The Effect of Disorders and Drugs Which Affect Thrombosis on The
ISSN: 2643-3966 Sloop et al. Int Arch Cardiovasc Dis 2018, 2:012 Volume 2 | Issue 2 Open Access International Archives of Cardiovascular Diseases RESEARCH ARTICLE Why Atherothrombosis is in Principle a Hematologic Disease: The Effect of Disorders and Drugs which Affect Thrombosis on the De- velopment of Atherosclerotic Plaques Gregory D Sloop1*, Gheorghe Pop2, Joseph J Weidman3 and John A St Cyr4 1 Check for Associate Professor of Pathology, Idaho College of Osteopathic Medicine, Idaho, USA updates 2Clinical Cardiologist, Radboud University Medical Center, Nijmegen, The Netherlands 3Formerly of Thomas Jefferson University, Pennsylvania, USA 4Jacqmar, Minneapolis, Minnesota, USA *Corresponding author: Gregory D Sloop, MD, Associate Professor of Pathology, Idaho College of Osteopathic Medicine, 105 27th St S, Great Falls, MT 59401, 1401 E. Central Dr., Meridian, Idaho, 83642, USA inally proposed by the nineteenth century pathologist Abstract Carl von Rokitansky. In this paper, the authors review The authors hypothesize that thrombosis causes both the the process of thrombus organization and examine the complications of atherosclerosis as well as the underlying lesion, the atherosclerotic plaque. Atherosclerotic plaques evidence that flow abnormalities, hematologic abnor- develop from the organization of mural thrombi. In this process, malities and pharmaceuticals, all of which modify the circulating progenitor cells trapped within the thrombus risk of thrombosis, also affect atherogenesis (Figure 1). differentiate into myofibroblasts which synthesize collagen, The impact on atherogenesis of some of these factors and endothelial cells which form granulation tissue. Eventually, all or most of the thrombus is replaced by collagen. Thus, has not been widely appreciated. Many of these factors conditions and drugs which affect thrombosis also affect the foster atherothrombosis by increasing blood viscosity.
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