Weihong Song, MD, Phd (宋伟宏)

T H E U N I V E R S I T Y O F B R I T I S H C O L U M B I A

Weihong Song, MD, PhD (宋伟宏)

Fellow of the Canadian Academy of Health Sciences Jack Brown and Family Professor and Canada Research Chair in Alzheimer’s Disease Senior Advisor to UBC President on China Associate Director, Institute of Mental Health Director, Basic Neuroscience Division, Department of Psychiatry Director, UBC Townsend Family Laboratories

Department of Psychiatry, The University of British Columbia 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada Tel: 604-822-8019, Fax: 604-822-7756, Email: [email protected] Web: http://www.neuroscience.ubc.ca/song.htm

Professional Experience 2017- Senior Advisor to the President on China 2015- Associate Director, Institute of Mental Health 2015- Director, Basic Neuroscience Division, Department of Psychiatry 2012- Canada Research Chair in Alzheimer’s Disease (Tier 1) 2010- Professor (with tenure) 2009-2016 Special Advisor to the President on China 2008- Director, UBC Townsend Family Laboratories 2001- Jack Brown and Family Professorship & Chair in Alzheimer's Disease 2002-2012 Canada Research Chair in Alzheimer’s Disease (Tier 2) 2006-2010 Associate Professor (with tenure), 2004-2008 Postdoctoral Coordinator for Faculty of Medicine 2001-2006 Assistant Professor (tenure track) Department of Psychiatry/Brain Research Center The University of British Columbia, Vancouver, BC, Canada

1999-2001 Instructor 1996-1999 Postdoctoral Research Fellow (Supervisor: Bruce A. Yankner, MD, PhD) Department of Neurology Harvard Medical School, Boston, Massachusetts, USA

1988-1990 Chief Psychiatrist and Lecturer of Psychiatry 1986-1988 Chief Resident Doctor and Assistant Professor of Psychiatry 1983-1986 Psychiatry Residency Department of Psychiatry and Institute of Mental Health The First Affiliated Hospital West China University of Medical Sciences, Chengdu, China

Education 1993-1996 Ph.D., Program of Medical Neurobiology (Supervisor: Debomoy K. Lahiri) Laboratory of Molecular Neurogenetics

T H E U N I V E R S I T Y O F B R I T I S H C O L U M B I A

Institute of Psychiatric Research, Department of Psychiatry Indiana University School of Medicine, Indianapolis, Indiana, USA 1991-1993 M.Sc., Purdue Neuroscience Program (Supervisor: F. Robert Bruch) Psycho-neuro-endocrinology and Behavior Genetics Laboratory Purdue University, West Lafayette, Indiana, USA 1983-1986 M. Medicine (Psychiatry) (Supervisor: Xiehe Liu) Department of Psychiatry, School of Medicine West China University of Medical Sciences, Chengdu, China 1978-1983 B. Medicine Chongqing Medical University, Chongqing, China

Honors and Awards

2014 International Science and Technology Cooperation Award City of Chongqing 2013 Oversea Chinese Delegate, the 12th Chinese People's Political Consultative Conference (CPPCC) National Committee 2013 A Distinguished Achievement Award UBC Faculty of Medicine 2012 Fellow of the Canadian Academy of Health Sciences (CAHS) (The Council of Canadian Academies, formerly the Canadian Academies of Science) 2011 Friendship Award (China's highest honor for foreign experts) The Government of China 2007 A Distinguished Achievement Award UBC Faculty of Medicine 2006 Cheung Kong Scholar (Chair Professor) Ministry of Education of China and Li Ka Shing Foundation 2005 Distinguished (Oversea) Young Scholar National Natural Science Foundation of China 2004 Michael Smith Foundation for Health Research Scholar Michael Smith Foundation for Health Research 2004 in it for life Investigator Awards Vancouver Coastal Health Research Institute 2002 Peter Wall Institute Scholar Peter Wall Institute for Advanced Studies

Member of Editorial Board For Journals 2015-present Scientific Reports 2012-2016 Alzheimer’s Research & Therapy 2009-present Journal of Clinical Investigation 2009-present Journal of Neurochemistry (Handling Editor) 2009-present Current Alzheimer Research (Associate Editor) 2009-present Journal of Molecular Neuroscience 2009-present Frontiers in Molecular Neuroscience

Directly Supervised Graduate Students and Postdoctoral Fellows at UBC PhD students: 27

T H E U N I V E R S I T Y O F B R I T I S H C O L U M B I A

Master Students: 8 Postdoctoral Fellows: 16

Graduate Student Advisory and/or Examination Committees at UBC A supervisor committee member for > 40 PhD and Master Students Chair or member of Examining Committee or University Examiner for 15 PhD and Master Students

Recent Selected Publications (as corresponding author) 1. Zhang S, et al. (2018). A presenilin-1 mutation causes Alzheimer disease without affecting Notch signaling. Molecular Psychiatry, doi: 10.1038/s41380-018-0101-x. 2. Liu F, et al. (2018). Cleavage of potassium channel Kv2.1 by BACE2 reduces neuronal apoptosis. Molecular Psychiatry, 23 (7), 1542-1554.

3. Bu X, et al. (2017). Blood-derived amyloid-β protein induces Alzheimer’s disease pathologies. Molecular Psychiatry, doi: 10.1038/MP.2017.204. 4. Zhang S, et al. (2017). BACE1 cleavage site selection critical for amyloidogenesis and Alzheimer's pathogenesis. Journal of Neuroscience, 37 (29), 6915-6925. 5. Zeng J, et al. (2017). Marginal vitamin A deficiency facilitates Alzheimer’s pathogenesis. Acta Neuropathologica, 133, 967-982. 6. Wang Z, et al. (2016). Nuclear receptor NR1H3 in familial multiple sclerosis. Neuron 90, 948-954. 7. Dong Z, et al. (2015). Activity-dependent AMPAR endocytosis is a critical process for LTP decay and memory loss. Journal of Clinical Investigation 125, 234-247. 8. Wu Y, et al. (2015). Amyloid-β precursor protein facilitates the regulator of calcineurin 1-mediated apoptosis by downregulating proteasome subunit α type-5 and proteasome subunit β type-7. Neurobiology of Aging, 36, 169-177. 9. Zhang S, et al (2014). Downregulation of MIF by NFκB under hypoxia accelerated neuronal loss during stroke. FASEB Journal 28, 4394-4407. 10. Sun X, Wu Y, Herculano B, Song W (2014). RCAN1 overexpression exacerbates calcium overloading-induced neuronal apoptosis. PloS ONE, 9, e95471. 11. Ly PT, et al. (2013). Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer- associated phenotypes. Journal of Clinical Investigation 123, 224–235. 12. Wu Y, Song W (2013). Regulation of RCAN1 translation and its role in oxidative stress-induced apoptosis. FASEB Journal 27, 208-221. 13. Deng Y, et al. (2013). Aβ Glu11 is the major β-secretase site of BACE1 and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis. European Journal of Neuroscience, 37, 1962-1969. 14. Zhang M, et al. (2012). Control of BACE1 degradation and APP processing by ubiquity carboxyl- terminal hydrolyses. Journal of Neurochemistry, 120, 1129-1138. 15. Sun X, et al. (2011). Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase 3 activation. Journal of Biological Chemistry, 286, 9049-9062.