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The Institut Pasteur Community Human health at the heart of our mission 2018 Annual Report Institut Pasteur researchers strive year on year to advance science and improve human health Contents THE INSTITUT PASTEUR’S STAFF CURRENTLY INCLUDES: 02 Interview with Christian Vigouroux, Chairman of the Board of Directors NOBEL PRIZES INTERNATIONAL AWARDS 04 Interview with Stewart Cole, President 06 Review of the year 2018 14 Awards and appointments in 2018 16 RESEARCH 18 Cell Biology and Infection 20 Developmental and Stem Cell Biology 1 Gairdner Award recipient 22 Structural Biology and Chemistry 1 Nobel Laureate 1 Kavli Prize for Neuroscience recipient (10 laureates since 1907) 24 Genomes and Genetics 1 Sjöberg Prize from the Royal Swedish Academy recipient 26 Immunology 1 Balzan Prize recipient 28 Infection and Epidemiology CNRS MEDALS 1 Brain Prize recipient 30 Microbiology 3 Robert Koch Prize recipients 32 Mycology 3 L’Oréal-UNESCO For Women in Science Award 34 Neuroscience recipients 36 Parasites and Insect Vectors 4 Louis-Jeantet Prize recipients 38 Virology 40 Center for Global Health (CGH) 2 CNRS Gold Medal recipients 42 Department of Technology and Scientific Programs (DTPS) 6 CNRS Silver Medal recipients EUROPEAN GRANTS 45 Center for Bioinformatics, Biostatistics and Integrative Biology (C3BI) 6 CNRS Bronze Medal recipients 48 Academic partnerships within France OTHER FRENCH AWARDS 50 HEALTH 52 Center for Translational Science (CRT) EUROPEAN RESEARCH COUNCIL (ERC) GRANTS 54 National Reference Centers (CNRs) 23 ERC Starting Grant recipients 56 Medical Center (CMIP) 19 ERC Advanced Grant recipients ERC Consolidator Grant recipients 58 INNOVATION 8 Inserm Grand Prix for Medical Research ERC Proof of Concept Grant recipients 60 Research applications and technology transfer 3 2 recipients 5 Allianz/Institut de France Foundation 64 EDUCATION Research Prize recipients APPOINTMENTS 66 Transferring and sharing scientific knowledge 1 Emile Jungfleisch Grand Prix recipient 1 Inria Grand Prix recipient 70 COOPERATION 2 Cancer Research Awards from the Simone 72 International highlights of 2018 and Cino Del Duca Foundation-Institut de France recipients 76 SUPPORT 2 Mémain-Pelletier Award recipients 5 members of the US National Academy 78 Financial review of 2018 11 Schlumberger Foundation for Education of Sciences, Washington (USA) 80 Promoting sustainable development and Research Prize recipients 4 members of the British Royal Society 82 An HR team supporting the Institut Pasteur community 38 members of EMBO (European Molecular 84 Donations, sponsorship and legacies: your support humbles and inspires us Biology Organization) 88 Board of Directors 20 members of the French Academy 89 Scientific Council of Sciences 90 Governing bodies 91 Management of the Institut Pasteur 1 INTERVIEW WITH Human health is central to our work, as reiterated in the Strategic Plan. Yes – that is the path we have chosen. We have decided to focus on tackling diseases that represent a threat from a global health We adopted the new Strategic Plan both perspective. This is very much in line with current health approaches, as reflected for scientists – the fabric of our institute in the modernization of the French Act on the Prevention of Vector-Borne Diseases, such as diseases caused by the Aedes –, and for patients and populations – albopictus mosquito1. This is the Institut Pasteur’s objective as it looks to ” consolidate its CNRs, encourage the the reason we exist. involvement of its scientists in the development of research applications, and further its support for innovative translational projects in cooperation Christian Vigouroux with LabEx laboratories. Public health is a long-standing mission at the Chairman of the Board of Directors Institut Pasteur. and sponsors are favorable and may progress, such as collaborating in the well stay that way. I would like to creation of a Hearing Institute (Institut emphasize two of the plan’s objectives de l’Audition). What are your wishes for What were the highlights of 2018 We adopted the plan both for scientists that are guiding our work. the Institut Pasteur in 2019? – the fabric of our institute –, and for Our motto, “increasing the impact in human and scientific terms? patients and populations – the reason of research on health”, keeps us firmly Back in 2017, you pointed to the I would say that it is up to the Institut we exist. I would add that developing rooted in the Pasteurian approach. importance of biosafety and CNRs Pasteur to extend its wishes to all those 2018 was a year of consolidation and a Strategic Plan encourages And the objective of strengthening who recognize and appreciate it, who ambition. It also marked the Institut a forward-looking approach, our existing national and international in the Institut Pasteur’s approach. admire, support, help and finance its work. Pasteur’s 130th anniversary and saw and it brings people together. partnerships to boost the Institut The plan gives new momentum In any case, 2019 is off to a busy start for the opening of new facilities such as the It made us think about what we want Pasteur’s scientific excellence the Board of Directors, which will strive to Excellence means Titan KriosTM and the Omics buildings for the future – it will guide us for the reminds us that we are not working to these areas. implement the resolutions in the Strategic (see pages 7 and 8). This reminds us that next five years; but it also gave us a alone. Plan and to lay the ground for a united, striving to be exemplary science is a competitive business and sense of common purpose, as we held Excellence means striving to be enthusiastic working community. that it is important to have the best tools to several meetings and seminars during exemplary across the board – in The Institut Pasteur is one of those rare achieve success. Just as Pasteur inspired the process. The draft plan was Will the Strategic Plan be a driver finance, ethics, biosafety and IT. places which can offer solutions to the across the board – in Duclaux, who inspired Roux, who in turn presented to the Institut Pasteur for change and progress? Trust needs to be earned. We must inherent anxiety that comes with the job supported Yersin, the Institut Pasteur is a General Meeting and to our partners. not only guarantee compliance with of being a scientist. Indeed, the ambition ” place for training and passing on knowledge, The Strategic Plan concerns all of us, I am certain that it will. The hallmark the principles of ethics, scientific and, dare I say, success of the Institut finance, ethics, biosafety for spotting and inspiring talented young now and in the future. I would thank of outstanding research is being bold, integrity and professional conduct; Pasteur is in firmly dispelling the words scientists. That is why we set up 5-year our President, Professor Stewart Cole making changes that pave the way for we also need to think about how to of Robert Walser in The Tanners (1907): and IT. Trust needs units, which are specially designed to – and his team, especially François the architects of the future – people improve the quality of working life, “In this way, it seems to me, you will enable them to shine. In 2019, we will Romaneix and Olivier Schwartz –, like the famous Pasteurians Roux and how to cultivate employees’ interest perhaps find far more satisfaction in life continue to develop our site, because if who, a year into his term, kept on track Duclaux. We need to put our faith in and esteem for their work and than even the scholar who (though he to be earned. we want to achieve excellence, we need and delivered our roadmap within in new generations, new processes instill a sense of usefulness for human clearly recognizes the strings from which to remain one step ahead. the agreed timeframe by bringing (bioinformatics, artificial intelligence, health. Public health has always all lives and deeds depend) remains people together. etc.) and new geographical centers been a priority at the Institut Pasteur, chained to the narrow confines of his (Latin America, East Africa, etc.). involving our 14 National Reference study but nonetheless, as I can report In 2018, a new Strategic Plan was The Institut Pasteur has the freedom Centers (CNRs) and the Laboratory from experience, is often not so terribly How will the Institut Pasteur 2 also completed to ensure that the and ambition to be bold. It has changed for Urgent Response to Biological content.” At the Institut Pasteur, on the achieve the priorities over time: it no longer produces drugs Threats (CIBU) – which provided public contrary, we aim to make sure that our Institut Pasteur stays competitive. or vaccines and no longer has its own health expertise for health authorities scientists are both satisfied and proud What particularly stood out for you in the plan? hospital, but it is developing its network, worldwide in 2018 and will continue to contribute to our scientific and health its recruitments and its future priorities. to do so in the future. The Strategic missions. during the process? We will do so by focusing on the resources So we need to be bold, we need to Plan emphasizes the Institut Pasteur’s we have and the funds required. We know invest – including in areas that we might determination to enhance its research 1. In 2019 a draft decree is set to modernize efforts to combat mosquitoes in France, for the purposes of health The Board of Directors approached its that our resources are not limitless, even not have thought of ourselves –, potential in the areas covered by rather than human comfort (1964 decree). work on the Strategic Plan with enthusiasm. though the limits set for us by our donors and we need to seize opportunities for the CNRs. 2. Translated from the French for this annual report.
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