INNOVATORS REPORT 2013 Trends in North Carolina Entrepreneurship

2013 IPO WATCH

226 NATIONAL 9 STATEWIDE

1. Aerie Pharmaceuticals 26 2. ChannelAdvisor SOUTHEAST 3. Chimerix 4. Heat Biologics 5. LipoScience 6. Ply Gem Holdings 7. Quintiles 8. Regado Biosciences 9. Stock Building Supply

REPORT SOURCES: CED, National Association (NVCA), North Carolina Biotechnology Center, Ernst & Young, PricewaterhouseCoopers, SBIR.gov

The Innovators Report is made possible by generous gifts to the CED Annual Fund. Thank you to our many supporters! For more information on how to contribute, please visit www.cednc.org/donate. MAJOR MERGERS & NC EVENTS ACQUISITIONS* DSM Pharmaceuticals Patheon $2.6 billion

Santarus Salix Pharmaceuticals $2.6 billion COMPANY PRA International Kolberg, Kravis & Roberts $1.3 billion MILESTONES Solstas Lab Partners Quest Diagnostics $570 million Medicago Mitsubishi Tanabe Pharma $357 million

Recognized as Advanced Liquid Logic Illumina $96 million 50 million Named Cracks a “Disrupter” sponsored 2013 Top 50 for the wireless Exam Design Pearson VUE app installs Fierce in Digital industry by Top 15 Health Entrepreneur Magazine Geomagic 3D Systems GrassRoots Biotechnology Monsanto

Novella Clinical Quintiles

Secure Enterprise Computing Agio Technology Axial Republic Appia Scioderm Exchange Wireless Tekelec Oracle

ACQUIRED ACQUIRED BY *Partial listing DEALS & PARTNERSHIPS

Signs up Yahoo! Sports, Bloomberg, CBS and Gannett

$70 million deal with Toyama Chemical Company and a $58 million BARDA contact

CHATHAM THERAPEUTICS Signs major deal with Baxter International

Signs deal with Sanofi & Horizon Pharma

1 of 15 Google “Premier” Partners Lands $40 million contract with FDA 260 TOTAL INVESTMENTS

1 LIFE SCIENCE ...... $275,486,045 34 Equity...... $244,728,800 Grants/Awards...... $30,757,245

Biopharma: 62 deals • Medtech: 49 deals • Other: 23 deals

TECH ...... $116,873,094 Equity...... $116,139,075 106 Grants/Awards...... $508,230 ...... $225,789

ADVANCED MANUFACTURING.....$68,709,235 Equity...... $68,039,235 19 Grants/Awards...... $670,000

OTHER Equity...... $173,107 1 TOTAL MONEY RAISED $461,241,481 WHO’S INVESTING: 108 TOTAL UNIQUE FUNDERS*

3G Capital Hatteras Venture Partners MCG Capital Corporation North Carolina Postcode Lottery ABS Capital Partners Healthbox Medimmune LLC Biotechnology Center Green Challenge Acadia Woods Partners HIG Capital Michael J. Fox Foundation Novak Biddle Venture Partners PTV Sciences Acorn Innovestments IDEA Fund Partners Morgenthaler Ventures Novartis Venture Funds QuestMark Partners, LP Aisling Capital IMAF-Cape Fear Morningside Technologies Novel TMT Ventures Ltd Relevance Capital Inc. Allscripts Open App Challenge IMAF-RTP Mountain Group Capital NSF Revolution Growth Fund Independence Blue Cross Pappas Ventures Rex Health Ventures American Heart Association’s Science 3 CANADA River Cities Capital Funds & Technology Accelerator Program Riverside Partners ARCH Venture Partners MIDWEST NORTHEAST RiverVest Venture Partners Bay Area Lyme Foundation RTP Capital Biogenerator and The Helix Fund S-Grupp Capital Management of St. Louis, Missouri SJF Ventures BlueTree Allied Angels Southern Capitol Ventures Brenden Family Growth Fund Spray Venture Partners Broadview Ventures 1 SEATTLE Sumitomo Corp Bull City Venture Partners 10 24 Synergy Life Science Partners Camden Partners Syngenta Ventures Canaan Partners CALIFORNIA 10 26 3 ASIA NORTH CAROLINA EUROPE Capital Communications CDPQ Inc. 7 Care Capital Carmel Ventures CDP Capital 10 Tech Stars Chicago Contender Capital Technology Partners Domain Associates Terracap Ventures DreamIT Ventures 14 The 3x5 Special Opportunity Fund E Merge SA The Aurora Funds FCA Venture Partners SOUTHEAST The Missouri Technology FINISTERE VENTURES Corporation FirstMark Capital Triangle Angel Partners Fletcher Spaght Ventures Innotech Advisers MID-ATLANTIC Triangle Startup Factory Forbion Capital Partners Intel Capital Corp Triathlon Medical Ventures Fortis Capital Holdings Intersouth Partners TVC Capital Fulcrum Equity Partners Life Science Angels MPM Capital LLC Patient-Centered Outcomes TVM Capital GmbH Gemini Israeli Ventures Lookout Capital MSouth Equity Partners Research Institute UNC Carolina Kickstart Globespan Capital Partners Lord Capital NCIDEA Pearl Street Venture Funds Commercialization Award Grotech Ventures Lumira Capital Corp New Enterprise Associates Piedmont Angel Network Ventech SA Harbert Venture Partners Madison River Ventures NIH Plexus Capital Wakefield Group Harris & Harris Group Massey Burch Capital Corporation North Atlantic Capital WRD Capital

*Institutional investors only