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April 2012 -OMICS DATA VALID April 2012 -OMICS DATA ALSO INSIDE THIS ISSUE: Special events at the annual meeting Poetry contest winners American Society for Biochemistry and Molecular Biology AT0412_C2C1.indb 1 3/26/12 3:16 PM USB® ExoSAP-IT® reagent is the Original ExoSAP-IT gold standard for enzymatic PCR cleanup. reagent means Why take chances with imitations? 100% sample recovery of PCR products in one step 100% trusted results. Single-tube convenience Proprietary buffer formulation for superior performance Take a closer look at usb.affymetrix.com/exclusive © 2012 Affymetrix, Inc. All rights reserved. AT0412_C2C1.indb 2 3/26/12 3:17 PM contents APRIL 2012 On the cover: ASBMB Today science writer Rajendrani news Mukhopadhyay looks 3 President’s Message into how the mountains Evolution and molecular Lego of -omics data being produced should and 5 News from the Hill could be validated. 14 Hill Day 2012 6 The Capitol Hill cohort 8 FASEB Update 9 Member Update Headed to San Diego for the annual 10 Annual awards meeting? Find out 10 Herbert Tabor/JBC Lectureship winner about special events, 11 William C. Rose Award winner read the winning 12 Earl and Thressa Stadtman Scholar Award winner poetry contest entries and check out our 13 Ruth Kirschstein Diversity in Science Award winner list of recommended mobile apps to make feature your trip go smoothly. 14 Valid -omics 20 – 25 How should massive quantities of -omics data be validated? annual meeting 20 Special events and more 20 Fun run, mixers and programs 22 Science in stanzas: poetry contest results When Dennis Vance asked 24 Mobile apps and social media notes his students if they knew about Konrad Bloch, left, essay he wasn’t encouraged by 26 Tribute to midlevel scientists their responses. 27 departments 27 Lipid News Are we doing a good job of teaching the groundbreaking research of our predecessors? Sonia C. Flores offers step-by-step advice 28 Journal News for those new to the 28 JBC: Worm protein provides insight NIH grant-application into aging and neurodegeneration process. 30 28 JLR: How the only FDA-approved drug for primary biliary cirrhosis works in the liver 29 MCP: Serum antibodies as biomarkers 30 Minority Affairs Navigating the NIH grant-application process 32 Education onlineex clusiv Indications of a bright future through science We’re pleased to announce that science writer 34 Open Channels Rajendrani Mukhopadhyay now has a blog. 34 Letter to the president Follow her quips and queries at www.asbmb.org/asbmbtoday. 34 Response to ASBMB premed curriculum recommendations April 2012 ASBMB Today 1 AT0412_C2C1.indb 1 3/26/12 3:17 PM onlineex clusiv A monthly publication of www.asbmb.org/asbmbtoday The American Society for Biochemistry and Molecular Biology Offi cers Suzanne R. Pfeffer President Jeremy M. Berg President-Elect Research Mark A. Lemmon Secretary Merle S. Olson Treasurer Spotlight Toni M. Antalis Treasurer-Elect Council Members Read two “research spotlight” Karen N. Allen Ruma V. Banerjee interviews with Elizabeth Benjamin F. Cravatt Michael A. Marletta Ntantie (left), a pharmacology David Sabatini John D. Scott Melissa Starovasnik Wesley I. Sundquist graduate student at the Medi- Jonathan S. Weissman cal College of Wisconsin, and Ex-Offi cio Members with Casonyta Matese Johnson Russell DeBose-Boyd Hongtao Yu (right), an associate professor Co-chairs, 2012 Annual Meeting Program Committee of biology at Georgia State Uni- Peter J. Kennelly Chair, Education and Professional Development versity, by asBmB’s education Committee Joan W. Conaway and professional development Chair, Meetings Committee manager, Weiyi Zhao. Terri Kinzy Chair, Membership Committee Squire J. Booker Chair, Minority Affairs Committee Bettie Sue Masters Chair, Public Affairs Advisory Committee Charles Brenner Discovery through writing Chair, Publications Committee Want to know more about the scientists who won the Martha J. Fedor, Editor-in-chief, JBC ASBMB poetry contest being held in conjunction with Herbert Tabor, Co-editor, JBC Ralph A. Bradshaw Experimental Biology 2012? Make sure to visit A. L. Burlingame Co-editors, MCP our website to read their bios. You’ll also fi nd bios by the Edward A. Dennis contest judges— some serious and some not so much. Joseph L. Witztum Co-editors, JLR ASBMB Today Editorial Advisory Board Alex Toker (Chair) Mike Bradley Craig E. Cameron A. Stephen Dahms Alex C. Drohat ASBMB Today is Ben Ellington Irwin Fridovich Richard W. Hanson Gerald Hart Peter Kennelly Carol C. Shoulders now on Pinterest! ASBMB Today Join us at http://pinterest.com/asbmbtoday/. Angela Hopp Editor We’ve pinned all of our magazine covers [email protected] from the past 10 years. If you let us know Rajendrani Mukhopadhyay Sr. Science Writer / Editor which ones are your favorites, it’ll help [email protected] us plan future covers. Erin Salb Production Coordinator [email protected] Nancy J. Rodnan Director of Publications [email protected] Barbara Gordon Executive Director [email protected] For information on advertising, contact Capitol Media Solutions at 800-517-0610 or [email protected] www.asbmb.org/asbmbtoday April 2012 AT0412_C2C1.indb 2 3/26/12 3:17 PM president’smessage Evolution and molecular Lego BY SUZANNE PFEFFER ot far from the traffic and cacophony of downtown tion. I often have neglected to consider evolution when N Bangalore is a quiet, secluded compound that trying to understand the molecular basis of a given cel- houses India’s National Centre for Biological Sciences of lular process. Evolution adds an important dimension. the Tata Institute of Fundamental Research. Now in its “Bringing together molecular cell biologists, immunol- 20th year, this center of research excellence is powered ogists and evolutionary biologists who appeared ready by scientists studying biochemistry, biophysics and bio- to candidly discuss their favorite cellular processes and informatics; cellular organization and signaling; ecology structures and debate the origins of cellular compart- and evolution; genetics and development; neurobiol- ments and cellular immunity, in the context of new ideas ogy; and theory and simulation of biological systems. about genes and their capacity for evolution, was a risky I had the pleasure of visiting the NCBS in February to experiment for us as organizers of this conference,” said attend an international workshop and research confer- Mayor. “The quality of discussion and the fount of new ence titled “The Evolutionary Origins of Compartmental- ideas generated suggest that this experiment was wildly ized Cells.” India’s International Centre for Theoretical successful. This augers well for a bright future for the Sciences provided funding for the meeting as part of its exciting and emerging field of evolutionary cell biology.” mission to nucleate new areas of research by bringing Thattai echoed Mayor’s sentiments, saying, “One of together scientists from diverse fields. the great things about studying the evolution of cells The conference was organized by Frances Brod- is that no topic is off limits. Though ours was a diverse sky from the University of California at San Francisco, meeting by any standard, with topics ranging from together with Satyajit (Jitu) Mayor and Mukund Thattai organelle biology to phylogenetics to ancient viruses, from NCBS. Their goal was to bring together evolution- I found fascinating and relevant ideas to take away ary biologists, cell biologists and immunologists to try from every talk.” to synthesize what these disciplines can teach us about Brodsky added, “Molecular cell biologists inter- the origins of the first eukaryotic cell and the origin of ested in the evolutionary origins of pathways we study the human immune system. The conference taught me can learn a lot from immunologists who have refined an important lesson: Evolution of a biochemical process techniques to extract information from the co-evolution can teach us a great deal about how it operates— of host–pathogen interaction pathways, which are the it can help determine which features are fundamental most rapidly evolving in biology.” and which represent cellular or organismal specializa- I was invited to the conference because I share a common experience with one of the organizers, Brodsky. A manuscript referee once told each of us (independently) that the human proteins that we were describing couldn’t be relevant because that gene product is not pres- ent in mice (even though it was present in all other vertebrates). Some take the even more extreme The conference was organized by Frances Brodsky of the University of California at San Francisco, Satyajit (Jitu) Mayor, center, and Mukund Thattai from India’s National Centre for view that if we understand Biological Sciences. a process in yeast it is not April 2012 ASBMB Today 3 AT0412_C2C1.indb 3 3/26/12 3:17 PM fipresident’s rsts ondmesscontinued age continued worth studying in humans because we already under- energize us, stimulate new ideas and catalyze the dis- stand the fundamentals. covery of novel connections between diverse proteins, This cannot be correct: We need to understand the pathways or systems. regulation of human pathways that will differ in different This month, ASBMB holds its annual meeting in San cell types, tissues and/or developmental stages. Many Diego, and we are also sponsoring a number of mem- diseases can be attributed to proteins that are found ber-initiated, smaller meetings on a variety of topics. We only in humans and for which the genes represent encourage you to help identify cutting-edge, interdisci- duplication and diversifi cation to yield traits needed plinary topics for consideration for ASBMB-sponsored for our complex physiology. Thus, the study of human special symposia and/or annual meeting themes for next cells and tissues is important; the study of nonhuman year and beyond. In the meantime, I look forward to see- organisms and pathogens is also important. When we ing you in San Diego! see convergent evolution provide the same solution to a complex problem, we have a better understanding of ASBMB President Suzanne Pfeffer (pfeffer@ its importance.
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