IB Recombinant Cat. No.: 92-607

Activin Receptor IB Recombinant Protein

Specifications

SPECIES: Mouse

SOURCE SPECIES: Human Cells

SEQUENCE: Leu32-Glu126

FUSION TAG: C-Fc tag

TESTED APPLICATIONS:

APPLICATIONS: This recombinant protein can be used for biological assays. For research use only.

PREDICTED MOLECULAR 37.7 kD WEIGHT:

Properties

Greater than 95% as determined by reducing SDS-PAGE. PURITY: Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

PHYSICAL STATE: Lyophilized

Lyophilized from a 0.2 um filtered solution of PBS,pH7.4. It is not recommended to BUFFER: reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

October 1, 2021 1 https://www.prosci-inc.com/activin-receptor-ib-recombinant-protein-92-607.html Lyophilized protein should be stored at -20˚C, though stable at room temperature for 3 weeks. STORAGE CONDITIONS: Reconstituted protein solution can be stored at 4-7˚C for 2-7 days. Aliquots of reconstituted samples are stable at -20˚C for 3 months.

Additional Info

OFFICIAL SYMBOL: Acvr1b

Activin Receptor Type-1B, Activin Receptor Type IB, ACTR-IB, Activin Receptor-Like ALTERNATE NAMES: 4, ALK-4, Serine/Threonine-Protein Kinase Receptor R2, SKR2, ACVR1B, ACVRLK4, ALK4, Activin RIB

ACCESSION NO.: Q61271

GENE ID: 11479

Background and References

Activin Receptor Type-1B (ACVR1B) is a single-pass type I membrane protein that belongs to the protein kinase superfamily. ACVR1B contains one GS domain and one and is expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. ACVR1B acts as a transducer of activin or activin like ligands signals. Activin BACKGROUND: binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B, ACVR2A or ACVR2B activating ACVR1B through phosphorylation of its regulatory GS domain. They go on to recruit the R-SMADs, SMAD2 and SMAD3. ACVR1B also transducers signals of , GDF-1, and Vg1. Mutations in ACVR1B are associated with pituitary tumors.

ANTIBODIES FOR RESEARCH USE ONLY.

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October 1, 2021 2 https://www.prosci-inc.com/activin-receptor-ib-recombinant-protein-92-607.html