Thalamic Interaction Between the Input and the Output Systems of the Basal Ganglia
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MRI Atlas of the Human Deep Brain Jean-Jacques Lemaire
MRI Atlas of the Human Deep Brain Jean-Jacques Lemaire To cite this version: Jean-Jacques Lemaire. MRI Atlas of the Human Deep Brain. 2019. hal-02116633 HAL Id: hal-02116633 https://hal.uca.fr/hal-02116633 Preprint submitted on 1 May 2019 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives| 4.0 International License MRI ATLAS of the HUMAN DEEP BRAIN Jean-Jacques Lemaire, MD, PhD, neurosurgeon, University Hospital of Clermont-Ferrand, Université Clermont Auvergne, CNRS, SIGMA, France This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA. Terminologia Foundational Model Terminologia MRI Deep Brain Atlas NeuroNames (ID) neuroanatomica usages, classical and french terminologies of Anatomy (ID) Anatomica 1998 (ID) 2017 http://fipat.library.dal.ca In -
Regional Cerebral Glucose Utilization During Morphine Withdrawal in the Rat (Cerebral Metabolism/Limbic System/Drug Dependence) G
Proc. Natl Acad. Sci. USA Vol. 79, pp. 3360-3364, May 1982 Neurobiology Regional cerebral glucose utilization during morphine withdrawal in the rat (cerebral metabolism/limbic system/drug dependence) G. F. WOOTEN, P. DISTEFANO, AND R. C. COLLINS Departments of Neurology and Pharmacology, Division of Clinical Neuropharmacology, Washington University School of Medicine, St. Louis, Missouri 63110 Communicated by Oliver H. Lowry, February 26, 1982 ABSTRACT Regional cerebral glucose utilization was studied precipitated morphine withdrawal in the rat. A preliminary re- by 2-deoxy['4C]glucose autoradiography in morphine-dependent port of this work has appeared as an abstract (17). rats and during naloxone-induced morphine withdrawal. In mor- phine-dependent rats, glucose utilization was increased compared MATERIALS AND METHODS with naive controls uniformly (23-54%) in hippocampus, dentate gyrus, and subiculum and reduced in frontal cortex, striatum, an- Preparation of Animals. Male Sprague-Dawley rats weigh- terior ventral thalamus, and medial habenular nucleus. On pre- ing 275-325 g were used. On experimental day 1, a single pellet cipitation ofmorphine withdrawal by subcutaneous administration containing 75 mg of morphine as free base was implanted sub- of naloxone at 0.5 mg/kg to morphine-dependent rats, glucose cutaneously under light ether anesthesia. On day 4, two pellets, utilization was increased in the central nucleus ofamygdala (51%), each containing 75 mg of morphine as free base, were im- lateral mammillary nucleus (40%), lateral habenular nucleus planted. On day 7, after being deprived of food for 12 hr, the (39%), medial mammillary nucleus (35%), and medial septal nu- rats were lightly anesthetized with 2% halothane, the pellets cleus (35%) (all, P < 0.01). -
Neural Plasticity in the Brain During Neuropathic Pain
biomedicines Review Neural Plasticity in the Brain during Neuropathic Pain Myeong Seong Bak 1, Haney Park 1 and Sun Kwang Kim 1,2,* 1 Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea; [email protected] (M.S.B.); [email protected] (H.P.) 2 Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea * Correspondence: [email protected]; Tel.: +82-2-961-0491 Abstract: Neuropathic pain is an intractable chronic pain, caused by damage to the somatosensory nervous system. To date, treatment for neuropathic pain has limited effects. For the development of efficient therapeutic methods, it is essential to fully understand the pathological mechanisms of neuropathic pain. Besides abnormal sensitization in the periphery and spinal cord, accumulating evidence suggests that neural plasticity in the brain is also critical for the development and mainte- nance of this pain. Recent technological advances in the measurement and manipulation of neuronal activity allow us to understand maladaptive plastic changes in the brain during neuropathic pain more precisely and modulate brain activity to reverse pain states at the preclinical and clinical levels. In this review paper, we discuss the current understanding of pathological neural plasticity in the four pain-related brain areas: the primary somatosensory cortex, the anterior cingulate cortex, the periaqueductal gray, and the basal ganglia. We also discuss potential treatments for neuropathic pain based on the modulation of neural plasticity in these brain areas. Keywords: neuropathic pain; neural plasticity; primary somatosensory cortex; anterior cingulate cortex; periaqueductal grey; basal ganglia Citation: Bak, M.S.; Park, H.; Kim, S.K. -
Magnetic Resonance Imaging of Mediodorsal, Pulvinar, and Centromedian Nuclei of the Thalamus in Patients with Schizophrenia
ORIGINAL ARTICLE Magnetic Resonance Imaging of Mediodorsal, Pulvinar, and Centromedian Nuclei of the Thalamus in Patients With Schizophrenia Eileen M. Kemether, MD; Monte S. Buchsbaum, MD; William Byne, MD, PhD; Erin A. Hazlett, PhD; Mehmet Haznedar, MD; Adam M. Brickman, MPhil; Jimcy Platholi, MA; Rachel Bloom Background: Postmortem and magnetic resonance im- reduced in all 3 nuclei; differences in relative reduction aging (MRI) data have suggested volume reductions in did not differ among the nuclei. The remainder of the the mediodorsal (MDN) and pulvinar nuclei (PUL) of the thalamic volume (whole thalamus minus the volume of thalamus. The centromedian nucleus (CMN), impor- the 3 delineated nuclei) was not different between schizo- tant in attention and arousal, has not been previously stud- phrenic patients and controls, indicating that the vol- ied with MRI. ume reduction was specific to these nuclei. Volume rela- tive to brain size was reduced in all 3 nuclei and remained Methods: A sample of 41 patients with schizophrenia significant when only patients who had never been ex- (32 men and 9 women) and 60 healthy volunteers (45 posed to neuroleptic medication (n=15) were consid- men and 15 women) underwent assessment with high- ered. For the MDN, women had larger relative volumes resolution 1.2-mm thick anatomical MRI. Images were than men among controls, but men had larger volumes differentiated to enhance the edges and outline of the than women among schizophrenic patients. whole thalamus, and the MDN, PUL, and CMN were out- lined on all slices by a tracer masked to diagnostic Conclusions: Three association regions of the thala- status. -
Neural Circuit and Clinical Insights from Intraoperative Recordings During Deep Brain Stimulation Surgery
brain sciences Perspective Neural Circuit and Clinical Insights from Intraoperative Recordings During Deep Brain Stimulation Surgery Anand Tekriwal 1,2,3 , Neema Moin Afshar 2, Juan Santiago-Moreno 3, Fiene Marie Kuijper 4, Drew S. Kern 1,5, Casey H. Halpern 4, Gidon Felsen 2 and John A. Thompson 1,5,* 1 Department of Neurosurgery, University of Colorado School of Medicine, Aurora, CO 80203, USA 2 Department of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO 80203, USA 3 Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, CO 80203, USA 4 Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA 5 Department of Neurology, University of Colorado School of Medicine, Aurora, CO 80203, USA * Correspondence: [email protected] Received: 28 June 2019; Accepted: 18 July 2019; Published: 20 July 2019 Abstract: Observations using invasive neural recordings from patient populations undergoing neurosurgical interventions have led to critical breakthroughs in our understanding of human neural circuit function and malfunction. The opportunity to interact with patients during neurophysiological mapping allowed for early insights in functional localization to improve surgical outcomes, but has since expanded into exploring fundamental aspects of human cognition including reward processing, language, the storage and retrieval of memory, decision-making, as well as sensory and motor processing. The increasing use of chronic neuromodulation, via deep brain stimulation, for a spectrum of neurological and psychiatric conditions has in tandem led to increased opportunity for linking theories of cognitive processing and neural circuit function. Our purpose here is to motivate the neuroscience and neurosurgical community to capitalize on the opportunities that this next decade will bring. -
The Hypothalamus and Periaqueductal Gray Are the Sources of Dopamine Fibers in the Paraventricular Nucleus of the Thalamus in Th
ORIGINAL RESEARCH ARTICLE published: 20 November 2014 NEUROANATOMY doi: 10.3389/fnana.2014.00136 The hypothalamus and periaqueductal gray are the sources of dopamine fibers in the paraventricular nucleus of the thalamus in the rat Sa Li 1,2, Yuxiu Shi 1* and Gilbert J. Kirouac 2,3 1 PTSD Laboratory, Department of Histology and Embryology, Institute of Pathology and Pathophysiology, China Medical University, Shenyang, China 2 Department of Oral Biology, Faculty of Dentistry, University of Manitoba, Winnipeg, MB, Canada 3 Department of Psychiatry, Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada Edited by: The paraventricular nucleus of the thalamus (PVT) sends a very dense projection to the Kathleen S. Rockland, Boston nucleus accumbens. This area of the striatum plays a key role in motivation and recent University School Medicine, USA experimental evidence indicates that the PVT may have a similar function. It is well known Reviewed by: Ariel Y. Deutch, Vanderbilt that a dopaminergic projection from the ventral tegmental area (VTA) to the nucleus University Medical Center, USA accumbens is a key regulator of motivation and reward-related behavior. Dopamine (DA) Carmen Cavada, Universidad fibers have also been localized in the PVT but the source of these fibers in the rat Autonoma de Madrid, Spain has not been unequivocally identified. The present study was done to re-examine this *Correspondence: question. Small iontophoretic injections of cholera toxin B (CTb) were made in the PVT Yuxiu Shi, PTSD Laboratory, Department of Histology and to retrogradely label tyrosine hydroxylase (TH) neurons. Neurons that were double-labeled Embryology, Institute of Pathology for TH/CTb were found scattered in DA cell groups of the hypothalamus (ventrorostral and Pathophysiology, China Medical A10, A11, A13, A15 DA cell groups) and the midbrain (dorsocaudal A10 embedded in the University, Basic Medical Sciences periaqueductal gray). -
Hypothesis-Driven Structural Connectivity Analysis Supports Network Over Hierarchical Model of Brain Architecture
Hypothesis-driven structural connectivity analysis supports network over hierarchical model of brain architecture Richard H. Thompson and Larry W. Swanson1 Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 Contributed by Larry W. Swanson, June 30, 2010 (sent for review May 14, 2010) The brain is usually described as hierarchically organized, although (9) and a massive input from the SUBv (10). Only two major an alternative network model has been proposed. To help distin- brainstem inputs were identified: the dorsal raphé (DR), the guish between these two fundamentally different structure-function presumptive source of ACBdmt serotonin (11), and the inter- hypotheses, we developed an experimental circuit-tracing strategy fascicular nucleus (IF), the presumptive source of ACBdmt do- that can be applied to any starting point in the nervous system and pamine (12) that is medial to the expected ventral tegmental area then systematically expanded, and applied it to a previously obscure (VTA) itself (13). Thus, the ACBdmt receives direct inputs from dorsomedial corner of the nucleus accumbens identified functionally three massively interconnected cerebral regions implicated in as a “hedonic hot spot.” A highly topographically organized set of stress and depression, as well as restricted brainstem sites pro- connections involving expected and unexpected gray matter regions viding dopaminergic and serotonergic terminals. was identified that prominently features regions associated with Only one ACBdmt axonal output was labeled with PHAL (Fig. appetite, stress, and clinical depression. These connections are 1A; the filled purple area is a representative injection site): a arranged as a longitudinal series of circuits (closed loops). Thus, the descending pathway through the medial forebrain bundle with two results do not support a rigidly hierarchical model of nervous system clear terminal fields. -
Imaging the Centromedian Thalamic Nucleus Using Quantitative Susceptibility Mapping
UC Berkeley UC Berkeley Previously Published Works Title Imaging the Centromedian Thalamic Nucleus Using Quantitative Susceptibility Mapping. Permalink https://escholarship.org/uc/item/7pm0m9bk Authors Li, Jun Li, Yufei Gutierrez, Lorenzo et al. Publication Date 2019 DOI 10.3389/fnhum.2019.00447 Peer reviewed eScholarship.org Powered by the California Digital Library University of California BRIEF RESEARCH REPORT published: 09 January 2020 doi: 10.3389/fnhum.2019.00447 Imaging the Centromedian Thalamic Nucleus Using Quantitative Susceptibility Mapping Jun Li 1†, Yufei Li 2†, Lorenzo Gutierrez 2, Wenying Xu 1, Yiwen Wu 3, Chunlei Liu 4,5, Dianyou Li 1, Bomin Sun 1, Chencheng Zhang 1* and Hongjiang Wei 2* 1Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 3Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Edited by: China, 4Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA, United 5 Adolfo Ramirez-Zamora, States, Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United States University of Florida Health, United States The centromedian (CM) nucleus is an intralaminar thalamic nucleus that is considered as Reviewed by: a potentially effective target of deep brain stimulation (DBS) and ablative surgeries for the Wolf-Julian Neumann, Charité Medical University of Berlin, treatment of multiple neurological and psychiatric disorders. However, the structure of Germany CM is invisible on the standard T1- and T2-weighted (T1w and T2w) magnetic resonance Zhijiang Wang, Peking University Sixth Hospital, images, which hamper it as a direct DBS target for clinical applications. -
A Hierarchical Interpretation of the Functional Organization of the Basal Ganglia
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by PubMed Central HYPOTHESIS AND THEORY ARTICLE published: 11 March 2011 SYSTEMS NEUROSCIENCE doi: 10.3389/fnsys.2011.00013 The arbitration–extension hypothesis: a hierarchical interpretation of the functional organization of the basal ganglia Iman Kamali Sarvestani1,2*, Mikael Lindahl1,2, Jeanette Hellgren-Kotaleski1,2,3 and Örjan Ekeberg1,2 1 Department of Computational Biology, School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden 2 Stockholm Brain Institute, Stockholm, Sweden 3 Department of Neuroscience, Karolinska Institute, Stockholm, Sweden Edited by: Based on known anatomy and physiology, we present a hypothesis where the basal ganglia Federico Bermudez-Rattoni, motor loop is hierarchically organized in two main subsystems: the arbitration system and Universidad Nacional Autónoma de México, Mexico the extension system. The arbitration system, comprised of the subthalamic nucleus, globus Reviewed by: pallidus, and pedunculopontine nucleus, serves the role of selecting one out of several candidate Federico Bermudez-Rattoni, actions as they are ascending from various brain stem motor regions and aggregated in the Universidad Nacional Autónoma de centromedian thalamus or descending from the extension system or from the cerebral cortex. México, Mexico This system is an action-input/action-output system whose winner-take-all mechanism finds Jose Bargas, Universidad Nacional Autónoma de México, Mexico the strongest response among several candidates to execute. This decision is communicated *Correspondence: back to the brain stem by facilitating the desired action via cholinergic/glutamatergic projections Iman Kamali Sarvestani, Department and suppressing conflicting alternatives via GABAergic connections. -
Demarcating the Anatomical Structure of the Claustrum: Piecing Together a New Functional Puddle
bioRxiv preprint doi: https://doi.org/10.1101/179879; this version posted August 23, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-ND 4.0 International license. Demarcating the anatomical structure of the claustrum: piecing together a new functional puddle Christopher M Dillingham1, Bethany E Frost1, Maciej M Jankowski2, Marie AC Lambert3 and Shane M O’Mara1 1Institute of Neuroscience, Trinity College Dublin, College Green, Dublin 2, Ireland 2Hebrew University of Jerusalem, Department of Neurobiology, Jerusalem, Israel 3Université de Poitiers, Faculté des Sciences Fondamentales et Appliquées, Poitiers, France Journal: Brain Structure and Function Corresponding Author Professor Shane O’Mara Room 3.43, Institute of Neuroscience Lloyd Building Trinity College Dublin College Green Dublin 2 Ireland Tel: +353 (01) 896 8447 Email: [email protected] bioRxiv preprint doi: https://doi.org/10.1101/179879; this version posted August 23, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-ND 4.0 International license. Abstract Background: A major obstacle in the understanding of the functional anatomy of the claustrum has been, and continues to be, the contradiction surrounding its anatomical boundary and, in particular, its rostral (i.e. anterior to striatum), extent. In a recent review we highlighted gene expression-based evidence from the mouse brain which lends weight to the idea that the anatomical boundary of the claustrum does in fact extend rostral to the anterior apex of the striatum. -
Understanding the Role of Cholinergic Tone in the Pedunculopontine Tegmental Nucleus
Western University Scholarship@Western Electronic Thesis and Dissertation Repository 7-22-2014 12:00 AM Understanding the role of cholinergic tone in the pedunculopontine tegmental nucleus Kaie Rosborough The University of Western Ontario Supervisor Dr. Vania Prado The University of Western Ontario Graduate Program in Anatomy and Cell Biology A thesis submitted in partial fulfillment of the equirr ements for the degree in Master of Science © Kaie Rosborough 2014 Follow this and additional works at: https://ir.lib.uwo.ca/etd Part of the Behavioral Neurobiology Commons Recommended Citation Rosborough, Kaie, "Understanding the role of cholinergic tone in the pedunculopontine tegmental nucleus" (2014). Electronic Thesis and Dissertation Repository. 2388. https://ir.lib.uwo.ca/etd/2388 This Dissertation/Thesis is brought to you for free and open access by Scholarship@Western. It has been accepted for inclusion in Electronic Thesis and Dissertation Repository by an authorized administrator of Scholarship@Western. For more information, please contact [email protected]. UNDERSTANDING THE ROLE OF CHOLINERGIC TONE IN THE PEDUNCULOPONTINE TEGMENTAL NUCLEUS Thesis format: Monograph Article by Kaie Rosborough Graduate Program in Anatomy and Cell Biology A thesis submitted in partial fulfillment of the requirements for the degree of Masters of Science The School of Graduate and Postdoctoral Studies The University of Western Ontario London, Ontario, Canada © Kaie Rosborough 2014 ! Abstract To better understand the role of cholinergic signaling in specific regions of the brain, several genetically modified mice targeting the vesicular acetylcholine transporter (VAChT) gene have been generated (Prado et al., 2006; Guzman et al., 2011; de Castro et al., 2009). VAChT stores acetylcholine (ACh) in synaptic vesicles, and changes in this transporter expression directly interferes with ACh release. -
Targeting the Centromedian Thalamic Nucleus for Deep Brain Stimulation
medRxiv preprint doi: https://doi.org/10.1101/19008136; this version posted October 18, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . Title: Targeting the centromedian thalamic nucleus for deep brain stimulation Authors: Aaron E.L Warren1,2,3, Linda J. Dalic1,3,4, Wesley Thevathasan4,5,6, Annie Roten1, Kristian J. Bulluss5,7,8, John S. Archer1,2,3,4 1Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Victoria, Australia 2Murdoch Children’s Research Institute, Parkville, Victoria, Australia 3The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia 4Department of Neurology, Austin Health, Heidelberg, Victoria, Australia 5Bionics Institute, East Melbourne, Victoria, Australia 6Department of Medicine, University of Melbourne, and Department of Neurology, The Royal Melbourne Hospital, Parkville, Victoria, Australia 7Department of Neurosurgery, Austin Health, Heidelberg, Victoria, Australia 8Department of Surgery, University of Melbourne, Parkville, Victoria, Australia Corresponding author: Aaron E.L. Warren Ph: +613 9035 7110 Email: [email protected] Address: Melbourne Brain Centre, 245 Burgundy Street, Heidelberg, VIC, Australia 3084 Key words: Deep brain stimulation, centromedian nucleus, thalamus, epilepsy, Lennox- Gastaut syndrome, microelectrode recording, fMRI 1 NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice. medRxiv preprint doi: https://doi.org/10.1101/19008136; this version posted October 18, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.