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Diethyl Sulfate

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Diethyl Sulfate Diethyl sulfate sc-239740 Material Safety Data Sheet Hazard Alert Code EXTREME HIGH MODERATE LOW Key: Section 1 – CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Diethyl sulfate STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. NFPA FLAMMABILITY1 HEALTH3 HAZARD INSTABILITY1 SUPPLIER Santa Cruz Biotechnology, Inc. 2145 Delaware Avenue Santa Cruz, California 95060 800.457.3801 or 831.457.3800 EMERGENCY ChemWatch Within the US & Canada: 877–715–9305 Outside the US & Canada: +800 2436 2255 (1–800-CHEMCALL) or call +613 9573 3112 SYNONYMS C4-H10-O4-S, (C2H5)2SO4, "ethyl sulfate", DS, "diethyl tetraoxosulfate", "sulphuric acid diethyl ester", "sulfuric acid diethyl ester" Section 2 – HAZARDS IDENTIFICATION CHEMWATCH HAZARD RATINGS Min Max Flammability: 1 Toxicity: 3 Min/Nil=0 Body Contact: 3 Low=1 Reactivity: 1 Moderate=2 High=3 Chronic: 3 Extreme=4 CANADIAN WHMIS SYMBOLS EMERGENCY OVERVIEW 1 of 13 RISK Causes burns. Risk of serious damage to eyes. May cause CANCER. May cause heritable genetic damage. Harmful by inhalation, in contact with skin and if swallowed. POTENTIAL HEALTH EFFECTS ACUTE HEALTH EFFECTS SWALLOWED ! Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual. ! The material can produce chemical burns within the oral cavity and gastrointestinal tract following ingestion. ! Ingestion of acidic corrosives may produce burns around and in the mouth. the throat and esophagus. ! The material is a vesicant causing blistering on contact. ! Organo-sulfates are generally poorly absorbed from the gastrointestinal tract but have the ability to attract water and as a result may produce diarrhea. If absorbed they are highly toxic. EYE ! The material can produce chemical burns to the eye following direct contact. Vapors or mists may be extremely irritating. ! If applied to the eyes, this material causes severe eye damage. ! Direct eye contact with acid corrosives may produce pain, tears, sensitivity to light and burns. Mild burns of the epithelia generally recover rapidly and completely. ! Irritation of the eyes may produce a heavy secretion of tears (lachrymation). SKIN ! Skin contact with the material may be harmful; systemic effects may resultfollowing absorption. ! The material can produce chemical burns following direct contactwith the skin. ! Skin contact with acidic corrosives may result in pain and burns; these may be deep with distinct edges and may heal slowly with the formation of scar tissue. ! Solution of material in moisture on the skin, or perspiration, may markedly increase skin corrosion and accelerate tissue destruction. ! Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected. ! The material is a vesicant causing blistering on contact. INHALED ! If inhaled, this material can irritate the throat andlungs of some persons. ! Inhalation of aerosols (mists, fumes), generated by the material during the course of normal handling, may be harmful. ! Corrosive acids can cause irritation of the respiratory tract, with coughing, choking and mucous membrane damage. There may be dizziness, headache, nausea and weakness. CHRONIC HEALTH EFFECTS ! There is ample evidence that this material can be regarded as being able to cause cancer in humans based on experiments and other information. Based on experiments and other information, there is ample evidence to presume that exposure to this material can cause genetic defects that can be inherited. Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or biochemical systems. There is some evidence that inhaling this product is more likely to cause a sensitization reaction in some persons compared to the general population. Repeated or prolonged exposure to acids may result in the erosion of teeth, swelling and or ulceration of mouth lining. Irritation of airways to lung, with cough, and inflammation of lung tissue often occurs. When administered by subcutaneous injection, diethyl sulfate induced local sarcomas in rats. Subcutaneous injection of diethyl sulfate to pregnant rats induced malignant tumours of the nervous system in their off-spring. Following gavage in rats, several tumours developed in the forestomach. Section 3 – COMPOSITION / INFORMATION ON INGREDIENTS NAME CAS RN % diethyl sulfate 64–67–5 >98 hydrolysis produces ethyl hydrogen sulfate 540–82–9 further hydrolysis produces sulfuric acid 7664–93–9 ethanol 64–17–5 2 of 13 Section 4 – FIRST AID MEASURES SWALLOWED ! For advice, contact a Poisons Information Center or a doctor at once. Urgent hospital treatment is likely to be needed. EYE ! If this product comes in contact with the eyes: Immediately hold eyelids apart and flush the eye continuously with running water. Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by occasionally lifting the upper and lower lids. SKIN ! If skin or hair contact occurs: Immediately flush body and clothes with large amounts of water, using safety shower if available. Quickly remove all contaminated clothing, including footwear. INHALED ! If fumes or combustion products are inhaled remove from contaminated area. Lay patient down. Keep warm and rested. NOTES TO PHYSICIAN ! For acute or short term repeated exposures to strong acids: Airway problems may arise from laryngeal edema and inhalation exposure. Treat with 100% oxygen initially. Respiratory distress may require cricothyroidotomy if endotracheal intubation is contraindicated by excessive swelling Section 5 – FIRE FIGHTING MEASURES Vapour Pressure (mmHG): <0.0013 @ 20C Upper Explosive Limit (%): Not available Specific Gravity (water=1): 1.177 Lower Explosive Limit (%): 4.1 EXTINGUISHING MEDIA ! Foam. Dry chemical powder. FIRE FIGHTING ! Alert Emergency Responders and tell them location and nature of hazard. Wear full body protective clothing with breathing apparatus. When any large container (including road and rail tankers) is involved in a fire, consider evacuation by 800 metres in all directions. GENERAL FIRE HAZARDS/HAZARDOUS COMBUSTIBLE PRODUCTS ! Combustible. Slight fire hazard when exposed to heat or flame. Combustion products include: carbon dioxide (CO2), sulfur oxides (SOx), other pyrolysis products typical of burning organic material. May emit poisonous fumes. FIRE INCOMPATIBILITY ! Avoid contamination with oxidizing agents i.e. nitrates, oxidizing acids,chlorine bleaches, pool chlorine etc. as ignition may result. PERSONAL PROTECTION Glasses: Chemical goggles. Full face- shield. Gloves: 3 of 13 Respirator: Type AE-P Filter of sufficient capacity Section 6 – ACCIDENTAL RELEASE MEASURES MINOR SPILLS ! Remove all ignition sources. Clean up all spills immediately. MAJOR SPILLS ! Clear area of personnel and move upwind. Alert Emergency Responders and tell them location and nature of hazard. Section 7 – HANDLING AND STORAGE PROCEDURE FOR HANDLING ! DO NOT allow clothing wet with material to stay in contact with skin Avoid all personal contact, including inhalation. Wear protective clothing when risk of exposure occurs. RECOMMENDED STORAGE METHODS ! Glass container. Lined metal can, Lined metal pail/drum Plastic pail For low viscosity materials Drums and jerricans must be of the non-removable head type. Where a can is to be used as an inner package, the can must have a screwed enclosure. All inner and sole packagings for substances that have been assigned to Packaging Groups I or II on the basis of inhalation toxicity criteria, must be hermetically sealed. STORAGE REQUIREMENTS ! Store in original containers. Keep containers securely sealed. Section 8 – EXPOSURE CONTROLS / PERSONAL PROTECTION EXPOSURE CONTROLS TWA TWA STEL STEL Peak Peak TWA Source Material Notes ppm mg/m! ppm mg/m! ppm mg/m! F/CC US – Minnesota sulfuric acid Permissible Exposure 1 (Sulfuric acid) Limits (PELs) sulfuric acid Canada – British (Sulfuric acid, 0.2 Columbia Occupational A2, 1 Thoracic (M) Exposure Limits Revised 2004) TLV Basis: pulmonary US ACGIH Threshold sulfuric acid function. A2 = as 0.2 Limit Values (TLV) (Sulfuric acid) contained in strong inorganic acid mists US NIOSH sulfuric acid Recommended 1 (Sulfuric acid) Exposure Limits (RELs) 4 of 13 Canada – Alberta sulfuric acid Occupational Exposure (Sulphuric 1 3 Limits acid) US – Tennessee Occupational Exposure sulfuric acid 1 Limits – Limits For Air (Sulfuric acid) Contaminants US – Vermont Permissible Exposure sulfuric acid Limits Table Z-1-A 1 (Sulfuric acid) Transitional Limits for Air Contaminants US – Vermont Permissible Exposure sulfuric acid Limits Table Z-1-A Final 1 (Sulfuric acid) Rule Limits for Air Contaminants US – Idaho – Limits for sulfuric acid 1 Air Contaminants (Sulfuric acid) US – California Permissible Exposure sulfuric acid 1 3 Limits for Chemical (Sulfuric acid) Contaminants US – Hawaii Air sulfuric acid 1 3 Contaminant Limits (Sulfuric acid) US – Alaska Limits for sulfuric acid 1 Air Contaminants (Sulfuric acid) US – Michigan sulfuric acid Exposure Limits for Air 1 (Sulfuric acid) Contaminants Canada – Yukon Permissible sulfuric acid Concentrations for (Sulphuric – 1 – 1 Airborne Contaminant acid) Substances US – Washington Permissible exposure sulfuric acid 1 3 limits of air (Sulfuric
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