch. of Med. (306.9) Experimental Autoimmune Encephalomyelitis in P90 CD36-Myeloperoxidase Connection and the Activation Mice. N.C. Osipchuk, A. Soulika, L. Cruz-Orengo, of Intestinal Fibroblasts. M. Anderson-Thomas, A. P.D. Allen, A.F. Fomina. Univ. of California, Davis. Nillas, T.A. Reaves. Med. Univ. of South Carolina. (1179.6) (922.1) P104 Regeneration of Large-Gap Peripheral Nerve Injuries P91 Amphiregulin Promotes Fibroblast Activation in Using Acellular Nerve Allografts Plus Amniotic Fluid Pulmonary Fibrosis. T. Liu, F. Gonzalez De Los Derived Stem Cells. X. Ma. Wake Forest Univ. Santos, L. Ding, Z. Wu, S.H. Phan. Univ. of Michigan. (1179.7) (50.6) P105 Effect of Disrupted Insulin and IGF-1 Signaling on the P92 R-Spondin2 Is Upregulated in Idiopathic Pulmonary Pro-apoptotic and Anti-proliferative RhoGAP, Porf-2. Fibrosis and Affects Fibroblasts Behavior. A. Q.V. Luong, W. Zhang, J. Pessia, Z. Wang, Y. Zhang, Munguia, C. Becerril, C. Mendoza, Y. Balderas, R. Y. Slyvka, F. Nowak. Ohio Univ. (1179.13) Ramirez, J. Melendez, A. Pardo, M. Selman. Biol. P106 Neonatal and Juvenile Ocular Development in Sprague- Sci., Natl. Inst. of Resp. Dis., Fac. of Sci. and Natl. Dawley Rats: A Histomorphological Study. V. Vrolyk, Inst. of Genomic Med., UNAM, Mexico City. (50.7) A. Apreutese, C. Gordon, R. Forster, A. Graham, P93 TGF-Beta Induces the Expression of Scleraxis in Lung B. Palate, J. Haruna, M-O. Benoit-Biancamano. Fibroblasts from Idiopathic Pulmonary Fibrosis. Fac. of Vet. Med., Univ. of Montreal, St. Hyacinthe M. Ramirez Aragon, M.A. Blancas Oropeza, F. and CiToxLAB, Laval, Canada and Evreux, France. Hernandez Sanchez, A. Cruz Lagunas, M.P. (1179.14) Czubryt, C. Mendoza Milla. UNAM and INER, P107 Immunohistochemical Detection of Autophagy-Related Mexico City and Inst. of Cardiovasc. Sci., Winnipeg, Proteins in Canine Appendicular Osteosarcoma. Canada. (700.4) C.R. Schott, G.A. Wood. Ontario Vet. Col., Guelph. P94 Extracellular Vesicles Isolated from Human (920.11) Mesenchymal Stem Cells Promote Resolution P108 Use of Hepatic Gene Expression Analysis to Investigate of Pulmonary Fibrosis. T.P. Shentu, S. Wong, C. Iron Accumulation in Rats Treated with an RGMc Espinoza, M. Cernelc-Kohan, J. Hagood. UCSD Antagonist Monoclonal Antibody. M.J. Liguori, P. and Rady Hosp. of San Diego. (160.2) Boeser, L. Fan, L. Huang, D. Seemann, E.A.G. P95 Role of Post-translational Modifications In Prion Strain Blomme, A. Popp, B.K. Mueller. AbbVie, North Diversity. P. Aguilar-Calvo, C. Bett, H. Eraña, J. Chicago, Abbvie Deutschland GmbH & Co., Castilla, P. Nilsson, C. Sigurdson. UCSD, CIC Ludwigshafen and AbbVie Biores. Ctr., Worcester. bioGUNE, Spain and Linköping Univ., Sweden. (1180.3) (518.1)

137 PATHOLOGY/ PHARMACOLOGY TUESDAY

P109 Echinacea purpurea Down Regulates LPS-Induced P113 Kinetics and Implications of Germinal Center Formation Expression of Pro-inflammatory and Angiogenic in Induced Bronchus-Associated Lymphoid Tissue Factors in an Ex Vivo Model of Equine Placentitis. during Influenza Infection. K.N. Gibson-Corley, A.W. C. Sloboda, S. Chico, J. Gordon, S. Bailey, K.A. Boyden, L. Tygrett, T.J. Waldschmidt. Univ. of Iowa. Zwetsloot, C. Mowa. Appalachian State Univ. and (700.5) North Carolina State Univ. Vet. Sch. (921.3) P114 Identification of Protein Kinase R and Tissue Distribution P110 Synonymous Codon Changes in Measles (HMV) in Channel Catfish. J. Ball, M. Vides, Y. Kobayashi. and Canine Distemper (CDV) Viral Nucleic Acid Fort Hays State Univ., KS. (925.3) Sequences Result in Gene-Specific Changes in P115 Biologic Potency Variation among Bovine, Ovine and Levels of Viral Protein Expression. E.W. Uhl, M.L. Porcine Heparins May Be Due to Their Differential Osborn, F.J. Michel, R.J. Hogan. Univ. of Georgia. Affinity to Antithrombin. Y. Yao, O. Bouchard, S. (517.4) Abro, D. Kahn, D. Hoppensteadt, J. Fareed. Ronnsi P111 Analysis of Forces Acting on the Equine Navicular Bone Pharma Co. LTD, China and Loyola Univ. Med. Ctr. in Normal and Dorsiflexed Positions. K.C. Ruff, M.L. (1177.11) Osborn, E.W. Uhl. Univ. of Georgia. (923.4) P116 Pulmonary Dipeptidyl Peptidase-4 Expression in Lung: P112 Upregulation of Chemokine Ligands and Receptors Relevance in Experimental Models and for Middle in the Spinal Cord of Type 2 Diabetic Monkeys. East Respiratory Syndrome Clinical Disease. D.K. N. Kiguchi, H. Ding, C.M. Peters, N.D. Kock, S. Meyerholz, P.B. McCray; Jr. Univ. of Iowa Carver Kishioka, J.D. Wagner, J.M. Cline, M-C. Ko. Wake Col. of Med. (700.7) Forest Sch. of Med. and Wakayama Med. Univ., P117 A Comparison of Ovine and Porcine Heparins and Japan. (921.6) Enoxaparins: A Case for an Alternative Source of Heparin Products. O. Bouchard, S. Abro, D. Kahn, O. Iqbal, D. Hoppensteadt, Y. Yao, J. Fareed. Loyola Univ. Med. Ctr. (1177.5) Pharmacology

448. RHOA IN FOCUS: PATHWAYS S. Miyamoto. UCSD. FROM GPCRS TO DISEASE 11:30 GPCR and RhoA Signaling in Hypertension. C.P. Mack. Univ. of North Carolina Sch. of Med.. Lecture 450. CENTRAL MECHANISMS CONTRIBUTING TO (Sponsored by: The Divisions for Cardiovascular Pharmacology and Molecular Pharmacology) NOVEL ANTIDEPRESSANT EFFICACY

Tue. 8:30 am—San Diego Convention Center, Room 16A Symposium Cardiovascular Pharmacology (Sponsored by: The Division for Neuropharmacology) Molecular Pharmacology (Cosponsored by: The Divisions for Molecular Pharmacology, Translational and Clinical Pharmacology, 8:30 Introduction. and Behavioral Pharmacology ) 8:35 RhoA in Focus: Pathways from GPCRs to Disease. J.H. Brown. UCSD. Tue. 9:30 am—San Diego Convention Center, Room 16B

Chaired: D. Lodge 449. GPCR AND RHOA AS MEDIATORS OF DISEASE Neuropharmacology Symposium Neurobiology (Sponsored by: The Divisions for Cardiovascular 9:30 Introduction. Pharmacology and Molecular Pharmacology) 9:35 Antidepressant Efficacy of Ketamine in Depressed Tue. 9:30 am—San Diego Convention Center, Room 16A Patients. G. Sanacora. Yale Univ. 10:00 The vHipp-mPFC Pathway Mediates the Sustained Cochaired: R. Neubig and S. Miyamoto Antidepressant Response to Ketamine. D. Lodge. Cardiovascular Pharmacology Univ. of Texas Hlth. Sci. Ctr., San Antonio. 10:25 Development of Prophylactics Against Stress-induced Molecular Pharmacology Depressive-like Behavior. C.A. Denny. Columbia Univ. Cancer Biology 10:50 BDNF Receptor Signaling is Differentially Altered by Novel Antidepressants. F. Carreno. Univ. of Texas 9:30 GPCR and RhoA Signaling in Fibrosis. R. Neubig. Hlth. Sci. Ctr., San Antonio. Michigan State Univ. 11:15 Evaluation of Molecular Biomarkers in an Adolescent 10:00 GPCR and RhoA Signaling in Cancer. J.S. Gutkind. UCSD. Chronic Restraint Stress Model of Depression. 10:30 GPCR and RhoA Signaling in the Nervous System. M. Graham, M. Hibicke, R. Hayslett. Mercer Univ. X. Piao. Boston Children’s Hosp. Col. of Pharm. (929.3) 11:00 GPCR and RhoA Signaling in Cardioprotection.

138 TUESDAY PHARMACOLOGY

11:30 Chronic Isolation Stress Alters Antidepressant-Like 9:55 Nicotinic Receptors as Targets for Treating Parkinson’s Behaviors in Animals Lacking RGS4. J.N. Talbot, B. Disease: Relevance to Parkinson’s Disease Therapy. Poncede Leon, C.M. Benhatzel, C.L. Nielsen, D. Alp, T. Bordia. SRI Intl. R. Kirsh, J.R. Traynor. Roseman Univ. of Hlth. Sci., Touro 10:20 Nicotinic Receptors as Targets for Treating Alzheimer’s Univ. Nevada, Roseman Univ. of Hlth. Sci. Cols. of Pharm. Disease. K. Dineley. Univ. of Texas, Med. Branch. and Med., and Univ. of Michigan Med. Sch. (929.6) 10:45 Nicotine and Interoceptive Conditioning: Implications 11:45 General Discussion. for Treating Nicotine Dependence. R. Bevins. Univ. of Nebraska-Lincoln. 451. CHRONOPHARMACOLOGY IN CANCER: 11:10 Acute Tolerance to the Discriminative Stimulus Effects DOES TIME REALLY MATTER? of Nicotine in Monkeys. M.J. Moerke, L. McMahon. Univ. of Texas Hlth. Sci. Ctr. at San Antonio. (1187.2) Symposium 11:35 A Novel Structural Landscape for Ligand Binding to the α7 Nicotinic Acetylcholine Receptor. G.A. Camacho- (Sponsored by: The Division for Cancer Pharmacology) Bustamante, K. Kaczanowska, M. Harel, J. Cornejo- (Cosponsored by: The Divisions for Drug Metabolism and Bravo, P. Taylor. UCSD and Univ. Autonomous de Pharmacology Education ) Baja California, Tijuana. (1187.9) Tue. 9:30 am—San Diego Convention Center, Room 15A 453. PATIENT-SPECIFIC STEM CELLS AS Chaired: S. Gaddameedhi MODELS FOR GENE-DISEASE, DRUG, AND ENVIRONMENT INTERACTIONS Cancer Pharmacology Cancer Biology Symposium T 9:30 Introduction. (Sponsored by: The Division for Toxicology) U 9:35 Chronopharmacology: Temporal Targets of Drug Action (Cosponsored by: The Divisions for Neuropharmacology, E and Therapeutic Implications. J. Hogenesch. Univ. Translational and Clinical Pharmacology, and Drug of Pennsylvania. Discovery and Development ) 10:05 Unraveling the Potential of Chronopharmacology through Genotoxic Stress Mediated Anti-cancer Drug Effect in Tue. 9:30 am—San Diego Convention Center, Room 15B Cancer. S. Gaddameedhi. Washington State Univ. Chaired: J.R. Richardson 10:35 Tamoxifen Resistance in Breast Cancer: The Melatonin Connection. S.M. Hill. Tulane Univ. Sch. of Med. Toxicology 11:05 Cancer Chronotherapy: Clinical Perspectives and Regenerative Medicine (Stem Cells, Tissue Outcomes. F. Lévi. Warwick University, UK. Regeneration, Biomaterials) 11:35 A Multi-scale Systems Pharmacology Approach for Personalizing Irinotecan Chronotherapy. A. Ballesta, S. Neurobiology Dulong, R. Dallmann, P. Innominato, F. Lévi. Univ. of Warwick, U.K. and INSERM Unit 935, Villejuif. (712.2) 9:30 Introduction. 11:50 Panel Discussion. 9:35 Modeling Gene-Environment Interactions in Alzheimer Disease. J.R. Richardson. Northeast Ohio Med. Univ. 10:05 Alterations of Manganese Biology in Huntington’s 452. NICOTINIC AGONIST/ANTAGONIST DRUG Disease. A. Bowman. Vanderbilt Univ. DEVELOPMENT: IMPLICATIONS FOR 10:35 Stem Cells in Inorganic Carcinogenesis. E. Tokar. TREATMENT OF NEURODEGENERATIVE AND NIEHS, NIH. ADDICTIVE DISORDERS 11:05 Leveraging Novel Technologies for Human iPSC-based Screening for Parkinson’s Disease. X. Zeng. The Symposium Buck Inst. 11:35 Panel Discussion. (Sponsored by: The Division for Behavioral Pharmacology) (Cosponsored by: The Divisions for Neuropharmacology, Molecular Pharmacology, Drug Discovery and Development, and Translational and Clinical Pharmacology)

Tue. 9:30 am—San Diego Convention Center, Room 17B

Cochaired: A. Fleckenstein and M. Quik Are You Tweeting about EB 2016? Behavioral Pharmacology To Tweet use #expbio Neurobiology Be sure to follow EB on 9:30 Chronic Nicotine Protects Against Methamphetamine- Induced Behavioral and Dopaminergic Deficits. Facebook and Twitter. A. Fleckenstein. Univ. of Utah.

139 PHARMACOLOGY TUESDAY

454. CURRENT TRENDS IN ANTIBODY DRUG 3:50 MSC Exosomes Deliver Cardioprotective miR-21. K. CONJUGATES: FROM DISCOVERY TO THE CLINIC Luther, M. McGuinness, L. Haar, H. Xu, J. Chen, M. Medvedovic, W.K. Jones. Loyola Univ. Chicago Symposium Maywood and Univ. of Cincinnati. (719.1) 4:10 Human Perivascular Adipose Tissue Contains an (Sponsored by: The Divisions for Drug Discovery and Adrenergic System. N. Ayala-Lopez, C. Pereira- Development and Drug Metabolism) Hicks, R. Burnett, G.D. Fink, S.W. Watts. Michigan (Cosponsored by: The Divisions for Molecular State Univ. (719.12) Pharmacology, Cancer Pharmacology, and Translational and Clinical Pharmacology ) 456. DIVISION FOR TOXICOLOGY SYMPOSIUM: FORTUITOUS PROTEIN MODIFICATION IN Tue. 9:30 am—San Diego Convention Center, Room 17A DISEASE PATHOGENESIS AND TREATMENT Cochaired: T. Esbenshade and L.C. Wienkers Division Symposium Drug Discovery and Development (Sponsored by: The Division for Toxicology) Drug Metabolism Tue. 3:00 pm—San Diego Convention Center, Room 15B Cancer Biology Chaired: S.S. Lau 9:30 Introduction. 9:35 Advances in Drug-Linker Design to Improve the Stability, Toxicology Homogeneity, and Pharmacokinetics of Antibody- Drug Conjugates. R.P. Lyon. Seattle Genetics. 3:00 Introduction. S.S. Lau. Wayne State Univ. 10:05 Considerations for ADC Catabolism and Catabolite 3:05 Characterization of Blood Protein Adducts Formed Disposition. D. Rock. Amgen, Inc. with Cooked Meat Carcinogens and Approaches of 10:35 Analysis of Antibody-Auristatin Conjugates for Cancer Human Biomonitoring by Ion Trap Mass Spectrometry. Therapy. S. Hengel. Seattle Genetics. R. Turesky. Univ. of Minnesota. 11:05 Leveraging Clinical Learnings and Patient Tailoring to 3:35 Dopamine Adduction to α-Synuclein and Parkinson’s Enable Next Generation Conjugate Success: Hsp90 Disease. T. Monks. Univ. of Arizona. Inhibitor Drug Conjugates (HDCs). A.C. Rigby. Synta 4:05 Visual Cycle Adducts and Diseases of Retina. Pharmaceut. Inc. J. Sparrow. Columbia Univ. 11:35 Discussion. 4:35 Dicarbonyl Protein Modification, Diabetic Complications and Metformin Therapy. S.S. Lau. Wayne State Univ. 5:00 Wide-Spread Insulin Resistance in Tyrosine 455. DIVISION FOR CARDIOVASCULAR Phosphorylation in Type 2 Diabetic Patients. Z. Yi. PHARMACOLOGY TRAINEE SHOWCASE Wayne State Univ.

Division Oral Session 457. DIVISION FOR DRUG DISCOVERY (Sponsored by: The Division for AND DEVELOPMENT SYMPOSIUM: Cardiovascular Pharmacology) CHEMICAL BIOLOGY AS AN ENGINE FOR Tue. 2:30 pm—San Diego Convention Center, Room 16A DRUG DISCOVERY

Cochaired: C. McCarthy and J. Schilling Division Symposium Cardiovascular Pharmacology (Sponsored by: The Division for Drug Discovery 2:30 Inhibiting Fibronectin Improves Cardiac Function in a and Development) Mouse Model of Heart Failure. I. Valiente Alandi, Tue. 3:00 pm—San Diego Convention Center, Room 17A M. Nieman, J.D. Molkentin, B.C. Blaxall. Cincinnati Children’s Hosp. Med. Ctr. and Univ. of Cincinnati. Cochaired: J.S. Lazo and C. Beeson (939.2) Drug Discovery and Development 2:50 Kruppel-Like Factor 15: A Critical Transcriptional Regulator of Hypoxia Induced Endothelial Arginase 2. 3:00 Introduction to the Symposium. J. Lazo. Univ. of Virginia D. Pandey, D. Hori, L. Santhanam, D. Berkowitz, L. Sch. of Med. Romer. Johns Hopkins Univ. Sch. of Med. 3:05 Developing Novel Chemical Biology Strategies to 3:10 Nanogel Drug Carriers Presenting Platelet GPIb[alpha] Synthetically Disrupt Protein:Protein Interactions. Mimic and Enhance Platelet Adhesion. J.W. Myerson, E.J. Kennedy. Univ. of Georgia. I. Johnston, J. Wu, R. McClintock, Z. Ruggeri, M. 3:40 Developing Drug-like Molecules that Alter Important Poncz, V. Muzykantov. Univ. of Pennsylvania and Biological Processes. M. Arkin. Univ. of California, The Scripps Res. Inst. San Francisco. 3:30 Reversal of Stem Cell Mobilopathy and Enhanced 4:15 Targeted Protein Degradation – What it Provides and Vascular Repair by Angiotensin-(1-7) in Diabetes. How to Achieve It. C.M. Crews. Yale Univ. G. Vasam, Y. Jarajapu. North Dakota State Univ. 4:50 Precision Biosynthesis of Natural Product Drug Leads. (1270.2) B. Moore. UCSD.

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5:25 Summary and Concluding Remarks. C. Beeson. Med. 459. DIVISION FOR NEUROPHARMACOLOGY Univ. of South Carolina. POSTDOCTORAL SCIENTIST AWARD FINALISTS

458. DIVISION FOR CANCER PHARMACOLOGY: Division Oral Session CELL SIGNALING IN CANCER BIOLOGY (Sponsored by: The Division for Neuropharmacology) AND THERAPEUTICS Tue. 3:00 pm—San Diego Convention Center, Room 16B Division Oral Session Neuropharmacology (Sponsored by: The Division for Cancer Pharmacology) Neurobiology Tue. 3:00 pm—San Diego Convention Center, Room 15A 3:00 Path to Becoming a Neuropharmacologist and the Cochaired: R.K. Guy and J.C. Yalowich Search for Novel Psychotherapeutic Drug Targets. L.C. Daws. Univ. of Texas Hlth. Sci. Ctr. Cancer Pharmacology 3:45 Chronic Cocaine Exposure Alters D1 Medium Spiny Cancer Biology Neuron Activity to Promote Relapse. E.S. Calipari, R.C. Bagot, I. Purushothaman, S. Pirpinias, T.J. 3:00 Introduction/Overview. R.K. Guy. St. Jude Childrens Davidson, K. Deisseroth, E.J. Nestler. Icahn Sch. of Res. Hosp. Med. at Mount Sinai and Stanford Univ. (1186.2) 3:05 Proteinases, Proteinase-Activated Receptors and 4:00 Chronic Antagonism of p38α MAPK Normalizes Serotonin Transient Receptor Potential Ion Channels: Clearance, Serotonin Receptor Hypersensitivity and Driving Tumorigenesis in the Bladder Cancer Social Behavior Deficits in a Genetic Murine Model Microenvironment. S. Gibson, K. Mihara, M. El-Daly, of Autism Spectrum Disorder. M.J. Robson, M.A. T M. Saifedine, M.D. Hollenberg, M.E. Hyndman. Univ. Quinlan, J. Veenstra-VanderWeele, D.M. Watterson, U of Calgary, Snyder Inst. for Chronic Dis., Cumming Sch. R.D. Blakely. Vanderbilt Univ., Columbia Univ. and E of Med. and Prostate Cancer Ctr., Calgary. (714.2) Northwestern Univ., Chicago. (707.9)

3:25 Epac1 Links Prostaglandin E2 to β-Catenin Transcriptional 4:15 Cocaine-Induced Chromatin Modifications Are Activity during Epithelial-to-Mesenchymal Transition in Associated with Increased Gene Expression and A549 Cells. S. Jansen, W. De Jager, S.J. Yarwood, DNA-DNA Interactions of AUTS2. O. Engmann, B. F. Lezoualc’h, R. Gosens, M. Schmidt. Univ. of Labonte, A. Mitchell, E. Calipari, J. Rabkin, Y. Hurd, Groningen, Netherlands, Univ. of Glasgow, U.K. and G. Turecki, S. Akbarian, E.J. Nestler. Icahn Sch. of Univ. Toulouse III, France. (714.5) Med. at Mount Sinai and McGill Univ. (1186.3) 3:45 Electrophilic Nitroalkenes Inhibit Triple Negative Breast 4:30 Rapid Antidepressant-Like Effects of the “Uptake-2” Cancer Metastasis. C-S. Woodcock, S.R. Woodcock, Blocker, Decynium 22 in the Flinders Sensitive Line C. Cao, N.E. Davidson, Y. Huang, B.A. Freeman. Rat Model of Depression. R. Fraser-Spears, W.A. Univ. of Pittsburgh, Sch. of Med. and Univ. of Pittsburgh Owens, N.C. Mitchell, D. Overstreet, W. Koek, L.C. Cancer Inst. (714.7) Daws. Univ. of Texas Hlth. Sci. Ctr. at San Antonio 4:05 Break and Univ. of North Carolina at Chapel Hill. (929.7) 4:25 Treatment of Triple Negative Breast Cancer-Derived 4:45 Impact of Chronic Ethanol Self-Administration on Kappa Cells with Polyisoprenylated Cysteinyl Amide Opioid Receptor Regulation of Dopamine Signaling in Inhibitors Activates Caspase 3/7 and Disrupts F-Actin Nonhuman Primates. C.A. Siciliano, E.S. Calipari, Organization Leading to Apoptosis and Diminished Cell S.C. Fordahl, J.R. Melchior, J.T. Yorgason, Y. Mateo, Motility. O. Salako, R. Poku, A. Nkembo, F. Amissah, C.M. Helms, V.A. Jimenez, D.M. Lovinger, K.A. Grant, E. Ntantie, N. Lamango. Florida A&M Univ. Col. of S.R. Jones. Wake Forest Sch. of Med., NIAAA, NIH, Pharm. & Pharmaceut. Sci. (936.3) Rockville and Oregon Hlth. & Sci. Univ. (704.1) 4:45 A Dock-Derived PEDF Mimic Targeting Laminin Receptor 5:00 GPR171 in the Basolateral Amygdala Regulates Stress Downregulates VEGF Receptor. C.S. Umbaugh, A. and Reward-Related Behaviors. E. Bobeck, D. Pena, Diaz-Quiñones, M. Figueiredo. Purdue Univ. and I. Gomes, W. Fujita, L. Devi. Icahn Sch. of Med. at Univ. Central del Caribe Med. Sch., PR. (936.5) Mount Sinai. (1265.9) 5:05 Synergism between Bioengineered miR-34a Prodrugand 5:15 Discussion. Doxorubicin in Suppressing Osteosarcoma cell Proliferation and Xenograft Tumor Growth. M. Tu, Y. Zhao, Y. Yu, W. Wang, Q. Chen, J. Qiu, A. Yu, A. Yu. Univ. of California Davis, Sacramento, Wuhan Univ., China and Univ. of Buffalo. (936.1)

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460. PAUL M. VANHOUTTE DISTINGUISHED The Paul M. Vanhoutte Award in Vascular Pharmacology LECTURESHIP IN VASCULAR PHARMACOLOGY was established to honor Dr. Vanhoutte’s lifelong scientific contributions to our better understanding and appreciation Award Lecture of the importance of endothelial cells and vascular smooth muscle function in health and disease and for his mentoring (Sponsored by: The Division for of countless prominent endothelial and vascular biologists Cardiovascular Pharmacology) and pharmacologists. Tue. 4:30 pm—San Diego Convention Center, Room 16A 4:30 Introduction. Cardiovascular Pharmacology 4:35 Capillaries as Decoders of the Neural Rhythm of the Brain: Translating Thought into Blood Flow. M. Nelson. Univ. of Vermont. Physiology

461. APS PRESIDENT’S SYMPOSIUM SERIES 9:30 Soluble Vimentin Decreases Neutrophil Adhesion PHYSIOLOGICAL MECHANISMS to Platelets by Inhibiting P-Selectin Glycoprotein RESPONSIVE TO BEHAVIORAL AND Ligand-1-P-Selectin Interactions. F.W. Lam, Q. Da, M. ENVIRONMENTAL CHALLENGES Cruz, C.W. Smith. Baylor Col. of Med. and Michael E. DeBakey VA Med. Ctr., Houston. (1210.4) 9:45 Endothelial Cell Secreted MIF Regulates Pericyte PHYSIOLOGICAL ADAPTATION TO Contractility to Decrease Barrier Function. A. Pellowe, BEHAVIORAL, ENVIRONMENTAL, AND Y. Hou, M. Harris, R. Liu, J.S. Pober, A. Gonzalez. CHRONOLOGICAL STRESS Yale Univ. (1210.6)

Symposium 463. A BROAD HISTORY OF Tue. 10:30 am—San Diego Convention Center, TEMPERATURE REGULATION Ballroom 20A Symposium Chaired: L. Simon and A.M. Whitaker (Sponsored by: APS History of Physiology Group) Environmental Stress Tue. 8:00 am—San Diego Convention Center, Room 25C 10:30 Adaptation to High Altitude. T. Simonson. UCSD. 11:00 Human Heat Acclimation. M. Sawka. Georgia Inst. Chaired: L.R. Leon and S. Kirkton of Technol. Environmental Stress 11:30 Responses of Quiescent Stem Cells to Systemic Signals. T. Rando. Stanford Univ. Med. Ctr. 8:00 Hypothalamic Control Mechanisms of Temperature 12:00 Sympathoneural and Adrenomedullary Responses to Regulation. G. Mack. Brigham Young Univ. Mental Stress. D. Goldstein. NINDS, NIH. 8:30 Temperature Regulation in Ectotherms. L. Crawshaw. Portland State Univ. 462. 2016 GABOR KALEY LECTURE 9:00 From Beer Cans to Intelligent Agents: the Evolution of FEATURED TOPIC an Evolutionary Theory of Thermoregulation and Its influence on Global Change Biology. M. Angilletta. Featured Topic Arizona State Univ. 9:30 Physiological Mechanisms of Heat Acclimation. (Sponsored by: APS Cardiovascular Section and The S. Schneider. Univ. of New Mexico. Microcirculatory Society)

Tue. 8:00 am—San Diego Convention Center, Room 26 464. ADVANCES IN RENAL PHYSIOLOGY II

Chaired: S. Nourshargh Featured Topic 8:00 Neutrophil-Microvessel Interactions: Novel Concepts (Sponsored by: APS Renal Section) and Pathophysiological Implications. S. Nourshargh. Queen Mary, Univ. of London. Tue. 8:00 am—San Diego Convention Center, Room 27 8:50 Circadian Rhythms in Leukocyte Recruitment to Chaired: P. O’Connor and L. Evans Tissues. C. Scheiermann. Ludwig Maximilians Univ. Munich. (1210.1) Ion Transport 9:15 High Affinity Bent Integrin Binds Ligand in Cis and β2 8:00 The Role of the NADPH Oxidase Subunit p67phox in the Regulates Inflammation. Z. Fan, S. McArdle, Z. Regulation of Renal Blood Flow in Dahl S (SS) Rats. Mikulski, E. Gutierrez, M. Ginsberg, A. Groisman, L.C. Evans, A.J. Polichnowski, A.W. Cowley Jr. K. Ley. La Jolla Inst. for Allergy and Immunol. and Med. Col. of Wisconsin and Loyola Univ. and Hines UCSD. (1210.2) VA Hosp., Maywood, IL. (739.7)

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8:15 Bicarbonate Therapy Has No Effect on Renal T-Cell 466. BUILDING NEURAL CIRCUITS: WIRING Infiltration or Blood Pressure but Markedly Reduces AND EXPERIENCE Tubular Casts/Fibrosis and Is Associated with an M1 to M2 Polarization in Dahl Salt-Sensitive Rats. Symposium P. O’Connor, J-K. Chen, L. Taylor, S. Ray, B. Baban, J.C. Sullivan. Georgia Regents Univ. (966.8) (Sponsored by: APS Central Nervous System Section) 8:30 Alstrom Syndrome 1, a New Interacting Protein of Tue. 8:00 am—San Diego Convention Center, Room 28A NKCC2, Regulates Apical NKCC2 Trafficking, Urinary Concentration and Blood Pressure. A.B. Jaykumar, Chaired: S.D. Van Hooser and J. Cang P. Caceres, G. Ares, W. Beierwaltes, P. Ortiz. Henry Neurobiology Ford Hosp. and Wayne State Univ. (965.11) 8:45 RORγt-Dependent Preferential Induction of IL-17F by Neurophysiology TLR3 Activation in SHR Immune Cells. M.V. Singh, 8:00 Choosing Which Way to Go: Development of Direction M.Z. Cicha, M.W. Chapleau, F.M. Abboud. Univ. of Selectivity in Visual Cortex. S.D. Van Hooser. Iowa and VA Med. Ctr. (966.7) Brandeis Univ. 9:00 Intervention with VG1177, a MHC Class II Invariant 8:30 Binocular Matching and Critical Period Plasticity in the Peptide Chain Antagonist, Restores Afferent Arteriolar Mouse Visual Cortex. J. Cang. Northwestern Univ. Autoregulatory Behavior during Chronic 14 Day 9:00 Molecules and Mechanisms that Assemble Functionally Lipopolysaccharide Treatment. J.P. Van Beusecum, Specialized Visual Pathways. A. Huberman. Univ. of A.K. Cook, S. Zhang, R.P. Tobin, K. Newell-Rogers, California, San Diego. E.W. Inscho. Univ. of Alabama at Birmingham and 9:30 Experience-Dependent Development of Visual Circuitry Texas A&M Hlth. Sci. Ctr./Baylor Scott & White Hlth. in Xenopus. H. Cline. Scripps Res. Inst. (966.5) T

9:15 Renal Cortical Hydrogen Peroxide (H2O2) Stimulates U Renin Release from Juxtaglomerular (JG) Cells and 467. JOHN FORTE GIL SECTION DISTINGUISHED E Increases Blood Pressure: Role of JG Cell NOX4. ABSTRACT PLENARY SESSION M. Mendez. Henry Ford Hosp. (1218.7) 9:30 Formyl Peptide Receptor Blockade Ameliorates Featured Topic Intrarenal Resistance Artery Function and Decreases (Sponsored by: APS Gastrointestinal and Liver Blood Pressure in SHR. C.F. Wenceslau, C.G. Physiology Section) McCarthy, T. Szasz, S. Ogbi, R.C. Webb. Georgia Regents Univ. (966.2) Tue. 8:00 am—San Diego Convention Center, Room 22 9:45 Three-Layered Proteomic Characterization of a Novel Chaired: J. Uno and Y. Zavros ACTN4 Mutation Reveals Its Pathogenic Potential in FSGS. M.M. Rinschen, M. Bartram, T. Benzing, B.B. 8:00 Sex Differences in GABAergic Neurotransmission to Beck. Univ. Hosp. Cologne. (1220.1) Gastric-Projecting DMV Neurons. Y. Jiang, M.P. D’Angelo, L. Anselmi, R.A. Travagli. Penn State Col. 465. BEYOND GWAS: ATTACHING PHYSIOLOGY TO of Med. and Univ. of Pittsburgh. (1254.4) THE GENOME 8:15 Involvement of TFF2 and Na/H Exchanger in Gastric Wound Repair In Vitro in Gastric Organoids. K.A. Symposium Engevik, A.L. Matthis, E. Aihara, M.H. Montrose. Univ. of Cincinnati. (1250.5) (Sponsored by: Physiological Genomics Journal) 8:30 Cardiorespiratory Fitness as a Predictor of Intestinal

Tue. 8:00 am—San Diego Convention Center, Ballroom 20A Microbial Diversity and Distinct Metagenomic Functions. M. Estaki, J. Pither, P. Baumeister, J.P. Chaired: P. Munroe and T. Wiltshire Little, S. Gill, S. Ghosh, Z. Ahmadi-Vand, K.R. Marsden, D.L. Gibson. Univ. of British Columbia 8:00 Challenges of Interpreting GWAS Variants to Function. Okanagan. (1027.5) P. Munroe. Queen Mary Univ. of London. 8:45 Activation of Nlrp3 Inflammasomes in Mouse Hepatic 8:30 Utility of Model Systems for Functional Testing and Stellate Cells during Schistosoma J. Infection. Physiology. B. Joe. Univ. of Toledo Coll. of Medicine. N. Meng, M. Xia, P-L. Li, W-X. Tang. Virginia 9:00 Translational of GWAS Findings to the Clinic. Commonwealth Univ. and Tongji Med. Col., Huazhong S. Padmanabhan. Glasgow Univ. Univ. of Sci. and Technol., China. (1024.1) 9:30 Cardiovascular Pharmacogenetics. T. Wiltshire. Univ. 9:00 Blocking NF- B Activation in Intestinal Lysozyme M of North Carolina at Chapel Hill. κ Positive Cells Prevents the NEC-Induced Decrease in Ly6C Positive Cells in the Neonatal Intestine. E. Managlia, X. Yan, X. Liu, J. Mangrum, I. De Plaen. Ann & Robert H. Lurie Children’s Hosp. of Chicago and Northwestern Univ., Chicago. (1023.6) 9:15 Regulation of the Antioxidant Glutathione by Enteric Glia during Inflammation. I.A.M. Brown, B.D. Gulbransen. Michigan State Univ. (1023.7)

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9:30 Nonalcoholic Fatty Liver Disease Is Associated with 8:20 Neural and Cellular Mechanisms Mediating Opioid- Dysfunction in Hepatic Circadian Rhythm. S. Larion, Induced Respiratory Depression and Strategies to J.D. Mintz, D.J. Fulton, S. Khurana, D.W. Stepp. Reverse It. G. Montandon. Univ of Toronto. Med. Col. of Georgia. (1249.5) 8:40 Opioid Effects on Respiration- Data From Preclinical 9:45 Maternal High Fat Diet Increases an Inhibitory Animal Models in Vivo. A. Stucke. Med. Col.

Extrasynaptic Tonic GABAA Current in Dorsal Motor of Wisconsin. Nucleus of the Vagus Neurons Regulating Gastric 9:00 How Opioids Interfere With Central Respiratory Control. Functions. C.A. McMenamin, K.N. Browning. Penn A. Garcia. Univ. of Washington Sch. of Med. State Col. of Med. (1252.5) 9:20 Ampakine Therapy for Opioid-induced Respiratory Depression. J. Greer. Univ. of Alberta. 468. NEURAL CONTROL OF INFLAMMATION- MEDIATED HYPERTENSION 470. ORIGINS OF ADULT CARDIOVASCULAR AND METABOLIC DISEASE Featured Topic Featured Topic (Sponsored by: APS Neural Control and Autonomic Regulation Section) (Sponsored by: APS Water and Electrolyte Homeostasis Section) Tue. 8:00 am—San Diego Convention Center, Room 28B Tue. 8:00 am—San Diego Convention Center, Room 25A Chaired: E. Lazartigues Chaired: A. Loria and E. Gillis Neurobiology 8:00 Developmental Programming in Mouse, Monkey, Inflammation/Immunity and Man: From Stem Cells to the Microbiome. Hypertension J. Friedman. Univ. of Colorado Sch. of Med. Anschutz Medical Campus. 8:00 Microglia Participate in Neurogenic Regulation of 8:30 Leptin, Melanocortin 4 Receptor and Renal Nerves Hypertension. P. Shi. Cedars-Sinai Med. Ctr. Play a Role in High Blood Pressure Programmed by 8:30 Neuroimmune Pathway Critical in Development of Intrauterine Growth Restriction in Mouse. S. Intapad. Hypertension. K. Mathis. Univ. of North Texas Hlth. Univ. of Mississippi Med. Ctr. (1214.4) Sci. Ctr. 8:45 Early-Life Stress Induces Increased Plasma Heme and 9:00 Defect Mitochondrial Biogenesis at Rostral Ventrolateral Toll-Like Receptor 4 Activation Leading to Increased Medulla in Neurogenic Hypertension under Peripheral Superoxide Production in Aortic Endothelial Cells. Inflammation. J.Y.H. Chan, K.L.H. Wu. Kaohsiung D.H. Ho, A.L. Ring, J.S. Pollock. Univ. of Alabama Chang Gung Mem. Hosp., Taiwan. (1237.1) at Birmingham and Tripler Army Med. Ctr., Honolulu. 9:15 Knockdown of Bradykinin B1 Receptor Reduces Neuro- (1214.2) inflammation and Prevents the Development of Salt- 9:00 Influence of Activity before or during Pregnancy on Fetal Sensitive Hypertension. S. Sriramula, E. Lazartigues. and Infant Heart Outcomes. L.E. May, O.R. Reoyo, LSU Hlth. Sci. Ctr., New Orleans. (1237.4) C.M. Moyer, E.R. Newton, D. Strickland. East 9:30 Cholinergic Stimulation of Immune Cells with Nicotine Carolina Univ., Tech Univ. of Madrid and Bridgewater Induces Renal Inflammation and Premature Col., VA. (1214.10) Development of Hypertension in Young SHR. 9:15 Pulmonary and Systemic Vascular Responses in Rats S. Harwani, M. Chapleau, F. Abboud. Univ. of Iowa Exposed to Perinatal Hyperoxia. T.J. Greiner, D. and VA Med. Ctr. (1237.3) Rotella, M.L. Bates. Univ. of Iowa. (1214.11) 9:45 Microglia Modulate Ang II-Induced Neuronal Activity and 9:30 Increased Hepatic Lipogenic Gene Expression Neuroinflammation. M.M. Santisteban, J. Zubcevic, Correlates with Enhanced Central and Ectopic M. Febo, M.K. Raizada. Univ. of Florida. (1237.8) Adiposity in Female C57BL6 Mice Exposed to Maternal Separation. M. Murphy, D. Cohn, C. Wills, 469. OPIOID-INDUCED RESPIRATORY DEPRESSION: L. Gilbert, D. Powell, A. Loria. Univ. of Kentucky. SITES/MECHANISMS OF ACTION AND (1214.1) POTENTIAL SOLUTIONS 9:45 Chronic Flutamide Treatment Alters Intrarenal Renin Angiotensin System Expression in Intrauterine Symposium Growth Restricted Female Rats. J.H. Dasinger, S. Intapad, B.R. Rudsenske, B.T. Alexander. Univ. of (Sponsored by: APS Respiration Section) Mississippi Med. Ctr. (1214.5) Tue. 8:00 am—San Diego Convention Center, Room 24

Chaired: H.V. Forster and J. Miller

Neurobiology Neurophysiology 8:00 Opiod Effects on Respiratory Control in Diseased States. A. Malhotra. UCSD.

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471. REDOX MEDIATED ENDOTHELIAL 473. CHRONIC LIVER DISEASES MODULATED RESPONSES: SHOWCASING NOX2 ENZYMES BY TRANSCRIPTIONAL AND IN PATHOPHYSIOLOGY TRANSLATIONAL MECHANISMS

Symposium Featured Topic (Sponsored by: APS Cardiovascular Section) (Sponsored by: APS Gastrointestinal and Liver Physiology Section) Tue. 8:00 am—San Diego Convention Center, Room 23 Tue. 10:30 am—San Diego Convention Center, Room 28B Chaired: S. Chatterjee and V. Sampath Chaired: L. Wang and K. Machida Inflammation/Immunity Inflammation/Immunity Oxidative Stress 10:30 LncRNA in Lipoprotein Metabolism. C. Wahlestedt. 8:00 Endothelial NOX2 Signaling in Cardiovascular Disease. Univ. of Miami Miller Sch. of Med. K. Channon. Univ. of Oxford. 11:00 Function of Non-Coding RNAs in Bile Acid 8:30 NOX2 in Cerebrovascular Dysfunction in Hypertension Homeostasis. L. Wang. Univ. of Connecticut Inst. for and Alzheimer’s Disease. C. Iadecola. Weill Systs. Genomics. Cornell Inst. 11:30 The Critical Role of the G Protein-Coupled Receptor 9:00 Mechanosignal via Endothelial NOX2 Activation Triggers 30, a Novel Estrogen Receptor, in the Formation inflammation During Donor Lung Preservation. of Lithogenic Bile through a Non-transcriptional S. Chatterjee. Univ. of Pennsylvania. Regulatory Mode in 17β-Estradiol (E )-Treated Mice. 9:30 Role of NOX2 in the Microvascular Dysfunction in Type 2 D.Q. Wang, O. de Bari, H.H. Wang. Saint Louis Univ. T 1 Diabetes Mellitus. K. Matrougui. Eastern Virginia Sch. of Med. (1251.2) U Sch. of Med. 11:45 TRPV4 Modulates CYP2E1 Function in Nonalcoholic E Steatohepatitis Progression. R.K. Seth, S. Das, 472. SKELETAL MUSCLE PEROXISOMAL- D. Dattaroy, F.A. Alhasson, G.A. Michelotti, M. MITOCHONDRIAL INTERACTIONS IN HEALTH Nagarkatti, P. Nagarkatti, P.D. Bell, W.B. Liedtke, AND DISEASE A.M. Diehl, S. Chatterjee. Univ. of South Carolina, Metabolon Inc., Durham, Univ. of South Carolina Sch. Featured Topic of Med., Univ. of Alabama at Birmingham and Duke Univ. (1251.3) (Sponsored by: APS Muscle Biology Group) 12:00 Chronic Alcohol Consumption Alters Rhythms in Key Tue. 8:00 am—San Diego Convention Center, Room 25B Enzymes and Transcription Factors Involved in Lipid Metabolism: Potential Role of the Circadian Clock. Chaired: R. Cortright and R. Noland J.A. Valcin, U.S. Udoh, T. Swain, S.M. Bailey. Univ. 8:00 Introduction to the Topic. R. Cortright. East Carolina Univ. of Alabama at Birmingham. (1251.1) 8:15 Peroxisomal-Mitochonrial interactions in Cardiac 12:15 Mast Cells Promote Biliary Proliferation and Hepatic -/- Muscle. C. Hoppel. Case Western Reserve Univ. Fibrosis in Normal and HDC Mice by Interacting with 9:00 Peroxisomes in Skeletal Muscle Protect against Lipid- Cholangiocytes and Hepatic Stellate Cells via TGF-β1 Induced Insulin Resistance. R.C. Noland, E.A. Signaling. H. Francis. Central Texas VA Hlth. Care Worsham, J. Simon, S.E. Fuller, M. Baes, S. Ghosh, Syst./Baylor Scott & White Hlth., Temple. (1251.4) R.L. Mynatt. Pennington Biomed. Res. Ctr., Baton Rouge, Katholieke Univ. Leuven and Duke-Natl. Univ. 474. CONTEXT DEPENDENCE OF of Singapore Grad. Med. Sch. (1246.1) CARDIORESPIRATORY PHYSIOLOGY: 9:15 Energy Sensing Pathways Differentially Regulate TEMPERATURE EFFECTS, CIRCADIAN Peroxisomes in Skeletal Muscle versus Liver. S.E. CYCLES, AND SYSTEM INTERDEPENDENCE Fuller, E.A. Worsham, J. Simon, T.W. Gettys, R.L. Mynatt, R.C. Noland. Pennington Biomed. Res. Ctr., Symposium Baton Rouge. (1246.2) 9:30 Overexpression of PGC-1α Increases Peroxisomal (Sponsored by: APS Comparative and Evolutionary Biogenesis and Mitochondrial Lipid Oxidation in Physiology Section) Human Primary Myotubes. T-Y. Huang, D. Zheng, J.A. Tue. 10:30 am—San Diego Convention Center, Room 25C Houmard, J.J. Brault, R.C. Hickner, R.N. Cortright. East Carolina Univ., Diabetes Obesiy Inst. and Brody Chaired: J. Santin and L. Hartzler Sch. of Med., Greenville, NC. (1246.3) Oxidative Stress 9:45 Conclusion. Environmental Stress Neurobiology 10:30 Anurans as Research Models for Cardio-Respiratory Physiology: Classic Questions and New Directions. S. Hillman. Portland State Univ.

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11:00 Temperature Effects on the Baroreflex in toads. L. Zena. 477. LEADERSHIP AND MANAGEMENT SKILLS: UNESP, Jaboticabal, Brazil. WHAT YOU MIGHT NOT SEE IN YOUR CV 11:30 Temperature Effects on Central Chemosensitivity in Bullfrogs. J. Santin. Wright State Univ. Symposium 12:00 Orexin and the Modulation of Respiratory Control in Ectothermic . E. Maioqui. UNESP, (Sponsored by: APS Careers Opportunities in Jaboticabal, Brazil. Physiology Committee) Tue. 10:30 am—San Diego Convention Center, Room 25B 475. ION CHANNELS AND TRANSPORTERS IN Chaired: C. Schnackenberg and C. Richards-Williams HEALTH AND DISEASE Career Development Featured Topic 10:30 Developing the Leader Within You: Head, Heart and (Sponsored by: APS Cell and Molecular Gut. David Brooks. Johnson & Johnson. Physiology Section) 10:55 Discovering the Leader Within You: Where You’ve Been. Thomas Herzig. U.S. Navy, Groton, CT. Tue. 10:30 am—San Diego Convention Center, Room 25A 11:20 Translating Your Cv into An Effective Resume in the Life Chaired: D. Kravtsov and T. Thai Sciences. Andrew Green. Univ. of California, Berkeley. 11:45 Demonstrating Leadership and Management in Ion Transport Practice: Examples of Success and Errors. Patricia 10:30 Ion Transport Defects and Secretory Diarrhea. N. Molina. LSU Hlth. Sci. Ctr., New Orleans. Ameen. Yale Univ. Sch. of Med. 12:10 Panel Discussion. 11:00 An Investigational Anti-cancer Agent Synergizes with VX-809 in F508del Correction. A. Ambrosetti, Y. Fan, 478. MECHANISMS OF NEUROMUSCULAR E.F. Kirby, R.M. Riggs, X.R. Wang. Samford Univ. JUNCTION DESTABILIZATION McWhorter Sch. of Pharm. and Univ. of Alabama at AND FRAGMENTATION IN AGING Birmingham. (1224.48) SKELETAL MUSCLE 11:15 Store Operated Ca2+ Entry Suppressed TGFβ1- Smad3 Signaling Pathway in Glomerular Mesangial Cells. Symposium S. Chaudhari, W. Li, R. Ma. Univ. of North Texas Hlth. Sci. Ctr. (1224.28) (Sponsored by: APS Environmental and Exercise 11:30 The Physiological Effect of Altering Mitochondrial Physiology Section) Calcium Uptake in the Renal Cortical Collecting Duct. Tue. 10:30 am—San Diego Convention Center, Room 26 L.I. Galarza-Paez, D.C. Eaton, L. Zou, O. Al-Khalili, H. Ma, J.M. Sands, J.D. Klein, T.L. Thai. Emory Univ. Chaired: M. Jackson and R. Hepple Sch. of Med. (1224.13) 11:45 Human CLCA2 Modulates the Conductance of Ano1 by Exercise, Aging, and Disease Regulating Intracellular Calcium Level. A. Sharma, G. Skeletal Muscle Physiology Ramena, L. Premkumar, R.C. Elble. So. Illinois Univ. Sch. of Med. (1224.44) 10:30 Myofiber-Driven Mechanisms of NMJ Decline and 12:00 Marked Dysfunction in Gating Properties and Surface Impact. R. Hepple. McGill Univ. Hlth. Ctr. Expression of Podocyte TRPC6 Channels in 11:00 Role of the Perisynaptic Schwann Cell in Neuromuscular Experimental Models of Primary and Secondary Junction Maintenance and Reinnervation. Focal and Segmental Glomerulosclerosis In Vivo and R. Robitaillle. Univ. of Montreal. In Vitro. S.E. Dryer, E.Y. Kim, H. Roshanravan. Univ. 11:30 Muscle Innervation and Reactive Oxygen Species of Houston. (1224.29) Generation during Aging. M. Jackson. Univ. 12:15 Modulation of the BK Channel during Acute Spinal Cord of Liverpool. Injury Is Neuroprotective. M.C. Jacobsen, K.A. Lett, 12:00 Nerve Terminal Regrowth following Regeneration of M. Karnitsky, B.M. Arwini, J.M. Barden, J. Buttigieg. Muscle Fibers. W. Thompson. Texas A&M Univ. Univ. of Regina, Canada. (1224.42) 479. NEW INSIGHTS INTO THE ROLE OF 476. JULIUS H. COMROE, JR. DISTINGUISHED AUTOPHAGY IN CARDIAC DISEASE LECTURESHIP OF THE APS RESPIRATION SECTION Symposium (Sponsored by: APS Cardiovascular Section) Lecture Tue. 10:30 am—San Diego Convention Center, Room 23 Tue. 10:30 am—San Diego Convention Center, Room 24 Chaired: K.M. Mellor and B. Hill Mysteries and Maladies of Mitochondrial Dynamics. G. Sieck. Mayo Clin. Col. of Med. Myocardial Infarction/Heart Failure 10:30 Novel Glycogen Autophagy Mechanisms in the Diabetic Heart. L. Delbridge. Univ. of Melbourne.

146 TUESDAY PHYSIOLOGY

11:00 Insulin Regulation of Cardiac Autophagy. E.D. Abel. 12:10 Use of Patch-Clamp Analysis to Study Sodium Transport Univ. of Iowa. in Isolated Split-Open Cortical Collecting Ducts. 11:30 Mitophagy and Biogenesis in the Homeostatic A. Staruschenko. Med. Col. of Wisconsin. Intracellular Repair Response to Ischemia. R. Gottlieb. Cedars Sinai Hosp. 482. THE MIND MATTERS: PSYCHOLOGY 12:00 Role of Mitochondrial Autophagy during Pathological AS AN OVERLOOKED VARIABLE IN Hypertrophy and Heart Failure. J. Sadoshima. AUTONOMIC PHYSIOLOGY Rutgers New Jersey Med. Sch. Featured Topic 480. SHEAR STRESS-INDUCED MECHANOTRANSDUCTION IN ENDOTHELIAL (Sponsored by: APS Neural Control and Autonomic CELLS: IMPLICATIONS FOR VASCULAR Regulation Section) HEALTH AND ADAPTATIONS TO Tue. 10:30 am—San Diego Convention Center, Room 28A PHYSICAL ACTIVITY Chaired: E. Wehrwein and J. Carter

Symposium Environmental Stress (Sponsored by: APS Cardiovascular Section) Hypertension

Tue. 10:30 am—San Diego Convention Center, Room 22 Neurophysiology

Chaired: Y. Hellsten and S. Egginton 10:30 Psychophysiology: The Influence of Personality and State of Mind in Autonomic Neural Control and T Barriers: Endothelium and Epithelium Cardiovascular Reactivity Studies. J. Moser. Michigan U Exercise, Aging, and Disease State Univ. 10:45 Renal Pelvic Afferent Nerves Are Responsible for E 10:30 Microvascular Response to Altered Endothelial Greater Resting and Evoked Vasoconstrictor Tone Phenotype in High and Low Shear Environments. in Individual Rats. M.M. Knuepfer, N.B. Hoffman- S. Egginton. Univ. of Leeds. Schepers, J.L. Perry. St. Louis Univ. Sch. of Med. 11:00 Response of the Arterial Vascular Tree to Shear (1238.1) and Consequences for Vascular Remodeling. 11:00 Cardiovascular and Behavioral Sequelae of Witnessing M. Laughlin. Univ. of Missouri Sch. of Med. Social Defeat Stress in Male and Female Rats. C.M. 11:30 Molecular Regulation of Shear Stress-Induced Lombard, M.N. Melson, J.R. Fadel, C.S. Wood, S.K. Mechanotransduction in Man. L. Gliemann. Univ. Wood. Univ. of South Carolina Sch. of Med. (1238.3) of Copenhagen. 11:15 Impaired Autonomic Regulation in Posttraumatic 12:00 Shear Stress Modulation of Crosstalk between Stress Disorder. A.P. Swiercz, J. Park, L. Hopkins, Endothelial Cells and Skeletal Myocytes. T. Haas. C. Moshfegh, J. Wiaderkiewicz, C.N. Young, P.J. Univ. of York, Toronto. Marvar. George Washington Univ. and Emory Univ. (1238.7) 481. STILL UNRAVELING THE MYSTERIES OF THE 11:30 Baroreflex Dysfunction and Augmented Sympathetic KIDNEY WITH ISOLATED TUBULES AFTER ALL Nerve Responses during Combat-Related and THESE YEARS Noncombat-Related Mental Stress in Veterans with Post-Traumatic Stress Disorder. J. Park, P.J. Marvar, Symposium P. Liao, M.L. Jefferson, B.O. Rothbaum. Emory Univ., Atlanta VA Med. Ctr., Decatur and George (Sponsored by: APS Renal Section) Washington Univ. (1238.8) Tue. 10:30 am—San Diego Convention Center, Room 27 11:45 Oxidative Stress Contributes to Microvascular Endothelial Dysfunction in Humans with Major Chaired: J.M. Sands and H.L. Brooks Depressive Disorder. J.L. Greaney, L. Santhanam, Transporters/Channels/Barriers E.F. Saunders, L.M. Alexander. Penn State, Johns Hopkins Univ. Sch. of Med. and Penn State Col. of 10:30 History of the Development of Tubule Perfusion. Med. (1238.9) M. Burg. NHLBI, NIH. 12:00 Slow Breathing Reductions in Mean Arterial Pressure 10:55 Use of Adenovirus-Mediated Gene Transfer and Are Dependent on Psychological Characteristics. Microscopy to Study NaCl Transport and Signaling in K.L. Kelly, J. Lin, J.M. Poteracki, K.M. Adams, C.A. the Perfused Thick Ascending Limb. G. Ares. Henry Kelly, B.J. Wegner, L.P. Newhouse, J.S. Moser, E.A. Ford Hosp. Wehrwein. Michigan State Univ. (1238.11) 11:20 Use of Knock-Out Mice and Electron Microscopy to 12:15 Does Trait Anxiety Influence Muscle Sympathetic Nerve Study Chloride and Bicarbonate Transport in Perfused Activity Responsiveness in Humans? J.R. Carter, I.T. Cortical Collecting Ducts. S. Wall. Emory Univ. Fonkoue. Michigan Technol. Univ. (1238.12) 11:45 Use of Perfused Tubules and 3-D Digital Models of the Renal Medulla to Study the Urine Concentrating Mechanism. T. Pannabecker. Univ. of Arizona.

147 PHYSIOLOGY TUESDAY

483. HISTORY OF PHYSIOLOGY LECTURE 4:45 High Salt Intake Alters Renal Medullary Clock Genes

via ETB Receptors. J.S. Speed, K.A. Hyndman, M. Lecture Kasztan, J.G. Johnston, K.J. Roth, M.E. Young, J.S. Pollock, D.M. Pollock. Univ. of Alabama at (Sponsored by: APS History of Physiology Group) Birmingham. (1216.9)

Tue. 1:00 pm—San Diego Marriott Marquis & Marina 5:00 Role of Kir5.1 (Kcnj16) Channel in the Control of Hotel, Marina Ballroom DE Potassium Homeostasis in the Kidney. O. Palygin, V. Levchenko, A. Geurts, A. Staruschenko. Med. Col. Rediscoveries of Oxygen. J. Severinghaus. UCSF Sch. of Wisconsin. (1216.16) of Med. 487. AUGUST KROGH DISTINGUISHED 484. ROBERT M. BERNE DISTINGUISHED LECTURESHIP OF THE APS COMPARATIVE LECTURESHIP OF THE APS AND EVOLUTIONARY PHYSIOLOGY SECTION CARDIOVASCULAR SECTION Lecture Lecture (Supported by Novo Nordisk Foundation) Tue. 2:00 pm—San Diego Convention Center, Room 24 Tue. 3:15 pm—San Diego Convention Center, Room 23 Oh, the Places You’ll Go! My Many Colored Serotonin (Apologies to Dr. Seuss). S. Watts. Michigan State Univ. Environmental Stress Oxidative Stress 485. TANG PRIZE IN BIOPHARMACEUTICAL Physiological and Evolutionary interactions among SCIENCE AWARD LECTURE Body Size, Metabolic Rate and Oxygen. J. Harrison. Arizona State Univ. Lecture (Sponsored by: Tang Prize Foundation) 488. GENE REGULATION IN SKELETAL MUSCLE

Tue. 3:00 pm—San Diego Convention Center, Room 33BC Symposium Cancer Immunotherapy by PD-1 Antibody. T. Honjo. (Sponsored by: APS Muscle Biology Group) Kyoto Univ. Grad. Sch. of Med. Tue. 3:15 pm—San Diego Convention Center, Room 25C

486. CROSS-TALK BETWEEN SALT AND OTHER Chaired: G. Nader FACTORS IN HYPERTENSION 3:15 Nuclear Receptors and Exercise Mimetics: Running Featured Topic around Physiology. R. Evans. Univ. of Kentucky. 3:45 Muscle Gene Control Elements Exhibit Differential (Sponsored by: APS Water and Electrolyte Transcriptional Activities in Skeletal Muscle Fiber Homeostasis Section) Types, Cardiac Muscle, and Non-muscle Tissue Types. S. Hauschka. Univ. of Washington. Tue. 3:15 pm—San Diego Convention Center, Room 26 4:15 Alternative Splicing Transitions during Postnatal Chaired: N. Li Skeletal Muscle Development Contribute to Adult Muscle Function. T. Cooper. Baylor Coll. of Medicine. 3:15 Interaction between Dietary Fructose and Salt in 4:45 Delineating Gene Regulatory Circuitry Controlling the Regulation of Blood Pressure. P. Ortiz. Henry Muscle Fitness. D. Kelly. Sanford-Burnham Med. Ford Hosp. Res. Inst. 3:45 Inhibition of Hypoxia Inducible Factor-1α in the Renal Medulla Contributes to Fructose-Induced Salt- Sensitive Hypertension. J. Hu, Q. Zhu, P-L. Li, K.M. 489. HORACE W. DAVENPORT DISTINGUISHED Boini, N. Li. Virginia Commonwealth Univ. (1216.2) LECTURESHIP OF THE APS 4:00 High Salt Activates Human Monocytes and Promotes GASTROINTESTINAL AND LIVER Their Conversion into Dendritic Cells via Formation PHYSIOLOGY SECTION of Immunogenic Isoketal-Adducts. A. Kirabo, N. Barbaro, J.D. Foss, K.R. Montaniel, W. Chen, D.G. Lecture Harrison. Vanderbilt Univ. Med. Ctr. (1216.4) Tue. 3:15 pm—San Diego Convention Center, Room 24 4:15 Deletion of Rag1 Prevents High Dietary Protein-Induced Exacerbation of Hypertension and Renal Injury in Dahl Barriers: Endothelium and Epithelium SS Rats. J.M. Abais-Battad, H. Lund, D.L. Mattson. The intermediate Filament Cytoskeleton: From Bench to Med. Col. of Wisconsin. (1216.3) Bedside. B. Omary. Univ. of Michigan. 4:30 Modulation of Salt and Mineralocorticoid Sensitivity of Blood Pressure by the Circadian Clock Protein Per1. K. Solocinski, X. Wen, K-Y. Cheng, J. Lynch, C.S. Wingo, B.D. Cain, M.L. Gumz. Univ. of Florida and NF/SG Veterans Hlth. Syst. (1216.10)

148 TUESDAY PHYSIOLOGY

490. HORMONES AND REPRODUCTION 492. MECHANISMS REGULATING SKELETAL MUSCLE MASS Featured Topic Featured Topic (Sponsored by: APS Endocrinology and Metabolism Section) (Sponsored by: APS Environmental and Exercise Physiology Section) Tue. 3:15 pm—San Diego Convention Center, Room 25B Tue. 3:15 pm—San Diego Convention Center, Room 28A Chaired: W. Samson Chaired: S.C. Bodine Neurobiology Exercise, Aging, and Disease Neurophysiology Skeletal Muscle Physiology 3:15 Novel Peptide/Receptor Interaction Controlling Reproduction. L. Stein. Saint Louis Univ. 3:15 TGF and BMP Signaling in Skeletal Muscle and the 3:45 Hypothalamic Circuits Controlling Reproductive Regulation of Muscle Mass. P. Gregorevic. Baker IDI Hormone Secretion. D. Belsham. Univ. of Toronto. Heart and Diabetes Inst., Melbourne, Australia. 4:15 Estrogen Treatment Restores Muscle Mitochondrial 3:45 Mechanotransduction and the Regulation of Function and Redox Homeostasis, Reversing the Skeletal Muscle Mass. T. Hornberger. Univ. Pro-diabetogenic State Induced by Ovariectomy. M.J. of Wisconsin-Madison. Torres, L. Reese, C. Smith, E. Pennington, T. Ryan, 4:15 Multiple Tripartite Motif E3 Ubiquitin Ligases Facilitate R. Shaikh, P.D. Neufer. East Carolina Diabetes and Skeletal Muscle Atrophy. H. Manring, E.M. Smith, Obesity Inst., East Carolina Univ. (1247.1) E.X. Beck, K.E. McElhanon, L. Gushchina, W.A. He, T 4:30 Artificial Synchronization of Ovarian Hormones in Early D.C. Guttridge, N. Weisleder. The Ohio State Univ. U Pregnancy Improves Adverse Pregnancy Outcomes (1244.9) Associated with Preeclampsia in the BPH/5 Mouse 4:30 Postnatal Muscle Growth Is Dependent on Satellite E Model. J.L. Sones, A.K. Woods, J. Cha, S.K. Dey, Cell Proliferation Which Demonstrates a Specific R.L. Davisson. Cornell Univ. and Cincinnati Children’s Requirement for Dietary Protein. M.L. Fiorotto, D.A. Res. Fndn. (1247.4) Columbus, J. Steinhoff-Wagner, A. Suryawan, 4:45 Association between Hormonal Contraceptive Use and H.V. Nguyen, T.A. Davis. USDA, Baylor Col. of Med. Prevalence of Premenstrual Symptoms. A.C. Jarosz, (1244.1) J. Jamnik, A. El-Sohemy. Univ. of Toronto. (1247.5) 4:45 Contribution of Satellite Cells to Skeletal Muscle 5:00 Polycystic Ovary Syndrome Phenotype in Proteostasis during Advanced Age and Aerobic Hyperinsulinemic but Normoandrogenic Monosodium Exercise. A.R. Konopka, S.E. Ehrlicher, K.A. L-Glutamate Obese Rats. R.S. Gaspar, R.O.A. Baeverstad, J. Reid, F.F. Peelor III, A.L. Confides, Benevides, J.L. Fontelles, C.C. Vale, L.M. França, E.E. Dupont-Versteegden, B.F. Miller, K.L. A.M.A. Paes. Fed. Univ. of Maranhão, Brazil. (1247.6) Hamilton. Colorado State Univ. and Univ. of Kentucky Col. of Hlth. Sci. (1244.2) 491. ION, WATER, AND GAS MOVEMENTS THROUGH 5:00 Leucine Modulates mTORC1 Signaling by Acting THE BRAIN IN HEALTH AND DISEASE: Specifically to Alter the Phosphorylation Status of PUTTING IT ALL TOGETHER Sestrin2. S.R. Kimball, B.S. Gordon, J.E. Moyer, M.D. Dennis, L.S. Jefferson. Penn State Col. of Med. Symposium and Univ. of Central Florida. (1244.3)

(Sponsored by: APS Cell and Molecular 493. MECHANOBIOLOGY OF FIBROSIS ACROSS Physiology Section) ORGAN SYSTEMS Tue. 3:15 pm—San Diego Convention Center, Room 25A Symposium Chaired: M.E. O’Donnell and J.J. Iliff Tue. 3:15 pm—San Diego Convention Center, Ballroom 20A Transporters/Channels/Barriers Chaired: D. Tschumperlin Barriers: Endothelium and Epithelium Inflammation/Immunity Ion Transport 3:15 Mechanobiology in Liver Fibrosis: Implications for 3:15 Role of Blood Brain Barrier Ion Transporters and Fibrosis Progression and Regression. R. Wells. Univ. Channels in Brain Edema Formation. M. O’Donnell. of Pennsylvania. Univ. of California. 3:55 Targeting Cytoskeletal/Mechanical Signaling Pathways 3:45 Aquaporins as Gas Channels. W. Boron. Case Western in Fibrosis. R. Neubig. Michigan State Univ. Reserve Univ. 4:35 Novel Tools to Image and Target the Extracellular Matrix. 4:15 The Glymphatic System. J. Iliff. Oregon Hlth. & Sci. Univ. T. Barker. Georgia Tech. 4:45 Role of Aquaporins in Brain injury. J. Badaut. Univ. of Bordeaux.

149 PHYSIOLOGY TUESDAY

494. METABOLIC REGULATION OF CARDIAC Disease. B. Smith. Univ. of Florida. FUNCTION IN DIABETES: EPIGENETICS AND 4:45 Spinal Stimulation as a Rehabilitative Tool to Restore POSTTRANSLATIONAL MECHANISMS Respiratory Motor Output after Spinal injury. E. Gonzalez-Rothi. Univ. of Florida. Featured Topic 496. NOVEL MECHANISMS AT THE LEVEL OF THE (Sponsored by: APS Cardiovascular Section) SOLITARY TRACT NUCLEUS (NTS) Tue. 3:15 pm—San Diego Convention Center, Room 22 Featured Topic Chaired: A. Wende and J. Chatham (Sponsored by: APS Central Nervous System Section) Myocardial Infarction/Heart Failure Tue. 3:15 pm—San Diego Convention Center, Room 27 Diabetes, Metabolic Syndrome Chaired: S. McDougall 3:15 O-GlcNAcylation at the Interface of Cardiac Responses to Exercise and Nutrient Excess. S. Marsh. Neurobiology Washington State Univ. Hypertension 3:15 Glucose-Mediated Regulation of UQCRFS1 and the Cardiac Metabolome. L.J. Williams, M.K. Brahma, Neurophysiology M.M. McCrory, A.R. Wende. Univ. of Alabama at 3:15 Spontaneous Neurotransmission in the NTS Conveys Birmingham. (1273.10) Circuit State. J. Peters. Washington State Univ. 3:15 Cardiomyocyte Glucose Handling Is Influenced by 3:45 Inflammation Increases the Excitatory Synaptic β-Adrenergic and AMPK Regulation of Glycogen and Transmission in the Nucleus Tractus Solitarius of Rats Autophagy in Metabolic Stress Settings. K.M. Mellor, Submitted to Sustained Hypoxia. L. Lima Silveira, U. Varma, E. Stevens, L.M.D. Delbridge. Univ. of D. Accorsi-Mendonca, L.G.H. Bonagamba, B.H. Auckland and Univ. of Melbourne. (1273.8) Machado. Univ. of São Paulo, Ribeirão Preto. 3:15 CaMKIId as a Nodal Mediator of Insulin Signaling (1232.5) and Adrenergic Signaling in Cardiomyocytes – a 4:00 GABA Transporters within the Nucleus Tractus Solitarii Signaling Network Map Profiling by Quantitative Modulate GABAergic Signaling, Neuronal Activity and Phospho-proteomics. S. Dewan, A. Campos, S. Wu, Cardiorespiratory Function. M.P. Matott, E.M. Hasser, J. Stowe, A. Wolf, D.M. Bers, L.M. Brill, J.H. Brown, D.D. Kline. Univ. of Missouri-Columbia. (1232.4) A. McCulloch. UCSD, Sanford Burnham Med. Res. 4:15 Adult Neurogenesis in the NTS: A Role in Hypertension? Inst., La Jolla and Univ. of California, Davis. (1273.3) Song Yao. Florey Inst., Parkville, Australia. 3:15 Anti-diabetic Effects of Class 1 Histone Deacetylase 4:45 High Fat Diet Induced Inhibition of Sympathetic Outflow Inhibition in a Rodent Model of Type 2 Diabetes to Brown Adipose Tissue: Role of the Nucleus Tractus Mellitus. E. Johnson, S. Marsh. Washington State Solitarius. C.J. Madden, S.F. Morrison. Oregon Hlth. Univ. (1273.6) & Sci. Univ. (1232.2) 3:15 Metabolomics Meets Epigenetics: Posttranslational 5:00 Dysfunction of Astrocytes in the Nucleus Tractus Remodeling of the Chromatin Structure. J. Hanover. Solitarii Leads to Cardiorespiratory Compromise. W.T. NIH, NIDDK. Talman, L-H. Lin, S. Jones, D.N. Dragon, Y. Wu, G.B. Richerson. Univ. of Iowa and VA Med. Ctr. (1232.3) 495. NEUROSTIMULATION TO RESTORE BREATHING WITH NEUROMUSCULAR DISORDERS 497. APS BUSINESS MEETING Symposium Business Meeting (Sponsored by: APS Respiration Section) Tue. 5:45 pm—San Diego Convention Center, Ballroom 20A Tue. 3:15 pm—San Diego Convention Center, Room 28B

Chaired: G.S. Mitchell and K. Streeter

Neurobiology Neurophysiology 3:15 Spinal Cord Stimulation for Restoring Mobility after Spinal Cord injury. V. Mushahwar. Univ. of Alberta. 3:45 Diaphragm Pacing as a Rehabilitative Tool to Restore Breathing Capacity in Individuals with SCI. E. Fox. Univ. of Florida. 4:15 Diaphragm Pacing as a Rehabilitative Tool to Restore Breathing Capacity in Individuals With Pompe

150 WEDNESDAY, APRIL 6 Biochemistry and Molecular Biology

498. ASBMB PLENARY LECTURE 10:15 Radical SAM Enzyme-Catalyzed Formation of Thioether Crosslinks in Ribosomal-Produced Peptides: Plenary Formation of the RiPP Natural Product Thuricin CD by the Radical Sam Enzymes TrnC and TrnD. J.T. Jarrett, C.E. Wed. 8:00 am—San Diego Convention Center, Room 6D Holjencin. Univ. of Hawaii at Manoa. (1084.2) 8:00 Awardee Introduction. 10:30 501.2 Capturing a Cryptic Biosynthetic Intermediate 8:05 498.1 Regulation of Gene Expression by Complex Reveals Novel Enzyme Functions in Molybdenum Cofactor RNA Molecules. A.M. Pyle. Yale Univ., HHMI. Biosynthesis. K. Yokoyama, B.M. Hover, N.K. Tonthat, M.A. Schumacher. Duke Univ. Med. Ctr. 499. ASBMB PLENARY LECTURE 10:55 Structure of a Key Intermediate in the Reaction Catalyzed by the Dual Specificity Methylase RlmN. E.L. Schwalm, Plenary T. Grove, A. Boal, S. Booker. Penn State and HHMI. (1085.1) 11:10 Sifting through the Haystack to Find the Needle: Wed. 8:45 am—San Diego Convention Center, Room 6D Spatial Identification of a Structural Conduit for Transfer of Thermal Activation Energy in the Course of C-H Cleavage in 8:45 Awardee Introduction. Soybean Lipoxygenase. A. Offenbacher, S. Hu, A. Nguy, A. 8:50 499.1 Physical Mechanisms of Cell Organization Iavarone, J. Klinman. Univ. of California, Berkeley. (1086.1) on Micron Length Scales. M.K. Rosen. Univ. of Texas 11:25 501.3 Structural Basis for Divergent Reaction Outcomes Southwestern Med. Ctr., HHMI. in Iron(II)/2OG-Dependent Oxygenases. A. Boal. Penn State 11:50 Discussion. 500. REPAIR DURING DNA REPLICATION 502. PROTEIN DEGRADATION IN HEALTH W Symposium AND DISEASE E Wed. 9:45 am—San Diego Convention Center, Room 1B D Symposium Chaired: J.M. Berger Wed. 9:45 am—San Diego Convention Center, Room 1A Follow the conversation: #DNA Chaired: C. Joazeiro 9:45 Chair’s Introduction. 9:50 500.1 DNA Repair during DNA Replication. D. Follow the conversation: #proteins Cortez. Vanderbilt Univ. Sch. of Med. 10:15 Early Replication Stress Leads to Abnormal 9:45 Chair’s Introduction. Mitosis and Genome Rearrangement. S. Forsburg. Univ. of 9:50 502.1 Dissection and Reconstitution of Autophagic So. California. (793.4) Membrane Fusion. Q. Zhong, J. Diao, R. Liu, Y. Rong. Univ. of 10:30 500.2 Molecular Mechanism of DNA Interstrand Texas Southwestern Med. Ctr. and Stanford Univ. Crosslink Repair. A. Smogorzewska, M. Kottemann, B. Conti, 10:15 A High-Content RNAi Screen to Elucidate S. Thongthip, K. Rickman, F. Lach. The Rockefeller Univ. Novel Effectors of Cardiac Proteotoxicity. P.M. McLendon, 10:55 A Nucleolar Role for the Fanconi Anemia G. Davis, J. Gulick, K. Shay-Winkler, J.D. Molkentin, J. Pathway Protein, FANCI, in rDNA Transcription. S.B. Sondalle, Robbins. Cincinnati Children’s Hosp. Med. Ctr. (1063.3) S. Longerich, P. Sung, S.J. Baserga. Yale Univ. (1048.1) 10:30 502.2 Twists and Turns in Ubiquitin Conjugation 11:10 Multiple Invasions-Induced Chromosomal Cascades. B. Schulman. St. Jude Children’s Res. Hosp. Rearrangements. A. Piazza, W-D. Heyer. Univ. of California, 10:55 An Inherited Developmental Disorder Reveals Davis. (576.2) Functions for WHAMM and the Actin Nucleation Machinery in 11:25 500.3 Chromatin Replication and Epigenome Early Stages of Autophagy. K. Campellone, A. Mathiowetz, A. Maintenance. A. Groth. BRIC, Univ. of Copenhagen. Russo, E. Baple, A. Crosby. Univ. of Connecticut and Univ. of 11:50 Discussion. Exeter Med. Sch. (1064.2) 11:10 APOBEC3F-Vif Binding Interface Elucidated by Multiple Experimental Approaches. R. Harris, C. Richards, 501. RADICALS IN CATALYSIS N. Shaban, B. Anderson, O. Demir, R. Amaro. Univ. of Minnesota and HHMI, Minneapolis and UCSD. (1069.1) Symposium 11:25 502.3 Ubiquitin and ISG15 Conjugation at the Wed. 9:45 am—San Diego Convention Center, Room 6C Ribosome. J. Huibregtse, L. Canadeo, C. Swaim, H. O’Connor. Univ. of Texas at Austin. Chaired: C. Krebs 11:50 Discussion. Follow the conversation: #catalysis 9:45 Chair’s Introduction. 9:50 501.1 Enzymes Involved in Secondary Metabolism and RNA Modification. V. Bandarian. Univ. of Utah.

151 BIOCHEMISTRY WEDNESDAY

503. BIOCHEMICALLY-INFORMED IMAGING IN 505. BEYOND THE BENCH: MAXIMIZING GRADUATE/ DRUG DISCOVERY POSTDOCTORAL TRAINING FOR NON- RESEARCH STEM CAREERS Symposium Symposium Wed. 9:45 am—San Diego Convention Center, Room 6E (Sponsored by: ASBMB Minority Affairs Committee) Follow the conversation: #metabolism Wed. 12:30 pm—San Diego Convention Center, Room 6A 9:45 Chair’s Introduction. 9:50 503.1 Exploiting the Biology of Trehalose to Develop Chaired: S. Blatch Novel Imaging Probes for Tuberculosis. C. Barry. NIAID, NIH. 10:15 Targeting Peptide Bound to Major 12:30 Chair’s Introduction. Histocompatibility Complex Allows Visualization of Insulin Secreting 12:30 505.1 To Stay (at the Bench) or Go? Determinants Beta Cells In Vivo. K.R. Miller, J. Taft, A. Koide, M. Johnson, R. of Career Decision-Making in Recent PhD Graduates. K.D. Tisch, S. Koide, E. Collins. Univ. of Mount Union, Univ. of Chicago Gibbs, K. Griffin. NCI, NIH and Univ. of Maryland College Park. and Univ. of North Carolina at Chapel Hill. (1098.2) 12:30 505.2 Finding Your Fit among Career Options with a 10:30 503.2 Imaging Mass Spectrometry – The PhD. R. McGee. Northwestern Univ. Pyrazinamide Enigma. B. Prideaux, J. Sarathy, L. Via, P. 12:30 505.3 Science Policy: Making a Big Difference Gopal, C. Barry, T. Dick, V. Dartois. New Jersey Med. Sch., in the Future of Discovery. D.R. Wilson. Indian Hlth. Svc., Rutgers Univ., NIAID, NIH and Natl. Univ. of Singapore. Rockville, MD. 10:55 Sequestration-Mediated Downregulation of de 12:30 Discussion. Novo Purine Biosynthesis by AMPK. D.L. Schmitt, S. An. Univ. of Maryland Baltimore County. (850.9) 506. BACTERIAL GLYCOSYLATION AND 11:10 Effects of Synthetic Ligands on Heterodimer THE MICROBIOME Pairs Regarding PPARα, RXRα and LXRα. E.E. Delman, S.D. Rider, H.A. Hostetler. Wright State Univ. (630.1) Symposium 11:25 503.3 Fluorogenic Probes for Detecting Mycobacterial Hydrolases. K. Beatty, S. Levine, K. Tallman. Oregon Hlth. & Wed. 2:15 pm—San Diego Convention Center, Room 1A Sci. Univ. Chaired: J. Kohler 11:50 Discussion. Follow the conversation: #glyco 504. LIPIDS AND ENERGY METABOLISM 2:15 Chair’s Introduction. 2:20 506.1 Human Gut Bacteroidetes. H. Gilbert. Symposium Newcastle Univ., U.K. 2:45 Lectin Nucleotide Phosphohydrolases May Wed. 9:45 am—San Diego Convention Center, Room 6F Function as Co-receptors or Modulators of Several Chitin- Chaired: K.M. Reinisch Based Oligosaccharide Signaling Events in Plants. M.E. Etzler, N. Roberts, G. Kalsi. Univ. of California, Davis, AgRes. Follow the conversation: #lipids Grasslands Res. Ctr., New Zealand and ITC Ltd., Bengaluru, 9:45 Chair’s Introduction. India. (847.2) 9:50 504.1 Regulation and Function of Fatty Acid 3:00 506.3 Proteins and Carbs – The Balanced Diet of a Desaturases. J. Ntambi, M.S. Burhans, C-A. Guo, L.M. Bond. Complex and Unusual Enzyme Family. A. Boraston, I. Noach, Univ. of Wisconsin-Madison. E. Ficko-Blean, C. Stuart, D. Brochu, M. Gilbert. Univ. of 10:15 Multifaceted Regulation of Hepatic G0/G1 Victoria, Canada and Natl. Res. Council Canada, Ottawa. Switch Gene 2 Expression and Relevance to Lipid Metabolism. 3:25 Bacterial Glycosidases Acting on Red Blood B. Heckmann, X. Zhang, A. Saarinen, J. Liu. Mayo Clin., Cells. Y. Bourne, G. Ponchel, V. Roig-Zamboni, E.P. Bennett, Scottsdale. (1134.4) B. Henrissat, H. Clausen, G. Sulzenbacher. CNRS, Aix- 10:30 504.2 A Potential Mediator of Diabetes-Associated Marseille Univ. and Copenhagen Ctr. for Glycomics. (843.5) Cardiovascular Disease: The Enzyme FMO3. S. Biddinger. 3:40 Bacterial Cell Wall Remodeling to Study the Boston Children’s Hosp. Production of Immunoactivating Fragments. H. Liang, K.E. 10:55 A Novel Mouse Model with Targeted and Inducible DeMeester, C-W. Hou, C.L. Grimes. Univ. of Delaware. Deletion of Intestinal CTP:Phosphocholine Cytidylyltransferase α. (1095.3) J.P. Kennelly, J. van der Veen, R. Nelson, R. da Silva, K. Kelly, 3:55 506.5 Interactions between Campylobacter jejuni and K. Leonard, S. Wan, R. Jacobs. Univ. of Alberta. (1134.6) AB5 in the Gut. C.M. Szymanski, R.T. Patry, M. Stahl, 11:10 Evidence of a Perilipin-5 Splice Variant. B.L. J.C. Sacher, B.A. Vallance. Complex Carbohydrate Res. Ctr., Ranzau, D.M. DuBreuil, T. Hubbell, J.T. Tansey. Otterbein Athens, GA, BC Children’s Hosp., Univ. of British Columbia Univ. (1134.7) and Univ. of Alberta. 11:25 504.3 Discovery of a Novel Class of Naturally-Occurring 4:20 Discussion. Lipids with Anti-diabetic and Anti-inflammatory Effects. B. Kahn, M.M. Yore, I. Syed, P.M. Moraes-Vieira, T. Zhang, M.A. Herman, E. Homan, J. Lee, S. Chen, O.D. Peroni, A. Hammarstedt, R. Patel, T.E. McGraw, U. Smith, A. Saghatelian. Beth Israel Deaconess Med. Ctr. and Harvard Med. Sch. 11:50 Discussion.

152 WEDNESDAY BIOCHEMISTRY

507. NON-CODING RNA AND GENE REGULATION 509. MOLECULAR CROSSTALKS OF MULTIPLE CONSORTIA Symposium Symposium Wed. 2:15 pm—San Diego Convention Center, Room 1B Wed. 2:15 am—San Diego Convention Center, Room 6D Chaired: J.Q. Svejstrup Chaired: O. Lichtarge Follow the conversation: #chromatin Follow the conversation: #proteomics 2:15 Chair’s Introduction. 2:20 507.1 Genome Regulation by Long Noncoding 2:15 Chair’s Introduction. RNAs. H.Y. Chang. Stanford Univ. Sch. of Med. 2:20 509.1 Multi-omics of the Soil Microbiome. J.K. 2:45 Transfer RNA Fragments: A Novel Class of Jansson. Pacific Northwest Natl. Lab., Richland, WA. Non-micro Short RNAs That Uses Ago1, 3 and 4 to Repress 2:45 Syntrophic Metabolism of Vitamins and Amino Specific Target RNAs through 5’ Seed Sequences. A. Dutta, P. Acids in Gut Microbial Community as Revealed by In Silico Kumar, M. Kiran, C. Kuscu. Univ. of Virginia. (1054.5) Genomic Analyses. M.S. Khoroshkin, D. Rodionov. IITP, 3:00 507.2 The Primary Target of Let-7 MicroRNA. Russian Acad. of Sci., Moscow and Sanford Burnham Prebys A. Pasquinelli. UCSD. Med. Discovery Inst., San Diego. (819.5) 3:25 A Specialized Mechanism of MicroRNA- 3:00 509.2 Metabolic Exchange in Microbial Communities. Mediated Translation in Quiescence. S. Vasudevan, S.I.A. A. Osterman. Sanford Burnham Prebys Med. Discovery Inst., Bukhari, S.S. Truesdell, S. Lee, S. Kollu, A. Classon, M. La Jolla. Boukhali, E. Jain, A. Yanagiya, R. Sadyrev, W. Haas. MGH- 3:25 Evolutionary and Comparative Genome Harvard Med. Sch. and McGill Univ. (1054.6) Analysis of Phage NAD Metabolic Genes. L. Sorci, M.D. 3:40 NURF Localizes in Gene Bodies to Regulate Kazanov, S. Gerdes. Marche Polytech Univ., Italy, Russian mRNA Processing. J. Landry, A. Alhazmi, M. Mack, A. Acad. of Sci., Moscow and Argonne Natl. Lab., IL. (819.15) Petencin, H. Nelson, J. Hiegel, V. Koparde, N. Scarsdale, C. 3:40 Integrating Reductive and Synthetic Lyons, M. Dozmorov. Virginia Commonwealth Univ. (1053.1) Approaches in Biology Using Man-Made Cell-Like 3:55 507.3 Enhancer Transcription and Enhancer Compartments. W. Aoki, S. Komura, E. Tamiya, M. Ueda. W Function. C. Glass, D. Gosselin, V. Link, C.E. Romanoski, T. Kyoto Univ. and Osaka Univ. (1074.1) Troutman, M. Lam, D. Eichenfeld. UCSD. 3:55 509.3 How Antibiotics Affect the Human Gut E 4:20 Discussion. Microbiome: Lessons from the Extreme. J. Xavier. Mem. D Sloan-Kettering Cancer Ctr. 508. CHEMISTRY, BIOLOGY, AND SUSTAINABILITY 4:20 Discussion.

Symposium 510. TUMOR SUPPRESSORS/TUMOR DRIVERS

Wed. 2:15 pm—San Diego Convention Center, Room 6C Symposium

Chaired: J. Jez Wed. 2:15 pm—San Diego Convention Center, Room 6E

Follow the conversation: #chembio Chaired: S. Malek 2:15 Chair’s Introduction. Follow the conversation: #cellsignal 2:20 508.1 The Future of Biobased Chemicals. B. Shanks. 2:15 Chair’s Introduction. Iowa State Univ. 2:20 510.1 Reversing the Paradigm: Protein Kinase C as 2:45 A Novel Thermotolerant β-Glucosidase from a Tumor Suppressor. A. Newton. UCSD. Aspergillus nidulans Has Activity across a Broad pH Profile 2:45 Ceramide Is a Key Factor That Regulates the and a Likely Bacterial Origin. R. Auta, I. Radecka, P. Hooley. Crosstalk between TGF- and Sonic Hedgehog Signaling at the Univ. of Wolverhampton, U.K. and Kaduna State Univ., Nigeria. β Basal Cilia to Control Cell Migration and Tumor Metastasis. S. (1070.1) Gencer, N. Oleinik, M. Dany, B. Ogretmen. Med. Univ. of South 3:00 508.2 Engineering Microbial Fatty Acid Biosynthesis Carolina and Uskudar Univ. and Abdullah Gul Univ., Turkey. (1108.2) as an Industrial Biotechnology Platform. A. Schirmer. REG 3:00 510.2 DNAJB1-PKRACA – A Novel PKA Fusion Life Sci., South San Francisco. Protein That Drives Fibrolamellar Hepatocellular Carcinoma. 3:25 Optimization and Lipid Quantitation of Potential S. Simon. The Rockefeller Univ. Algal Biofuels Feedstocks. S.J. Brad, B.E. Umbach, E.D. 3:25 HER2+ Breast Cancer Metastasis Mediated by Gehlhausen, C.R. Sweet. U.S. Naval Acad., Annapolis. (838.5) E2F2 Copy Number Changes. E. Andrechek. Michigan State 3:40 Comparison of Stability and Kinetic Properties Univ. (1108.3) of DszB from N. asteroides A3H1 and R. erythropolis IGTS8. 3:40 Exosomes Secreted by Inflammatory Cytokine A. Hutchinson-Lundy, A. Crithary, J.M. Schmitz, L. Watkins. Stimulated Glioma Cells Carry a Repertoire of Proteins Which James Madison Univ. (1087.2) Influence Progression of Glioblastoma Multiforme. R.A. Kore, E.C. 3:55 508.3 Expanding the Boundaries of Biocatalysis. Abraham, R.J. Griffin. Univ. of Arkansas for Med. Sci. (1108.16) H. Zhao. Univ. of Illinois at Urbana-Champaign. 3:55 510.3 Dysfunctional PKA Drives Diverse Disease 4:20 Discussion. Phenotypes. S.S. Taylor, J. del Rio, J. Bruystens, G. Veglia, E. Stefan, R. Ilouz, P. Zhang. UCSD, Univ. of Minnesota, Minneapolis and Univ. of Innsbruck, Austria. 4:20 Discussion.

153 NUTRITION/PATHOLOGY WEDNESDAY Nutrition

511. ASN SPONSORED SATELLITE 4TH GLOBAL 8:35 Panel: Cross-sector Solutions to Obesity in SUMMIT ON THE HEALTH EFFECTS OF YOGURT Communities, Health Care and Evalutation. P. Schwartz. Kaiser Permanente. ASN Satellite 8:40 Panel: Cross-sector Solutions to Obesity in Communities, Health Care and Evalutation. N. Pronk. (Organized and Sponsored by: Danone Institute HealthPartners, Inc. International and the American Society for Nutrition) 8:45 Functional Roles for Public-private Partnerships to

Wed. 8:00 am—San Diego Convention Center, Support Food and Nutrition Research. C. Woteki. Room 33ABC USDA, Washington DC. 9:00 Functional Roles for Public-private Partnerships to For more information on ASN Sponsored Satellite Support Food and Nutrition Research. P. Stover. Programs, please visit http://scientificsessions.nutrition.org/ Cornell Univ. satellitesessions/. 9:15 Principles for Building Public-private Partnerships. S. Rowe. SR Strategy. 512. NUTRITION AND PUBLIC HEALTH 513. PROMISE OF METABOLOMICS FOR POLICY: PROGRESS, OPPORTUNITIES ADVANCING NUTRITION RESEARCH AND CHALLENGES Symposium Symposium Wed. 8:00 am—San Diego Convention Center, Room Wed. 8:00 am—San Diego Convention Center, 31ABC Ballroom 20D Chaired: S. Subramaniam Chaired: A.L. Yaktine Cochaired: P. Maruvada Global and Community Nutrition 8:00 Food and Nutrition Board Update. C. Garza. Boston Col. Cellular and Molecular Nutrition 8:15 FNB’s Roundtable on Obesity Solutions and Innovation 8:00 Dynamic Diet-Induced Changes in Plasma Metabolomic Collaboratives. W. Purcell. Jones Hawkins and Lipidomic Profiles and the Potential for Estimating Farmer, PLC. Macronutrient Intake. C. Burant. Univ. of Michigan. 8:30 Panel: Cross-sector Solutions to Obesity in 8:20 Expanding Metabolomics to Exposome Analysis and Communities, Health Care and Evalutation. W. Dietz. Comprehensive Food Assessments. T. Cajka. Univ. George Washington Univ. of California, Davis. 8:40 The Metabotype of the Bloodtype, and Implications in Health and Nutritional Research. S. Sumner. RTI Intl. 9:00 Integrated Omics: Insights into Human Pathologies. S. Subramaniam. UCSD. Pathology

514. WORKSHOP: LONG NON-CODING RNA 515. BIOMARKERS AND TARGETED THERAPY

Workshop Minisymposium

Wed. 8:30 am—San Diego Convention Center, Room 2 Wed. 8:30 am—San Diego Convention Center, Room 3

Chaired: A. Dutta Chaired: G. Vecchio

Cochaired: P. Iannaccone Cochaired: D. Bell

Gene Expression Cancer Biology 8:30 Enhancers Arising: eRNAs and lncRNAs. M. Rosenfeld. Neoplasia Howard Hughes Med. Inst. 8:30 Introductory Remarks. 9:15 Long Noncoding RNAs in Human Diseases. H. Chang. 8:35 515.1 Influence of PI3K and MAPK Pathway Howard Hughes Med. Inst. Mutations on Response to Mono and Dual Treatment with 10:00 Long Noncoding RNAs in Regulation of Cell Proliferation Targeted Kinase Inhibitors. R.S. McNeill, D.A. Canoutas, R.E. and Differentiation. A. Dutta. Univ. of Virginia Hlth. Bash, R.S. Schmid, B.H. Constance, G.L. Johnson, C.R. Sci. Ctr. Miller. Univ. of North Carolina at Chapel Hill. 10:45 Clinical and Mechanistic Exploration of Long Noncoding RNA in Prostate Cancer. R. Malik. Univ. of Michigan Sch. of Med.

154 WEDNESDAY PATHOLOGY

8:50 515.2 EXPEL: A Novel Non-destructive Method for 9:30 516.5 Lack of β-Catenin in Hepatocytes Impairs Mining Soluble Tumor Biomarkers. A. Turtoi, B. Costanza, O. Proliferation and Leads to Increased Morbidity in Response Peulen, A. Bellahcène, E. De Pauw, O. Detry, P. Delvenne, V. to a Choline-Deficient Ethionine-Supplemented Diet. J.O. Castronovo. Univ. of Liege and Univ. Hosp. Liege, Belgium. Russell, H. Okabe, S. Singh, M. Poddar, S.P. Monga. Univ. 9:05 515.3 Optimization of a Series of Novel Chalcone of Pittsburgh. Derivatives for Anti-cancer Activity. T.L. Whited, C.R.T. Stang, 9:45 516.6 Hippo/YAP Signaling Induced by Endotoxin B.R. Adams, R.S. Khupse, R.W. Dudley, R.A. Schneider. Promotes Kupffer Cell Activation and Hepatic Inflammation in Univ. of Findlay, Col. of Pharm. Non-alcoholic Fatty Liver Disease. K. Song, H. Kwon, C. Han, 9:20 515.4 Single-Cell Biomarker Detection Identifies J. Zhang, L. Yao, N. Ungerleider, T. Wu. Tulane Univ. Sch. Heterogeneity within Cancer Populations. D. Weldon, Y. of Med. Williams, A. Patel. EMD Millipore, CA. 10:00 516.7 Maternal Obesity Programs Offspring’s 9:35 515.5 Targeting CSE1L in Colorectal Cancer. J. Predisposition to Non-alcoholic Fatty Liver Disease and Pimiento, K.G. Neill, E. Henderson-Jackson, S. Eschrich, Steatohepatitis. U.D. Wankhade, S.V. Chintapalli, Y. Zhong, P. D-T. Chen, K. Husain, D. Shibata, D. Coppola, M. Malafa. Kang, K. Shankar. Univ. of Arkansas Med. Sci. Moffitt Cancer Ctr., Tampa. 10:15 516.8 Role of TLR7 in Development of Alcoholic 9:50 515.6 Whole Transcriptome Analysis of Fatty Liver Disease: A New Target for Prevention of Alcoholic Osteosarcoma. S. Koks, E. Reimann, K. Maasalu, G. Koks, Fatty Liver Disease. H. Matsumoto, C. Yang, K. Sugimoto. D.H. Xuan, E. Prans, A. Martson. Univ. of Tartu, Estonia. Osaka Univ. Grad. Sch. of Med. 10:05 515.7 Downregulation of Alpha-L-Fucosidase 10:30 516.9 Biomarkers of Neutrophil-Mediated Liver Injury Expression Is Related to Dedifferentiation and Worse Prognosis in Patients with Alcoholic Liver Disease. B. Woolbright, W. in Thyroid and Breast Cancer. G. Vecchio, A. Parascandolo, Dunn, E. Malle, H. Jaeschke. Kansas Univ. Med. Ctr. and C. Allocca, C. Ugolini, F. Basolo, S. Bonin, G. Stanta, M.D. Med. Univ. of Graz, Austria. Castellone, M. Santoro, N. Tsuchida. Univ. of Naples Federico 10:45 516.10 Role of Sumoylation in Aldehyde II, ISO, Genova, Azienda Univ. Hosp. Pisana, State Univ. of Dehydrogenase 2 Function during Alcoholic Liver Disease. C. Trieste, IEOS, CNR, Naples and Tokyo Med. Dent. Univ. Cossu, K. Ramani, Y. Spissu, A. Floris, M.L. Tomasi. Cedars- 10:20 515.8 Identification of Lipocalin 2 in Human Sinai Med. Ctr., Univ. of Sassari and Univ. of Cagliari, Italy. Hepatoblastoma. D.E. Bell, J. Tao, S. Singh, M. Chikina, S. 11:00 516.11 Withdrawn. Ranganathan, S.P. Monga. Children’s Hosp. of Pittsburgh and 11:15 516.12 Regulation of Mesenchymal Phenotypes by W Univ. of Pittsburgh. MicroRNA-21 during Alcohol-Induced Liver Injury. F. Meng, E 10:35 515.9 Exploring Molecular and Morphological H. Francis, K. McDaniel, G. Alpini. Baylor Scott & White D Relationships between Obesity and CtBP in Breast Cancer. Healthcare, Texas A&M Hlth. Sci. Ctr. Col. of Med. and Central S.S. Park, D.I. Yi, D. Li, L. Crawford, G. Liang, M. Kabbout, R. Texas Veteran Healthcare Syst., Temple. Hernandez, T. Yan, S. Ambs, J.S. Byun, K. Gardner. NCI and NIMHD, NIH. 517. PATHOBIOLOGY OF INFECTIOUS DISEASES

516. COPING WITH HEPATIC INJURY Minisymposium

Wed. 8:30 am—San Diego Convention Center, Room 5A Minisymposium Inflammation/Immunity Wed. 8:30 am—San Diego Convention Center, Room 4 Immunopathology Chaired: S.P. Monga - Excellence in Cardiovascular Research 8:30 517.1 Giardia muris Protection against Citrobacter rodentium Colitis Is Associated with Inflammasome Activation Cochaired: M.L. Tomasi and Increased Release of Antimicrobial Peptides in the Gut. A. Liver Pathobiology Manko, J-P. Motta, J.A. Cotton, A. Oyeyemi, B.A. Vallance, J.L. Wallace, A.G. Buret. Univ. of Calgary and Univ. of British Cell and Tissue Injury Columbia, Canada. 8:30 516.1 The Ghrelin/Leptin Imbalance during 8:45 517.2 Cathelicidin Enhances the LPS-Inducing Cholestasis Is Driven by Peripheral S1P2R-Dependent Bile Synthesis of Toll-Like Receptors 4 in the Colonic Epithelium. Acid Signaling. S. DeMorrow, J. Zigman, M. McMillin. Texas M. Marin, R. Holani, C. Shah, Q. Haji, A. Odeón, E. Cobo. A&M Hlth. Sci. Ctr., Central Texas Veterans Healthcare Syst., CONICET, Buenos Aires and INTA, Balcarce, Argentina and Temple and Univ. of Texas Southwestern Med. Ctr. Cumming Med. Sch., Univ. of Calgary, Canada. 8:45 516.2 Regulation of p65-β-Catenin Complex and Its 9:00 517.3 Androstenetriol Enhances Lung Macrophage Targets in Liver Injury and Regeneration. K. Nejak-Bowen, Host Defense against Bacterial Pneumonia in Mice. L. Kobzik, P.K. Cornuet, S.P. Monga. Univ. of Pittsburgh. Z. Yang, P. Lu, F. Mo, R. Loria. Harvard Univ., Brigham and 9:00 516.3 Thrombospondin-1 Promotes Hepatic Injury and Women’s Hosp. and Virginia Commonwealth Univ. Extrahepatic Complications during Acute Liver Failure in Mice. M. 9:15 517.4 Synonymous Codon Changes in Measles McMillin, S. Andry, G. Frampton, S. Grant, G. Alpini, S. DeMorrow. (HMV) and Canine Distemper (CDV) Viral Nucleic Acid Texas A&M Univ. Hlth. Sci. Ctr., Central Texas Veterans Hlth. Care Sequences Result in Gene-Specific Changes in Levels of Viral Syst. and Baylor Scott & White Hlth., Temple, TX. Protein Expression. E.W. Uhl, M.L. Osborn, F.J. Michel, R.J. 9:15 516.4 Paradoxical Role of Yes-Associated Protein Hogan. Univ. of Georgia. in Liver Injury and Regeneration following Acetaminophen Overdose. S. Poudel, M.W. Manley, B. Bhushan, M.R. McGill, H. Jaeschke, U. Apte. Univ. of Kansas Med. Ctr.

155 PATHOLOGY/PHARMACOLOGY WEDNESDAY

518. NEUROPATHOLOGY: MODELS AND 10:30 518.3 Caveolin-1 Regulation of DISC1 as a Potential MECHANISMS OF DISEASE Therapeutic Target for Schizophrenia. A. Kassan, J. Egawa, Z. Zhang, Y. Lajevardi, K. Kim, Q.M. Nguyen, E.S. Posadas, Minisymposium A. Sawada, D.V. Jeste, D.M. Roth, P.M. Patel, H.H. Patel, B.P. Head. UCSD. Wed. 10:00 am—San Diego Convention Center, Room 5A 10:45 518.4 Role of Hippocampal Neurogenesis in Drug Chaired: C. Sigurdson Addiction. R.J. Morales Silva, M.H. Galinato, C. Mandyam. Univ. of Puerto Rico, Ponce and The Scripps Res. Inst. Cochaired: C. Kolarcik 11:00 518.5 Brainstem Pathology Induces Peripheral Changes Correlating with Hippocampal Markers of Alzheimer’s Neurobiology Disease in Animal Model. P. Filipcik, M. Cente, S. Zorad, M. Neuropathology Fecik, M. Novak. Inst. of Neuroimmunol., Axon Neurosci. SE and Inst. of Exptl.l Endocrinol., Bratislava, Slovakia. 10:00 518.1 Role of Post-translational Modifications In 11:15 518.6 Changes in Plasma and Urine Docosahexaenoic Prion Strain Diversity. P. Aguilar-Calvo, C. Bett, H. Eraña, Acid Levels in Alzheimer’s Disease. A.N. Fonteh, K. Castor, E. J. Castilla, P. Nilsson, C. Sigurdson. UCSD, CIC bioGUNE, Chung, S. Applegate, M. Harrington. Huntington Med. Res. Spain and Linköping Univ., Sweden. Insts., Pasadena. 10:15 518.2 The Biophysical Determinants of Prion 11:30 518.7 Effect of Stabilizing Alpha Synuclein- Neuroinvasion. C. Sigurdson, J. Lawrence, C. Bett, T. Kurt, Membrane Interactions on the Protein’s Aggregation and C. Wu, W. Surewicz, K.P.R. Nilsson. UCSD, Case Western Neurotoxicity. D. Ysselstein, V. Mishra, G. McCabe, J-C. Reserve Univ. and Linköping Univ., Sweden. Rochet. Purdue Univ. Pharmacology

519. RAY FULLER LECTURE IN THE 11:20 Sex Differences in the Brain are Established Early and NEUROSCIENCES: SEX BIASED Enduringly. M. McCarthy. Univ. of Maryland Sch. of Med. STRESS SIGNALING 11:55 Wrap up.

Lecture 521. KEEP CALM AND TARGET PEPTIDES: MODULATION OF STRESS-RELATED Wed. 8:30 am—San Diego Convention Center, Room 16A BEHAVIORS BY NEUROPEPTIDE SYSTEMS Neuropharmacology Symposium Neurobiology (Sponsored by: The Division for Behavioral Pharmacology) The Ray Fuller Lecture in the Neurosciences was established to honor the achievements of Ray W. Fuller, PhD in applying an (Cosponsored by: The Divisions for Neuropharmacology, improved understanding of the central nervous system to discover Molecular Pharmacology, and Drug Discovery better treatments for the mentally ill. Dr. Fuller was one of the and Development) triad that discovered fluoxetine (Prozac), leading to an entire new Wed. 9:30 am—San Diego Convention Center, Room 17A approach to the therapy of depression. Cochaired: S. Clark and V. Sabino 8:30 Introduction. 8:35 Sex Biased Stress Signaling. R.J. Valentino. Children’s Behavioral Pharmacology Hosp. of Philadelphia, Univ. of Pennsylvania. Neurobiology 520. RAY FULLER SYMPOSIUM: SEX DIFFERENCES 9:30 Opening Remarks. IN BIOLOGY: CHALLENGES AND 9:35 Genetic Dissection of the CRF-System in the Extended OPPORTUNITIES FOR DRUG DEVELOPMENT Amygdala. A. Chen. Max Plank Inst. of Psychiat. 10:00 Role of Extended Amygdala PACAP in the Behavioral Symposium Response to Acute and Chronic Stress. V. Sabino. Boston Univ. Sch. of Med. Wed. 9:30 am—San Diego Convention Center, Room 16A 10:25 Neuropeptide Y in the Basolateral Amygdala: Role in Chaired: R.J. Valentino Stress Resilience. J. Urban. Franklin Univ. of Med. and Sci. 9:30 Introduction. R.J. Valentino. Children’s Hosp. of 10:50 Amygdaloid Corticotropin Releasing Factor as the Philadelphia, Univ. of Pennsylvania. Key Mediator of Chronic Visceral Pain in Females 9:35 Estrogens Enhance Female Vulnerability to Drug with a History of Early Life Stress. D.K. Prusator, B. Addiction. P. Mermelstein. Univ. of Minnesota. Greenwood-Van Meerveld. Univ. of Oklahoma Hlth. 10:10 Social Defeat Stress in Males and Female: Role Sci. Ctr. (720.7) of Kappa Opioid Receptors. B. Trainor. Univ. of 11:05 ProSAAS-Derived Peptides: Major Brain Neuropeptides California, Davis. Implicated in the Regulation of Stress and Reward- 10:45 Sex Differences in Ketamine’s Antidepressant-Like Related Behaviors. L. Devi. Mount Sinai Univ. Effects. M. Kabbaj. Florida State Univ.

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11:30 Development of Neuropeptide S Receptor Targeted 10:05 Mineralocorticoid Receptor Signaling and Cardiovascular Compounds as Potential Therapies for Anxiety- Stiffness in Insulin Resistance. J.D. Sowers. Univ. of Related Disorders. S. Clark. Univ. at Buffalo, SUNY. Missouri Sch. of Med. 11:55 Closing Remarks. 10:30 Self-Renewal of Cardiomyocyte: Metabolic Signals as Regulators of Protein Turnover. H. Taegtmeyer. The 522. CANCER STEM CELLS AS Univ. of Texas Health Sciences Ctr. PHARMACOLOGICAL TARGETS 10:55 Therapeutic Targeting of Autophagy in the Management of Cardiometabolic Diseases. Y. Zhang. Xijing Hosp., Symposium Fourth Military Med. Univ. 11:20 Metabolic Syndrome Perivascular Adipose Tissue (Sponsored by: The Division for Cancer Pharmacology) Impairment of Aortic Reactivity Post Stroke, Improved (Cosponsored by: The Divisions for Molecular by NOX2 Inhibition. E. DeVallance, K. Branyan, K. Pharmacology, Translational and Clinical Pharmacology, Lemaster, R. Skinner, S. Brooks, J. Frisbee, P. and Drug Discovery and Development ) Chantler. West Virginia Univ. (1269.5) 11:35 Mitochondrial Function of Cerebral Vasculature in Insulin Wed. 9:30 am—San Diego Convention Center, Room 17B Resistant Zucker Obese Rats. I. Merdzo, I. Rutkai, T. Tokes, V.N.L.R. Sure, P.V.G. Katakam, D.W. Busija. Cochaired: J.S. Gutkind and T. Reya Tulane Univ. Sch. of Med. (717.6) Cancer Pharmacology 11:50 Summary. Cancer Biology 524. INTRACELLULAR GPCR AND LIPID SIGNALING Regenerative Medicine (Stem Cells, Tissue Regeneration, Biomaterials) Symposium 9:30 Targeting the Cancer Cell Cycle: The Development of (Sponsored by: The Division for Molecular Pharmacology) Palbociclib in Breast Cancer. R. Abraham. Pfizer Inc. (Cosponsored by: The Divisions for Cardiovascular 10:00 Drug Treatment or Cellular Stress Drives Tumor Pharmacology, Neuropharmacology, and Translational Reprogramming, Progression and Drug Resistance. W and Clinical Pharmacology ) D. Cheresh. UCSD. E 10:30 Heterotrimeric G-Protein α​ Subunit Chaperone Ric-8A Wed. 9:30 am—San Diego Convention Center, Room 15B D as a Novel Target for Cancer Therapeutics. B. Patel. Univ. of Rochester Med. Ctr. Cochaired: A. Marchese and A. Smrcka 10:45 mTOR Co-targeting Strategies Against Oral Molecular Pharmacology Malignancies andTheir Cancer Initiating Cells. Z. Wang. UCSD Neurobiology 11:00 Lung Stem Cell Approaches to Understanding 9:30 GPCR Promoted Akt Signaling from Early Endosomes. Differentiation, Disease and Therapy. C. Kim. Harvard A. Marchese. Loyola Univ. Chicago. Stem Cell Inst. 10:05 Ubiquitin Regulates GPCR-Induced p38 MAPK 11:30 Stem Cell Properties Using Patient-Derived Circulating Signaling from Endosomes. J. Trejo. UCSD. Tumor Cells. M. Yu. Univ. of So. California 10:35 Lipid Signaling from the Golgi. A. Smrcka. Univ. of Rochester Med. Ctr. 523. NOVEL TARGETS FOR TREATMENT OF 11:05 Phosphatidylinositol 4-Phosphate: A Lipid’s Journey to CARDIOMETABOLIC DISEASES Fame. T. Balla. NICHD, NIH. 11:35 Structural and Functional Characterization of the Symposium Metastatic RhoGEF P-Rex1 and Its Regulation by PtdIns(3,4,5)P : Towards Inhibitory Small Molecule (Sponsored by: The Division for 3 Development. J.N. Cash, E.M. Davis, J.J.G. Tesmer. Cardiovascular Pharmacology) Univ. of Michigan. (1190.5) (Cosponsored by: The Divisions for Molecular 11:48 Spatial Encoding of Cyclic AMP Signaling Specificity by Pharmacology, Translational and Clinical Pharmacology, GPCR Endocytosis. N. Tsvetanova, M. von Zastrow. and Drug Discovery and Development ) UCSF. (1266.1)

Wed. 9:30 am—San Diego Convention Center, Room 15A

Cochaired: J. Ren and S. Nair

Cardiovascular Pharmacology Metabolism and Metabolic Disease 9:30 Introduction. J. Ren. Univ. of Wyoming. 9:40 Interplay of Oxidative Stress, Inflammation, and Cell Death, in Diabetic Cardiomyopathy. P. Pacher. NIAAA, NIH.

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525. DRUG TRANSPORTER PROTEIN 3:33 Organic Cation Transporter 3: An Unsuspected Player QUANTIFICATION BY LC-MS/MS FOR IN VITRO in the Actions of Amphetamine and a New Target for TO IN VIVO EXTRAPOLATION AND PREDICTION Psychotherapeutic Drug Development. L.C. Daws. OF INTERINDIVIDUAL VARIABILITY OF Univ. of Texas Hlth. Sci. Ctr. at San Antonio. 4:01 Transporters as Clinical Targets of Drugs: TRANSPORTER MEDIATED DRUG DISPOSITION Amphetamines, New Psychoactive Substances and the Monoamine Transporter Cycle. H.H. Sitte. Med. Symposium Univ. Vienne, France. (Sponsored by: The Division for Translational and 4:29 DAT and EAAT3 Trafficking Regulation by Amphetamine: Clinical Pharmacology) Integration of Dopaminergic and Glutamatergic Signaling. S.M. Underhill. NIMH, NIH. (Cosponsored by: The Divisions for Cardiovascular 4:57 Sick, Stressed, Depressed, and Addicted: Immune Pharmacology and Drug Metabolism ) Modulation of Cocaine Targets. N.L. Baganz. Wed. 9:30 am—San Diego Convention Center, Room 16B Vanderbilt Univ. 5:25 Closing Remarks. Cochaired: B. Prasad and Y. Lai

Translational and Clinical Pharmacology 527. MODULATION OF BSEP AND MDR3 IN DRUG- INDUCED LIVER INJURY Transporters/Channels/Barriers 9:30 Blood-Brain Barrier Pharmacoproteomics: Symposium Reconstruction of In Vivo Brain Drug Distribution in (Sponsored by: The Division for Toxicology) Mouse, Monkey and Diseased Models. T. Terasaki. Tohoku Univ. (Cosponsored by: The Divisions for Drug Metabolism, 10:03 Quantitative Proteomics for IVIVE of Transporter Drug Discovery and Development, and Molecular Mediated Drug Clearance. Y. Lai. Bristol- Pharmacology ) Myers Squibb. Wed. 3:00 pm—San Diego Convention Center, Room 17A 10:36 No Escape from Models in Translating LCMS-Derived Abundance Values!. A. Rostami. Univ. of Manchester. Cochaired: K. He and D. Rodrigues 11:09 Effect of Ontogeny and Pharmacogenomics on Transporter Mediated Interindividual Variability in Toxicology Drug Disposition. B. Prasad. Univ. of Washington. 3:00 Introduction. D. Rodrigues. Pfizer Co. 11:42 Chronic Paroxetine Treatment in Mice Leads to Adiposity 3:05 Integration of BSEP Inhibition Data in DILIsym®: and Glucose Intolerance. W. Zha, J. Wang. Univ. of Perspectives from System. P. Watkins. The Hamner Washington. (717.4) Insts. for Hlh. Scis. 3:35 BSEP Inhibition in Drug Discovery Screening. R. 526. NEW TWISTS ON NEUROTRANSMITTER Morgan. Amgen, Inc. TRANSPORT: UNRAVELING NOVEL 4:05 Novel BSEP and MDR3 Assays Using Primary THERAPEUTIC TARGETS FOR ADDICTION AND Hepatocytes for Screening DILI Drugs and Species PSYCHIATRIC DISORDERS Differences. K. He. Biotranex LLC. 4:35 The Role of Bile Salt Export Pump Gene Repression Symposium in Drug-Induced Cholestatic Liver Toxicity. B. Garzel. Univ. of Maryland Sch. of Pharmacy. (Sponsored by: The Division for Neuropharmacology) 5:00 BSEP and MDR3 Inhibition by DILI Drugs and the (Cosponsored by: The Divisions for Molecular Implications with Systems Biology Analysis. J. Zhang. Pharmacology and Behavioral Pharmacology ) Natl. Ctr. for Toxicol. Res.

Wed. 3:00 pm—San Diego Convention Center, Room 16A

Cochaired: L.C. Daws and H.H. Sitte

Neuropharmacology Neurobiology Transporters/Channels/Barriers Join Us Next Year! 3:00 Introduction. 3:05 Integrating Organic Cation Transporter 3 into Models Experimental Biology 2017 of Dopamine Clearance and Cocaine Addiction. P.J. Gasser. Marquette Univ. April 22–26 Chicago, IL www.experimentalbiology.org

158 WEDNESDAY PHARMACOLOGY/PHYSIOLOGY

528. THE BIOLOGY AND TRANSLATIONAL 529. TRANSLATING MICRORNA CANCER BIOLOGY POTENTIAL OF HYDROGEN SULFIDE: TO THERAPY ONE PERSON’S TRASH IS ANOTHER PERSON’S TREASURE Symposium (Sponsored by: The Division for Cancer Pharmacology) Symposium (Cosponsored by: The Divisions for Drug Discovery (Sponsored by: The Division for Drug Discovery and Development and Translational and Clinical and Development) Pharmacology )

(Cosponsored by: The Divisions for Molecular Wed. 3:00 pm—San Diego Convention Center, Room 17B Pharmacology, Cancer Pharmacology, and Translational and Clinical Pharmacology ) Cochaired: A. Yu and A.G. Bader

Wed. 3:00 pm—San Diego Convention Center, Room 16B Cancer Pharmacology

Cochaired: J.L. Wallace and A. Papapetropoulos Cancer Biology

Drug Discovery and Development 3:00 MicroRNA Replacement Therapy. A.G. Bader. Mirna Therapeutics, Inc. Cancer Biology 3:35 Modulating MicroRNAs to Improve Cancer Therapy. 3:00 H2S Actions and Interactions with NO in the Cardiovascular J.J. Welsh. Univ. of Texas MD Anderson Cancer Ctr. System. A. Papapetropoulos. Univ. of Athens. 4:10 A Combinatorial MicroRNA Therapeutics Approach to 3:25 Diet, H2S and Longevity. J.R. Mitchell. Harvard Sch. of Suppressing Cancer Growth. A. Kasinski. Purdue Univ. Publ. Hlth. 4:45 Recombinant MicroRNAs as Novel Cancer Therapeutics. 3:50 Modulation of H2S as an Anti-cancer Strategy. C. A. Yu. Univ. of California Davis Sch. of Med. Szabo. The Univ. of Texas Med. Branch at Galveston. 5:15 miR-186 Suppresses Cell Proliferation and Anchorage- 4:15 H2S and Glucose Metabolism. L. Wu. Lakehead Univ. Independence in a Metastatic Prostate Cancer Cell Line. D.Z. Jones, M.L. Schmidt, K.R. Hobbing, 4:40 Development of H2S-Releasing, GI-Safe Anti- W inflammatory Drugs. J.L. Wallace. Univ. of G. Clark, L.R. Kidd. Univ. of Louisville. (936.6) Calgary, Canada. E 5:05 Transdermal Detection of Low Concentrations of 530. CLOSING RECEPTION D Hydrogen Sulfide. L. Rios, D. Friedrichsen, C. Mowry, G. Silaski, R. Shekarriz, N.L. Kanagy. Univ. Special Event of New Mexico, Exhalix and Sandia Natl. Labs., Wed. 6:00 pm—San Diego Marriott Marquis & Marina Albuquerque. (1271.3) Hotel, South Tower Poolside 5:18 Sodium Hydrosulfide Alleviates Cecal Ligation and Puncture-Induced Sepsis and Elevates the Regional We invite ASPET members and pharmacology attendees to Blood Flow in Septic Shock. A. Ahmad, C. Szabo. join us for a closing reception. Univ. of Texas Med. Branch and Shriners Hosp. for Children. (1271.7)

Physiology

531. APS PRESIDENT’S SYMPOSIUM SERIES 532. BREATHING DISTURBANCES IN PHYSIOLOGICAL MECHANISMS NEUROLOGICAL DISORDERS RESPONSIVE TO BEHAVIORAL AND ENVIRONMENTAL CHALLENGES Featured Topic (Sponsored by: APS Central Nervous System Section) NOBEL PRIZE AWARD LECTURE Wed. 8:00 am—San Diego Convention Center, Room 25C

Lecture Chaired: T. Moreira

Wed. 4:45 pm—San Diego Convention Center, Neurobiology Ballroom 20A Neurophysiology Cancer Biology 8:00 Breathing Challenges in Rett Syndrome: Lessons Molecules against Cancer or for Very Long-Term Learned from Humans and Animal Models. Memory. R. Tsien. HHMI, UCSD. J. Ramirez. Seattle Children’s Res. Inst. 8:30 Breathing Disturbances in Neurodegenerative Disorders. M. Dutschmann. Florey Inst., Parkville, Australia.

159 PHYSIOLOGY WEDNESDAY

9:00 Failure in Central Respiratory 5HT-Dependent 8:45 Evidence of Disrupted Human Heat Balance in Heart Chemoreception in a Genetic Model of Epilepsy. Failure Patients Exercising in the Heat. B. Balmain, L.T. Totola, A.C. Takakura, J.A. de Oliveira, N. O. Jay, S. Sabapathy, D. Royston, G. Stewart, R. Garcia-Cairasco, T.S. Moreira. Univ. of São Paulo, Jayasinghe, Y. Eqbal, N. Morris. Griffith Univ., Univ. São Paulo and Ribeirão Preto. (1285.1) of Sydney and Gold Coast Univ. Hosp., Australia. 9:15 Genome-Wide Assessment of the Pompe (Gaa-/-) (1290.4) Mouse Cervical Spinal Cord Confirms Widespread 9:00 Whole-Body Heat Loss Is Enhanced in Older Adults Neuropathology. S. Turner, A. Hoyt, D. Falk, B. following a Summer in a Humid Continental Climate. Byrne, D. Fuller. Univ. of Florida. (1285.2) M.P. Poirier, S. Dervis, A.D. Flouris, G.P. Kenny. 9:30 Characterization of Respiratory Activity in Spontaneously Univ. of Ottawa, Canada and Univ. of Thessaly, Breathing Urethane-Anesthetized 6-OHDA SN- Greece. (1290.13) Lesioned Parkinson’s Disease Rat Model. I.C. 9:15 Brown Adipose Tissue Characteristics of Epicardial Fat Solomon, W.F. Collins. Stony Brook Univ. (1285.3) and Its Relationship with Growth during Aging in Early 9:45 Cervical Spinal Contusion Alters NKCC1 and KCC2 Life. H. Budge, S. Ojha, P.H. Fainberg, V. Wilson, Expression in Phrenic Motor Neurons. L.L. Allen, Y.B. M. Castellanos, G. Pelella, A. Lotto, H. Sacks, M. Seven, T. Baker, G.S. Mitchell. Univ. of Florida and Symonds. Univ. of Nottingham, Nottingham and Univ. of Wisconsin-Madison. (1285.4) Loughborough, Glenfield Hosp., Leicester, U.K. and UCLA. (1290.12) 533. CARDIAC MITOCHONDRIA: MORE THAN AN 9:30 Aging Modifies Reflex Cardiovascular Responses ATP POWER PLANT to Local and Systemic Cold Exposure. M. Muller. Pennsylvania State Univ. Coll. of Medicine. Symposium 535. MECHANISMS UNDERLYING HOST-MICROBIAL (Sponsored by: Pan-American Societies) INTERACTIONS IN PATHOPHYSIOLOGY Wed. 8:00 am—San Diego Convention Center, Room 23 OF DISEASES

Chaired: V.R. Antunes and M.C. Villa-Abrille Symposium 8:00 Mitochondria: Getting to the Heart of the Matter. (Sponsored by: APS Gastrointestinal and Liver R. Gottlieb. Cedars-Sinai Heart Inst. Physiology Section) 8:30 Targeting Mitochondrial Aldehyde Dehydrogenase 2 in Cardiac Diseases. J. Baptista Ferreira. Univ. of Wed. 8:00 am—San Diego Convention Center, Room 25A São Paulo. Chaired: P.K. Dudeja and J. Sun 9:00 Mitochondrial Energetic-Redox Regulation of Heart Disease: An Experimental-Computational Modeling Neurophysiology Approach. M. Aon. NIH, NIA. 9:30 Mitochondria and Cardiac Hypertrophy: Pros and Cons. Diet, Nutrition and Metabolism, and Development I. Ennis. Natl. Univ. de la Plata, Buenos Aires. Microbiome 8:00 The Microbiome Co-Opts Genetic Pathways Linked to 534. HOT, COLD, AND OLD: AGING AND THE Inflammatory Bowel Disease. H. Chu. Caltech. PHYSIOLOGY OF THERMAL STRESS 8:30 The Impact of Diet-induced Gut Microbiota on Circadian Rhythm and Obesity. V. Leone. Univ. of Chicago. Featured Topic 9:00 Bacterial-Infected Organoid Culture System for Host– (Sponsored by: APS Environmental and Exercise Bacterial interactions. V. Young. Univ. of Michigan. Physiology Section) 9:30 Immunologic Tolerance to Intestinal Microbiota Depends on Rab11 Endosome Mediated Control of Wed. 8:00 am—San Diego Convention Center, Room 28A Pathogen Pattern Recognition Receptor Processing Chaired: Z. Schlader and D. Gagnon and Signaling. N. Gao. Rutgers Univ.

Exercise, Aging, and Disease 536. MICROTUBULES IN LUNG DISEASE Environmental Stress AND RECOVERY

8:00 Understanding the Effects of Aging on the Body’s Symposium Physiological Capacity to Dissipate Heat. G. Kenny. Univ. of Ottawa. (Sponsored by: APS Respiration Section) 8:30 Blunted Increases in Skin Sympathetic Nerve Activity Wed. 8:00 am—San Diego Convention Center, Room 25B Contribute to the Attenuated Reflex Vasodilation in Aged Human Skin. A.E. Stanhewicz, J.L. Greaney, Chaired: A. Birukova and T. Stevens L.M. Alexander, W.L. Kenney. Penn State. (1290.1) Transporters/Channels/Barriers 8:00 Microutubule Dynamics Modulates Endothelial inflammation induced by High Pulsatility Flow. K. Stenmark. Univ. of Colorado, Denver.

160 WEDNESDAY PHYSIOLOGY

8:25 MT-Associated Trafficking of VEGFR2 Is Necessary for 9:25 Translating Hydrogen Sulfide Therapeutics to the Clinic. Lung Recovery. Y. Komarova. Univ. of Illinois Col. D. Lefer. LSU Hlth. Sci. Ctr., New Orleans. of Med. 8:50 Role of Microtubules in Chronic EC Barrier Dysfunction 539. RENAL POTASSIUM SENSING MECHANISMS: A in P. aeruginosa-Infected Pulmonary Endothelium. NEW PARADIGM FOR POTASSIUM SECRETION T. Stevens. Univ. of South Alabama. 9:15 Microtubule-Dependent Mechanisms of Lung Vascular Symposium Barrier Restoration. Y. Ke. Univ. of Chicago. 9:40 Reduced Microtubule Acetylation in Cystic Fibrosis (Sponsored by: APS Renal Section) Epithelial Cells. S. Rymut. Case Western Wed. 8:00 am—San Diego Convention Center, Room 27 Reserve Univ. Chaired: D. Ellison and A. Subramanya

537. NEW APPROACHES FOR INDUCTION Transporters/Channels/Barriers OF ARTERIOGENESIS 8:00 Renal Potassium Sensing. A. Terker. Oregon Hlth. & Featured Topic Sci. Univ. 8:30 Regulation of Kir.4.1 in the Kidney. W-H. Wang. New (Sponsored by: APS Cardiovascular Section) York Med. Col. Wed. 8:00 am—San Diego Convention Center, Room 22 9:00 FHHt Proteins form an Endocytic Switch for the the ROMK Channel. P. Welling. Univ. of Maryland Baltinore. Chaired: P. Rocic 9:30 Regulation of WNK/SPAKI by Dietary K Intake. C-L.Huang. Univ. of Texas Southwestern Med. Ctr. 8:00 Use of Ephrin-B2-Activated Peripheral Blood Mononuclear Cells for Cellular Therapy in Patients with Critical Limb Ischemia. B. Levy. INSERM, Paris. 540. REPROGRAMMED CELLS AS MODELS 8:45 Passive Heat Therapy as a Novel Approach for Inducing FOR DISEASE Angiogenesis in Humans: Roles of Nitric Oxide. V.E. Brunt, K.W. Needham, L.N. Comrada, M.A. Symposium W Francisco, C.T. Minson. Univ. of Oregon. (1211.1) Wed. 8:00 am—San Diego Convention Center, Room 24 E 9:00 DPPI Deficiency Enhances Both Angiogenesis and D Arteriogenesis and Improves Cardiac Function Chaired: W.M. Chilian and E. Pashos after Myocardial Infarction. M.A. Kolpakov, B. Hooshdaran, X. Guo, T. Wang, K. Rafiq, L. Vlasenko, Microbiome Z. Qi, V.N.S. Garikipati, R. Kishore, S.R. Houser, Regenerative Medicine (Stem Cells, Tissue A. Sabri. Temple Univ. and Thomas Jefferson Univ. Regeneration, Biomaterials) (1211.2) 8:00 Creation of Reprogrammed Cells to Study Vascular 9:15 Angiotensin-(1-7) Requires both Mas1 and AT1 Receptors to Restore Angiogenesis. T. Stodola, E. Growth. L. Yin. Northesast Ohio Med. Univ. Exner, B. Hoffmann, D. Didier, A. Greene. Med. Col. 8:25 Modeling Biliary Disease Using Stem Cell-Derived of Wisconsin. (1211.3) Cholangiocytes. R. Huebert. Mayo Clin. 9:30 Matricryptin p1158/59 Modulates Vascular Remodeling 8:50 Interrogating Cardiometabolic Association Signals during Carotid Artery Bypass. P.R. Shaver, G.A. Grilo, in Human iSPC-Hepatocytes. E. Pashos. Univ. of K.C. Barefoot, A.W. Holt, D.A. Tulis, R.M. Lust, L.E. Pennsylvania Perelman Sch. of Med. de Castro Brás. East Carolina Univ. (1211.4) 9:15 The Use of iPS Cells to Study Type 1 Diabetes. I. Yasuhiro. Mayo Clin. 9:40 Panel Discussion with Questions from the Audience. 538. NOVEL MOLECULAR TARGETS AND THERAPEUTIC APPROACHES IN MYOCARDIAL 541. ROLE OF OXYTOCIN IN THE CONTROL OF INFARCTION AND HEART FAILURE ENERGY HOMEOSTASIS Symposium Symposium (Sponsored by: APS Translational Physiology (Sponsored by: APS Endocrinology and Interest Group) Metabolism Section) Wed. 8:00 am—San Diego Convention Center, Room 26 Wed. 8:00 am—San Diego Convention Center, Room 28B Chaired: W.J. Koch and T.E. Sharp Chaired: J. Blevins and W. Samson 8:00 RhoA Signaling Pathways in Heart Failure. Diabetes, Metabolic Syndrome M. Kontaridis. Beth Israel Deaconess. 8:20 Harnessing Cardiac Progenitor Cells in Heart Disease. Metabolism and Metabolic Disease J. van Berlo. Univ. of Minnesota. 8:40 Targeting Mitochondrial Calcium Exchange Mechanisms 8:00 increased Oxytocin Signaling Attenuates Weight Gain in Heart Failure. J. Elrod. Temple Univ. Sch. of Med. in Diet-Induced Obese Rodents and Nonhuman 9:00 Autophagy in the Development of Heart Failure. Primates. J. Blevins. Univ. of Washington, VA Puget Å. Gustafsson. UCSD. Sound Hlth. Care Syst.

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8:30 Hindbrain Oxytocin Receptor Signaling: Effects on 543. COMPARATIVE PHYSIOLOGY OF SKELETAL Energy Balance Control. Z. Yi. Univ. of Pennsylvania. MUSCLE – NOVEL STUDIES IN PLASTICITY 9:00 Salt-Loading Reveals Brain Oxytocin Circuits that AND STRUCTURE Modulate Stress Responding. E. Krause. Univ. of Florida. Symposium 9:30 Effects of Oxytocin on Caloric Intake and Metabolism in Men. E. Lawson. Harvard Med. Sch. (Sponsored by: APS Comparative and Evolutionary Physiology Section)

542. ACTIONS AND INTERACTIONS OF Wed. 10:30 am—San Diego Convention Center, Room 25C BAROREFLEXES, CHEMOREFLEXES Chaired: B. Rourke and A. Horner AND METABOREFLEXES IN AUTONOMIC REGULATION AND HEART DISEASE Environmental Stress Skeletal Muscle Physiology Featured Topic 10:30 Structural Basis of Muscle Work Capacity. N. Holt. Univ. (Sponsored by: APS Neural Control and Autonomic of California, Irvine. Regulation Section) 11:00 The Function of Oblique Striation Explained? Tuning Wed. 10:30 am—San Diego Convention Center, Room 28B the Length-Force Relationship in the Muscles of Soft-Bodied Invertebrates. J. Thompson. Franklin & Chaired: M. Amann and P. Fadel Marshall Col. Neurobiology 11:30 Polar Bear Skeletal Muscle Primarily Reflects Recent Activity Rather than a Seasonal Pattern. J. Whiteman. Neurophysiology Univ. of Wyoming. Myocardial Infarction/Heart Failure 12:00 Why Are Sloths So Strong? Unique Muscle Modifications for Suspensorial Locomotion. M. Butcher. 10:30 Carotid Body Chemoreflex in Animals: Health and Heart Youngstown State Univ. Failure. N. Marcus. Univ. of Nebraska Med. Ctr. 11:00 Baroreflex-Metaboreflex Interaction in Animals: Health 544. COMPARTMENTALIZATION OF SIGNAL and Heart Failure. D. O’Leary. Wayne State Univ. TRANSDUCTION IN EPITHELIAL 11:30 Activation of the Chemo- and Cardiopulmonary Reflexes Blunt Baroreflex Sensitivity through Independent CELL BIOLOGY Mechanisms. H.G. Petersen-Jones, W.W. Holbein, B.D. Johnson, V.A. Convertino, T.B. Curry, M.J. Symposium Joyner. Mayo Clin., Univ. at Buffalo and U.S. Army (Sponsored by: APS Epithelial Transport Group) Inst. of Surg. Res., Houston. (1286.1) 11:45 Diastolic Dysfunction and Arrhythmia Incidence Are Wed. 10:30 am—San Diego Convention Center, Room 27 Exacerbated by Central Chemoreflex Activation Chaired: R.A. Fenton and T. Rieg in HfpEF. R. Del Rio, C. Toledo, D.C. Andrade, C. Lucero, V. Aliaga, N.J. Marcus, C. Madrid. Diabetes, Metabolic Syndrome Autonomous Univ. of Chile, Santiago and Des Moines Ion Transport Univ. (1286.2) 12:00 Increased Brain-Derived Neurotrophic Factor in Lumbar 10:30 Compartmentalization of Cellular Signaling Using Dorsal Root Ganglia Contributes to the Enhanced Fluorescent Biosensors. J. Zhang. Johns Skeletal Muscle Afferent Neuronal Excitability via Hopkins Univ. a MAPK-Dependent Pathway in Heart Failure. H. 11:00 Monitoring Spatiotemporal cAMP Production in Living Wang, G. Rozanski, I.H. Zucker. Univ. of Nebraska organisms. M. Lohse. Univ. of Wuerzburg. Med. Ctr. (1286.3) 11:30 PDEs in cAMP Signaling. W. Richter. Univ. of 12:15 Unilateral Carotid Body Resection in Patients with South Alabama. Resistant Hypertension: A Safety and Feasibility 12:00 Localization of β(2)-Adrenergic Receptor Mediated Trial. E.C. Hart, L.E.K. Ratcliffe, K. Narkiewicz, cAMP Signaling Using Scanning Ion Conductance L.J.B. Briant, M. Chrostowska, J. Wolf, Szyndler, Microscopy. J. Gorelik. Imperial Col. London. D. Hering, A.E. Burchell, A.P. Abdala, C. Durant, M. Lobo, P.A. Sobotka, N. Patel, J. Leiter, Z.J.B. Engelman, A.K. Nightingale, J.F.R. Paton. Univ. of Bristol, Gdansk Med. Univ., BARTS and London Sch. of Med., The Ohio State Univ., Dartmouth Geisel Sch. of Med. and Cibiem, Los Altos. (1286.4)

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545. EMERGING NEW MECHANISM IN ALCOHOLIC 547. NOW HIRING PHDS: POSTDOC NOT REQUIRED LIVER DISEASE Symposium Symposium (Sponsored by: APS Trainee Advisory Committee) (Sponsored by: American Federation for Wed. 10:30 am—San Diego Convention Center, Room 22 Medical Research) Chaired: A.M. Hernandez-Carretero and B. Dougherty Wed. 10:30 am—San Diego Convention Center, Room 23 Career Development Chaired: S. Liangpunsakul 10:30 A Goal without a Plan Is Just a Wish. P. Clifford. Univ. 10:30 Fat-Specific Protein 27/CIDEC Plays an Important of Illinois at Chicago. Role in Promoting Alcoholic Liver Injury in Mice and 10:45 After Your PhD: The Non-traditional Career Path for Humans. B. Gao. NIAAA, NIH. Scientists. M. Urso. Smith & Nephew Biotherapeutics, 11:00 Role of Hepatic Microphages in Alcohol Liver Disease. C. Hull, MA. Ju. Skaggs Sch. of Pharm. and Pharmaceut. Sci., UCSD. 11:00 How to Love What You Do and Be Good at It: Being 11:30 Circadian Clock Mediated Homocysteine Metabolism in Competitive in the 21St Century Job Market. S. Zarate. Alcoholic Fatty Liver. L. Wang. Univ. of Connecticut. Univ. of San Diego. 12:00 The Pivotal Role Played by Lipocalin-2 in Mediating 11:15 Medical and Science Writing: No Postdoc Required. Detrimental Effects of Ethanol in the Liver. M. You. A. Gwosdow. Gwosdow Assoc. Sci. Consultants, Northeast Ohio Med. Univ. Arlington, MA. 11:30 Successfully Attaining a Position in Academic 546. ENDOTHELIAL DYSFUNCTION IN DIABETES Technology Transfer without a Postdoc. J. Mitzelfelt. Univ. of Maryland College Park. Featured Topic 11:45 From Inside the Lab to Inside the Beltway: A Career in (Sponsored by: APS Cardiovascular Section) Science Policy. C. Wolinetz. OSP, NIH. 12:00 Transferable Skills between Academics and Industry: Wed. 10:30 am—San Diego Convention Center, Room 26 Making the Most of Your PhD. B. Kirby. Nike Sport W Res. Lab. Chaired: B. Dokken and C. Meininger E D Diabetes, Metabolic Syndrome 548. RECENT ADVANCES IN THE STRUCTURE AND Barriers: Endothelium and Epithelium FUNCTION OF EPITHELIAL TIGHT JUNCTIONS

10:30 Effects of Glucose on the Endothelial Extracellular Symposium Matrix. B. Dokken. Univ. of Arizona. 11:00 Hyperglycemia-Induced Glycosylation: A Driving (Sponsored by: APS Cell and Molecular Force for Vascular Dysfunction in Diabetes? Physiology Section) B.R. Hoffmann, M.E. Widlansky, A.S. Greene. Med. Wed. 10:30 am—San Diego Convention Center, Room 25A Col. of Wisconsin. (1282.13) 11:15 Dynamic Regulation of Endothelial Cell-Specific Chaired: R.K. Rao and S. Vetrano Molecule 1 in Diabetic Mouse Kidney. X. Zheng, F. Transporters/Channels/Barriers Soroush, E. Hall, P. Adishesha, S. Bhattacharya, M. Kiani, V. Bhalla. Stanford Univ., Temple Univ. Col. of 10:30 Paracellular Transport as an Energy Conservation Engin. and UCSF Sch. of Med. (1282.12) Strategy in Renal Tubule. A. Yu. Kansas Univ. 11:30 Thyroid Hormone Induces Vascular Relaxation through Med. Ctr. VASP Phosphorylation at Serine239: A Potential 11:00 Tight Junction Regulation during Enteric Infection: Therapeutic Approach to Treat Diabetic Vascular Benefits of Increased Permeability. J. Turner. Univ. Dysfunction. S. Samuel, A.M. Gerdes, M.A. Carrillo- of Chicago. Sepulveda. NYIT and NYIT Col. of Osteo. Med. 11:30 Claudins and TAMPS in the Ischemic Blood-Brain Barrier. (1282.11) I. Blasig. Leibniz Inst. of Molec. Pharmacol., Berlin. 11:45 HuR-Mediated HK2 Downregulation Leads to Coronary 12:00 Occludin Regulatory Motif Confers Dynamics and Endothelial Dysfunction in Diabetic Mice. W. Wang, Regulation of Epithelial Tight Junctions. R. Rao. Univ. A.H. Truong, A. Makino. Univ. of Arizona. (1282.2) of Tennessee Hlth. Sci. Ctr. 12:00 Enhanced Mobilization of Endothelial Ca2+ by SKA-31 Contributes to the Restoration of Agonist-Mediated Vasorelaxation in Resistance Arteries from Type 2 Diabetic Rats. B.D. Kyle, R.C. Mishra, A.P. Braun. Cumming Sch. of Med., Univ. of Calgary, Canada. (1282.1) 12:15 Perivascular Adipose Tissue-Derived TNFα Neutralization Recovers Aortic Function in Metabolic Syndrome. E. DeVallance, K. Branyan, K. Lemaster, S. Brooks, S. Asano, R. Skinner, J.C. Frisbee, P.D. Chantler. West Virginia Univ. (1282.7)

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549. RECOVERY FROM EXERCISE AND 11:45 Ventilatory and Neurochemical Effects of Microdialysis TRANSLATING POST-EXERCISE HYPOTENSION of the Ionotropic GABAA Receptor Agonist Into the Ventral Respiratory Column of Awake Featured Topic Goats. T.M. Langer, S. Neumueller, N. Burgraff, E. Crumley, L. Pan, M.R. Hodges, H.V. Forster. Med. (Sponsored by: APS Environmental and Exercise Col. of Wisconsin and Marquette Univ. (1299.8) Physiology Section) 12:00 Ampakines Increase Spinal Respiratory Motor Output Wed. 10:30 am—San Diego Convention Center, Room 28A after Cervical Spinal Cord Injury in Rats. K. Streeter, E. Gonzalez-Rothi, M. Sandhu, D. Baekey, J. Chaired: T. Baynard Greer, D. Fuller. Univ. of Florida and Univ. of Alberta. (1299.4) Exercise, Aging, and Disease 12:15 Effects of A2A and 5-HT2A Antagonists on Hypoxic and 10:30 Clinical Insights into Recovery from Exercise and the Hypercapnic Ventilatory Response in Rats Exposed Relevance of Post-exercise Hypotension. C. Forjaz. to Chronic Sustained Hypoxia. E.A. Moya, F.L. Univ. of São Paulo. Powell. UCSD. (1299.6) 11:00 Influence of Time of Day on Post-exercise Hypotension Might Be Different in Hypertensives Receiving 551. NATURAL PRODUCTS: BIOLOGICAL Different Anti-hypertensive Drugs: An Exploratory EFFECTS AND THERAPEUTIC POTENTIAL IN Study. L. Brito, T. Peçanha, R. Fecchio, P. Sousa, R. HUMAN DISEASE Rezende, M. Navarro, G. Silva, A. Abreu, D. Mion- Junior, C. Forjaz. Univ. of São Paulo. (1291.1) Symposium 11:15 Exaggerated Systolic Blood Pressure Response after Unaccustomed High-Intensity Interval Exercise Is (Sponsored by: American Federation for Independently Related to Decreased Small Arterial Medical Research) Elasticity in Normotensive African American Women. Wed. 2:30 pm—San Diego Convention Center, Room 25A S.J. Carter, T.U. Goldsby, G. Fisher, E.P. Plaisance, B.A. Gower, S.P. Glasser, G.R. Hunter. Univ. of Chaired: S.S. Prabhakar and D. Wu Alabama at Birmingham. (1291.2) 11:30 Effect of Combination Ice and Compression Socks on 2:30 Green Tea and Bone Health: From Bench to Clinical Resting Calf Blood Flow in Trained Male Athletes. Trial. C-L. Shen. Texas Tech Univ. Hlth. Sci. Ctr. M.J. Hudock, J.L. Keller, A.R. Crecelius. Univ. of 3:00 Effects of Curcumin in Experimental Diabetic Dayton. (1291.3) Nephropathy. S. Prabhakar. Texas Tech Univ. Hlth. 11:45 The Effects of Cold Water Immersion on Inflammation, Sci. Ctr. Growth and Neurotrophic Factors in Skeletal Muscle 3:30 Green Tea EGCG, T Cell Function, and T Cell-Mediated after Resistance Exercise. J. Peake, L. Roberts, Autoimmune Diseases. D. Wu. Friedman Sch. of Nutr. T. Raastad, V. Figueiredo, D. Cameron-Smith, Sci. and Policy, Tufts Univ. J. Coombes, J. Markworth. Queensland Univ. of 4:00 Natural Products and Their Applications to Treat Technol., Univ. of Queensland, Norwegian Sch. of Aging and Neurodegenerative Diseases. H. Reddy. Sports Sci., Oslo and Univ. of Auckland. (1291.4) Garrison Inst. of Aging, Texas Tech Univ. 12:00 Mechanistic Insights into Recovery from Exercise and the Cause of Post-Exercise Hypotension. J. Halliwill. 552. ORPHEUS — DEVELOPING BEST PRACTICES Univ. of Oregon. FOR GRADUATE EDUCATION IN EUROPE

550. REDUNDANCY AND PLASTICITY IN Special Session RESPIRATORY CONTROL (Sponsored by: NDOGS)

Featured Topic Wed. 2:30 pm—San Diego Convention Center, Room 25C (Sponsored by: APS Respiration Section) Chaired: J. Barnett

Wed. 10:30 am—San Diego Convention Center, Room 25B 2:30 R. Harris. Karolinska Univ.

Chaired: R. Bavis and N. Nichols

10:30 Oxygen Sensing by Extra-Carotid Chemoreceptors. C. Nurse. McMaster Univ., Canada. 11:00 Role of Central and Peripheral Chemoreceptor Interdependence in the Control of Breathing. G. Blain. Univ. of Nice, Sophia Antipolis, France. 11:30 Loss of the Persistent Sodium Current Elicits Homeostatic Plasticity in Respiratory Rhythm Generation. N.A. Baertsch, S.C. Ramirez, J.M. Ramirez. Seattle Children’s Res. Inst. (1299.10)

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