Impact Factor: 3.958/ICV: 4.10 68 CONCEPT of CONJUGATION

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Impact Factor: 3.958/ICV: 4.10 68 CONCEPT of CONJUGATION Impact factor: 3.958/ICV: 4.10 68 Pharma Science Monitor 8(4), Oct-Dec 2017 PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES Journal home page: http://www.pharmasm.com CONCEPT OF CONJUGATION AND CONFIGURATION OF MAHABHUTAS Bharat L. Bhadiyadra1*, R. R. Dwivedi2, Hitesh A. Vyas3, A. S. Baghel4 1Ph D Scholar, Basic Principles Department, IPGT & RA, Jamnagar, Gujarat, India 2Ex-Professor & Head, Basic Principles Department, IPGT & RA,Gujarat Ayurved University Jamnagar, Gujarat, India 3Associate Professor, Basic Principles Department, IPGT & RA,Gujarat Ayurved University Jamnagar, Gujarat, India 4Associate Professor, Basic Principles Department, IPGT & RA,Gujarat Ayurved University Jamnagar, Gujarat, India ABSTRACT The science of Health, Ayurveda has its own fundamental principles on which all the aspect of health at physical, physiological, psychological & spiritual activity depends. Among all the Basic principles, the Panchabhautika Siddhanta is the scientific base of Ayurveda as Acharya Sushruta quoted, that there is no need to think beyond Panchamahabhutas while treating patients. As per Acharya Charaka, whatever & whichever (Bhavas) existing in this universe are Panchabhautika. The Panchamahabhutas are gross manifestation of the universe and here everything is Panchabhautika though it is different from each other, reason behind it is that their Panchabhautika conjugation & configuration either as quality, quantity or as per arrangement of molecules is different. Here an effort made to elaborate this concept of conjugation and configuration of Mahabhutas. KEYWORDS: Panchamahabhuta, Conjugation, Configuration. INTRODUCTION In present era, every science progresses on its own Siddhantas by adding new concepts & their application in science, using new techniques & advance technology. Every medical science has an aim to provide a good health to the human beings. Now a day new technologies are growing more and more but on the same pattern the health problems are day by day increasing too. Hence it becomes mandatory for the Ayurveda to play here its role as preventive, promotive & curative aspect as oath of this science is[1], The science of Health, Ayurveda also has its own fundamental principles on which all the status of health at physical, physiological, psychological & spiritual activity depends. Among its all the Basic principles, the Panchabhautika Siddhanta is the scientific base of Ayurveda as Acharya Sushruta quoted, that there is no need to think beyond Panchamahabhutas while treating patients[2]. As per Acharya Charaka, whatever & whichever (Bhavas) existing in this universe are Panchabhautika. All the matters existing in this universe are Pancabhautika. Bharat et al. / Pharma Science Monitor 8(4), Oct-Dec 2017, 68-78 Impact factor: 3.958/ICV: 4.10 69 Panchamahabhutas are at the juncture of the subtle to the more gross manifestation of the universe[3]. Here everything is Panchabhautika though it is different from each other, reason behind it is that their Panchabhautika conjugation & configuration either as quality, quantity or as per arrangement of molecules is different. Eg. In chemistry & mathematics different permutation & combinations takes place at molecular & figures level in their specific placement respectively. Aims and objective To elaborate and discuss the concept of conjugation & configuration of Mahabhuta. Materials and Methods Comprehensive review of relevant Ayurvedic and modern literature, previous works, journals and Internet carried out in the light of plan of study. Conceptual study All the matters existing in this universe are Pancabhautika[4]. Panchamahabhutas are at the juncture of the subtle to the more gross manifestation of the universe. The rationale of anything and everything which cannot be explained by Tridodhasha can be very well interpreted by Pancamahabhuta Siddhanta. Pharmacodynamics and pharmacokinetics of Dravya depends on its Panchabhautika conjugation and configuration. Here conjugation means joining or union or mixing. Configuration means the relative arrangement or placement of basic constituents of the substances. To understand the concept of origin of Dravya as a whole, one has to go to its base. So it is mandatory for us to know the things (Karya Dravya) which we are using in our practice, from where they are originated. When describing the evolution of the universe different theories were postulated by the different schools of thought. These theories can be summarized as follows- 1. Evolution of Mahabhutas 2. Formation of Panchabhautika Drayva or (Conjugation & configuration of Mahabhutas) 1. Evolution of Mahabhutas: Evolution of Mahabhutas takes place in following stages: 1st Stage -- Evolution of Panchatanmatra To understand the evolution of Mahabhutas, one first have to know the evolution of basic units of Mahabhutas i.e. Tanmatra . Tanmatra is a subtle quantum of Mahabhuta category having a specific energy or mass. Philosophical sciences defined them as having a material form and not divisible further. Tanmatras evolved in following order, Bharat et al. / Pharma Science Monitor 8(4), Oct-Dec 2017, 68-78 Impact factor: 3.958/ICV: 4.10 70 Avyakta Mahat Ahamkara Satva Rajas Tamas 11 Indriyas 5 Tanmatras Shabda Sparsha Rupa Rasa Gandha Tanmatra Tanmatra Tanmatra Tanmatra Tanmatra In short, evolution of Pancha Tanmatra from the Bhutadi Ahamkara is as follows[5] Bhutadi Ahamkara Shabda Tanmatra Akasha Sparsha Tanmatra Vayu Rupa Tanmatra Agni Rasa Tanmatra Jala Gandha Tanmatra Pruthvi 2nd Stage – Samyoga of Tanmatras – The Tanmatras of each Mahabhutas formed in order of evolution, clog together in a loose surface bonding to form Sukshma Bhutas. Same was described by Vaishesikas in form of formation of Dvayanuka, Trasarenu etc. Bharat et al. / Pharma Science Monitor 8(4), Oct-Dec 2017, 68-78 Impact factor: 3.958/ICV: 4.10 71 3rd Stage -- Bhutantaranupravesha (Imitative Pervasion) -- In this process, Sukshma Bhutas undergo some reactions to form the Mahabhutas. There is invasion of the Paramanus from Akasha Mahabhuta to Pruthvi Mahabhuta in a sequential order as Maharshi Charaka describes, So finally Pruthvi Mahabhuta possesses all the five Gunas [6]. Shabda Tanmatra Akasha Unitanmatric Akasha Shabda Tanmatra Akasha + Sparsha Tanmatra Vayu Bitanmatric Vayu Bitanmatric Vayu + Rupa Tanmatra Agni Tritanmatric Agni Tritanmatric Agni+ Rasa Tanmatra Jala Tetratanmatric Apa Tetratanmatric Apa + Gandha Tanmatra Pruthvi Pentatanmatric Pruthvi Acharya Sushruta also supports this, From the above process it is clear that only Pruthvi Mahabhuta have the fractions of all Sukshma Bhutas so Pruthvi Mahabhuta alone is gross and stable. Other four Mahabhutas don’t have enough Murtatva to stand without the combination of Pruthvi Mahabhuta[7]. 2. Formation of Panchabhautika Drayva (Conjugation & configuration of Mahabhutas) : Mahabhutas formed by the process of Anyonyanupravesha undergo various physical & chemical reactions to form different Panchabhautika Dravyas having different permutation and combinations of Mahabhutas. These physicochemical reactions are called as conjugation and configuration of Mahabhutas. Thus the process of formation of Panchabhautika Drayva is, Tanmatra Sukshma Bhutas Mahabhuta Panchabhautika Dravya CONJUGATION OF MAHABHUTAS -- It means the Samyoga of Pancha Mahabhutas, which is responsible for the formation of Dravyas. How it exactly happens, is not clearly mentioned in classics, but the term Panchikarana can be taken here for explanation. Panchikarana -- The process, by which the Mahabhutas so formed, by the Bhutantaranupravesha of Tanmatra, undergo specific procedures of conjugation to form the manifested Panchabhautika Drayvas of the universe around us, is called as Pancikarana. It is the Panchikarana which is responsible for the manifestation of the Gunas of all Mahabhutas in the Dravya. Bharat et al. / Pharma Science Monitor 8(4), Oct-Dec 2017, 68-78 Impact factor: 3.958/ICV: 4.10 72 The word Panchikarana as such is not mentioned in the classical texts. Samhitakaras and the Tikakaras have not explained much about the reactions taking place in between Mahabhutas. Moreover Acharya Chakrapani says that, these reactions of Mahabhutas (Mahabhuta Sannivesha) takes place due to some unknown force i.e. Adrusta[8]. This terminology and the process behind Panchikarana though found in Paingal Upanishada, but was first conceptualized by Shankaracharya, in his book ‘Pancikarana’, and still elaborated in its commentary, written by Sureshwaracharya[9]. Process of Panchikarana by Vedanta[10]: i) Each molecule of Mahabhutas, formed in the reaction of Bhutantaranupravesha divides into two parts. These parts may not be always equal. ii) The first part of division again divides into four parts; these 4 parts also may not be necessarily in equal proportions. Thus it can be said that all Dravyas formed by the Panchikarana of Mahabhutas have fractions of all the five Mahabhutas, but the proportion or quantity of different Mahabhutas is different in all Dravyas, causing change in properties from one-another[11]. It can be called as Tara-Tamata of Mahabhutas in different Dravyas, which is also explained in case of Doshas and Rasas also. Though all Dravyas possess all the six Rasa, but due to different proportion 63 types of combination are given[12]. Similarly in case of Vikaras also, though all the Rogas are caused by three Doshas but due to their Tara-Tamata and Samyoga vaishistya, 62 types of combinations are described[13]. Even after this, it is again said
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