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Novitski Prize for Jonathan Hodgkin Search Related Information Share

7/14/2017 Novitski Prize for Jonathan Hodgkin Page - Department of Biochemistry, University of Oxford Department of Biochemistry University of Oxford South Parks Road Oxford OX1 3QU Tel: +44 (0)1865 613200 Fax: +44 (0)1865 613201 Anaphase bridges in fission yeast cells Whitby lab Home For Undergraduate For Graduate Research About the Contact For Staff and Current Applicants Applicants Department Students ABOUT THE DEPARTMENT Novitski Prize for Jonathan Hodgkin Search Professor Jonathan Hodgkin has been awarded the prestigious Edward Novitski prize for » Athena Swan 2017 by the Genetics Society of America, in recognition of his "extraordinary creativity and intellectual ingenuity in solving significant problems in genetics research". » Working in the Department Print this page Jonathan has made many outstanding contributions to » @OxBiochNews Twitter Feed genetics ‐ testament to his remarkable command of Related genetic knowledge and understanding. In addition to » Public Engagement and working out the sex determination pathway in C. Information Outreach elegans by using a combination of forward genetics Hodgkin Lab and epistasis analysis, he has also led the field in » What is Biochemistry? several other areas, including informational suppression, natural variation and host‐pathogen Share This » Vacancies interactions. The prize will be awarded to Jonathan at the 21st C. elegans Conference which will be held June » News Archive Professor Jonathan Hodgkin Like 23 21‐25 at UCLA. › Undergraduate Prize Tweet Announcements 2017 Alison Woollard 24th March 2017 › The final step in bacterial Share lipoprotein maturation › Peter Beaconsfield Prizes for Two of Our Young Researchers › Rita Emberton Charity Wing Walk › Norman Heatley Award for Mark Howarth › Family Fun Day at the Royal Institution › Tony Watts and Peter Judge at the Emirates Foundation › How a group of conserved proteins orchestrate transcription termination in eukaryotes › Biochemistry Department spinout uses biochemical superglue to develop next generation vaccines › Novitski Prize for Jonathan Hodgkin › Biochemistry at 'Back From The Dead' › Wellcome Image Awards 2017 › Understanding cerebral malaria: novel molecular insights into a sticky problem › Alison Woollard on Radio 4's The Life Scientific › Dr Sylvia McLain gives Royal Institution Discourse › Prof. Alison Woollard appointed as Academic Champion for Public Engagement with Research › Molecular dynamics simulations aid functional annotation of ion channel structures › Predicting drug selectivity using computers » News archive 2009 » News archive 2010 http://www.bioch.ox.ac.uk/aspsite/index.asp?pageid=1392 1/2.

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2011 C. elegans Meeting Organizing Committee Co-chairs: Oliver Hobert Columbia University Meera Sundaram University of Pennsylvania Organizing Committee: Raffi Aroian University of California, San Diego Ikue Mori Nagoya University Jean-Louis Bessereau INSERM Benjamin Podbilewicz Technion Israel Institute of Keith Blackwell Harvard Medical School Technology Andrew Chisholm University of California, San Diego Valerie Reinke Yale University Barbara Conradt Dartmouth Medical School Janet Richmond University of Illinois, Chicago Marie Anne Felix CNRS-Institut Jacques Monod Ann Rougvie University of Minnesota David Greenstein University of Minnesota Shai Shaham Rockefeller University Alla Grishok Columbia University Ahna Skop University of Wisconsin, Madison Craig Hunter Harvard University Ralf Sommer Max-Planck Institute for Bill Kelly Emory University Developmental Biology, Tuebingen Ed Kipreos University of Georgia Asako Sugimoto RIKEN, Kobe Todd Lamitina University of Pennsylvania Heidi Tissenbaum University of Massachusetts Chris Li City College of New York Medical School Sponsored by The Genetics Society of America 9650 Rockville Pike, Bethesda, MD 20814-3998 telephone: (301) 634-7300 fax: (301) 634-7079 e-mail: [email protected] Web site: http:/www.genetics-gsa.org Front cover design courtesy of Ahna Skop 1 Table of Contents Schedule of All Events.....................................................................................................................4 Maps University of California, Los Angeles, Campus .....................................................................7
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Caenorhabditis Microbiota: Worm Guts Get Populated Laura C
Clark and Hodgkin BMC Biology (2016) 14:37 DOI 10.1186/s12915-016-0260-7 COMMENTARY Open Access Caenorhabditis microbiota: worm guts get populated Laura C. Clark and Jonathan Hodgkin* Please see related Research article: The native microbiome of the nematode Caenorhabditis elegans: Gateway to a new host-microbiome model, http://dx.doi.org/10.1186/s12915-016-0258-1 effects on the life history of the worm are often profound Abstract [2]. It has been increasingly recognized that the worm Until recently, almost nothing has been known about microbiota is an important consideration in achieving a the natural microbiota of the model nematode naturalistic experimental model in which to study, for Caenorhabditis elegans. Reporting their research in instance, host–pathogen interactions or worm behavior. BMC Biology, Dirksen and colleagues describe the first Dirksen et al [3] present the first step towards under- sequencing effort to characterize the gut microbiota standing understanding the complex interactions of the of environmentally isolated C. elegans and the related natural worm microbiota by reporting a 16S rDNA-based taxa Caenorhabditis briggsae and Caenorhabditis “head count” of the bacterial population present in wild remanei In contrast to the monoxenic, microbiota-free nematode isolates (Fig. 1). Interestingly, it appears that cultures that are studied in hundreds of laboratories, it nematodes isolated from diverse natural environment- appears that natural populations of Caenorhabditis s—and even those that have been maintained for a short harbor distinct microbiotas. time on E. coli following isolation—share a “core” host- defined microbiota. This finding is in agreement with work by Berg et al.
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100 Years of Genetics
Heredity (2019) 123:1–3 https://doi.org/10.1038/s41437-019-0230-2 EDITORIAL 100 years of genetics Alison Woollard1 Received: 27 April 2019 / Accepted: 28 April 2019 © The Genetics Society 2019 The UK Genetics Society was founded on 25 June 1919 and “biometricians”; the Genetical Society was very much a this special issue of Heredity, a journal owned by the society of Mendelians. Remarkably, 16 of the original 87 Society, celebrates a century of genetics from the perspec- members were women—virtually unknown in scientific tives of nine past (and present) presidents. societies at the time. Saunders was a vice president from its The founding of the Genetical Society (as it was then beginning and its 4th president from 1936–1938. Perhaps known) is often attributed to William Bateson, although it the new, and somewhat radical, ideas of “genetics” pre- was actually the brain child of Edith Saunders. The enthu- sented a rare opportunity for women to engage in research siasm of Saunders to set up a genetics association is cited in because the field lacked recognition in universities, and was the anonymous 1916 report “Botany at the British Asso- therefore less attractive to men. 1234567890();,: 1234567890();,: ciation”, Nature, 98, 2456, p. 238. Furthermore, the actual Bateson and Saunders (along with Punnett) were also founding of the Society in 1919 “largely through the energy influential in the field of linkage analysis (“partial coupling” as of Miss E.R Saunders” is reported (anonymously) in they referred to it at the time), having made several observa- “Notes”, Nature, 103, 2596, p.
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Genetic Suppression* §
Genetic suppression* § Jonathan Hodgkin , Genetics Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK Table of Contents 1. Introduction ............................................................................................................................2 2. Intragenic suppression by same site replacement ............................................................................ 2 3. Intragenic suppression by compensatory second site mutation .......................................................... 2 4. Intragenic suppression by altered splicing ..................................................................................... 2 5. Intragenic suppression of dominant mutations by loss-of-function in cis. ............................................2 6. Extragenic suppression — overview ............................................................................................ 3 7. Informational suppression — overview ........................................................................................ 4 8. Nonsense suppression ............................................................................................................... 4 9. Extragenic suppression by modified splicing ................................................................................. 5 10. Suppression by loss of NMD (Nonsense Mediated Decay) ............................................................. 6 11. Extragenic suppression by non-specific physiological effects .........................................................
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Caenorhabditis Elegans
INFORMAnON TO USERS This manuscript has been reprodueed from the microfilm master. UMI films the text directly from the original or copy submitted. Thus, sorne thesis and dissertation copies are in typewriter face. while oIhers may be from any type of computer printer. The quality of thla ntproduction .. dependent upon the q..11ty of the copy submitted. Broken or indisti1ct print, coIored or poor quality illustrations and photographs. print bleedthrough. s~ndard margïns. and improper alignment can adversely affect reproduction. ln the unlikely event that the author did not send UMI a complete manuscript and there are missing pages. these will be noted. Also. if unaulhorized copyright material had to be ntmoved. a note will indicate the defetion. Oversize materials (e.g.• map5. drawings. charts) are reproduced by sectioning the original. begiming al the upper Ieft-hand corner and continuing from Ieft to right in equal sections with small overlaps. Photographs induded in the original rnanuscript have been reproduced xerographically in this copy. Higher quality 6- x 9"' black and white photographie prints are available for any photographs or illustrations appearing in this copy for an additional charge. Contact UMI direclly to ORter. Bell & HoweIllntormation and Leaming 300 Nor1h leeb Road, Ann Arbor, MI 48106-1346 USA e UMI800-521..Q600 • Genetic factors affecting life span in the nematode Caenorhabditis elegans Bernard C. Lakowski, Department ofBiology, McGill University. March 1988 A thesis submitted to the Faculty ofGraduate Studies and Researcb in partial fulf"t1lment ofthe requirements ofthe degree ofPh. D. © Bernard C. Lakowski 1998 • National Ubrary Bibliothèque nationale 1+1 of Canada du Canada Acquisitions and Acquisitions et Bibliographie services services bibliographiques 395 Wellington Street 395.
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Winter/Spring 2020
WINTER/SPRING 2020 EINSTEINTHE MAGAZINE FOR ALUMNI AND FRIENDS OF ALBERT EINSTEIN COLLEGE OF MEDICINE FORGING THE OF Einstein and Montefiore scholars FUTURE meld research with data to improve MEDICINE patient care INSIDE: Mapping a Roundworm’s Nervous System • The Physician Investigators EINSTEIN A Message from the Dean Science at the Heart of Medicine Winter/Spring 2020 The magazine for alumni, faculty, s 2019 came to a close, students, friends, and supporters of we learned that Einstein Albert Einstein College of Medicine and Montefiore researchers had secured $178 million in grants Published by Afrom the National Institutes of Health The Philip and Rita Rosen Department of Communications and Public Affairs (NIH)—our largest annual total ever Gordon Earle, Associate Dean (page 14). The grants included funds Office of Development to study the Ebola virus and HIV, to Rachelle M. Sanders, Vice President and continue research on neuroscience and Chief Development Officer genetics, and to improve health among Director, Science and Research Content minority groups. Larry Katzenstein The year’s end also brought news Senior Director, Strategic Communications and External Relations that Philip O. Ozuah, M.D., Ph.D., Deirdre Branley has become the new chief executive Managing Editor officer of Montefiore Medicine, the Susan Byrne umbrella organization for Montefiore Director, Creative Services Health System and Einstein (page 2). system of the worm C. elegans for the Marie L. Kurtz Dr. Ozuah has decades of experience better part of two decades. The story of Senior Director of External Relations, in leadership positions at Montefiore his success in completing the first wiring Development Rachel Eddey and a strong commitment to research diagram of an animal’s entire nervous and medical education.
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Applications of the Free-Living Nematode, Caenorhabditis Elegans: a Review
Journal of Zoological Research Volume 3, Issue 4, 2019, PP 19-30 ISSN 2637-5575 Applications of the Free-Living Nematode, Caenorhabditis Elegans: A Review Marwa I. Saad El-Din* Assistant Professor, Zoology Department, Faculty of Science, Suez Canal University, Egypt *Corresponding Author: Marwa I. Saad El-Din, Assistant Professor, Zoology Department, Faculty of Science, Suez Canal University, Egypt. Email: [email protected]. ABSTRACT The free-living nematode, Caenorhabditis elegans, has been suggested as an excellent model organism in ecotoxicological studies. It is a saprophytic nematode species that inhabits soil and leaf-litter environments in many parts of the world. It has emerged to be an important experimental model in a broad range of areas including neuroscience, developmental biology, molecular biology, genetics, and biomedical science. Characteristics of this animal model that have contributed to its success include its genetic manipulability, invariant and fully described developmental program, well-characterized genome, ease of culture and maintenance, short and prolific life cycle, and small and transparent body. These features have led to an increasing use of C. elegans for environmental toxicology and ecotoxicology studies since the late 1990s. Although generally considered a soil organism, it lives in the interstitial water between soil particles and can be easily cultured in aquatic medium within the laboratory. It has been successfully used to study toxicity of a broad range of environmental toxicants using both lethal and sub lethal endpoints including behavior, growth and reproduction and feeding. In this work we review the choice, use and applications of this worm as an experimental organism for biological and biomedical researches that began in the 1960s.
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Conferring of Degrees
ONE HUNDRED AND TWELFTH YEAR two thousand and eighteen Conferring of Degrees MAY 27 AND JUNE 10 LOMA LINDA, CALIFORNIA Message from the President Congratulations to the Class of 2018. One of the greatest joys experienced by our campus community is the opportunity to celebrate your academic excellence and personal achievements. This 112th commencement season marks the culmination of your study and professional preparation, which has equipped you to meet the next great adventures of your lives. You and those who have supported you are to be commended. Now and for all time, you occupy a place among the alumni of this historic institution. I urge you always to model in your personal and professional life the excellence and vision, the courage and resilience, the passion and compassion that continue to shape and enhance our global reputation and legacy. As you move beyond this weekend to the world of work or the pursuit of advanced degrees, I know that your commitment to our mission and values will be evident as your knowledge and skills are used to “continue the teaching and healing ministry of Jesus Christ—to make man whole.” Now go with confidence wherever your dreams may lead you—questioning, learning, and challenging as you change our world for the better. I wish for you a satisfying and successful journey as you serve in the name and spirit of our gracious God. Richard H. Hart, M.D., Dr.P.H. 1 Contents Message from the President 1 2018 Events of Commencement 3 The Academic Procession 5 Significance of Academic Regalia 7 The Good Samaritan
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From the President's Desk
JAN - FEB 2008 From the President’s desk: The Urbilateria Book Project Genetics is thriving as never before, spawning in recent years sub- disciplines such as genomics, bioinformatics, evo-devo, systems biology, and more. If genetics were a business, there would be much talk about its growing market share both in basic science, its traditional realm, and increasingly throughout the world of medicine (with significant upside potential). The ageless questions – how genomes evolved on Earth, how genotype programs phenotype, what makes each of us human but unique, how genetic knowledge can better our lives – suddenly seem less daunting, more like practical tasks. Unsurprisingly, some of the brightest young minds on the planet are striving to join this remarkable enterprise in what promises to be among its greatest years. The Genetics Society of America should be at the forefront of all these developments. Genetic advances continue to unify all biological sciences, and a forum is needed to provide wise counsel, to nurture the careers of young geneticists, to communicate with the public, and to improve education, so more individuals can bring a true understanding of the biological world to today’s issues. There are several steps the GSA must take to provide this needed leadership. First, we must reach out and welcome every person who works to understand how genomes operate. We not only want a diverse membership, we need one. Splintering may succeed within ecosystems, but a tropical rainforest of genetics will not advance the future of our science, which is striving for unification. Most of the time we will continue to revel in our favorite realms, but we need a Genetics Society capable of overseeing the full scope of genetic science placing it all in its proper perspective.
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Caenorhabditis Elegans Meets Microsporidia: the Nematode Killers from Paris Jonathan Hodgkin*, Frederick A
Primer Caenorhabditis elegans Meets Microsporidia: The Nematode Killers from Paris Jonathan Hodgkin*, Frederick A. Partridge ntracellular invasion is a great strategy for a microbial cell biology. It may also provide a convenient means of pathogen. By colonizing the cytoplasm or an exploring microsporidian biology, much of which is still Iintracellular compartment, the pathogen is shielded mysterious. from many host defenses and gains privileged access to cellular nutrients. Intracellular pathogens are familiar The Nematode as a Model Host in mammalian systems, in the form of bacteria such as C. elegans has become an increasingly popular host for Mycobacterium [1] and Listeria [2], and eukaryotic parasites studying pathogenesis [11], following in the steps of such as Leishmania [3] and Trypanosoma cruzi [4]. The Drosophila as a system for investigating conserved or novel mechanisms whereby they get into cells and survive and innate immune mechanisms [12]. It is an established model multiply within them are central to their pathogenicity. organism, with numerous technical advantages, one of which Also, such pathogens often subvert host cellular machinery is the simplicity of growing worms by feeding them with in interesting and informative ways. For example, the ability bacteria on agar plates. This lends itself to studying the effects of Listeria cells to make “comet tails” of actin in order to of known pathogens, which can easily be tested for effects propel themselves around cells has provided useful tools for on the worm by exposing the worms to a lawn of the relevant investigating actin-based movement [5]. bacterium [13,14]. Many bacterial and fungal species have The invasion strategy is evidently ancient, and occurs even now been shown to have toxic or pathogenic effects on the within bacteria themselves, in the form of bdellovibrios, worm (Figure 1).
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Investigation of Meiotic Defects in Male Infertility by He Ren B.Sc., The
Investigation of Meiotic Defects in Male Infertility by He Ren B.Sc., The University of British Columbia, 2013 A THESIS SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE in THE FACULTY OF GRADUATE AND POSTGRADUATE STUDIES (Reproductive and Developmental Sciences) THE UNIVERSITY OF BRITISH COLUMBIA (Vancouver) August 2016 © He Ren, 2016 ABSTRACT Formation of the synaptonemal complex (synapsis), and crossing over of DNA (recombination) is important for chromosome segregation during meiosis. However, reduced rates of recombination have been observed in infertile men. Our previous study linked decreased recombination on sex chromosomes to increased XY disomy in sperm. This finding elicited our interest in the relationship between autosomal recombination and sperm disomy. We hypothesize that a lack of recombination on smaller chromosomes (21, X and Y) may most likely lead to aneuploid sperm. Using immunofluorescence, and fluorescent in situ hybridization, we examined synaptic errors, recombination, and sperm aneuploidy in infertile, and fertile men. When all infertile men were pooled, the frequency of recombination on sex chromosomes and bivalent 21 negatively correlated to rates of corresponding sperm disomy. Our unprecedented finding suggest that meiotic defects may indeed be leading to infertility, and increasing sperm aneuploidy. Moreover, we previously showed changes in crossover distribution in some infertile men. In this thesis, we examined whether this population display specific crossover distributions that may cause chromosome missegregation. Using FISH, we analyzed chromosome-specific crossover distributions, discovering that some infertile men had increased crossovers in regions where they are normally inhibited, which may disrupt structural proteins involved in segregation. We were also interested in the mechanisms behind meiotic defects, and hence studied telomere homeostasis in infertile men.
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Natural Variation in a Neuropeptide Y Receptor Homolog Modifies Social Behavior and Food Response in C
Cell, Vol. 94, 679±689, September 4, 1998, Copyright 1998 by Cell Press Natural Variation in a Neuropeptide Y Receptor Homolog Modifies Social Behavior and Food Response in C. elegans Mario de Bono* and Cornelia I. Bargmann natural heterogeneity. Indeed, studies of foraging be- Howard Hughes Medical Institute havior and circadian rhythms in wild Drosophila strains Programs in Developmental Biology, Neuroscience, have revealed genes that contribute to natural variation and Genetics in these responses (Osborne et al., 1997; Sawyer et al., Departments of Anatomy and Biochemistry & 1997). This approach is also being taken to map natural Biophysics behavioral differences in inbred mice (Melo et al., 1996; The University of California Finley et al., 1997; Wehner et al., 1997) and genetic San Francisco, California 94143-0452 influences on human behavior (Brunner et al., 1993; Kar- ayiorgou et al., 1997). The nematode C. elegans is a good organism in which Summary to study natural variation in behavior because of its simple nervous system, powerful genetics, and the avail- Natural isolates of C. elegans exhibit either solitary or ability of many wild strains isolated from different parts social feeding behavior. Solitary foragers move slowly of the world (Hodgkin and Doniach, 1997; Bargmann and on a bacterial lawn and disperse across it, while social Kaplan, 1998). Here, we investigate genetic variability foragers move rapidly on bacteria and aggregate to- in a social feeding behavior of C. elegans. Wild-type gether. A loss-of-function mutation in the npr-1 gene, hermaphrodites from the laboratory strain N2 are soli- which encodes a predicted G protein±coupled recep- tary in plentiful food; they aggregate into swarms or tor similar to neuropeptide Y receptors, causes a soli- clumps when food is limiting but disperse when food tary strain to take on social behavior.
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