DOCSLIB.ORG

VA/Dod CLINICAL PRACTICE GUIDELINE for TH MANAGEMENT O DYSLIPIDEMIA for CARDIOVASCULAR RISK REDUCTION Department of Veterans Affairs Department of Defense

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
VA/Dod CLINICAL PRACTICE GUIDELINE for TH MANAGEMENT O DYSLIPIDEMIA for CARDIOVASCULAR RISK REDUCTION Department of Veterans Affairs Department of Defense E F VA/DoD CLINICAL PRACTICE GUIDELINE FOR TH MANAGEMENT O DYSLIPIDEMIA FOR CARDIOVASCULAR RISK REDUCTION Department of Veterans Affairs Department of Defense QUALIFYING STATEMENTS The Department of Veterans Affairs and the Department of Defense guidelines are based upon the best information available at the time of publication. They are designed to provide information and assist decision-making. They are not intended to define a standard of care and should not be construed as one. Neither should they be interpreted as prescribing an exclusive course of management. This Clinical Practice Guideline is based on a systematic review of both clinical and epidemiologic evidence. Developed by a panel of multidisciplinary experts (all practicing clinicians), it provides a clear explanation of the logical relationships between various care options and health outcomes while rating both the quality of the evidence and the strength of the recommendations. Variations in practice will inevitably and appropriately occur when clinicians take into account the needs of individual patients, available resources, and limitations unique to an institution or type of practice. Every health care professional making use of these guidelines is responsible for evaluating the appropriateness of applying them in the setting of any particular clinical situation. These guidelines are not intended to represent TRICARE policy. Further, inclusion of recommendations for specific testing and/or therapeutic interventions within these guidelines does not guarantee coverage of civilian sector care. Additional information on current TRICARE benefits may be found at www.tricare.mil or by contacting your regional TRICARE Managed Care Support Contractor. Version 3.0—2014 December 2014 Page 1 of 112 Table of Contents Background ................................................................................................................................................... 4 About this Clinical Practice Guideline ........................................................................................................... 5 Scope of this CPG .......................................................................................................................................... 5 Population ................................................................................................................................................. 5 Methods ........................................................................................................................................................ 6 Conflict of Interest ........................................................................................................................................ 7 Patient-Centered Care .................................................................................................................................. 7 Algorithm ...................................................................................................................................................... 7 Populations Excluded from this Guideline .................................................................................................. 10 Reconciling 2006 CPG Recommendations .................................................................................................. 11 Implementation .......................................................................................................................................... 12 Guideline Working Group ........................................................................................................................... 13 Recommendations ...................................................................................................................................... 14 Future Research Needs ............................................................................................................................... 18 Assessment of Cardiovascular Risk and Pharmacotherapy for Primary Prevention .................................. 18 Statins ................................................................................................................................................. 22 Fibrates (gemfibrozil, fenofibrate) ...................................................................................................... 25 Bile acid sequestrants ......................................................................................................................... 26 Niacin .................................................................................................................................................. 26 Ezetimibe ............................................................................................................................................ 26 Long Chain Omega-3 Fatty Acids (Fish oils) ........................................................................................ 26 Management of Pharmacotherapy for Secondary Prevention ................................................................... 29 Statins ................................................................................................................................................. 29 Fibrates (gemfibrozil, fenofibrate) ...................................................................................................... 32 Bile acid sequestrants ......................................................................................................................... 32 Niacin .................................................................................................................................................. 33 Ezetimibe ............................................................................................................................................ 33 Long Chain Omega-3 Fatty Acids (Fish oils) ........................................................................................ 33 Non-Pharmacologic Approaches................................................................................................................. 35 Therapeutic Lifestyle Changes Diet..................................................................................................... 35 Weight Loss ......................................................................................................................................... 36 Physical Activity .................................................................................................................................. 36 Smoking Cessation .............................................................................................................................. 36 Nutrition Counseling ........................................................................................................................... 37 Mediterranean Diet ............................................................................................................................ 37 Monitoring and Follow-up .......................................................................................................................... 40 Appendix A: Evidence Review Methodology .............................................................................................. 41 Population(s) ............................................................................................................................................... 41 Interventions ............................................................................................................................................... 42 December 2014 Page 2 of 112 Outcomes .................................................................................................................................................... 42 Conducting the Systematic Review ............................................................................................................. 42 Criteria for Study Inclusion/Exclusion ......................................................................................................... 45 General Criteria ....................................................................................................................................... 45 Treatment Goals (LDL-C and non-LDL-C Target Levels) (KQ 1-2) ............................................................ 45 Effectiveness and Safety of Cholesterol-modifying Drugs (KQ 3) ........................................................... 45 Cost-effectiveness of Cholesterol-modifying Drugs (KQ 4) ..................................................................... 45 Additional Risk Stratifying Tests (KQ 6) ................................................................................................... 46 Supplementary Key Question (KQ7) ....................................................................................................... 46 Literature Search Strategy ...................................................................................................................... 46 Electronic Database Searches ............................................................................................................. 46 Hand Searches of Journal and Gray Literature ................................................................................... 47 Topic-specific Search Terms ................................................................................................................ 47 Search Strategies ...............................................................................................................................
Load more

Recommended publications
  • United States Patent (19) 11 Patent Number: 6,066,653 Gregg Et Al
    US006066653A United States Patent (19) 11 Patent Number: 6,066,653 Gregg et al. (45) Date of Patent: May 23, 2000 54 METHOD OF TREATING ACID LIPASE FOREIGN PATENT DOCUMENTS DEFICIENCY DISEASES WITH AN MTP 643057A1 3/1995 European Pat. Off.. INHIBITOR AND CHOLESTEROL WO96/26205 8/1996 WIPO. LOWERING DRUGS OTHER PUBLICATIONS 75 Inventors: Richard E. Gregg, Pennington, N.J.; John R. Wetterau, II, Langhorne, Pa. Scriver et all “The Metabolic and Molecular Bases of Inher ited Disease”, Seventh Edition, vol. II, Chapter 82, "Acid 73 Assignee: Bristol-Myers Squibb Co., Princeton, Lipase Deficiency: Wolman Disease and Cholesteryl Ester N.J. Storage Disease”, pp. 2563–2587, (1995). Scriver et all “The Metabolic and Molecular Bases of Inher 21 Appl. No.: 09/005,437 ited Disease”, Seventh Edition, vol. II, Chapter 85, 22 Filed: Jan. 10, 1998 “Niemann-Pick Disease Type C: A Cellular Cholesterol Lipidosis”, pp. 2625–2639, (1995). Related U.S. Application Data 60 Provisional application No. 60/036,183, Jan. 17, 1997. Primary Examiner Kimberly Jordan 51) Int. Cl." ......................... A61K 3.144s. A61k 3/21 Attorney, Agent, or Firm Burton Rodney; Ronald S. 52 U.S. Cl. ........................... s14/325.514,510,514824. "a" 58 Field of Search ..................................... 514/325, 510, 57 ABSTRACT 514/824 A method is provided for inhibiting- - - - - - - or treating diseases 56) References Cited asSociated with acid lipase deficiency by administering to a patient an MTP inhibitor, alone or optionally, in combination U.S. PATENT DOCUMENTS with another cholesterol lowering drug, Such as pravastatin. 4,346,227 8/1982 Terahara et al. ........................ 560/119 5,712,279 1/1998 Biller et al.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2004/0224012 A1 Suvanprakorn Et Al
    US 2004O224012A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2004/0224012 A1 Suvanprakorn et al. (43) Pub. Date: Nov. 11, 2004 (54) TOPICAL APPLICATION AND METHODS Related U.S. Application Data FOR ADMINISTRATION OF ACTIVE AGENTS USING LIPOSOME MACRO-BEADS (63) Continuation-in-part of application No. 10/264,205, filed on Oct. 3, 2002. (76) Inventors: Pichit Suvanprakorn, Bangkok (TH); (60) Provisional application No. 60/327,643, filed on Oct. Tanusin Ploysangam, Bangkok (TH); 5, 2001. Lerson Tanasugarn, Bangkok (TH); Suwalee Chandrkrachang, Bangkok Publication Classification (TH); Nardo Zaias, Miami Beach, FL (US) (51) Int. CI.7. A61K 9/127; A61K 9/14 (52) U.S. Cl. ............................................ 424/450; 424/489 Correspondence Address: (57) ABSTRACT Eric G. Masamori 6520 Ridgewood Drive A topical application and methods for administration of Castro Valley, CA 94.552 (US) active agents encapsulated within non-permeable macro beads to enable a wider range of delivery vehicles, to provide longer product shelf-life, to allow multiple active (21) Appl. No.: 10/864,149 agents within the composition, to allow the controlled use of the active agents, to provide protected and designable release features and to provide visual inspection for damage (22) Filed: Jun. 9, 2004 and inconsistency. US 2004/0224012 A1 Nov. 11, 2004 TOPCAL APPLICATION AND METHODS FOR 0006 Various limitations on the shelf-life and use of ADMINISTRATION OF ACTIVE AGENTS USING liposome compounds exist due to the relatively fragile LPOSOME MACRO-BEADS nature of liposomes. Major problems encountered during liposome drug Storage in vesicular Suspension are the chemi CROSS REFERENCE TO OTHER cal alterations of the lipoSome compounds, Such as phos APPLICATIONS pholipids, cholesterols, ceramides, leading to potentially toxic degradation of the products, leakage of the drug from 0001) This application claims the benefit of U.S.
    [Show full text]
  • HMG-Coa Reductase (HMGCR)
    HMG-CoA Reductase (HMGCR) HMG-CoA Reductase (HMGCR) is the rate-limiting enzyme for cholesterol synthesis in the conversion of HMG-CoA to mevalonate. HMGCR is found in eukaryotes and prokaryotes. The phylogenetic analysis has revealed two classes of HMG-CoA reductase, the Class I enzymes of eukaryotes and some archaea and the Class II enzymes of eubacteria and certain other archaea. Both in eukaryotes and in archaebacteria the enzyme HMGCR is known to catalyze an early reaction unique to isoprenoid biosynthesis. In humans, the HMG-CoA reductase reaction is rate-limiting for the biosynthesis of cholesterol and therefore constitutes a prime target of drugs that reduce serum cholesterol levels. www.MedChemExpress.com 1 HMG-CoA Reductase (HMGCR) Inhibitors (3R,5R)-Rosuvastatin (3R,5S)-Fluvastatin Cat. No.: HY-17504C ((3R,5S)-XU 62-320 free acid) Cat. No.: HY-14664B (3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of (3R,5S)-Fluvastatin is the Rosuvastatin. Rosuvastatin is a competitive 3R,5S-isomer Fluvastatin. Fluvastatin (XU HMG-CoA reductase inhibitor with an IC50 of 11 62-320 free acid) is a first fully synthetic, nM. Rosuvastatin potently blocks human competitive HMG-CoA reductase inhibitor with ether-a-go-go related gene (hERG) current with an an IC50 of 8 nM. IC50 of 195 nM. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg (3S,5R)-Fluvastatin D6 sodium (3S,5R)-Fluvastatin sodium ((3S,5R)-XU 62-320 D6) Cat. No.: HY-14664CS ((3S,5R)-XU 62-320) Cat.
    [Show full text]
  • The Effectiveness of Statins for Primary Prevention: a Rapid Review
    The Effectiveness of Statins for Primary Prevention: A Rapid Review A Schaink February 2013 Effectiveness of Statins for Primary Prevention: A Rapid Review. February 2013; pp. 1–23. Suggested Citation This report should be cited as follows: Schaink A. The effectiveness of statins for primary prevention: a rapid review. Toronto, ON: Health Quality Ontario; 2013 Feb. 23 p. Available from: http://www.hqontario.ca/evidence/publications-and-ohtac- recommendations/rapid-reviews. Conflict of Interest Statement All reports prepared by the Division of Evidence Development and Standards at Health Quality Ontario are impartial. There are no competing interests or conflicts of interest to declare. Rapid Review Methodology Clinical questions are developed by the Division of Evidence Development and Standards at Health Quality Ontario in consultation with experts, end-users, and/or applicants in the topic area. A systematic literature search is then conducted to identify relevant systematic reviews, health technology assessments, and meta-analyses; if none are located, the search is expanded to include randomized controlled trials (RCTs), and guidelines. Systematic reviews are evaluated using a rating scale developed for this purpose. If the systematic review has evaluated the included primary studies using the GRADE Working Group criteria (http://www.gradeworkinggroup.org/index.htm), the results are reported and the rapid review process is complete. If the systematic review has not evaluated the primary studies using GRADE, the primary studies included in the systematic review are retrieved and a maximum of two outcomes are graded. If no well-conducted systematic reviews are available, RCTs and/or guidelines are evaluated. Because rapid reviews are completed in very short timeframes, other publication types are not included.
    [Show full text]
  • Partial Agreement in the Social and Public Health Field
    COUNCIL OF EUROPE COMMITTEE OF MINISTERS (PARTIAL AGREEMENT IN THE SOCIAL AND PUBLIC HEALTH FIELD) RESOLUTION AP (88) 2 ON THE CLASSIFICATION OF MEDICINES WHICH ARE OBTAINABLE ONLY ON MEDICAL PRESCRIPTION (Adopted by the Committee of Ministers on 22 September 1988 at the 419th meeting of the Ministers' Deputies, and superseding Resolution AP (82) 2) AND APPENDIX I Alphabetical list of medicines adopted by the Public Health Committee (Partial Agreement) updated to 1 July 1988 APPENDIX II Pharmaco-therapeutic classification of medicines appearing in the alphabetical list in Appendix I updated to 1 July 1988 RESOLUTION AP (88) 2 ON THE CLASSIFICATION OF MEDICINES WHICH ARE OBTAINABLE ONLY ON MEDICAL PRESCRIPTION (superseding Resolution AP (82) 2) (Adopted by the Committee of Ministers on 22 September 1988 at the 419th meeting of the Ministers' Deputies) The Representatives on the Committee of Ministers of Belgium, France, the Federal Republic of Germany, Italy, Luxembourg, the Netherlands and the United Kingdom of Great Britain and Northern Ireland, these states being parties to the Partial Agreement in the social and public health field, and the Representatives of Austria, Denmark, Ireland, Spain and Switzerland, states which have participated in the public health activities carried out within the above-mentioned Partial Agreement since 1 October 1974, 2 April 1968, 23 September 1969, 21 April 1988 and 5 May 1964, respectively, Considering that the aim of the Council of Europe is to achieve greater unity between its members and that this
    [Show full text]
  • (CPG) for the Management of Dyslipidemia for Cardiovascular
    VA/DoD CLINICAL PRACTICE GUIDELINE FOR THE MANAGEMENT OF DYSLIPIDEMIA FOR CARDIOVASCULAR RISK REDUCTION Department of Veterans Affairs Department of Defense QUALIFYING STATEMENTS The Department of Veterans Affairs and the Department of Defense guidelines are based upon the best information available at the time of publication. They are designed to provide information and assist decision making. They are not intended to define a standard of care and should not be construed as one. Neither should they be interpreted as prescribing an exclusive course of management. This Clinical Practice Guideline is based on a systematic review of both clinical trial and epidemiological evidence. Developed by a panel of multidisciplinary experts, it provides a clear explanation of the logical relationships between various care options and health outcomes while rating both the quality of the evidence and the strength of the recommendation. Variations in practice will inevitably and appropriately occur when clinicians take into account the needs of individual patients, available resources, and limitations unique to an institution or type of practice. Every healthcare professional making use of these guidelines is responsible for evaluating the appropriateness of applying them in the setting of any particular clinical situation. These guidelines are not intended to represent Department of Veterans Affairs nor TRICARE policy. Further, inclusion of recommendations for specific testing and/or therapeutic interventions within these guidelines does not guarantee coverage. Additional information on current TRICARE benefits may be found at www.tricare.mil or by contacting your regional TRICARE Managed Care Support Contractor. Version 4.0 – 2020 VA/DoD Clinical Practice Guideline for the Management of Dyslipidemia for Cardiovascular Risk Reduction Prepared by: The Management of Dyslipidemia for Cardiovascular Risk Reduction Work Group With support from: The Office of Quality and Patient Safety, VA, Washington, DC & Office of Evidence Based Practice, U.S.
    [Show full text]
  • Regulation of Pharmaceutical Prices: Evidence from a Reference Price Reform in Denmark
    A Service of Leibniz-Informationszentrum econstor Wirtschaft Leibniz Information Centre Make Your Publications Visible. zbw for Economics Kaiser, Ulrich; Mendez, Susan J.; Rønde, Thomas Working Paper Regulation of pharmaceutical prices: Evidence from a reference price reform in Denmark ZEW Discussion Papers, No. 10-062 Provided in Cooperation with: ZEW - Leibniz Centre for European Economic Research Suggested Citation: Kaiser, Ulrich; Mendez, Susan J.; Rønde, Thomas (2010) : Regulation of pharmaceutical prices: Evidence from a reference price reform in Denmark, ZEW Discussion Papers, No. 10-062, Zentrum für Europäische Wirtschaftsforschung (ZEW), Mannheim This Version is available at: http://hdl.handle.net/10419/41440 Standard-Nutzungsbedingungen: Terms of use: Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Documents in EconStor may be saved and copied for your Zwecken und zum Privatgebrauch gespeichert und kopiert werden. personal and scholarly purposes. Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle You are not to copy documents for public or commercial Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich purposes, to exhibit the documents publicly, to make them machen, vertreiben oder anderweitig nutzen. publicly available on the internet, or to distribute or otherwise use the documents in public. Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, If the documents have been made available under an Open gelten abweichend von diesen Nutzungsbedingungen die in der dort Content Licence (especially Creative Commons Licences), you genannten Lizenz gewährten Nutzungsrechte. may exercise further usage rights as specified in the indicated licence. www.econstor.eu Dis cus si on Paper No. 10-062 Regulation of Pharmaceutical Prices: Evidence from a Reference Price Reform in Denmark Ulrich Kaiser, Susan J.
    [Show full text]
  • Screening for Lipid Disorders in Children and Adolescents: Systematic Evidence Review for the U.S
    Evidence Synthesis________________________________________ Number 47 Screening for Lipid Disorders in Children and Adolescents: Systematic Evidence Review for the U.S. Preventive Services Task Force Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 540 Gaither Road Rockville, MD 20850 www.ahrq.gov Contract Number 290-02-0024, Task Order Number 1 Prepared by: Oregon Evidence-based Practice Center Oregon Health and Science University 3181 SW Sam Jackson Park Road Portland, Oregon 97239 www.ohsu.edu/epc/usptf/index.htm Investigators: Elizabeth M. Haney, MD Laurie Hoyt Huffman, MS Christina Bougatsos, BS Michele Freeman, MPH Rongwei Fu, PhD Robert D. Steiner, MD Mark Helfand, MD, MPH Heidi D. Nelson, MD, MPH AHRQ Publication No. 07-0598-EF-1 July 2007 DISCLAIMERS This report is based on research conducted by the Oregon Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-02-0024). The findings and conclusions in this document are those of the authors, who are responsible for its content, and do not necessarily represent the views of AHRQ. No statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services. The information in this report is intended to help clinicians, employers, policymakers, and others make informed decisions about the provision of health care services. This report is intended as a reference and not as a substitute for clinical judgment. This report may be used, in whole or in part, as the basis for the development of clinical practice guidelines and other quality enhancement tools, or as a basis for reimbursement and coverage policies.
    [Show full text]
  • Metabolic Enzyme/Protease
    Inhibitors, Agonists, Screening Libraries www.MedChemExpress.com Metabolic Enzyme/Protease Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of natural product small molecules within a cell or tissue. In each pathway, enzymes catalyze the conversion of substrates into structurally similar products. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. Metabolism maintains the living state of the cells and the organism. Proteases are used throughout an organism for various metabolic processes. Proteases control a great variety of physiological processes that are critical for life, including the immune response, cell cycle, cell death, wound healing, food digestion, and protein and organelle recycling. On the basis of the type of the key amino acid in the active site of the protease and the mechanism of peptide bond cleavage, proteases can be classified into six groups: cysteine, serine, threonine, glutamic acid, aspartate proteases, as well as matrix metalloproteases. Proteases can not only activate proteins such as cytokines, or inactivate them such as numerous repair proteins during apoptosis, but also expose cryptic sites, such as occurs with β-secretase during amyloid precursor protein processing, shed various transmembrane proteins such as occurs with metalloproteases and cysteine proteases, or convert receptor agonists into antagonists and vice versa such as chemokine conversions carried out by metalloproteases, dipeptidyl peptidase IV and some cathepsins. In addition to the catalytic domains, a great number of proteases contain numerous additional domains or modules that substantially increase the complexity of their functions.
    [Show full text]
  • Australian Statistics on Medicines 1997 Commonwealth Department of Health and Family Services
    Australian Statistics on Medicines 1997 Commonwealth Department of Health and Family Services Australian Statistics on Medicines 1997 i © Commonwealth of Australia 1998 ISBN 0 642 36772 8 This work is copyright. Apart from any use as permitted under the Copyright Act 1968, no part may be repoduced by any process without written permission from AusInfo. Requests and enquiries concerning reproduction and rights should be directed to the Manager, Legislative Services, AusInfo, GPO Box 1920, Canberra, ACT 2601. Publication approval number 2446 ii FOREWORD The Australian Statistics on Medicines (ASM) is an annual publication produced by the Drug Utilisation Sub-Committee (DUSC) of the Pharmaceutical Benefits Advisory Committee. Comprehensive drug utilisation data are required for a number of purposes including pharmacosurveillance and the targeting and evaluation of quality use of medicines initiatives. It is also needed by regulatory and financing authorities and by the Pharmaceutical Industry. A major aim of the ASM has been to put comprehensive and valid statistics on the Australian use of medicines in the public domain to allow access by all interested parties. Publication of the Australian data facilitates international comparisons of drug utilisation profiles, and encourages international collaboration on drug utilisation research particularly in relation to enhancing the quality use of medicines and health outcomes. The data available in the ASM represent estimates of the aggregate community use (non public hospital) of prescription medicines in Australia. In 1997 the estimated number of prescriptions dispensed through community pharmacies was 179 million prescriptions, a level of increase over 1996 of only 0.4% which was less than the increase in population (1.2%).
    [Show full text]
  • Lipid Screening in Childhood and Adolescence For
    Supplementary Online Content Lozano P, Henrikson NB, Dunn J, et al. Lipid screening in childhood and adolescence for detection of familial hypercholesterolemia: evidence report and systematic review for the US Preventive Services Task Force. JAMA. doi:10.1001/jama.2016.6176. eTable 1. Diagnostic Criteria for FH: MEDPED Criteria (U.S.) eTable 2. Diagnostic Criteria for FH: Simon Broome Criteria (U.K.) eTable 3. Diagnostic Criteria for FH: Dutch Criteria (The Netherlands) eTable 4. Quality Assessment Criteria eFigure. Literature Flow Diagram eTable 5. Adverse Effects Reported in Studies of Pravastatin (Key Question 7) eTable 6. Adverse Effects Reported in Studies of Other Statins (Key Question 7) eTable 7. Adverse Effects Reported in Studies of Bile Acid–Sequestering Agents and Other Drugs (Key Question 7) This supplementary material has been provided by the authors to give readers additional information about their work. © 2016 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 10/01/2021 eMethods. Literature Search Strategies Search Strategy Sources searched: Cochrane Central Register of Controlled Clinical Trials, via Wiley Medline, via Ovid PubMed, publisher-supplied Key: / = MeSH subject heading $ = truncation ti = word in title ab = word in abstract adj# = adjacent within x number of words pt = publication type * = truncation ae = adverse effects ci = chemically induced de=drug effects mo=mortality nm = name of substance Cochrane Central Register of Controlled Clinical Trials #1 (hyperlipid*emia*:ti,ab,kw
    [Show full text]
  • Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DIX to the HTSUS—Continued
    20558 Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DEPARMENT OF THE TREASURY Services, U.S. Customs Service, 1301 TABLE 1.ÐPHARMACEUTICAL APPEN- Constitution Avenue NW, Washington, DIX TO THE HTSUSÐContinued Customs Service D.C. 20229 at (202) 927±1060. CAS No. Pharmaceutical [T.D. 95±33] Dated: April 14, 1995. 52±78±8 ..................... NORETHANDROLONE. A. W. Tennant, 52±86±8 ..................... HALOPERIDOL. Pharmaceutical Tables 1 and 3 of the Director, Office of Laboratories and Scientific 52±88±0 ..................... ATROPINE METHONITRATE. HTSUS 52±90±4 ..................... CYSTEINE. Services. 53±03±2 ..................... PREDNISONE. 53±06±5 ..................... CORTISONE. AGENCY: Customs Service, Department TABLE 1.ÐPHARMACEUTICAL 53±10±1 ..................... HYDROXYDIONE SODIUM SUCCI- of the Treasury. NATE. APPENDIX TO THE HTSUS 53±16±7 ..................... ESTRONE. ACTION: Listing of the products found in 53±18±9 ..................... BIETASERPINE. Table 1 and Table 3 of the CAS No. Pharmaceutical 53±19±0 ..................... MITOTANE. 53±31±6 ..................... MEDIBAZINE. Pharmaceutical Appendix to the N/A ............................. ACTAGARDIN. 53±33±8 ..................... PARAMETHASONE. Harmonized Tariff Schedule of the N/A ............................. ARDACIN. 53±34±9 ..................... FLUPREDNISOLONE. N/A ............................. BICIROMAB. 53±39±4 ..................... OXANDROLONE. United States of America in Chemical N/A ............................. CELUCLORAL. 53±43±0
    [Show full text]