Laboratory Safety Manual

Laboratory Safety Manual CASE WESTERN RESERVE UNIVERSITY This document has been prepared by the Environmental Health and Safety Department and reviewed and approved by the Laboratory Safety Committee on July 31, 1991 Revised October 2005 Reviewed April 21, 2009 Revised November 23, 2009 Revised April, 2013 Revised June, 2013 Revised June, 2016 Page 1 SCOPE AND APPLICATION................................................................................................................... 4 CHEMICAL HYGIENE PLAN ................................................................................................................. 5 GENERAL CONSIDERATIONS ...................................................................................................... 9 CWRU SAFETY POLICY ........................................................................................................................ 9 RESPONSIBILITY ................................................................................................................................... 9 EMERGENCIES AND HAZARDOUS CHEMICAL SPILLS................................................................ 10 Emergencies ........................................................................................................................................ 10 Hazardous Chemical Spills ................................................................................................................. 11 Decontamination Procedures ............................................................................................................. 12 LABORATORY DECOMMISSIONING PROCEDURES ..................................................................... 13 SAFETY RULES FOR LABORATORIES ...................................................................................... 14 STANDARD OPERATING PROCEDURES .......................................................................................... 14 Introduction to Safe Laboratory Practices ......................................................................................... 14 Laboratory Practices for Specific Procedures .................................................................................... 18 PERSONAL PROTECTION: ADMINISTRATIVE CONTROLS, ENGINEERING CONTROLS, AND PPE .......................................................................................................................................................... 23 Introduction ........................................................................................................................................ 23 Administrative Controls ...................................................................................................................... 23 Engineering Controls .......................................................................................................................... 23 Personal Protective Equipment .......................................................................................................... 27 CHEMICAL STORAGE ......................................................................................................................... 30 General Rules ..................................................................................................................................... 30 Storage of Flammable Chemicals ....................................................................................................... 31 Storage of Corrosive Chemicals ......................................................................................................... 31 Hazardous Waste Storage ................................................................................................................... 32 CWRU HAZARD WARNING SIGNS .................................................................................................... 34 Description .......................................................................................................................................... 35 Policy .................................................................................................................................................. 35 Methods of Posting ............................................................................................................................. 35 NFPA Signage ..................................................................................................................................... 36 Availability of Signs ............................................................................................................................ 36 HEALTH HAZARDS ...................................................................................................................... 37 TOXICOLOGY ....................................................................................................................................... 37 General Definitions ............................................................................................................................. 37 Dose-Response Relationships ............................................................................................................. 37 Routes of Entry Into the Body ............................................................................................................. 37 Exposure Definitions ........................................................................................................................... 38 Other Factors Affecting Toxicity ......................................................................................................... 39 MATERIAL SAFETY DATA SHEETS .................................................................................................. 39 Definition and Policy .......................................................................................................................... 39 CLASSIFICATION OF TOXIC MATERIALS ....................................................................................... 39 Physical Classifications ...................................................................................................................... 39 Physiological Classifications .............................................................................................................. 40 WORKING SAFELY WITH HAZARDOUS CHEMICALS .................................................................. 43 Suggested References on Hazardous Chemicals ................................................................................. 43 PRADYOT PATNAIK, A COMPREHENSIVE GUIDE TO THE HAZARDOUS PROPERTIES OF CHEMICAL SUBSTANCES, 3RD EDITION, WILEY, 2007 .............................. 43 Hazardous Chemicals ......................................................................................................................... 44 Controlled Substances ........................................................................................................................ 45 Chemical Safety .................................................................................................................................. 45 Select Carcinogens, Reproductive Hazards, and Chemicals with a High Degree of Acute Toxicity .. 46 Creating a Designated Area ............................................................................................................... 46 Page 2 General Procedures ............................................................................................................................ 46 Operational Procedures ...................................................................................................................... 47 Working with Select Carcinogens ....................................................................................................... 48 Working with Reproductive Hazards .................................................................................................. 49 Working with Substances with High Acute Toxicity ............................................................................ 50 Experimentation with Animals ............................................................................................................ 50 ULTRAVIOLET RADIATION EXPOSURE ......................................................................................... 50 Effects of Exposure ............................................................................................................................. 50 Protection Against Ultraviolet Radiation Exposure ........................................................................... 50 BIOLOGICAL HAZARDS ..................................................................................................................... 51 Select Agent Program ......................................................................................................................... 51 WASTE DISPOSAL AND WASTE REDUCTION .......................................................................... 52 DISPOSAL OF CHEMICAL WASTE .................................................................................................... 52 Table of Incompatible Chemicals ....................................................................................................... 53 Disposal of Chemicals in Sanitary Sewers (Drains) ........................................................................... 57 DISPOSAL OF EXPLOSIVE OR EXTREMELY REACTIVE MATERIALS ....................................... 58 DISPOSAL OF SELECT AGENT ..........................................................................................................

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