LEO Pharma Timeline 1914 1910 1926 1939-40 Operations 3 80 200+ in employees employees employees initiated The early days 1908-1929 Entering biotech 1930-1984

1908 1909 1912 1917 1923-25 1930 1936 1939-40 1945 1946-48 1949-51

Pharmacists LEO Pharmacy Albyl® is In the newly LEO Pharma LEO Pharma Heparin Heparin® is LEOPenicillin® Penicillin LEO Pharma Antons establishes a launched and established initiates insulin develops a extraction launched. is launched. production starts export of and August bacteriological remains the laboratories production and number of method is plants are pharmaceutical Kongsted and pharmaco- most popular Dr. Marie Krogh finances the hormone developed. August LEO Pharma established products. receive royal physiological painkiller in standardises development products. Kongsted is the first under licence privilege from laboratory. for digitalis, making and production passes away. company in Italy, Protaminsulphat King Frederik VIII decades. Digisolvin LEO® of insulin in the Some hormones His son-in-law outside of the Spain and LEO® is launched to operate LEO Here, the is the first 1920s. are extracted Knud UK and the US France. in 1951. Pharmacy, production of Danish drug to from the urine of Abildgaard, is to manufacture From 1949 to (Løveapoteket, sterile and be exported. In 1925, the insulin pregnant appointed CEO penicillin. The first bricks 1959, LEO originally standardized production is women. of LEO Pharma. for LEO Bottles being Pharma moves founded in preparations is transferred to The new life- Pharma’s new filled at LEO production 1620), in initiated, and an the independent LEO Pharma’s saving drug, is headquarters Pharma to the new Copenhagen, inhalatorium for Nordisk Insulin- price list now considered a are laid in headquarters Denmark, and respiratory laboratorium. contains medical miracle. Ballerup, in Ballerup, establish LEO patients is approx. 230 Denmark. Denmark. Pharma. established. The original LEO branded LEO Pharma products. Pharma logo is staff collects inspired by the urine on August Assyrian lions pushbikes Kongsted found in Nebu- Waiting room chadnezzar’s in the palace in inhalatorium August Kongsted Babylon situated above LEO Pharma’s head Anton 1870-1939 Antons LEO Pharma’s the LEO quarters in Ballerup, first location in Pharmacy Denmark Copenhagen, Denmark 1960 1958 1979 Operations in Operations in Operations the UK initiated France, Holland, in the Middle & new operations Ireland & Greece East initiated initiated initiated in Sweden

1962 1977 1983 1988 1958 Operations Operations Operations Operations 2500 in Norway in Belgium in Canada in Poland & employees initiated initiated initiated Asia initiated Global expansion 1985-2008

1956 1958 1962 1971 1973 1976 1978 1984 1985 1986 1987

LEO Rontyl® is Fucidin® is Pondocillin® is LEO Pharma LEO Pharma’s One-Alpha® is The LEO The D vitamin Fucidin® H is Fucicort® Pharma’s launched. launched. launched. research into Heparin launched. Foundation is analogue, launched. is launched. logo is vitamin D production established. calcipotriol, is registered Fucidin® is based The next new analogues plant in synthesized. Knud as the on fusidicacid, a generation of begins. Esbjerg, Abildgaard official new antibiotic penicillins is Denmark is passes away. trademark. substance derived launched. established. from the fungus LEO Pharma is Fusidium now fully owned coccineum, by the LEO discovered by LEO Foundation. Pharma scientists in 1959. In 1958, at the 50th anniversary of the company, Abildgaard is given a lion cub. Knud The lion is Abildgaard donated to the 1901-1986 Copenhagen Zoo. 1990 1992 1995 1997 2009 2011 Operations Operations Operations Operations Operations Operations in Finland in Germany in Spain in Portugal in the US, China in Italy, Turkey initiated initiated initiated initiated & Australia & South Korea initiated initiated

2010 Operations 1991 1994 1996 2001 2002 2003 in Brazil, Japan Operations 4250 Operations Operations Operations Operations & Mexico in Switzerland employees in Austria in Morocco in Algeria in Tunisia initiated initiated worldwide initiated initiated initiated initiated Focus on dermatology

1991 1994 1998 2000 2001 2002 2003 2005 2008 2009 2011

Daivonex®/ Daivonex® is An R&D LEO Pharma is LEO Pharma LEO Pharma Daivobet®/ Daivobet®/ Xamiol® LEO Pharma LEO Pharma Dovonex® and awarded the facility awarded an manages to changes the Dovobet® Dovobet® is is launched. reacquires introduces its Innohep® are prestigious state-of- environmental combine two Danish receives the approved in marketing new mission: launched. Belgian the-art award, unmixable company Confederation the US under Taclonex rights in the ‘We help pharmaceutical facilities is Københavns compounds: name from of Danish the name Scalp® Topical US. people award Prix built in Amt Miljøpris calcipotriol and Løvens Industries’ Taclonex®. Suspension achieve Galien. Ballerup. as well as King betametha- Kemiske Fabrik Product Award. approved in healthy skin’. Frederik IX’s sone dipro- to LEO the US. Award for pionate, and Pharma. Excellence in Daivobet®/ ILEO Pharma Export. Dovobet® is celebrates its launched. 100years anniversary.

LEO Pharma R&D facilities in Ballerup, Denmark 2017 2018 2019 LEO Pharma 5200 5500 builds R&D employees employees hub in China.

2012-13 2014 2015 2016 2017 2018 2019 2020

Picato® is LEO Pharma LEO Pharma Enstilar® is Kyntheum®, LEO Pharma LEO Pharma LEO Pharma’s launched. Open acquires launched. LEO Pharma’s acquires breaks ground pipeline is Innovation is dermatology first biologic Bayer’s for the new extended with established: a portfolio from LEO Pharma treatment for prescription Fucidin® Active IL-17 small- collaborative Astellas. enters biologics psoriasis, is dermatology Pharmaceutical molecule space created through launched business. Ingredient modulator. to explore LEO Pharma strategic production plant establishes LEO partnership with LEO Pharma partnerships in Ballerup, LEO Pharma Innovation Lab: AstraZeneca. passes and the latest Denmark. enters license pursuing digital revenue of research using agreement solutions to LEO Pharma more than some of LEO with Oneness help people establishes LEO DKK 10 billion Pharma’s Biotech and with skin Science & Tech for the first unique scientific Microbio resources. diseases. Hub in Boston: time. exploring Shanghai for cutting-edge FB825, a novel science and atopic Visualization technology dermatitis and of LEO opportunities asthma drug Pharma’s with relevance candidate. new API to dermatology. production plant in Ballerup, Denmark