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Apresentação Do Powerpoint Por que falar de conduta científica? Prof. Maria Carlota Rosa Seminários do Programa de Linguística: Sobre Ética e Integridade na Formação de Pesquisadores - edição2017 Definindo “má conduta científica” Entende-se por má conduta científica toda conduta de um pesquisador que, por intenção ou negligência, transgrida os valores e princípios que definem a integridade ética da pesquisa científica e das relações entre pesquisadores [....]. A má conduta científica não se confunde com o erro científico cometido de boa fé nem com divergências honestas em matéria científica. (FAPESP, 2011) A violação da ética na pesquisa pode-se dar de modos diferentes e em estágios diferentes do trabalho, os mais frequentes resumidos na sigla FFP, iniciais das palavras • Fabricação; • Falsificação; • Plágio. 3 BIRD & DUSTIRA, 2000 Todas las ramas de la ciencia tienen sus falsarios. Sin embargo, los fraudes son más frecuentes en aquellas disciplinas relacionadas con la vida, quizás por la importancia crematística, la siempre difícil reproducibilidad por diferencias biológicas y por el componente emocional cuando se trata de tratamientos milagrosos, que oscurece el raciocinio de quienes se encuentran incluidos directamente, los pacientes estafados. Rama-Maceiras, Ingelmo Ingelmo, Fàbregas Julià & Hernández-Palazón 2009 Se um trabalho está publicado num periódico com avaliação por pares e alto fator de impacto (FI), o pressuposto é que deve ser bom, isto é, CONFIAMOS que deve, pelo menos: • ser inovador e relevante, • ter metodologia aceita, • fornecer evidências para a hipótese e • deve basear-se numa pesquisa executada sem violações da ética. in a community based on trust, how do you find a reasonable balance of trust and skepticism? Where are the lines? GUNSALUS & RENNIE [2015] A credibilidade de um trabalho científico 1º - Autoria: de quem é o trabalho? • Segundo a FAPESP (2011) 2.2.3. Em um trabalho científico, pressupõe-se que toda ideia ou formulação verbal, oral ou escrita, que seja nele utilizada e não seja evidentemente de domínio público na área de pesquisa em questão, seja uma contribuição original dos pesquisadores indicados como autores do trabalho. Se não for esse o caso, a ideia ou formulação deve ser expressamente creditada, no trabalho, a seus autores, independentemente de já ter sido por eles divulgada em trabalho científico. • Segundo a UFRJ (2015): [....] “a cessão de recursos infraestruturais ou financeiros para a realização Deve ser considerado de uma pesquisa autor de uma obra (laboratórios, equipamentos, insumos, materiais, recursos aquele que tiver dado humanos, apoio substancial institucional, etc.) não é contribuição condição suficiente para intelectual para sua uma indicação de autoria de trabalho resultante dessa elaboração. pesquisa”. FAPESP (2011) 2.2.2. Um trabalho científico que exponha resultados de pesquisa realizada em situação de conflito potencial de interesses [....] deve conter, de maneira clara e destacada, a declaração de existência desse conflito. De modo geral, o trabalho deve conter a indicação expressa de todas as fontes de apoio material, direto ou indireto, à realização e divulgação da pesquisa. El sistema peer review (revisión por pares) que emplean la mayoría de publicaciones científicas [….] no está diseñado para prevenir el fraude o detectarlo sino para identificar aquellas investigaciones más brillantes y proveer de un sistema de retroalimentación a los autores para mejorar la calidad y claridad de los manuscritos. Incluso publicaciones como Science no han podido eludir el fraude en alguno de sus artículos. También la revisión por expertos puede prestarse a actividades de mala práctica, que pueden llegar a ser fraudulentas: desde la crítica injusta a un trabajo de colegas competidores y el retraso injustificado en el proceso de una revisión, hasta la pura y simple apropiación de ideas ajenas para los trabajos propios. [….] cuando los editores detectan un artículo basado en datos fraudulentos, su obligación es publicar una corrección que advierta a la comunidad científica de este hecho. Así mismo, es responsabilidad de la revista intentar que los estudios basados en un artículo que se escapó a su control de calidad no lo sigan citando. Quatro exemplos da má prática científica cujas consequências podem afetar a decisão clínica 1. O caso Vioxx 2. O caso Scott Reuben (1958-) 3. O caso Júlio Cruz (1951-2005) 4. O caso Andrew Wakefield (1956-) Caso 2 – Scott Reuben (1958-), anestesiologista • Trabalhava no Baystate Medical Center (Springfield, MA) • Condenado em 2009 por fabricação de dados ao longo de 15 anos. • Quando eclodiu o escândalo, seus trabalhos tinham recebido cerca de 1200 citações. • editorial de Anesthesia & Analgesia em 2007 ressaltara que Reuben tinha estado na "forefront of redesigning pain management protocols" e caracterizou seus estudos como "carefully planned" e "meticulously documented" . En la mayoría de los ensayos clínicos, los fármacos evaluados eran analgésicos antiinflamatorios inhibidores selectivos de la enzima ciclooxigenasa 2 (COX-2) como rofecoxib, valdecoxib, celecoxib y parecoxib, y fármacos adyuvantes como el antidepresivo venlafaxina y el antiepiléptico pregabalina. RAMA-MACEIRAS, INGELMO INGELMO, FÀBREGAS JULIÀ & HERNÁNDEZ- PALAZÓN 2009 En mayo de 2008, se inició una auditoría interna dentro del BMC, cuando se Además de adulterar datos, el descubrió que el investigador no había Dr. Reuben parece haber solicitado permiso al Comité Ético cometido falsificación en la Asistencial del hospital para la realización publicación, ya que algunos de algunos de los estudios referidos. coautores como el Dr. Evan Como consecuencia de dicha auditoría, el Ekman, cirujano ortopédico, dijo Dr. Scott S. Reuben reconoció finalmente, que su nombre apareció como que los resultados aparecidos en 19 de coautor en al menos dos de los sus estudios y 2 resúmenes publicados artículos de los que las revistas [….], no eran consecuencia de la se han retractado, a pesar de aplicación de los tratamientos a pacientes que no había tenido ninguna reales, sino fruto de su invención y que participación en los manuscritos. los datos eran de su responsabilidad exclusiva RAMA-MACEIRAS, INGELMO INGELMO, FÀBREGAS JULIÀ & HERNÁNDEZ-PALAZÓN 2009 Dr. Reuben accepted a $75,000 grant from Pfizer to study Celebrex in 2005. His research, which was published in a medical journal, has since been quoted by hundreds of other doctors and researchers as "proof" that Celebrex helped reduce pain during post-surgical recovery. There's only one problem with all this: No patients were ever enrolled in the study! He also faked study data on Bextra and Vioxx drugs, reports the Wall Street Journal. Adams, 2010 BORNEMANN-CIMENTI, SZILAGYI & SANDNER-KIESLING (2015) Perpetuation of Retracted Publications Using the Example of the Scott S. Reuben Case: Incidences, Reasons and Possible Improvements Bornemann-Cimenti , Szilagyi & Sandner-Kiesling, 2015 In 2009, Scott S. Reuben was convicted of fabricating data, which lead to 25 of his publications being retracted. Although it is clear that the perpetuation of retracted articles negatively effects the appraisal of evidence, the extent to which retracted literature is cited had not previously been investigated. In this study, to better understand the perpetuation of discredited research, we examine the number of citations of Reuben’s articles within 5 years of their retraction. Citations of Reuben’s retracted articles were assessed using the Web of Science Core Collection (Thomson Reuters, NY) 3. Júlio Cruz (1951-2005) Médico brasileiro ganha prêmio internacional Método que permitiu salvar a vida de pacientes em coma grave rendeu ao neurocirurgião Julio Cruz o status de um dos 200 maiores intelectuais do mundo O médico brasileiro Julio Cruz, neurocirurgião e neurocientista, de 53 anos, recebeu a Order of Excellence do século 21, do Internacional Biographical Centre de Cambridge, na Inglaterra, o que lhe dá o status de um dos 200 maiores intelectuais do planeta de todas as áreas. A menção é para "aqueles, não só médicos, com publicações que mais contribuíram para a vida na Terra". Tudo isso porque Cruz comanda pesquisas que resultam em métodos para salvar pessoas que há até pouco tempo seriam consideradas casos de morte irreversível - e ainda lhes garantindo qualidade de vida. Entre 1988 e 2004, foram 55 publicações, em uma média de duas a três por ano, 45 delas à frente das pesquisas: é o maior currículo de neurocirurgia e terapia intensiva nas principais revistas internacionais da área, segundo a Medline, que reúne as publicações médicas existentes. Cruz J, Minoja G, Okuchi K. Improving clinical outcomes from acute subdural hematomas with the emergency preoperative administration of high doses of mannitol: a randomized trial. Neurosurgery. 2001;49(4):864-71. 102. Cruz J, Minoja G, Okuchi K. Major clinical and physiological benefits of early high doses of mannitol for intraparenchymal temporal lobe hemorrhages with abnormal pupillary widening: a randomized trial. Neurosurgery. 2002;51(3):628-37. 103. Cruz J, Minoja G, Okuchi K, Facco E. Successful use of the new highdose mannitol treatment in patients with Glasgow Coma Scale scores of 3 and bilateral abnormal pupillary widening: a randomized trial. J Neurosurg. 2004;100(3):376-83. Doubts over head injury studies Between 2001 and 2004, a Brazilian neurosurgeon Julio Cruz and colleagues published three clinical trials comparing high dose and conventional dose mannitol in the treatment of head injury (the results showed that high dose mannitol
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