Nina Vachnadze

Total Page:16

File Type:pdf, Size:1020Kb

Nina Vachnadze nina vachnadze Personal information Contact Details ID Number: 01006003225 Email address: [email protected] Full name: nina vachnadze Call number: 598219323 Gender: Female Country: საქართველო (Georgia) Date of birth: 21.01.1963 City: Tbilisi Citizenship: საქართველო (Georgia) Address: Tbilisi 0159, p.Sarajishvili 36 st. Languages Language Writing Reading Speaking ქართული (Georgian) B2 B2 B2 English B1 B1 B1 Russian C2 C2 C2 Education Academic degree Academic Degree: Doctoral/PhD, Ed.D or other equivalent Year obtained: 06.10.2008 Education Start End Academic Degree Name of the Institution Country Major discipline year year Doctoral/PhD, Ed.D or other equivalent Georgian Technical University 2005 Master/MS, MA, MR, MBA, m.Ed or other Ivane Javakhishvili Tbilisi State special Nuclear equivalent University physics 1982 1987 Scientific Fields Main Field Field: 3. Medical and health sciences Sub-Field: 3.1 Basic medicine Subject area: 3.1.5 Pharmacology and pharmacy Additional Field (1) Field: 3. Medical and health sciences Sub-Field: 3.3 Health sciences Additional Field (2) Field: 3. Medical and health sciences Employment History Current place(s) of employment Start Workplace Name of the work department Position Main responsibilities Date TSMU, Iovel TSMU, Iovel Kutateladze Institute of Phytochemical study of local and introduced plants Kutateladze Institute Pharmacochemistry, Department of Chief in Georgia on alkaloids content and evaluation of 16.09.1987 of Pharmacochemistry Phytochemistry, Alkaloids direction Scientist their biological and pharmacological activities. Work experience Start Company/Institution Name of the department Position Main responsibilities Date End Date TSMU, Iovel Kutateladze Institute Phytochemical study of local and TSMU, Iovel Kutateladze of Pharmacochemistry, Chief introduced plants in Georgia on alkaloids Institute of Department of Phytochemistry, Scientist content and evaluation of their biological 01.08.2018 დღემდე Pharmacochemistry Alkaloids direction and pharmacological activities TSMU, Iovel Kutateladze Institute Phytochemical study of local and TSMU, Iovel Kutateladze of Pharmacochemistry, science introduced plants in Georgia on alkaloids Institute of Department of Phytochemistry, worker content and evaluation of their biological 09.08.201401.08.2018 Pharmacochemistry Alkaloids direction and pharmacological activities. Iovel Kutateladze Institute Phytochemical study of local and of Pharmacochemistry of the Iovel Kutateladze Institute of Senior introduced plants in Georgia on alkaloids Georgian Academy of Pharmacochemistry, Alkaloids Lab content and evaluation of their biological 02.09.200321.07.2006 Sciences Lab Assistant and pharmacological activities. Iovel Kutateladze Institute of Pharmacochemistry of the Iovel Kutateladze Institute of Senior Processing of chemical analysis and Georgian Academy of Pharmacochemistry, Laboratory Lab process results 12.03.199013.10.1997 Sciences of Analytical Chemistry Assistant Iovel Kutateladze Institute Assisted in spectral methods for the of Pharmacochemistry of the Iovel Kutateladze Institute of determination of the structural structure Georgian Academy of Pharmacochemistry, Nuclear Assistant of the substance and the decoding of the 16.09.198712.03.1990 Sciences Magnetic Resonance Lab spectrum. Scientific Productivity Patents Year of Patent name Issuing organization Registration number Issue The method of obtaining State Committee of Inventions and Discoveries of the USSR საავტორო უფლებების Berberine sulfate Council of Ministers მოწმობა N 1757675 1992 Article / Monograph / Manual Type Authors Publication title Source title Year N. Vachnadze, V. Vachnadze,T. Pharmacological active alkaloids, Vinca Article Suladze, Q. Mchedlidze, herbacea Waldst. et Kit., Peganum harmala L., Metabolomic and quality of life, 234-238 2019 M.Sulakvelidze, V. Mshvildadze growing in Georgia N.Vachnadze, T.Suladze, Phytochemical Screening of Plants of the genus Experimental and clinical medicine, №5, 22- Article V.Vachnadze Magnolia Introduced into Western Georgia 25 2018 N.Vachnadze, V.Vachnadze, Biologically active alkaloids from rhzomes Georgian Medical news(GMN), №10(271), Article N.Gogitidze, N.Mushkiashvili, with roots of Vinca herbacea Waldst et Kit, 122-126 2017 Q.Mchedlidze, Growing in Georgia N.Vachnadze, V.Vachnadze Some alkaloid containing plants grownand in Article Q.Mchedlidze T.Suladze traduced in Georgia and their biological Experimental and clinical medicine, №3, 31- 2017 V.Mshvildadze L.Kintsurashvili activities 37 N.Vachnadze, V.Vachnadze, Screening of wild spread and cultivated of Article Q.Mchedlidze, T.Suladze, Buxus colchica Pojark growing in Georgia on Georgian Medical news(GMN), 2016, №7- 2016 J.Novikova the content of alkaloids and biological activity 8(256-257), 82-87 Type Authors Publication title Source title Year N.Vachnadze, V.Vachnadze Alkaloda Peganum harmala L. and their Georgian Medical news (GMN), №6 (243), Article L.Kintsurashvili T.Suladze biological activity 79-81 2015 J.Novikova N.Vachnadze, N.Tabatadze, B.Tabidze, M.Getia, Chemical content and pharmacological active Experimental and clinical medicine, №4, 93- Article N.Gogitidze, V.Mshvildadze, compounds from the roots of Cephalaria 97 2014 G.Dekanosidze Gigantea (Ledeb.) growing in Georgia N.Vachnadze, B.Kikalishvili, Fatty acid composition in the oil of the grass Article D.Zurabashvili, D.Turabelidze, Vinca minor and Vinca herbacea, native to CHEMISTRY OF NATURAL 2013 Ts.Sulakvelidze M.Malania Georgia COMPOUNDS, №6, 961 N.Vachnadze, V.Vachnadze, Article L.Kintsurashvili, T.Suladze, Alkaloids of Vinca rosea L. introduced in Georgian Medical news(GMN), №11(224), 2013 A.Bakuridze. Western Georgia 85-88 N.Vachnadze, V. Vachnadze, Article A.Bozhadze, D. Berashvili, Alkaloids from Chelidonium Majus, growing CHEMISTRY OF NATURAL 2012 A.Bakuridze. in Georgia COMPOUNDS, v.45, №5, 291 N.Vachnadze, M.Mesxeli, Article V.Vachnadze, D.Berashvili, Phellodendrin from Phellodendron lavallei, CHEMISTRY OF NATURAL COMPOUND, 2011 A.Bakuridze introduced to Georgia 2011, №3, 424-426 N.Vachnadze, N.Gagua, Extraction of pharmacologically active Georgian Medical news (GMN), №6(195), Article A.Bakuridze, V. Vachnadze, 2011 D.Berashvili alkaloids from Vinca species 105-110 Fatty acid composition of the oil of greater N.Vachnadze, B.Kikalishvili, celandine (Chelidonium majus L.) and its Georgian Medical news(GMN), №9 (198), Article D.Zurabashvili, Z.Zurabashvili, biological activity in the form of a food 72-75 2011 I.Giorgobiani additive N.Vachnadze, M.Mesxeli, Alkaloids Phellodendron lavallei, introduced CHEMISTRY OF NATURAL COMPOUN, Article V.Vachnadze, A.Bakuridze in western Georgia №1, 137-139 2011 N.Vachnadze, N.Gagua, Vingerbin: an indolin alkaloid preparation Allergology and Immunology, , v.11, №2, Article A.Bakuridze, G.Chkhikvadze, V. with antiarrhythmic activity produced of 2010 Vachnadze Vinca herbacea Waldst. Et Kit. 160-162 N.Vachnadze, I.Sixarulidze, Article N.Gogitidze, N.Mushkiashvili, Anticonvulsant from the capula of the giant Allergology and Immunology, v.11, №2, 2010 M.Gabelaia, G.Dekanosidze Cephalaria Gigantea (Ledeb.) 170-171 N.Vachnadze, V.Vachnadze, Alkaloids Buxus Colchika, B.Sempervines, CHEMISTRY OF NATURAL Article E.Jakeli, D.Tsakadze B.Baliarika, growing in Georgia. COMPOUNDS, №6, 779-780 2009 N.Vachnadze, V.Vachnadze, E.Jakeli. D.Tsakadze, Steroidal alkaloids from the leaves of Buxus Compounds and Materials with Specific Article Sh.Samsonia, Zh.Novikova, colchica: structure and pharmacology Properties Editors: B.A. Howell et al., New 2008 M.Mulkijanyan York, Nova Science Publishers, Inc., 153-160 Participation in scientific events Scientific event name Title of the presentation Event venue Year International Conference "Metabolomic and Pharmacological active alkaloids Vinca herbacea Waldst. et quality of life" Kit and Peganum harmala L., growing in Georgia Moscow, Russia 2019 Phytochemical screening of plants of the genus Magnolia, X International Conference "Health and Ecology" introduced into Western Georgia Telavi, Georgia 2018 Scientific conference on natural and synthetic Some monomeric alkaloids of Vinca rosea L. introduced in biologically active compounds western Georgia Tbilisi, Georgia 2018 Study on cytotoxic activity of some extracts of Vinca rosea L. Internnational conference Analytical chemistry introduced to Western Georgia Spain, Madrid 2018 Some alkaloid-containing plant species growing and IX International Conference "Health and Ecology" introduced in Georgia and their biological activity Mtskheta, Georgia 2017 Tashkent, 12-th International Symposium on the Chemistry Plants of the genus Magnolia introduced in Adjara (Georgia) as Republic 2017 of natural Compounds potential sources of biologically active alkaloids Uzbekistan საერთაშორისო კონფერენცია მომავლის Study of cytotoxic activities of alkaloids from medicinal plants Batumi, Georgia 2017 ტექნოლოგიები და სიცოცხლის ხარისხი. growing in Georgia Modern researches and prospects of their use in Technological process of liquid-liquid extraction of indole chemistry, chemical engineering and related fields group alkaloids Ureki, Georgia 2016 Scientific event name Title of the presentation Event venue Year Scientific Conference on Natural and Synthetic Cytotoxic activity of some indol and isoquinoline alkaloids of Biologically Active compounds genus Vinca, Magnolia and Chelidonium growing in Georgia Tbilisi, Georgia 2016 VIII Georgian National Congress of Allergy, Asthma and immunology Peganum Harmala L. alkaloids
Recommended publications
  • Molecular Identification of Commercialized Medicinal Plants in Southern Morocco
    Molecular Identification of Commercialized Medicinal Plants in Southern Morocco Anneleen Kool1*., Hugo J. de Boer1.,A˚ sa Kru¨ ger2, Anders Rydberg1, Abdelaziz Abbad3, Lars Bjo¨ rk1, Gary Martin4 1 Department of Systematic Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden, 2 Department of Botany, Stockholm University, Stockholm, Sweden, 3 Laboratory of Biotechnology, Protection and Valorisation of Plant Resources, Faculty of Science Semlalia, Cadi Ayyad University, Marrakech, Morocco, 4 Global Diversity Foundation, Dar Ylane, Marrakech, Morocco Abstract Background: Medicinal plant trade is important for local livelihoods. However, many medicinal plants are difficult to identify when they are sold as roots, powders or bark. DNA barcoding involves using a short, agreed-upon region of a genome as a unique identifier for species– ideally, as a global standard. Research Question: What is the functionality, efficacy and accuracy of the use of barcoding for identifying root material, using medicinal plant roots sold by herbalists in Marrakech, Morocco, as a test dataset. Methodology: In total, 111 root samples were sequenced for four proposed barcode regions rpoC1, psbA-trnH, matK and ITS. Sequences were searched against a tailored reference database of Moroccan medicinal plants and their closest relatives using BLAST and Blastclust, and through inference of RAxML phylograms of the aligned market and reference samples. Principal Findings: Sequencing success was high for rpoC1, psbA-trnH, and ITS, but low for matK. Searches using rpoC1 alone resulted in a number of ambiguous identifications, indicating insufficient DNA variation for accurate species-level identification. Combining rpoC1, psbA-trnH and ITS allowed the majority of the market samples to be identified to genus level.
    [Show full text]
  • Long-Lasting Analgesic Effect of the Psychedelic Drug Changa: a Case Report
    CASE REPORT Journal of Psychedelic Studies 3(1), pp. 7–13 (2019) DOI: 10.1556/2054.2019.001 First published online February 12, 2019 Long-lasting analgesic effect of the psychedelic drug changa: A case report GENÍS ONA1* and SEBASTIÁN TRONCOSO2 1Department of Anthropology, Philosophy and Social Work, Universitat Rovira i Virgili, Tarragona, Spain 2Independent Researcher (Received: August 23, 2018; accepted: January 8, 2019) Background and aims: Pain is the most prevalent symptom of a health condition, and it is inappropriately treated in many cases. Here, we present a case report in which we observe a long-lasting analgesic effect produced by changa,a psychedelic drug that contains the psychoactive N,N-dimethyltryptamine and ground seeds of Peganum harmala, which are rich in β-carbolines. Methods: We describe the case and offer a brief review of supportive findings. Results: A long-lasting analgesic effect after the use of changa was reported. Possible analgesic mechanisms are discussed. We suggest that both pharmacological and non-pharmacological factors could be involved. Conclusion: These findings offer preliminary evidence of the analgesic effect of changa, but due to its complex pharmacological actions, involving many neurotransmitter systems, further research is needed in order to establish the specific mechanisms at work. Keywords: analgesic, pain, psychedelic, psychoactive, DMT, β-carboline alkaloids INTRODUCTION effects of ayahuasca usually last between 3 and 5 hr (McKenna & Riba, 2015), but the effects of smoked changa – The treatment of pain is one of the most significant chal- last about 15 30 min (Ott, 1994). lenges in the history of medicine. At present, there are still many challenges that hamper pain’s appropriate treatment, as recently stated by American Pain Society (Gereau et al., CASE DESCRIPTION 2014).
    [Show full text]
  • Alhagi Maurorum
    Prepared By Jacob Higgs and Tim Higgs Class 1A EDRR- Early Detection Rapid Response Watch List Common crupina Crupina vulgaris African rue Peganum harmala Small bugloss Anchusa arvensis Mediterranean sage Salvia aethiopis Spring millet Milium vernale Syrian beancaper Zygophyllum fabago North Africa grass Ventenata dubia Plumeless thistle Carduus acanthiodes Malta thistle Centaurea melitensis Common Crupina Crupina vulgaris African rue Peganum harmala Small bugloss Anchusa arvensis Mediterranean sage Salvia aethiopis Spring millet Milium vernale Syrian beancaper Zygophyllum fabago North Africa grass Ventenata dubia Plumeless thistle Carduus acanthiodes Malta thistle Centaurea melitensis m Class 1B Early Detection Camelthorn Alhagi maurorum Garlic mustard Alliaria petiolata Purple starthistle Cantaurea calcitrapa Goatsrue Galega officinalis African mustard Brassica tournefortii Giant Reed Arundo donax Japanese Knotweed Polygonum cuspidatum Vipers bugloss Echium vulgare Elongated mustard Brassica elongate Common St. Johnswort Hypericum perforatum L. Oxeye daisy Leucanthemum vulgare Cutleaf vipergrass Scorzonera laciniata Camelthorn Alhagi maurorum Garlic mustard Alliaria petiolata Purple starthistle Cantaurea calcitrapa Goatsrue Galega officinalis African mustard Brassica tournefortii Giant Reed Arundo donax Japanese Knotweed Polygonum cuspidatum Vipers bugloss Echium vulgare Elongated mustard Brassica elongate Common St. Johnswort Hypericum perforatum L. Oxeye daisy Leucanthemum vulgare Cutleaf vipergrass Scorzonera laciniata Class 2 Control
    [Show full text]
  • Antimicrobial Activity of Peganum Harmala Fixed Oil.Pdf
    ﺑﺴﻢ اﷲ اﻟﺮﺣﻤﻦ اﻟﺮﺣﯿﻢ Sudan University of Science and Technology Faculty of Science Department of Chemistry Antimicrobial Activity of Peganum Harmala Fixed Oil A Dissertation Submitted in Partial Fulfillment of the Requirements of the B.Sc (Hons.) Degree in Chemistry By: Elamein Elsadig Hamad Ismaeel Mergany Elnayer Osman Fathalrahman Mohamed Supervisor: Prof. Mohamed Abdel Karim Mohamed Oct.2016 1-Introduction 1.1-Natural products A natural product is a chemical compound or substance produced by a living organism—that is, found in nature.[2][3] In the broadest sense, natural products include any substance produced by life.[4][5] Natural products can also be prepared by chemical synthesis (both semi- synthesis and total synthesis) and have played a central role in the development of the field of organic chemistry by providing challenging synthetic targets. The term natural product has also been extended for commercial purposes to refer to cosmetics, dietary supplements, and foods produced from natural sources without added artificial ingredients.[6]Within the field of organic chemistry, the definition of natural products is usually restricted to mean purified organic compounds isolated from natural sources that are produced by the pathways of primary or secondary metabolism.[7] Within the field of medicinal chemistry, the definition is often further restricted to secondary metabolites.[8][9] Secondary metabolites are not essential for survival, but nevertheless provide organisms that produce them an evolutionary advantage.[10] Many secondary metabolites are cytotoxic and have been selected and optimized through evolution for use as 1 "chemical warfare" agents against prey, predators, and competing organisms.[11] Natural products sometimes have pharmacological or biological activity that can be of therapeutic benefit in treating diseases.
    [Show full text]
  • Switch to Mania After Ayahuasca Consumption in a Man with Bipolar Disorder: a Case Report Alejandro G Szmulewicz1,2*, Marina P Valerio1 and Jose M Smith1
    Szmulewicz et al. International Journal of Bipolar Disorders (2015) 3:4 DOI 10.1186/s40345-014-0020-y CASE REPORT Open Access Switch to mania after ayahuasca consumption in a man with bipolar disorder: a case report Alejandro G Szmulewicz1,2*, Marina P Valerio1 and Jose M Smith1 Abstract Background: There is an increasing use of ayahuasca for recreational purposes. Furthermore, there is a growing evidence for the antidepressant properties of its components. However, there are no reports on the effects of this substance in the psychiatric setting. Harmaline, one of the main components of ayahuasca, is a selective and reversible MAO-A inhibitor and a serotonin reuptake inhibitor. Case report: We present the case of a man with bipolar disorder who had a manic episode after an ayahuasca consumption ritual. This patient had had at least one hypomanic episode in the past and is currently depressed. We discuss the diagnostic repercussion of this manic episode. Conclusion: There is lack of specificity in the diagnosis of substance-induced mental disorder. The knowledge of the pharmacodynamic properties of ayahuasca consumption allows a more physiopathological approach to the diagnosis of the patient. Keywords: Ayahuasca; Bipolar disorder; DSM 5; Switch to mania; MAO inhibitors Background oral biodisponibility increases, this interaction being the Ayahuasca is a psychotropic, hallucinogenic beverage, base of ayahuasca psychotropic effect (McKenna 2004). composed of a mixture of Amazonian plants. It is usu- ally consumed as an infusion with Banisteriopsis caapi Case presentation Psychotria viridis and (Guimaraes dos Santos 2010). The We present the case of a 30-year-old Argentinian man, B.
    [Show full text]
  • Lali Kintsurashvili
    Lali Kintsurashvili Personal information Contact Details ID Number: 01024041567 Email address: [email protected] Full name: Lali Kintsurashvili Call number: 599407944 Gender: Female Country: საქართველო (Georgia) Date of birth: 04.09.1958 City: Tbilisi Citizenship: საქართველო (Georgia) Address: Tbilisi 0159, P. Sarajishvili 36 st. Languages Language Writing Reading Speaking French A1 A2 A1 Latin B1 B1 A2 Russian C2 C1 C2 English B1 B1 B1 ქართული (Georgian) C2 C2 C2 Education Academic degree Academic Degree: Doctoral/PhD, Ed.D or other equivalent Year obtained: 24.12.1997 Education Start End Academic Degree Name of the Institution Country Major discipline year year Doctoral/PhD, Ed.D or Institute of Pharmacochemistry Georgian საქართველო Pharmacy: Pharmaceutical chemistry 1982 1986 other equivalent Academy of Sciences (postgraduate studies) (Georgia) and Pharmakognosy, restr. 15.00.02 Master/MS, MA, MR, MBA, m.Ed or other Tbilisi State Medical Institute საქართველო Pharmacy 1976 1981 equivalent (Georgia) Projects Completed projects Project Start Project title Position head Date End Date Donor N 843/07 In Georrgian National Scientific fund financed by the cjmpetition GNSF/ ST06/6-102" Blood formation organ function assistant Inga Iovel Kutateladze sttimulatory vegetable containing of alkaloid new drug form shapes performerdadeshidze10.04.200625.12.2008 institute of of foundation biodegradable Pharmakochhhhhhemistry Scientific Fields Main Field Field: 3. Medical and health sciences Sub-Field: 3.1 Basic medicine Subject area: 3.1.5 Pharmacology and pharmacy Employment History Current place(s) of employment Name of the Workplace work Position Main responsibilities Start department Date Tbilisi State Department of The study of Georgian flora on alkaloids composition and detection of Medical university Phytochemistry, senior biologically and pharmcologically active substances.
    [Show full text]
  • African Rue Peganum Harmala
    African rue Other common names: wild rue, rue weed, USDA symbol: PEHA Peganum harmala and Syrian rue ODA rating: A and T Introduction: African rue is native to the deserts of Africa and southern Asia. There are known sites in New Mexico, Arizona, Texas, California, Oregon and Washington. Introduced from the Mediterranean region and Middle East. The plant was first recognized in the United States in 1920 near Deming, New Mexico and has naturalized in parts of southwestern United States including Arizona, New Mexico, and parts of west Texas. Dehulled seeds yield edible oil similar to cottonseed oil. Plants have been used medicinally and produce red dye in the Middle East. Distribution in Oregon: The first documented site in Oregon was 1967 in Crook County. In 2008, African rue was identified in Harney County. For a collection of spatial information on the distribution of this plant in Oregon, go to Oregon WeedMapper Description: African rue is a multi-branched and bushy perennial. A member of the Caltrop family, it is a succulent plant, with bright green alternating leaves that are smooth and finely divided with long, narrow segments. Plants grow 1.5 feet tall and 3-4 feet in diameter. Flowers are white with five individual petals and are present in spring to early fall. Fruit is located in a leathery capsule 2-4 celled that contains 45-60 seeds. Seeds are angular, dark brown and have a distinctive smell. When crushed, the stems also have a disagreeable odor. The base of this plant is woody and roots can branch and reach 20 feet in depth.
    [Show full text]
  • Chemistry, Pharmacology and Medicinal Properties of Peganum Harmala L
    African Journal of Pharmacy and Pharmacology Vol. 6(22), pp. 1573-1580, 15 June, 2012 Available online at http://www.academicjournals.org/AJPP DOI: 10.5897/AJPP11.876 ISSN 1996-0816 ©2012 Academic Journals Review Chemistry, pharmacology and medicinal properties of Peganum harmala L. Jinous Asgarpanah and Fereshteh Ramezanloo Department of Pharmacognosy, Pharmaceutical Sciences Branch, Islamic Azad University (IAU), Tehran, Iran. Accepted 16 March, 2012 Peganum harmala L. is known as Syrian rue, Wild rue and Harmal. P. harmala extracts are considered important for drug development, because they are reported to have numerous pharmacological activities in the Middle East, especially in Iran and Egypt. For a long time P. harmala has been used in traditional medicines for the relief of pain and as an antiseptic agent. P. harmala also have antibacterial, antifungal, antiviral, antioxidant, antidiabetic, antitumor, antileishmanial, insecticidal and cytotoxic activities and hepatoprotective and antinociceptive effects. Harmaline, harmine, harmalol, harman, quinazoline derivatives, vasicine, vasicinone, anthroquinons and fixed oils are reported from seeds and roots of this plant. This plant is used as a medicine in Turkey, Syria, Iran, Pakistan, India, Egypt and Spain. This article presents comprehensive analyzed information on the botanical, chemical and pharmacological aspects of P. harmala. Key words: Peganum harmala, Zygophyllaceae, phytochemical, pharmacological properties. INTRODUCTION Peganum harmala commonly known as Syrian rue and many-branched stems may have a spread of four feet or Wild rue is a flowering plant and is widely distributed in more, the plant is rarely over two feet tall and generally the Central Asia, North Africa and Middle East. It has also appears round and bushy in habit.
    [Show full text]
  • Phytochemical Screening, Total Phenolics and Biological Activities of Tunisian Peganum Harmala Seed Extracts
    Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2017, 9(2):32-39 ISSN : 0975-7384 Research Article CODEN(USA) : JCPRC5 Phytochemical Screening, Total Phenolics and Biological Activities of Tunisian Peganum harmala Seed Extracts Maroua Khadhr1,2*, Dalila Bousta2, Hanane El Hajaji3, Mohammed Lachkar3, Hassan Barkai4, Saad Ibnsouda-Koraichi4 and Sadok Boukhchina1 1Biochemistry of Lipids and proteins Unit, Department of Biology, Faculty of Sciences of Tunis El Manar II 2092, Tunisia 2Laboratory of Pharmaco-Toxicology, National Agency of Medicinal and Aromatic Plants, Morocco 3Engineering of Organometallic and Molecular Materials Laboratory, Faculty of Sciences, University Sidi Mohamed Ben Abdellah, Morocco 4Laboratory of Microbial Biotechnology, Faculty of Science and Technology, Morocco _____________________________________________________________________________ ABSTRACT Peganum harmala, belonging to Zygophyllaceae family, is a herb with medicinal properties. This study evaluates the antioxidant activity of Tunisian Peganum harmala seed extracts obtained by two methods of extraction. The antimicrobial activity was also evaluated. The antioxidant activity of the extracts of Peganum harmala was studied by three different methods, including scavenging activity by DPPH, phosphomolybdenum method and reducing power of iron. The antimicrobial activity was evaluated using the broth microdilution assay. Results show that extract concentration was directly proportional to the antioxidant activity and the extracts of the maceration extraction showed a higher antioxidant activity than that in extracts of the soxhlet extraction. At all concentrations compared with BHT, the hexane extract have a higher antioxidant activity than those of all extracts of Peganum harmala seeds. For the phosphomolybdenum method, all the extracts showed an increase in antioxidant capacity with an increase in dose.
    [Show full text]
  • Peganum Harmala Extract Has Antiamoebic Activity to Acanthamoeba Triangularis Trophozoites and Changes Expression of Autophagy-Related Genes
    pathogens Article Peganum harmala Extract Has Antiamoebic Activity to Acanthamoeba triangularis Trophozoites and Changes Expression of Autophagy-Related Genes Rachasak Boonhok 1, Suthinee Sangkanu 2, Julalak Chuprom 2, Mayuna Srisuphanunt 1, Roghayeh Norouzi 3 , Abolghasem Siyadatpanah 4, Farzaneh Mirzaei 5, Watcharapong Mitsuwan 6 , Sueptrakool Wisessombat 1, Maria de Lourdes Pereira 7 , Mohammed Rahmatullah 8 , Polrat Wilairatana 9,* , Christophe Wiart 10, Lim Chooi Ling 11, Karma G. Dolma 12 and Veeranoot Nissapatorn 1,2,* 1 Department of Medical Technology, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, Thailand; [email protected] (R.B.); [email protected] (M.S.); [email protected] (S.W.) 2 Research Excellence Center for Innovation and Health Products (RECIHP), School of Allied Health Sciences, Southeast Asia Water Team (SEA Water Team) and World Union for Herbal Drug Discovery (WUHeDD), Walailak University, Nakhon Si Thammarat 80160, Thailand; [email protected] (S.S.); [email protected] (J.C.) 3 Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz 5166616471, Iran; [email protected] 4 Ferdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand 9717853577, Iran; Citation: Boonhok, R.; Sangkanu, S.; [email protected] 5 Chuprom, J.; Srisuphanunt, M.; Department Parasitology and Mycology, School of Medicine, Shahid Sadoughi University of Medical Norouzi, R.; Siyadatpanah, A.; Sciences, Yazd 14188-15971, Iran; [email protected] 6 Akkhraratchakumari Veterinary College and Research Center of Excellence in Innovation of Essential Oil, Mirzaei, F.; Mitsuwan, W.; Walailak University, Nakhon Si Thammarat 80160, Thailand; [email protected] Wisessombat, S.; 7 CICECO-Aveiro Institute of Materials and Department of Medical Sciences, University of Aveiro, de Lourdes Pereira, M.; et al.
    [Show full text]
  • Researches on the Germination Biology of Some Common Weed Seeds in Turkey
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE Researches on the Germination Biology of Some Common Weed Seeds in Turkey 1 2* 2 Hüseyin1 SOLAK , Murat KARACA , Ahmet GÜNCAN 2 Ziraat Bank, Konya, Turkey [email protected] Department of Plant Protection. University of Selcuk, Konya, Turkey *Corresponding author: Bulletin USAMV series Agriculture 72(2)/2015 Print ISSN 1843-5246; Electronic ISSN 1843-5386 DOI 10.15835/buasvmcn-agr: 10407 ABSTRACT Weeds in agricultural production is one of the most important factors affecting yield. They causes yield lose ranging from 25% to 35% by competing with cultivated plants especially for nutrient, water, light and place. This data show the significance of weeds in agricultural areas. It is necessary to control the weeds to remove their harm. Principally the meaning of control is to know their biology. With this research the germination biology conditions (minimum, optimum and maximum germination temperature, germination period and rate) of some common weeds that are widespreadAmaranthus inretroflexus the agriculture in Turkey have been examined.Chenopodium According to album the research results, minimum, optimum andAlhagi maximum camelorum germination temperatures were 7-10 °C, 30-40 °C and 43-45°C (no germination at 45 °C) for Galium aparine L., respectively. These parameters for L. were for0–2 Taraxacum °C, 15–25 °C officinale and 40 °C; for Fisch. (without fruit) theyHeliotropium were 7–10 °C, europaeum 25–40 °C and 40–43 °C (no germination at 43 °C); for L. they were 0–2Peganum °C, 5–25 harmala °C and 25–30 °C ( no germination at 30 °C); Weber.
    [Show full text]
  • New Mexico Noxious Weed List Updated September 2016
    New Mexico Noxious Weed List Updated September 2016 Class A Species Class A species are currently not present in New Mexico, or have limited distribution. Preventing new infestations of these species and eradicating existing infestations is the highest priority. Common Name Scientific Name Alfombrilla Drymaria arenariodes Black henbane Hyoscyamus niger Brazillian egeria Egeria densa Camelthorn Alhagi psuedalhagi Canada thistle Cirsium arvense Dalmation toadflax Linaria dalmatica Diffuse knapweed Centaurea diffusa Dyer’s woad Isatis tinctoria Giant salvinia Salvinia molesta Hoary cress Cardaria spp. Leafy spurge Euphorbia esula Oxeye daisy Leucanthemum vulgare Purple loosestrife Lythrum salicaria Purple starthistle Centaurea calcitrapa Ravenna grass Saccharum ravennae Scentless chamomile Matricaria perforata Scotch thistle Onopordum acanthium Spotted knapweed Centaurea biebersteinii Yellow starthistle Centaurea solstitialis Yellow toadflax Linaria vulgaris Class B Species Class B Species are limited to portions of the state. In areas with severe infestations, management should be designed to contain the infestation and stop any further spread. Common Name Scientific Name African rue Peganum harmala Bull thistle Cirsium vulgare Chicory Cichorium intybus Halogeton Halogeton glomeratus Malta starthistle Centaurea melitensis Perennial pepperweed Lepidium latifolium Poison hemlock Conium maculatum Quackgrass Elytrigia repens Russian knapweed Acroptilon repens Spiny cocklebur Xanthium spinosum Teasel Dipsacus fullonum Class C Species Class C species are wide-spread in the state. Management decisions for these species should be determined at the local level, based on feasibility of control and level of infestation. Common Name Scientific Name Cheatgrass Bromus tectorum Curlyleaf pondweed Potamogeton crispus Eurasian watermilfoil Myriophyllum spicatum Giant cane Arundo donax Hydrilla Hydrilla verticllata Jointed goatgrass Aegilops cylindrica Musk thistle Carduus nutans Parrotfeather Myriophyllum aquaticum Russian olive Elaeagnus angustifolia Saltcedar Tamarix spp.
    [Show full text]