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NOBEL MOLECULAR Frontiers NOBEL WORKSHOP & MOLECULAR FRONTIERS SYMPOSIUM Nobel Workshop & Molecular Frontiers Symposium organized by: An Amazing Week at Chalmers May 4th-8th 2015 RunAn Conference Hall, Chalmers University of Technology Chalmersplatsen 1, Gothenburg, Sweden !"#$%&'(") )*!%)!") Welcome!( The!Nobel!Workshop!and!Molecular!Frontiers!Symposium!in!Gothenburg!are!spanning!over! widely!distant!horizons!of!the!molecular!paradigm.!From!addressing!intriguing!questions!of! life! itself,! how! it! once! began! and! how! molecules! like! cogwheels! work! together! in! the! complex! machinery! of! the! cell! E! to! various! practical! applications! of! molecules! in! novel! materials!and!in!energy!research;!from!how!biology!is!exploiting!its!molecules!for!driving!the! various! processes! of! life,! to! how! insight! into! the! fundamentals! of! photophysics! and! photochemistry!of!molecules!may!give!us!clues!about!solar!energy!and!tools!by!which!we! may!tame!it!for!the!benefit!of!all!of!us,!and!our!environment.!! ! ! Science!is!sometimes!artificially!divided!into!“fundamental”!and!”applied”!but!these! terms!are!irrelevant!because!research!is!judged!to!be!groundbreaking!by!the!consequences! it!may!have.!Any!groundbreaking!fundamental!result!has!sooner!or!later!consequences!in! applications,!and!the!limits!are!often!only!drawn!by!our!imagination.!! ! ! Science!is!very!much!a!matter!of!communication:!we!not!only!learn!from!each!other! (facts,!ideas!and!concepts),!we!also!need!interactions!for!inspiration!and!as!testing!ground! for!our!ideas.!A!successful!scientific!communication!(publication!or!lecture)!always!requires! a!pedagogically!delivered!message.!That!an!author!understands!what!he/she!is!doing!is!not! a! guarantee! for! explaining! well! (although! it! often! helps!).! The! Molecular! Frontiers! Symposium,!for!highEschool!pupils,!presents!a!special!challenge!to!the!speakers!for!making! themselves! understood.! However,! I! would! say! the! difference! is! not! that! big! between! speaking! to! your! peers! or! to! less! scientifically! trained! mind.! Common! to! all! scientific! questions! is! that! they! need! to! be! broken! down! into! logical! elements:! a! hypothesis! is! generally!tested!by!a!chain!of!arguments!and!the!total!strength!of!the!chain!is!always!limited! by!its!weakest!link.!While!an!experienced!scientist!is!sometimes!blind!to!where!the!weak! links!are,!a!young!and!unbiased!mind!sometimes!asks!the!really!good!questions.!This!is!an! ability! that! we! will! recognize! by! The! Inquiry! Prize! –! a! unique! worldEwide! competition! created!by!the!Molecular!Frontiers!Foundation,!where!the!prize!is!given!for!asking!a!really! good!question,!not!for!knowing!the!answer.!The!Inquiry!Prize!Jury!is!composed!of!members! of!the!Scientific!Advisory!Board!of!the!Molecular!Frontiers!Foundation!and!they!will!award! the!prizes!to!5!girls!and!5!boys.!!! ! ! A!hallmark!of!this!Amazing!Week!is!diversity:!we!shall!enjoy!the!lectures,!ideas!and! company!of!front!figures!from!a!range!of!different!fields.!Diversity!is!a!challenge,!but!the! molecules-and-frontiers-in-molecular-sciences!are!the!common!denominator!of!this!week.! This!is!a!great!opportunity!to!get!exposed!to!new!facts!and!new!ideas!and!be!inspired!!! ! It!is!my!hope!that!all!of!you,!young!as!well!as!less!young,!will!enjoy!the!exciting!days!during! this!week,!and!get!inspired!E!maybe!so!much!so!that!you!will!also!decide!to!devote!yourself! to!science.! ! Bengt!Nordén! Professor,of,Physical,Chemistry,at,Chalmers,University,of,Technology, Founding,Chairman,of,the,Molecular,Frontiers,Foundation, ! 3! , ! 4! ! Nobel!Workshop!! DAY!1! Organized!by!The!Royal)Swedish)Academy)of)Sciences!! and!the!Chalmers!Life)Science)Engineering!Area!of!Advance!! ! Date:!! !!!!!!!!!!!!!!Monday!May!4th,!2015! Topic:!!! MOLECULES!IN!LIFE!SCIENCE!RESEARCH! !! Chairs:!!! Prof.!Jens!Nielsen!and!Prof.!Andrew!Ewing! Venue:!!! RunAn!Conference!Hall,!Chalmers!University!of!Technology,!! Chalmersplatsen!1,!SEL412!58!Göteborg,!Sweden! ! 08:35L08:40! Welcome)note:"Prof"Karin"Markides,"Chalmers"President! 08:40L08:45! Opening)note:"Prof"Jens"Nielsen,"Director"of"Life"Science"Engineering"! 08:45L09:25! Prof!DAVID!LILLEY,!University!of!Dundee,!United!Kingdom! How"does"RNA"act"like"an"enzyme! 09:25L10:05! Prof!PETER!von!HIPPEL,!University!of!Oregon,!United!States! Mapping"structural"and"dynamic"interactions"of"regulatory"proteins"with"DNA"at"single" nucleotide"resolution! 10.05L10:35! Coffee)break! 10:35L11:15! Nobel!Laureate!ADA!YONATH,!Weizmann!Institute!of!Science,!Israel! SpeciesFspecific"antibiotics"and"the"microbiome" 11:15L11:55!! Prof!YAHLI!LORCH,!Stanford!University,!United!States! Chromatin"remodeling! 11:55L12:55! Lunch)break! 12:55L13:35! Nobel!Laureate!ARIEH!WARSHEL,!University!of!Southern!California,!United!States!Evaluating" and"using"free"energy"landscapes"for"biological"functions!! 13:35L14:15! Nobel!Laureate!MICHAEL!LEVITT,!Stanford!University,!United!States! Solving"Large"&"Difficult"Structures"with"Less"Experimental"Data!! 14:15L14:55! Prof.!DINA!PETRANOVIC,!Chalmers!University!of!Technology,!Sweden!! Yeast"as"a"model"for"human"diseases! 14:55L15:25! Coffee)break) 15:25L16:05!!! Prof!RICHARD!LERNER,!The!Scripps!Research!Institute,!United!States!! Selecting"Antibodies"from"Combinatorial"Libraries"for"the"Treatment"of"Cancer!! 16:05L16:45! Prof!ANDREW!McCAMMON,!University!of!California,!San!Diego,!United!States!Molecular" Dynamics"and"Drug"discovery! 16:45L18:00! Panel)discussion:)Opportunities)and)Challenges)in)Life)Science)Research!! (Moderators:!Jens!Nielsen!and!Andrew!Ewing)! ! 5! !! ! Nobel!Workshop!! DAY!2! Organized!by!The)Royal)Swedish)Academy)of)Sciences!! and!the!Chalmers!Energy)and)Nanoscience)and)Nanotechnology!Areas!of!Advance!! ! Date:! !!!!!!!!!!!!!!Tuesday!May!5th,!2015! Topic:!! MOLECULES!IN!NANO!AND!ENERGY!RESEARCH! !! Chairs:!! Prof.!Bo!Albinsson!and!Dr.!Anders!Ådahl! Venue:!!! RunAn!Conference!Hall,!Chalmers!University!of!Technology,!! Chalmersplatsen!1,!SEL412!58!Göteborg,!Sweden! ! 08:25L08:30! Opening)note:"Prof"Bo"Albinsson,"Director"of"Nanoscience"and"Nanotechnology"and"Dr." Anders"Ådahl,"Director"of"Energy"! 08:30L09:10! Prof!HARRY!GRAY,!California!Institute!of!Technology,!United!States:!The"Currents"of"Life:" Electron"Flow"through"Proteins" 09:10L09:50! Nobel!Laureate!ROGER!KORNBERG,!Stanford!University,!United!States! Metal"nanoparticles:""atomic"structures"and"applications"in"cryoFelectron"microscopy! 09:50L10:20! Coffee)break! 10:20L11.00! Prof!REIKO!KURODA,!University!of!Tokyo,!Japan! A"twisting"story:"how"a"single"gene"twists"a"snail! 11:00L11:40! Prof!WAYNE!HENDRICKSON,!Columbia!University,!United!States! Distinctions"and"Shared"Principles"in"Transmembrane"Ion"Channels"" 11:40L12:20! Nobel!Laureate!KURT!WÜTHRICH,!The!!Scripps!!Research!!Institute,!!United!States!!!! Sunset"of"the"NIH"Protein"Structure"Initiative"–"What"Next?" 12:20L13:20! Lunch)break! 13:20L14:00! Nobel!Laureate!JEANSMARIE!LEHN,!University!of!Strasbourg,!France! Towards"adaptive"chemistry! 14:00L14:40! Nobel!Laureate!BARRY!SHARPLESS,!The!Scripps!Research!Institute,!United!States!Exploring" the"Sulfate"World" 14:40L15:10! Coffee)break)! 15:10L15:50! Prof!JOSEF!MICHL,!University!of!Colorado!at!Boulder,!United!States,!and!Institute!of!Organic! Chemistry!and!Biochemistry!ASCR,!Prague,!Czech!Republic! Unconventional"solar"energy"–"singlet"fission! 15:50L16:30! Prof!Sir!JOHN!MEURIG!THOMAS,!University!of!Cambridge,!United!Kingdom! Tomorrow's"Catalysts:"Actual"and"Desired! 16:30L18:00!! Panel)discussion:)Opportunities)and)Challenges)in)Nanotechnology)and)Energy!Research) (Moderators:!Bo!Albinsson!and!Anders!Ådahl)! ! ! 6! ! Nobel!Workshop!! DAY!3! Organized!by!The)Royal)Swedish)Academy)of)Sciences!! and!the!Chalmers!Materials)Sciences!Area!of!Advance!! ! Date:! !!!!!!!!!!!!!!Wednesday!May!6th,!2015! Topic:!! MOLECULES!IN!MATERIALS!RESEARCH! Chairs:!!! Prof.!Aleksandar!Matic!and!Prof.!Fredrik!Höök! Venue:!!! RunAn!Conference!Hall,!Chalmers!University!of!Technology,!! Chalmersplatsen!1,!SEL412!58!Göteborg,!Sweden! ! 08:25L08:30! Opening)note:"Prof"Aleksandar"Matic,"Director"Materials"Science"! 08:30L09:10! Nobel!Laureate!STEFAN!HELL,!University!of!Göttingen,!Germany! Nanoscopy"with"focused"light! 09:10L09:50! Nobel!Laureate!WILLIAM!MOERNER,!Stanford!University,!United!States! Single"molecule"spectroscopy! 09:50L10:20! Coffee)break! 10:20L11:00! Prof!ROBERT!LANGER,!Massachusetts!Institute!of!Technology,!United!States!! Advances"in"biomaterials"and"drug"delivery! 11:00L11:40! Prof!TOM!BROWN,!University!of!Oxford,!United!Kingdom! Chemical"synthesis"of"DNA"–"RealFworld"applications! 11:40L12:20! Nobel!Laureate!ANDREW!FIRE,!Stanford!University,!United!States! Taming"opportunistic"RNAs! 12:20L13:20! Lunch)break)! 13:20L14:00! Prof!JAMES!BARBER,!Imperial!College!London,!United!Kingdom! From"natural"to"artificial"photosynthesis"for"renewable"fuels! 14:00L14:40! Prof!PAUL!ALIVISATOS,!University!of!California!Berkeley,!United!States! Nanoscience"and"the"Future"of"the"Carbon"Cycle! 14:40L15:20!!! Prof!TOSHIO!YANAGIDA,!Osaka!University,!Japan! Role"of"fluctuations"for"driving"bioFmolecular"machines"! 15:20L15:50! Coffee)break! 15:50L16:30! Dr!RICHARD!HENDERSON,!MRC!LMB,!Cambridge,!United!Kingdom! ! Structure"of"membrane"proteins"involved"in"signal"transduction" 16:30L18:00! Panel)discussion:)Opportunities)and)Challenges)in)Materials!Research)) (Moderators:!Aleksandar!Matic!and!Fredrik!Höök)!! ! ! ! ! ! 7! ! ! Molecular!Frontiers!Symposium!! DAY!1! Organized!by!The!Royal)Swedish)Academy)of)Sciences!! and!Molecular)Frontiers)Foundation!
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