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Breeding Soybeans with a Robust Trait Pipeline

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Breeding Soybeans with a Robust Trait Pipeline Breeding Soybeans with a Robust Trait Pipeline Rick Leitz February 22, 2010 Monsanto Company 2009 Growing Season Review • The central US experienced one of the coolest and wettest summers on record • White mold in Illinois, Iowa, Indiana and Ohio White Mold Incidence Map Final Yield Data Confirms GenuityTM Roundup Ready 2 Yield® Soybean Delivers RELATIVE 1 – 4 MATURITIES► COMPARISONS: >40,000 APPROXIMATE BU/ CRE AC ADVANTAGE FOR ROUNDUP READY 2 3.6 YIELD: BUSHELS PER A PERCENT YIELD ADVANTAGE FOR ROUNDUP READY 2 7.1% YIELD1: GenuityTM Roundup Ready 2 Competitive Products with Yield® Roundup Ready® Trait Genuity Roundup Ready 2 Yield® 2009 Trials Combine For 7+ Percent Over Competitive Roundup Ready® in Three‐Year Summary Three year summary (2007-2009) of head-to-head comparisons between all Roundup Ready 2 Yield ® products available for sale in 2010, includes Class of 2009 and advancement Class of 2010 products versus national competitive Roundup Ready products as of November 21, 2009 1Source: Includes all breeding and commercial strip trial data. 2009 data includes maturity groups 1, 2, 3 and 4. All head‐to‐head comparisons are within +/‐ 0.4 day maturity. Data is weighted equally by year. Class of 2010 GenuityTM Roundup Ready 2 Yield® Advancements Deliver Outstanding Results GEOGRAPHIC BREAK‐DOWN: Advancement Class of 20101 GENUITYTM ROUNDUP READY 2 YIELD® ND/MN North 4.3 bu 83% wins MN West MN East 4.2 bu 3.87M bu 82% wins SD 80% wins (9%) 3.6 bu 1.9M 79% wins (2.5%)MI/OH IA West 10M IA East 4.5 bu 4.7 bu (13%) 4.2 bu WI/IL N. 81% wins Northeast NE East 81% wins 77% wins 3.8 bu 7.9 bu 9M 5.4M 3.6 bu 80% wins 92% wins (12%) (7%)IN North 71% wins IA South 4.4 bu 4.8 bu IL Central 79% wins 84% wins 4.0 bu 76% wins KY/S. IN/ MO/KS OH GENETIC BANDWIDTH AND East 4.0 bu DIVERSITY EXPANDS RAPIDLY 4.3 bu IL South 70% wins 5.6 bu 78% wins 81% wins 2009 <15 varieties 2010 >125 candidate varieties Delta West Delta East 5.23.4M bu 6.2 bu 2011 >1200 candidate varieties 77%(4%) wins 77% wins Advancement Class of 2010 represents Roundup Ready 2 Yield varieties to be deployed in their projected sales geographies. Comparisons are between Class of 2010 versus national competitive Roundup Ready products as of Nov. 21, 2009. Data includes breeding and commercial strip plot data. Seed treatments are equivalent in every individual head to head comparison. 1. Class of 2010 advancements represents Roundup Ready 2 Yield varieties to be deployed in their projected sales geographies. Comparisons are between Class of 2010 versus national competitive Roundup Ready products as of Nov. 21, 2009. Class of 2011 Genuity™ Roundup Ready 2 Yield® Soybeans Show Promise to Deliver Additional Advantage Versus Class of 2010 GenuityTM Roundup Ready 2 Yield® Breeding Pipeline 2011 >1200 candidate varieties . > 1.1bu/acre over Class of 2010 . > 59%Win Rate . > 28,000 Comparisons *Head to head comparisons from breeding trials between Class of 2011 candidates and Class of 2010 advancements as of Nov. 21, 2009. Soybean Pipeline Products Designed to Provide Additional Grower Benefits 2ND-GEN HIGHER YIELDING SOYBEANS HIGH-STEARATE SOYBEANS S0YBEAN-CYST NEMATODE RESISTANCE RUST –TOLERANT SOYBEANS APHID-RESISTANT SOYBEANS HIGHER YIELDING SOYBEANS DICAMBA TOLERANCE VISTIVE GOLD OMEGA-3 SOYBEANS 2010+ GENUITY™ ROUNDUP READY 2 YIELD® Commercialization Depends on Many Factors, Including Successful Conclusion of Regulatory Process Insect-Protected Genuity™ Roundup Ready 2 Yield® Advances to Phase 4, Ushering In International Soybean Trait Platform St. Helena de Goias, Brazil – January 2009 Roundup Ready Soybeans Insect-Protected Roundup Ready 2 Yield Soybeans Initial Yield Results 2008/2009 Crop Year Medium Insect Pressure - 5 Sites • Insecticide reduction • Weed-control system performance • 11% Yield improvement from Roundup Ready 2 Yield® and insect control trait Discovery Phase 1 Phase 2 Phase 3 Phase 4 Launch Proof of Concept Early Development Adv. Development Pre-Launch Dicamba-Tolerant Soybeans Expected to Provide the Most Effective Weed Management System . Improved weed control options with two modes- 2009 Southern Illinois University Trials of-action. Roundup plus dicamba provides excellent control of hard to control weeds and glyphosate- tolerant weeds. Low residues of dicamba and dicamba metabolites may simplify registration Non-treated Control Dicamba at 8 oz/A tank mixed with of dicamba for over-the- 22 oz/A of Roundup WeatherMax on RR2Y/dicamba-tolerant soybeans top use. Discovery Phase 1 Phase 2 Phase 3 Phase 4 Launch Proof of Concept Early Development Adv. Development Pre-Launch Higher-Yielding Soybeans Showed Improved Yield Across Five Seasons of Broad-Acre Yield Trials Higher-Yielding Soybeans Outperform Controls In North And South American Trials • Intrinsic yield 8 improvement through 7 insertion of key genes AGE 6 ANT 5 • Lead event shows an ADV Product 4 Concept average yield advantage Yield Benefit YIELD of 7 percent over (BU/ACRE) 3 Target Range controls in meta- 2 VERAGE analysis across 5 A 1 seasons of testing in 0 95 environments Season 1 Season 2 Season 3 Season 4 Season 5 Cross-Season Average LAS LAS US ‘07 US 08 US ‘09 Summary • Developing regulatory ‘07-’08 ‘08-’09 data for phase Locations 18 13 24 23 17 95 advancement % Win 67% 100% 87% 85% 82% 84% COLLABORATION WITH Discovery Phase 1 Phase 2 Phase 3 Phase 4 Launch Proof of Concept Early Development Adv. Development Pre-Launch SDA Omega 3 Soybean Oil Provides a Sustainable Source of Omega 3’s in Human Diet PRODUCT CONCEPT: • Provide consumer health benefit (cardiovascular) • Improve food product performance (taste and shelf life) • Preferred sustainable source of omega 3 in food (flexible supply) Fatty Acid Composition (%) 16:0 18:0 18:1 18:2 18:3 18:4ω3 Palmitic Stearic Oleic Linoleic Linolenic SDA Commodity Soy 11 4 24 52 8 0 11 4 20 24 10 Increase Omega-3 Key Food Applications • Oil Based Foods • Beverages • Dairy Products • Baked Goods • Snack Foods • Prepared Foods Discovery Phase 1 Phase 2 Phase 3 Phase 4 Launch Proof of Concept Early Development Adv. Development Pre-Launch SDA Omega-3 Soybean Oil Confirms Heart Health Benefits CLINICAL STUDY RESULTS SHOW CONVERSION TO HEART HEALTHY EPA 1.4 * 1.2 * 1 Presented at: American Heart Association Scientific 0.8 Sessions Nov. 14, SDA Omega-3 Soybean 2009 by Dr. William Harris oil for food applications 0.6 IN RED BLOOD CELLS A (bread, cereal bars, dairy 0.4 drinks, spreads, %EP eeks eeks eeks dressings) 0.2 Control 12 W Control 12 W Control 12 W 0 Soy Oil EPA Oil SDA Oil Diet Diet Diet *Per protocol population of 157 subjects; p<0.001 compared to soy oil control; SDA and EPA not different p=0.101 • Aquaculture and feed applications • SDA diet more than doubles heart healthy EPA levels compared to commodity soy • SDA diet exhibited a significant reduction in triglycerides (26-30% versus control for subjects with high baseline triglycerides within subjects with high baseline triglycerides) Discovery Phase 1 Phase 2 Phase 3 Phase 4 Launch Proof of Concept Early Development Adv. Development Pre-Launch SDA Omega 3 Hitting Food Application Targets SDA Omega 3 soybean oil flavor profile • SDA provides excellent flavor and outperforms alternative sources of Omega-3 shelf life in taste tests Total Off Flavor ‐ 12 months • SDA works in a broad variety of foods Granola Bars 7.5 from cereal bars to beverages and spreads • “We have a strong interest in Low Score evaluating SDA in foods based on Wins! 5.0 5.0 these impressive samples” 4.0 Food Company Feedback 3.5 3.5 Control SDA Flax Algal Fish Encapsulated Soy Soy Fish 0-15 Scale National Food Laboratory. Nut and Berry Granola Bar Sensory Results. July 2008. Vistive® Gold Soybeans Provide Low Saturated Fat, High Stability, Zero Trans Fat Oil for Food PRODUCT CONCEPT: Specified by Food Companies • Improve consumer health (reduce trans & sat fat) • Improve food product performance (increase oxidative stability) • Establish soybean oil as preferred domestic source (>20M acres potential) • Key applications: High Stability Frying, Snack Foods and Baked Goods Soybean Oil - Fatty Acid Composition (%) 16:0 18:0 18:1 18:2 18:3 Palmitic Stearic Oleic Linoleic Linolenic Commodity Soybean Oil 11 4 20 55 8 Benefits Reduce Saturates Increase Stability Reduce Trans Fat Discovery Phase 1 Phase 2 Phase 3 Phase 4 Launch Proof of Concept Early Development Adv. Development Pre-Launch Vistive® Gold Designed to Deliver Food Nutrition Benefits and Establish Consumer Platform French Fry Study 40 % Sat Fat & Trans Fat 35 Trans Fat in French Fries 30 15.7% • Designed to provide food companies a cost-effective 25 20 vegetable oil that enables Sat Fat 23.4% 0.6% TFA them to create new and better 15 + PERCENT 19.4% SFA food products that provide 10 0.8% TFA 0.3% TFA improved functional + + 5 13.4% SFA 13.2% SFA performance. 0 • Consumer health benefits Partial Gen I High Oleic Vistive® Hydro Vistive Low Lin Gold • High Oleic Soy Oil Soy Oil Canola Soy Oil • Lowers saturated fats Source: 2009 Merlin Development and Monsanto . Reduced saturated fat 43 percent and • Eliminates trans fat trans fat 98 percent in French fries . Enables Zero Trans Fat on nutrition facts Phase 4 and “Clean Labels” (no trans-fat, low Pre-Launch saturated fat) Questions? Thank you for your time!! .
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