www.investincotedazur.com Team Côte d’Azur assists you in: • Connecting to the business ecosystem • Finding the best site for your business CÔTE D’AZUR: • Recruiting your teams • Accessing public incentives where healthtech • Channeling your communication will change your life F,ree personalized, and confidential expertise www.investincotedazur.com

NICE, ÉCO-VALLÉE, SOPHIA ANTIPOLIS, , GRASSE

Contact: Patricia Lay, Head of Life Sciences & Cosmetics Projects [email protected]

Team Côte d’Azur, 400, Promenade des Anglais, BP 3185, 06204 Cedex 3 Tel: +33 4 92 17 51 51 - [email protected]

A joint initiative NVI Conseil september 2015 © Photos : NVI; Shutterstock, Freepik et © Inria / Photo Kaksonen CC Iconfinder Freepik Shutterstock, NVI; NVI Conseil september 2015 © Photos : + WELCOME TO THE HEALTHTECH TERRITORY The Côte d’Azur hosts 263 companies in HealthTech, 30 research laboratories with more than 100 research units. It is the 2nd French Region for Clinical Trials and the 2nd VAR French research area in life sciences.

3 areas of expertise: NICE Therapeutic targeting • Medical devices ÉCO-VALLÉE MENTON • Digital Health • Academic Research Institutions • IPMC • SATT SE NICE Research and Development Centers • CIU SANTE GRASSE • DIGITAL HEALTH LIVING LAB R&D health sciences • ICP • CAL project support SOPHIA • Face and Neck Institute • Secured Communicating • Rossetti Center of Health Science Solutions • Saint François city ANTIPOLIS • SILVER ECO

Research and Development Centers R&D health sciences project support • INNOVATION AND PROSPECTIVE IN HEALTH • CSTB EUROBIOMED CLUSTER INRIA • • CANNES

Academic Research Institutions • IRCAN • C3M • IBV Accelerate R&D EFFICIENCY JOIN AN IDEAL LOCATION + in a tech driven ecosystem + TO CONDUCT CLINICAL STUDIES Academic Research Institutions v v v • IPMC: Institute of Molecular and Cellular Pharmacology • IRCAN: Institute for Research on Cancer and Aging nd France conducts f reNCH region th • C3M: Mediterranean Center of Molecular Medicine 2 1/5 of clinical • INRIA: National Institute for Computer Science and Control for clinical trials: studies conducted The Alpes-Maritimes Department in France • IBV: The Institute of Biology Valrose of v v v are 10% • High quality of conducted in the • SATT SUD EST: Accelerator of Technology Transfer clinical studies MOST DENSE MOST DENSE MOST DENSE A DYNAMIC infrastructure LOCALA DYNAMIC in place LOCALA DYNAMIC Alpes -MLOCALaritimes 2ND FRENCH RESEARCH2ND inFRENCH the AREA w RESEARCH orld 2ND FRENCH AREA RESEARCH • Rigorous AREA procedures Department good for Research and DevelopmentMEDICAL NETWORK CentersMEDICAL NETWORKMEDICAL NETWORK •ECOSYSTEM High recruiting ECOSYSTEMpotential ECOSYSTEM2nd place in France* ND ND ND IN LIFE SCIENCESIN LIFE SCIENCESIN LIFE SCIENCES 2 FRENCH REGION2 FRENCH REGION2 FRENCH6,000 academicREGION researchers,6,000 academic researchers,6,000 academic researchers, • CIU SANTE: Center of Innovation and Applied Health Sciences *Sources: LEEM and CHU Nice FOR CLINICAL TRIALSFOR CLINICAL TRIALSFOR CLINICAL400 life scienceTRIALS companies400 life science companies400 life science companies • DIGITAL HEALTH LIVING LAB: 27 Delvalle • ICP: Claude Pompidou Institute TAKE ADVANTAGE OF A POSITIVE SYNERGY • CAL: Antoine Lacassagne Center + • Fcea and Neck Institute BETWEEN PRIVATE AND PUBLIC SECTORS • Rossetti Center of Health3 AREAS Sciences OF EXPERTISE3 AREAS OF EXPERTISE3 AREAS OF EXPERTISESUCCESSFUL LEADERS,SUCCESSFUL STARTUPS LEADERS, &SUCCESSFUL SPIN STARTUPSOFFS LEADERS, & SPIN STARTUPSOFFS & SPIN OFFS Saint François CITY • with posi- Therapeutic Therapeutic TherapeuticThe CÔ te d’Azur aims for excellence • CSTB: Scientific and MedicalTechnical devices Building Medical E-healthCenter devices MedicalE-health devices E-health tive synergy from both private and public sectors, technology targeting targeting targeting • France SILVER ECO: National Center of Health Sciences Reference transfer acceleration companies, magnets for competitive development, and incubators. These partnerships are the R&D health sciences project support engine that drives company growth.

• I nnovATIon & Prospective in Health Cluster Awd arde with the IDEX label (Initiatives of • Secured communicating solution: IoT world Excellence), the University of Côte d’Azur has the financial renowned cluster resources (58M€/year for 4 years) and the academic infras- tructure to conduct high-level research. • Eurobiomed: largest biotech cluster in the French region Source: UNSA enhance your innovation Interact with global leaders + with cutting edge expertise + Fast growth towards the future: the companies that are settling in the region today will be tomorrow’s market leaders.

Trhe transfe of research results has created Spin-off companies such as:

• TxCell (INSERM): specialisingInfectious in cellular diseases immunotherapies for Nutrition & metabolism cellular and molecular pharmacologytreating inflammatory diseases. Nutrition & metabolism Dermatology ophtalmology Digital health cellular biology immunology These start-ups foster and advance a business environment that Dermatology toxicology and toxicogenomics CNS diseases biochemistry boasts heavyweights such as: molecular genetics • Lundbeck, the Danish leader in central nervous system treat- Ophthalmology bioinformatics Cancer biomaterials ments, Infectious diseases Nutrition & metabolism cellular and molecular pharmacology IT (micro-electronics, telecom, •software) Galderma, which built the world’s largest dermatology R&D Digital health cellular biology immunology center (500 people) in Sophia Antipolis,Medical devices Infectious diseases CNS diseases cancer Medical devices toxicology and toxicogenomics Dermatology Virbac, the world’s 8th largest animalCNS diseases health company, biochemistry• molecular genetics• Laboratoires Genévrier, a specialist in rheumatology, gynaeco- Ophthalmology bioinformaticslogy and dermatology with the 1st CancerEuropean center for cell culture biomaterials IT (micro-electronics, telecom,therapy, software) Digital health , aInfectious Contract diseasesResearchMedical Organisation devices (CRO) speciali- “NotNutrition only are & metabolismthere a cellular and molecular pharmacology • Iris Pharma cellular biology sing in preclinical and clinical ophthalmic research. large number of 3D specialists immunology in Sophia Antipolis, but it is also Dermatology toxicology and toxicogenomics CNS diseases very easy to attract the world’s biochemistry “High quality of life,molecular Infectious genetics diseases Nutrition & metabolism top professionals.cellular and” molecular pharmacology Ophthalmology pleasant climate, internationalbioinformatics Cancer cellular biology biomaterials Gérard Milhiet immunologyenvironment, theIT (micro-electronics,airport, highly telecom, software) Digital health Dermatology Co-Founder and Chief Operating Officer toxicology and toxicogenomicsskilled labour: the Côte d’Azur CNS diseases Infectious diseases Nutrition & metabolism cellular and molecular pharmacology Medical devices Median Technologies biochemistry is a fantastic place.” molecular geneticsInfectiouscellular diseases biology Nutrition & metabolismOphthalmology cellular and molecular pharmacology bioinformatics immunology CancerInfectious diseases cellular biology biomaterialsBo Hilligsoe Nutrition & metabolismDermatology immunology cellular and moleculartoxicology pharmacology and toxicogenomics IT (micro-electronics,CEO Lund telecom,beck software) CNS diseases Digital health toxicology and toxicogenomics cellular biologybiochemistry Dermatology CNS diseases Medical devices biochemistry immunologymolecular genetics molecular genetics Infectious diseases Dermatology Ophthalmology toxicology and toxicogenomicsbioinformatics CNS diseases Nutrition & metabolismOphthalmology cellularbioinformatics and molecular pharmacologyCancer Cancer biomaterials biochemistrybiomaterials IT (micro-electronics, telecom,cellular software) molecular biologyIT (micro-electronics, genetics telecom, software) Digital health Digital health Medical devices Ophthalmology immunologybioinformatics Cancer Medical devices Dermatology toxicology and toxicogenomicsbiomaterials IT (micro-electronics, telecom, software) CNS diseases Digital health biochemistry Medical devices molecular genetics Ophthalmology bioinformatics Cancer biomaterials IT (micro-electronics, telecom, software) Digital health Medical devices 2M Ireland 0.75M Swtart-up EASIly ith OUR soft-landing solutions Finance your R&D With UK + 2.1M + 0M 0M «The most attractive R&D tax policy in the world»OECD • 27 Delvalle Canada Belgium Germany #Digital health #Medtech #Living lab #Experimentation 2.5M 110 FUNDRAISERS SINCE #Co-working @ Nice 5M  Business Pôle • Ontario 2010 RESULTING IN 222M 2M #ICT #SCS Cluster @ Sophia Antipolis 2M 25 , 000 110 FUNDRAISERS SINCE Austria ICT SPECIALISTS France • CEEI (European Business and Innovation Center) 25 , 000 Ireland 0.75M Ireland 0.75M 2010 RESULTING IN 222M 1.2M ICT SPECIALISTS 2.1M UK 2,500 R&D UK 0M #Acceleration programs #incubators @ Nice ÉcoVallée 2.1M 2,500 R&D 0M POSITIONS0M CREATED 0M • Innovagrasse POSITIONS CREATED IN 10 YEARS Canada IN 10Canada YEARS Germany Belgium Germany 4.05 BILLION 4.05 BILLION #aroma #cosmetics #biotech @ Grasse Belgium IN REVENUE IN REVENUE United States COMPANIES & 2.5M 0.9M 2.5M 5M 55% EXPORTS COMPANIES &  5M • Allianz Accelerator Ontario 21 , 775 EMPLOYEES 55% EXPORTS Ontario 1,710 Austria #bigdata #sportech @ Nice ÉcoVallée + Austria France France 21 , 775 EMPLOYEES 1.2M 1.2M Spain 1,710 • EIT Digital Accelerator #ICT #cloud #security #smart uses @ Sophia Antipolis United States United States 0.9M 0.9M • The Village by Crédit Agricole accelerator #digital Spain Spain #energy #health #finance @ Sophia Antipolis STARTUPS • Paca-Est incubator @ Nice ÉcoVallée and @ Sophia Antipolis 338 #1 REASON CREATED FOR GLOBAL LEADERS NET TAX CREDIT PER COMPANYBETWEEN 2012-2014(for € 11.33M R&D) TO LOCATE THEIR R&D NET TAX CREDIT PER COMPANY NET TAX CREDIT PER COMPANY IN SOPHIA ANTIPOLIS: WRITE OFF STARTUPS Very favorable UnfavorableVery favorable Unfavorable EXPERT TEAMS IN 338 Very favorable Unfavorable v Source: Business France / a simulation by Taj Firm (Deloite Touche Tohmatsu Limited 2011) successful startups & spin offs Source: Business France / a simulation by Taj Firm (Deloite Touche Tohmatsu Limited 2011) STRATEGIC IT SEGMENTS #1 REASON 30% Source: Business France / a simulation by Taj Firm (Deloitte Touche Tohmatsu Limited 2011) CREATED FOR GLOBAL LEADERS OF YOUR R&D EXPENSES UP TO 100M* BETWEEN 2012-2014 TO LOCATE THEIR R&D WITH FRANCE’S 2,700 STUDENTS & RESEARCH TAX CREDIT 800 RESEARCHERS IN SOPHIA ANTIPOLIS: *AND AN ADDITIONAL 5% FOR IN INFORMATION TECHNOLOGY ALL EXPENSES ABOVE €100M WRITE OFF EXPERT TEAMS IN v 114 FOREIGN OWNED COMPANIES IT STRATEGIC IT SEGMENTS TAKE ADVANTAGE OF 9,000 JOBS 30% CREATED SINCE 2000, INCL.  OF YOUR R&D EXPENSES MOST DENSE ND A DYNAMIC LOCAL PUBLIC FUNDING 2,500 JOBS 2 FRENCH RESEARCH AREA IN COLLABORATIVE R&D PROJECTS. UP TO 100M* DEDICATED TO R&D MEDICAL NETWORK ECOSYSTEM €307M IN PUBLIC SUBSIDIES HAVE BEEN 2,700 STUDENTS & IN LIFE SCIENCES 20 INTERNATIONALWITH AWARDS FRANCE’S 2ND FRENCH REGION CHANNELED THROUGH THE SCS CLUSTER TO 191 6,000 academic researchers, PROJECTS, ACCOUNTING FOR €1300 M OF R&D EXPENSES. IN THE PAST 5RESEARCH YEARS TAX CREDITEMPLOYING 7 , 363 PEOPLE 800 RESEARCHERS FOR CLINICAL TRIALS 400 life science companies *AND AN ADDITIONAL 5% FOR ALL EXPENSES ABOVE €100M IN INFORMATION TECHNOLOGY

114 FOREIGN OWNED COMPANIES IT TAKE ADVANTAGE OF 9,000 JOBS CREATED SINCE 2000, INCL. 3 AREAS OF EXPERTISE SUCCESSFUL LEADERS, STARTUPS & SPIN OFFS  PUBLIC FUNDING 2,500 JOBS IN COLLABORATIVE R&D PROJECTS. DEDICATED TO R&D Therapeutic Medical devices E-health €307M IN PUBLIC SUBSIDIES HAVE BEEN targeting CHANNELED THROUGH THE SCS CLUSTER TO 191 20 INTERNATIONAL AWARDS PROJECTS, ACCOUNTING FOR €1300 M OF R&D EXPENSES. IN THE PAST 5 YEARS EMPLOYING 7 , 363 PEOPLE € € €

+ Access Premium Office Space at an affordable price + The world IS ONLY 30mIn from your OFFICE Côte d’Azur offers premium offices with some of the most competitive rental prices in Europe - 4 times cheaper than Paris. STOCKHOLM

COPENHAGEN MOSCOW f lights/day: DUBLIN LONDON: 32 LONDON BRUSSELS NYC: 2 PARIS AmsterdamN YC:: 9H9 5MIN ZURICH VIENNA 3h 3h StockholmDUBAI:: 3 6H 15MIN 2h 2h MOSCOW: 3H 35MIN 1h ROME MADRID NICE 1h Montreal: LISBON 3 flightsNICE/Week ATHENS

+ ENJOY a unique lifestyle

+ E njoy easy foreIGN interactions With over 5 million foreign tourists, 100,000 foreign residents, 1138 foreign companies, 21 international = schools, and dozens CHOOSE CÔTE D’AZUR: of international media, Côte d’Azur promotes The place to be for a truly multi-cultural companies that want it all! environment.