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ADVANCED 6352 CORTE DEL ABETO, STE B CARLSBAD, CA 92011 USA TARGETING 01.858.642.1988 • WWW.ATSBIO.COM SYSTEMS Antibody to ACTH RABBIT POLYCLONAL Catalog Number: AB-09 Quantity: 100 microliters Format: Liquid antisera, no preservative Host: Rabbit Immunogen: Synthetic human ACTH 1-39 Background: Adrenocorticotropic hormone (ACTH or corticotropin) stimulates the adrenal cortex. More specifically, it stimulates secretion of glucocorticoids such as cortisol, and has little control over secretion of aldosterone, the other major steroid hormone from the adrenal cortex. ACTH is secreted from the anterior pituitary in response to corticotropin-releasing hormone from the hypothalamus. The corticotropin-releasing hormone is secreted in response to many types of stress. Specificity and Preparation: This antibody recognizes mammalian ACTH. The immunogen was raised in rabbits against the synthetic human ACTH 1-39. The antibody is routinely tested by dot blot. Usage and Storage: Applications include immunostaining (1:200 to 1:600)1, immunoblotting (ATS in-house; 1:500), immunohistochemistry (fresh or frozen non-fixed sections; personal communication) and radioimmunoassay.2 Store the antibody at 4°C for one month or -20°C in undiluted aliquots for up to one year. Avoid repeated freezing and thawing. Gently spin down material before use; 5-10 seconds in a microfuge should be adequate. References: 1. Bloch B, Gaillard RC, Brazeau P, Lin HD, Ling N (1984) Topographical and ontogenetic study of the neurons producing growth hormone-releasing factor in human hypothalamus. Regul Pept 8(1):21-31. 2. Baird A, Wehrenberg WB, Shibasaki T, Benoit R., Chong-Li Z, Esch F, Ling N. (1982) Ovine corticotropin-releasing factor stimulates the concomitant secretion of corticotropin, beta-lipotropin, beta- endorphin and gamma-melanotropin by the bovine adenohypophysis in vitro. Biochem Biophys Res Commun 108(3):959-964. To view protocol(s) for this and other products please visit: www.ATSbio.com/support/protocols Page 1 For research use only, not for use as a diagnostic. 6/4/07.

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Searching for Novel Peptide Hormones in the Human Genome Olivier Mirabeau
Searching for novel peptide hormones in the human genome Olivier Mirabeau To cite this version: Olivier Mirabeau. Searching for novel peptide hormones in the human genome. Life Sciences [q-bio]. Université Montpellier II - Sciences et Techniques du Languedoc, 2008. English. tel-00340710 HAL Id: tel-00340710 https://tel.archives-ouvertes.fr/tel-00340710 Submitted on 21 Nov 2008 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. UNIVERSITE MONTPELLIER II SCIENCES ET TECHNIQUES DU LANGUEDOC THESE pour obtenir le grade de DOCTEUR DE L'UNIVERSITE MONTPELLIER II Discipline : Biologie Informatique Ecole Doctorale : Sciences chimiques et biologiques pour la santé Formation doctorale : Biologie-Santé Recherche de nouvelles hormones peptidiques codées par le génome humain par Olivier Mirabeau présentée et soutenue publiquement le 30 janvier 2008 JURY M. Hubert Vaudry Rapporteur M. Jean-Philippe Vert Rapporteur Mme Nadia Rosenthal Examinatrice M. Jean Martinez Président M. Olivier Gascuel Directeur M. Cornelius Gross Examinateur Résumé Résumé Cette thèse porte sur la découverte de gènes humains non caractérisés codant pour des précurseurs à hormones peptidiques. Les hormones peptidiques (PH) ont un rôle important dans la plupart des processus physiologiques du corps humain.
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