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Molecular Identification of Commercialized Medicinal Plants in Southern Morocco
Molecular Identification of Commercialized Medicinal Plants in Southern Morocco Anneleen Kool1*., Hugo J. de Boer1.,A˚ sa Kru¨ ger2, Anders Rydberg1, Abdelaziz Abbad3, Lars Bjo¨ rk1, Gary Martin4 1 Department of Systematic Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden, 2 Department of Botany, Stockholm University, Stockholm, Sweden, 3 Laboratory of Biotechnology, Protection and Valorisation of Plant Resources, Faculty of Science Semlalia, Cadi Ayyad University, Marrakech, Morocco, 4 Global Diversity Foundation, Dar Ylane, Marrakech, Morocco Abstract Background: Medicinal plant trade is important for local livelihoods. However, many medicinal plants are difficult to identify when they are sold as roots, powders or bark. DNA barcoding involves using a short, agreed-upon region of a genome as a unique identifier for species– ideally, as a global standard. Research Question: What is the functionality, efficacy and accuracy of the use of barcoding for identifying root material, using medicinal plant roots sold by herbalists in Marrakech, Morocco, as a test dataset. Methodology: In total, 111 root samples were sequenced for four proposed barcode regions rpoC1, psbA-trnH, matK and ITS. Sequences were searched against a tailored reference database of Moroccan medicinal plants and their closest relatives using BLAST and Blastclust, and through inference of RAxML phylograms of the aligned market and reference samples. Principal Findings: Sequencing success was high for rpoC1, psbA-trnH, and ITS, but low for matK. Searches using rpoC1 alone resulted in a number of ambiguous identifications, indicating insufficient DNA variation for accurate species-level identification. Combining rpoC1, psbA-trnH and ITS allowed the majority of the market samples to be identified to genus level. -
Long-Lasting Analgesic Effect of the Psychedelic Drug Changa: a Case Report
CASE REPORT Journal of Psychedelic Studies 3(1), pp. 7–13 (2019) DOI: 10.1556/2054.2019.001 First published online February 12, 2019 Long-lasting analgesic effect of the psychedelic drug changa: A case report GENÍS ONA1* and SEBASTIÁN TRONCOSO2 1Department of Anthropology, Philosophy and Social Work, Universitat Rovira i Virgili, Tarragona, Spain 2Independent Researcher (Received: August 23, 2018; accepted: January 8, 2019) Background and aims: Pain is the most prevalent symptom of a health condition, and it is inappropriately treated in many cases. Here, we present a case report in which we observe a long-lasting analgesic effect produced by changa,a psychedelic drug that contains the psychoactive N,N-dimethyltryptamine and ground seeds of Peganum harmala, which are rich in β-carbolines. Methods: We describe the case and offer a brief review of supportive findings. Results: A long-lasting analgesic effect after the use of changa was reported. Possible analgesic mechanisms are discussed. We suggest that both pharmacological and non-pharmacological factors could be involved. Conclusion: These findings offer preliminary evidence of the analgesic effect of changa, but due to its complex pharmacological actions, involving many neurotransmitter systems, further research is needed in order to establish the specific mechanisms at work. Keywords: analgesic, pain, psychedelic, psychoactive, DMT, β-carboline alkaloids INTRODUCTION effects of ayahuasca usually last between 3 and 5 hr (McKenna & Riba, 2015), but the effects of smoked changa – The treatment of pain is one of the most significant chal- last about 15 30 min (Ott, 1994). lenges in the history of medicine. At present, there are still many challenges that hamper pain’s appropriate treatment, as recently stated by American Pain Society (Gereau et al., CASE DESCRIPTION 2014). -
Alhagi Maurorum
Prepared By Jacob Higgs and Tim Higgs Class 1A EDRR- Early Detection Rapid Response Watch List Common crupina Crupina vulgaris African rue Peganum harmala Small bugloss Anchusa arvensis Mediterranean sage Salvia aethiopis Spring millet Milium vernale Syrian beancaper Zygophyllum fabago North Africa grass Ventenata dubia Plumeless thistle Carduus acanthiodes Malta thistle Centaurea melitensis Common Crupina Crupina vulgaris African rue Peganum harmala Small bugloss Anchusa arvensis Mediterranean sage Salvia aethiopis Spring millet Milium vernale Syrian beancaper Zygophyllum fabago North Africa grass Ventenata dubia Plumeless thistle Carduus acanthiodes Malta thistle Centaurea melitensis m Class 1B Early Detection Camelthorn Alhagi maurorum Garlic mustard Alliaria petiolata Purple starthistle Cantaurea calcitrapa Goatsrue Galega officinalis African mustard Brassica tournefortii Giant Reed Arundo donax Japanese Knotweed Polygonum cuspidatum Vipers bugloss Echium vulgare Elongated mustard Brassica elongate Common St. Johnswort Hypericum perforatum L. Oxeye daisy Leucanthemum vulgare Cutleaf vipergrass Scorzonera laciniata Camelthorn Alhagi maurorum Garlic mustard Alliaria petiolata Purple starthistle Cantaurea calcitrapa Goatsrue Galega officinalis African mustard Brassica tournefortii Giant Reed Arundo donax Japanese Knotweed Polygonum cuspidatum Vipers bugloss Echium vulgare Elongated mustard Brassica elongate Common St. Johnswort Hypericum perforatum L. Oxeye daisy Leucanthemum vulgare Cutleaf vipergrass Scorzonera laciniata Class 2 Control -
Antimicrobial Activity of Peganum Harmala Fixed Oil.Pdf
ﺑﺴﻢ اﷲ اﻟﺮﺣﻤﻦ اﻟﺮﺣﯿﻢ Sudan University of Science and Technology Faculty of Science Department of Chemistry Antimicrobial Activity of Peganum Harmala Fixed Oil A Dissertation Submitted in Partial Fulfillment of the Requirements of the B.Sc (Hons.) Degree in Chemistry By: Elamein Elsadig Hamad Ismaeel Mergany Elnayer Osman Fathalrahman Mohamed Supervisor: Prof. Mohamed Abdel Karim Mohamed Oct.2016 1-Introduction 1.1-Natural products A natural product is a chemical compound or substance produced by a living organism—that is, found in nature.[2][3] In the broadest sense, natural products include any substance produced by life.[4][5] Natural products can also be prepared by chemical synthesis (both semi- synthesis and total synthesis) and have played a central role in the development of the field of organic chemistry by providing challenging synthetic targets. The term natural product has also been extended for commercial purposes to refer to cosmetics, dietary supplements, and foods produced from natural sources without added artificial ingredients.[6]Within the field of organic chemistry, the definition of natural products is usually restricted to mean purified organic compounds isolated from natural sources that are produced by the pathways of primary or secondary metabolism.[7] Within the field of medicinal chemistry, the definition is often further restricted to secondary metabolites.[8][9] Secondary metabolites are not essential for survival, but nevertheless provide organisms that produce them an evolutionary advantage.[10] Many secondary metabolites are cytotoxic and have been selected and optimized through evolution for use as 1 "chemical warfare" agents against prey, predators, and competing organisms.[11] Natural products sometimes have pharmacological or biological activity that can be of therapeutic benefit in treating diseases. -
Switch to Mania After Ayahuasca Consumption in a Man with Bipolar Disorder: a Case Report Alejandro G Szmulewicz1,2*, Marina P Valerio1 and Jose M Smith1
Szmulewicz et al. International Journal of Bipolar Disorders (2015) 3:4 DOI 10.1186/s40345-014-0020-y CASE REPORT Open Access Switch to mania after ayahuasca consumption in a man with bipolar disorder: a case report Alejandro G Szmulewicz1,2*, Marina P Valerio1 and Jose M Smith1 Abstract Background: There is an increasing use of ayahuasca for recreational purposes. Furthermore, there is a growing evidence for the antidepressant properties of its components. However, there are no reports on the effects of this substance in the psychiatric setting. Harmaline, one of the main components of ayahuasca, is a selective and reversible MAO-A inhibitor and a serotonin reuptake inhibitor. Case report: We present the case of a man with bipolar disorder who had a manic episode after an ayahuasca consumption ritual. This patient had had at least one hypomanic episode in the past and is currently depressed. We discuss the diagnostic repercussion of this manic episode. Conclusion: There is lack of specificity in the diagnosis of substance-induced mental disorder. The knowledge of the pharmacodynamic properties of ayahuasca consumption allows a more physiopathological approach to the diagnosis of the patient. Keywords: Ayahuasca; Bipolar disorder; DSM 5; Switch to mania; MAO inhibitors Background oral biodisponibility increases, this interaction being the Ayahuasca is a psychotropic, hallucinogenic beverage, base of ayahuasca psychotropic effect (McKenna 2004). composed of a mixture of Amazonian plants. It is usu- ally consumed as an infusion with Banisteriopsis caapi Case presentation Psychotria viridis and (Guimaraes dos Santos 2010). The We present the case of a 30-year-old Argentinian man, B. -
Experimental and Cytological Studies on Plant Species
Biologiske Skrifter udgivet af Det Kongelige Danske Videnskabernes Selskab Bind 11, nr. 6 Biol. Skr. Dan. Vid. Selsk. 11, no. 6 (1963) EXPERIMENTAL AND CYTOLOGICAL STUDIES ON PLANT SPECIES VIII. RACIAL DIFFERENTIATION IN AMPHI-ATLANTIC VISCARIA ALPINA BY TYGE W. BOCHER København 1963 i kommission hos Ejnar Munksgaard Det Kongelige Danske Videnskabernes Selskab udgiver følgende pub likationsrækker : The Royal Danish Academy of Sciences and Letters issues the fol lowing series of publications: Bibliographical Abbreviation Oversigt over Selskabets Virksomhed (8°) Overs. Dan. Vid. Selsk. (Annual in Danish) Historisk-fllosofiske Meddelelser (8°) Hist. Filos. Medd. Dan. Vid. Selsk. Historisk-filosofiske Skrifter (4°) Hist. Filos. Skr. Dan. Vid. Selsk. (History, Philology, Philosophy, Archeology, Art History) Matematisk-fysiske Meddelelser (8°) Mat. Fys. Medd. Dan. Vid. Selsk. Matematisk-fysiske Skrifter (4°) Mat. Fys. Skr. Dan. Vid. Selsk. (Mathematics, Physics, Chemistry, Astronomy, Geology) Biologiske Meddelelser (8°) Biol. Medd. Dan. Vid. Selsk. Biologiske Skrifter (4°) Biol. Skr. Dan. Vid. Selsk. (Botany, Zoology, General Biology) Selskabets sekretariat og postadresse: Dantes Plads 5, København V. The address of the secretariate of the Academy is: Det Kongelige Danske Videnskabernes Selskab, Dantes Plads 5, Kbbenhavn V, Denmark. Selskabets kommissionær: E jn a r Mu n k sg a a r d ’s Forlag, Nørregade 6, København K. The publications are sold by the agent of the Academy: E jn a r Mu n k sg a a r d , Publishers, 6 Norregade, Kbbenhavn K, Denmark. BIOLOGISKE SKRIFTER UDGIVET AF DET KGL. DANSKE VIDENSKABERNES SELSKAB BIND 11 KØBENHAVN I KOMMISSION HOS EJNAR MUNKSGAARD 1959-63 INDHOLD Side 1. Foged, Niels: Diatoms from Afghanistan. -
Lali Kintsurashvili
Lali Kintsurashvili Personal information Contact Details ID Number: 01024041567 Email address: [email protected] Full name: Lali Kintsurashvili Call number: 599407944 Gender: Female Country: საქართველო (Georgia) Date of birth: 04.09.1958 City: Tbilisi Citizenship: საქართველო (Georgia) Address: Tbilisi 0159, P. Sarajishvili 36 st. Languages Language Writing Reading Speaking French A1 A2 A1 Latin B1 B1 A2 Russian C2 C1 C2 English B1 B1 B1 ქართული (Georgian) C2 C2 C2 Education Academic degree Academic Degree: Doctoral/PhD, Ed.D or other equivalent Year obtained: 24.12.1997 Education Start End Academic Degree Name of the Institution Country Major discipline year year Doctoral/PhD, Ed.D or Institute of Pharmacochemistry Georgian საქართველო Pharmacy: Pharmaceutical chemistry 1982 1986 other equivalent Academy of Sciences (postgraduate studies) (Georgia) and Pharmakognosy, restr. 15.00.02 Master/MS, MA, MR, MBA, m.Ed or other Tbilisi State Medical Institute საქართველო Pharmacy 1976 1981 equivalent (Georgia) Projects Completed projects Project Start Project title Position head Date End Date Donor N 843/07 In Georrgian National Scientific fund financed by the cjmpetition GNSF/ ST06/6-102" Blood formation organ function assistant Inga Iovel Kutateladze sttimulatory vegetable containing of alkaloid new drug form shapes performerdadeshidze10.04.200625.12.2008 institute of of foundation biodegradable Pharmakochhhhhhemistry Scientific Fields Main Field Field: 3. Medical and health sciences Sub-Field: 3.1 Basic medicine Subject area: 3.1.5 Pharmacology and pharmacy Employment History Current place(s) of employment Name of the Workplace work Position Main responsibilities Start department Date Tbilisi State Department of The study of Georgian flora on alkaloids composition and detection of Medical university Phytochemistry, senior biologically and pharmcologically active substances. -
Alien Flora of Europe: Species Diversity, Temporal Trends, Geographical Patterns and Research Needs
Preslia 80: 101–149, 2008 101 Alien flora of Europe: species diversity, temporal trends, geographical patterns and research needs Zavlečená flóra Evropy: druhová diverzita, časové trendy, zákonitosti geografického rozšíření a oblasti budoucího výzkumu Philip W. L a m b d o n1,2#, Petr P y š e k3,4*, Corina B a s n o u5, Martin H e j d a3,4, Margari- taArianoutsou6, Franz E s s l7, Vojtěch J a r o š í k4,3, Jan P e r g l3, Marten W i n t e r8, Paulina A n a s t a s i u9, Pavlos A n d r i opoulos6, Ioannis B a z o s6, Giuseppe Brundu10, Laura C e l e s t i - G r a p o w11, Philippe C h a s s o t12, Pinelopi D e l i p e t - rou13, Melanie J o s e f s s o n14, Salit K a r k15, Stefan K l o t z8, Yannis K o k k o r i s6, Ingolf K ü h n8, Hélia M a r c h a n t e16, Irena P e r g l o v á3, Joan P i n o5, Montserrat Vilà17, Andreas Z i k o s6, David R o y1 & Philip E. H u l m e18 1Centre for Ecology and Hydrology, Hill of Brathens, Banchory, Aberdeenshire AB31 4BW, Scotland, e-mail; [email protected], [email protected]; 2Kew Herbarium, Royal Botanic Gardens Kew, Richmond, Surrey, TW9 3AB, United Kingdom; 3Institute of Bot- any, Academy of Sciences of the Czech Republic, CZ-252 43 Průhonice, Czech Republic, e-mail: [email protected], [email protected], [email protected], [email protected]; 4Department of Ecology, Faculty of Science, Charles University, Viničná 7, CZ-128 01 Praha 2, Czech Republic; e-mail: [email protected]; 5Center for Ecological Research and Forestry Applications, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain, e-mail: [email protected], [email protected]; 6University of Athens, Faculty of Biology, Department of Ecology & Systematics, 15784 Athens, Greece, e-mail: [email protected], [email protected], [email protected], [email protected], [email protected]; 7Federal Environment Agency, Department of Nature Conservation, Spittelauer Lände 5, 1090 Vienna, Austria, e-mail: [email protected]; 8Helmholtz Centre for Environmental Research – UFZ, Department of Community Ecology, Theodor-Lieser- Str. -
African Rue Peganum Harmala
African rue Other common names: wild rue, rue weed, USDA symbol: PEHA Peganum harmala and Syrian rue ODA rating: A and T Introduction: African rue is native to the deserts of Africa and southern Asia. There are known sites in New Mexico, Arizona, Texas, California, Oregon and Washington. Introduced from the Mediterranean region and Middle East. The plant was first recognized in the United States in 1920 near Deming, New Mexico and has naturalized in parts of southwestern United States including Arizona, New Mexico, and parts of west Texas. Dehulled seeds yield edible oil similar to cottonseed oil. Plants have been used medicinally and produce red dye in the Middle East. Distribution in Oregon: The first documented site in Oregon was 1967 in Crook County. In 2008, African rue was identified in Harney County. For a collection of spatial information on the distribution of this plant in Oregon, go to Oregon WeedMapper Description: African rue is a multi-branched and bushy perennial. A member of the Caltrop family, it is a succulent plant, with bright green alternating leaves that are smooth and finely divided with long, narrow segments. Plants grow 1.5 feet tall and 3-4 feet in diameter. Flowers are white with five individual petals and are present in spring to early fall. Fruit is located in a leathery capsule 2-4 celled that contains 45-60 seeds. Seeds are angular, dark brown and have a distinctive smell. When crushed, the stems also have a disagreeable odor. The base of this plant is woody and roots can branch and reach 20 feet in depth. -
Chemistry, Pharmacology and Medicinal Properties of Peganum Harmala L
African Journal of Pharmacy and Pharmacology Vol. 6(22), pp. 1573-1580, 15 June, 2012 Available online at http://www.academicjournals.org/AJPP DOI: 10.5897/AJPP11.876 ISSN 1996-0816 ©2012 Academic Journals Review Chemistry, pharmacology and medicinal properties of Peganum harmala L. Jinous Asgarpanah and Fereshteh Ramezanloo Department of Pharmacognosy, Pharmaceutical Sciences Branch, Islamic Azad University (IAU), Tehran, Iran. Accepted 16 March, 2012 Peganum harmala L. is known as Syrian rue, Wild rue and Harmal. P. harmala extracts are considered important for drug development, because they are reported to have numerous pharmacological activities in the Middle East, especially in Iran and Egypt. For a long time P. harmala has been used in traditional medicines for the relief of pain and as an antiseptic agent. P. harmala also have antibacterial, antifungal, antiviral, antioxidant, antidiabetic, antitumor, antileishmanial, insecticidal and cytotoxic activities and hepatoprotective and antinociceptive effects. Harmaline, harmine, harmalol, harman, quinazoline derivatives, vasicine, vasicinone, anthroquinons and fixed oils are reported from seeds and roots of this plant. This plant is used as a medicine in Turkey, Syria, Iran, Pakistan, India, Egypt and Spain. This article presents comprehensive analyzed information on the botanical, chemical and pharmacological aspects of P. harmala. Key words: Peganum harmala, Zygophyllaceae, phytochemical, pharmacological properties. INTRODUCTION Peganum harmala commonly known as Syrian rue and many-branched stems may have a spread of four feet or Wild rue is a flowering plant and is widely distributed in more, the plant is rarely over two feet tall and generally the Central Asia, North Africa and Middle East. It has also appears round and bushy in habit. -
Phytochemical Screening, Total Phenolics and Biological Activities of Tunisian Peganum Harmala Seed Extracts
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2017, 9(2):32-39 ISSN : 0975-7384 Research Article CODEN(USA) : JCPRC5 Phytochemical Screening, Total Phenolics and Biological Activities of Tunisian Peganum harmala Seed Extracts Maroua Khadhr1,2*, Dalila Bousta2, Hanane El Hajaji3, Mohammed Lachkar3, Hassan Barkai4, Saad Ibnsouda-Koraichi4 and Sadok Boukhchina1 1Biochemistry of Lipids and proteins Unit, Department of Biology, Faculty of Sciences of Tunis El Manar II 2092, Tunisia 2Laboratory of Pharmaco-Toxicology, National Agency of Medicinal and Aromatic Plants, Morocco 3Engineering of Organometallic and Molecular Materials Laboratory, Faculty of Sciences, University Sidi Mohamed Ben Abdellah, Morocco 4Laboratory of Microbial Biotechnology, Faculty of Science and Technology, Morocco _____________________________________________________________________________ ABSTRACT Peganum harmala, belonging to Zygophyllaceae family, is a herb with medicinal properties. This study evaluates the antioxidant activity of Tunisian Peganum harmala seed extracts obtained by two methods of extraction. The antimicrobial activity was also evaluated. The antioxidant activity of the extracts of Peganum harmala was studied by three different methods, including scavenging activity by DPPH, phosphomolybdenum method and reducing power of iron. The antimicrobial activity was evaluated using the broth microdilution assay. Results show that extract concentration was directly proportional to the antioxidant activity and the extracts of the maceration extraction showed a higher antioxidant activity than that in extracts of the soxhlet extraction. At all concentrations compared with BHT, the hexane extract have a higher antioxidant activity than those of all extracts of Peganum harmala seeds. For the phosphomolybdenum method, all the extracts showed an increase in antioxidant capacity with an increase in dose. -
New Taxa of Sorbus from Bohemia (Czech Republic)
Verh.© Zool.-Bot. Zool.-Bot. Ges. Österreich, Ges. Austria;Österreich download 133 unter www.biologiezentrum.at(1996): 319-345 New taxa of Sorbus from Bohemia (Czech Republic) M iloslav Ko v a n da Three species of Sorbus are described as new: S. rhodanthera (one Station in W Bohemia) and S. gemella (one Station in W Central Bohemia) belonging to the S. latifolia agg. and S. quernea (two stations in Central Bohemia) of the S. hybrida agg. Basic data on their karyology, morphology, Variation, relation- ships, geographical distribution, ecology and ecobiology are provided. Also described is one primary hybrid, S. X abscondita (S. aucuparia L. X S. danu- bialis [JÄv.] P rodan) o f the S. hybrida agg. Kovanda M., 1996: Neue Sorbus-Taxa aus Böhmen (Tschechische Republik). Drei Sorbus- Arten werden als neu beschrieben: S. rhodanthera (ein Fundort in W-Böhmen) und S. gemella (ein Fundort in W-Mittelböhmen) der S. latifolia agg. und S. quernea (zwei Fundorte in Mittelböhmen) der S. hybrida agg. Grundlegende Daten zur Karyologie, Morphologie, Variation, Verwandtschaft, geographischen Verbreitung, Ökologie, Phytozönologie und Ökobiologie werden präsentiert. Weiters wird eine Primärhybride, S. X abscondita (S. aucuparia L. X S. danubialis [JÄv.] Prodan) der 5. hybrida agg. beschrieben. Keywords: Sorbus, Bohemia, chromosome numbers, morphological Variation, geographical distribution, ecology, phytocenology, ecobiology, interspecific hybridization. Introduction Interspecific hybridization with concomitant polyploidy and apomixis is an acknowledged vehicle of speciation in Sorbus (e.g. Liu efo r s 1953, 1955, Ko v a n d a 1961, Challice & Ko v a n d a 1978, Ja nk un & Ko v a n da 1986, 1987, 1988, Kutzelnigg 1994).