THE HELEN HAY WHITNEY FOUNDATION

2012-2013 Annual Report

20 Squadron Boulevard, Suite 630 New City, NY 10956 www.hhwf.org Tel: (845) 639-6799 Fax: (845) 639-6798 THE HELEN HAY WHITNEY FOUNDATION

BOARD OF TRUSTEES

Averil Payson Meyer, President Steven C. Harrison, Ph.D., Vice President Lisa A. Steiner, M.D., Vice President W. Perry Welch, Treasurer Thomas M. Jessell, Ph.D. Payne W. Middleton Thomas P. Sakmar, M.D. Stephen C. Sherrill Jerome Gross, M.D., Trustee Emeritus

SCIENTIFIC ADVISORY COMMITTEE

Steven C. Harrison, Ph.D., Chairman David J. Anderson, Ph.D. Daniel Kahne, Ph.D. , Ph.D. Markus Meister, Ph.D. Barbara J. Meyer, Ph.D. Matthew D. Scharff, M.D. Julie A. Theriot, Ph.D. Jonathan S. Weissman, Ph.D. S. Lawrence Zipursky, Ph.D.

ADMINISTRATIVE DIRECTOR and SECRETARY

Robert Weinberger

Page 1 of 29 REPORT OF THE VICE PRESIDENT AND CHAIRMAN, SCIENTIFIC ADVISORY COMMITTEE

The past two years have been eventful ones. The generosity of the Simons Foundation has allowed us to increase by three the number of fellows we select each year, giving us a class of about 24. Tom Jessell, a former SAC member and now a Trustee, was instrumental in helping us approach the Simons Foundation, which has an extremely interesting overall plan for support of frontier biomedical research and with which I can foresee more extensive interactions going forward.

We also increased by one the number of SAC members, to enhance coverage in fields such as systems neuroscience and mathematical modeling, in which we have received applications that have challenged the expertise of the eight-member group. I was delighted when everyone's first choice, Markus Meister, Professor of at Caltech, accepted our invitation with little hesitation. Markus studies neuronal circuits, with the goal of identifying the computation performed by a particular circuit (e.g., in the olfactory bulb or the retina), working out the mechanism behind this computation, and explaining how this circuit fits into the larger context of a brain.

Shortly after Markus came on board, Erin O'Shea stepped down from the SAC when she accepted the position of Chief Scientific Officer at the Howard Hughes Medical Institute. Erin's experience and expertise in fields that range from structural biology and to systems biology and biology have brought wisdom to our discussions, and her focused and no-nonsense view of evaluations and decisions will be huge assets in her responsibilities at HHMI, as they have been for us. Jonathan Weissman, Professor of Cellular and Molecular Pharmacology at UCSF, who agreed to join the SAC in time for the 2013 selection cycle, is the ideal person to bring comparable breadth and wisdom. Jonathan has devised powerful and elegant tools to probe the systems biology of a cell by exploiting his deep insights about molecular mechanism, based in part on his discoveries in such fields as folding and prion biology.

Matthew Scharff, the longest standing member of the SAC, decided to step down at the end of the 2013 selection cycle. Matty, a distinguished immunologist, has brought perspective to our deliberations in an area of great traditional strength among Helen Hay Whitney Fellows. Fortunately, another very distinguished immunologist, Philippa Marrack, of National Jewish Health in Denver, well known for her work on T-cell development and on identifying the T- cell receptor, is our most recently appointed member. I have admired Pippa's approach to scientific questions and scientific judgments for many years, and I look forward to more regular encounters.

The Annual Meeting continues to be a high point of Foundation activities. Participation in these meetings allows Fellows working at different institutions to get to know each other and builds a sense of community that lasts well beyond the three years of their appointment. Robert Weinberger organizes that meeting, and indeed all of our efforts, with remarkable effectiveness and attention to detail. Almost without exception, the acknowledgment slides in the presentations from third-year Fellows at the Annual Meeting include a generous and well deserved recognition of Robert's contribution. In their statements of gratitude, they also speak for the SAC.

Stephen C. Harrison, Ph.D. Page 2 of 29

ORGANIZATION

The Foundation was established and endowed by Mrs. Charles S. Payson, the former Joan Whitney, in 1947, and named in honor of her mother, Helen Hay Whitney. The current Postdoctoral Research Fellowship Program was begun in 1956.

The Foundation is a New York State not-for-profit corporation. The corporation elects a Board of Trustees of not more than eleven members at its annual meeting. Full power in the management and control of the affairs of the corporation is vested in this Board, which holds two stated meetings a year. An Executive Committee acts for the Board in the intervals between meetings.

The Postdoctoral Research Fellowship Program is the responsibility of the Scientific Advisory Committee and is under its continual review and evaluation. The day-to-day administration of the fellowship program is the responsibility of the Administrative Director, who reports to the Chairman of the Scientific Advisory Committee.

PURPOSE

The Foundation was established to stimulate and support research in the area of rheumatic fever and rheumatic heart disease, later expanding its interests to include diseases of connective tissue and, ultimately, all basic biomedical sciences. Under the Foundation’s program, young men and women planning careers in biological or medical research receive financial support of sufficient duration to help further their professional careers. Residents of the , Canada, and Mexico who hold the M.D., Ph.D., or equivalent degree, or US citizens residing abroad, are eligible to apply for a fellowship for beginning postdoctoral training in biomedical research.

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THE WALTER BAUER MEMORIAL MEETING

The Annual meeting of Fellows is held in November each year, and at this meeting each third-year Fellow speaks on the results of his or her research during the tenure of the fellowship. The Foundation also invites a distinguished scientist to present the Maclyn McCarty Annual Lecture.

The Fifty-Fifth Annual Fellows Meeting was held at the MIT Endicott House, November 2-4, 2012, with 56 current Fellows in attendance as well as the Scientific Advisory Committee, members of the Board of Trustees, and the Administrative Director. There were 18 presentations by the Fellows in their final year of fellowship support. Jack W. Szostak, Ph.D., Professor of Genetics at Harvard Medical School, Professor of Chemistry and Chemical Biology at Harvard University, and Alexander Rich Distinguished Investigator at Massachusetts General Hospital, presented the Maclyn McCarty lecture.

The Fifty-Sixth Annual Fellows Meeting was held at the MIT Endicott House, November 1-3, 2013, with 54 current Fellows in attendance as well as the Scientific Advisory Committee, members of the Board of Trustees, and the Administrative Director. There were 20 presentations by the Fellows in their final year of fellowship support. Dan R. Littman, M.D., Ph.D, Professor of Molecular Immunology at , presented the Maclyn McCarty lecture.

The Foundation continues to think that the annual meeting is an important component of the fellowship program because of the opportunity it provides our Fellows for scientific interchange and exposure to biomedical fields other than their own.

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The Helen Hay Whitney Foundation Final - Year Fellows Fifty-Fifth Annual Fellows Meeting - November 2-4, 2012

Top row, left to right: Frank J. Poelwijk, Steven W. Flavell, Maulik R. Patel, Suzanne R. Lee, Iris H. Jonkers, Andy J. Chang, Gregory W. Schwartz, Jessica L. Feldman, Michael A. Crickmore.

Front row, left to right: Eugene A. Gladyshev, Shawn R. Olsen, Elizabeth J. Hong, Elena M. Gallo, Julia L. Semmelhack, Adam T. Boutin, Molly O. OhAinle, Yu (Julie) Chen, Paul A. Sigala.

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The Helen Hay Whitney Foundation Final - Year Fellows Fifty-Sixth Annual Fellows Meeting - November 1-3, 2013

Top row, left to right: Eiman Azim, Evan H. Feinberg, Walter M. Fischler, Joshua J. Bayes, Luis C. Fuentealba, Jerrod J. Schwartz, Dengke K. Ma, -Wei Li, Stephen G. Brohawn, Colin D. Malone, Jeffrey R. Moffitt.

Front row, left to right: Michael B. Manookin, Diana C. Hargreaves, Eric L. Greer, Yasemin S. Sancak, Xin Ye, Lillian K. Fritz-Laylin, Karen E. Kasza, Xin Zhang.

Absent from photo: Jeremiah Y. Cohen

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LOCATION OF FELLOWS COMPLETING FELLOWSHIP TENURE

Those who completed their fellowships during calendar year 2012, are listed below, together with their post-fellowship locations.

Adam T. Boutin, Ph.D. Instructor at MD Anderson Cancer Center.

Onn Brandman, Ph.D. Assistant Professor, Department of Biochemistry, .

Huaqing Cai, Ph.D. Research Associate, Devreotes Lab, .

Andy J. Chang, Ph.D. Postdoctoral Fellow, Krasnow Lab, Department of Biochemistry, Stanford University School of Medicine.

Sean R. Collins, Ph.D. Assistant Professor, Department of Microbiology and Molecular Genetics, University of California, Davis.

Michael A. Crickmore, Ph.D. Assistant Professor of Neurology, Boston Children's Hospital, Harvard University.

Felice A. Dunn, Ph.D. Assistant Professor, Department of Ophthalmology, University of California, San Francisco.

Ethan C. Garner, Ph.D. Assistant Professor, Molecular and Cellular Biology, Center for Systems Biology, Harvard University.

Lindsey L. Glickfeld, Ph.D. Assistant Professor, Department of Neurobiology, Duke University.

Adam L. Hughes, Ph.D. Principal Investigator, Department of Biochemistry, University of Utah.

Seppe Kuehn, Ph.D. Research Assistant Professor, Department of Physics, University of Illinois at Urbana-Champaign.

Comert Kural, Ph.D. Assistant Professor, Department of Physics, Department of Molecular & Cellular Biochemistry, Ohio State University.

Suzanne R. Lee, Ph.D. Assistant Professor of Biology, Western Washington University.

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Anselm C. Levskaya, Ph.D. Chief Scientist, Cambrian Genomics.

Diana E. Libuda, Ph.D. Principal Investigator, Assistant Professor of Biology, Department of Biology, Institute of Molecular Biology, University of Oregon.

Mirjam Mayer, Ph.D. Strategy Consultant, McKinsey & Company, Berlin, Germany.

Amy J. McMahon, Ph.D. Patent Agent, Biotechnology, Wolf Greenfield, Boston, MA.

Jayakrishnan Nandakumar, Ph.D. Assistant Professor, Department of Molecular, Cellular and Developmental Biology, University of Michigan Ann Arbor.

Molly O. OhAinle, Ph.D. Staff Scientist, Emerman Lab, Fred Hutchinson Cancer Research Center.

Gabriel M. Simon, Ph.D. Senior Scientist, Abide Therapeutics, San Diego, CA.

Marcos M. Sotomayor, Ph.D. Assistant Professor, Department of Chemistry and Biochemistry, The Ohio State University.

Casimir M. Wierzynski, Ph.D. Senior Staff Engineer, Qualcomm Research.

Ilana B. Witten, Ph.D. Assistant Professor, Psychology Department, Princeton University.

Caroline H. Yi, Ph.D.

Peng Yi, Ph.D. Assistant Investigator, Islet Cell and Regenerative Biology Section, Joslin Diabetes Center, Harvard Medical School.

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LOCATION OF FELLOWS COMPLETING FELLOWSHIP TENURE

Those who completed their fellowships during calendar year 2013, are listed below, together with their post-fellowship locations.

Yu (Julie) Chen, Ph.D. Postdoctoral Fellow, Rapoport lab, Harvard Medical School.

Jeremiah Y. Cohen, Ph.D. Assistant Professor of Neuroscience, The Johns Hopkins University.

Jessica L. Feldman, Ph.D. Assistant Professor, Biology, Stanford School of Medicine.

Steven W. Flavell, Ph.D. Postdoctoral Fellow, Bargmann Lab, The .

Luis C. Fuentealba, Ph.D. Scientist I, Neurona Therapeutics, CA.

Elena M. Gallo MacFarlane, Ph.D. Instructor, Dietz Lab, Johns Hopkins University.

Eugene A. Gladyshev, Ph.D. Postdoctoral Fellow, Kleckner Lab, Harvard University.

Eric L. Greer, Ph.D. Principal Investigator, Division of Newborn Medicine, Boston Children’s Hospital.

Diana C. Hargreaves, Ph.D. Assistant Professor, Cancer Research Center, Salk Institute for Biological Studies.

Elizabeth J. Hong, Ph.D. Research Fellow, Wilson Lab, Harvard Medical School.

Iris H. Jonkers, Ph.D. Senior Postdoctoral Research Fellow, Wijmenga Group, Genetics Department, University Medical Center Groningen, Netherlands.

Madeline A. Lancaster, Ph.D. Postdoctoral Fellow, Knoblich Lab, Institute of Molecular Biotechnology, Vienna, Austria.

Gene-Wei Li, Ph.D. Assistant Professor of Biology, Massachusetts Institute of Technology.

Dengke K. Ma, Ph.D. Assistant Professor, Cardiovascular Research Institute and Department of Physiology, University of California, San Francisco, School of Medicine.

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Juan L. Mendoza, Ph.D. Postdoctoral Research fellow, Molecular and Cellular Physiology, Stanford School of Medicine.

Jeffrey R. Moffitt, Ph.D. Postdoctoral Fellow, Zhuang Lab, Harvard University.

Shawn R. Olsen, Ph.D. Assistant Investigator, Neural Coding Group, Allen Institute for Brain Science.

Maulik R. Patel, Ph.D. Assistant Professor, Department of Biological Sciences, Vanderbilt University.

Frank J. Poelwijk, Ph.D. Postdoctoral Fellow, Ranganathan Lab, University of Texas Southwestern Medical Center.

Gregory W. Schwartz, Ph.D. Assistant Professor, Departments of Ophthalmology and Physiology, Northwestern University, Feinberg School of Medicine.

Jerrod J. Schwartz, Ph.D. Hardware Engineer, Google[x], Mountain View, CA.

Julia L. Semmelhack, Ph.D. Postdoctoral Fellow, Dept. Herwig Baier, Max Planck Institute of Neurobiology.

Paul A. Sigala, Ph.D. Postdoctoral Fellow, Goldberg Lab, Washington University, St. Louis.

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LIST OF AWARDS FOR 2012

Of the 520 applications received in 2012, 512 (99%) were from candidates with the Ph.D. or comparable degree awarded or pending, 7 from candidates with the M.D./Ph.D. degree, and 0 were from candidates with the M.D. degree. Of these applicants, 37 qualified for personal interview, and 21 were awarded fellowships.

Cristian Boboila, Ph.D. For training at Columbia University with Dr. Richard Axel. Imparting behavioral specificity on cortical representations.

Lauren N. Booth, Ph.D. For training at Stanford University with Dr. Anne Brunet. The Diversification and Evolution of Longevity.

Margaret F. Carr, Ph.D. For training at Stanford University with Dr. Mark Schnitzer. Dynamics of hippocampal ensemble representations during the formation of long-term memories.

Teresa Davoli, Ph.D. For training at Harvard Medical School with Dr. Stephen Elledge. Genetic screening to identify vulnerabilities associated with cancer-related PI3K mutations.

Michel J. DuPage, Ph.D. For training at the University of California, San Francisco with Dr. Jeffrey Bluestone. Temporal dissection of Ezh2 activity in regulatory T cell plasticity and function.

Margaret S. Ebert, Ph.D. For training at The Rockefeller University with Dr. Cori Bargmann. Peptide Neuromodulators and the Evolution of Behavior.

Stephen N. Floor, Ph.D. For training at the University of California, Berkeley with Dr. . Global analysis of the effect of 5 UTR regulatory elements on mammalian translation initiation.

Louise R. Giam, Ph.D. For training at Stanford University with Dr. Thomas Sudhof. Systematic High-throughput Screen to Understand the Roles of Transmembrane Protein Families in Neurons and to Quantify their Effects on Calcium Signaling Events.

Saher Sue Hammoud, Ph.D. For training at the University of Utah with Dr. David Jones. The role of retinoic acid in intestinal cell fating.

Zachary B. Hill, Ph.D. For training at the University of California, San Francisco with Dr. James Wells. Affinity-directed post-translational modification for identifying the protein targets of small-molecule drugs.

Weizhe Hong, Ph.D. For training at the California Institute of Technology with Dr. David Anderson. Functional Mapping of Neural Circuits Underlying Aggressive Behaviors.

Michael B. Lazarus, Ph.D. For training at the University of California, San Francisco with Dr. Kevan Shokat. Chemical tools to investigate alpha kinases.

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Anna B. Loveland, Ph.D. For training at with Dr. Nikolaus Grigorieff and Dr. Melissa J. Moore. Single-particle electron cryo-microscopy reconstruction of pre- and post-second step spliceosomes.

Juan L. Mendoza, Ph.D. For training at Stanford University with Dr. K. Christopher Garcia. Diversifying interferon functions through combinatorial and structural biology.

Joseph Andrew Miri, Ph.D. For training at Columbia University with Dr. Tom Jessell. The microcircuitry of motor cortical firing dynamics.

Amy Pandya-Jones, Ph.D. For training at the University of California, Los Angeles with Dr. Kathrin Plath. Mechanisms of epigenetic silencing of the X chromosome.

Anupam Patgiri, Ph.D. For training at The Rockefeller University with Dr. Tarun Kapoor. A Chemical Genetic Approach to Unravel Mechanisms of Ribosome Biogenesis.

Elena Piskounova, Ph.D. For training at the University of Texas, Southwestern with Dr. Sean Morrison. Role of Lyn Kinase signalling cascade in melanoma metastasis.

Vidhya Ramachandran, Ph.D. For training at the University of California, Berkeley with Dr. Andrew Dillin. Role of neuronal signaling in cell non-autonomous unfolded protein response.

Omri Wurtzel, Ph.D. For training at the Whitehead Institute with Dr. Peter Reddien. Unbiased discovery of regulators of planarian regeneration by massive RNAi screening.

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LIST OF AWARDS FOR 2013

Of the 531 applications received in 2013, 515 (97%) were from candidates with the Ph.D. or comparable degree awarded or pending, 11 from candidates with the M.D./Ph.D. degree, and 3 were from candidates with the M.D. degree. Of these applicants, 39 qualified for personal interview, and 25 were awarded fellowships.

Vinayak Agarwal, Ph.D. For training at the University of California, San Diego with Dr. Bradley S Moore. If halogens could kill - understanding bacterial synthesis of polyhalogenated human toxins.

Daniele Canzio, Ph.D. For training at Columbia University with Dr. Tom Maniatis. Mechanisms of Protocadherin pre-mRNA Splicing in the Mammalian Brain.

Mark P. Chao, M.D., Ph.D. For training at the Stanford University with Dr. Joseph Wu. Generation of induced pluripotent stem cells from myeloproliferative neoplasms for disease modeling and drug discovery.

Eleanor J. Clowney, Ph.D. For training at the Rockefeller University with Dr. Vanessa Ruta. Evolution of a neural circuit in Drosophila.

Christine M. Constantinople, Ph.D. For training at Princeton University with Dr. David Tank Carlos Brody. Imaging neural dynamics during working memory in behaving rats.

Steven DeLuca, Ph.D. For training at the Carnegie Institute of Washington with Dr. Allan Spradling. How does an organism defend itself from an invasion by a new transposable element?

Wulan Deng, Ph.D. For training at the Janelia Farm Research Campus, HHMI with Dr. Robert Singer. Direct Imaging of long-range enhancer-promoter interactions and transcription in live mammalian cells.

Yejin Eun, Ph.D. For training at Harvard University with Dr. Ethan Garner. Building a mechanistic model for regulation of cell wall growth rate in bacteria.

Christopher B. Ford, Ph.D. For training at the Broad Institute with Dr. Aviv Regev. Quantitative analysis of the evolution of C. albicans host-pathogen interactions.

Naomi Habib, Ph.D. For training at the Broad Institute with Dr. Feng Zhang. Elucidating the cell-type specific transcription of coding and non-coding RNAs following neural activity and learning, by single-nuclei RNA-seq.

Elliott J. Hagedorn, Ph.D. For training at Children's Hospital, Boston with Dr. Leonard Zon. Intercellular Communication that Guides Homing and Niche Engraftment of Hematopoietic Stem Cells.

Nicholas T. Hertz, Ph.D. For training at the Rockefeller University with Dr. Marc Tessier-Lavigne. Identification and characterization of caspase substrates that regulate axon degeneration in development and disease.

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Lishi Li, Ph.D. For training at the Rockefeller University with Dr. Elaine Fuchs. Exploring Crosstalk Between Skin Stem Cells and the Sensory Nervous System.

Tania J. Lupoli, Ph.D. For training at Weill Cornell Medical College, NY with Dr. Carl Nathan. Determining the molecular players involved in asymmetric division as a mechanism of oxidative stress resistance in Mycobacterium tuberculosis.

Nicholas A. Lyons, Ph.D. For training at Harvard Medical School with Dr. Roberto Kolter. Molecular Basis of Kin Discrimination in Bacillus subtilis.

Priyanka Narayan, Ph.D. For training at the Whitehead Institute with Dr. Susan Lindquist. Profiling the interactome of clusterin in neurodegeneration and cancer.

Candice E. Paulsen, Ph.D. For training at the University of California, San Francisco with Dr. . Uncovering the mechanism of TRPA1 activation by agonists.

Ho Sung Rhee, Ph.D. For training at Columbia University with Dr. Hynek Wichterle. ChIP-print: Genome-wide Mapping of Transcription Factor Interactions during Stem Cell to Motor Neuron Programming.

Jeremy M. Rock, Ph.D. For training at Harvard School of Public Health with Dr. Sarah Fortune Eric Rubin. The evolution of drug resistance in M. tuberculosis.

David M. Schneider, Ph.D. For training at Duke University with Dr. Richard Mooney. Neural circuit mechanisms for predicting the acoustic consequences of movement.

Nilesh Vaidya, Ph.D. For training at Princeton University with Dr. Cliff Brangwynne. FG/RGG mediated nucleolar assembly and its impact on the growth dynamics of C. elegans.

Amy M. Weeks, Ph.D. For training at the University of California, San Francisco with Dr. James Wells. Identification of membrane protein interaction partners via proximity- based enzymatic tagging.

Xin Xiong, Ph.D. For training at the University of California, San Francisco with Dr. Wendell Lim. Optogenetic manipulation of neuronal morphology: synthetic biology interrogation of neuronal morphogenesis and regeneration.

Shu Zhu, Ph.D. For training at with Dr. Richard Flavell. The functions of long noncoding RNAs in T helper 17 cell mediated autoimmunity.

Elizabeth Zuniga-Sanchez, Ph.D. For training at the University of California, Los Angeles with Dr. Stephen L. Zipursky. Synaptic Determinants of the Vertebrate Retina.

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SCIENTIFIC PUBLICATIONS

The following publications based on research aided by Foundation support have appeared in the medical literature by those who completed their fellowships through December 31, 2013. Included in this listing may be articles received too late to be included in the previous report. An asterisk identifies the author supported by the Foundation.

*Andermann Mark L, Kerlin AM, Roumis DK, *Glickfeld Lindsey L, Reid RC (2011) Functional specialization of mouse higher visual cortical areas.Neuron, 72: 1025-39.

*Bloodgood L. Brenda, Sharma N, Browne HA, Trepman AZ, Greenberg ME. The activity- dependent transcription factor NPAS4 regulates domain-specific inhibition. Nature. 2013 Nov 7;503(7474):121-5. doi: 10.1038/nature12743.

Kaneko S, Son J, Shen SS, Reinberg D, *Bonasio Roberto. PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells. Nat Struct Mol Biol. 2013 Nov;20(11):1258-64. doi: 10.1038/nsmb.2700. Epub 2013 Oct 20.

Andrew S Cowburn, Norihiko Takeda, *Adam T Boutin, Jung-Whan Kim, Jane C Sterling, Manando Nakasaki, Mark Southwood, Ananda W Goldrath, Colin Jamora, Victor Nizet, Edwin R Chilvers, Randall S Johnson. HIF isoforms in the skin differentially regulate systemic arterial pressure. PNAS vol. 110 no. 43, 17570–17575, doi: 10.1073/pnas.1306942110.

Jian Hu, Soyoon Sarah Hwang, Marc Liesa, Boyi Gan, Ergun Sahin, Mariela Jaskelioff, Zhihu Ding, Haoqiang Ying, *Adam T. Boutin, Hailei Zhang, Shawn Johnson, Elena Ivanova, Maria Kost-Alimova, Alexei Protopopov, Yaoqi Alan Wang, Orian S. Shirihai, Lynda Chin, Ronald A. DePinho. Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer. Cell Volume 148, Issue 4, p651–663, 17 February 2012.

Frost A, Elgort MG, *Brandman Onn, Ives C, Collins SR, Miller-Vedam L, Weibezahn J, Hein MY, Poser I, Mann M, Hyman AA, Weissman JS. Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions. Cell. 2012 Jun 8;149(6):1339-52. doi: 10.1016/j.cell.2012.04.028.

*Brandman Onn, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, Zhou S, King D, Shen PS, Weibezahn J, Dunn JG, Rouskin S, Inada T, Frost A, Weissman JS. A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Cell. 2012 Nov 21;151(5):1042-54. doi: 10.1016/j.cell.2012.10.044.

Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, *Brandman Onn, Whitehead EH, Doudna JA, Lim WA, Weissman JS, Qi LS. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell. 2013 Jul 18;154(2):442-51. doi: 10.1016/j.cell.2013.06.044. Epub 2013 Jul 11.

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*Cai Huaqing, Katoh-Kurasawa M, Muramoto T, Santhanam B, Long Y, Li L, Ueda M, Iglesias PA, Shaulsky G, and Devreotes PN. Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer. Science. 2014 Mar 21;343(6177):1249531. doi: 10.1126/science.1249531.

*Cai Huaqing, Huang, C.H., Devreotes, P.N., and Iijima, M. 2012 Analysis of chemotaxis in Dictyostelium. Methods Mol Biol 757:451-468.

*Cai Huaqing, and Devreotes, P.N. 2011 Moving in the right direction: How eukaryotic cells migrate along chemical gradients. Semin. Cell Dev. Biol. 22:834-841.

Kamimura, Y., *Cai Huaqing, Tang, M., and Devreotes, P.N. 2010 TorC2 and chemotaxis in Dictyostelium discoideum. In: The Enzymes (Michael N. Hall and Fuyuhiko Tamanoi, eds.). Acadmic Press, Volume 28, pp. 125-142.

*Cai Huaqing, Das, S., Kamimura, Y., Comer, F.I., Parent, D.A., and Devreotes, P.N. 2010 Ras-mediated activation and inactivation of the TorC2-PKB pathway are critical for chemotaxis. J. Cell Biol., 190:233-245. PMCID: PMC2930282.

Benedikt W. Bauer, Tom Shemesh, *Yu Chen, Tom A. Rapoport. A “Push and Slide” Mechanism Allows Sequence-Insensitive Translocation of Secretory by the SecA ATPase. Cell. Volume 157, Issue 6, 5 June 2014, Pages 1416–1429.

*Cohen, Jeremiah Y., M.W. Amoroso & N. Uchida (2015) Serotonergic neurons signal reward and punishment on multiple timescales. eLife 4: e06346.

Ogawa, S.K., *Jeremiah Y Cohen, D. Hwang, N. Uchida & M. Watabe-Uchida (2014) Organization of monosynaptic inputs to the serotonin and dopamine neuromodulatory systems. Cell Reports 8: 1105-1118.

*Cohen, Jeremiah Y., S. Haesler, L. Vong, B.B. Lowell & N. Uchida (2012) Neuron-type- specific signals for reward and punishment in the ventral tegmental area. Nature 482: 85-88.

*Collins Sean R, Meyer T. 2011. Evolutionary origins of STIM1 and STIM2 within ancient Ca2+ signaling systems. Trends Cell Biol 21(4):202-11.

*Collins Sean, Meyer T. 2010. Cell biology: A sensor for calcium uptake. Nature 467(7313):283.

*Crickmore Michael A, Vosshall LB. Opposing dopaminergic and GABAergic neurons control the duration and persistence of copulation in Drosophila. Cell. 2013 Nov 7;155(4):881-93. doi: 10.1016/j.cell.2013.09.055.

*Ding Lei, Morrison SJ. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature. 2013 Mar 14;495(7440):231-5. doi: 10.1038/nature11885. Epub 2013 Feb 24.

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*Feldman, Jessica L., Priess, J.R. A Role for the Centrosome and PAR-3 in the Hand-Off of MTOC Function during Epithelial Polarization CURRENT BIOLOGY. 2012; 22 (7): 575-582.

Dennis, S., Sheth, U., *Feldman, Jessica L., English, K. A., and Priess, J. R. (2012) C. elegans Germ Cells Show Temperature and Age-Dependent Expression of Cer1, a Gypsy/Ty3-Related Retrotransposon. PLoS Pathog 8, e1002591.

Rasmussen JP, *Feldman, Jessica L, Reddy SS, Priess JR. (2013) Cell Interactions and Patterned Intercalations Shape and Link Epithelial Tubes in C. elegans. PLoS Genet. Sep;9(9):e1003772.

*Dunn Felice A, Wong RO. Wiring patterns in the mouse retina: collecting evidence across the connectome, physiology and light microscopy. J Physiol. 2014 Nov 15; 592(Pt 22):4809-23.

*Dunn Felice A, Della Santina L, Parker ED, Wong RO. Sensory experience shapes the development of the visual system's first synapse. Neuron. 2013 Dec 4; 80(5):1159-66.

*Flavell Steven W, Pokala N, Macosko EZ, Albrecht DR, Larsch J, Bargmann CI. Serotonin and the neuropeptide PDF initiate and extend opposing behavioral states in C. elegans. Cell. 2013 Aug 29;154(5):1023-35.

Merkle FT, *Fuentealba Luis C, Sanders TA, Magno L, Kessaris N, Alvarez-Buylla A. Adult neural stem cells in distinct microdomains generate previously unknown interneuron types. Nature neuroscience [Internet]. 2014 Feb [cited 2014 Feb 3];17(2):207–14.

Tan FE, Vladar EK, Ma L, *Fuentealba Luis C, Hoh R, Espinoza FH, Axelrod JD, Alvarez- Buylla A, Stearns T, Kintner C, Krasnow MA. Myb promotes centriole amplification and later steps of the multiciliogenesis program. Development (Cambridge, England) [Internet]. 2013 Oct [cited 2014 Feb 2];140(20):4277–86.

*Fuentealba Luis C, Obernier K, Alvarez-Buylla A. Adult neural stem cells bridge their niche. Cell stem cell [Internet]. 2012 Jun 14 [cited 2014 Feb 1];10(6):698–708.

Tsai H-H, Li H, *Fuentealba Luis C, Molofsky A V, Taveira-Marques R, Zhuang H, Tenney A, Murnen AT, Fancy SPJ, Merkle FT, Kessaris N, Alvarez-Buylla A, Richardson WD, Rowitch DH. Regional astrocyte allocation regulates CNS synaptogenesis and repair. Science (New York, NY) [Internet]. 2012 Jul 20 [cited 2014 Feb 1];337(6092):358–62.

Elizabeth E. Gerber, *Elena M. Gallo, Stefani C. Fontana, Elaine C. Davis, Fredrick M. Wigley, David L. Huso & Harry C. Dietz. Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma. Nature 503, 126–130 (07 November 2013).

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*Elena M. Gallo, David C. Loch, Jennifer P. Habashi, Juan F. Calderon, Yichun Chen, Djahida Bedja, Christel van Erp, Elizabeth E. Gerber, Sarah J. Parker, Kimberly Sauls, Daniel P. Judge, Sara K. Cooke, Mark E. Lindsay, Rosanne Rouf, Loretha Myers, Colette M. ap Rhys, Kathleen C. Kent, Russell A. Norris, David L. Huso, and Harry C. Dietz1. Angiotensin II–dependent TGF- β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis. J Clin Invest. 2014 Jan 2; 124(1): 448–460.

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FINANCIAL STATEMENTS THE HELEN HAY WHITNEY FOUNDATION Grants and Fellowships Paid

1947 $56,130 1980-1981 $778,602 1948 $90,329 1981-1982 $879,009 1949 $161,252 1982-1983 $916,871 1950 $225,747 1983-1984 $939,950 1951 $248,357 1984-1985 $971,522 1952 $250,592 1985-1986 $1,008,528 1953 $235,463 1986-1987 $1,013,578 1954 $215,550 1987-1988 $1,071,616 1955 $207,385 1988-1989 $1,189,620 1956 $189,322 1989-1990 $1,304,464 1957 (to June 30) $74,291 1990-1991 $1,257,586 1957-1958 $190,618 1991-1992 $1,347,051 1958-1959 $327,051 1992-1993 $1,179,053 1959-1960 $302,799 1993-1994 $1,437,364 1960-1961 $313,058 1994-1995 $1,478,573 1961-1962 $345,616 1995-1996 $1,430,955 1962-1963 $366,869 1996-1997 $1,514,142 1963-1964 $411,466 1997-1998 $1,632,663 1964-1965 $450,260 1998-1999 $1,840,414 1965-1966 $455,036 1999-2000 $1,929,966 1966-1967 $490,070 2000-2001 $1,755,148 1967-1968 $498,850 2001-2002 $2,688,021 1968-1969 $542,033 2002-2003 $2,824,955 1969-1970 $526,698 2003-2004 $2,750,190 1970-1971 $700,202 2004-2005 $2,486,105 1971-1972 $618,935 2005-2006 $2,190,768 1972-1973 $579,649 2006-2007 $2,364,533 1973-1974 $566,145 2007 (to Dec 31) $777,292 1974-1975 $552,629 2008 $2,488,613 1975-1976 $578,233 2009 $2,474,765 1976-1977 $579,417 2010 $2,610,683 1977-1978 $663,775 2011 $2,949,942 1978-1979 $606,831 2012 $2,880,533 1979-1980 $810,571 2013 $2,874,901

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The Helen Hay Whitney Foundation Statement of Financial Position December 31, 2012

ASSETS Current Assets Cash and cash equivalents $ 628,893 Interest and dividends receivable 125,549 Due from broker 29,176 Prepaid excise taxes 16,322 Prepaid expenses 2,560 Total current assets 802,500

Investments at fair value 51,162,784 Furniture and equipment, net of accumulated depreciation of $24,826 3,063 Deposits 1,457 Total assets $ 51,969,804

LIABILITIES AND UNRESTRICTED NET ASSETS Liabilities Current Liabilities Grants and fellowships payable $ 563,125 Due to broker 1,541 Other payables 43,051 Excise taxes and filing fees payable 1,775 Total current liabilities 609,492

Deferred excise taxes payable 115,565 Total liabilities 725,057

Unrestricted net assets 51,244,747 Total liabilities and unrestricted net assets $ 51,969,804

COMPLETE AUDITED FINANCIAL STATEMENTS OF THE HELEN HAY WHITNEY FOUNDATION ARE AVAILABLE FOR INSPECTION AT THE FOUNDATION'S OFFICE AT 20 SQUADRON BLVD, SUITE 630, NEW CITY, NY 10956

Page 25 of 29 The Helen Hay Whitney Foundation Statement of Activities Year Ended December 31, 2012

Revenue Contributions $ 1,724,690 Interest 411,131 Dividends 505,068 Partnership income 1,007,772 Total revenue 3,648,661

Expenses Fellowships and grants 2,880,533 Program expenses 285,622 Fund raising expenses 5,674 General and administrative 421,796 Provision for taxes and fees 66,558 Total expenses 3,660,183

Decrease in net assets before net realized and unrealized gains on investments (11,522)

Realized and unrealized gains on investments Net realized gains on investments 987,403 Net unrealized gains on investments 1,925,788 2,913,191

Increase in net assets 2,901,669 Unrestricted net assets, beginning of year 48,343,078 Unrestricted net assets, end of year $ 51,244,747

COMPLETE AUDITED FINANCIAL STATEMENTS OF THE HELEN HAY WHITNEY FOUNDATION ARE AVAILABLE FOR INSPECTION AT THE FOUNDATION'S OFFICE AT 20 SQUADRON BLVD, SUITE 630, NEW CITY, NY 10956

Page 26 of 29 The Helen Hay Whitney Foundation Statement of Financial Position December 31, 2013

ASSETS Current Assets Cash and cash equivalents $ 1,161,966 Interest and dividends receivable 109,147 Due from broker 2 Prepaid excise taxes - Prepaid expenses 2,560 Total current assets 1,273,675

Investments at fair value 60,516,458 Furniture and equipment, net of accumulated depreciation of $23,308 3,682 Deposits 1,457 Total assets $ 61,795,272

LIABILITIES AND UNRESTRICTED NET ASSETS Liabilities Current Liabilities Grants and fellowships payable $ 703,875 Due to broker 22,794 Other payables 43,205 Excise taxes and filing fees payable 104,824 Total current liabilities 874,698

Deferred excise taxes payable 201,485 Total liabilities 1,076,183

Unrestricted net assets 60,719,089 Total liabilities and unrestricted net assets $ 61,795,272

COMPLETE AUDITED FINANCIAL STATEMENTS OF THE HELEN HAY WHITNEY FOUNDATION ARE AVAILABLE FOR INSPECTION AT THE FOUNDATION'S OFFICE AT 20 SQUADRON BLVD, SUITE 630, NEW CITY, NY 10956

Page 27 of 29 The Helen Hay Whitney Foundation Statement of Activities Year Ended December 31, 2013

Revenue Contributions $ 1,754,124 Interest 264,265 Dividends 619,280 Partnership income 978,037 Total revenue 3,615,706

Expenses Fellowships and grants 2,874,901 Program expenses 289,493 Fund raising expenses 5,678 General and administrative 432,038 Provision for taxes and fees 226,436 Total expenses 3,828,546

Decrease in net assets before net realized and net unrealized gains on investments (212,840)

Realized and unrealized gains on investments Net realized gains on investments 4,037,499 Net unrealized gains on investments 5,649,683 9,687,182

Increase in net assets 9,474,342 Unrestricted net assets, beginning of year 51,244,747 Unrestricted net assets, end of year $ 60,719,089

COMPLETE AUDITED FINANCIAL STATEMENTS OF THE HELEN HAY WHITNEY FOUNDATION ARE AVAILABLE FOR INSPECTION AT THE FOUNDATION'S OFFICE AT 20 SQUADRON BLVD, SUITE 630, NEW CITY, NY 10956

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TO ALL FORMER HELEN HAY WHITNEY FOUNDATION FELLOWS:

The Foundation maintains a former fellows' directory on our website at www.hhwf.org.

Please help us keep our former fellows' directory up-to-date.

Search your information at: http://hhwf.org/Dir/register.php You may update your information at: http://hhwf.org/Dir/search.php

Or via email: [email protected]

Thank you

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