Rabbit Anti-Human APEH Polyclonal antibody (DPABH-23563) This product is for research use only and is not intended for diagnostic use.
PRODUCT INFORMATION
Immunogen AARE fusion protein, sequence: AQRSRQDLFAVDTQVGTVTSLTAGGSGGSWKLLTIDQDLMVAQFSTPSLPPTLKVGFLPSAGKE QSVLWVSLEEAEPIPDIHWGIRVLQPPPEQENVQYAGLDFEAILLQPGSPPDKTQVPMVVMPHG GPHSSFVTAWMLFPAMLCKMGFAVLLVNYRGSTGFGQDSILSLPGNVGHQDVKDVQFAVEQVL QEEHFDASHVALMGGSHGGFISCHLIGQYPETYRACVARNPVINIASMLGSTDIPDWCVVEAGF PFSSDCLPDLSVWAEMLDKSPIRYIPQVKTPLLLMLGQEDRRVPFKQGMEYYRALKTRNVPVRL LLYPKSTHALSEVEVESDSFMNAVLWLRTHLGS (381-732aa encoded by BC000362)
Isotype IgG
Source/Host Rabbit
Species Reactivity Human, Mouse, Rat
Purification Antigen affinity purification
Conjugate Unconjugated
Applications WB, IHC, ELISA
Positive Control mouse liver tissue, COLO 320 cells, HeLa cells, Jurkat cells
Format Liquid
Size 50 uL; 100 uL
Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Preservative 0.02% Sodium Azide
Storage Store at -20°C. Aliquoting is unnecessary for -20°C storage.
BACKGROUND
Introduction This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino
45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]
Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma.
Keywords APEH; acylaminoacyl-peptide hydrolase; APH; OPH; AARE; ACPH; D3S48E; D3F15S2; DNF15S2; acylamino-acid-releasing enzyme; acyl-peptide hydrolase; acylaminoacyl-peptidase; oxidized protein hydrolase; N-acylaminoacyl-peptide hydrolase;
GENE INFORMATION
Entrez Gene ID 327
UniProt ID A0A024R2U9
45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]
Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved