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Guidance for the Format and Content of the Protocol of Non-Interventional
PASS information Title Metformin use in renal impairment Protocol version identifier Version 2 Date of last version of 30 October 2013 protocol EU PAS register number Study not registered Active substance A10BA02 metformin Medicinal product Metformin Product reference N/A Procedure number N/A Marketing authorisation 1A Farma, Actavis, Aurobindo, Biochemie, Bluefish, holder(s) Hexal, Mylan, Orifarm, Pfizer, Sandoz, Stada, Teva Joint PASS No Research question and To assess the use and safety of metformin in patients objectives with and without renal insufficiency in current clinical practice in at least two EU Member States. Country(-ies) of study Denmark, United Kingdom Author Christian Fynbo Christiansen, MD, PhD Page 1/214 Marketing authorisation holder(s) Marketing authorisation N/A holder(s) MAH contact person N/A Page 2/214 1. Table of Contents PASS information .......................................................................................................... 1 Marketing authorisation holder(s) .................................................................................... 2 1. Table of Contents ...................................................................................................... 3 2. List of abbreviations ................................................................................................... 4 3. Responsible parties .................................................................................................... 5 4. Abstract .................................................................................................................. -
Tests Spring 2012
Tests spring 2013 Test 1 Oral cavity 1. Vestibulum oris does not communicate with proper oral cavity through: :r1 oral part of pharynx :r2 tremata :r3 space behind last molar :r4 space when tooth is missing :r5 communicates through all mentioned ways -- 2. Into vestibule of oral cavity opens out: :r1 caruncula sublingualis :r2 papilla parotidea :r3 ductus nasolacrimalis :r4 plica sublingualis :r5 none of mentioned answers is correct -- 3. The underlay of lips is: :r1 m. labialis :r2 m. orbicularis oculi :r3 m. orbicularis oris :r4 m. buccalis :r5 none of mentioned answers is correct -- 4. The upper lip is partially connected with alveolar process using: :r1 lig. labii superioris :r2 m. platysma :r3 frenulum labii superioris :r4 plica labii superioris :r5 none of mentioned answers is correct -- 5. Cheek is not made up of: :r1 skin :r2 adipose body :r3 muscular layer :r4 adventitia :r5 none of mentioned answers is correct -- 6. Parotid duct passes through: :r1 m. masseter :r2 m. buccinator :r3 m. orbicularis oris :r4 m. pterygoideus lateralis :r5 none of mentioned answers is correct -- 7. The underlay of hard palate is not: :r1 praemaxilla :r2 vomer :r3 processus palatinus maxillae :r4 lamina horizontalis ossis palatini :r5 all mentioned bones form the underlay of hard palate -- 8. Which statement describing mucosa of hard palate is not correct: :r1 it contains big amount of submucosal connective tissue :r2 it is covered by columnar epithelium :r3 firmly grows together with periosteum :r4 it is almost not movable against the bottom :r5 it contains glandulae palatinae -- 9. Mark the true statement describing the palate: :r1 there is papilla incisiva positioned there :r2 mucosa contains glandulae palatinae :r3 there are plicae palatinae transversae positioned there :r4 the basis of soft palate is made by fibrous aponeurosis palatina :r5 all mentioned statements are correct -- 10. -
Fig. 2-32 Facial Muscles. Fig. 2-33 Trigeminal Nerve (CN V)
Fig. 2-32 Facial Muscles. Fig. 2-33 Trigeminal Nerve (CN V) leaving the Skull. 51 thetic agent at the infraorbital foramen or in the infraor- posterior to its head and anterior to the auricle. It then bital canal (e.g., for treatment of wounds of the upper crosses over the root of the zygomatic process of the lip and cheek or for repairing the maxillary incisor teeth). temporal bone, deep to the superficial temporal artery. The site of emergence of this nerve can easily be deter- As its name suggests, it supplies parts of the auricle, mined by exerting pressure on the maxilla in the region external acoustic meatus, tympanic membrane (ear- of the infraorbital foramen and nerve. Pressure on the drum), and skin in the temporal region. The inferior al- nerve causes considerable pain. Care is exercised when veolar nerve is the large terminal branch of the posterior performing an infraorbital nerve block because compan- division of CN V3; the lingual nerve is the other terminal ion infraorbital vessels leave the infraorbital foramen with branch. It enters the mandibular canal through the man- the nerve. Careful aspiration of the syringe during injec- dibular foramen. In the canal it gives off branches that tion prevents inadvertent injection of the anesthetic fluid supply the mandibular (lower) teeth. Opposite the mental into a blood vessel. The orbit is located just superior to foramen, the inferior alveolar nerve divides into its ter- the injection site. A careless injection could result in minal incisive and mental branches. The incisive nerve the passage of anesthetic fluid into the orbit, causing supplies the incisor teeth, the adjacent gingiva, and temporary paralysis of the extraocular muscles. -
Incidence, Morbidity and Mortality of Patients with Achalasia in England: Findings from a Nationwide Hospital Database and 4 Million Population Based Data
Incidence, morbidity and mortality of patients with achalasia in England: findings from a nationwide hospital database and 4 million population based data Appendix A: International Classification of Disease codes for Achalasia (HES) K22 – Achalasia of cardia Appendix B: Read codes (The Health Improvement Network) Appendix B1: Achalasia codes Clinical code Description J100.00 Achalasia of cardia Appendix B2: Clinical codes used to identify Hypertension, Diabetes and lipid lowering drugs Diabetes Clinical code Description C10..00 Diabetes mellitus C100.00 Diabetes mellitus with no mention of complication C100000 Diabetes mellitus, juvenile type, no mention of complication C100011 Insulin dependent diabetes mellitus C100100 Diabetes mellitus, adult onset, no mention of complication C100111 Maturity onset diabetes C100112 Non-insulin dependent diabetes mellitus C100z00 Diabetes mellitus NOS with no mention of complication C101.00 Diabetes mellitus with ketoacidosis C101000 Diabetes mellitus, juvenile type, with ketoacidosis C101100 Diabetes mellitus, adult onset, with ketoacidosis C101y00 Other specified diabetes mellitus with ketoacidosis C101z00 Diabetes mellitus NOS with ketoacidosis C102.00 Diabetes mellitus with hyperosmolar coma C102000 Diabetes mellitus, juvenile type, with hyperosmolar coma C102100 Diabetes mellitus, adult onset, with hyperosmolar coma C102z00 Diabetes mellitus NOS with hyperosmolar coma C103.00 Diabetes mellitus with ketoacidotic coma C103000 Diabetes mellitus, juvenile type, with ketoacidotic coma C103100 Diabetes -
Anatomy of the Woodchuck (Marmota Monax)
QL737 .R68B49 2005 Anatomy of the Woodchuck (Marmota monax) A. J. Bezuidenhout and H. E. Evans SPECIAL PUBLICATION NO. 13 AMERICAN SOCIETY OF MAMMALOGISTS LIBRARY OF THE /XT FOR THE ^> ^ PEOPLE ^ ^* <£ FOR _ EDVCATION O <£ FOR ^J O, SCIENCE j< Anatomy of the Woodchuck (Marmota monax) by A. J. Bezuidenhout and H. E. Evans SPECIAL PUBLICATION NO. 13 American Society of Mammalogists Published 21 February 2005 Price $45.00 includes postage and handling. American Society of Mammalogists P.O. Box 7060 Lawrence, KS 66044-1897 ISBN: 1-891276-43-3 Library of Congress Control Number: 2005921107 Printed at Allen Press, Inc., Lawrence, Kansas 66044 Issued: 21 February 2005 Copyright © by the American Society of Mammalogists 2005 SPECIAL PUBLICATIONS American Society of Mammalogists This series, published by the American Society of Mammalogists in association with Allen Press, Inc., has been established for peer-reviewed papers of monographic scope concerned with any aspect of the biology of mammals. Copies of Special Publications by the Society may be ordered from: American Society of Mammalogists, % Allen Marketing and Management, P.O. Box 7060, Lawrence, KS 66044-8897, or at www. mammalogy.org. Dr. Joseph F. Merritt Editor for Special Publications Department of Biology United States Air Force Academy 2355 Faculty Drive US Air Force Academy, CO 80840 Dr. David M. Leslie, Jr. Chair, ASM Publications Committee Oklahoma Cooperative Fish and Wildlife Research Unit United States Geological Survey 404 Life Sciences West Oklahoma State University Stillwater, OK 74078-3051 Anatomy of the Woodchuck (Marmota MONAX) A. J. Bezuidenhout and H. E. Evans Published by the American Society of Mammalogists Contents Page Acknowledgments vii Foreword ix Chapter 1. -
The Boundaries of the Region Are Margo Supraorbitalis, Linea Temporalis Superior, Linea Nuchae Superior Till Protuberantia Occipitalis Externa
Topographical anatomy & operative surgery of the head. Topographical pecularities of regions of the head and its practical importance. Main principles of surgical treatments The boundaries and divisions. The border between the head and a neck carried out (conditionally) to the inferior margin of mandible, angle of mandible, posterior margin of the vertical process of the mandible; the anterior and posterior edges of the mastoid process, superior nuchal line (linea nuchae superior), external occipital protuberance (protuberantia occipitalis externa). Then it passes symmetrically to the opposite side. On the head distinguish cerebral and facial departments, according to the cerebral and facial skull. The border between these departments passes by supraorbital margin, superior margin of the zygomatic arch to the porus acusticus externus. All that is down and anterior to this border belongs to the facial department, which is upward and backward, refers to the cerebral department. The cerebral department is divided into calvaria (fornix cranii) and bases of skull (basis cranii). The boundary between the base of scull and calvaria is mainly passes by the horizontal plane which joins the nasion to the inion (an imaginary line that passes along the supraorbital margin - margo supraorbitalis, superior margin of the zygomatic arch - arcus zigomaticus, base of the mastoid process - processus mastoideus, upper nuchal line - linea nuchae superior to inion). The parts of the skull located above this plane belong to the calvaria; located below - to the base of skull. Calvaria areas. 1) fronto-parietal-occipital region - regio frontoparietooccipitalis; 2) Temporal region - regio temporalis. Fronto-parieto-occipital region (regio fronto-parieto-occipitalis) The boundaries of the region are margo supraorbitalis, linea temporalis superior, linea nuchae superior till protuberantia occipitalis externa. -
Supplemental Data
Appendix Table 1. Read codes for nephrolithiasis on or after index date Read code Description Count K120.12 Renal calculus 3996 7B0B.00 Extracorporeal shockwave lithotripsy for renal calculus 2765 K120.13 Renal stone 1662 K121.12 Ureteric stone 1046 7B07.12 Percutaneous lithotripsy of renal calculus 977 C341111 Renal stone - uric acid 963 7B18.00 Ureteroscopic operations for ureteric calculus 718 7B1C.00 Extracorporeal shockwave lithotripsy of ureteric calculus 637 K121.11 Ureteric calculus 589 4G4..11 O/E: kidney stone 572 K120.00 Calculus of kidney 504 7B07.13 PCNL - Percutaneous nephrolithotomy 408 K12..00 Calculus of kidney and ureter 273 7B07.00 Percutaneous renal stone surgery 259 4G4..00 O/E: renal calculus 224 K120z00 Renal calculus NOS 214 7B18000 Ureteroscopic laser lithotripsy of ureteric calculus 184 K120.11 Nephrolithiasis NOS 173 7B18200 Ureteroscopic extraction of ureteric calculus 162 K121.00 Calculus of ureter 161 7B19000 Cystoscopic laser lithotripsy of ureteric calculus 136 7B17111 Other nephroscopic lithotripsy of ureteric calculus 103 7B0C200 Percutaneous nephrolithotomy NEC 100 7B0B000 ESWL for renal calculus of unspecified size 95 K12z.00 Urinary calculus NOS 88 4G6..00 O/E - ureteric calculus 88 7B18100 Other ureteroscopic fragmentation of ureteric calculus 82 7B05800 Simple nephrolithotomy 72 7B17000 Nephroscopic laser lithotripsy of ureteric calculus 67 7B18011 Ureteroscopic laser fragmentation of ureteric calculus 60 7B0Bz00 Extracorporeal shockwave lithotripsy for renal calculus NOS 57 7B0B.11 Extracorporeal -
MRCS in Capsule
Upper Limb MRCS in Capsule Dr. Ahmed Elsabbagh A. Muscles of pectoral region Pectoralis major Pectoralis minor Serratus anterior Origin Clavicular head: Front of medial Outer surface of 3rd, 4th & - By 8 digitations from outer ½ of the clavicle. 5th ribs near costal surface of upper 8 ribs. cartilages. Sternocostal head: From: 1- Front of sternum. 2- Upper 6 costal cartilages. Insertion In lateral lip of the bicipital Coracoid process of the The muscle is inserted into ventral groove. scapula. surface of the medial border of scapula, Nerve supply Medial and lateral pectoral Medial pectoral nerve Long thoracic nerve (of Belly) nerves. Action 1. Clavicular head: Fixing scapula to posterior thoracic wall Flexion of arm. so its paralysis leads to winging of 2. Whole muscle: scapula. adduction & medial rotation of arm pectoralis minor Serratus anterior Clavi-pectoral fascia Def: strong fibrous membrane of deep fascia filling the gap between pectoralis minor & the clavicle Site: Deep to pectoralis major Attachments: • Above: it splits to enclose subclavius muscle then it attaches to lower surface of the clavicle • Below: it splits to enclose pectoralis minor muscle then continue downward to be attached to axillary fascia forming (suspensory ligament of axilla). • Medially: 1st costal cartilage • Laterally: coracoid process & clavicle CLAF Structures piercing it: • Cephalic vein • Lateral pectoral nerve • Acromiothoracic artery • Fat, LNS Trapezius Latissimus dorsi Origin - Spine of c7 - Lower 6 thoracic spines & all lumber - All thoracic spines & supra vertebrae with their supraspinous spinous ligaments ligaments Insertion Clavicle & scapula Floor of the bicipital groove NS spinal accessory nerve N. to latissimus dorsi (thoraco-dorsal nerve ) Action It rotates the scapula upward Adduction, extension and medial rotation of 90 – 180 shoulder joint Flexor Muscles of forearm NB: common flexor origin (CFO) presents infront of medial epicondyle of humerus. -
READ Codes of Conditions Affecting Venous Thromboembolism
Web appendix 2: READ codes of conditions affecting venous thromboembolism READ code READ description Variable group B670.00 Acute erythraemia and erythroleukaemia cancer B680.00 Acute leukaemia NOS cancer B640.00 Acute lymphoid leukaemia cancer B660.00 Acute monocytic leukaemia cancer B675.00 Acute myelofibrosis cancer B650.00 Acute myeloid leukaemia cancer B690.00 Acute myelomonocytic leukaemia cancer B674.00 Acute panmyelosis cancer B65y100 Acute promyelocytic leukaemia cancer B64y200 Adult T-cell leukaemia cancer B142.11 Anal carcinoma cancer B602.00 Burkitt's lymphoma cancer B602z00 Burkitt's lymphoma NOS cancer B602300 Burkitt's lymphoma of intra-abdominal lymph nodes cancer B602200 Burkitt's lymphoma of intrathoracic lymph nodes cancer B602100 Burkitt's lymphoma of lymph nodes of head, face and neck cancer B602500 Burkitt's lymphoma of lymph nodes of inguinal region and leg cancer B34..11 Ca female breast cancer B1z0.11 Cancer of bowel cancer B440.11 Cancer of ovary cancer B161211 Carcinoma common bile duct cancer B160.11 Carcinoma gallbladder cancer B3...11 Carcinoma of bone, connective tissue, skin and breast cancer B134.11 Carcinoma of caecum cancer B1...11 Carcinoma of digestive organs and peritoneum cancer B4...11 Carcinoma of genitourinary organ cancer B00..11 Carcinoma of lip cancer B0...11 Carcinoma of lip, oral cavity and pharynx cancer B5...11 Carcinoma of other and unspecified sites cancer B141.11 Carcinoma of rectum cancer B2...11 Carcinoma of respiratory tract and intrathoracic organs cancer B590.11 Carcinomatosis cancer -
The Face – Yukiya Oba2 Scott Lozanoff3 a Vascular Perspective
382 RESEARCH AND SCIENCE Thomas von Arx1 Kaori Tamura2 The Face – Yukiya Oba2 Scott Lozanoff3 A Vascular Perspective 1 Department of Oral Surgery and Stomatology, School of Dental Medicine, University A literature review of Bern, Bern, Switzerland 2 Department of Kinesiology and Rehabilitation Science, University of Hawai’i, Hono lulu, USA KEYWORDS 3 Department of Anatomy, Anatomy Biochemistry and Physiology, Face John A. Burns School of Medi Vascular supply cine, University of Hawai’i, Arteries Honolulu, USA Veins Lymphatics CORRESPONDENCE External/internal carotid arteries Prof. Dr. Thomas von Arx Klinik für Oralchirurgie und Stomatologie Zahnmedizinische Kliniken der Universität Bern SUMMARY Freiburgstrasse 7 Vascular supply is key for maintenance of healthy systems. Main arterial contributors to the face CH3010 Bern Tel. +41 31 632 25 66 tissue conditions but also with regard to healing include the facial, transverse facial, and infra Fax +41 31 632 25 03 following trauma or therapeutic interventions. orbital arteries. In general, homonymous veins Email: thomas.vonarx@ The face is probably the most exposed part of the accompany the arteries, but there are some zmk.unibe.ch body and any changes of vascularity are readily exceptions (inferior ophthalmic vein, retro SWISS DENTAL JOURNAL SSO 128: visible (skin blanching, ecchymosis, hematoma, mandibular vein). Furthermore, the facial vein 382–392 (2018) edema). With regard to the arterial supply, all demonstrates a consistently more posterior Accepted for publication: vessels reaching the facial skin originate from the course compared to the facial artery. Lymphatic 12 September 2017 bilateral common carotid arteries. The ophthal vessels including lymph nodes play an important mic artery is considered the major arterial shunt role for facial drainage. -
Courses of Lectures of Inflammatory Diseases, Localized in the Maxilla-Facial Region
Natalia Rusu Courses of lectures of inflammatory diseases, localized in the maxilla-facial region Chisinau, 2012 1 Introduction In the present study guide for maxilla-facial surgery and dental surgery, briefly, are described some facial and neck diseases namely etiology, pathogenesis, diagnostics, of the clinical progression and treatment of the given diseased peculiarities. Collection of lecture material about inflammatory processes localized in the maxilla-facial region will help students and physician residents of dental departments in the given speciality study. The present manual is composed in accordance with syllabus approved for students and physician-residents of dental department, of the State University of Medicine and Pharmacy “Nicolae Testemitanu” of Republic Of Moldova. The manual contains the lecture material for students of 3rd year of stomatological department. Rusu Natalia Valentin - Doctor of Medical Science, the Head of the Educational Unit of the maxilla-facial surgery department “Gutan Arsenii”, State University of Medicine and Pharmacy “Nicolae Testemitanu” of Republic Of Moldova. 2 I Chapter Topic № 1 Inflammatory processes in maxillofacial region Ethiology and pathogenesis of odontogenic inflammatory diseases Inflammatory diseases of maxillofacilal area inherently are infectious inflammatory processes, (that is)i.e are caused by microbes the majority of which under ordinary conditions which perennate on skin integument and oral mucosa. During the skin integument disintegration and mucous coat, affect of acentric paradontium and also the hard tooth tissues degradation with its opening of pulp cavity, these microbes invade in subjacent tissues. Depending on localization of site of entry for microbes can be distinguished odontogenic, stomatogenic, tonsillogenic, rinogenic and dermatogenic infectious inflammatory processes. -
For Peer Review Only Journal: BMJ Open
BMJ Open BMJ Open: first published as 10.1136/bmjopen-2014-006604 on 14 November 2014. Downloaded from Exposure to sodium channel-inhibiting drugs and cancer survival: protocol for a cohort study using the QResearch primary care database For peer review only Journal: BMJ Open Manuscript ID: bmjopen-2014-006604 Article Type: Protocol Date Submitted by the Author: 11-Sep-2014 Complete List of Authors: Fairhurst, Caroline; University of York, Health Sciences Watt, Ian; University of York, Health Sciences Martin, Fabiola; Hull York Medical School, Bland, Martin; University of York, Health Sciences Brackenbury, William; University of York, Biology <b>Primary Subject Oncology Heading</b>: Secondary Subject Heading: Epidemiology, Pharmacology and therapeutics PRIMARY CARE, Epilepsy < NEUROLOGY, Breast tumours < ONCOLOGY, Keywords: Epidemiology < ONCOLOGY, STATISTICS & RESEARCH METHODS, Clinical trials < THERAPEUTICS http://bmjopen.bmj.com/ on September 29, 2021 by guest. Protected copyright. For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 1 of 36 BMJ Open BMJ Open: first published as 10.1136/bmjopen-2014-006604 on 14 November 2014. Downloaded from 1 2 3 Exposure to sodium channel-inhibiting drugs and cancer survival: 4 5 protocol for a cohort study using the QResearch primary care database 6 7 8 9 Caroline Fairhurst1, Ian Watt1,2, Fabiola Martin2,3, Martin Bland1, and William 10 11 J. Brackenbury3* 12 13 1Department of Health Sciences, University of York, York, UK 14 15 2HullFor York Medical peer School, York, review UK only 16 17 3Department of Biology, University of York, York, UK 18 19 20 21 *Corresponding author: 22 23 William J.