Genetic and Historical Migration Relationship of Three Northern Sabah 51 Genetic and Historical Migration Relationships of Three Northern Sabah Native Ethnic Groups with Their Southern China and Southeast Asia Neighbours C. W. Yew1, M.Z.Hoque2, J. Pugh-Kitingan3, C.L.Y. Voo1, J. Rangsangan4, S.T.Y. Lau1, X. Wang5, W. Y. Saw5, T. H. Ong5, Y. Y. Teo5, S.H. Xu6, B.P. Hoh7, M.E. Phipps8 and S.V. Kumar1* 1Biotechnology Research Institute, 2School of Medicine, 3School of Social Science, 4Borneo Marine Research Institute, Universiti Malaysia Sabah, Jalan UMS, 88400 Kota Kinabalu, Sabah, Malaysia. 5Department of Statistics and Applied Probability, National University of Singapore, Singapore. 6Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China. 7Institute for Molecular Medical Biotechnology, Universiti Teknologi MARA, Malaysia. 8Jeffrey Cheah School of Medicine and Health Sciences, Monash University, Malaysia *Email:
[email protected] Abstract The native ethnic groups of Sabah are divided into Dusunic, Paitanic and Murutic-speaking groups under the North Borneo stock of the Austronesian linguistic family. As this region is a putative entry and transition point of the ‘Out-of-Taiwan’ human migration history, the founder effect may have created multiple new ethnic groups. Nevertheless, there is no evidence to support this hypothesis as the population structure and genetic relationships of the indigenous ethnic groups in Sabah and with those in Southeast Asia and Southern China regions are unknown. As such, this study aims to unravel and compare the population structure and genetic relationships of the Northern Borneo populations against the regional populations, for subsequent inference of migration history.