Demystifying Psilocybin - a Science-Based Framework for Understanding Its Actions
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514 1. ABSTRACT 2. INTRODUCTION Role of Platelet Serotonin in Innate
[Frontiers In Bioscience, Landmark, 24, 514-526, Jan 1, 2019] Role of platelet serotonin in innate immune cell recruitment Claudia Schoenichen1, Christoph Bode1, Daniel Duerschmied1 1Department of Cardiology and Angiology I, Faculty of Medicine, Heart Center, University of Freiburg. Breisacher Str. 33, 79106 Freiburg TABLE OF CONTENTS 1. Abstract 2. Introduction 3. Serotonin and the innate immune system: immune cell recruitment 3.1. Platelets release and respond to serotonin 3.2. Monocytes and macrophages respond to 5-HT in a complex manner 3.3. Serotonin acts as a chemoattractant on dendritic cells 3.4. Serotonin promotes neutrophil recruitment in acute inflammation 3.5. Eosinophil trafficking is enhanced by serotonin 3.6. Basophils/Mast Cells 4. Serotonin and the recruitment of adaptive immune cells 4.1. T lymphocytes 4.2. B lymphocytes 4.3. NK Cells 5. Serotonin on endothelial and smooth muscle cells 6. Conclusion 1. ABSTRACT Serotonin (5-Hydroxytryptamine, 5-HT) was understand the effect of serotonin on immune cell discovered as a vasoconstrictor in 1937. Since its recruitment to sites of inflammation. discovery, the involvement of serotonin in numerous physiological processes was described. It acts as 2. INTRODUCTION an important neurotransmitter, regulates bowel movement, can be released as a tissue hormone Serotonin, 5-Hydroxytryptamine (5-HT), and acts as a growth factor. Among the years, was first discovered by Vittorio Erspamer in 1937. a link between serotonin and inflammation has The Italian pharmacologist extracted an unknown been identified and further evidence suggests an bioactive substance from enterochromaffin gut important role of serotonergic components in immune cells, which showed vasoconstrictive features when responses. -
Microdosing Psychedelics: Results from the Global Drug Survey 2019
Microdosing Psychedelics: Results from the Global Drug Survey 2019 Petranker, R.1,2, Anderson, T.2,3, Maier, L. J.4,5, Barratt, M. J.6,7, Ferris, J. A.8, & Winstock, A. R.9,10 1 Clinical Psychology, York University, Toronto, ON, Canada 2 Psychedelic Studies Research Program, University of Toronto Mississauga, Mississauga, ON, Canada 3 Department of Psychology, University of Toronto, Toronto, ON, Canada. 4 Department of Psychiatry and Weill Institute for Neurosciences, University of California, San Francisco, CA, United States 5 Early Postdoc Mobility Grantee, Swiss National Science Foundation, Bern, Switzerland 6 Social and Global Studies Centre, RMIT University, Australia 7 National Drug and Alcohol Research Centre, UNSW Sydney, Australia 8 Centre for Health Services Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia 9 University College London, Gower St, Bloomsbury, London, UK 10 Global Drug Survey Ltd, London, UK *Corresponding Author Rotem Petranker Toronto, ON, Canada Email: [email protected] Abstract Microdosing psychedelics – the practice of taking small, sub-hallucinogenic amounts of substances like psilocybin-containing mushrooms or LSD – is becoming increasingly popular. Despite its surging popularity, little is known about the effects of this practice. This research had two aims. First, we attempted to replicate previous findings in the literature regarding the subjective benefits and challenges involved in microdosing. Second, we wanted to examine whether people who microdose test their substances for purity before consumption, and whether approach-intention to microdosing was predictive of more reported benefits. 7,313 people who reported microdosing, from a variety of countries, ages, and other demographics participated in our survey. -
Would D(+)Adrenaline Have a Therapeutic Effect in Depression
Canadian Open Pharmaceutical, Biological and Chemical Sciences Journal Vol. 1, No. 1, July 2016, pp. 1-6 Available online at http://crpub.com/Journals.php Open Access Research article WOULD D(+)ADRENALINE HAVE A THERAPEUTIC EFFECT IN DEPRESSION José Paulo de Oliveira Filho Projeto Phoenix Avenida Duque de Caxias 1456, 66087-310, Belém, PA [email protected] Mauro Sérgio DorsaCattani Instituto de Física da Universidade de São Paulo C. P. 66318, 05315-970, São Paulo, SP [email protected] José Maria FilardoBassalo Academia Paraense de Ciências Avenida Serzedelo Correa 347/1601,66035-400, Belém, PA [email protected] Nelson Pinheiro Coelho de Souza Escola de Aplicação da UFPA – Belém, PA [email protected] This work is licensed under a Creative Commons Attribution 4.0 International License. _____________________________________________ Abstract In this article, we will analyze a possible therapeutic effect that the enantiomer D (+) of the epinephrine molecule (C9H13NO3) produces in a person who is in a state of depressive anxiety. After presenting a brief historical overview of the depression problem, the discovery of neurotransmitters, the role of enantiomers and the treatment by antidepressants. Just like Citalopram (C20H21N2FO) (Escitalopram), whose antidepressant effect is restricted only to its positive enantiomer [S (+)], we conjecture the existence of an antidepressant effect due to adrenaline also restricted to its positive enantiomer [D (+)].However, up to the moment the production of theD(+)– adrenaline in human body has not been detected yet. We conjecture that the presence of this enantiomer in human body is likely to be detected in blood tests done immediately after parachute jumps. We propose that the D(+) Adrenalineproduction during parachute jumps be caused by the violent emotional shock due to the confrontation with death and that this production happens through the following processes: (a) Almost all L (-) adrenaline becomes D (+) adrenaline through anultra-fast racemization (b) the body itself begins to produce a D(+) adrenaline at large amount. -
Peptide Chemistry up to Its Present State
Appendix In this Appendix biographical sketches are compiled of many scientists who have made notable contributions to the development of peptide chemistry up to its present state. We have tried to consider names mainly connected with important events during the earlier periods of peptide history, but could not include all authors mentioned in the text of this book. This is particularly true for the more recent decades when the number of peptide chemists and biologists increased to such an extent that their enumeration would have gone beyond the scope of this Appendix. 250 Appendix Plate 8. Emil Abderhalden (1877-1950), Photo Plate 9. S. Akabori Leopoldina, Halle J Plate 10. Ernst Bayer Plate 11. Karel Blaha (1926-1988) Appendix 251 Plate 12. Max Brenner Plate 13. Hans Brockmann (1903-1988) Plate 14. Victor Bruckner (1900- 1980) Plate 15. Pehr V. Edman (1916- 1977) 252 Appendix Plate 16. Lyman C. Craig (1906-1974) Plate 17. Vittorio Erspamer Plate 18. Joseph S. Fruton, Biochemist and Historian Appendix 253 Plate 19. Rolf Geiger (1923-1988) Plate 20. Wolfgang Konig Plate 21. Dorothy Hodgkins Plate. 22. Franz Hofmeister (1850-1922), (Fischer, biograph. Lexikon) 254 Appendix Plate 23. The picture shows the late Professor 1.E. Jorpes (r.j and Professor V. Mutt during their favorite pastime in the archipelago on the Baltic near Stockholm Plate 24. Ephraim Katchalski (Katzir) Plate 25. Abraham Patchornik Appendix 255 Plate 26. P.G. Katsoyannis Plate 27. George W. Kenner (1922-1978) Plate 28. Edger Lederer (1908- 1988) Plate 29. Hennann Leuchs (1879-1945) 256 Appendix Plate 30. Choh Hao Li (1913-1987) Plate 31. -
Classification of Single Normal and Alzheimer's Disease Individuals
ORIGINAL RESEARCH published: 23 February 2016 doi: 10.3389/fnins.2016.00047 Classification of Single Normal and Alzheimer’s Disease Individuals from Cortical Sources of Resting State EEG Rhythms Claudio Babiloni 1, 2*, Antonio I. Triggiani 3, Roberta Lizio 1, 2, Susanna Cordone 1, Giacomo Tattoli 4, Vitoantonio Bevilacqua 4, Andrea Soricelli 5, 6, Raffaele Ferri 7, Flavio Nobili 8, Loreto Gesualdo 9, José C. Millán-Calenti 10, Ana Buján 10, Rosanna Tortelli 11, Valentina Cardinali 11, 12, Maria Rosaria Barulli 13, Antonio Giannini 14, Pantaleo Spagnolo 15, Silvia Armenise 16, Grazia Buenza 11, Gaetano Scianatico 13, Giancarlo Logroscino 13, 16, Giovanni B. Frisoni 17, 18 and Claudio del Percio 5 1 Department of Physiology and Pharmacology “Vittorio Erspamer”, University of Rome “La Sapienza”, Rome, Italy, 2 Department of Neuroscience, IRCCS San Raffaele Pisana, Rome, Italy, 3 Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy, 4 Department of Electrical and Information Engineering, Polytechnic of Bari, Bari, Italy, 5 Department of Integrated Imaging, IRCCS SDN - Istituto di Ricerca Diagnostica e Nucleare, Napoli, Italy, 6 Department of Edited by: Motor Sciences and Healthiness, University of Naples Parthenope, Naples, Italy, 7 Department of Neurology, IRCCS Oasi Fernando Maestú, Institute for Research on Mental Retardation and Brain Aging, Troina, Italy, 8 Service of Clinical Neurophysiology (DiNOGMI; Complutense University, Spain DipTeC), IRCCS Azienda Ospedaliera Universitaria San Martino - IST, Genoa, Italy, 9 Dipartimento Emergenza e Trapianti d’Organi, University of Bari, Bari, Italy, 10 Gerontology Research Group, Department of Medicine, Faculty of Health Sciences, Reviewed by: University of A Coruña, A Coruña, Spain, 11 Department of Clinical Research in Neurology, University of Bari “Aldo Moro”, Pia José A. -
Community and Practice in Two Generations of Online Illicit Drugs Discussions
Community and practice in two generations of online illicit drugs discussions A thesis submitted to the University of Manchester for the degree of Doctor of Philosophy in the Faculty of Humanities. 2020 P. O. Enghoff School of Social Sciences, Department of Criminology and Criminal Justice Table of Contents Abstract .................................................................................................................. 5 Acknowledgements .............................................................................................. 8 Other acknowledgements .................................................................................... 9 The author .............................................................................................................. 9 Chapter 1. Introduction ..................................................................................... 10 1.1 Background ........................................................................................... 11 1.2 Summary of thesis contents ................................................................ 19 1.2.1 Literature review .......................................................................... 20 1.2.2 Research design ............................................................................. 24 1.2.3 Research papers ............................................................................ 28 1.2.4 Discussion ...................................................................................... 31 Chapter 2. Literature review ............................................................................ -
(PROK2) in Alzheimer's Disease
cells Communication Involvement of the Chemokine Prokineticin-2 (PROK2) in Alzheimer’s Disease: From Animal Models to the Human Pathology Roberta Lattanzi 1, Daniela Maftei 1, Carla Petrella 2, Massimo Pieri 3, Giulia Sancesario 4, Tommaso Schirinzi 5, Sergio Bernardini 3, Christian Barbato 2 , Massimo Ralli 6 , Antonio Greco 6, Roberta Possenti 5, Giuseppe Sancesario 5 and Cinzia Severini 2,* 1 Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, P.za A. Moro 5, 00185 Rome, Italy; [email protected] (R.L.); [email protected] (D.M.) 2 Institute of Biochemistry and Cell Biology, IBBC, CNR, Viale del Policlinico, 155, 00161 Rome, Italy; [email protected] (C.P.); [email protected] (C.B.) 3 Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, 00133 Rome, Italy; [email protected] (M.P.); [email protected] (S.B.) 4 Neuroimmunology Unit, IRCCS Santa Lucia Foundation, v. Ardeatina 354, 00179 Rome, Italy; [email protected] 5 Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy; [email protected] (T.S.); [email protected] (R.P.); [email protected] (G.S.) 6 Department of Sense Organs, University Sapienza of Rome, Viale del Policlinico 155, 00161 Rome, Italy; [email protected] (M.R.); [email protected] (A.G.) * Correspondence: [email protected]; Tel.: +39-06-4997-6742 Received: 17 October 2019; Accepted: 12 November 2019; Published: 13 November 2019 Abstract: Among mediators of inflammation, chemokines play a pivotal role in the neuroinflammatory process related to Alzheimer’s disease (AD). -
Editorial Oxidative Stress As a Pharmacological Target for Medicinal Chemistry: Synthesis and Evaluation of Compounds with Redox Activity - Part 3
414 Current Topics in Medicinal Chemistry, 2015, Vol. 15, No. 5 Editorial Editorial Oxidative Stress as a Pharmacological Target for Medicinal Chemistry: Synthesis and Evaluation of Compounds with Redox Activity - Part 3 Over the last years it has been recognized that a diversity of exogenous and endogenous sources can induce oxidative stress and that free radicals overproduction can cause oxida- tive damage to biomolecules. These events have been linked to several diseases, such as atherosclerosis and other cardiovascular dysfunctions, cancer, diabetics, rheumatoid arthri- tis, chronic inflammation, stroke, aging and neurodegenerative disorders. In oxidative-stress related diseases the endogenous antioxidant defenses have been found to be insufficient to prevent the oxidative damage and as consequence different efforts are currently be under- taken to increase the levels of antioxidants as they can minimize the injury caused by oxida- tive stress. Therefore, the increment of the pool of endogenous antioxidants or the intake of exogenous antioxidants can be an effective therapeutic solution. In this special issue the progresses towards the understanding of the mechanisms of oxi- dative damage and of natural or synthetic antioxidants (lipoic acid and a diversity of pheno- lic systems, namely those based on coumarin and chromone scaffolds) and their interaction with the redox-sensitive signaling pathways involved in the pathophysiology of oxidative- stress related diseases (cancer and neurodegenerative events) are reported. Furthermore the -
BC2019-Printproginccovers-High.Pdf
CONTENTS Welcome with Acknowledgements 1 Talk Abstracts (Alphabetically by Presenter) 3 Programme (Friday) 32–36 Programme (Saturday) 37–41 Programme (Sunday) 42–46 Installations 47–52 Film Festival 53–59 Entertainment 67–68 Workshops 69–77 Visionary Art 78 Invited Speaker & Committee Biographies 79–91 University Map 93 Area Map 94 King William Court – Ground Floor Map 95 King William Court – Third Floor Map 96 Dreadnought Building Map (Telesterion, Underworld, Etc.) 97 The Team 99 Safer Spaces Policy 101 General Information 107 BREAK TIMES - ALL DAYS 11:00 – 11:30 Break 13:00 – 14:30 Lunch 16:30 – 17:00 Break WELCOME & ACKNOWLEDGEMENTS WELCOME & ACKNOWLEDGEMENTS for curating the visionary art exhibition, you bring that extra special element to BC. Ashleigh Murphy-Beiner & Ali Beiner for your hard work, in your already busy lives, as our sponsorship team, which gives us more financial freedom to put on such a unique event. Paul Callahan for curating the Psychedelic Cinema, a fantastic line up this year, and thanks to Sam Oliver for stepping in last minute to help with this, great work! Andy Millns for stepping up in programming our installations, thank you! Darren Springer for your contribution to the academic programme, your perspective always brings new light. Andy Roberts for your help with merchandising, and your enlightening presence. Julian Vayne, another enlightening and uplifting presence, thank you for your contribution! To Rob Dickins for producing the 8 circuit booklet for the welcome packs, and organising the book stall, your expertise is always valuable. To Maria Papaspyrou for bringing the sacred feminine and TRIPPth. -
Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanismss
Supplemental Material can be found at: /content/suppl/2020/12/18/73.1.202.DC1.html 1521-0081/73/1/202–277$35.00 https://doi.org/10.1124/pharmrev.120.000056 PHARMACOLOGICAL REVIEWS Pharmacol Rev 73:202–277, January 2021 Copyright © 2020 by The Author(s) This is an open access article distributed under the CC BY-NC Attribution 4.0 International license. ASSOCIATE EDITOR: MICHAEL NADER Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanismss Antonio Inserra, Danilo De Gregorio, and Gabriella Gobbi Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, Montreal, Quebec, Canada Abstract ...................................................................................205 Significance Statement. ..................................................................205 I. Introduction . ..............................................................................205 A. Review Outline ........................................................................205 B. Psychiatric Disorders and the Need for Novel Pharmacotherapies .......................206 C. Psychedelic Compounds as Novel Therapeutics in Psychiatry: Overview and Comparison with Current Available Treatments . .....................................206 D. Classical or Serotonergic Psychedelics versus Nonclassical Psychedelics: Definition ......208 Downloaded from E. Dissociative Anesthetics................................................................209 F. Empathogens-Entactogens . ............................................................209 -
Dosing Creativity
UvA-DARE (Digital Academic Repository) Drug-craft On the configurations of psychedelic efficacies Mishra, S. Publication date 2020 Document Version Other version License Other Link to publication Citation for published version (APA): Mishra, S. (2020). Drug-craft: On the configurations of psychedelic efficacies. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl) Download date:06 Oct 2021 Chapter 1 Dosing Creativity Besides alcohol, I don’t really use drugs and have little interest in them, but this microdosing – for work, being creative, for being focused and effective… its increased use by Silicon Valley professionals – it did catch my attention. You research drugs, what do you think about it? I would like to try it someday. (Informal conversation, Amsterdam 2017) This is what Jan said to me, on an afternoon at my research institute in Amsterdam, as we bumped into each other by the department’s coffee machine. -
Occurrence of Indolealkylamines in Nature by VITTORIO ERSPAMER with One Figure I
Chapter 4 Occurrence of indolealkylamines in nature By VITTORIO ERSPAMER With one Figure I. Introduction Quantitative data on the occurrence of 5-HT and related indolealkylamines in nature are presented in Tables 1-23 of this chapter and in Tables 1-6 of chapter 13. The interest of these data is obvious, especially for the interpretation of the physiological significance of indolealkylamines in their different localizations. However, it seems opportune to call attention at once to a few points. The occurrence of 5-HT or another indolealkylamine in a tissue does not of necessity imply that the amine has particular importance in this tissue. In fact, it is obvious that one is authorized to surmise that a given localization of an indole alkylamine has a general biological significance only if this localization occurs in all or in a great number of species. Quantitative data on the concentration of indolealkylamines in a tissue reflect only a static situation, and they give no indication of the rapidity of synthesis and metabolism of the amines. There is no doubt that knowledge of the turnover rate of the amines in a tissue is considerably more important, from every point of view, than knowledge of the content of the amines at a given moment. To give only one example, it is probable that the amount of 5-HT synthetized and destroyed in a 24-hour period in the rat brain is considerably larger than that metabolized in the skin of Bombina variegata pachy'fYUS or Discoglossus pictus. Yet, it will be seen that the first tissue contains as little as 0.4-0.6 f-lg/g 5-HT, the second 200--450 f-lg/g.