University of South Florida Scholar Commons Graduate Theses and Dissertations Graduate School April 2019 Enhancing Immunotherapeutic Interventions for Treatment of Chronic Lymphocytic Leukemia Kamira K. Maharaj University of South Florida,
[email protected] Follow this and additional works at: https://scholarcommons.usf.edu/etd Part of the Biology Commons, Cell Biology Commons, and the Immunology and Infectious Disease Commons Scholar Commons Citation Maharaj, Kamira K., "Enhancing Immunotherapeutic Interventions for Treatment of Chronic Lymphocytic Leukemia" (2019). Graduate Theses and Dissertations. https://scholarcommons.usf.edu/etd/8385 This Dissertation is brought to you for free and open access by the Graduate School at Scholar Commons. It has been accepted for inclusion in Graduate Theses and Dissertations by an authorized administrator of Scholar Commons. For more information, please contact
[email protected]. Enhancing Immunomodulatory Therapeutic Interventions for Chronic Lymphocytic Leukemia by Kamira K. Maharaj A dissertation submitted in partial fulfillment Of the requirements for the degree of Doctor of Philosophy Department of Cancer Biology College of Arts and Sciences University of South Florida Major Professor: Javier Pinilla-Ibarz, M.D., Ph.D. Jose Conejo-Garcia, M.D., Ph.D. Sheng Wei, M.D. P.K. Epling-Burnette, Ph.D., Pharm.D. Shari Pilon-Thomas, Ph.D. John Pagel, M.D. Date of Approval: February 6, 2019 Keywords: HDAC, CLL, T cell, B cell, immune, ibrutinib Copyright © 2019, Kamira K. Maharaj DEDICATION I would like to dedicate this dissertation first and foremost to my family, who have tirelessly supported me in the pursuit of education. To both of my grandmothers, who believed in the power of education for their daughters and granddaughters.