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Bluetongue Virus Replication, Molecular and Structural Biology
Bluetongue virus and disease Vet. Ital., 40 (4), 426-437 Bluetongue virus replication, molecular and structural biology P.P.C. Mertens(1), J. Diprose(2), S. Maan(1), K.P. Singh(1), H. Attoui(3) & A.R. Samuel(1) (1) Orbivirus Group, Institute for Animal Health, Pirbright Laboratory, Pirbright, Woking, Surrey GU24 0NF, United Kingdom (2) Division of Structural Biology, The Henry Wellcome Building, Oxford University, Roosevelt Drive, Oxford OX3 7BN, United Kingdom (3) Unité des Virus Emergents EA3292, Université de la Méditerranée et EFS Alpes-Méditerranée, Fa27 boulevard Jean Moulin, Faculté de Médecine de Marseille, 13005 Marseilles, France Summary The icosahedral bluetongue virus (BTV) particle (~80 nm diameter) is composed of three distinct protein layers. These include the subcore shell (VP3), core-surface layer (VP7) and outer capsid layer (VP2 and VP5). The core also contains ten dsRNA genome segments and three minor proteins (VP1[Pol], VP4[CaP]and VP6[Hel]), which form transcriptase complexes. The atomic structure of the BTV core has been determined by X-ray crystallography, demonstrating how the major core proteins are assembled and interact. The VP3 subcore shell assembles at an early stage of virus morphogenesis and not only determines the internal organisation of the genome and transcriptase complexes, but also forms a scaffold for assembly of the outer protein layers. The BTV polymerase (VP1) and VP3 have many functional constraints and equivalent proteins have been identified throughout the Reoviridae, and even in some other families of dsRNA viruses. Variations in these highly conserved proteins can be used to identify members of different genera (e.g. -
Identificación De Culicoides Spp. Como Vectores Del Virus Lengua Azul En Áreas De Ovinos Seropositivos De Pucallpa, Ucayali
UNIVERSIDAD NACIONAL MAYOR DE SAN MARCOS FACULTAD DE MEDICINA VETERINARIA UNIDAD DE POSGRADO Identificación de Culicoides spp. como vectores del virus Lengua Azul en áreas de ovinos seropositivos de Pucallpa, Ucayali TESIS Para optar el Grado Académico de Magíster en Ciencias Veterinarias con mención en Salud Animal AUTOR Dennis Alexander NAVARRO MAMANI ASESOR Hermelinda RIVERA GERÓNIMO Lima – Perú 2017 DEDICATORIA Dedicó este trabajo a mi madre, Maria, que con su demostración de una madre ejemplar me ha enseñado a no desfallecer ni rendirme ante nada y siempre perseverar. A mi asesora la Dra. Hermelinda Rivera por su valiosa guía y asesoramiento, quien con su ejemplo me ha mostrado la dedicación y pasión por el trabajo que uno realiza AGRADECIMIENTOS En primer lugar, al Laboratorio de Microbiología y Parasitología, Sección Virología de la Facultad de Medicina Veterinaria de la Universidad Nacional Mayor de San Marcos, lugar donde se ejecutó y planificó el presente trabajo. En sentido especial, a la Mg. MV. Hermelinda Rivera Gerónimo, quien me asesoró en la ejecución de este trabajo de investigación. Al Instituto Veterinario de Investigaciones tropicales y de Altura Pucallpa (IVITA- PUCALLPA), donde se realizó la colecta de los insectos capturados. En sentido especial, al Mg. MV. Juan Alexander Rondon Espinoza, quien me contacto con las granjas y coordinó los muestreos. Al Mg. Blgo. Abraham Germán Cáceres Lázaro, quien brindo su gentil colaboración en el diseño del proyecto y en la identificación de especies de Culicoides spp. capturados al igual que el Instituto de Ecología A.C (INECOL), Xalapa, Veracruz-México. Lugar donde realicé una estancia para la capacitación en sistematización de Culicoides spp. -
Discovery and Characterization of Bukakata Orbivirus (Reoviridae:Orbivirus), a Novel Virus from a Ugandan Bat
viruses Article Discovery and Characterization of Bukakata orbivirus (Reoviridae:Orbivirus), a Novel Virus from a Ugandan Bat Anna C. Fagre 1 , Justin S. Lee 1, Robert M. Kityo 2, Nicholas A. Bergren 1, Eric C. Mossel 3, Teddy Nakayiki 4, Betty Nalikka 2, Luke Nyakarahuka 4,5 , Amy T. Gilbert 6 , Julian Kerbis Peterhans 7, Mary B. Crabtree 3, Jonathan S. Towner 8 , Brian R. Amman 8, Tara K. Sealy 8, Amy J. Schuh 8,9 , Stuart T. Nichol 8, Julius J. Lutwama 4 , Barry R. Miller 3 and Rebekah C. Kading 1,3,* 1 Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA; [email protected] (A.C.F.); [email protected] (J.S.L.); [email protected] (N.A.B.) 2 Department of Zoology, Entomology and Fisheries Sciences, Makerere University, Kampala, Uganda; [email protected] (R.M.K.); [email protected] (B.N.) 3 Arboviral Diseases Branch, Division of Vector-borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80523, USA; [email protected] (E.C.M.); [email protected] (M.B.C.); [email protected] (B.R.M.) 4 Department of Arbovirology, Emerging, and Re-emerging Viral Infections, Uganda Virus Research Institute, Entebbe, Uganda; [email protected] (T.N.); [email protected] (L.N.); [email protected] (J.J.L.) 5 Department of Biosecurity, Ecosystems and Veterinary Public Health, Makerere University, Kampala, Uganda 6 National Wildlife Research Center, US Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, Fort Collins, -
Inhibition of Orbivirus Replication by Fluvastatin and Identification of The
viruses Article Inhibition of Orbivirus Replication by Fluvastatin and Identification of the Key Elements of the Mevalonate Pathway Involved Fauziah Mohd Jaafar 1, Baptiste Monsion 1 , Mourad Belhouchet 2, Peter P. C. Mertens 3 and Houssam Attoui 1,* 1 UMR Virologie 1161, INRAE, Ecole Nationale Vétérinaire d’Alfort, ANSES, Université Paris-Est, 94700 Maisons-Alfort, France; [email protected] (F.M.J.); [email protected] (B.M.) 2 Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, Oxford OX3 7BN, UK; [email protected] 3 Sutton Bonington Campus, School of Veterinary Medicine and Science, University of Nottingham, Leicestershire LE12 5RD, UK; [email protected] * Correspondence: [email protected] or [email protected]; Tel.: +33-143967007 Abstract: Statin derivatives can inhibit the replication of a range of viruses, including hepatitis C virus (HCV, Hepacivirus), dengue virus (Flavivirus), African swine fever virus (Asfarviridae) and poliovirus (Picornaviridae). We assess the antiviral effect of fluvastatin in cells infected with orbiviruses (bluetongue virus (BTV) and Great Island virus (GIV)). The synthesis of orbivirus outer-capsid protein VP2 (detected by confocal immunofluorescence imaging) was used to assess levels of virus replication, showing a reduction in fluvastatin-treated cells. A reduction in virus titres of ~1.7 log (98%) in fluvastatin-treated cells was detected by a plaque assay. We have previously identified a fourth Citation: Mohd Jaafar, F.; Monsion, non-structural protein (NS4) of BTV and GIV, showing that it interacts with lipid droplets in infected B.; Belhouchet, M.; Mertens, P.P.C.; cells. -
Viruses Status January 2013 FOEN/FOPH 2013 1
Classification of Organisms. Part 2: Viruses Status January 2013 FOEN/FOPH 2013 1 Authors: Prof. Dr. Riccardo Wittek, Dr. Karoline Dorsch-Häsler, Julia Link > Classification of Organisms Part 2: Viruses The classification of viruses was first published in 2005 and revised in 2010. Classification of Organisms. Part 2: Viruses Status January 2013 FOEN/FOPH 2013 2 Name Group Remarks Adenoviridae Aviadenovirus (Avian adenoviruses) Duck adenovirus 2 TEN Duck adenovirus 2 2 PM Fowl adenovirus A 2 Fowl adenovirus 1 (CELO, 112, Phelps) 2 PM Fowl adenovirus B 2 Fowl adenovirus 5 (340, TR22) 2 PM Fowl adenovirus C 2 Fowl adenovirus 10 (C-2B, M11, CFA20) 2 PM Fowl adenovirus 4 (KR-5, J-2) 2 PM Fowl adenovirus D 2 Fowl adenovirus 11 (380) 2 PM Fowl adenovirus 2 (GAL-1, 685, SR48) 2 PM Fowl adenovirus 3 (SR49, 75) 2 PM Fowl adenovirus 9 (A2, 90) 2 PM Fowl adenovirus E 2 Fowl adenovirus 6 (CR119, 168) 2 PM Fowl adenovirus 7 (YR36, X-11) 2 PM Fowl adenovirus 8a (TR59, T-8, CFA40) 2 PM Fowl adenovirus 8b (764, B3) 2 PM Goose adenovirus 2 Goose adenovirus 1-3 2 PM Pigeon adenovirus 2 PM TEN Turkey adenovirus 2 TEN Turkey adenovirus 1, 2 2 PM Mastadenovirus (Mammalian adenoviruses) Bovine adenovirus A 2 Bovine adenovirus 1 2 PM Bovine adenovirus B 2 Bovine adenovirus 3 2 PM Bovine adenovirus C 2 Bovine adenovirus 10 2 PM Canine adenovirus 2 Canine adenovirus 1,2 2 PM Caprine adenovirus 2 TEN Goat adenovirus 1, 2 2 PM Equine adenovirus A 2 Equine adenovirus 1 2 PM Equine adenovirus B 2 Equine adenovirus 2 2 PM Classification of Organisms. -
Full-Genome Characterisation of Orungo, Lebombo and Changuinola Viruses Provides Evidence for Co-Evolution of Orbiviruses with T
Full-genome characterisation of Orungo, Lebombo and Changuinola viruses provides evidence for co-evolution of orbiviruses with their arthropod vectors Fauziah Mohd Jaafar, Mourad Belhouchet, Manjunatha Belaganahalli, Robert B. Tesh, Peter P. C. Mertens, Houssam Attoui To cite this version: Fauziah Mohd Jaafar, Mourad Belhouchet, Manjunatha Belaganahalli, Robert B. Tesh, Peter P. C. Mertens, et al.. Full-genome characterisation of Orungo, Lebombo and Changuinola viruses provides evidence for co-evolution of orbiviruses with their arthropod vectors. PLoS ONE, Public Library of Science, 2014, 9 (1), 10.1371/journal.pone.0086392. hal-01606563 HAL Id: hal-01606563 https://hal.archives-ouvertes.fr/hal-01606563 Submitted on 27 May 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Distributed under a Creative Commons Attribution| 4.0 International License Full-Genome Characterisation of Orungo, Lebombo and Changuinola Viruses Provides Evidence for Co-Evolution of Orbiviruses with Their Arthropod Vectors Fauziah Mohd Jaafar1, Mourad Belhouchet1, Manjunatha Belaganahalli1, Robert B. Tesh2, Peter P. C. Mertens1, Houssam Attoui1* 1 Department of Vector-Borne Viral Diseases, The Pirbright Institute, Pirbright, United Kingdom, 2 Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America Abstract The complete genomes of Orungo virus (ORUV), Lebombo virus (LEBV) and Changuinola virus (CGLV) were sequenced, confirming that they each encode 11 distinct proteins (VP1-VP7 and NS1-NS4). -
CSIRO Latex Report Class
CSIRO HEALTH AND BIOSECURITY www.csiro.au Structured prioritisation of human and animal pathogens for the purpose of scoping risk assessments of genetic control strategies for malaria vectors in sub-Saharan Africa Final report Keith R. Hayes, David Peel, Debbie Eagles and Geoffrey R. Hosack June 30, 2020 Prepared for Stephanie James Foundation for the National Institutes of Health CSIRO Data61 GPO Box 1538, Hobart, Tasmania, 7001 Telephone : +61 3 62325260 Fax : +61 3 62325000 Copyright and disclaimer © CSIRO To the extent permitted by law, all rights are reserved and no part of this publica- tion covered by copyright may be reproduced or copied in any form or by any means except with the written permission of CSIRO. Important disclaimer CSIRO advises that the information contained in this publication comprises general state- ments based on scientific research. The reader is advised and needs to be aware that such information may be incomplete or unable to be used in any specific situation. No reliance or actions must therefore be made on that information without seeking prior expert profes- sional, scientific and technical advice. To the extent permitted by law, CSIRO (including its employees and consultants) excludes all liability to any person for any consequences, including but not limited to all losses, damages, costs, expenses and any other compen- sation, arising directly or indirectly from using this publication (in part or in whole) and any information or material contained in it. Contents ACKNOWLEDGEMENTS . 1 EXECUTIVE SUMMARY . 2 1 INTRODUCTION . 5 1.1 Project background and objectives . .6 1.2 Project scope and exposure pathways . -
Cell Culture Adapted Bluetongue Virus in Dogs Linn Arthur Wilbur Iowa State University
Iowa State University Capstones, Theses and Retrospective Theses and Dissertations Dissertations 1999 Cell culture adapted bluetongue virus in dogs Linn Arthur Wilbur Iowa State University Follow this and additional works at: https://lib.dr.iastate.edu/rtd Part of the Microbiology Commons, and the Veterinary Medicine Commons Recommended Citation Wilbur, Linn Arthur, "Cell culture adapted bluetongue virus in dogs " (1999). Retrospective Theses and Dissertations. 12493. https://lib.dr.iastate.edu/rtd/12493 This Dissertation is brought to you for free and open access by the Iowa State University Capstones, Theses and Dissertations at Iowa State University Digital Repository. It has been accepted for inclusion in Retrospective Theses and Dissertations by an authorized administrator of Iowa State University Digital Repository. For more information, please contact [email protected]. INFORMATION TO USERS This manuscript has been reproduced from the microfilm master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer. The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction. In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to t>e removed, a note will indicate the deletion. Oversize materials (e.g.. maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand comer and continuing from left to right in equal sections with small overiaps. -
Template for Taxonomic Proposal to the ICTV Executive Committee Creating Species in an Existing Genus
Template for Taxonomic Proposal to the ICTV Executive Committee Creating Species in an existing genus Code† To designate the following as species in the genus: 2007.137V.04 Orbivirus belonging to the family° : Reoviridae Yunnan orbivirus Yunnan orbivirus (YUOV) † Assigned by ICTV officers ° leave blank if inappropriate or in the case of an unassigned genus Author(s) with email address(es) of the Taxonomic Proposal Houssam Attoui, SG co-chair Reoviridae: [email protected] Peter Mertens, SG co-chair Reoviridae : [email protected] Old Taxonomic Order Order Family Reoviridae Genus Orbivirus Type Species Bluetongue virus Species in the genus African horsesickness virus Bluetongue virus Changuinola virus Chenuda virus Chogar Gorge Corriparta virus Epizootic hemorrhagic disease virus Equine encephalosis virus Eubenangee virus Ieri virus Great Island virus Lebombo virus Orungo virus Peruvian horse sickness virus Palyam virus St Croix River virus Umatilla virus Wad Medani virus Wallal virus Warrego virus Wongorr virus Tentative Species in the Genus Andasimbe virus Codajas virus Ife virus Itupiranga virus Japanaut virus Kammavanpettai virus Lake Clarendon virus Matucare virus Tembe virus Tracambe virus Yunnan orbivirus Unassigned Species in the Family New Taxonomic Order Order Family Reoviridae Genus Orbivirus Type Species Bluetongue virus Species in the genus African horsesickness virus Bluetongue virus Changuinola virus Chenuda virus Chogar Gorge Corriparta virus Epizootic hemorrhagic disease virus Equine encephalosis virus Eubenangee -
Template for Taxonomic Proposal to the ICTV Executive Committee Creating Species in an Existing Genus
Template for Taxonomic Proposal to the ICTV Executive Committee Creating Species in an existing genus Code† FT2003.121V.01 To designate the following viruses as species in the genus: Orbivirus belonging to the family° : Reoviridae Peruvian horse sickness virus (PHSV) † Assigned by ICTV officers ° leave blank if inappropriate or in the case of an unassigned genus Author(s) with email address(es) of the Taxonomic Proposal Peter Mertens, SG chair Reoviridae "peter mertens (IAH-P)" [email protected] New Taxonomic Order Order Family Reoviridae Genus Orbivirus Type Species Bluetongue virus List of Species in the genus African horsesickness virus Bluetongue virus Changuinola virus Chenuda virus Chogar Gorge Corriparta virus Epizootic hemorrhagic disease virus Equine encephalosis virus Eubenangee virus Ieri virus Great Island virus Lebombo virus Orungo virus Palyam virus Peruvian horse sickness virus St Croix River virus Umatilla virus Wad Medani virus Wallal virus Warrego virus Wongorr virus List of Tentative Species in the Genus Andasimbe virus Codajas virus Ife virus Itupiranga virus Japanaut virus Kammavanpettai virus Lake Clarendon virus Matucare virus Tembe virus Tracambe virus Yunnan orbivirus List of Unassigned Species in the Family (Fungal viruses) Rosellina necatrix mycoreovirus (proposed) Argumentation to justify the designation of new species in the genus Species demarcation criteria in the genus In common with the other genera within the family Reoviridae, the prime determinant for inclusion of virus isolates within a single Orbivirus species is compatibility for reassortment of genome segments during co-infection, thereby exchanging genetic information and generating viable progeny virus strains. However, data providing direct evidence of segment reassortment between isolates is limited and serological comparisons (primarily involving the immunodominant serogroup/species specific antigen VP7(T13)), form the usual basis of diagnostic assays for each of the virus species (serogroups). -
I Secretaria De Agricultura E Abastecimento Do Estado De São Paulo Agência Paulista De Tecnologia Dos Agronegócios Instituto
i Secretaria de Agricultura e Abastecimento do Estado de São Paulo Agência Paulista de Tecnologia dos Agronegócios Instituto Biológico Programa de Pós-Graduação em Sanidade, Segurança Alimentar e Ambiental no Agronegócio Prevalência e caracterização espacial de sorotipos do vírus da língua azul em bovinos, São Paulo, Brasil, 2011 Thaís Garcia da Silva Tese apresentada para a obtenção do título de Doutora em Sanidade, Segurança Alimentar e Ambiental no Agronegócio. Área de concentração: Segurança Alimentar e Sanidade no Agroecossistema. São Paulo 2017 ii Thaís Garcia da Silva Prevalência e caracterização espacial de sorotipos do vírus da língua azul em bovinos, São Paulo, Brasil, 2011 Tese apresentada para a obtenção do título de Doutora em Sanidade, Segurança Alimentar e Ambiental no Agronegócio. Área de concentração: Segurança Alimentar e Sanidade no Agroecossistema. Orientadora: Profa. Dra. Edviges Maristela Pituco iii Eu, Thaís Garcia da Silva, autorizo o Instituto Biológico (IB-APTA), da Secretaria de Agricultura e Abastecimento do Estado de São Paulo, a disponibilizar gratuitamente e sem ressarcimento dos direitos autorias, o presente trabalho acadêmico, de minha autoria, no portal, biblioteca digital, catálogo eletrônico ou qualquer outra plataforma eletrônica do IB para fins de leitura, estudo, pesquisa e/ou impressão pela Internet desde que citada a fonte. Assinatura: _______________________________ Data 05/ 07/ 2017 Dados Internacionais de Catalogação na Publicação (CIP) Secretaria de Agricultura e Abastecimento do Estado de São Paulo Núcleo de Informação e Documentação – IB Silva, Thaís Garcia da. Prevalência e caracterização espacial de sorotipos do vírus da língua em bovinos, São Paulo, Brasil, 2011. / Thais Garcia da Silva. - São Paulo, 2017. 121 p. -
Qualitative and Quantitative Assessment of the “Dangerous
Center for International and Security Studies at Maryland1 Qualitative and Quantitative Assessment of the “Dangerous Activities” Categories Jens H. Kuhn July 2005 CISSM School of Public Policy This paper was prepared as part of the Advanced Methods of Cooperative Security Program at the Center 4113 Van Munching Hall for International and Security Studies at Maryland, with generous support from the MacArthur Foundation University of Maryland and the Sloan Foundation. College Park, MD 20742 Tel: (301) 405-7601 [email protected] 2 QUALITATIVE AND QUANTITATIVE ASSESSMENT OF THE “DANGEROUS ACTIVITIES” CATEGORIES DEFINED BY THE CISSM CONTROLLING DANGEROUS PATHOGENS PROJECT WORKING PAPER (July 31, 2005) Jens H. Kuhn, MD, ScD (Med. Sci.), MS (Biochem.) Contact Address: New England Primate Research Center Department of Microbiology and Molecular Genetics Harvard Medical School 1 Pine Hill Drive Southborough, MA 01772-9102, USA Phone: (508) 786-3326 Fax: (508) 786-3317 Email: [email protected] 3 OBJECTIVE The Controlling Dangerous Pathogens Project of the Center for International Security Studies at Maryland (CISSM) outlines a prototype oversight system for ongoing microbiological research to control its possible misapplication. This so-called Biological Research Security System (BRSS) foresees the creation of regional, national, and international oversight bodies that review, approve, or reject those proposed microbiological research projects that would fit three BRSS-defined categories: Potentially Dangerous Activities (PDA), Moderately Dangerous Activities (MDA), and Extremely Dangerous Activities (EDA). It is the objective of this working paper to assess these categories qualitatively and quantitatively. To do so, published US research of the years 2000-present (early- to mid-2005) will be screened for science reports that would have fallen under the proposed oversight system had it existed already.