Charybdotoxin ChTx - #11CHA001 - CAS : 95751-30-7 Product information

2+ Animal toxins for life-sciences KCa channel blocker www.smartox-biotech.com Charybdotoxin (ChTx) is a 37 amino acid peptide isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus that blocks voltage-gated and large conductance Phone : +33(0) 456 520 869 Ca2+ activated K+ channels K 1.1 in nanomolar concentrations (IC ~ 3 nM). This blockade Fax : +33(0) 456 520 868 Ca 50 [email protected] causes hyperexcitability of the nervous system. The toxin reversibly blocks channel activity by interacting at the external pore of the channel protein with an apparent Kd of Smartox Biotechnology 2.1 nM. ChTX also blocks KCa3.1 (IC50 5 nM), Kv1.2 (IC50 14 nM), Kv1.3 (IC50 2.6 nM) 570 rue de la chimie and Kv1.6 (IC50 2 nM) channels. 38400 Saint Martin d’Hères France

Prices

 50 µg – 80 €  100 µg – 135 € Technical information  500 µg – 390 €  1 mg – 540 €

AA sequence: Pyr-Phe-Thr-Asn-Val-Ser-Cys7-Thr-Thr-Ser-Lys-Glu-Cys13-Trp-Ser-Val-Cys17- 28 33 35 Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys -Met-Asn-Lys-Lys-Cys -Arg-Cys -Tyr-Ser- Related products OH

Disulfide bridges: Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35  Apamin - #08APA001 Length (aa): 37 Solubility: water and saline buffer  Maurotoxin - #08MAR001 Formula: C176H277N57O55S7 CAS number: 95751-30-7  Leiurotoxin-1 - # 10LEI001 Molecular Weight: 4295.90 Da Source: Synthetic  Tamapin - # 10TAM001 Appearance: White lyophilized solid Purity rate: > 97 %  Iberiotoxin - # 12IBX001

References

 Gimenez-Gallego G., et al. - Proc. Natl. Acad. Sci.  Goldstein SA., Miller C. - Biophys J. Toxin of the month – free sample program  Goldstein SA., et al. – Neuron. Each month, Smartox Biotechnology offers a sample of a selected toxin for absolutely free. To be informed, visit our website each Ordering information month, subscribe our newsletter or follow us on social networks. Clic HERE Smartox products are available worldwide. To place an order, please contact us by phone or email or find out your local distributor on our website. We accept credit card payment. Range of blockers

Voltage-gated sodium channels Acid-sensing ion channels Voltage-gated calcium channels Chloride channels Potassium channels Nicotinic acetylcholine receptors  Voltage-gated potassium channels Purinergic receptors  Calcium activated potassium channels TRP channels  hERG channel Mechanosensitive ion channels  Inward rectifying potassium channels NMDA receptors

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