Preliminary Phytochemical and Antimycobacterial Investigation of Some Selected Medicinal Plants of Endau Rompin, Johor, Malaysia
Journal of Science and Technology, Vol. 10 No. 2 (2018) p. 30-37 Preliminary Phytochemical and Antimycobacterial Investigation of Some Selected Medicinal Plants of Endau Rompin, Johor, Malaysia Shuaibu Babaji Sanusi*, Mohd Fadzelly Abu Bakar, Maryati Mohamed and Siti Fatimah Sabran Faculty of Applied Sciences and Technology, Universiti Tun Hussein Onn Malaysia (UTHM), Pagoh Educational Hub, 84600 Pagoh, Johor, Malaysia. Received 30 September 2017; accepted 27 February 2018; available online 1 August 2018 DOI: https://10.30880/jst.2018.10.02.005 Abstract: Tuberculosis (TB), the primary cause of morbidity and mortality globally is a great public health challenge especially in developing countries of Africa and Asia. Existing TB treatment involves multiple therapies and requires long duration leading to poor patient compliance. The local people of Kampung Peta, Endau Rompin claimed that local preparations of some plants are used in a TB symptoms treatment. Hence, there is need to validate the claim scientifically. Thus, the present study was designed to investigate the in vitro anti-mycobacterial properties and to screen the phytochemicals present in the extracts qualitatively. The medicinal plants were extracted using decoction and successive maceration. The disc diffusion assay was used to evaluate the anti-mycobacterial activity, and the extracts were subjected to qualitative phytochemical screening using standard chemical tests. The findings revealed that at 100 mg/ml concentration, the methanol extract of Nepenthes ampularia displayed largest inhibition zone (DIZ=18.67 ± 0.58), followed by ethyl acetate extract of N. ampularia (17.67 ± 1.15) and ethyl acetate extract of Musa gracilis (17.00 ± 1.00). The phytochemical investigation of these extracts showed the existence of tannins, flavonoids, alkaloids, terpenoids, saponins, and steroids.
[Show full text]