Selected Mast Cell Disorder Medical and Scientific References
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The Mastocytosis Society, Inc. Selected References-February, 2017 www.tmsforacure.org SELECTED MAST CELL DISORDER MEDICAL AND SCIENTIFIC REFERENCES FILE DESCRIPTION: This file contains selected references that might be of interest to mast cell disorder patients, their caregivers, physicians or others. Although efforts were made to compile a list of references containing information on a variety of topics related to mast cell disorders and mast cells, this is NOT a complete list of all articles available on these subjects. All references were obtained through searches of the PubMed database (http://www.ncbi.nlm.nih.gov/pubmed/) from the US National Library of Medicine, National Institutes of Health. If abstracts and hyperlinks to PubMed pages were available, they were also included in this file. Additional individually relevant references can be obtained by searching the PubMed database at the link provided above. DISCLAIMER: An effort was made to present a variety of opinions when considering inclusion of a reference for this file. Listing of an article in this file does not imply TMS support of its authors or contents and an article that is not listed in this file does not imply a lack of support of its authors or contents. Patients should consult with their doctors, or, if necessary, mast cell specialists, regarding any questions or concerns related to applicability, accuracy and individual usefulness of information presented in these articles. All references and abstracts in this file were obtained from the PubMed database of the US National Library of Medicine, National Institutes of Health (http://www.ncbi.nlm.nih.gov/pubmed). Consult your physician regarding any application of information contained within this document! www.tmsforacure.org The Mastocytosis Society, Inc. Selected References-February, 2017 HOW TO USE THIS FILE Searching: Use the “Find” box in your pdf file viewer to search for terms of interest or specific authors. You can also use the “Find” box to search for a group of terms (e.g., “mast cell activation”) or to search for references that contain a portion of a word (e.g., searching for “child” will bring up references that include terms such as “children” and “childhood”). When using the “Find” function, you can either use the “Enter” key on your keyboard, or the “Forward” icon (near the “Find” button on the Task Bar) to progress through the records identified in your search. Browsing: If you are simply interested in viewing the selected references published in recent years, the file is organized by publication year, and then by first author (in Z - A order). PubMed Links: Links to a given article’s PubMed listing are also provided, when available. The PubMed listing of an article generally has additional information on author affiliations. LINKS TO FULL TEXT FILES (SOME OF WHICH ARE FREE) CAN USUALLY BE FOUND IN THE UPPER RIGHT CORNER OF THE ARTICLE’S LISTING ON THE PUBMED WEBSITE. 1. Zanoni G, Zanotti R, Schena D, Sabbadini C, Opri R, Bonadonna P. Vaccination Management In Children and Adults With Mastocytosis. Clin. Exp. Allergy. Jan 12 2017. http://www.ncbi.nlm.nih.gov/pubmed/28079293 Mastocytosis includes a heterogeneous group of disorders characterized by the presence of clonal mast cells (MC) in cutaneous tissues and extracutaneous organs [1,2]. The disease presents in two primary age-related patterns, which may differ in their clinical manifestations and prognosis [1,2]. Pediatric-onset mastocytosis usually consists of cutaneous disease and tends to resolve itself by adolescence in most cases, in contrast to adult-onset mastocytosis which has a normal chronic course [2]. 2. Theoharides TC. Neuroendocrinology of mast cells: Challenges and Controversies. Exp. Dermatol. Jan 17 2017. http://www.ncbi.nlm.nih.gov/pubmed/28094875 All references and abstracts in this file were obtained from the PubMed database of the US National Library of Medicine, National Institutes of Health (http://www.ncbi.nlm.nih.gov/pubmed). Consult your physician regarding any application of information contained within this document! www.tmsforacure.org The Mastocytosis Society, Inc. Selected References-February, 2017 Mast cells (MC) are hemopoietically-derived tissue immune cells that are ubiquitous in the body, including neuroendocrine organs such as the hypothalamus, pineal, pituitary, ovaries, pancreas and uterus where their action is not well understood. Mast cells have historically been associated with allergies because of their rich content of histamine and tryptase, but more recently with regulation of immunity and inflammation due their synthesis and release of numerous cytokines and chemokines. Mast cells are located perivascularly and express numerous receptors for diverse ligands such as allergens, pathogens, neurotransmitters, neuropeptides and hormones including acetylcholine, calcitonin gene-related peptide (CGRP), corticosteroids, corticotropin-releasing hormone (CRH), beta-endorphin, epinephrine, 17beta-estradiol, gonadotrophins, hemokinin-A (HKA), leptin, melatonin, neurotensin (NT), parathyroid hormone (PTH), substance P (SP) and vasoactive instestinal peptide (VIP). Moreover, MC can synthesize and release most of their neurohormonal triggers, including adrenocorticotropin hormone (ACTH), CRH, endorphins, HKA, leptin, melatonin, NT, SP and VIP. Animal experiments have shown that diencephalic MC increase in number during courting in doves, while stimulation of brain and nasal MC leads to activation of the hypothalamic-pituitary-adrenal (HPA) axis. Recent evidence indicates that MC reactivity exhibits diurnal variations and it is interesting that melatonin appears to regulate MC secretion. However, the way MC change their phenotype or secrete specific molecules selectively at different pathophysiological settings still remains unknown. Mast cells developed over 500 million years ago and may have served as the original prototype neuroimmunoendocrine cell and then evolved into a master regulator of such interactions, especially since most of the known diseases involve neuroinflammation that worsens with stress. This article is protected by copyright. All rights reserved. 3. Schuch A, Brockow K. Mastocytosis and Anaphylaxis. Immunol Allergy Clin North Am. Feb 2017;37(1):153-164. http://www.ncbi.nlm.nih.gov/pubmed/27886904 This article updates current knowledge on epidemiology, risk factors, triggers, and management of anaphylaxis in patients with mastocytosis. Hyperactive mast cells and higher number of effector mast cells are speculated to facilitate All references and abstracts in this file were obtained from the PubMed database of the US National Library of Medicine, National Institutes of Health (http://www.ncbi.nlm.nih.gov/pubmed). Consult your physician regarding any application of information contained within this document! www.tmsforacure.org The Mastocytosis Society, Inc. Selected References-February, 2017 anaphylaxis in this condition. In children, increased risk is limited to those with extensive skin involvement and high tryptase. In adults, manifestations of anaphylaxis are severe with high frequency of cardiovascular symptoms. Hymenoptera stings are the most common triggers for these reactions; however, idiopathic anaphylaxis and reactions to food or drugs occur. Patients with mastocytosis should be informed about risk of anaphylaxis and prescribing emergency self-medication and installing emergency preparedness before general anesthesia is considered. 4. Parente R, Pucino V, Magliacane D, Petraroli A, Loffredo S, Marone G, Triggiani M. Evaluation of vaccination safety in children with mastocytosis. Pediatr. Allergy Immunol. Feb 2017;28(1):93-95. http://www.ncbi.nlm.nih.gov/pubmed/27590431 5. Metcalfe DD, Mekori YA. Pathogenesis and Pathology of Mastocytosis. Annu Rev Pathol. Jan 24 2017;12:487-514. http://www.ncbi.nlm.nih.gov/pubmed/28135563 Systemic mastocytosis is a clonal disorder of mast cells that may variably present with characteristic skin lesions, episodes of mast cell mediator release, and disturbances of hematopoiesis. No curative therapy presently exists. Conventional management has relied on agents that antagonize mediators released by mast cells, inhibit mediator secretion, or modulate mast cell proliferation. Recent advances in the molecular understanding of the pathophysiology of systemic mastocytosis have provided new therapeutic considerations, including new and novel tyrosine kinase inhibitors. 6. Greiner G, Witzeneder N, Berger A, Schmetterer K, Eisenwort G, Schiefer AI, Roos S, Popow-Kraupp T, Mullauer L, Zuber J, Sexl V, Kenner L, Sperr WR, Valent P, Mayerhofer M, Hoermann G. CCL2 is a KIT D816V-dependent modulator of the bone marrow microenvironment in systemic mastocytosis. Blood. Jan 19 2017;129(3):371-382. http://www.ncbi.nlm.nih.gov/pubmed/27856463 All references and abstracts in this file were obtained from the PubMed database of the US National Library of Medicine, National Institutes of Health (http://www.ncbi.nlm.nih.gov/pubmed). Consult your physician regarding any application of information contained within this document! www.tmsforacure.org The Mastocytosis Society, Inc. Selected References-February, 2017 Systemic mastocytosis (SM) is characterized by abnormal accumulation of neoplastic mast cells harboring the activating KIT mutation D816V in the bone marrow and other internal organs. As found in other myeloproliferative neoplasms, increased production of profibrogenic and angiogenic cytokines and related alterations of the bone marrow microenvironment are