medRxiv preprint doi: https://doi.org/10.1101/2020.12.06.20244814; this version posted December 8, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . Epigenetic Signatures of Human Myocardium and Brown Adipose Tissue Revealed with Simultaneous Positron Emission Tomography and Magnetic Resonance of Class I Histone Deacetylases. 1David Izquierdo-Garcia, 1Jacob M. Hooker, 1Frederick A. Schroeder, 1Choukri Mekkaoui, 1Tonya M. Gilbert, 1Marcello Panagia, 2Cheryl Cero, 1Lindsey Rogers, 1Anisha Bhanot, 1Changning Wang, 2Aaron M. Cypess, 1,*Ciprian Catana, 1,3,*David E. Sosnovik. 1Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston MA 2Translational Physiology Section, Diabetes, Endocrinology, and Obesity Branch, NIDDK, National Institutes of Health, Bethesda MD 3Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston MA * Contributed Equally Correspondence: David E. Sosnovik, MD FACC Cardiovascular Research Center Massachusetts General Hospital and Harvard Medical School 149 13th St, Charlestown, MA 02129 Tel: (617) 724-1679 Email:
[email protected] Word count: 6025 NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice. medRxiv preprint doi: https://doi.org/10.1101/2020.12.06.20244814; this version posted December 8, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.