(12) Patent Application Publication (10) Pub. No.: US 2004/0110734 A1 Sackeyflo Et Al
US 2004O110734A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2004/0110734 A1 Sackeyflo et al. (43) Pub. Date: Jun. 10, 2004 (54) COMBINATIONS FOR THE TREATMENT OF (22) Filed: Nov. 19, 2003 NFLAMMATORY DISORDERS Related U.S. Application Data (76) Inventors: Robyn Sackeyflo, Ann Arbor, MI (US); Jason Fong, Philadelphia, PA (US); (63) Continuation of application No. 10/191,149, filed on Nicole Hurst, Boston, MA (US); Jul. 9, 2002. Palaniyandi Manivasakam, Brighton, MA (US); Edward Roydon Jost-Price, (60) Provisional application No. 60/304,089, filed on Jul. West Roxbury, MA (US); Grant 9, 2001. Zimmermann, Somerville, MA (US); Curtis Keith, Boston, MA (US); Alexis Publication Classification Borisy, Boston, MA (US) 51)1) Int. Cl.Cl." ..................... A61K 31/573573; A61K 31/553;55 Correspondence Address: A61K 31/554 CLARK & ELBING LLP (52) U.S. Cl. ..................... 514/171; 514/221; 514/211.13 101 FEDERAL STREET BOSTON, MA 02110 (US) (57) ABSTRACT The invention features methods and compositions for the (21) Appl. No.: 10/716,823 treatment of immunonflammatory disorders. US 2004/0110734 A1 Jun. 10, 2004 COMBINATIONS FOR THE TREATMENT OF SUMMARY OF THE INVENTION NFLAMMATORY DISORDERS 0008 We have discovered that the combination of amox CROSS-REFERENCE TO RELATED apine (2-cloro-11(1-piperazinyl)dibenzb,f1,4oxapine) APPLICATIONS and prednisolone (also known as 1-dehydrocortisol, 1-de 0001. This application is a continuation of U.S. Utility hydrohydrocortisone; 1,4-pregnadiene-11beta, 17alpha,21 application Ser. No. 10/191,149, filed Jul. 9, 2002, which triol-3,20-dione; and 11beta, 17alpha,21-trihydroxy-1,4- claims the benefit of U.S.
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