BREAKING THROUGH 2014 Annual Report OUR MISSION: FROM CRI’S SAVE MORE LIVES WITH CANCER IMMUNOTHERAPY LEADERSHIP Established in 1953, the Cancer Research Institute (CRI) is the world’s only nonprofit his past year was one of many breakthroughs for the ever have at one time before. We launched a new patient organization dedicated exclusively to saving TCancer Research Institute (CRI). Science magazine website, TheAnswerToCancer.org, designed to educate cancer patients’ lives by fueling the development named cancer immunotherapy the “Breakthrough patients and caregivers about cancer immunotherapy. We of smarter, more effective treatments that of the Year,” catapulting the work that CRI does celebrated our second annual Cancer Immunotherapy mobilize our immune defenses against all forms into the spotlight. It was also the year that several Month, mobilizing individuals and companies across of cancer. CRI supports the most innovative immunotherapies pioneered by CRI scientists received the world to participate in our education and awareness research of young scientists, invests in clinical “Breakthrough Therapy” status from the FDA, paving the activities. And our Clinical Accelerator program is studies of encouraging new treatments, and way for important new drug approvals. In September of spearheading several important clinical trials that are unites the efforts of the field’s leaders worldwide. 2014, U.S. regulators approved Merck’s drug Keytruda® bringing lifesaving immunotherapies to patients faster. With this work, CRI is turning our own immune (pembrolizumab) for the treatment of melanoma, making system into a powerful weapon against cancer. it the first PD-1 checkpoint inhibitor to receive FDA None of this would be possible without the generous approval and the third immunotherapy to be approved in support of our donors, who sustain our work and make just the past four years. tangible our vision of a world free from the fear of cancer. On behalf of our staff, our scientists, and our patients, Institutionally, CRI had a breakthrough year, as well. We thank you for all that you do to help CRI pursue its devoted $22 million to our programs—more than we mission to conquer cancer within our lifetimes.

01 From CRI’s Leadership 16 Awards and Honors James P. Allison, Ph.D. Jill O’Donnell-Tormey, Ph.D. 02 Breaking Through 18 Fiscal Year 2014 Director, Scientific Advisory Council CEO and Director of Scientific Affairs 04 Postdoctoral Program Grants and Awards 06 Clinic and Laboratory 29 Donors and Supporters Integration Program 45 Financials 08 Clinical Accelerator 47 Stewards of the 10 Thought Leadership Organization 55 Giving to the John B. Fitzgibbons Paul C. Shiverick 12 Patient Education Co-Chairman of the Board Cancer Research Institute Co-Chairman of the Board 14 Public Awareness

Kunle Odunsi, M.D., Ph.D., at Roswell Park Cancer Institute Member, CRI Scientific Advisory Council CANCER RESEARCH INSTITUTE 2014 ANNUAL REPORT 1 Dendritic cells (green) use their spiny tendrils to present antigens to T cells (red). Photo courtesy of Olivier Schwartz, Ph.D., Pasteur Institute

BREAKING THROUGH

or this year’s annual report, we chose the Ftheme “Breaking Through,” in recognition of the tremendous progress being made in the field of cancer immunotherapy. We at the Cancer Research Institute (CRI) know that the current state of optimism about immune-based treatments for cancer would not have been possible without the decades of research that came before. We also know that future advances will depend upon continued financial support of the entire research spectrum, from basic science, to translational research, to clinical trials. With its more than 60 years of funding research to understand the immune system and how it can be harnessed to conquer cancer, CRI is leading the way and ushering in a new era when patients, with all types of cancer, can be Cancer immunotherapy offers the treated and one day cured with immunotherapy. “greatest hope of transforming cancer treatment in our lifetimes. Jill O’Donnell-Tormey, Ph.D., CEO and Director of Scientific Affairs The Cancer Research Institute “has been very wise in putting the majority of its money into people who will develop new ideas. James Watson, Ph.D., co-discoverer of the 01 structure of DNA and CRI grantee 26 new grants BASICS AT THE BENCH Optimizing Therapeutics Numerous CRI postdoctoral fellows are conducting $4.3 CRI postdocs pursue research into improving the effectiveness of existing million awarded immunotherapies and understanding the mechanisms by tomorrow’s breakthroughs today which they work. From uncovering new cancer antigens that can be used in therapeutic vaccines, to developing new The CRI-IRVINGTON n medicine, the most important breakthroughs usually targets for genetically engineered T cells, to understanding POSTDOCTORAL FELLOWSHIP how checkpoint inhibitor antibodies work to stimulate the 03 PROGRAM, established Icome from research aimed at understanding fundamental immune response, CRI postdoctoral fellows are bringing in 1971, is CRI’s longest- biological mechanisms. CRI is currently supporting the basic research to bear on topics of great clinical importance. running continuous program. basic laboratory research of 90 postdoctoral fellows, with Fellowships provide up to the understanding that tomorrow’s cures will be built on the $164,500 over three years to solid foundation of today’s basic discoveries. Inflammation, Microbes, and Cancer support young immunologists Chronic inflammation is believed to promote the

POSTDOCTORAL and cancer immunologists development of several types of cancer, including studying at top universities Immune Evasion colorectal, liver, bladder, and lung cancers. CRI postdoctoral fellows are pursuing research aimed at understanding around the world. As cancer begins to develop, our immune system tries to eliminate the link between inflammation and cancer progression, it. However, immune cells are often unable to prevent cancer including the role that bacteria and viruses may play in this 02 04 development because their activity is inhibited in several ways, process. By finding ways to combat chronic inflammation, including by checkpoints that “put the brakes” on the immune scientists may one day be able to control the development response, and by regulatory cells that tell the immune system to “stand of inflammation-induced cancer, or prevent it altogether. down.” Cancer cells then escape detection and destruction by the 01 Noah W. Palm, Ph.D., and immune system and grow into tumors. CRI postdoctoral fellows are Watch the Video Nicola Gagliani, Ph.D. For a complete list of all exploring how immune evasion occurs and how it can be overcome, 02 Matthew Gubin, Ph.D. Gut Responses: Inflammation, Microbes, and Cancer with the hope of improving the effectiveness of immunotherapies. 03 Stefani Spranger, Ph.D. 90 postdoctoral fellows, www.bit.ly/gut-responses 04 Chunyu Jin, Ph.D. go to page 19.

CANCER RESEARCH INSTITUTE 2014 ANNUAL REPORT 5 I definitely believe that the work I’m doing “is going to benefit cancer patients. Ryan M. Teague, Ph.D., CLIP Investigator 12 new grants BETWEEN Pulling the Rug Out Beta-Blocker Therapy for When Cancer Starves the from Under Tumors Breast Cancer Immune System

$2.4 BENCH & Ellen Puré, Ph.D. Ming Li, Ph.D. Jeffrey Rathmell, Ph.D. million awarded Genentech Investigator Memorial Sloan Kettering Wade F.B. Thompson Investigator University of Pennsylvania Cancer Center Duke University Medical Center School of Veterinary Medicine New York, NY Durham, NC The CLINIC AND BEDSIDE Philadelphia, PA LABORATORY INTEGRATION PROGRAM (CLIP) supports Most conventional cancer therapies Suppression of the immune system Researchers have known for a long scientists who are exploring Where other funding agencies fear directly target cancer cells. In recent by cancer cells is believed to play an time that cancer cells compete with clinically relevant questions years, researchers have learned that important role in cancer progression. normal cells for energy and nutrients. aimed at improving the to tread, CLIP creates a bridge the cells surrounding a tumor are just Ming Li, Ph.D., is studying the Jeffrey Rathmell, Ph.D., is working immunosuppressive pathway that is to understand how this competition effectiveness of cancer as important. Ellen Puré, Ph.D., is activated in tumor-associated immune suppresses the immune system’s immunotherapies. CLIP grants ome of the most exciting questions in tumor using genetically engineered immune cells to kill the cancer-supporting cells in breast cancer models. This ability to fight cancer. In a model provide up to $200,000 over immunology today are ones being pursued at the “stromal” cells surrounding tumors. pathway is also the target of beta of kidney cancer, he has found

TRANSLATIONAL S two years. interface between basic and clinical research. Yet few Called chimeric antigen receptor blockers, which are used to treat high that cancer cells starve immune funding agencies focus on this translational research. (CAR) T cells, these engineered cells blood pressure and which have been cells of important nutrients such as CRI’s Clinic and Laboratory Integration Program (CLIP) contain a protein receptor that turns associated with increased survival glucose and amino acids, leaving T cells into cancer fighters. Dr. Puré among breast cancer patients. Dr. Li them unable to marshal an effective was launched in 2011 to serve this unmet need. Current has shown that these CAR T cells can is investigating whether beta blockers immune response and altering their CLIP scientists are pursuing novel therapeutic strategies inhibit the growth of lung tumors in target T cells to control breast tumor function. His work also suggests that informed by the cutting edge of both laboratory and mice. They are now exploring whether development, and is also working therapies designed to block immune clinical research. Their projects are bringing innovative this immunotherapy can enhance the to understand how this pathway checkpoints, such as anti-PD-1 regulates T cell responses to tumors, antibodies, may act in part by shifting For a complete list of all therapies for patients closer to reality. effectiveness of conventional therapies like chemotherapy and radiation. which may reveal novel targets for the this metabolic competition back in 24 CLIP investigators, immunotherapy of breast cancer. favor of immune cells. go to page 24.

CANCER RESEARCH INSTITUTE 2014 ANNUAL REPORT 7 Saving more lives 100 Unlike conventional therapies like chemotherapy and radiation, which typically only temporarily extend patient lives, immunotherapies are providing some patients with Combination immunotherapies

) durable remissions. Combining immunotherapies has the % potential to save more lives. l ( s u r v i a

t Cancer immunotherapy i e n 30+ POWERFUL t P a drugs accessed Patients still alive COMBINATIONS Conventional therapy No therapy $12 From brilliant scientists to innovative drugs, 0 million awarded CRI’s Clinical Accelerator brings the right Time ingredients together The CLINICAL ACCELERATOR is a venture philanthropy cientists increasingly recognize that the cancer treatments To date, CRI has announced collaborations with seven biopharma program designed to speed of tomorrow will be made up of combinations of different companies, including MedImmune/AstraZeneca, Immune Design, the development of cancer S CureVac, and VentiRx. CRI investigators now have access to a drugs that work in complementary fashion. At the same time, immunotherapies by facilitating “menu” of roughly 30 drugs from more than 15 companies, including The Clinical Accelerator research collaboration between it has become clear that existing models of drug development formal and informal partnerships. biopharma companies and are not well suited to testing these combinations in a smart “provides significant and The Clinical Accelerator is currently supporting over 20 clinical

CLINICAL TRIALS and coordinated fashion. Through its novel Clinical Accelerator academic cancer researchers. trials, including four that have already opened, six that are in immediate benefits to The program aims to identify program, CRI is enabling the strategic partnerships and drug planning stages, and another 12 for which it has supplied drugs. and kick-start the development combinations needed to generate the next cancer breakthroughs. All of these studies test novel combinations of immunotherapies patients, researchers, of new combination treatments for patients with a variety of different cancers, including melanoma, using the most promising drugs. Key to the success of the program is an innovative, collaborative cervical, colorectal, head and neck, kidney, and lung cancers. and industry. It’s is a model: CRI partners with leading biopharma companies to gain Immunotherapies being studied include several checkpoint inhibitors access to their drugs; CRI then provides nonprofit investment capital (anti-PD-L1, anti-CTLA-4) and immune modulators (anti-GITR, TLR3 win-win-win situation. to help fund clinical trials of drug combinations that scientists in our agonist), as well as vaccines targeting cancer-specific antigens. Just clinical network think are most promising, while our partner, Ludwig this past year, CRI committed funding to two new clinical trials—one Adam Kolom, Managing Director For a complete list of all Cancer Research, provides clinical trial management support. Industry for patients with advanced brain cancer, and another for patients with CRI-funded clinical trials, benefits by getting more shots on goal, CRI scientists benefit by advanced ovarian cancer. These groundbreaking clinical trials are gaining research knowledge to inform future trials, and patients benefit critical to designing better immunotherapies for patients, and Clinical go to page 25. by getting access to better immunotherapies sooner. Accelerator is making them happen faster.

CANCER RESEARCH INSTITUTE 2014 ANNUAL REPORT 9 MEETING OF THE MINDS For more than 20 years, CRI has been

The ANNUAL INTERNATIONAL convening scientists to discuss immunotherapy CANCER IMMUNOTHERAPY SYMPOSIUM is an annual etting scientists together in one place to meet and scientific meeting devoted to Gdiscuss new ideas has always been a valuable part of exploring the latest research the scientific enterprise—one no less important today in our in cancer immunology world of hyper-communication. and immunotherapy, and is attended by both basic Established in 1993, CRI’s annual combat cancer. The meeting also scientists and clinicians. scientific symposium focuses on included a poster session with progress in cancer immunology and presentations by 110 graduate immunotherapy. The theme of this students, postdoctoral fellows, and The CANCER past year’s meeting was “Dynamics other investigators, five of whom IMMUNOTHERAPY of Host-Tumor Interaction,” and were invited to deliver a lecture CONSORTIUM (CIC) convenes brought more than 325 scientists during the general session. the major stakeholders from from around the world to New York Since 2002, the Cancer academia, industry, regulatory City for three days last October. Immunotherapy Consortium bodies, and patient groups Among the many topics explored (CIC) has been working to make who share a common interest were the role of chronic inflammation immunotherapy the standard-of- in promoting immunotherapy in promoting cancer, the function care in oncology. In 2013, the CIC research and development. of the tumor stroma in promoting was reconceived as a “think tank” immune evasion, and the role of devoted to tackling the most urgent bacteria in shaping responses to matters in bringing new immune- cancer treatment. based treatment to the clinic and The symposium began with the through regulatory approval. Each inaugural William B. Coley lecture, year, one topic will be addressed delivered by Michael Karin, Ph.D., and a white paper produced. The topic chosen for 2014 was the winner of the 2013 William B. Coley Award. In his lecture, Dr. Karin development of surrogate endpoints discussed the role of inflammation for cancer immunotherapy. [The CRI symposium is] the milestone around and how it can both promote and “which we in the field of tumor immunology Watch the Video and immunotherapy now mark our progress. Putting out the Fire: Reducing Cancer-Causing Inflammation, with Dr. Michael Karin Steven A. Rosenberg, M.D., Ph.D., National Cancer Institute www.bit.ly/cancer-inflammation THOUGHT LEADERSHIP When I was dealing with prostate “ cancer and realized there were treatments designed to help THEANSWERTOCANCER.ORG boost the immune system so that it could detect the disease, I was NEW WEBSITE taken by that whole concept. Joe B., Prostate Cancer Survivor The first-of-its-kind cancer immunotherapy resource for patients and caregivers 01

s major advances in cancer immunotherapy Abegin to alter the landscape of cancer treatment, patients facing a cancer diagnosis need to be aware of immunotherapy as a potential treatment option. On June 1, 2014, CRI launched a new website designed specifically for cancer patients

and caregivers interested in learning about cancer 02 immunotherapy.

TheAnswerToCancer.org seeks to engage, educate, and empower patients and their loved ones to learn more about cancer immunotherapy as a treatment option across numerous tumor types. The website provides an accessible overview of the science behind cancer immunotherapy, detailed information about cancer immunotherapy clinical trials, and voices from the cancer immunotherapy community.

TheAnswerToCancer.org is supported through a charitable donation from Bristol-Myers Squibb.

PATIENT EDUCATION PATIENT Visit www.theanswertocancer.org to learn more.

01 Milton W., leukemia survivor 02 KayEllen G., ovarian cancer survivor, and daughter, Nicole PUBLIC AWARENESS T • • • • • Some highlightsofthemonth-longcampaigninclude: for research.$230,000 cancer in our lifetimes. It exceeded expectations, raising more than immunotherapy potential andits to transform treatment cancer second annualCancerImmunotherapyMonth™ Cancer ResearchInstitutecelebrates WORD OUT GETTING THE Cancer Immunotherapy Month™ to raise awareness of his past June, CRI annual celebrated second its sponsors and supporters at sponsors andsupporters Stand Up To Cancer, andmany others. Seeacomplete listof industry,biotech andbiopharmaceutical 1-800-flowers.com, AACR, for themonthincludedmembersof Sponsors andsupporters webinars canbeviewed at research inimmunotherapy istransforming theirtreatment. Past kidney cancer, andovarian cancerandabouthow groundbreaking about melanoma,lungcancer, prostatecancer, bladder cancer, offreeweekly educationalwebinarsA series helpedpeoplelearn 16.5 millionpeople. Associationforand theAmerican CancerResearch(AACR) reached A Twitter Chatco-sponsoredby CRI, #WhiteOutCancer Day. tosocialmediaonJune 6forMore thanhalfamillionpeopleturned lifesaving immunotherapy. “30 Days, 30Stories” theirexperiences ofpatientssharing with www.bit.ly/CRIwebinars www.bit.ly/2014CIMsupporters TIME magazine, Mayo Clinic, .

. 05 PeregrinePharmaceuticals 04 CarleyandLaura Rutledge 03 BilliBob,afeline supporter 02 NASDAQClosingBellCeremony 01 06 03 01 Sandra CoudertGraham’s twins

correspondent 08 07 Trilogy Lacrosse 06

CRI staffwithPBSNewsHour Roswell ParkCancerInstitute PaulSolman 02 04

07 CANCER RESEARCH INSTITUTE 05 08 2014ANNUAL REPORT 15 RECOGNIZING EXCELLENCE Each year, CRI honors those individuals who have made important contributions to the field of cancer immunotherapy

WILLIAM B. COLEY AWARD FOR DISTINGUISHED RESEARCH IN BASIC AND TUMOR IMMUNOLOGY Michael B. Karin, Ph.D. Professor of Pharmacology and Pathology University of California, San Diego

FREDERICK W. ALT AWARD FOR NEW DISCOVERIES IN IMMUNOLOGY Jill O’Donnell-Tormey, Ph.D. CEO and Director of Scientific Affairs Cancer Research Institute 01 It is my firm belief...that AACR-CRI LLOYD J. OLD AWARD IN CANCER IMMUNOLOGY Robert D. Schreiber, Ph.D. “the end of cancer is Alumni Endowed Professor of Pathology and Immunology actually closer at hand Washington University School of Medicine than anyone outside of OLIVER R. GRACE AWARD FOR DISTINGUISHED SERVICE this room even realizes. IN ADVANCING CANCER RESEARCH Sean Parker, Serial Tech Bahija Jallal, Ph.D. Executive Vice President, AstraZeneca Entrepreneur and Philanthropist Head, MedImmune Sean Parker 02 03 Serial Tech Entrepreneur and Philanthropist 01 Honorees, presenters, and co-chairmen 02 Glenn Dranoff, M.D., and Michael B. Karin, Ph.D. 03 Carl H. June, M.D., with leukemia survivor Emily

AWARDS & HONORS AWARDS Whitehead and her parents, Kari and Tom

Watch the award videos at www.bit.ly/2014CRIawards

CANCER RESEARCH INSTITUTE 2014 ANNUAL REPORT 17 Student Training and Predoctoral Emphasis CRI-Irvington Postdoctoral Research in Tumor Pathways in Tumor Fellowship Program Immunology (STaRT) Immunology Three-year awards that further the Program Four-year awards to universities career development and advanced laboratory research of promising Two-year awards that attract bright to support establishment and postdoctoral fellows working young minds to rewarding careers maintenance of tumor immunology under the mentorship of world- as cancer immunologists by funding training courses for graduate students. class immunologists and tumor graduate studies in tumor immunology immunologists. at top universities. Harvard Medical School, Boston, MA Directors: Glenn Dranoff, M.D., and Antibody Structure and Diversity Thomas Chia Ting Fung Michael Carroll, Ph.D. Perelman School of Medicine at Jiazhi Hu, Ph.D.* the University of Pennsylvania, Johns Hopkins University School of Boston Children’s Hospital, Philadelphia, PA Medicine, Baltimore, MD Boston, MA Role of innate lymphoid cell- Director: Charles G. Drake, M.D., Ph.D. Mechanisms that target AID for controlled intestinal barrier function in antibody gene diversification and for hepatocellular carcinoma QIMR Berghofer Medical Research Institute, Queensland, Australia oncogenic chromosomal translocations Robertson Foundation Fellow Alexandria Huynh Director: Mark J. Smyth, Ph.D. Massachusetts General Hospital, Feilong Meng, Ph.D. Boston, MA University of Colorado, Denver, CO Boston Children’s Hospital, The role of PTEN in regulatory T cell Directors: John Kappler, Ph.D., and Boston, MA stability and immune surveillance Philippa Marrack, Ph.D. Role of co-factors in targeting activation-induced cytidine Jenny Karo University of Washington School of deaminase activity during class Memorial Sloan Kettering Cancer Medicine, Seattle, WA switch recombination and somatic Center, New York, NY Director: Philip D. Greenberg, M.D. hypermutation Elucidating the regulatory role of CTLA-4 on natural killer cell responses Washington University School of Medicine, St. Louis, MO Qi Qiao, Ph.D. Boston Children’s Hospital, Albert Lo Director: Robert D. Schreiber, Ph.D. Boston, MA Perelman School of Medicine at Mechanistic elucidation of activation- the University of Pennsylvania, Weill Cornell Medical College, induced deaminase (AID) in immunity Philadelphia, PA New York, NY Directors: Alexander Y. Rudensky, and cancer Regulation of inflammatory and Roy Louis Maute, Ph.D., CRI postdoctoral fellow immune response to pancreatic cancer Ph.D., and Carl F. Nathan, M.D. Beth M. Stadtmueller, Ph.D. at Stanford University School of Medicine by FAP+ stromal cells Immunology/Tumor Immunology California Institute of Technology, Pasadena, CA Tangsheng Yi, Ph.D. Thornton William Thompson Training Course The structural and molecular basis University of California, San Francisco, University of California, Berkeley, San Francisco, CA Lomonosov Moscow State University, of polymeric IgA function in mucosal Berkeley, CA Role of EBI2 and its oxysterol ligands Moscow, Russia immunity and associated cancers The role of oncogene-induced in adaptive immunity senescence in promoting anti-tumor Course Coordinator: Sergei A. In fiscal year 2014 (July 1, 2013, to June 30, 2014), Nedospasov, Ph.D., D.Sc.* Leng Siew Yeap, Ph.D. immune responses Hye Suk Yoon, Ph.D. The Lloyd J. Old Advanced Training Boston Children’s Hospital, Boston Children’s Hospital, CRI awarded more than $19 million for cancer Program in Immunology and Boston, MA Boston, MA Oncoimmunology Mechanisms by which DNA sequence immunology research and cancer immunotherapy influence AID targeting in antibody Elucidation of V(D)J recombination clinical development. diversity and B lymphocyte cancer control elements in the IgH locus *Denotes grants newly awarded in fiscal year 2014. All others are active grants CRI Scientific Advisory Council member Lisa M. Coussens, Ph.D., awarded in previous years. with postdoctoral fellow at Oregon Health & Science University

CANCER RESEARCH INSTITUTE 2014 ANNUAL REPORT 19 FISCAL YEAR 2014 GRANTS & AWARDS Paola A. Betancur, Ph.D. Hyang-Mi Lee, Ph.D.* James A. Harker, Ph.D. Justin J. Taylor, Ph.D. Jason Hudak, Ph.D.* Mo Xu, Ph.D. Stanford University School of University of California, San Diego, University of California, San Diego, University of Minnesota, Harvard Medical School, Boston, MA NYU Langone Medical Center, Medicine, Stanford, CA La Jolla, CA La Jolla, CA Minneapolis, MN Understanding microbial sensing in New York, NY In search of the gene regulatory Targeting regulatory T cell-mediated The role of gp130 associated cytokines Direct tracking of vaccine-specific B colorectal cancer using bioorthogonal Intestinal microbiota-induced Th17 circuitry responsible for the regulation of IFNγ-driven anti-tumor in chronic viral infection cells from naïve precursors chemistry responses in systemic inflammatory transcriptional upregulation of CD47, immunity disease the “don’t eat me” signal in cancer Alice O. Kamphorst, Ph.D. Inflammation, Microbes, Cancer Chunyu Jin, Ph.D. Margaret Dammann Eisner Fellow cells Roy Louis Maute, Ph.D.* Emory University, Atlanta, GA University of California, San Diego, Stanford University School of Role of dendritic cells in T cell Michael C. Abt, Ph.D.* La Jolla, CA Zhenyu Zhong, Ph.D.* Juan R. Cubillos-Ruiz, Ph.D. Medicine, Stanford, CA dysfunction during chronic viral Memorial Sloan Kettering Cancer Genomic approaches to roles of GPS2 University of California, San Diego, Weill Cornell Medical College, Characterization of the MHC/ infections Center, New York, NY in innate immunology dependent La Jolla, CA New York, NY LILRB signaling axis as an Innate immune regulation of C. events in prostate cancer Identification of key immune XBP1 as a key regulator of dendritic immunotherapeutic target in cancer Mickael Mathieu Menager, Ph.D. difficile-driven inflammation homeostatic regulators that control cell pro-tumoral activity NYU Langone Medical Center, Kiwook Kim, Ph.D. obesity-induced liver inflammation and Ying Zheng, Ph.D. New York, NY Maureen Ann Cox, Ph.D. Yale School of Medicine, disease Yongqiang Feng, Ph.D. Johns Hopkins University Molecular mechanisms of dendritic University Health Network, New Haven, CT CRI postdoctoral fellow Juan R. Cubillos-Ruiz, Ph.D., with Stanley Adoro, Ph.D., Memorial Sloan Kettering Cancer School of Medicine, Baltimore, MD cell-mediated transfer of HIV-1 to Toronto, Canada GBP5-NOD2 interactions in Joshua W. Ziel, Ph.D. at Weill Cornell Medical College Center, New York, NY The role of HIF-1 in adaptive T cell CD4+ T lymphocytes Investigation of the role of HMGB1 gastrointestinal host defense, colitis, NYU Langone Medical Center, Role of conserved non-coding responses to cancer in asbestos-driven inflammation and and colon cancer New York, NY Gene Expression and Development Sara Trifari, Ph.D. elements of Foxp3 in regulatory T cell Donald J. Gogel Fellow James B. Munro, Ph.D. mesothelioma development Commensal control of intestinal Th17: La Jolla Institute for Allergy and development and function Yale School of Medicine, Noah Wolcott Palm, Ph.D. Treg balance during homeostasis and Bradley Wayne Blaser, M.D., Ph.D.* Immunology, La Jolla, CA Bristol-Myers Squibb Fellow Infectious Disease and New Haven, CT Liron David, Ph.D. Yale School of Medicine, carcinogenesis Boston Children’s Hospital, Identification and functional Autoimmunity Single-molecule imaging of immune Boston Children’s Hospital, New Haven, CT Boston, MA characterization of novel epigenetic Ross B. Fulton, Ph.D. evasion by HIV Env Boston, MA Role of helminth infections and the Novel Therapeutics Immunologic regulation of and transcriptional regulators of CD8+ University of Minnesota, Tessa Bergsbaken, Ph.D. Molecular elucidation of the CBM commensal microbiota in intestinal hematopoietic stem cell engraftment T cell differentiation Minneapolis, MN University of Washington School of Blaise Ndjamen, Ph.D. complex in NFκB activation by antigen inflammation Evelyn Dixit, Ph.D.* Naïve CD8+ T cells differ in their Medicine, Seattle, WA California Institute of Technology, receptors Boston Children’s Hospital, Jing-Ping Hsin, Ph.D.* Ageliki Tsagaratou, Ph.D. ability to respond to tumor-associated A T cell intrinsic role for Caspase-1 in Pasadena, CA April Price, Ph.D. Boston, MA Memorial Sloan Kettering Cancer La Jolla Institute for Allergy and antigen the immune response A model system to investigate Timothy Eitas, Ph.D. University of California, Berkeley, Spatiotemporal regulation of RIG-I Center, New York, NY Immunology, La Jolla, CA antibody bipolar bridging mediated by University of North Carolina at Chapel Berkeley, CA paves the way for novel cancer The effects of cellular context on Dissecting the role of 5 Georg A.J. Gasteiger, M.D. Jonathan M. Clingan, Ph.D.* gE-gI, a Herpes virus Fc receptor Hill, Chapel Hill, NC Expression and function of Toll-like immunotherapies miR-155 mediated regulation of gene hydroxymethylcytosine in T cell Memorial Sloan Kettering Cancer University of Washington School of Regulation of colitis-associated cancer receptors in intestinal epithelial cells expression development, homeostasis, and Center, New York, NY Medicine, Seattle, WA Lisa C. Osborne, Ph.D. by NLRX1 Haidong Tang, Ph.D.* Young Philanthropists Council Fellow function Regulation of cytotoxic killer cells by Integration of transcriptional and Perelman School of Medicine at the Rajesh R. Rao, Ph.D. University of Chicago, Chicago, IL Foxp3+ regulatory T cells translational control of the anti-viral University of Pennsylvania, Nicola Gagliani, Ph.D. Dana-Farber Cancer Institute, Tumor-specific LIGHT targeting for Shengdong Ke, Ph.D. Yina Zhu, Ph.D. response Philadelphia, PA Yale School of Medicine, Boston, MA cancer immunotherapy The Rockefeller University, University of California, San Diego, Yenkel Grinberg-Bleyer, Ph.D. Regulation of protective immunity New Haven, CT Novel exercise-induced myokines New York, NY La Jolla, CA Columbia University Medical Center, Pu Gao, Ph.D.* following enteric viral infection Targeting Th17 cell plasticity to control as modulators of inflammation and Li Tang, Ph.D. RNA epigenetic HITS-CLIP: A new Mechanisms that underpin the New York, NY Memorial Sloan Kettering Cancer Edmond J. Safra Fellow colorectal cancer development defense against chronic diseases Massachusetts Institute of Technology, approach to understanding leukemia/ sequestration of the tumor suppressor Testing the role of NFκB in tumor Center, New York, NY Dr. Keith Landesman Memorial Fellow Cambridge, MA lymphoma ebf1 at the nuclear lamina immunity through its effect on Structural and functional studies of Read Pukkila-Worley, M.D. Nathan R. West, Ph.D. T lymphocyte engineering with regulatory T cells cytosolic DNA sensing pathway Massachusetts General Hospital, Wendy Jia Men Huang, Ph.D. University of Oxford, interleukin 2-silica nanocapsules for You Jeong Lee, M.D., Ph.D. Immune Evasion Robertson Foundation Fellow Boston, MA NYU Langone Medical Center, Oxford, United Kingdom targeted cancer therapy University of Minnesota, Sudha Kumari, Ph.D. A novel live-animal system for the New York, NY Analysis of novel susceptibility genes Minneapolis, MN Michele Ardolino, Ph.D. NYU Langone Medical Center, Elizabeth Gray, Ph.D. characterization of anti-fungal innate Molecular mechanisms underlying in chronic intestinal inflammation and John T. Wilson, Ph.D. IL-4 produced by iNKT cells directs the University of California, Berkeley, New York, NY University of Washington School of immunity SFB-Th17 induction and intestinal colon cancer University of Washington School of development of memory CD8+ T cells Berkeley, CA Characterization of a novel molecular Medicine, Seattle, WA tumor pathogenesis Medicine, Seattle, WA MHC-deficient tumors inactivate compartment modulating regulatory T Functional analysis of the interferon Nicole L. Sullivan, Ph.D. Margaret Dammann Eisner Fellow A new class of multifunctional smart Chan-Wang J. Lio, Ph.D. infiltrating NK cells: A new target for cell function stimulatory DNA pathway Emory University, Atlanta, GA polymers for cancer vaccine delivery La Jolla Institute for Allergy and cancer immunotherapy Development of human CD4+ T cell Immunology, La Jolla, CA memory against viruses Role of long non-coding RNAs in the development of T cell leukemia

CANCER RESEARCH INSTITUTE 2014 ANNUAL REPORT 21 Optimizing Therapies Kristen E. Pauken, Ph.D.* Maria P. Frushicheva, Ph.D.* Qi Wang, Ph.D. Brian R. Graziano, Ph.D.* Investigator Awards Sergio A. Quezada, Ph.D. Perelman School of Medicine at Massachusetts Institute of Technology, University of California, Berkeley, University of California, San Francisco, Four-year bridging grants to assistant University College London Cancer Margaret Callahan, M.D., Ph.D. the University of Pennsylvania, Cambridge, MA Berkeley, CA San Francisco, CA professors undertaking their first Institute, London, United Kingdom Memorial Sloan Kettering Cancer Philadelphia, PA ZAP-70 and Syk regulation in B cell Molecular mechanisms of T cell Using optogenetics to probe the in independent investigations in basic Mechanisms underpinning the Center, New York, NY Anti-PD-1 immunotherapy: chronic lymphocytic leukemia activation by the tyrosine kinase Lck vivo biochemistry of cell movement and tumor immunology, designed to function of regulatory and effector Immunologic effects of BRAF Mechanisms and impact on and ZAP-70 provide flexibility and stability while tumor-reactive CD4+ T cells inhibitors: Towards the rational sustainability of CD8+ T cell responses Jeffrey E. Grotzke, Ph.D. Jesse Green, Ph.D. they establish their laboratories. during tumorigenesis and cancer development of multi-modality therapy Robertson Foundation Fellow Yale School of Medicine, Tumor Microenvironment Memorial Sloan Kettering Cancer immunotherapy for advanced melanoma New Haven, CT Center, New York, NY Wendy S. Garrett, M.D., Ph.D. Lloyd J. Old Memorial Fellow Helene M. Salmon, Ph.D.* Membrane receptors and associated Alexandra Boussommier, Ph.D.* Interactions of regulatory T cells with Harvard School of Public Health, Peter A. Savage, Ph.D. Icahn School of Medicine at Mount signaling pathways in cross Massachusetts Institute of Technology, the tumor endothelium and effects on Boston, MA University of Chicago, Chicago, IL Carmen Gerlach, Ph.D.* Sinai, New York, NY presentation Cambridge, MA the tumor microenvironment The role of inflammatory monocytes Endogenous CD4+ regulatory T cell and Harvard Medical School, Boston, MA Contribution of the cutaneous myeloid Characterizing the role of Samuel and Ruth Engelberg Fellow and the gut microbiota in colorectal CD8+ T cell responses in a mouse model Differentiation, function, and dynamic network to melanoma response to Bengt Martin Gustavsson, Ph.D.* macrophages in breast cancer cell cancer of autochthonous prostate cancer behavior of transitional memory cells therapy University of California, San Diego, extravasation and recolonization in Corrie Ann Painter, Ph.D.

(TTM): A novel subset of CD8+ memory Robertson Foundation Fellow La Jolla, CA organ-specific 3D microfluidic models University of Massachusetts Medical Dimitrios Iliopoulos, Ph.D. Joseph C. Sun, Ph.D. T cells Structural basis of CXCR7 ligand School, Worcester, MA UCLA Medical Center, Los Angeles, CA Memorial Sloan Kettering Cancer Xiaolei Su, Ph.D. binding and signaling Hsin Chen, Ph.D.* Investigating the adaptive immune Identification of novel molecular Center, New York, NY Matthew M. Gubin, Ph.D.* University of California, San Francisco, Robertson Foundation Fellow University of California, San Francisco, response to melanoma in the zebrafish circuits that link inflammation to Natural killer cell responses against Washington University School of San Francisco, CA San Francisco, CA Danio rerio cancer cancer and infectious disease Medicine, St. Louis, MO Mechanisms underlying the dynamic Vincent Christopher Luca, Ph.D. Mechanisms controlling lymphocyte Using genomics to identify targets of organization of T cell microclusters Stanford University School of retention in and egress from tissue Edward W. Roberts, Ph.D.* Estela P. Jacinto, Ph.D. Ryan M. Teague, Ph.D. checkpoint blockade cancer treatment Eugene V. Weissman Fellow Medicine, Stanford, CA University of California, San Francisco, UMDNJ-RWJ Medical School, Saint Louis University School of and to identify optimal target antigens Deconstructing the structural Viviana Cremasco, Ph.D. San Francisco, CA Piscataway, NJ Medicine, St. Louis, MO for vaccination Adam Williamson, Ph.D.* mechanisms of cytokine-mediated JAK Dana-Farber Cancer Institute, Lifespan, fate, and function of immune mTOR targets in T lymphocyte Overcoming obstacles for improved University of California, San Francisco, activation Boston, MA cells educated in primary tumors development adoptive T cell immunotherapy Jin-Hwan Han, Ph.D. San Francisco, CA Targeted disruption of tumor matrix Emory University, Atlanta, GA Activation of corpse engulfment to Boryana N. Manz, Ph.D. architecture to restore cancer Stefani Spranger, Ph.D.* Jennifer M. Lund-Friesen, Ph.D. Liang Zhou, M.D., Ph.D. Enhanced anti-tumor immunity by alleviate tumor-induced neurotoxicity University of California, San Francisco, immunosurveillance University of Chicago, Chicago, IL Fred Hutchinson Cancer Research Northwestern University, Evanston, IL regulation of IgG sialylation San Francisco, CA The role of tumor-intrinsic oncogene Center, Seattle, WA Molecular mechanisms of action of Ahr Signaling and Cell Communication Negative regulation of SFK and Ras alterations in immune evasion of Regulatory T cell modulation of in T cell differentiation and function David L. Lampi Hermanson, Ph.D.* by Dok1 melanoma immunity to mucosal viral infections University of Minnesota, John S. Burg, Ph.D. Minneapolis, MN Stanford University School of Giulia Pasqual, Ph.D. Chimeric antigen receptor directed NK Medicine, Stanford, CA Whitehead Institute for Biomedical cellular immunotherapy Structural studies of Wnt receptor Research, Cambridge, MA CRI postdoctoral fellows Georg A.J. Gasteiger, M.D., and Jesse Green, Ph.D., wiith CLIP investigator Alexander Y. Rudensky, Ph.D., at Memorial Sloan Kettering Cancer Center activation In vivo tracking of B cell-T cell Lingfeng Liu, Ph.D. interactions in the germinal center University of California, San Francisco, Anne Marie Christine Chauveau, Ph.D San Francisco, CA Memorial Sloan Kettering Cancer Debrup Sengupta, Ph.D. Optimizing T cells for cancer therapy: Center, New York, NY Yale School of Medicine, A synthetic biology approach Role of DGKα in cytoskeleton New Haven, CT remodeling and T cell effector Membrane trafficking events Yvonne K. Mburu, Ph.D. functions regulating cross presentation Institut Curie, Paris, France Mucosal-associated invariant T (MAIT) Adam H. Courtney, Ph.D.* Vanja Sisirak, Ph.D. cells in anti-tumor therapy University of California, San Francisco, Columbia University Medical Center, Lloyd J. Old Memorial Fellow San Francisco, CA New York, NY Elucidation of Lck feedback Novel regulator of DNA recognition by mechanisms dendritic cells Robertson Foundation Fellow

Sergio A. Quezada, Ph.D., CRI investigator at the University College London Cancer Institute Clinic and Laboratory Jonathan S. Cebon, Ph.D., FRACP Rakesh K. Jain, Ph.D.* Ellen Puré, Ph.D. Ryan M. Teague, Ph.D.* Clinical Accelerator Trials Integration Program (CLIP) Austin Health/Ludwig Cancer Massachusetts General Hospital, University of Pennsylvania Saint Louis University School of The Clinical Accelerator brings Research, Melbourne, Australia Boston, MA School of Veterinary Medicine, Medicine, St. Louis, MO Two-year grants that provide catalytic together the best capabilities of the Evaluation of ROPN and SPANX Improving immunotherapy for Philadelphia, PA Defining the mechanisms of human support for translational laboratory world’s leading academic researchers, as targets for antigen-specific metastatic breast cancer via Adoptive T cell therapy targeted to T cell rescue by checkpoint blockade studies designed to answer new drug companies, and a unique immunotherapy normalization of the tumor tumor stroma to treat lung cancer immunotherapy scientific questions that arise in the nonprofit venture fund to kick-start Wade F.B. Thompson Investigator microenvironment Genentech Investigator clinic, with special focus on improving the development of powerful new immunotherapy for cancer patients. Coordinated Cancer treatments for cancer patients. To Dean W. Felsher, M.D., Ph.D.* Susan M. Kaech, Ph.D.* Jeffrey C. Rathmell, Ph.D. Initiatives view a list of all current sites and lead Stanford University School of Yale School of Medicine, Duke University Medical Center, Gosse J. Adema, Ph.D. Funding for research in specified investigators, go to page 50. Medicine, Stanford, CA New Haven, CT Durham, NC Radboud University Medical Centre, cancer areas deemed able to provide Oncogene addiction and immune Enhancing immunotherapy-based Metabolic immunosuppression of T Nijmegen, The Netherlands clinically relevant insights and Funded Studies activation cancer treatments through CD40- cells in clear cell renal cell carcinoma Exploiting in situ tumor destruction discoveries with the potential to dependent immunomodulation of the and anti-PD-1 therapy techniques for the in vivo modulation accelerate development of cancer A first-in-human single ascending Ian Hector Frazer, M.D., FRCPA tumor microenvironment Wade F.B. Thompson Investigator of anti-tumor immunity immunotherapies. dose study of TRX518 in subjects University of Queensland, Wade F.B. Thompson Investigator with unresectable stage III or stage Queensland, Australia Jeffrey V. Ravetch, M.D., Ph.D. Matteo Bellone, M.D.* Maha Ayyoub, Ph.D., and IV malignant melanoma or other solid Optimizing immunotherapy for W. Martin Kast, Ph.D. The Rockefeller University, Fondazione Centro San Raffaele, Danila Valmori, Ph.D. tumor malignancies squamous cancer University of Southern California, New York, NY Milan, Italy Centre de Lutte Contre Le Cancer • Henry Koon, M.D., University Los Angeles, CA Enhancing the immunotherapeutic Combining adoptive T cell therapy to Nantes-Atlantique, Nantes, France Hospitals, Cleveland, OH Thomas F. Gajewski, M.D., Ph.D. Anti-CTLA-4 immune modulation activity of anti-CD40 antibodies tumor vessel targeting and checkpoint Vaccination strategies for the • Dale Shepard, M.D., Ph.D., University of Chicago, Chicago, IL following chemoradiation in cervical blockade for cancer therapy treatment of epithelial ovarian Cleveland Clinic, Cleveland, OH Identification of tumor-intrinsic cancer patients Alexander Y. Rudensky, Ph.D.* cancer; Placenta-cancer antigens as • Jedd D. Wolchok, M.D., Ph.D., and signaling pathways that inhibit host Memorial Sloan Kettering Cancer Nina Bhardwaj, M.D., Ph.D. potential targets for immunotherapy of Margaret Callahan, M.D., Ph.D., immune responses as potential Paul Klenerman, M.D., Ph.D.* Center, New York, NY Icahn School of Medicine at Mount epithelial ovarian cancer Memorial Sloan Kettering Cancer Sinai, New York, NY therapeutic targets to expand the University of Oxford, Immunoregulatory correlates of a Center, New York, NY applicability of immunotherapy Oxford, United Kingdom phase I/II study of mogamulizumab Antoni Ribas, M.D, Ph.D., CVC Trials Network member, with investigator at UCLA Medical Center MMP-2 promotes melanoma Hearn Jay Cho, M.D., Ph.D. Oliver R. Grace Investigator Licensing human MAIT cells to kill in subjects with advanced and/or progression through Toll-like receptor Icahn School of Medicine at Mount A phase I study of NY-ESO-1 vaccine hepatocellular carcinomas metastatic solid tumors mediated mechanisms Sinai, New York, NY in combination with ipilimumab Michael Goldberg, Ph.D.* Genentech Investigator A phase II study to evaluate the Wade F.B. Thompson Investigator Vaccine immunotherapy program in in patients with unresectable or A phase I study to evaluate the Dana-Farber Cancer Institute, Ming O. Li, Ph.D. clinical efficacy and safety of multiple myeloma metastatic melanoma, for whom safety and tolerability of anti-PD-L1, Bruce R. Blazar, Ph.D.* Boston, MA Memorial Sloan Kettering Cancer Bruno Sainz Jr., Ph.D.* treatment with ipilimumab is indicated MEDI4736, in combination with standards of care in combination with Use of CRISPR/Cas9 platform to Center, New York, NY Universidad Autónoma de Madrid, checkpoint blockade in patients with University of Minnesota, Pramod K. Srivastava, M.D., Ph.D. • Jonathan S. Cebon, Ph.D., FRACP, tremelimumab in subjects with improve function of cytotoxic T The Adrb-cAMP-ICER pathway in Madrid, Spain glioblastoma* Minneapolis, MN University of Connecticut School of Austin Health/Ludwig Cancer advanced solid tumors lymphocytes against melanoma control of mammary tumor immune Role of the innate immune system in • David Reardon, M.D., Dana-Farber Lymphoid organ repair after cancer Medicine, Farmington, CT Research, Melbourne, Australia • Kunle Odunsi, M.D., Ph.D., Anna- evasion promoting cancer stem cells Cancer Institute, Boston, MA therapy for improving anti-tumor Genomics-driven identification of true • Craig E. Devoe, M.D., North Maria Kellen Clinical Investigator, immune responses tumor-specific antigens and their use Shore LIJ, North Shore University Roswell Park Cancer Institute, Roger S. Lo, M.D., Ph.D.* Robert D. Schreiber, Ph.D. Phase I/II study of chemo- in immunotherapy of spontaneous Hospital, Manhasset, NY Buffalo, NY UCLA Medical Center, Los Angeles, CA Washington University School of immunotherapy with Toll-like receptor prostate cancers • Philip Friedlander, M.D., Icahn • Patrick Ott, M.D., Ph.D., Dana- Determinants of responses to Medicine, St. Louis, MO School of Medicine at Mount Sinai, Farber Cancer Institute, Boston, MA 8 agonist VTX-2337 and checkpoint anti-PD-1/PD-L1 therapy and its A genomics-based approach to New York, NY • Jedd D. Wolchok, M.D., Ph.D., and blockade in subjects with recurrent, combination with BRAF/MEK co- facilitate checkpoint blockade cancer • Michael A. Postow, M.D., Memorial Margaret Callahan, M.D., Ph.D., platinum-resistant ovarian cancer targeting in melanoma immunotherapy Sloan Kettering Cancer Center, Memorial Sloan Kettering Cancer for whom pegylated liposomal Wade F.B. Thompson Investigator New York, NY Center, New York, NY doxorubicin (PLD) is indicated* Mark J. Smyth, Ph.D.* • Craig L. Slingluff Jr., M.D., • George Coukos, M.D., Ph.D., Hiroyoshi Nishikawa, M.D., Ph.D. QIMR Berghofer Medical Research University of Virginia Cancer University Hospital of Lausanne, Osaka University, Osaka, Japan Institute, Queensland, Australia Center, Charlottesville, VA Lausanne, Switzerland Novel cancer immunotherapy targeting The preclinical validation of CD96 • Hussein Tawbi, M.D., Ph.D., regulatory T cells by anti-CCR4 as a checkpoint target for cancer University of Pittsburgh Cancer monoclonal antibodies immunotherapy Institute, Pittsburgh, PA

Nina Bhardwaj, M.D, Ph.D., CLIP investigator, with postdoctoral fellows at the CANCER RESEARCH INSTITUTE 2014 ANNUAL REPORT 25 Icahn School of Medicine at Mount Sinai A phase I study of vaccination Phase I/II trial of a long peptide Phase II study of CTLA-4 blockade Leveraged Grants Malcolm A.S. Moore, D.Phil.* Frederick W. Alt Award for New with NY-ESO-1 protein mixed with vaccine (LPV8) + TLR agonists for and low dose cyclophosphamide in Special partnerships to explore novel Memorial Sloan Kettering Cancer Discoveries in Immunology Poly-ICLC, OK-432 (Picibanil®), and resected stage IIB-IV (Mel60)* patients with advanced malignant preclinical and clinical studies in high- Center, New York, NY Prize honoring a former postdoctoral ISA-51 (Montanide®) in patients • Craig L. Slingluff Jr., M.D., melanoma after failure of at least one priority research areas. The study of hematopoietic stem cells fellow in recognition of outstanding with advanced cancers expressing University of Virginia Cancer prior therapy and progenitor populations in normal success in academia or industry for NY-ESO-1 antigen Center, Charlottesville, VA • Nina Bhardwaj, M.D., Ph.D., Icahn Cancer Immunology Translational and cancer cells research that may have a potentially • Yuichiro Doki, Ph.D., and Hisashi School of Medicine at Mount Sinai, Research Dream Team Gar Reichman Laboratory major impact on immunology. Wada, M.D., Ph.D., Osaka Safety and immunogenicity of New York, NY James P. Allison, Ph.D., The University Jill O’Donnell-Tormey, Ph.D.* University, Osaka, Japan vaccination with XAGE1b long • Anna C. Pavlick, D.O., NYU Langone of Texas MD Anderson Cancer Center, ZERO-The End of Prostate Cancer, Cancer Research Institute peptides combined with Poly-ICLC in Medical Center, New York, NY Houston, TX, and Antoni Ribas, M.D., Washington, DC* A phase IA/IB study of vaccination patients with stage III/IV pulmonary Ph.D., UCLA Medical Center, Los Support for the Drive Against Prostate Oliver R. Grace Award for with NY-ESO-1 protein, Poly-ICLC, and adenocarcinoma Preclinical toxicity studies to enable Angeles, CA Cancer mobile screening vehicle Distinguished Service in mogamulizumab in patients with adult • Christian Taube, M.D., and the clinical development of the Immunologic checkpoint blockade Advancing Cancer Research T cell leukemia/lymphoma expressing Maarten L. Zandvliet, Ph.D., Leiden XAGE1b peptide vaccine and adoptive T cell transfer in cancer Annual Awards Annual prize that recognizes the NY-ESO-1 antigen University Medical Center, Leiden, • Cornelis J.M. Melief, M.D., Ph.D., therapy In addition to providing financial contributions of dedicated laypersons • Yuzuru Kanakura, Ph.D., and The Netherlands Leiden University Medical Center, In partnership with the Entertainment support to researchers and whose leadership has had a significant Hiroyoshi Nishikawa, M.D., Ph.D., Leiden, The Netherlands Industry Foundation/Stand Up To investigators, CRI also honors impact on cancer research. Osaka University, Osaka, Japan Correlative and Laboratory Studies Cancer scientists and community leaders with Bahija Jallal, Ph.D.* Vaccination of melanoma patients achievement awards. AstraZeneca/MedImmune A pilot study of a novel multimodality Development of cancer (stage II-IV) with ImmuFact IMP321, Carl H. June, M.D., and Gregory L. Sean Parker* immuno-chemotherapy platform for immunotherapy targeting regulatory tumor antigenic peptides, and Beatty, M.D., Ph.D. William B. Coley Award for Serial Tech Entrepreneur and patients with advanced cutaneous T T cells Montanide Perelman School of Medicine at Distinguished Research in Basic Philanthropist cell lymphoma • Hiroyoshi Nishikawa, M.D., Ph.D., • Daniel E. Speiser, M.D., University the University of Pennsylvania, and Tumor Immunology • Catherine M. Diefenbach, M.D., Osaka University, Osaka, Japan Hospital of Lausanne, Lausanne, Philadelphia, PA Annual prize given to one or more NYU Langone Medical Center, New Switzerland Mesothelin-specific chimeric antigen scientists whose discoveries in York, NY Early-phase NY-ESO-1 clinical trials receptor (CAR) T cell therapy for the fields of immunology or tumor in patients with epithelial ovarian, Reagent Manufacture pancreatic cancer immunology contribute to the A pilot study of the immunogenicity of fallopian tube, or primary peritoneal In partnership with the Lustgarten advancement of immune system- a 9-peptide breast cancer vaccine plus carcinoma and monitoring of tumor- Production of NY-ESO-1 overlapping Foundation based therapies for cancer. Poly-ICLC in stage IB-IIIA breast cancer specific immune responses peptides for use in a variety of trials Michael B. Karin, Ph.D.* • Patrick M. Dillon, M.D., University • Maha Ayyoub, Ph.D., and Danila • PolyPeptide Laboratories San Designated Grants University of California, San Diego of Virginia Cancer Center, Valmori, Ph.D., Centre de Lutte Diego, San Diego, CA Grants to support research projects Trials Supported with Reagents A phase I study of cancer vaccine Charlottesville, VA Contre Le Cancer Nantes- and public education and awareness Lloyd J. Old Award in Cancer CHP-NY-ESO-1 in combination with Atlantique, Nantes, France Poly-ICLC stability testing initiatives for which, in most cases, Immunology A multi-peptide vaccine plus Toll-like Poly-ICLC in patients with esophageal Evaluation of safety and • Oncovir, Inc., Washington, DC donors have specifically raised funds. Award recognizes an active scientist receptor agonists in melanoma cancer or malignant melanoma immunogenicity of a multi- Immunological monitoring for the CVC whose outstanding and innovative patients, with evaluation of the expressing NY-ESO-1 phosphapeptide vaccine plus Poly-ICLC trials George Klein, M.D., D.Sc.* research in cancer immunology has injection site microenvironment for • Hiroshi Shiku, M.D., and Shinichi in participants with melanoma • Sacha Gnjatic, Ph.D., Icahn School Karolinska Institute, Stockholm, had a far-reaching impact on the resected stage IIB-IV* Kageyama, M.D., Mie University • Victor H. Engelhard, Ph.D., and of Medicine at Mount Sinai, New Sweden cancer field. • Craig L. Slingluff Jr., M.D., School of Medicine, Mie, Japan Craig L. Slingluff Jr., M.D., York, NY Studies on Epstein-Barr virus, Robert D. Schreiber, Ph.D.* University of Virginia Cancer University of Virginia Cancer oncogenes and tumor suppressor Washington University School of Center, Charlottesville, VA A phase I study of concomitant WT1 Center, Charlottesville, VA NY-ESO-1 and mixed bacterial vaccine genes, tumor immunology, and Medicine analog peptide and NY-ESO-1* clinical trials and immune monitoring inhibition of tumor cell growth by In partnership with the American A phase I open label, multicenter, • David O’Malley, M.D., The Ohio Phase I study of NY-ESO-1 protein + • Elke Jäger, M.D., Krankenhaus stroma cells Association for Cancer Research multi-ascending dose trial evaluating State University Wexner Medical Poly-ICLC +/- Montanide® ISA-51 Nordwest, Frankfurt, Germany In partnership with the Concern the safety, tolerability, and Center, Columbus, OH VG vaccine in patients with advanced Foundation immunogenicity of intramuscular • Paul Sabbatini, M.D., Memorial malignant melanoma recombinant NY-ESO-1 protein with Sloan Kettering Cancer Center, • Nina Bhardwaj, M.D., Ph.D., Icahn GLA-SE adjuvant in patients with New York, NY School of Medicine at Mount Sinai, unresectable or metastatic cancer New York, NY expressing NY-ESO-1 cancer • Immune Design, Seattle, WA

CANCER RESEARCH INSTITUTE 2014 ANNUAL REPORT 27 HONORING OUR

01 02 DONORS

one of the lifesaving research that CRI supports Nwould be possible without the generous financial contributions of our donors—individuals, foundations, When I went and corporations. CRI honors those donors by being “ through all the responsible and strategic about its resources, giving our supporters confidence that we will use their charities, I felt that money wisely to achieve the greatest impact possible. CRI was doing what From the thousands of individuals who make one-time donations, 03 I wanted done, to the many families who give yearly in memory of a loved one, to our trustees who give generously of both their time and money, where the majority no gift to CRI goes unappreciated. These contributions continue of the money was 04 05 to make a difference in the life of the organization. Among the many notable fundraising events of this past year spent on research. were the 27th Annual Awards Dinner, which raised a record- breaking $1.5 million, and the 2014 Through the Kitchen benefit, Penny Bolton, which raised $1.2 million for CRI’s postdoctoral fellowship Bras for a Cause program. Together, unrestricted donor contributions to CRI totaled $24.5 million in the last year.

07

01 Lauren Veronis (right) and guests, Through the Kitchen 06 Peter Coley, ING New York City Marathon 02 Will and Wandy Hoh, Through the Kitchen 07 Young Philanthropists Council Winter Soiree attendees 03 Michael Kellen, Adam Kolom, and Charles J. Hecht 08 Young Philanthropists Council Winter Soiree attendees 04 CRI trustee and golf event chair Carlos Ferrer (center) and guests 09 Bras for a Cause community fundraisers 05 Joel Paula, Scott Snyder, and friend

06 08 09 CANCER RESEARCH INSTITUTE 2014 ANNUAL REPORT 29 The Cancer Research Institute’s ability to advance important science and facilitate the development of C.R. Bard, Inc. McMullan Family Fund immunotherapies is made possible through the generous support of our donors. Acknowledgements Freda Wilkerson Bass Medical & Biological Laboratories listed here reflect contributions made to CRI between July 1, 2013, and June 30, 2014. Joanne Benedict Co., Ltd. Curtis Bergan National Association of Buffalo Biovest International Soldiers and Troopers Motorcycle Club Mr. and Mrs. James C. Blair Sebastian V. Nicastro $1,000,000+ The John and Christine Fitzgibbons Karen and Matthew Crews McCann Charitable Foundation Arnold Bortman Family Foundation Parkell, Inc. Bristol-Myers Squibb Foundation Dancing Tides Foundation Inc. Merck Mr. and Mrs. Daniel Brodsky PDT, Inc. Georgia and Don Gogel Mr. and Mrs. Victor F. Ganzi Debevoise & Plimpton LLP Morgan Stanley Smith Barney LLC Mr. and Mrs. Charles Bronfman Jane and Robert Perkinson Anna-Maria and Stephen Kellen Oliver R. Grace Charitable Dendreon Mr. and Mrs. Jacques C. Nordeman Celldex Therapeutics Vickie and Rahn Pitzer Foundation Foundation Mr. and Mrs. Glenn J. DeSimone The Kenneth T. and Eileen L. Norris Mr. and Mrs. John Chadwick Portfolio Advisors, LLC MedImmune, Inc. Marion Esser Kaufmann Foundation Mr. and Mrs. Brennan Diaz Foundation Joseph M. Cohen Verne C. Powell Sean N. Parker Foundation Mr. and Mrs. Alexander P. Lynch Thea Duell and Peter Cook Paul and Anna Oschwald Trust Corning Incorporated Mr. and Mrs. Paul E. Raether Robertson Foundation The Honorable Colleen McMahon Patrick J. Durkin Perri Peltz and Eric Ruttenberg Kimberly Coronado James A. Randel VentiRx Pharmaceuticals, Inc. and Frank V. Sica Albert Nathan Eisenberg Charitable Peregrine Pharmaceuticals, Inc. Crane Foundation, Inc. Adam J. Richter Charitable Trust Andy and Tom Mendell Foundation Trust Polo Ralph Lauren Foundation Danem Foundation The Edward John and Patricia $500K - $999K Orinoco Foundation Alixandra G. Englund Red Crane Foundation Footprints for Peace Rosenwald Foundation Cure Brain Cancer Foundation Mr. and Mrs. Andrew M. Paul Estron Chemical, Inc. Mary Ricks Connie Frank Foundation Kevin W. Sharer Mr. and Mrs. John Eckerson The Linda C. Pinkus Fund Mr. and Mrs. Carlos A. Ferrer Julian Robertson Frontier Communications Michael Charles Sharp John and Jean Eckerson Family David M. Polen Retirement Plan Finneran Family Foundation Mr. and Mrs. Steven Roth Roger and Brenda Gibson Eric P. Sheinberg Foundation Foundation Proceeds Trust Mr. and Mrs. Norman Freedman The Mortimer D. Sackler Family Foundation Mr. and Mrs. Ernest B. Smith Mr. and Mrs. Sean P. Fahey Lief D. Rosenblatt Samuel Freeman Charitable Trust Foundation, Inc. Mr. and Mrs. Jay Goldberg Sue Anne Smith Shelter Hill Foundation Jeanne and Herb Siegel Robert C. Galvin Lily Safra Estate of Victor E. Hansen Spredfast Betsy and Paul Shiverick Jane and James Stern Sophie Garafola Adolph and Ruth Schnurmacher J. Ira and Nicki Harris Mr. and Mrs. Leonard N. Stern Sharzad and Michael Targoff Estate of Carole Gardner Foundation Family Foundation The Laurence Cecil and Fay Strout Diane and Tom Tuft Mr. and Mrs. Peter A. Georgescu Edith M. Schweckendieck Trusts $100K - $499K Noreen and Fred Hassan Revocable Trust Ueberroth Family Foundation Goldman, Sachs & Co. Paul J. Sekhri Gertrude L. Hirsch Charitable Trust Mr. and Mrs. Miles M. Stuchin Concern Foundation Herman B. Golub Charitable Trust SillaJen Estate of Salvatore Corsaro Rochelle and David A. Hirsch TESARO, Inc. $10K - $49K John G. & Jean R. Gosnell The Speedwell Foundation Foundation, Inc. ThomasARTS Mr. and Mrs. Maurice J. Cunniffe Foundation, Inc. Walter & Louise Sutcliffe Leslie and Bob Dahl Agenus Estate of Nurine Hoke The Yaspan Unterberg Foundation Allen & Company, Inc. Mrs. Oliver R. Grace Foundation Innovate International Intelligence Vestar Capital Partners The Robert I. Fendrich Family Trust Green Charitable Foundation, Inc. Mr. and Mrs. Alfred Taubman Genentech, Inc. California Fund of the Hugh J. & Integration, LLC Mr. and Mrs. Jacob Vos Andersen Foundation Joyce Green Family Foundation Mr. and Mrs. Andrew K. Tsai Mr. and Mrs. George Kaufman Weatherspoon Charitable Foundation Mr. and Mrs. Oliver R. Grace Jr. Mary Gurster Estate of Zelda M. Uthe F.M. Kirby Foundation, Inc. Dr. Eva Andersson-Dubin and Donald L. King Mr. Glenn Dubin Hagedorn Fund Varian Medical Systems Foundation Joel Klein Estate of Francis R. Linden Shirley & Burt Harris Family Luc Vautmans $1,000 - $4,999 Astellas Pharma US, Inc. Heidi and Michael Kluger Anonymous (25) Harvey A. Linden Charitable Foundation Lauren and John Veronis Rose M. Badgeley Residuary Rachel Rutherford Englund Knapp AeroDyn Wind Tunnel Remainder Trust Margaret Hayman Trust VMware Foundation Charitable Trust Mr. and Mrs. David H. Koch Bill Albano The Ambrose Monell Foundation Mr. and Mrs. Philip Hempleman Mr. and Mrs. Ronald G. Weiner Estate of Ella R. Banks Steven Kroft Patrick Allare Estate of Carmen F. Patti The Hertz Corporation Estate of Elizabeth A. Weiser The Jeanne E. and Jacob A. Barkey The Ralph & Ricky Lauren Jane B. Allen Mr. and Mrs. Brian Riano Marlene Hess and James Zirin Whiting Foundation Memorial Fund Family Foundation, Inc. Allison, Inc. Sean I. Sauler Grace Humphrey Testamentary Trust Steve Wiggins Jeri Berryhill Lazard Freres & Co. LLC Alpha Delta Kappa Estate of George C. Thomas Jr. The Hurlbert Family Foundation The Blavatnik Family Foundation Dalia and Larry Leeds American Express Foundation The Wildflower Foundation Helen L. Kay Charitable Trust Bloomberg $5K - $9K Morris and Lillie Leibowitz Donald W. Ammerman James Kelly The Boisi Family Foundation Anonymous (4) Charitable Trust Mr. and Mrs. Dale P. Anderson $50K - $99K Mr. and Mrs. Kenneth G. Langone Bonbright Family Foundation Trust AbbVie Inc. Jeremy M. Levin Robert G. Andrews Mr. and Mrs. Edgar R. Berner Jo Carole and Ronald S. Lauder The Burtons Affimed Therapeutics AG The Lind Partners Angelo, Gordon & Co. Estate of Frederick J. Brand The Florence & Edgar Leslie Chalkstream Capital Group, LP James P. Allison, Ph.D. Mr. and Mrs. John Lykouretzos Apple Inc. Bristol-Myers Squibb Charitable Trust Mr. and Mrs. Alex Clain-Stefanelli Amscan Inc. Mr. and Mrs. D. Scott Mackesy Argos Therapeutics, Inc. Foundation, Inc. MacHeist.com Clayton, Dubilier & Rice, LLC Mr. and Mrs. John Bader Leslie and Thomas Maheras Sandra T. Arnett Jennifer L. Brorsen and Richard M. Meyer Marcus Revocable Trust Ann and Geoffrey O. Coley Phyllis & Stewart Bain Family Fund Mailers Haven LLC Atlas Energy Holdings DeMartini Edward N. & Margaret G. Marsh Frederic R. Coudert Foundation Robert W. Baird & Co. Evan McDonald-Stewart Operating Co., LLC Mr. and Mrs. Russell L. Carson Foundation

27th Annual Awards Dinner, Cipriani 42nd Street DONORS & SUPPORTERS DONORS Fred Davis Lee Gordon Marjorie A. Knievel Charles Millender Brenna Quinn and Sean O’Hara Solarbos Inc. Savannah de Savary Anthony Granado Richard C. Kowalski Steven Mislock Renate and Walter Rados Sotheby’s Della Calce Private Foundation, Inc. Walter Grandfield William Kremer Dr. Stephen Monroe Grace Rapinchuk Jessica Spriet Mr. and Mrs. Rutger deQuay Mr. and Mrs. Jeffrey Adam Green Amy and Ernie Kremling Montgomery County 4-H Beef Club Sanjay Rattan St. Thomas Aquinas High School Héléne Déramond and Ted Totman Jon Adam Green Lee Kuntz Dana Moran Fred Reede Baseball Mr. and Mrs. John H. Dobbins Green Mountain Coffee Roasters, Inc. Perry A. Kupietz Marya M. Moskowitz Hulda and Michael Refermat Robin Stamer John Patrick Driscoll Alexis Gregory Foundation Mr. and Mrs. David P. Kusel Jason Much Mr. and Mrs. Jonas J. Rieter Stamford Hospital DTIS LLC Mr. and Mrs. Peter Gregory La Miet Club Mr. and Mrs. Jeremy W. Mullendore Mr. and Mrs. David Riparbelli Bonnie M. and Robert J. Stapleton James Dunne Mr. and Mrs. William M. Gutowitz John and Sheila Lake Murfreesboro Medical Clinic, PA Frank E. Roberts The Honorable and Mrs. Kenneth Nancy P. Durr Mr. and Mrs. Bruce J. Haber Mr. and Mrs. Benjamin V. Lambert Nusrat Nabi Dave Robertson Memorial Fund W. Starr Kurt Dustin Russell Hackmann Konstantina Lampione Miles Nadal Max J. Roha State Metal Industries, Inc. Angela and Christian Ehemann Isabelle Hamilton Dr. and Mrs. Richard Landesman Jenks Necker Charitable Fund Mr. and Mrs. Jeffrey Rosenbluth Mary K. Steffens Foundation EisnerAmper LLP Mr. and Mrs. Lee Hanger Landmark Credit Union Sergei A. Nedospasov, Ph.D., D.Sc. Rosetta Resources, Inc. The Sternlicht Family Foundation Inc. Eric Ellenbogen Fleur and Leonard Harlan Carey F. Lathrop New York Life Insurance Company Rosson Phillips Group Patricia Stohler Steven K. Ellis The Harris Family Charitable Fund Jeffrey T. Leeds Kevin K. Nickel Rotary Club of Queensburgh, Raul J. Suarez Cancer Research Institute event, Palm Beach, FL Emarzium LLC Karen Harris Mr. and Mrs. Richard S. LeFrak Mr. and Mrs. Robert B. Nolan Durban, South Africa Estate of Myrtle B. Summers EnergyIQ Mr. and Mrs. Steven K. Harris Nina Lesavoy Stephanie and Peter Nolan Foundation Mr. and Mrs. Jonathan Roth Tantalum Pellet Co. & Employees Helen B. Esokait Trust Mr. and Mrs. William B. Harrison Andrei Levin North Carroll High School Edward Rowe Jean and Kenneth Telljohann Ann M. Bailey The Bryn Mawr Trust Company E. Joseph Evans Charitable Trust Dr. William A. Haseltine Charles and Margaret Levin Northeast Union Group Inc. Barry D. Roy Tennis League Network, LLC Bakercorp Tory Burch Dr. and Mrs. Anthony B. Evnin Marc Hassan Family Foundation Jeffrey Nuechterlein Robert Rushton Google Inc. Charitable Giving Fund of Charles Banks Mr. and Mrs. Tom Burman Benjamin Falchuk Paul Hayaux Michael S. Lewin Mr. and Mrs. Jeffrey Nusbaum The Rust Family Foundation Tides Foundation Mary R. Baque Trust Robert B. Burnett Mr. and Mrs. Thomas E. Falgout Head Family Trust Caroline Loeb Winifred K. Nyce John Salisbury Judith Tinsley Foundation, Inc. William D. Barbo Suzanne E. Burnette The Milton and Sylvia Feldman Donald B. Hebb Jr. Carol and Gary Lucido Mr. and Mrs. Gregory A. Odle Suzanne Salm Mr. and Mrs. Andrew H. Tisch Mr. and Mrs. Padrick Barrett Charles C. Butt Foundation HED, Inc. Mr. and Mrs. Pete and Jeanine Lunardi Christine Ogata Michael Scallan Supreya Tosakulwong The Barrington Foundation, Inc. C4 Sports Mr. and Mrs. Mitchell B. Feldman Renee Herzing Mr. and Mrs. Donald Lundholm Royce E. Oliver Jr. Mrs. Susan P.N. Schaller and Alain Tranchemontagne Pamela S. Barry, Ph.D., and Thomas W. The Campbell Family Louise Egdorf Fescine Beth Hickey Mr. and Mrs. Michael D. Magidson James A. Olson Mr. Richard G. Schaller Mr. and Mrs. John Trousdale Schneider, Ph.D. Mr. and Mrs. Rohn Campbell The Fisher Family Charitable Fund Mr. and Mrs. James P. Higgins Laurence and Tony Magro Once for All Trust William O. Schmale U.S. Family Foundation Inc. Jane M. Bartels Mr. and Mrs. Arthur L. Carter Kristen Kelly Fisher Mark Himelstein Chris & Melody Malachowsky Mr. and Mrs. John Orlando David N. Schrier Utility Contracting Co. Mr. and Mrs. Gerald Bartolomucci Pamela and John Casaudoumecq Eric M. Flom Deborah A. Hodes Family Foundation Ottilie Fund Schulman Family Foundation Mr. and Mrs. Jeffrey K. Valentine Sr. Basintek, LLC Castle Harlan, Inc. John A. Flood Mr. and Mrs. Paul Hoehne Mr. and Mrs. Jay Mandelbaum Darryl L. Parrish Henry C. Schulte and Virgina M. Shirley A. Van Clay Mr. and Mrs. Charlie Baynes-Reid The Cayuga Foundation Josh Ford Mr. and Mrs. Burt Hoffman Mr. and Mrs. Michael Maranto Partners Capital Investment Schulte Foundation Sharon and Cole Varvel The Sally Beatty and Robert Sawyer Dr. Jacob M. Chacko Foresters Executive Leadership Team Mr. and Mrs. William Hoh John Marino Group, LLC Seaman Family Foundation Ran Vautmans Charitable Foundation Lewis Cheney Mr. and Mrs. Thomas Franco Bruce R. Huebner Jeanne A. Markey and Gary L. Azorsky Mr. and Mrs. Kevin Payne Charles D. Sears Jan T. Vilcek, M.D., Ph.D. Robbie and Ted Beaty Mr. and Mrs. Daniel K. Clark Lucy Freund HZDG Development Department Jane Martin and Stuart Katz Pear Valley Vineyard, Inc. Usha Seth Dominique von Sivers Mr. and Mrs. Everett A. Bell Steve Cohen Jacquelyn and Stuart Friedland Capt. Scott Ingraham Mr. and Mrs. Redge A. Martin Mr. and Mrs. Jeffrey M. Peek Mr. and Mrs. William B. Shaw Robert B. Walker Susan W. Benton Steven B. Coleman Galena Biopharma Kajeen G. Irwin Martins Construction Corporation Michael Pena Mr. and Mrs. John Sheehan Mr. and Mrs. Webster U. Walker Jr. Mr. and Mrs. Jonathon Berezinski Jack Comer Neil Gallagher Deborah and Arthur Jacobson Dr. Philip Mastman Denise M. Peterson Rocky R. Sherer Barbara Walters Jeffrey Berkaw Mr. and Mrs. Richard Corey Mr. and Mrs. Paul Galvin Mr. and Mrs. Robert J. Jacobson Jr. Robert Mauer Holly Peterson Foundation Mr. and Mrs. Stephen C. Sherrill Carrie L. Walworth The Berkowitz Family Foundation Corporate Risk Solutions Sarah Belk Gambrell Mr. and Mrs. Jeff Jaenicke Nancy L. Mauro Robert L. Peterson Showin’ for a Cure Jeff Ware Berkshire Fund Mr. and Mrs. Ronald Couture Timothy Garry Purvi Janardhan Kammy J. Maxfeldt Mr. and Mrs. Theodore Peyton Aaron Shumaker The Warehouse Mr. and Mrs. Edward M. Bermas Mr. and Mrs. James R. Coyle Linda Gase Robert W. Jenkins Mr. and Mrs. David Mayman Kevin Pfau Peggy Siegal Carol and George Watral Mr. and Mrs. Philip Berney Duffy Credle Linda and Daniel Gerding Anne and Johnny Jones Lynn G. McAtee Mr. and Mrs. Regis Philbin Mr. and Mrs. Brian D. Silverman Lynne and Peter Weil Mark Berry Susan and William Crews Mr. and Mrs. Daniel Gerst Judith Jones Kate A. McKay Angela Phillips Steven Simon The Weingarten Schnitzer Foundation Mr. and Mrs. Larry D. Billen Kirk Cromer Mr. and Mrs. Jeffrey R. Gibbons Matt Jones Robert M. McKeon Mr. and Mrs. Richard Plepler Linda G. Singer Helen and Tom Welling Bloom Farms Robert Cronin Charles Gibson Kane Environmental Engineering, Inc. Michael McNicholas Jennifer and Bruce Polnicky Lois V. Smigel Julia W. Whitaker BMR Construction Management, Inc. John Crook Richards Gilbert Karuna Foundation Nelson Mead Fund Mr. and Mrs. Robert A. Posner Betty S. Smith Gerald I. White Bogatin Family Foundation Nancy and Keith Croxton Girlfriends Films, Inc. Kate’s Cure Richard Meier Foundation Andrea and Andrew Potash Cynthia Smith Jim Wiatt Mr. and Mrs. Jeffrey D. Bolton CureVac GmbH Mr. and Mrs. David Glendinning Lisa Keller Mr. and Mrs. Dennis Mejillones Beth A. Potter Mr. and Mrs. Jeffrey Q. Smith Roger Wilkie Marisa Bolton Mr. and Mrs. John R. Curtis Jr. Mr. and Mrs. Kenneth H. Globus Mr. and Mrs. Michael J. Kenig Jr. Mr. and Mrs. Martin Melson Mr. and Mrs. Robertus Prajogi Mary F. Smith Family Foundation Neil Wilson Mr. and Mrs. Oren Bramson CVS Caremark Laurie and Jeffrey Goldberger Mr. and Mrs. Richard Kerns The Sue and Eugene Mercy Jr. Julie and Paul Prestopnik Ruthanne Smith Michael Woinsky Charlotte Brenner Mr. and Mrs. Barrie M. Damson Ellen M. Golub Charitable Foundation Michael F. Klein Foundation Inc. QMT Associates, Inc. Maksim Smotritskiy The Woodworth Family Trust Nancy Brinker Charitable Foundation John Danhakl Google, Inc. Marilyn and Robert Klett Microsoft Qualcomm Lisa S. Snoddy Doug Wright Amy Bronstein Dave’s Gourmet, Inc.

CANCER RESEARCH INSTITUTE 2014 ANNUAL REPORT 33 Dorothy Wrigley Mr. and Mrs. Gerald Becker Mr. and Mrs. Erik Counter Scott Gehsmann Todd Hughes Mr. and Mrs. Robert C. Lake Brian Murphy Mr. and Mrs. John M. Rowe Stephen Yegelwel Gentry Beckmann Mr. and Mrs. Kelly Courter Barbara B. Gentry June and Tim Hunt Darren Lam MUTI Mr. and Mrs. Mony Rueven YoYoJam Inc. Christina and Todd Beringer Mr. and Mrs. Albert Covelli Jeffrey L. Gentry Robert C. Hunter Elizabeth Lancaster Suman Mysore Richard Saccone Raymond Yu Tom Biancardi Lisa Roberts Cowell Kenneth A. Gill Illinois Tool Works Foundation Mr. and Mrs. Charles Langdon Lily and Rodney Nahama Dr. Kirk Saddler Mr. and Mrs. Will Zeckendorf Domenick Bianco Maury Cralle Girls Raised in the South Naoko Imai Mark Larrimore Mr. and Mrs. Uday R. Naik Mr. and Mrs. Geronimo J. Sanchez Ralph E. Zerweck Frances and James Bittner Clark Crawford Joan E. Godwin Dr. and Mrs. Richard Imbruce Gloria L. LeBlanc Nationwide Credit Corporation SanDisk Corporation Mr. and Mrs. Jeffrey Zucker The Boeing Company Michael Croslyn Deidra Gold In His Image Day Spa, LLC Mr. and Mrs. Alan J. Lebow Jamie Naylor Mr. and Mrs. George Sarner Laura Bollman Daniel B. Cullen Marisol Gonzalez De Cosio Bill Indelicato Mr. and Mrs. Gregory P. Lee Brian Neace Mr. and Mrs. Raymond Schansman $500 - $999 Mr. and Mrs. Brian Boone Randi and Roger Cunningham Mr. and Mrs. Adam Goodman Investigative Sciences Thierry J. Lefever Nektar Therapeutics Petra Schindler Carter Anonymous (19) Paul Boruta Jennifer Curtis-Maury Mr. and Mrs. Ronald B. Gordon Nassar Jabour Mr. and Mrs. Marvin E. Lesser Mr. and Mrs. David Niehaus Mark Schlau 1-800-flowers.com, Inc. Kellye Bowers Evelyn J. Cusack Paula Gorlitz and Steven Zuckerman Dr. and Mrs. Theodore J. Jacobs Ethan M. Levine Robert Northington Shirley Schmelzer Kedar Abhyankar John N. Brady Sharon Dahlhaus R. Raymond Gorospe The Jaffe Family Foundation Richard Levine Nuveen Investments, Inc. Arlyn Schneider Acadian Asset Management LLC Joseph F. Brady Linda Daines Andrew Gould Viju James Mr. and Mrs. Arthur Levitt Jr. Nikolas Oka Karen and Henry Schneider Kenneth Adams Mr. and Mrs. Kevin Brennan Joni Daniel Natalie Grace and Jacques Dejoux George J. Jarvis Grant Lewis The Om Center for Yoga & Massage Judith Schwartz Anne and Richard Adler Mr. and Mrs. Michael Brennan Bruce S. Darringer Gravy’s Bar & Grill Bunny and Ryan Jeffries Lincoln Financial Foundation Jacob Oresky Marilyn Schwartz Adobe Systems Incorporated Stuart Bretschneider Alberta Davis Paul E. Gray Jr. Cory Jensen Lion Biotechnologies, Inc. Adam C. Orfgen Jane Scriptunas Aduro BioTech, Inc. Warren K. Brewer Karen A. Davis Anthony J. Greco Arthur H. Jerbert Jr. Brian Lister Oswego Panther Soccer Club Ashish Sehgal Advanced Research Systems, Inc. Laura Brown John Delaplane Richard Green JMC Capital Partners Darlene Helms Lopez Vernon Pankonin Mr. and Mrs. Richard Seidenstein Sameer Agrawal Mr. and Mrs. Paul A. Brown Nicole DeLeon Christopher M. Grubert James R. Johnson Dr. Dorothy L. Lord Todd A. Papa Kathleen and William Seider Airtime Paragliding Jost Brunner Delta Kits, Inc. John C. Gunnin Mr. and Mrs. Lewis O. Johnson Katherine M. Lorenz Ann and James Parker Joel P. Selden Francis Albert Carla J. Buck Mr. and Mrs. Diamond Amit K. Gupta Johnson & Johnson Daniel M. Loss Partners Healthcare Mr. and Mrs. Walter D. Seward Corinne E. Alexander Dr. Marcia B. Bull Mr. and Mrs. Michael D. Dillon Mr. and Mrs. Paul Haack Jolliff Ranch Kurt Louis Mike R. Paskovich Bruce Shaffer Amy Alspach Bundle Of Holding Mr. and Mrs. David A. Divine Adeline Haggerty Cynthia Lynn Jones Margaret Loveless Patricia Paula Jonah Shapiro American Express Company Richard Busch Gabe Donohoe Margaret H. Hamachek Hemant Joshi Gina Luppino Michael Perkins Rebecca Sharpe and Peter Bruck Tom Ampeliotis Mary Callaway Daniel T. Dubbeld Jacquelyn A. Hank and Timothy J. Jerry Kanter Joel MacIntosh Pharmaceutical Research and Michael Shelby Amplifi Commerce, LLC Jeffrey Calvello Mr. and Mrs. Lance Dunn Muldowney Mr. and Mrs. Howard Kaye Mr. and Mrs. Jonathan C. Maldon Manufacturers of America Mr. and Mrs. Robert Sheldon Garth Ancier Mr. and Mrs. Liborio Campo Stacey Durand Hank Lane Music & Productions Russell Kempf Jerome P. Malinay Pine Hollows Charity Fund Inc. Mr. and Mrs. Paul M. Sherer Joyce J. Andersen Larry Cantor Linda Edelcup Mr. and Mrs. Robert Hanscom Mr. and Mrs. Nick Kepler Mass Relevance Olga and Pat Piro Jeffrey R. Sherman Kristine E. Anderson The J. Gregory Carl Charitable Fund Joel T. Edman G. Felda and Dena Hardymon Joshua Kesselman Ann F. Mather Deborah A. Platt Mr. and Mrs. Leonard Sherman Terrill A. Andrews Brian Carr Marielle Emit Mr. and Mrs. Leonard Harrison Leroy Kim Binu K. Mathew Mary Polak and Lloyd Sweet Michael B. Shields Annapolis to Bermuda Race Frank H. Carr Epic Wines Victor Hatami Betsy and Rob King Matthew Family Charitable Eric Polhamus Shomos Family Foundation Organization & Bacon Sails Company Randal L. Carter Dr. John R. Etherton Mr. and Mrs. Michael Haus Jean King and Stuart Appelbaum Foundation Trust Shirley Ponsart Arcus Technology, Inc. Saundra and Jim Castleberry Faye M. Etter Mr. and Mrs. Frank Heflin Lenore Klein John Mauro Ronnie N. and William A. Potter and Tiffany Howard Express Employment Professionals Janet and George Heilmeier David J. Kleindienst Francis McCall Stephen C. Pracht Susan Crow and Tony Bennett Erik Arnetz at Through the Kitchen Scott W. Arnone Mr. and Mrs. Chris Cesar F & K Designs LLC Paul C. Helmick Corporation Alex Kline Judith McGrath Jason Preslar John F. Aronson Shari and Daniel Charous F and MWL Enterprises Inc. Linda J. Henderson Samantha L. Knapik Sean A. McMains Marvin Price Mr. and Mrs. James Aselta Chevron Humankind William B. Fagan Mr. and Mrs. Michael J. Herbst David Knievel Derek McTyier Ryan Prosser Stefan Aumack Mr. and Mrs. Clifton Chilcoat Mary Farrell Marcia K. Herrera Mark N. Koch Sanjay Melwani Adam Proujansky Armond Avanes Chippewa Lake Community Church Pat Feezor Rita Hertenstein Mr. and Mrs. Jeffrey S. Kochel Mr. and Mrs. Manuel Mendes Mr. and Mrs. Joseph P. Quinlan Mr. and Mrs. Joseph Azara Dr. and Mrs. Joonun Choi Fern & Fox Goods Stephen E. Herzog Mr. and Mrs. Monroe A. Kohn Mr. and Mrs. Blaine L. Mercado Leesa S. Railsback Marielle Balz Chronicle Books Debbie and Paul Feuerborn Themis P. Hios Tetsuaki Kokura Andrew C. Merrill Beatrice Redd Matthew Banal Robert Cipoletti Julie Finley Amanda and Jonathan Hirshon Mr. and Mrs. Robert Kooiman MHRC, LLC Kristin Reid Curtis K. Barker Cisco Fitzgerald-Gates Family Trust Michelle L. Hoesly Mr. and Mrs. Werner H. Kramarsky Scott Michell Mr. and Mrs. Nicholas Reynolds Cody Barrington Mr. and Mrs. Art Clark Waldo Freeman Mr. and Mrs. John Hoevener Jeffrey Kramer Angela and Ryan Miller Virginia Rice The Bartholow Marital Trust R. Michael Clark Mr. and Mrs. Bob Fritz Richard A. Hoffman Tessa Kramer Mr. and Mrs. Mark A. Mitchell Mr. and Mrs. Andrew Richards Brian L. Bartlett Leslie Clevenger Patty Frykberg Mr. and Mrs. Justin C. Holder Mr. and Mrs. Ron Kripalani Sharon Montague Col. and Mrs. James L. Roach Mary L. Bartlett Jimmy Clidaras Fulton Bank of New Jersey Honeywell International Sriram Krishnan Anne B. and Allen Moore III Jason Roberts Mr. and Mrs. Neil Bayer Coatpro Steve Gable Philip Hood Doris Krys Dr. and Mrs. Malcolm Moore Sarah M. Robson and Melanie Bearden Jacki and Robert Colburn Rami Gabriel John R. Howard Jr. Mr. and Mrs. Wayne R. Kubick Marcus Mordachini Stephen Harrison William D. Beattie Neil Cole Gorang Gandhi Lori L. Hoyt Mr. and Mrs. Kevin Kuntz Charlotte Moss and Barry Friedberg RollGiving Daniel Beaty Andrea Coleman Catherine C. Gardner Ruth E. Hubbard Mark Kwan Mr. and Mrs. Michael E. Mozina James Rosenthal Norman Beazer Mr. and Mrs. Bradley L. Coley Jr. Wayne Gehrt Laurie Hughes Jeffrey LaHoste Dr. Alfred Muller Matteo Rossi Airtime Cafe, Lauterbrunnen Mr. and Mrs. Chuck Benwitt Annette L. Chai Mr. and Mrs. Doug Dembowski Walter Fisch Randi Aitken The Berkley Group, Inc. Alfonso Chang James Dennis Mr. and Mrs. David Fischer Dr. and Mr. Susan B. Albaugh Charles J. Bernard Olivia Chau Gino A. DePalma Shirley S. Fisher Mr. and Mrs. Louis Alfero Mr. and Mrs. Anthony Bernardi Beth Ann Chiles Mr. and Mrs. Kevin Dersch Matthew Flager Mr. and Mrs. Shane Allender Mr. and Mrs. Barry S. Bernstein Neeraj Chouhan Jon Deutsch Fleet Hill Mr. and Mrs. Lawrence M. Alleva Cheryl B. Besterman Lyle M. Christensen Richard Devine Fletcher, Heald & Hildreth, P.L.C. AllianceBernstein Jonathan Bete James Christopoulos Mr. and Mrs. David Diamond Tyler Folck AMAT Community The BGE Mr. and Mrs. Marc Cinque Jenea Diamond Patrick J. Foran American Saturated Felt Kristen Bird Cindy Cinquino Frank DiGiacomo Gary H. Forman Shaza Andersen Nicole Bisson Robert Clayton Bruce D. Dixon Edward Fornataro Elizabeth Anderson Ronald Blazek Mark R. Claywell DoctorDirectory.com, Inc. Alan W. Forrest Mr. and Mrs. Mark E. Anderson Audrey Block Adam Clemens Elizabeth A. Dolezal Franklin Display Group Larry Andreassen Chantal Block Lindsey and Evan Cohen John Donahoe Christie L. Fraser John Anzalone Patrick Block Antonio Cokovski Donahue & Horrow Fredericksburg Chapter #29 ARCO/Murray Kyle Bohan Dr. and Mrs. Bobby M. Collins Mr. and Mrs. Mark Donegan Order of Eastern Star Arm, Inc. Mr. and Mrs. Andrew Boldt Frances S. Combe Mr. and Mrs. David L. Dorenfeld Mr. and Mrs. Howard S. Friedman Aalia Arshad Bonanza Beverage Company Judith Comroe Mr. and Mrs. Jay L. Doty Stephen Gaddy Timothy Arthur Greg Borley Congregation Beth Torah Mr. and Mrs. Alexander H. Dow Mark Gallogly Arash Asadi Mr. and Mrs. Michael J. Boyd Executive Committee Mr. and Mrs. Arthur V. Doyle Esther Gamez Billy Ash Mr. and Mrs. Royce Bradford Peter H. Connelly Ruta G. Dudenas Alizeh Gangji CRI trustee Bob Dahl (right) with winning foursome members at the 19th Annual Golf Challenge, Sebonack Golf Club Rita Ash Matt Brady Conveyor Sales Company Mr. and Mrs. Michael J. Dunn The Ron and Debbie Garrow Gift Fund Mr. and Mrs. Steven S. Ausnit Harry N. Bragg John Coonly Paul Dunn Mr. and Mrs. N. Pierre Gaston Mr. and Mrs. James B. Avery Michelle R. Brasseur Cece Cord Margaret Durney Gastroenterology Consultants, P.C. Allan Warton AXIS Insurance - E&S Property Adam E. Bremberger Rev. Sara Cory and Rt. Rev. Thomas Mr. and Mrs. Stuart Dutter Mr. and Mrs. Todd P. Geismann Mr. and Mrs. Richard T. Short Eric Stiff Mr. and Mrs. Edward Wax John S. Bach Scott Brennan Stephen L. Cotter Mr. and Mrs. Douglas Dutton General Reinsurance Corporation Chad Shuskey Megan Strauss Dorothy J. Wehlage Brenda K. Bacon Mr. and Mrs. Jason R. Bretz Jane and Stephen Coutts Karen C. Dyer Rebecca L. Gentry Mr. and Mrs. David T. Siegel Mr. and Mrs. Jan Suwinski Linda A. Wells Stephanie A. Badanes Beverly G. Brodioi Kerrie I. Cozic Eastern Performance Rosemarie Genualdi Mr. and Mrs. John Siffert Shawn Tabin Kent Werth Dr. Susan E. Baer and Mr. and Mrs. Michael C. Brooks Kathleen Crane Peter Edge Mr. and Mrs. Scott M. Gerard Siler & Ingber, LLP Tara Tal and Aylon Brandwein Robert P. West Living Trust Mr. Bruce Thornburg Keith W. Brown Dr. and Mrs. Neil Crellin Mr. and Mrs. Thomas C. Edwards Ilias Gerontidis James W. Silver Mark Talluto West Michigan Academy of Sandra Bailey Kathleen E. Brown-Hall Mr. and Mrs. Robert Crisalli Christina El Moussa Mr. and Mrs. Vishal Ghiya Dr. and Mrs. Paul M. Simic Mr. and Mrs. Kok Chor Tan Arts & Academics Leila Balali Domenique and Jonathan Buck Andrea Cronin Electro Rent Corporation Mr. and Mrs. Umberto F. Gianola Erin Simmons Ryan Taylor Mr. and Mrs. Gordon J. White Susan M. Baldini Terri L. Buckley Bruce M. Crowell Mr. and Mrs. Alan G. Ellis Mr. and Mrs. Charles Gillis Simple Pleasures Rubber Stamps Robert Teigman Stewart Wilson Julia Bailin Estate of Anne Luise Buerger Gail Cruz Mr. and Mrs. W.J. Emerson C.W. Gilluly & Such, Inc. Todd Testerman Jytte Winslow-Mandle Todd Baldree BuildASign.com Grace Cruz Environmental Service Girl Scout Troop 824 Anthony Singer Mr. and Mrs. Ronald A. Thalmann Edith Wolfe Mr. and Mrs. Joseph Bank Patricia Burkley Katherine L. Cucco Laboratories, Inc. Mr. and Mrs. John Giumarra SiteSaver/Penda Corporation Jorgen Thelin Sandra Wolin-Bromley Florence Barad Alexander C. Burnside Donald C. Curtin Richard A. Enz Major P. Gladden Rorie and Edward Skei Michael E. Tiffany Mr. and Mrs. Ronald G. Woll Josh Barg Leslie Byelas CVAR Drivers and Friends Equifax Foundation Elliott Glass Scott Sklar Trail King Industries, Inc. Dr. and Mrs. Jerry D. Wright Mr. and Mrs. Jeffrey C. Barnhill The C.A. Cushing Charitable Gift Fund Mr. and Mrs. William M. Czarnowski ESAC, Inc. Michael Glickstein John R. Slosar Julie and James Trant Mr. and Mrs. Thomas M. Yamin Barrett Glick & Associates Mr. and Mrs. Robert A. Calder Jerome A. Dabrowski Michael Faccioli Go Go Gatsby Designs LLC Daniel A. Smith Mr. and Mrs. Jeff Travisano Vladislav Yasevich Lois I. Barthel Clark Callander Jason J. DaCosta Dr. and Mrs. Angelo Falcone Laurence Goldfein Carolyn and Don Smith Triad Racing Technologies, LLC Jane and Ronald Zimmerman Ellen Baum Mr. and Mrs. Jon S. Canale Dalby, Wendland & Co., P.C. Lillian Farrell Scott Goldman Ellen and James Smith Trim-Rite Foods / Rantoul Foods Tricia Zimmerman Richard Bavier James Canavan Louis D’Ambrosio Anthony D. Fawver Mr. and Mrs. John K. Goodman Shirley C. Smith Charitable Foundation Judy Tullie Jane Zimmy and Ronald M. Neumann Mr. and Mrs. Burton Beam Dorothy Carder Marla S. Daniels Faze 4 Orchestras A. Gordon Mr. and Mrs. Jonathan Sokoloff Mr. and Mrs. Allen Turk Howard S. Zinn Mr. and Mrs. Kevin Beausoleil Dr. and Mrs. John Carino Mr. and Mrs. Rodger D. Daniels Bruce Feffer Peter Goyne Michael Spitzer Cecile M. Turnbull Mr. and Mrs. James P. Becker Delna Carruthers Andrew C. Dawson Alexis Feldman John Grady Mr. and Mrs. Patrick St. Romain UBS John C. Begley Mr. and Mrs. Gregg Carville Robin A. De Rosa Dana Feldman John Gray The State Bank of Texas Suzanne and Donald van der Kolk $250 - $499 Jack Belch Mr. and Mrs. Norman R. Cash Mr. Andrew A. Debenedictis Nancy Feller Helen A. Green Mr. and Mrs. Richard M. Steinberg VarcoMac Electrical Construction Co. Anonymous (9) Deborah Belcher Matthew D. Casner Mr. and Mrs. David S. Decker Kate Fermoile Mark Greenbaum Dr. and Mrs. Rishon Stemer Veranda Beach Mr. and Mrs. Todd Abram Mike Bell Casto Travel - San Francisco John Deckert Beth Ferrell Alyssa Greenberg Mr. and Mrs. James Stenson Adam Vitarello Christian Adams Renate Belville Catholic Family Insurance Services Decorative Rock Sales, LLC Mr. and Mrs. Richard R. Fetterman Mr. and Mrs. Wallace D. Gregory Jr. Mr. and Mrs. Allan Stern John Vogel Judith F. Aduddell Benchmark Consulting Services, LLC Tara C. Cavanagh Tony DeCrosta Jennifer Field George Griset The Sternbergh Foundation Nicolas Von Der Schulenburg Jean E. Aeschliman Mr. and Mrs. Donald E. Benkeser Certain Affinity Joseph Del Vecchio Carol J. Finney Mr. and Mrs. Ron Grizzard Sterndrive Engineering, Inc. Jason L. Walker AIMC, LLC

CANCER RESEARCH INSTITUTE 2014 ANNUAL REPORT 37 Susan M. Gudmundson Stephen Imperato Mr. and Mrs. Lester Lai Kallie Marano Andrew W. Morrison Amrat N. Patel David M. Rappaport Melissa A. Schmitt Gumahad Family Gift Fund Eugene Interlandi Edward C. Lally Nicholas Marchi Dr. and Mrs. Michael Moses Dhanashri Patil Kristen Rathfelder Mr. and Mrs. Jon C. Schmitz Yujie Guo Theodore A. Irra Matthew LaManna Alim A. Maredia Mount Hope Trucking Company Andrew T. Patsiner Jenny Ravenscroft Mr. and Mrs. Theodore Schnitzer Mr. and Mrs. Walter Guy Izzo & Son Country Gardens LLC Thomas Lampert Michael F. Marek Naomi Moy David J. Paul Edmund Reck Tim Schoeck Mr. and Mrs. Matthew Haies Sherri Jackson Jeremy M. Landman Brett Martin A.J. Muldoon Patrick Payne Recover Painting Richard E. Schorse Eugene Hall Sandra J. Jacobson Peter Lane M. Jean Martin Lilac Muller Mr. and Mrs. Scott H. Pease Mary Y. Redman Mr. and Mrs. Michael J. Schreiner Vicki L. Hall Renee Jaffess lashavingsoap.com James Marzolino Patrick J. Mulrooney Andreas Pecher Mr. and Mrs. Daren V. Reid Barbara Schuette Janet L. Halla Martin Janis Katelyn Lau Mark Mascia Mr. and Mrs. Jignesh Naik Norma and Jerry Perlman Mr. and Mrs. Jared Reilly Mr. and Mrs. Kenneth Schultz Jeremy Halperin Janklow Foundation Mr. and Mrs. Frank Lavorato Renny A. Maslow Annette Nasif Dr. and Mrs. Bruce Perry Mary Ann Reinhard John F. Scolio Yasuhiko Hamada JLK Rosenberger, LLP Mr. and Mrs. Wilson S. Leach Jamie Mason and Paul Stagg Elaine Neely Derold F. Perry Nancy Releford Ursula Searcy Mr. and Mrs. John A. Hamilton Cheryl Johnson Lisa A. Learman Mr. and Mrs. Jari Mattila Craig E. Nelson Jarel Perullo Mr. and Mrs. Edward R. Renicker Martin Sechan Bonnie Hammer Mr. and Mrs. Keith Johnson Christopher Learned Jeffrey S. May Mr. and Mrs. James G. Nelson Allison Peterman Resource One International, LLC Tom Seclow L. Karen Hammer Valerie A. Johnston Mr. and Mrs. Thomas M. Lebeau Mr. and Mrs. Danny McCall Karen R. Nelson Pfizer Foundation Dr. Debra Ressler Greg Sedlock David Harrison Hubert Joly Hoa T. Le-Resnick Britt and Sean McDonnell Ellen G. Newman Claire M. Phillips Kenneth J. Revis Segal Consulting Brent A. Hart Jessica Jones Michael D. Lesher Victor McFadden Linda Newman Heather M. Phillips Rex Energy Operating Corp. George H. Sellers Greg Hart Julie L. Jones Michael S. Lesser Hugh McGaughy Patricia Newman Pinckney Community Schools Dale C. Rezny Septa Human Resources Willard L. Hawkins Jr. Preston Jones Paul Levesque Jane McLagan Philip Nimmo Pinnacle Property Solutions, LLC Ira Rhea, M.D. Zig Serafin Martha M. Haywood Stephen Jones Mr. and Mrs. Robert S. Levy Ciara McMahon Howard Nizewitz Dr. and Mrs. David Pitel Christopher Richmond Ralph Serpico Steven J. Hecker Victor Jongeneel, Ph.D. Mr. and Mrs. Mark H. Licht Robert C. Meade Jr. Deborah Norville and Karl G. Wellner Dr. and Mrs. Robert L. Planksy Anna Roberts Craig Setera David Heller Arleen S. Kagan Hilary Lindahl Mr. and Mrs. Steven A. Mecca John Nowak Mr. and Mrs. Richard Plese John Roland Roberts Mr. and Mrs. Saleh Shahrabani Mr. and Mrs. Lawrence Heller Dr. Michael Kahn Matthew Lindblom Rajeshwari Medam Gail Nyari-Lazzaro Mr. and Mrs. Robert Pompei Dr. Andrew Robison Reva Sharma Paul T. Hempel Jess J. Kajiwara Peter A. Lindley Ada Meloy Dr. and Mrs. Craig Olin David Portnoy Mr. and Mrs. Jeremy Rochell Mary M. Sheehy Elizabeth Herold Kaplan Fox and Kilsheimer LLP Mr. and Mrs. Bruce Lindquist Mr. and Mrs. Douglas I. Melson Sandra Olson Linda Portnoy John C. Rockwell Josh Sheets Mr. and Mrs. Allen Herskowitz Peter S. Kaplan Richard Lipsky Samuel Melton One to One MD, P.A. Aaron Posluns George C. Roeth Paul Shelton Michael Hess Timothy R. Karcher Jacqueline Liu Mr. and Mrs. Simon Mencher Jon Oringer Dr. Matthew H. Power Andrew Rogers Dr. and Mr. Robyn Shepardson HFO Investment Real Estate Mr. and Mrs. Mark Kavanagh Dr. Stephen Liu Mentor Graphics Foundation Maxwell D. Osborne Richard A. Powers Mr. and Mrs. David J. Rosso Mr. and Mrs. Jesse Shereff Janet K. Hise Patrick P. Kaylor Dominique Lock Wah Hoon Renea Mertens Melissa Ostroff John V. Pridjian Dr. and Mrs. Guillermo J. Rozas Hiroshi Shiku, M.D. Terri L. Hodge Keenan, Hopkins, Suder and Loewy Law Firm P.C. METCOR Ltd. Nestor Pacheco Mr. and Mrs. Alfred J. Prince Bernard M. Rupe Jeffrey Shore Dr. Alexis G. Hoen Stowell Contractors, Inc. Jessica London Meteorix Justin A. Pagano The Progressive Insurance Foundation Kevin Russell The Shumway Foundation Andrew Hoffman Lynette Kelley Lone Star Transportation Arthur N. Michell Pang Prudential Foundation Kristin Ruthberg Mr. and Mrs. Joseph Sidari Leca J. Holder Kevin A. Kendall Long & Associates, AIA, Inc. Midfirst Bank Rick H. Para Taylor Pruisner Michael Salsa Donald Siegelaub Revocable Bradley W. Holdridge Patrick Kennedy Mark E. Longworth Midwest Industrial Metals Corp Inc. Kate Parker Demi Pysh Lawrence E. Samelson, M.D. Trust Agreement Edna Jo Hole Tom Kennedy Zen C. Lu Military Sealift Command Combat Mr. and Mrs. James E. Parrish Mr. and Mrs. Edward I. Rabin Stacy Sanchez Lisa Siegman Holland Meadows Golf Course Patricia K. Key Mr. and Mrs. Richard M. Lucas Logistics Force Mark Parsons Eric S. Radford Scott Sands Brendan J. Sihksnel Grace D. Holt Keystone Clearwater Solutions Mr. and Mrs. John S. Luckstone Gary R. Miller Michael Pashkow Estate of Aspasia Radoumis Jane Sapery Dean Simcoe Ben Holzemer Robert Kiely Richard Lujan Mr. and Mrs. Glenn A. Miller Brian A. Pasquinelli Paul Rago and David Small Christina Scannapieco Mr. and Mrs. Gerald Simnacher Sandra Horbach Richard KillKelley Gail Lund Vicky Minneti Maria Rodriguez Pastor Mr. and Mrs. Glenn Rankin Heather R. Schank Mr. and Mrs. John D. Sipes Mr. and Mrs. Michael G. Horner Kimmel & Kimmel, LLC Tyler Lund Mr. and Mrs. Harold S. Minoff Steve Host Theresa King Michael Lynton Elayne and Barry Mischna The Wallace and Janice Houchin Jill R. Kinney Lana Lyon Bismruta Misra and Bill Douglass 2013 Marine Corps Marathon Team CRI members gather for a shared dinner on the eve of the event Family Trust Adrial Kirchen Mr. and Mrs. Ronald Lyslo Kevin A. Mistry Dr. and Mrs. Alan Houghton Cameron Klinger M.A. Primary & Urgent Care Mr. and Mrs. Larry Mitchell Mr. and Mrs. Billy Howington Roger M. Kohler Edward Ma Peter B. Mitchell Sharon E. Hoyt Terri Kouba Jacqueline MacDonald Rita Mochel Maojen Hsu Diane G. Kranz Faith B. Mackay Richard Moffie Dr. Douglas E. Hughes Mr. and Mrs. Harold R. Krivins Mr. and Mrs. David Madson Mr. and Mrs. Jeff Montague Hull & Associates, Inc. Arnold Kuenn Vivian Maese and William Bannon Adelina M. Moore Hon. and Mrs. Russell L. Humphrey Dmitry V. Kuprash, Ph.D. Anneliese Malewicz Deborah L. Moore Sarah Hunter Mr. and Mrs. Brad R. Kussy Victoria J. Malmgren John Moreno Eric R. Hwang Bobby Labonte Srinivas Mandadapu M. Carol Morgan Illinois Education Association Mr. and Mrs. Bob Laemle James J. Manning Mr. and Mrs. Paul Morken Staff Organization Jason M. Lai Marlene S. Manning Jo Morris Hamza Sirag Sarah H. Toas World United LLC Brett Frykberg Community Fundraisers Ryan Gerber Portfolio Advisors Dr. and Mrs. Ian K. Slepian Leslie Toepfer and Charles J. Hecht Joyce Worthington Naoko Imai Team CRI allowed friends, families, Mark Godsey Devin Price Christine Balko Slywotzky Ronald A. Tornow Kendall Wrigley Peter Bradley Mitchell and companies to raise funds together Gravy’s Bar & Grill Renee Price Small Planet Foods Toyota Financial Services J. Wu James Nunan in their communities in fiscal year Lydia Greer Tucker Price Robert H. Smith Toyota Motor Sales Tsae Wu William Pacheco 2014. Nikki Grimm Rachael Quick Judilyn L. Somera Dr. and Mrs. Phillips B. Trautman Mr. and Mrs. Michael C. Wyum Shruti Rao Donald Guernsey Jr. R Zeltzer Sugi H. Sorensen Travelers Community Connections Yufen Yang Fred Reede ACIR Isaac Guerrero The Right Hand of Doom Mr. and Mrs. Marco L. Spadacenta Kenneth M. Travis Yared Yawand-Wossen Danielle Ruthberg Alcatraz Swim 2014 Sarah Gunter Sherriff Robert John Spano Thomas S. Trovato Joel M. Yesley Kristin Ruthberg Saad Ali Robert G. Guthrie Claire Rosenstein Christine Speare Kuang Liang Tsai Janel A. York Evelyn Alton David Hadder RubberVoltz Modded Minecraft Server Sharon Spears James B. Tucker Liana E. Young 2014 NYC Half Amscan Inc. Payton Heimbach Joan Ryan Specialty Tile Products Mr. and Mrs. Jeffrey Tucker Lesley K. Yu Michael Billotti Asil Fights Cancer Holland Meadows Golf Course Emma Saunders Mr. and Mrs. Irwin Sperber Peter J. Tvarkunas Oliver Z. Yu Timothy Collins Gina Belka Ethan Holmes Tim Schoeck Ramona Spiegel TVHS, Audiology & Speech Mr. and Mrs. Sunny Yum Torz Dallison Karl Belka Jeff Horn Mara Sedlins Norman Spieler Pathology Svc. Leora Zach and Elias Youssef Nicole DeLeon Caron Bevard and Giovanni Jones Illinois Education Association Sarah Helene Sharp Mr. and Mrs. Joseph M. Spillane Jr. Judith A. Udell Zachys Wine and Liquor Inc. Jenea Diamond Andrew Bloom Staff Organization Colin Sheehan Vera K. Sprague United Technologies Charity Zadok Jewelers Angelo Giordano Penny Bolton In His Image Day Spa, LLC Showin’ for a Cure John R. Squier Trust Acct. Dr. Virginia A. Zakian Andrew Gould Janara Bostick Infinite Continues Sue Anne Smith St. Catherine Parish University of Florida’s Honors Mr. and Mrs. Richard Zappala Forbes Huang Chris Bowman Simon Ingold Will Smith Mr. and Mrs. Murray E. Stadtmauer Without Borders Mr. and Mrs. Nick J. Zarvos Judith Jones Jessica Bowman Ironman Foundation, Inc. Erika Spitzer and Zach Friedland Lee I. Stahl Stanley Urasaki Jessica Kalish Steve Bradford Robert Jenkins Christina Stern George C. Stamatelatos Utheverse, Inc. Endurance Events Marilynn Kaufmann The Allegra Levy Brooks Jordan Jones Alex Stolle Eric B. Steel Mr. and Mrs. Robert H. Vaden In FY2014, Team CRI helped raise Joshua Kushner Revocable Trust Kevin Josephs Caroline Stolle Mr. and Mrs. Aaron Steimle Patrick C. Valenti funds for CRI by participating in the Andy Lange Michael Brown Dasha Klyachko Edward Stolle Dr. and Mrs. Charles R. Steinberg Nancy Van Tuyle following endurance events. Lana Lee Carla Buck Charles Kukes Kevin Stolle Michael J. Steiner Lucas C. VanDeWiele John Lee Mr. Paul W. Camarda and Family Kustoms for a Cure Tricia Stolle Sherry S. Steiner Mr. and Mrs. Daniel O. Vanwormer 2013 Marine Corps Marathon Jennifer Marcus Cancer Wilderness Warriors Richard Landesman Studio Twelve Hair Designers LLC Hillary Stern Mr. adn Mrs. Otto J. Vitale Diane Baker Amanda Mathieson Brian Carruthers Patricia Laury Jeff Takeover Daniel F. Sterne Vor Vudthithamrong Richard Bavier Elaine Petit Pooja Chandwani Cassandra Lee Matos Team Brown Steven M. Stites Victoria Wagner Mike Bell Robert Reustle Kate Claas and Mark Goldman Jeanine Lizotte Travelers Bond & Financial Products Mr. and Mrs. Jonathan Stockdill Yichun Waltzer Sean Burns Lilian Shepherd Julianne Coleman Katie Lopez Bill Tritsch Joseph E. Stockwell Jr. Rebecca P. Ward Alexander Coven Frank Simo Steven Coleman Zach Martinez Carol Tritsch Ashley Stokes Mr. and Mrs. Jeffrey B. Warner Jodi Cull-Host Elizabeth Stevenson Chris Conrad Carson McBain Christine Tritsch Carol S. Sullivan Warrant Officer Staff Course 14-F02 Erica Curi Lana Sze Anna Cotton Tammy McGowan Nikki Tritsch Kathryn Sullivan Peter Watson Neal Dennison Marian and David Courtenay Megan McLees Utherverse, Inc. Mr. and Mrs. Leo J. Sweeney Justin Webb Erin Dreux 2014 TD Five Boro Bike Tour John Crook David Min Andrea Vorpahl David Swensen Dennis Weiss Toni Erwin Susan Berkley Mariely Crowne Lisa Miragliuolo Hayden Wendel Robert J. Taetsch Emily Wellikoff Greg Hart Renee Berman Cruising for a Cure Montgomery County 4-H Beef Club Emily Wiggins Mr. and Mrs. Aaron Tag Stephen A. Wellman Michael Gilroy Neal Muldoon Ewing Williams Alex Kline Whitney Darden David Courtenay, with his wife, Marian, made an Haruyuki Takaki Mr. and Mrs. Geoff Whisler Melissa Knievel-Natanson Paul McDowall Ethan Davis Erin Norris Sarah Winkler 800km trek throughout Spain, raising nearly $7,000 Scott W. Talbert Michael W. White Dana Larson Gregory Robinson Tess Doyle Heather Okenka Dane Wray for the Cancer Research Institute Diane Tannenwald and Jim Grishaw Charles Wiegold Brian Lister Daniel Schneider Lucas Durney John Okenka YoYoJam Inc. Tennyson Family Foundation Dr. Carmen S. Wilson Jason Natanson Luc Vautmans Chad Eby Catherine Orr Zachys Wine and Liquor Inc. Rebecca L. Terlecki Mr. and Mrs. Kevin Wilson Jackie O’Brien Ran Vautmans Express Employment Professionals Barbara O’Shaughnessy Christopher Terrasse Michelle Wilson Gesine Prado Walter Weil Robert Farrell Matt O’Shaughnessy Athalie A. Terry Wilson Construction Co. Bret Salmons Yared Yawand-Wossen Andrea Ferdinand Matthew Osiecki Mr. and Mrs. Thomas Terwilliger Lawson T. Winslow Sarah Shriver Footprints for Peace Anne Pace Ean Choo M. Tham Dr. Anne Wolfe Liz and Claire Friedman Candy Pace Mr. and Mrs. Ernest L. Thomas Nancy J. Wolff 2013 ING NYC Marathon Antonina Frolov Alex Parodi James L. Thompson Avon Wonderly Blanca Avery Frontier Communications Joel Paula Sarah Tipple Barbara F. Wood James M. Citrin Fulton Bank of New Jersey Nichole Pellett Mr. and Mrs. Anders Tjernlund Judith Wood Peter Coley Manjit Gardner William Penney

CANCER RESEARCH INSTITUTE 2014 ANNUAL REPORT 41 Helen Coley Nauts Society Etta Baum Rodney Cobb Bernard W. Forrest Ottis C. Harris Mary T. Kraus Raleigh L. Martin The Helen Coley Nauts Society Evelyn Beekman William H. Coffee Carole D. Franklin Helaine T. Harrison Naomi P. Kruse Blanca Mattalia-Wyrzykowski recognizes donors who have included Frank L. Bell Bernice Cohn Clay Frazier Yetta Hatch Murray Kupferman Mildred G. Matz the Cancer Research Institute in their Germaine Benesch Gwendolyn Colburn Lucille O. French Anne M. Hauser Hiroko Kyuba Margaret Mazzey estate plans. Through deferred gifts, William A. Berkey Mr. and Mrs. Raymond Cole Alice M. Fried James Leon Hawkins Rose Lachow Michael I. McBride bequests, trusts, and other planned Stuart Bernard Edythe E. Coleman Anne Fruhner Margaret Hayman Sidney G. LaDue Helen McCann giving instruments, these thoughtful Lucille Bernot Bradley L. Coley Jr. Lena Silverstein Fuhrman Clarence E. Hedberg Anna Lagstein Cecil McClernon individuals safeguard the Institute’s Herta J. Bernstein Louis Comedy Gay H. Gahagan Donald P. Heim C. Linda Lambert Annette McDonald financial future. The Society is named Vincent L. Bessey Phyllis L. Conley Zoltan Galdi Virginia Hemme Jewell Marie Lampkin J. Donald McKinney Jr. in honor of Helen Coley Nauts, CRI’s Grace M. Bishop Vivian E. Conner and Ross I. Conner Eugene G. Gallant Robert J. Hendry Marguerite Landis Norma J. McPherson founder, whose passionate belief John Bittel Lottie M. and Charles H. Cook Peter Gallant Fredrick Charles Henne Louise G. Lane Jan Mears that the immune system could one Guy Bjorkman Salvatore Corsaro Mollie E. Gang Senora Henry Caryl Lou Langford Grace Muriel Mecchi day be harnessed to control cancer Leslie J. Blain Audrey Cowan Sophie Garafola Marion Hewett Elizabeth S. Larkin Nancy Jeanne Merkel has helped make this powerful Anna H. Blankstein Eleanor H. Cromley Salvador Garcia Kay Hilton AnneMarie LaValle Sidney Meskin vision a reality today. To learn more Paula J. Blatter Elmira Crosby Carole Gardner Margot Hoffmann Florence and Edgar Leslie Ethel L. Meyer about making a planned gift to CRI, Ruth Evelyn Bodbyl Julia B. and John R. Curtis B.I. Garlinghouse Nurine Hoke Polly Annenberg Levee Ezilda Michel please contact Emily Livingstone at Eleanor Bodnar Vincent D’Amico E. Yvonne and William O. Geisert Diane and Don Holmes James F. Levens Helen T. Middleton [email protected], or Ronald J. Bogus Annabelle L. Danzig Stella Gentile Eva M. Holmes Frances Leventritt Dorothy Mae Miller call us at (212) 688-7515. Nancy E. and Lawrence H. Bonander Carleen Davis Mildred Gentry Nellie Huff Betty Lou Levin William D. Miller Mary Borbeck Alice Dawes Penelope M. Georgiadis Grace M. Humphrey Esther Levine Maxine and Charles Mindling Anonymous (5) Rita Borenstein Aileen Adele De Long Mercedes C. Gerhard Mary L. Hutchins Beatrice Levy Alex Mitchell Estelle Abas Robina C. Bouchard Eustis Dearborn Patricia J. Getsfried Idell E. and Fred W. Iltner Simon Lifshatz Mr. and Mrs. Charles G. Moore Peter Adams Anna Isabel Boyd Emma Deters Janet M. Gifford Madeline Inguagiato Francis R. Linden Janet P. Morgan Abigail Alderman Hugh R. Boyd Betty Disbrow Regina Gilmour Ruby R. Jankiewicz Harvey A. Linden Maza D. Morris Olga Aleskas Barbara Brown Boyer Adelaide J. Dodge Steven Ginsberg Lynn and Eldon Jasper Patricia A. Lindner Louise and Peter Moseychuk Mildred E. Alexander Frederick Brand Sandford Dody Edna E. Glaessel Warren R. Jecklin George H. Lindskog Bryant A. Muenzen Frederick E. Allard Joy B. Breidling Mary Ann Draus Eleanor Goldberg Doreen and Basil Joffe Roseline Lissak Alexander Munchweiler Edith M. Amateau Lucille Brents Blanche Elizabeth Eckerts Philip Goldblatt Ruth Harvey Johnson Johanna Loeb Irene R. and Martin F. Murphy Peggy Anderson A. Arthur Bressman Rita Eggert Raymond J. Gordinier Doris Kabat Ruby Q. Lokensgard Judith K. Murphy Frances Antopol Brian M. Brewer Dorothy M. Eiser Doris Gordon Rosemary Kaplan Peter J. Lommen Kathryn T. Murphy Freda S. Armstrong Victor E. Broll Earl R. Elliott Jean R. and John G. Gosnell Sally J. Kaplan Bonnie Long Thomas P. Murray Grace Arnold Albert N. Brooks Pauline E. Elliott Norman Gottlieb Sara Katz Albie A. Adams Loving Naomi Myers Geneva A. Arthur Minnie E. Brown Ruth Engelberg Dorothy M. Graham Bertha E. Kaufman Madeline Lukowitz Mayumi Nakagawa and John K. Lai Ruth Ascher Virginia Bruner Valera L. Ennis E. Ruth Grant Samuel Kay Mr. and Mrs. William H. Lyford Rita Nasser Virginia and Rex Ashdown Alfred R. Brunner Helen Epstein Annette and Owen Gray Blanche C. Kelly Gertrude A. Lynch Alice A. Nauts Lee Asher Estate of Anne Luise Buerger Nathan Epstein Bernice E. Grilleaux Jean Kemp Hjordes Diane Lyttle Patricia Navarro Belle Asherman Lucille A. Buland Max G. Eriksen Floyd Dale Grisham Hugh W. Kennedy Eleanor D. MacCracken Paula M. Neal Alice Auerbach Mary C. Bundy Helen B. Esokait Zoe S. Grove Mercedes E. Kent Emilie Machalinski Barbara Lynne Nelson Norman W. Austin Arthur Burkhardt Florence L. and Ned A. Etkin Ronald J. Guglielmino Elsie E. Kiel Catriona Macleod Rose E. Nelson Jeanne Avegno Lois M. Burns and Robert W. Burns Juanita M. Evans Marianne C. Hafner Corinne Kiell William S. Maddenborough Jean Marie Newcomer Else Baier Dale T. Butterwick Mary S. Fadeley Jeanine Hair Theresa A. Kiely David Madsen Freda E. Newton and Olga Baker Joy Biggs Buttle Helen Jean Falk Nelle B. Haire Mary B. Kilroe and Edward L. Kilroe Ferne Magialardo William E. Newton Marion Balen Tracy Campbell Herbert Lynn Fann Adrian Leroy Hall Barbara Kincaide Henrietta Malbin Herb H. Nichols Ella R. Banks Angelina Carbone Barbara Feldman Diane Ham Hilda Kirson Herbert J. Maletz Bernard R. Niewoehner Mary R. Baque Alfred Carlucci Robert I. Fendrich Mr. and Mrs. Virgil Hamby Shirlene Kisak Isabelle C. Malone Geneva W. Nolen Dorothy Barbeau Julia Carlucci Carlos A. Ferrer Frances E. Hanneman Marilyn and Robert Klett Anna Malowany Jacques C. Nordeman Jeanne E. and Jacob A. Barkey Pandora Rudland Carroll Adelaide E. Ferris The Hansen Trust Ruth and Hugo Klotz John Malowany Trust Mary M. Nowak Mr. and Mrs. Kenneth Barmore Donald O. Carswell Louise Egdorf Fescine Lydia C. Hanson Anne Koch Meyer Marcus Mary Nunez William Barr Melba Case Elsie K. Filonchik Loretta D. Hardy Truby Joy Kohl B.M. Marinko Dorothy B. Nurick Florence and Ben Barrack Mary Elizabeth Catto Mary H. and Frances E. Flood Mark L. Hariton Mr. and Mrs. Harry Kompanek Genevieve Martin Margaret M. and Harry A. Oak Rose Barrow Doris M. Clanin Josephine Fonti Evelyn H. Harris Juanita and Fred Koors Louemma Martin Nora Odets Isabella Williams Bartholow and William James Clapp Florence A. Forni Lori Harris Harry A. Kraus Lowell A. Martin Arvilla Ogden Bruce Burdette Bartholow

Helen Coley Nauts, D.Sc. (Hon.), Founder, Cancer Research Institute CANCER RESEARCH INSTITUTE 2014 ANNUAL REPORT 43 Michele A. Ognibene Dorothy and Ernest Rueppel Mary Carol Talerico Centennial Circle Roselyn R. Olken Gloria Ruminsky Maureen Tannehill The Centennial Circle celebrates 2014 Alice Orlich Hedwig Salzer Carl E. Thomas donors who have made a lifelong Mary O’Rourke Lydia B. Scannell George C. Thomas Jr. commitment to supporting the Cancer Anna and Paul Oschwald Martha Schneller Geraldine E. Thomas Research Institute. Members of this Albert Ottinger Virginia Schuettpelz Overton Arnold Thompson loyal group have made 75 or more Lilly E. Pace Helen R. Schutt Viola Mae Thompson gifts to CRI during their lifetime. FINANCIAL HIGHLIGHTS Lily Pace and Floyd Pace Ruth Schwartzman Anita and John R. Timmel Marjorie W. Packwood Rev. Harold Bend Sedgwick Carola S. Trier Ellen Beloff Erma N. Panfilio Dorothy K. Sefcovic Jessie C. Tripp Mr. and Mrs. Ira M. Boskey Andrew Reid Paton Clara Senk John D. Turkel Lauren B. Burns PUBLIC SUPPORT & REVENUE OPERATING EXPENSES Eleanor T. Patterson Natalie Shebs Zelda M. Uthe Harriet E. Charles Carmen F. Patti Dorothy M. Sheese Paul E. Van Cleve Mr. and Mrs. Irving Cohen $27.5MM $25.0MM Foster Clae Patton Margaret Sheets William R. Vass Selma Davidson Frederick V. Payne Donald Sherwood Josephine S. Villeman Mr. and Mrs. Stephen C. Elkin Nancy Elizabeth Pease Renee and Irwin Shishko Myrtle H. and Antone L. Vinelli Rhoda Fischman April Peck Laura M. Sidener Anne D. Vinton Anne E. Gentile Research Donald H. Peper Lottie Siegel Linda Vono Mr. and Mrs. Gary R. Ginsberg Contributions $18.0MM*, 72% Agnes Phelps Katherine U. Silva Esther and Stanley Wade Mr. and Mrs. Leonard Gold $19.1MM, 70% *$19.2MM awarded minus Elizabeth F. Phillips Belle V. Silverstein Ethel Wagner Helen A. Green $1.2MM in early terminations John Piercy Augusta Simon David Walker Renee A. Harris from grants made in prior years Harriet-Anne Pierson Roma Sinclair Robert B. Walker Harvey A. Herbert Investments & Other Rochelle Pinz Estelle Singer Thomas Walsh Mrs. Stephen M. Kellen $3.2MM, 12% Cynthia Joy Platt Jean V. Sirles Julia Walz Mr. and Mrs. Elliot Leitner Education Dorothy Plumb Alice Jean Smith Lea Ward Mr. and Mrs. Michael Levy $4.0MM, 16% Mabel Plunkett Catherine M. Smith Irene M. Watkins Charles J. Lurie Special Events Nick J. Pokea Clarence Smith Dorothy Waugh Mr. and Mrs. Charles Lyttle II $3.0MM, 10% Marketing & Fundraising David M. Polen Mr. and Mrs. Ernest B. Smith Ione A. and Albert L. Weickert Mr. and Mrs. Arthur Nasso $2.0MM, 8% Esther Posin Howard G. Smith Rose C. Weisel Jacques C. Nordeman Bequests & Memorials Richard Potruch Kevin L. Smith Elizabeth A. Weiser Esther Ravin Administration Despina Poulos Patricia Smith Leonard Weiss Mr. and Mrs. Jonas J. Rieter $2.2MM, 8% Clifford Presky Willie Mae Smith Robert P. West Mr. and Mrs. Milton S. Rubin $1.0MM, 4% Joyce A. Prime Ruth Sneve Anna M. Wheeler Clifford M. Rutter Dorothy S. Pritchard Vera Marie Snider Agnella L. Widmer Mr. and Mrs. Sydney Shuman Aspasia Radoumis Esther and Harold Sohmer Geneva K. Widmer Mr. and Mrs. Marvin Stillman Carol Diane Ranken Fred E. Spencer Margaret Wiegandt William Tracy MESSAGE FROM THE CHIEF FINANCIAL OFFICER James B. Ransohoff Jacqueline Spencer Saul J. Wiener Mr. and Mrs. Everett L. Wessner In the link below, we provide detailed financial statements for the Cancer Esther Reed William Sprenger Loretta M. Wiggins Alan N. White Research Institute (CRI) for fiscal year 2014 (July 1, 2013, to June 30, 2014). Harry Delos Reich Remy R. Sprouse Lorna Katherine Wilkinson Florence Wisler Helen Relkin Brenda M. St. James Harriet B. and Francis I. Wilks The graphics above illustrate a breakdown of revenue and expenses in both Floris J. Renk Gerald J. Steinberg Josephine H. Williams real dollars and percentage for the same period. LaDonna Reynolds Leopold Steindecker Ora Brown Windle We at the Cancer Research Institute hold accountability, transparency, and James F. Rice Anna Stephan Mr. and Mrs. Norman J. Woodhams efficiency as core values in our work. As a result, we devoted more than 88% Florence V. Richardson Robert L. Stevens Frederick W. Woodworth Adam J. Richter Mary Malcolm Stiles John A. Wootton of our operating expenses to programs. In fiscal year 2014, this meant that we Virginia L. Riddle Fay Strout and Laurence Cecil Strout Josephine Wootton invested more than $22 million in research and education programs. The 2014 Robert T. Ridley Frieda Coons Studley Nettie Wright financial highlights are above. Adeline Ringeisen Dorothy H. Sullivan Ethel R. Young Dr. Fred Ringel Myrtle B. Summers Marion E. Youngberg To CRI’s friends and supporters, we thank you for your contribution as Veronica A. Rose Agnes Katscher Sunley Gloria Zaino we work to fund science that will have the most impact in bringing cancer Susan Rosenberg John Supon Marion Zell immunotherapy to more patients. Together, we will conquer cancer. Alfred R. Massidas Moises Rubiano Mary and James Suthard View our audited financial statements at www.bit.ly/CRIfinancials. Chief Financial Officer

CANCER RESEARCH INSTITUTE 2014 ANNUAL REPORT 45 CRI Scientific Advisory Council meeting, early 1970s (from left to right): Lloyd J. Old, M.D., Helen Coley Nauts, Edmund Klein, M.D., Robert A. Good, M.D., Ph.D., and Herbert F. Oettgen, M.D. STEWARDS OF THE ORGANIZATION For more than 60 years, scientific and philanthropic leaders have steered the Cancer Research Institute with their long-term, significant commitments to the Institute. They support CRI and its mission not only through academic and financial support, but also through astute governance and active participation in the organization’s initiatives.

Board of Trustees Secretary Patrick J. Durkin Alexander P. Lynch Managing Director Partner Thomas G. Mendell Barclays Capital White Deer Energy Chairmen T.G. Mendell Corp. New York, NY New York, NY New York, NY John B. Fitzgibbons John E. Eckerson Andrew M. Paul Chairman and CEO Members Founding Partner and Managing General Partner Basin Holdings US LLC Co-Chief Investment Officer Enhanced Equity Funds New York, NY Peter L. Bloom Claren Road Asset Management, LLC New York, NY Advisory Director New York, NY Paul C. Shiverick General Atlantic LLC Brian Riano Partner Greenwich, CT Sean P. Fahey Co-Founder and CEO Seminole Management Company, Inc. Founding Partner and Claren Road Asset Management, LLC New York, NY Jennifer L. Brorsen Co-Chief Investment Officer New York, NY Bronxville, NY Claren Road Asset Management, LLC Vice Chairmen New York, NY Lief D. Rosenblatt James M. Citrin Partner Edgar R. Berner Leader, CEO Practice Carlos A. Ferrer ENE Investco Management Partner Spencer Stuart Founder and Managing Member New York, NY John Lang, Inc. Stamford, CT Ferrer Freeman & Company, LLC New York, NY Greenwich, CT Howard B. Schiller Sandra Coudert Graham Executive Vice President and CFO Donald J. Gogel Oyster Bay, NY Margot E. Freedman Valeant Pharmaceuticals International, Inc. Chairman and CEO Larchmont, NY Bridgewater, NJ Clayton, Dubilier & Rice, LLC Maurice J. Cunniffe New York, NY Chairman and CEO Mitchell H. Gold, M.D. Paul J. Sekhri Vista Capital Corporation Founder and Managing Partner Senior Vice President Jacques C. Nordeman Greenwich, CT Alpine BioVentures Sanofi Chairman Seattle, WA Bridgewater, NJ / Paris, France Nordeman Grimm, Inc. W. Robert Dahl New York, NY Principal Oliver R. Grace Jr. Frank V. Sica WRD Capital President Partner Treasurer Darien, CT Associated Asset Management, Inc. Tailwind Capital Palm Beach, FL New York, NY Geoffrey O. Coley Glenn J. DeSimone International Business Head Greenwich, CT Michael M. Kellen James A. Stern Mitsubishi UFJ Securities (USA), Inc. Co-President Chairman and Founder New York, NY Arnhold and S. Bleichroeder Holdings, Inc. The Cypress Group New York, NY New York, NY

CANCER RESEARCH INSTITUTE 2014 ANNUAL REPORT 47 Michael B. Targoff Bruce D. Dixon Scientific Advisory Council Jonathan S. Cebon, Ph.D., FRACP 4 Patrick Hwu, M.D. 5 Tak W. Mak, Ph.D., D.Sc., F.R.S.C. 2,7 Jeffrey V. Ravetch, M.D., Ph.D. 2 Emil R. Unanue, M.D. 2 Vice Chairman of the Board Retired Partner Austin Health/Ludwig Cancer The University of Texas MD Anderson The Campbell Family Institute for The Rockefeller University, Washington University School of Loral Space & Communications Ernst & Young Director Research, Melbourne, Australia Cancer Center, Houston, TX Breast Cancer Research at Princess New York, NY Medicine, St. Louis, MO New York, NY Greenwich, CT Margaret Hospital, University Health 3,6 4,5,6 6 7 James P. Allison, Ph.D. 2,3,5,6,7 Vincenzo Cerundolo, M.D., Ph.D. Elizabeth M. Jaffee, M.D. Network, University of Toronto, Stanley R. Riddell, M.D. Ulrich H. von Andrian, M.D., Ph.D. Andrew K. Tsai Mrs. Charles G. Gambrell The University of Texas MD Anderson MRC Human Immunology Unit, Johns Hopkins University School Toronto, Canada Fred Hutchinson Cancer Research Harvard Medical School and Boston Managing Principal Charlotte, NC Cancer Center, Houston, TX University of Oxford, Oxford, United of Medicine, The Sidney Kimmel Center, Seattle, WA Children’s Hospital, Boston, MA, and Chalkstream Capital Group, L.P. Kingdom Comprehensive Cancer Center, Philippa C. Marrack, Ph.D. 2 The Ragon Institute of Massachusetts 2,7 New York, NY William O. Grabe Associate Directors Baltimore, MD National Jewish Health and the Alexander Y. Rudensky, Ph.D. General Hospital, MIT, and Harvard Advisory Director Max D. Cooper, M.D. 2 University of Colorado, Denver, Memorial Sloan Kettering Cancer University, Cambridge, MA 4 Diane Tuft General Atlantic LLC Glenn Dranoff, M.D. 3,4,6 Emory University School of Medicine, Carl H. June, M.D. Denver, CO Center, New York, NY New York, NY New York, NY Atlanta, GA Abramson Cancer Center, Perelman Robert H. Vonderheide, M.D., D.Phil. 6 Dana-Farber Cancer Institute, 3,6 Boston, MA School of Medicine at the University Cornelis J.M. Melief, M.D., Ph.D. Bijan Safai, M.D., D.Sc. Abramson Cancer Center, Perelman Heidi Ueberroth Mrs. Oliver R. Grace Lisa M. Coussens, Ph.D. of Pennsylvania, Philadelphia, PA Leiden University Medical Center, New York Medical College, School of Medicine at the University Director New York, NY Carl F. Nathan, M.D. 2,3,7 Oregon Health & Science University, Leiden, The Netherlands Valhalla, NY of Pennsylvania, Philadelphia, PA Pebble Beach Company Portland, OR Michael Kalos, Ph.D. 5 Weill Cornell Medical College, 2,5 2,3 7 New York, NY Joyce Green New York, NY Eli Lilly & Company, New York, NY Ira Mellman, Ph.D. Shimon Sakaguchi, M.D., Ph.D. Hao Wu, Ph.D. Westhampton Beach, NY Peter Cresswell, Ph.D. 2,7 Genentech, South San Francisco, CA Immunology Frontier Research Center, Boston Children’s Hospital and 2 Lauren S. Veronis Ellen Puré, Ph.D. 7 Yale University School of Medicine, Michael Karin, Ph.D. Osaka University, Osaka, Japan Harvard Medical School, Boston, MA New York, NY Ann W. Jackson New Haven, CT University of California, San Diego, Malcolm A.S. Moore, D.Phil. University of Pennsylvania School of 7 7 New York, NY Veterinary Medicine, Philadelphia, PA La Jolla, CA Memorial Sloan Kettering Cancer Lawrence E. Samelson, M.D. Cassian Yee, M.D. Ronald G. Weiner Charles G. Drake, M.D., Ph.D. 5,6 Center, New York, NY National Cancer Institute, NIH, The University of Texas MD Anderson 6 President Arthur L. Jacobson Robert D. Schreiber, Ph.D. 2,3,6,7 Johns Hopkins University School John M. Kirkwood, M.D. Bethesda, MD Cancer Center, Houston, TX Perelson Weiner LLP Indian Wells, CA of Medicine, The Sidney Kimmel University of Pittsburgh Cancer Lee Nadler, M.D. Washington University School of 3,7 1,2,3 New York, NY Medicine, St. Louis, MO Comprehensive Cancer Center, Institute, Pittsburgh, PA Dana-Farber Cancer Institute, Hans Schreiber, M.D., D.MSc., Ph.D. Rolf M. Zinkernagel, M.D., Ph.D. Robert A. Posner Baltimore, MD Boston, MA University of Chicago, Chicago, IL University of Zürich, Zürich, 2,3 James A. Wiatt Managing Director 4,5,6 George Klein, M.D., D.Sc. Switzerland Jedd D. Wolchok, M.D., Ph.D. 7 4,5,6 CEO Commonwealth Holding, LP Memorial Sloan Kettering Cancer Michael L. Dustin, Ph.D. Karolinska Institute, Stockholm, Kunle Odunsi, M.D., Ph.D. Ton N. Schumacher, Ph.D. CIW Consulting Brookline, MA Center and Ludwig Cancer Research, NYU Langone Medical Center, Sweden Roswell Park Cancer Institute, The Netherlands Cancer Institute, 1 Nobel Laureate Los Angeles, CA New York, NY New York, NY Buffalo, NY Amsterdam, and Leiden University, Julian Robertson Alexander Knuth, M.D. 3,4,6 Leiden, The Netherlands 2 Member, National Academy 2 3,7 of Sciences Trustees Emeriti Chairman Richard A. Flavell, Ph.D., FRS National Center for Cancer Care Drew M. Pardoll, M.D., Ph.D. 3 Members 4 Member, Academy of Tiger Management LLC Yale University School of Medicine, and Research, Hamad Medical Johns Hopkins University School Craig L. Slingluff Jr., M.D. Cancer Immunology Carter F. Bales New York, NY Frederick W. Alt, Ph.D. 2,7 New Haven, CT Corporation, Doha, Qatar of Medicine, The Sidney Kimmel University of Virginia School of 4 Clinical Accelerator Scientific Chairman and Managing Director Howard Hughes Medical Institute, Comprehensive Cancer Center, Medicine, Charlottesville, VA Advisory Committee 6 2,7 5 NewWorld Capital Group, LLC Winthrop H. Smith Jr. Boston Children’s Hospital, and Thomas F. Gajewski, M.D., Ph.D. Lewis L. Lanier, Ph.D. Baltimore, MD Cancer Immunotherapy Consortium Leadership Committee New York, NY Chairman Harvard Medical School, Boston, MA University of Chicago, University of California, San Francisco, Mark J. Smyth, Ph.D. Summit Ventures NE, LLC Chicago, IL San Francisco, CA William E. Paul, M.D. 2 QIMR Berghofer Medical Research 6 CLIP Review Committee 7 Howard P. Berkowitz Warren, VT National Institute of Allergy and Institute, Queensland, Australia Postdoctoral Fellowship Richard Axel, M.D. 1,2 Review Committee New York, NY Laurie H. Glimcher, M.D. 2 Hyam I. Levitsky, M.D. 5 Infectious Diseases, NIH, Columbia University Medical Center, 3,5,6 New York, NY Weill Cornell Medical College, Roche Glycart AG, Schlieren, Bethesda, MD Pramod K. Srivastava, M.D., Ph.D. Donald G. Calder New York, NY Switzerland, and Johns Hopkins University of Connecticut Health 2,3 Chairman 6,7 University School of Medicine, Klaus Rajewsky, M.D. Center, Farmington, CT Nina Bhardwaj, M.D., Ph.D. 3,7 Clear Harbor Asset Management Tisch Cancer Institute, Icahn School of Philip D. Greenberg, M.D. Baltimore, MD Max-Delbrück Center for Molecular New York, NY University of Washington School of Medicine, Berlin, Germany Susumu Tonegawa, Ph.D. 1,2 Medicine at Mount Sinai, 2,7 New York, NY Medicine and Fred Hutchinson Cancer Dan R. Littman, M.D., Ph.D. Massachusetts Institute of Technology, Stuart P. Davidson Research Center, Seattle, WA NYU Langone Medical Center, Anjana Rao, Ph.D. 2,7 Cambridge, MA Managing Director Harvey Cantor, M.D. 2 New York, NY La Jolla Institute for Allergy and Labrador Ventures Axel Hoos, M.D., Ph.D. 5 Immunology, Sanford Consortium for Giorgio Trinchieri, M.D. 3,6,7 Dana-Farber Cancer Institute, 5 Menlo Park, CA Boston, MA GlaxoSmithKline, Collegeville, PA Nils Lonberg, Ph.D. Regenerative Medicine, La Jolla, CA National Cancer Institute, NIH, Bristol-Myers Squibb, Milpitas, CA Frederick, MD

CANCER RESEARCH INSTITUTE 2014 ANNUAL REPORT 49 CVC Trials Network Michel Sadelain, M.D., Ph.D. • Lawrence Fong, M.D., University of • Andrew G. Sikora, M.D., Ph.D., • Nicolas Van Baren, M.D., Ph.D., Cancer Immunotherapy Memorial Sloan Kettering Cancer California, San Francisco Baylor College of Medicine Ludwig Cancer Research, Belgium Consortium Director and Scientific Advisory Center, New York, NY • Leena Gandhi, M.D., Ph.D., Dana- • Craig L. Slingluff Jr., M.D., • Maries van den Broek, Ph.D., Committee Chair Farber Cancer Institute University of Virginia Cancer Center University of Zürich, Switzerland Co-Directors Neil H. Segal, M.D., Ph.D. • Sacha Gnjatic, Ph.D., Icahn School • Mario Sznol, M.D., Yale Cancer • Benoît J. Van den Eynde, M.D., Jedd D. Wolchok, M.D., Ph.D. Memorial Sloan Kettering Cancer of Medicine at Mount Sinai Center Ph.D., Ludwig Cancer Research, James P. Allison, Ph.D. Memorial Sloan Kettering Cancer Center, New York, NY • Philip D. Greenberg, M.D., • Suzanne L. Topalian, M.D., Johns Belgium The University of Texas MD Anderson Center and Ludwig Cancer Research, University of Washington, Fred Hopkins University School of • Pierre van der Bruggen, Ph.D., Cancer Center, Houston, TX New York, NY Andrew G. Sikora, M.D., Ph.D. Hutchinson Cancer Research Center Medicine Ludwig Cancer Research, Belgium Baylor College of Medicine, • F. Stephen Hodi Jr., M.D., Dana- • Ralph R. Weichselbaum, M.D., • Sjoerd Henricus van der Burg, Axel Hoos, M.D., Ph.D. Scientific Advisory Committee Houston, TX Farber Cancer Institute, Harvard University of Chicago Ph.D., Leiden University Medical GlaxoSmithKline, Collegeville, PA Medical School • Jedd D. Wolchok, M.D., Ph.D., Center, The Netherlands Timothy A. Chan, M.D., Ph.D. Craig L. Slingluff Jr., M.D. • Elizabeth M. Jaffee, M.D., Johns Memorial Sloan Kettering Cancer • Alfred Zippelius, M.D., University of Leadership Committee Members Memorial Sloan Kettering Cancer University of Virginia Cancer Center, Hopkins University School of Center, Ludwig Cancer Research Basel, Switzerland Center, New York, NY Charlottesville, VA Medicine • Cassian Yee, M.D., The University Charles G. Drake, M.D., Ph.D. • Carl H. June, M.D., Perelman of Texas MD Anderson Cancer Asia Johns Hopkins University School of Jonathan S. Cebon, Ph.D., FRACP Finance, Intellectual Property, School of Medicine, University of Center • Shinichi Kageyama, M.D., Mie Medicine, Baltimore, MD Austin Health/Ludwig Cancer Clinical Trials Management, and Pennsylvania • Hassane M. Zarour, M.D., University School of Medicine, Research, Melbourne, Australia Administration • Achim Jungbluth, M.D., Memorial University of Pittsburgh Cancer Japan Patrick Hwu, M.D. Sloan Kettering Cancer Center Institute • Alexander Knuth, M.D., National The University of Texas MD Anderson George Coukos, M.D., Ph.D. Cancer Research Institute • Thomas J. Kaley, M.D., Memorial Center for Cancer Care and Cancer Center, Houston, TX University Hospital of Lausanne, Lynne A. Harmer Sloan Kettering Cancer Center Europe Research, Qatar Lausanne, Switzerland Adam Kolom • John M. Kirkwood, M.D., University • Maha Ayyoub, Ph.D., Centre de • Eiichi Nakayama, M.D., Ph.D., Elizabeth M. Jaffee, M.D. Vanessa Lucey, Ph.D., MBA of Pittsburgh Cancer Institute Lutte Contre Le Cancer Nantes- Kawasaki University of Medical Johns Hopkins University School of Glenn Dranoff, M.D. Jill O’Donnell-Tormey, Ph.D. • Alexander M. Lesokhin, M.D., Atlantique, France Welfare, Japan Medicine, Baltimore, MD Dana-Farber Cancer Institute, Memorial Sloan Kettering Cancer • Luigi Buonaguro, M.D., National • Hiroyoshi Nishikawa, M.D., Ph.D., Boston, MA Ludwig Cancer Research Center Cancer Institute Pascale, Italy Osaka University, Japan Michael Kalos, Ph.D. Pär Olsson, Ph.D. • Kunle Odunsi, M.D., Ph.D., Roswell • Vincenzo Cerundolo, M.D., Ph.D., • Hiroshi Shiku, M.D., Mie University Eli Lilly & Company, New York, NY Lawrence Fong, M.D. Linda Pan, Pharm.D. Park Cancer Institute University of Oxford, United School of Medicine, Japan University of California, San Francisco, Aileen Ryan • Hideho Okada, M.D., Ph.D., Kingdom • Hisashi Wada, M.D., Ph.D., Osaka Hyam I. Levitsky, M.D. San Francisco, CA Jonathan Skipper, Ph.D. University of California, San • George Coukos, M.D., Ph.D., University, Japan Roche Glycart AG, Schlieren, Ralph Venhaus, M.D. Francisco University Hospital of Lausanne, Switzerland, and Johns Hopkins Elizabeth M. Jaffee, M.D. • Drew M. Pardoll, M.D., Ph.D., Switzerland Australia University School of Medicine, Johns Hopkins University School of Global Clinician and Scientist Johns Hopkins University School of • Dirk Jäger, M.D., National Center • Jonathan S. Cebon, Ph.D., FRACP, Baltimore, MD Medicine, Baltimore, MD Membership Medicine for Tumor Diseases, University Austin Health/Ludwig Cancer • Marshall R. Posner, M.D., Icahn Clinic of Heidelberg, Germany Research Nils Lonberg, Ph.D. Carl H. June, M.D. United States School of Medicine at Mount Sinai • Elke Jäger, M.D., Krankenhaus • Mark J. Smyth, Ph.D., QIMR Bristol-Myers Squibb, Milpitas, CA Abramson Cancer Center, Perelman • James P. Allison, Ph.D., The • David Reardon, M.D., Dana-Farber Nordwest, Germany Berghofer Medical Research School of Medicine at the University University of Texas MD Anderson Cancer Institute • Judith Kroep, M.D., Ph.D., Leiden Institute Ira Mellman, Ph.D. of Pennsylvania, Philadelphia, PA Cancer Center • Antoni Ribas, M.D., Ph.D., UCLA University Medical Center, The Genentech, South San Francisco, CA • Nina Bhardwaj, M.D., Ph.D., Icahn Medical Center Netherlands Alexander Knuth, M.D. School of Medicine at Mount Sinai • Michel Sadelain, M.D., Ph.D., • Simon A. Laban, M.D., University of Kunle Odunsi, M.D., Ph.D. National Center for Cancer Care • Timothy A. Chan, M.D., Ph.D., Memorial Sloan Kettering Cancer Ulm, Germany Roswell Park Cancer Institute, and Research, Hamad Medical Memorial Sloan Kettering Cancer Center • Cornelis J.M. Melief, M.D., Ph.D., Buffalo, NY Corporation, Doha, Qatar Center • Yvonne Saenger, M.D., Icahn Leiden University Medical Center, • Hearn Jay Cho, M.D., Ph.D., Icahn School of Medicine at Mount Sinai The Netherlands Pramod K. Srivastava, M.D., Ph.D. Kunle Odunsi, M.D., Ph.D. School of Medicine at Mount Sinai • Neil H. Segal, M.D., Ph.D., • Pedro J. Romero, M.D., University University of Connecticut School of Roswell Park Cancer Institute, • Glenn Dranoff, M.D., Dana-Farber Memorial Sloan Kettering Cancer Hospital of Lausanne, Switzerland Medicine, Farmington, CT Buffalo, NY Cancer Institute Center • Daniel E. Speiser, M.D., University • Gavin P. Dunn, M.D., Ph.D., • Padmanee Sharma, M.D., Ph.D., Hospital of Lausanne, Switzerland Jedd D. Wolchok, M.D., Ph.D. Antoni Ribas, M.D., Ph.D. Washington University The University of Texas MD • Danila Valmori, Ph.D., Centre de Memorial Sloan Kettering Cancer UCLA Medical Center, Los Angeles, CA Anderson Cancer Center Lutte Contre Le Cancer Nantes- Center and Ludwig Cancer Research, Atlantique, France New York, NY

Cancer Immunotherapy Consortium Co-Director Axel Hoos, M.D., Ph.D., of GlaxoSmithKline CRI Staff Emily Livingstone Development Associate Senior Staff Vanessa Lucey, Ph.D., MBA Jill O’Donnell-Tormey, Ph.D. Senior Research Analyst CEO and Director of Scientific Affairs Alexandra Mulvey Brian M. Brewer Associate Director of Communications Director of Marketing and Communications Shasell Negron Office Manager / Workplace Giving Lynne A. Harmer Campaign Manager Director of Grants Administration and Special Events Kasturi “Devi” Sharma Donations Processing Manager Alfred R. Massidas CFO and Director of Human Resources Marla Sincavage Manager, Corporate and Foundation Sharon Slade Giving Director of Strategic Initiatives Matthew Tontonoz Staff Science Writer Young Philanthropists Council members Alexis Feldman, Emily Slater, Samantha Knapik, Kate Cucco, and Sean Kiely Hannah Belisle Denise Upton Development Associate Grants Administrator

Young Philanthropists Members Kate Cucco Nicole Negrin Emily Helck Jasmine Wright Council New York State Assembly Ralph Lauren Corporation Online Community Manager Assistant to the CEO Megan Bannigan New York, NY New York, NY Qing Hua Zhang Chair Debevoise & Plimpton Rupinder Kaur New York, NY Alexis Hovey Kristen Rathfelder Database Administrator Assistant Controller Samantha Knapik Ralph Lauren Och Ziff Capital Management Consultant On Deck Capital Robin Beltrani New York, NY New York, NY Erin Kim New York, NY GlobeTax Services, Inc. Events Coordinator New York, NY Marissa Kaplan Josephine Vella Adam Kolom Coley to Cure Managing Director, Read more about CRI’s pioneering role in developing Vice Chair ConMed Corporation United States Attorney’s Office, EDNY Michelle Liew George Bergamo New York, NY Brooklyn, NY Digital Media Manager Clinical Accelerator cancer immunotherapy over the past six decades at www.bit.ly/CRIretrospective. Emily Slater Centauri Investment Management Cantor Fitzgerald/BGC Partners New York, NY Sean Kiely Kendall Wrigley New York, NY The New York Retail Report Vitech Systems Group Anne Bracegirdle New York, NY New York, NY Secretary Christie’s New York, NY Mark Koch Priyanka Sewhani AT&T JP Morgan Christina Brown Global Broadcast Services New York, NY HealthFirst New York, NY New York, NY Treasurer Sharon Minick Emily Craft SiriusXM Radio Eric Adams The Peter and Carmen Lucia Buck Hoboken, NJ JP Morgan Foundation, Inc. New York, NY New York, NY

CANCER RESEARCH INSTITUTE 2014 ANNUAL REPORT 53 GIVING TO THE CANCER RESEARCH INSTITUTE The Cancer Research Institute (CRI) has a long tradition of responsible stewardship of donor funds. We receive the highest marks from charity watchdog groups, including an “A” grade from the American Institute of Philanthropy and a four-star rating from Charity Navigator. CRI also meets all 20 standards of the Better Business Bureau Wise Giving Alliance. Donors to CRI can be confident that their donation, in any amount, will do the most good possible. To help you make the most fitting and fulfilling contribution to CRI, please contact our Development Office at (212) 688-7515 or send an email to [email protected].

OUTRIGHT GIFTS PLANNED GIFTS COMMUNITY FUNDRAISING

Cash Donations by check or credit Planned gifts include bequests Want to hold a bake sale to raise card may be sent directly to CRI made through a living trust or money for cancer research? How or processed through our secure inclusion of the Cancer Research about a fashion show, dinner, or a website at www.bit.ly/CRIdonate. Institute in your will as a beneficiary music concert? Maybe you’re getting of cash, securities, or personal married and would prefer guests give Property other than cash Donating property. Your bequest should include to charity. We offer support for these securities, automobiles, and similar the Institute’s federal tax ID number and other fundraising ideas. Visit our properties can often be a tax-efficient (13-1837442) and a statement such website at www.bit.ly/CRIfundraise method for making a meaningful gift as the following: to learn more about how you can to CRI. organize your own special event. “I bequeath to the Cancer Research Ask Workplace giving programs Institute, a not-for-profit corporation FOR CORPORATE FRIENDS your human resources department of the State of New York, having its if your company has a plan through principal office at One Exchange No one organization, company, which you can contribute to CRI. Plaza, 55 Broadway, Suite 1802, or group can solve the cancer New York, New York 10006, the sum problem alone. It takes collaboration Matching gifts Contact your human of $_____ for its general operating to change the course of cancer. resources department to inquire if purposes.” CRI welcomes opportunities your employer matches contributions to work together with others to or browse our online matching gift You should, of course, always develop research, educational, database to see if your company is Since 1953, the Cancer Research consult your attorney and tax advisor and awareness-building programs listed at www.bit.ly/CRImatch. Institute has invested $282 million for the formal writing of your will and designed to advance cancer to discuss the tax implications of any immunotherapy. Contact Sharon to fund nearly 3,000 scientists all form of planned giving. Slade at [email protected] or (212) 688-7515 x230 to learn more. over the world.

Sarah Trifari, Ph.D., CRI postdoctoral fellow at La Jolla Institute for Allergy and Immunology CANCER RESEARCH INSTITUTE 2014 ANNUAL REPORT 55 NATIONAL HEADQUARTERS

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