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The Helen Hay Whitney Foundation Final - Year Fellows Fifty-Fifth Annual Fellows Meeting - November 2-4, 2012

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The Helen Hay Whitney Foundation Final - Year Fellows Fifty-Fifth Annual Fellows Meeting - November 2-4, 2012 THE HELEN HAY WHITNEY FOUNDATION 2012-2013 Annual REport 20 Squadron Boulevard, Suite 630 New City, NY 10956 www.hhwf.org Tel: (845) 639-6799 Fax: (845) 639-6798 THE HELEN HAY WHITNEY FOUNDATION BOARD OF TRUSTEES Averil Payson Meyer, President Steven C. Harrison, Ph.D., Vice President Lisa A. Steiner, M.D., Vice President W. Perry Welch, Treasurer Thomas M. Jessell, Ph.D. Payne W. Middleton Thomas P. Sakmar, M.D. Stephen C. Sherrill Jerome Gross, M.D., Trustee Emeritus SCIENTIFIC ADVISORY COMMITTEE Steven C. Harrison, Ph.D., Chairman David J. Anderson, Ph.D. Daniel Kahne, Ph.D. Philippa Marrack, Ph.D. Markus Meister, Ph.D. Barbara J. Meyer, Ph.D. Matthew D. Scharff, M.D. Julie A. Theriot, Ph.D. Jonathan S. Weissman, Ph.D. S. Lawrence Zipursky, Ph.D. ADMINISTRATIVE DIRECTOR and SECRETARY Robert Weinberger Page 1 of 29 REPORT OF THE VICE PRESIDENT AND CHAIRMAN, SCIENTIFIC ADVISORY COMMITTEE The past two years have been eventful ones. The generosity of the Simons Foundation has allowed us to increase by three the number of fellows we select each year, giving us a class of about 24. Tom Jessell, a former SAC member and now a Trustee, was instrumental in helping us approach the Simons Foundation, which has an extremely interesting overall plan for support of frontier biomedical research and with which I can foresee more extensive interactions going forward. We also increased by one the number of SAC members, to enhance coverage in fields such as systems neuroscience and mathematical modeling, in which we have received applications that have challenged the expertise of the eight-member group. I was delighted when everyone's first choice, Markus Meister, Professor of Biology at Caltech, accepted our invitation with little hesitation. Markus studies neuronal circuits, with the goal of identifying the computation performed by a particular circuit (e.g., in the olfactory bulb or the retina), working out the mechanism behind this computation, and explaining how this circuit fits into the larger context of a brain. Shortly after Markus came on board, Erin O'Shea stepped down from the SAC when she accepted the position of Chief Scientific Officer at the Howard Hughes Medical Institute. Erin's experience and expertise in fields that range from structural biology and biochemistry to systems biology and cell biology have brought wisdom to our discussions, and her focused and no-nonsense view of evaluations and decisions will be huge assets in her responsibilities at HHMI, as they have been for us. Jonathan Weissman, Professor of Cellular and Molecular Pharmacology at UCSF, who agreed to join the SAC in time for the 2013 selection cycle, is the ideal person to bring comparable breadth and wisdom. Jonathan has devised powerful and elegant tools to probe the systems biology of a cell by exploiting his deep insights about molecular mechanism, based in part on his discoveries in such fields as protein folding and prion biology. Matthew Scharff, the longest standing member of the SAC, decided to step down at the end of the 2013 selection cycle. Matty, a distinguished immunologist, has brought perspective to our deliberations in an area of great traditional strength among Helen Hay Whitney Fellows. Fortunately, another very distinguished immunologist, Philippa Marrack, of National Jewish Health in Denver, well known for her work on T-cell development and on identifying the T- cell receptor, is our most recently appointed member. I have admired Pippa's approach to scientific questions and scientific judgments for many years, and I look forward to more regular encounters. The Annual Meeting continues to be a high point of Foundation activities. Participation in these meetings allows Fellows working at different institutions to get to know each other and builds a sense of community that lasts well beyond the three years of their appointment. Robert Weinberger organizes that meeting, and indeed all of our efforts, with remarkable effectiveness and attention to detail. Almost without exception, the acknowledgment slides in the presentations from third-year Fellows at the Annual Meeting include a generous and well deserved recognition of Robert's contribution. In their statements of gratitude, they also speak for the SAC. Stephen C. Harrison, Ph.D. Page 2 of 29 ORGANIZATION The Foundation was established and endowed by Mrs. Charles S. Payson, the former Joan Whitney, in 1947, and named in honor of her mother, Helen Hay Whitney. The current Postdoctoral Research Fellowship Program was begun in 1956. The Foundation is a New York State not-for-profit corporation. The corporation elects a Board of Trustees of not more than eleven members at its annual meeting. Full power in the management and control of the affairs of the corporation is vested in this Board, which holds two stated meetings a year. An Executive Committee acts for the Board in the intervals between meetings. The Postdoctoral Research Fellowship Program is the responsibility of the Scientific Advisory Committee and is under its continual review and evaluation. The day-to-day administration of the fellowship program is the responsibility of the Administrative Director, who reports to the Chairman of the Scientific Advisory Committee. PURPOSE The Foundation was established to stimulate and support research in the area of rheumatic fever and rheumatic heart disease, later expanding its interests to include diseases of connective tissue and, ultimately, all basic biomedical sciences. Under the Foundation’s program, young men and women planning careers in biological or medical research receive financial support of sufficient duration to help further their professional careers. Residents of the United States, Canada, and Mexico who hold the M.D., Ph.D., or equivalent degree, or US citizens residing abroad, are eligible to apply for a fellowship for beginning postdoctoral training in biomedical research. Page 3 of 29 THE WALTER BAUER MEMORIAL MEETING The Annual meeting of Fellows is held in November each year, and at this meeting each third-year Fellow speaks on the results of his or her research during the tenure of the fellowship. The Foundation also invites a distinguished scientist to present the Maclyn McCarty Annual Lecture. The Fifty-Fifth Annual Fellows Meeting was held at the MIT Endicott House, November 2-4, 2012, with 56 current Fellows in attendance as well as the Scientific Advisory Committee, members of the Board of Trustees, and the Administrative Director. There were 18 presentations by the Fellows in their final year of fellowship support. Jack W. Szostak, Ph.D., Professor of Genetics at Harvard Medical School, Professor of Chemistry and Chemical Biology at Harvard University, and Alexander Rich Distinguished Investigator at Massachusetts General Hospital, presented the Maclyn McCarty lecture. The Fifty-Sixth Annual Fellows Meeting was held at the MIT Endicott House, November 1-3, 2013, with 54 current Fellows in attendance as well as the Scientific Advisory Committee, members of the Board of Trustees, and the Administrative Director. There were 20 presentations by the Fellows in their final year of fellowship support. Dan R. Littman, M.D., Ph.D, Professor of Molecular Immunology at New York University, presented the Maclyn McCarty lecture. The Foundation continues to think that the annual meeting is an important component of the fellowship program because of the opportunity it provides our Fellows for scientific interchange and exposure to biomedical fields other than their own. Page 4 of 29 The Helen Hay Whitney Foundation Final - Year Fellows Fifty-Fifth Annual Fellows Meeting - November 2-4, 2012 Top row, left to right: Frank J. Poelwijk, Steven W. Flavell, Maulik R. Patel, Suzanne R. Lee, Iris H. Jonkers, Andy J. Chang, Gregory W. Schwartz, Jessica L. Feldman, Michael A. Crickmore. Front row, left to right: Eugene A. Gladyshev, Shawn R. Olsen, Elizabeth J. Hong, Elena M. Gallo, Julia L. Semmelhack, Adam T. Boutin, Molly O. OhAinle, Yu (Julie) Chen, Paul A. Sigala. Page 5 of 29 The Helen Hay Whitney Foundation Final - Year Fellows Fifty-Sixth Annual Fellows Meeting - November 1-3, 2013 Top row, left to right: Eiman Azim, Evan H. Feinberg, Walter M. Fischler, Joshua J. Bayes, Luis C. Fuentealba, Jerrod J. Schwartz, Dengke K. Ma, Gene-Wei Li, Stephen G. Brohawn, Colin D. Malone, Jeffrey R. Moffitt. Front row, left to right: Michael B. Manookin, Diana C. Hargreaves, Eric L. Greer, Yasemin S. Sancak, Xin Ye, Lillian K. Fritz-Laylin, Karen E. Kasza, Xin Zhang. Absent from photo: Jeremiah Y. Cohen Page 6 of 29 LOCATION OF FELLOWS COMPLETING FELLOWSHIP TENURE Those who completed their fellowships during calendar year 2012, are listed below, together with their post-fellowship locations. Adam T. Boutin, Ph.D. Instructor at MD Anderson Cancer Center. Onn Brandman, Ph.D. Assistant Professor, Department of Biochemistry, Stanford University. Huaqing Cai, Ph.D. Research Associate, Devreotes Lab, Johns Hopkins University. Andy J. Chang, Ph.D. Postdoctoral Fellow, Krasnow Lab, Department of Biochemistry, Stanford University School of Medicine. Sean R. Collins, Ph.D. Assistant Professor, Department of Microbiology and Molecular Genetics, University of California, Davis. Michael A. Crickmore, Ph.D. Assistant Professor of Neurology, Boston Children's Hospital, Harvard University. Felice A. Dunn, Ph.D. Assistant Professor, Department of Ophthalmology, University of California, San Francisco. Ethan C. Garner, Ph.D. Assistant Professor, Molecular and Cellular Biology, Center for Systems Biology, Harvard University. Lindsey L. Glickfeld, Ph.D. Assistant Professor, Department of Neurobiology, Duke University. Adam L. Hughes, Ph.D. Principal Investigator, Department of Biochemistry, University of Utah. Seppe Kuehn, Ph.D. Research Assistant Professor, Department of Physics, University of Illinois at Urbana-Champaign. Comert Kural, Ph.D. Assistant Professor, Department of Physics, Department of Molecular & Cellular Biochemistry, Ohio State University. Suzanne R. Lee, Ph.D. Assistant Professor of Biology, Western Washington University. Page 7 of 29 Anselm C.
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