2007 Annual Report a Note About the Cover Artist

The Life Raft Group 2007 Annual Report A note about the cover artist:

This picture is one of many stunning pieces of art from the collection of Rachel Gilbert. Rachel is a 21-year-old GIST patient from the United Kingdom. She has been living with GIST for almost seven years. She uses her art to channel beauty into the world to cope with her disease.

Dear Friends,

Since last year’s annual report much has happened. The Life Raft Group (LRG) continues to grow in size and complexity to match the needs of today’s GIST (Gastrointestinal Stromal Tumor) patient. Our program priority areas remain the same: Research, Information and Support, Patient Outreach and Assistance and Advocacy. However, in 2007, we expanded our capacity through innovative technologies and approaches to reach the evolving GIST community.

From a birds-eye view the Life Raft Group is a thriving young organization, its message reaching hundreds of thousands each year to help GIST patients and their loved ones in as many ways as possible. Here on the ground, the LRG is running a race against time, a relentless pursuit of survival. Faced with increasing cases of resistance to first-line treatment, the LRG continues its commitment to finding a cure through its work and funding the Resistance Research Project.

GIST is a rare cancer, but the struggle of cancer survivors is not uncommon in our world today. We will continue, with the help of our supporters, medical professionals and volunteers, to ensure that no one has to face GIST alone.

Stan Bunn Norman J. Scherzer President Executive Director

The Life Raft Group’s Major Program Ar-

To accomplish its mission, the Life Raft Group devotes its efforts to four major priority areas: Research, Advocacy, Information & Support, and GIST Outreach.

Research In 2006, the Life Raft Group (LRG) set forth with a strategic plan and a team of expert researchers on the pathway to the cure. What is unique about this? The LRG not only funds this research but manages and facilitates communications of eight of the world’s leading GIST researchers from six different institutions. Our innovative grant system dramatically reduces administrative costs, holds each re- searcher responsible for specific results and redirects funding when neces- sary.

This year marked the one year milestone for the LRG Resistance Research Project and although the cure is not yet in hand we are optimistic that it will soon be in sight. In 2008, we plan to obtain more funding for this project and expand the team to include other expert researchers. (Please see Fletcher’s report for more details.)

LRG GIST Patient Registry

The LRG maintains a unique patient registry, tracking patients’ medical status to allow us to provide information to GIST patients and caregivers. Timely knowledge and information are key to survival. All of our information comes directly from patients and caregivers. Using this data, we examine questions that are not A new way to bring patients being answered quickly WEBCASTS: the information they need. enough by current trials or not being examined at all. The Life Raft Group We monitor the latest treat- Ensuring that no one has to face GIST alone. ments for early indications of a response. We look for Living Well with Side Effects: treatment and response trends that can help our Please join The Life Raft Group and Monica Davey Clinical Research Nurse Coordinator members reach tomorrow’s Fox Chase Cancer Center cure. Since the LRG is not lim- A Guide to Side Effects Management ited by the design of traditional clinical trials, we have significantly increased flexibility over areas that we can examine. We are better able to follow patients over long periods of time and across institutional boundaries. Because the LRG was founded by patients and caregivers, we are in touch with the real life issues that come up on a daily basis. This connection allows us to track treatments and issues that are of concern to GIST patients today. In 2007, the LRG updated the 2004 Gleevec dosage study and revealed, for the first time, that patients on a higher dose of imatinib had significantly higher overall survival rates. By fully embracing the role of patient advocate, we have now become patient scientists changing the medical research environment.

Treatment and Surveillance

With a growing number of GIST patients looking for the next step in their treatment, we have strengthened our focus on rigorously tracking clinical trials and publishing monthly updates in the newsletter. The unique molecular targets for each trial are also listed so that patients are not repetitively trying similar drugs. The LRG continues to encourage patients to get mutational testing in order for their physicians to take advantage of that information when developing survival strategies. Through our internal research, we also examine trends and preliminary reports so that patients can make in- formed decisions about the future of their care.

Patient Representatives came together from every corner of Advocacy the world at the Patient Summit, Bad Nauheim, Germany. The LRG has be- The Bad Nauheim Declaration was born! come a formidable advocate for GIST patients. As we grow, so does our ability to help GIST patients. This year the LRG’s major efforts included the adoption of the Bad Nauheim Declaration, which aims to create a standard of care for all GIST patients in any healthcare system across the world so that all patients are treated equally. The LRG has also lobbied against the Medicare and Medicaid proposed restrictions limiting the use of drugs that treat anemia, a common side ef- fect of most cancer medications. In addition to our public advocacy work, the most important efforts we carry out are done case by case for patients with nowhere else to turn. Many times patients or their loved ones contact the LRG for help from countries all over the world. They are facing obstacles that range from not receiving their prescriptions on time to outright refusal of treatment by their own government agencies. Often, patients are in dire need of treatment but, because of poor health, do not qualify for a clinical trial. The LRG works with those patients to gain access to a drug that will help them survive. The LRG goes above and

beyond most patient organizations by stepping in as the patients’ true advocate, using every method possible from persuasion to confronta- tion, to make sure that patients get needed treatment.

Information & Support

The LRG is committed to providing information and support to the GIST community including patients, their families, friends and medical professionals. With growing resistance to first-line treatment prompting the development of so many new drugs, it is of utmost importance for everyone to stay up-to-date. This year the LRG focused on expanding our newsletter content; re- structuring our website with new content and a focus on making it more user-friendly; and developing more education materials to ad- dress specific needs such as navigating clinical trials. The LRG also em- ployed the use of webcasts as an educational tool. Webcasts allow The LRG produces attendees to go online and log on to important seminars such as pamphlets to help “Living Well with Side Effects: A Guide to Side Effects Management”; patients cope with “Mutational Testing: Broken Down”; “‘GIST’ the Basics” and many making decisions about their care. more. Through innovative technology, we have reached thousands of people in their very own homes. Webcasts are also stored in our new video library which is easily accessible on the LRG website. The LRG was born on the internet and continues to provide patient support through our pri- vate email community. This forum allows only GIST patients and caregivers to discuss sensitive topics and exchange ideas to support everyone’s quality of life.

GIST Outreach

In addition to the newsletter, webcasts, website and email community, the LRG fosters the development of local groups that meet in-person across the United States. This year alone we have added 11 new groups to our ever-growing list. We also work with international chapters and sister groups through the Global GIST Network which is funded by the LRG. This year we have added patient liaisons in Belgium, Lithuania, Thailand and Uruguay. These volunteers serve vital roles to help GIST patients with treatment issues specific to their countries. With the help of many outstanding volunteers distributing educational materials, hosting events and launching personal campaigns, we are able to cast a wider net to create awareness for this rare cancer. We began working on pharmacy outreach this year hoping to reach all those patients who are on prescription drugs that treat GIST. So far, we have developed a pilot collaboration with a national pharmacy chain which has disseminated information about GIST to all of their locations.

The LRG Resistance Research Progress Report GIST THERAPY RESISTANCE MECHANISMS YEAR 2 PROGRESS REPORT:

Dr. Fletcher Research to identify therapeutic methods that operate in synergy with Gleevec (imatinib) in achieving long-term remission and cure of GIST In the past year, LRG research funding has enabled progress in identifying novel treatment strategies for GIST. Despite the remarkable clinical responses to KIT and PDGFRA kinase inhibition, GIST clinical progression can occur even in individuals with spectacular initial response to imatinib. For this reason, LRG is committed to funding research programs to develop synergistic targeted therapies that counteract imatinib-resistance in GIST. In the past year, research progress was made by studying new treatment methods in GIST sur- gical specimens, GIST cell lines, and mouse models of GIST. The urgent aims in all these studies are to identify therapies that function synergistically with imatinib in destroying GIST cells.

Each of the funded scientists performs GIST research that is coordinated with the efforts of the other scientists in this LRG program. Great pains have been taken to enable collaboration while eliminating redundant research efforts, such that team achievements are emphasized. This rigorous approach will continue to maximize the LRG research productivity, and – specifically – identify treatment approaches that synergize with imatinib and other KIT kinase inhibitors in enabling a higher cure rate for patients with GIST.

It is hoped that additional research priorities can be supported during the next several years of LRG funding. In particular, there is urgent need for therapies that operate in synergy with imatinib by increasing GIST cell apoptosis. The LRG resistance effort would be well-served by encouraging more studies of GIST survival and apoptosis mechanisms.

The imatinib-resistance studies described here are essential to therapeutic progress in GIST. These studies will likely reveal that com- binations of GIST therapies are needed to consolidate initial remissions, forestall the emergence of clinical resistance, and lead to increased cure rates. At present, the LRG research program funds ten “priority” projects. Each of these projects has substantial, near-term potential for enabling development of novel GIST therapies. The Year 2 progress for each of these highest-priority projects is summarized below.

Oncogenic signaling mechanisms as novel therapeutic targets: These studies continue to highlight the crucial role of the PI3-K kinase protein in transmitting KIT and PDGFRA oncogenic signals in GIST cells. Specifically, the LRG research group have shown that a subtype of PI3-K, known as “catalytic alpha” is most relevant in GIST, and future studies will prioritize validations of new drugs that inhibit this particular PI3-K subtype. The LRG studies have also demonstrated several proteins that bind to KIT in GIST cells: one example is the protein kinase C theta protein, which in the next year will be evaluated as a novel therapeutic target in GIST.

Wildtype GIST: This project was suspended last year, because there were insufficient numbers of cases identified in the early months of the research program. Fortunately, substantial progress has been made in the past year, such that KIT/ PDGFRA wildtype GISTs, as identified by mutational analyses of paraffin sections, can be used to identify the biologic mechanisms responsible for KIT activation in these cases. The recent work has identified several kinases, beyond KIT or PDGFRA, that are found at high levels in the wildtype GISTs, and that might serve as additional therapeutic targets.

Primary Resistance: Some GISTs are caused by KIT or PDGFRA mutations that do not respond well to imatinib. Re- search progress in the past year has highlighted that alternate therapies, including sunitinib, sorafenib, and nilotinib can be effective against subsets of these imatinib-resistant primary mutations. In addition, some KIT kinase inhibitors have greater potency than imatinib against nonmutant KIT, and these inhibitors GIST Finding may be particularly effective against KIT/PDGFRA wildtype GISTs. the Cure Stable disease after imatinib: Stable disease, i.e. GIST cells that are suppressed but not killed by imatinib, remains a major problem for most people with inoperable GIST. The recent LRG- funded studies show that a variety of imatinib-resistance mutations can be found at low levels in such stable GIST cells, accounting for partial resistance to therapy. However, other cells persist in absence of such resistance mutations, and new therapies – particularly those which are highly effective in inducing GIST cell apoptosis – are needed, in conjunction with KIT kinase inhibitor drugs, to destroy those cells. Future studies will focus on identifying drugs for stable GIST, and developing highly sensitive assays that can detect treatment-resistance mutations in blood samples.

Secondary resistance mechanisms: Continued progress has been made in identifying drugs that can inhibit secondary imatinib-resistant mutations. In addition, novel and extremely sensitive assays have been developed to detect low-levels of imatinib (and other KIT kinase inhibitor) resistance mutations in GIST biopsy materials.

Kit Degradation: These studies have identified small molecule HSP90 inhibitors that are exceptionally effective against the KIT oncoproteins in GIST cells. Preliminary studies show that greater efficacy, particularly in mouse GIST assays, is obtained with the combination of HSP90 inhibitor and imatinib, compared to using either drug on its own. Future studies will further evaluate these treatment synergies, and will determine mechanisms of HSP90 inhibitor resistance in GIST.

Murine Models: The laboratories of Drs. Besmer and Rubin have continued to develop mice that develop GIST and are therefore useful in testing new GIST drugs. Additional progress has included development of mice with imatinib-resistant GISTs, which will provide a system to test drugs of potential benefit for individuals whose GISTs have progressed while receiving imatinib.

Resource Development (imatinib sensitive & resistant): Exceptional continued progress has been made in developing new immortal GIST cell lines and mouse xenografts, which are indispensable for testing GIST drugs. The LRG scientists have shown that these resources provide biologically faithful model of GISTs in humans, and as such are highly useful in screening studies to identify new GIST drugs. Additional cell lines have been developed that permit drug testing against the wide variety of KIT and PDGFRA mutations found in GIST. These collective resources are, without doubt, one of the great strengths of the LRG research consortium.

Pediatric GIST: Dr. Antonescu’s research group has continued to shed light on the biological differences between pediatric and adult GISTs. Studies in the past year have shown that the frequency of genetic syndromes, particularly the so-called “Carney’s Triad”, may be underestimated in children with GIST. A small subset of pediatric GISTs have biologic similarities with adult GISTs, and these tumors can be expected to respond better than others to imatinib. However, most pediatric GISTs have substantial biologic differences from adult GISTs, including a lack of KIT mutations. Activated KIT is nonetheless important in these KIT/PDGFRA-wildtype tumors, and lab studies suggest that newer-generation KIT kinase inhibitors, such as nilotinib, might be therapeutically useful in these pediatric wildtype GISTs.

Tissue Banks: The LRG central repository for frozen and paraffin-embedded GISTs sup- ports the collective research efforts in this program. These specimens are studied to identify novel oncogenic mechanisms in KIT/PDGFRA-wildtype GISTs, and to identify additional therapeutic targets in GISTs with KIT or PDGFRA mutations. The Life Raft Group

LIFE RAFT BOARD

Stan Bunn, President Mia Byrne Dr. Arnold Kwart Jerry Cudzil, Secretary-Treasurer Chris Carley Ray Montague John Poss, Fundraising Co-chair Jim Hughes Rodrigo Salas Robert Book Jerry Knapp, Fundraising Co-chair Silvia Steinhilber

VOLUNTEERS Mia Byrne Science Team Member: General Counsel: Newsletter Editor Emeritus: David Josephy Thomas Overley Richard Palmer Science Team Member: Accountant: Web Designer: Michael Josephy Kristi Rosenberg Joe Trzepla Science Team Member: Accounting Firm: Fundraising co-chairs: Rick Ware Mackey & Mackey John Poss & Gerald Knapp Science Team Member: Database Consultant: Science Team Member: Glenn Wishon Steven Rigg Jim Hughes List Manager: GIST REPRESENTATIVES

STATE: Illinois: Richard Kinzig New York: Dan Cunningham Alabama: Pat George Indiana: Robert Book North Carolina: Chuck Korte Arizona: Linda Martinez Kansas: Jim Toyne Ohio: Kaye Thompson Colorado: Jerry Call Maryland: Bonnie Emerson Oregon: Gail Mansfield California: Floyd Pothoven, Massachusetts: Janice Leary Pennsylvania: Kim Trout Martha Zielinski Michigan: Ellen Rosenthal South Carolina: Al Boyle Florida: Skip Ryan Missouri: Bob Tikkanen Tennessee: Alice Sulkowski Georgia: Pat Lemeshka Nevada: Erik Krauch Texas: Kerry Hammett Idaho: Janet Conley New Jersey: Anita Getler Washington: Deanne Snodgrass COUNTRY:

Australia: Katharine Kimball Iran: Negar Amirfarhad Norway: Jan Einar Moe Belgium: Kris Heyman Ireland: Carol Jones Poland: Stan Kulisz Bolivia: Virginia Ossio Israel: Ben Shtang Romania: Simona Ene Brazil: Alexandre Sakano Italy: Anna Costato Russia: Tanya Soldak Canada: David Josephy Kenya: Francis Kariuki Singapore: Yong Choo Sian China: Ruijia Mu Lithuania: Virginija Zukauskiene Switzerland: Ulrich Schnorf Colombia: Jaime Peralta Malaysia: Yong Choo Sian Thailand: Kittikhun Pornpakakul Costa Rica: Michael Josephy Mexico: Rodrigo Salas Turkey: Haver Tanbay France: Estelle LeCointe Netherlands: Contactgroep GIST U.K.: David Cook Germany: Markus Wartenberg

2007 Contributors

The Life Raft Group would Ulrich Schnorf Institute Ellen Rosenthal Lawrence Selkovits Broesche Family Foundation Tatana Sahanek like to express its deepest Anonymous Truclean Ghandikota Sanjay thanks to the donors whose Bristol-Meyers Squibb Co. J.Lefcourt Philanthropic Fund Lois & Willoughby Sheane generous support and part- Infinity Discovery Inc Texas State Bank Gerald & Ellen Sigal nership make our work possi- Joseph Smith & Sons Inc. Dublin's Pub John Skeele ble. We are grateful for the Ochsman Foundation Tilson Home Corp. Lula V. Southerland Robert Spar following contributions and Quintiles Transnational Corp. Alice Sulkowski grants received for 2007. To $1,000 - $4,999 Kelley Suwak see who some of these do- Dorothy Battles $500 - $999 Gene Thompson nations honored please go LP Houston Beazer Homes Texas David Allentuck Rao V. Upender Isadore Bergner Joe Aranda to www.liferaftgroup.org Larry S. White Robert Book John & Nancy Barclay Lori Lee White $100,000 & Above Kathryn Byrne Bruce Barclay Lawrence Wilson Novartis Pharmaceuticals Corp. Roger & Lucy Carter Marilyn Berman Pollans MD Mark & Bonnie Winnick Pfizer Inc. Karl Cerny Ann Brennan Lawrence J. Wolfson Wokie Onike David John R. Brimsek Christopher Wright $20,000 - $99,999 Margaret Z. Deutsch Terry H. Brooks Greg Yakim Stan Bunn David M Falk Georgia Caraway Danny R. Young Jerry Knapp Thomas C. Green LLC CCM Rodrigo Salas Dolores Hawkins Purnell & Joan Choppin Anonymous Julian Haydon Marshal L. Cole Nobie Haynie Anne E. Corbeille Philip & Lee Hixon Robert Crowley $10,000 - $19,999 Douglas Horst Doris Dallow Carlos & Liana Baldor Peter Kavaloski Jack Dimaio Jr. Chris Carley Austin H Kiplinger Stanley Drab Jerry Cudzil Jacky Lewkovich Cyril & Risa Drabinsky Jim Hughes Eddie Martin Scott Dudley Arnold Kwart MD Michael Miller Daniel & Jane Duhl Amgen Gary Noble Peter & Julianne Durant Citigroup Henry & Bobbie Offen Billie Ellis The Arbor Foundation Joe Partain Richard & Lois England Jeff Payson Noah Estrin $5,000 - $9,999 Nicole Polston Chris Flammia Chris Carley Lester Poretsky Lady Galin David & Maxine Clark Jerry Cudzil’s and Fernando Prudencio Stephen D Gardner Dale Couch Patrick Raynal Kenneth R. Gilman Maurice Lipnick John Poss’s Poker Doris S. Rosenthal Barry & Palmer Graham David Smith & Patricia Brady Tournaments raised Richard Sharlin Sylvia Greenberg TXL Mortgage Corp. Poss Gerald Stern Leo Halpert over $100,000 in 2007! Marietta & James Robinson Terin Vivian Sean Hyer Kurt Watzek David & Sherry Jeffery Castlerock Communities LP Randall S. Welsh Fritz R. Kahn ABI Brooklyn Homes Robert & Wanda Wigand Dennis & Mary Kane Dakota Blue Homes Silvia Williams-Steinhilber Richard J. Kinzig Deerwood Homes Cervelle Homes Dr.& Mrs.Marvin Korengold Lane Family Foundation Broesche Family Foundation George Kourpias llC. B.L.P. Congressional Bank Patricia G. Lewis Mr.Smith's of Georgetown Fox Goldberg Foundation Inc. Winifred Lynn Nuway Homes Texas Gradison Foundation Alan Madian Rappaport Management Co. Gulf & Basco L.P. Clinton Matter Ratner Family Foundation Hallmark Design Homes LP Valerie Matthews Seven Oaks Foundation Keryx Biopharmaceuticals,Inc. Glenn Miller TXL Mortgage Corp. Koteen Foundation Laurence H. Miller MD Wallen Associates Marion & Robert Rosenthal Jonathan Nash The Babble Ball Foundation Lori Nash Purcells Cove Social Club Triangle Community Foun- Steve Norwood dation Serguei & Eleonora Novikov David Smith and Pat Brady donate The Olender Foundation John Ramsey $250 - $499 stock each year in memory of their Betty & Roy Anderson good friends’ Jim and Marge Hughes’ Washington Brain & Spine Steve & Darlene Rigg daughter, Nancy Hughes Welsh (right). $250 - $499 (cont.) Stig Von Post Amelie B Burgunder George Downes Joan Angerer Marc Wasserman Jeannine D. Burky Charleen & William Duke Glen & Elizabeth Banks Richard & Toni White Troy & Janet Burns Elbert Duncan Jose Luis Berrios Peggy & David Wicker Lee J. Burstyn Marsha & Charles Dunn Jose Berrios Robert Wilkinson G.Ann Byrne Donald & Jenny Dunner Simon S. Chung Roselina Wong-Parlove Maria Byrne Peter Durant Elizabeth Colice Hans Wyss Jerry & Janet Conley Andrew Young Tim Coughlin Joseph & Anna Zappala Jack Dimaio, Jr. Anonymous Ann P. DiMisa Key Pharmacy & Home Health Care Robert A. Dooling Posner-Wallace Foundation Alexander Doudoumopoulos Washington Healthbeat

Robert L. Earl Robert & Jeanie Eller $100 - $249 Cindy Erhart Leonard I. Abel Eli & Andi Feinberg Morton Abramowitz Delle & Sarah Ferris Richard E. Abrams Peter Gilbert Florence Allentuck Jeff Gilstrap Anthony John Aloi Robert & Jeannie Greene Melvin G. Alper MD Maya Grinchenko Harvey & Cora Alter Albert & Linda Hinton Phillip Archunde Team Viva Carolina ran the Long Beach Reinhardt Jesse Brian J. Arling MD Marathon and raised over $10,000 in Russell & Cindy Kaye Michael Arons honor of Carolina Ponce Williams Diana Kearney Lydia Atkinson Lawrence Kraus Gregory Auger Evangelos A. Calamitsis Christine Echer Leo A. Legatski Morton Bahr Sue & Richard Camann Patricia Ehresmann Sidney A. Levy Connie Baney Albert J. Camut Daniel & Marina Ein Jerome P. Lewis Burton & Amelie Bank Gail Canning Ken & Judie Elder Robert Lipnick MD Sandi & Michael Banks Luis Cariaga Jeff & Pam Emerson Eilish Loughran Sandra S. Baraff Pety Cariaga Stephanie Emerson Lai Oy Louie Frank & Heather Barbara Christopher Cartzendafner Eleanor Falkenstern John W Maass Lawrence Baskir Stuart M. Chemtob Jessie & George Falkenstern George McInnis James Bass Harvey Cherner Betty Fatzie Daniel K. Meyers Harold & Gloria Baston Boris E. Cherney Cary Mark Feldman Markku & Birgit Miettinen Howard Bayewitz Giordano Chiaruttini Miriam R. Feldman Marc & Beth Mintz Jacqueline Becker Leonard & Phyllis Chorazy Joan Fitzgerald Ruijia Mu Grace Bedoya Thomas B. Christensen Nancy Fletcher Stephen Nechtow Richard Bellofatto Eleanor & Donald Clark Harold A. Forman Abbas Patni Paula & Barry Belman John N.Jr. Clark Glen Foster Seymour Perlin MD Betty Benjamin Michael F. Clayton Lucia & George Foster Donald & Rosine Perlman Paul & Joanne Benoit Chuck Clupper Richard K. Fox Deborah Reinhart Louis & Joan Berge Lara D. Coggin Glenn & Beth Franz Semyon & Rimma Reznik Joan Berkowitz David Cohen William G. Frederick Patricia Ricard Ugo & Carla Bertocci Marshall M. Cohen Robert Fried Gloria Richmond John Bigelow George F. Cole Johathon & Lynn Friendly Paula Roach Vettel MD Caryn & Ron Bittker Tom Colwell Sue Galler Kenneth Samet Stuart Marshall Bloch Jose Luis & Cecilia Contreras Enrique Garcia Michele Scheiperpeter Leah Blum John J. Cooney Beatriz Garcia Diane Schmitz Marjorie Bobholz Evelyn Horn Courtin Alyse Gart James & Pamela Seymour George & Stephanie Bogue Jack & Evelyn Courtin Frederick Geiger William & Ellen Shaw Fred & Laura Bond Susan K. Cowart Jay & Ruth Gerber Jacque Sierad Monica Bonifaz Maureen Culhane Joseph M. Girodanno Harold Silver Stuart Bonwit H.Greig Cummings Jr. Jeffrey M. Gitelman Horard Silverberg Andrew & Lisa Boschma Albert W. Currier Seymour Glanzer Richard Sorg Emily Bowden Howard & Arlene Danziger Robert & Sandra Glassman Henry & Sharon Starr Margaret Bowman Maria C. Davidson Simun Glavinic Mary Stowell Angela Boyter Anita Dekelbaum Peter F. Gold Richard N. Tager Nancy Brock Frank & Karyn Deparis Leonard & Roberta Goldstein Guy Thomas Gerald Brody Frank DeParis Richard Gordy Grant Thomas Pierre & Virginia Brosseau Pierre DeRaet Edward Grant Harold & Suzanne Tobes Kara Brown Antionette Dereska Donald R. Greeley Puppy Villarreal Barbara & John Buch JamesH. Derrington Howard T. Greeley Daniel J. Buck Ann Dixon Michael Green $100 - $249 (cont.) Thomas M. Keyes Donald & Jane O'Kieffe Maria Smith Monica Green Mildred Kinzig Vandoorn Ooms David Snider Howard Greenley Donald Kirk Roberta H. Ostar Gerald & Deanne Snodgrass Esther Guerrier Jean E Kirnan Donald K Palmer Katherine Somervell John & Marjorie Gustafson John J Klein J.Hardy Patten Robert & Frances Spar Neva Hageman Chuck & Peggy Korte Tina Paulsen Harald & Karin Spruch Rick & Sharon Hake Lee LaBorwit Paz Paz Gary R. Squires Marianne Hamann Bruce S. Lane Susan Pedersen Jeffry Stallsmith Linda Hammell Diana & John Lanza James Pegram Hugh Steinberger Patricia Hampel Ira Laster Jr. Rosemary Perkins Lawrence Steinman Linda Hampson Lawrence J Latto Theodore Peyser Reuben Sternfeld James L. Hanley Arthur. Lazarus Jr. Joe Pfeifer Margrete & Michael Stevens Russell R. Hansen J. Martin Lebowitz Thomas J. Phillips John Stinson Marcia Harrison David Levene Michael Phillips MD George W. Stockton Sr. Stanley Hartman B. Levin Jennifer Pierce Christi Stone Margaret Haverstick John A. Leyes Jonathan & Joan Pincus Alan & Jerlyn Stone Wilbert Hawkins Judith F Lifton Pam Pollard Harvey Stork Arthur Hawkins Diane M. Linden Diego Ponce Murray Strasberg Haiqiong He Clare Lindquist Ian & Judy Portnoy Cynthia R. Sugimoto Luis & Clara Heffess Donor & Linda Lion Stephen & Barbara Powers Janice Summers William A. Helseth Alexander J. Lipske Jr. George Preisinger Gerald Summers George Herhold Linda Lipson Rose & Richard Pridgen Alvin Tanenholz John & Sarah Herren Paul Liston Dennis Priebat John Tarantino Joseph Herson Joshua Lonsk Linda Puryear Valentin V. Tepordei John R. Hodgdon Donald Lubick M.L. Raphael Linda A. Thompson Stacy Hoffmann Janet Machuca Alan Rapoport Antonio Tijman Ronald E. Holtz Seth Mankin Andrea & Tob Mailler Ready Kittie Tomson Sandra Howard Halford Manningre Stanley S. Reines Patricia A. Tyson James Howard MD Timothy & Gail Mansfield Francis & Margaret Richetti Maria Vallin Norman Isaacson MD Hector Marin Nancy Ridgway Gustavo & Maria Vazquez Brian & Cheri Jarzynski FrankA Marino Cheri Rizer Paula Vettel Ann C. Johnson Stanley C. Marinoff Charles Roberts James Vlogianitis Carolyn Markowitz William A. Roberts lll Leland J. Volker William L. Marre Gary R. Rottmann Albert & Doris Wahl Paul J. Mason Jim & Alice Rudd Rick & Kathie Ware John G. McDavid Douglas Ryan Janice Watson Martin J. McDonnell Elaine Rys Carol Webb Rose McKnight Edwin Saa Ruth Weigand Col Efrain & Judy Medina Howard M. Sachar Susan Weigand-Smith Robert Melillo Emanuel Sadwin Steven J. Weiss Sander & Irene Mendelson Robert Saks Stephen & Madeline Weiss Anne M. Menotti Nestor & Beth Sanchez Charles Welch lll Sharon J. Metro Familia Sagredo Sanchez Rachel B. Whitted Sheila M. Meyer Ethel Schafter John W. Williams Sheldon Meyers W.Thomas Scheiber April Wilson Frank Midgley MD Shirley Scher Jacobs Irene Wing Devon Lee Miller Carol Schlesinger Victor & Susan Winocur Jeff & Robyn Miller Harold M. Schoolman Sandra Young Kari & Harry Miller Gayle & Scott Schulman John Young lll “I support the LRG James Mills Charles Schwartz Victor K Yu because the job they are Jack Minker C.Delores Scott Stella G. Zanoff doing is very valuable.” Timothy G Mischo May Ruth Seidel Heather Zdan Louise Mochel Stuart F. Seides MD Mark Zdan ~ Ulrich Schnorf Jan-Einar Moe Allegra Sensenig Robert Zich Switzerland Howard Monderer Larry B. Shagle Martha Zielinski Marilyn Montuori Kenneth Shapiro Holden Properties Salvatore Montuori Mervin & Ruby Shello CLK Construction Nolan E. Jones Chad & Kira Montuori William Sherman Digital Security William & Mary Jones Mary Fae Morrison Victor & Rhoda Shields Hasco Industrial Supply William Lewis Jones Tamara K. Mundy Anne Shuman KLC Enterprises Ed Karler Seishin Murahashi Victor & Beatrice Siegel Leasing Resources Arline & Irving Katz Joseph S. Musher Norma & Robert Siegel LRM Realty Jack & Evelyn Katz Beverly Nerenberg Karen Silverstein Merck Sharp & Dohme FCU G.Arnold & Linda Kaufman Howard & Deborah Nussbaum Maria Singson Paragon FDU Thomas J. Keary John & Janice O'Brien David G. Smith Sobel Shipping George T. Keefer Daniel F O'Keefe Dwight O. Smith Retire Inc. $100 - $249 (cont.) Fred & Helen Emert Runi Limary Chicago Tribune Foundation Allan & Ruth Falkenstern Ronna Lindeken Jekl Gourmet Sandwiches Mar y & Edward Farley Arne Lindström

Quin Family Foundation Estelle R. Feit Anonymous Arlene Finger Up to $49 Maria Antonia Fiorentino Marcy Anderson Pau & Sharon Fisk Morris M. Abrams $50 - $99 Sophia E. Fleischer Dianne Abruzzo Mark A. Abramson Cathy Forbes Marcus Acheson Richard Ackerman George Forbes William Adams MD Alston Ahern Denise Fourie Elliot J. Allentuck Virginia Anderson Miriam Fox-Newton Negar Amirfarhad Life Raft Staffers Elizabeth Braun, John Angerer Robert & Sylvia Frank Leonard J. Arzt William Angerer Erin Kristoff and Tricia McAleer Robert E. Fuhr Willis Ashton threw a ball to celebrate Trish’s Rita Archunde Velma K. Galblum Joan Bailey Bryan & Nancy Balke birthday and raised over $1,000 Elizabeth Gardner Cinde Baliton for the LRG’s Research! Frederic W. Bancroft Kimberly Giovani Alice J. Ballard Maria Barber Roberta Goldwater Susana Bardin Daniel Droy Charles Barbera Mauricio Gumucio Phillip C. Baridon Thomas & Ruth Dwyer Margaret Barton Mauricio Gumucio Leland C. Barrows Lindsey Eckhouse Marvin A. Becker MD Marianne F. Guran Frank Bash Wayne Edwards Walt Benson Henry & Kate Haas William Behrns Lisa Ehrhardt Marisel Bernal-Epstein George R. Hall Diane Benincasa Daniel & Rachelle Eifert Irene Bihr Fritz Amy Harlan Alan Bennett William M. Eisenberg Dieter & Eileen Blobaum Thomas & Donna Harris Morton Beroza Florence P. Elfant David G. Borenstein Elaine Hauptman Melvin & Judy Berreth George J. Ellis Richard C. Boys Jr. Kim R. Heinicka Aaron Blanchard Russel & Bonnie Emerson Barbara Brandwein Julie Heinicka Neal B. Bobys Gabriel Etcheverry Roland E. Brack Jodie Heinicka Dennis & Karen Boren James & Carol Etherton Robert Bragulla JanetK. Hendrickson Judie Bouldry Lillian Falk Susan Brazier MaryKay Hertlelin Cedar Bouta Elizabeth Falkenstern Carlos V. Brezina Gerald Herz Gail Tucker Boyar Mary E. Falkenstern Jean Brier Joan Hicks Marilynn C. Bright John L. Farley David MD Buck Carola Hoelscher-Egger Louis Brisky Nancy & Richard Farman Molly Byock Lorenz Hofmann Jeffery D. Brockway Gary & Liz Farmer Moira Caballero Rudy B. Horst Thomas M. Brown CLU Harvey S. Fenster DDS Geoffrey & Brooke Caldwell Julie & Rob Hutson John & Helen Burns Jose Fernandez John Calo Theodore & Beverly Ifft Robert Buzaitis Allan & Barbara Firestone James Cameron Erich Isaak Katie Campbell Barbara & Leo Fitzgerald William & Christina Campbell Sally Jandrall Mary Cardoso Roger-Guy Folly Paul & Mary Carlson Paul & Andrea Jolly Michelle Carle Jerome Footer DDS Irwin M. Chapman Herbert A. Jolovitz Anthony P. Cavallo Jr. Pablo Forns-Samso Barbara & Everett Charlier Lori Jones Amoz Chernoff Joseph Forster Rod Bender Charters Mary A. Juricek Axel & Karen Christiansen Linda Foster Arnold & Wanda Chiet Olgerts Karklins Glenn Churchill MaryJo Fox Allen E. Clapp Elissa & Larry Kaufman Louise Clouser Daniel & MaryJo Fox Mark Conley Warren Kaufman Joseph & Shirley Cohen Jocelyn Francois Mary Catherine Corr RuthAnn Kawko Samuel & Gertrude Cohen Mary Francois Kay & Maynard Creel Robert & Shirley Kemelhor Jan & Harry Cohen Don & Joan Franklin Jay S Creswell Jr. Victor Kesse Thomas & Karen Collins Esther M. Franklin Holly Crittenden Edward Killham Katherine Colwell Joan Freedman Joseph D. Crumlish Edward K Kimmel Dennis & Barb Andreas Cook Elmer & Jean Freeze Dennis E. Curtis Allison B Klein Paula K. Cooley Phillip J. Fulford Margaret Cytron Sheri Kluga Stephen & Paula Cooley Bryan Gabaldon Peter & Linda Dahl Dale & Sheri Kluga Daniel Cooper Lorraine Garcia-Gordon Ida & Yuda Dana Robert & Mary Klunder Melvin E. Cruser Patty Gardner Frances Davis Ralph Koehring Marissa Cunningham Robert Gaynes R. Denburg Patti Kolster Elizabeth Daly Thomas & Marland Gengler Elizabeth Dietz Richard Kraut William P. Davis Pat George Robert K. Dobbs Mark Kuehl Victor Dawson C.D. Stanley Gibberman Jane & Alan Dorfman Maryann Laccabue Peter & Jane Del Vecho Valerie Gilmore Ed & Michelle Dorrington Jeffrey & Kimberly Laird Dorothy Deriet Stephen & Nancy Glasser Albert Drayton Carol L. Lazrus Stephanie & Tim Diekemper Roger Goldberger Willaim & Carol Edelen Lynnette Lenihan Dorothy Dilts Rosalind Goldfarb Levitt PhD Rona Eisner Joseph A. Levin Ken & Sue Dombart Julie Goldman Laura Eldred Catherine Liesman Leonard A. Donatelli Ann Goodman Up to $49 (cont.) Sandra Laione Phillip Osterman Swechha Singh Bernice P. Gordon Heather Lambirth Thomas Overley Debora S. Smith William B. Gordon Carol Lange Jack & Diane Page James & Virginia Smith Lazar & Svetlana Gorenman Robert Lange Lawrence B. Patent Nina Smolyar Dolores Gralley Jame T Lantelme Brenda Payton Donna & Kevin Smyth Louis & Suzanne Greenwald Vincenza A. Laudo Thomas P. Perazzoli Helen Snyder Mary Grimes Harriet & Barnard Lebowitz Joanna M. Perez Douglas & Ann Southerland Philip Guarneschelli Robin Legere Angel Perez Jennifer & Daniel Spencer Bertha Guerrero Enid & Dennis Lehr Gwen & Marshall Perrewe Alex V. Stanevich MaryAnn Gunderson Vicki Claire Lessard Debbie Peterson Maxine Stanoff Lewis Elvira Gutierrez Eleanor Lewis Paul J. Pickett Herbert Steiner Richard E. Gwinn Archie J.L. Little Robert Pierson Rosalind Stern J. Robert Hall Veronica Lohan Virginia H. Pigeon Douglas Sternberg Robert G. Hare Elizabeth Lopez Susan Poe Joan M. Storm Michael L. Hart Kenneth Lundell Mark G. Pomar Tom Suiter Charlean Haywood Virginia Lynn John & Melissa Powers Lorraine & Michael Susini David R. Hearn Gloria R. Mackenzie Richard J. Pries Susanne Sutton Rudolph W. Heglas Alan R. Malasky Malcolm L Pritzker Marina Symcox Estelle Hein Jeanne Mancini Helene Rabinowitch Zonaida Tan Edward & Ellen Heinrich James Mancuso Carlene C. Rhea Rachel Tate Audrey Hendee Philip & Catherine Mappin Robert & Phyllis Rice Doug Taylor Joan M. Henry Larry Marble Rebecca Rieger Grace A. Ternosky Carol Henyecz William & Katie Martin Deborah Rinehart Kevin & Lisa Torpey Juan Herrera Renee Martinez C.J. Rivlin Susan Trevino Hans George Hirsch Fern Mayer Joseph & Margaret Roberts Whitley Tucker Joan C. Hirsh Janice Maynard Angelia Roberts Laura Turner Fred & Norma Hoffman Marilyn Van Dyke Denise Holley Ronald F. Venezia Ronald & Susan Honeycutt Carolien Verhoogt Sandra Hood Sudhakar P. Verma William A. Horn Marius Vogelfanger Eunice Howley Stephen & Patricia Walker Margaret Hughes Howard & Terry Walker Albert & Torvy Hurd Wendy Warren Gerald Huve Adam Weiss MaryLou M. Iho Patricia Williams Josephine J. Ivey Khaurontha Williams Wendy Jennis Eduardo Mazzi Judith Ann Rock Enid Wilson Rosalyn B Joffe Tricia McAleer Violet Rodgers Ernest Wilson Arden & Caroline Jones Sally McCarthy Karl Rogge William R. Wilson L.C .& Leslie Jong Anne McCarthy Luana & David Rohlin Raymond P. Wishner Michael Josephy Ron & Vicki McClelland Evelyn Romansky Sarah Wolfberg Karen Kanyok Ricki L. McKenzie Howard & Helen Rosen Harry Wolfson Albert Kapikian Froman & Etta Mehl Melvin & Nanette Ross Allen Wolpe Alex & Urszula Kassel Hadi Mehrsefat Lillian Roth Michele Wysocki Ellen Keifetz Stephanie Meis Eleanor T. Albert Rubenstein Peter & Joanna Yates Walter J. Kennevan Elizabeth Melendez Selma W. Rubin Ethel Yauch Barbara J. Kepple Jeffrey & Susan Mendelsberg Shelley Ruff HarryI Yaverbaum Mary Kerwin Victoria Mendoza Amy Russell Richard Yorke Bruce & Darlene Kijewski Leona Merrifield Barbara W. Russell Harold & Gail Young Allan K. Kirkpatrick Audrey Merry Shirley Russell Stephen Young Gary & Mary Kittle Jack & Donna Meyers Caryn Sanders-Marcus Tiffany Zimmer George J Klett Alan & Judy Miller Doris Sachs Peter & Judi Zimmerman Katie Kluga Ann G. Miller Frances Sarfaty TIPS America Inc. Peter & Nancy Kmet John & Betty Miller Kristine Scharrer CEW Advertising Paul & Cathy Knoop Robin J. Morris Linda H. Schatz Porters Antiques-Pam Galouch Joy Knopp Paul V. Mullen Erica Schecter Richard B.Dingman & Assoc.Inc S.Kalman Kolansky MD Marsha G. Mullera Hartmut Schneider Sister Seton Cunneen Trudy Kominus Lillian M. Murray Carole L. Schulman Anonymous Karen A Kopicko Elpidio Vergara Nacpil Malka Schwartz Wendy Jennis & Doug Mishkin Alfred & Alberta Kordell Maria Navarro Desi Serna Seymour Korn Mary Netting Stephen Shafritz Harold & Joan Krauthamer Elizabeth Norvell Lionel Shapiro *If you feel we have made any errors Kathleen Kraynak Herbert & Donn Nurick Jill Shepperd in disclosing this information please Mr.& Mrs.G. Krook Maudine Odilatu Mary-Ann Siegel contact us at : Evan R. Kwerel Donna Osborn Vivian Silver [email protected] Allocation of Funds for 2007 Total Expenditures $ 1,340,673.00

Allocation of Program Service Expenses

Allocation of Research Grant Awards for 2007 The Life Raft Group (LRG) is an organization that provides support, information and assistance to patients and families with a rare cancer called Gastrointestinal Stromal Tumor (GIST). The LRG achieves this by providing an online community for patients and caregivers, supporting local in-person meetings, patient education through monthly newsletters and webcasts, one-on-one patient consultations, and most importantly, managing a major research project to find the cure for GIST.

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Permit No. 465 465 No. Permit

Wayne, NJ 07470 07470 NJ Wayne, So. Hackensarck, NJ NJ Hackensarck, So.

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Suite 19 19 Suite

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40 Galesi Drive Drive Galesi 40

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