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Sten Grillner
BK-SFN-HON_V9-160105-Grillner.indd 108 5/6/2016 4:11:20 PM Sten Grillner BORN: Stockholm, Sweden June 14, 1941 EDUCATION: University of Göteborg, Sweden, Med. Candidate (1962) University of Göteborg, Sweden, Dr. of Medicine, PhD (1969) Academy of Science, Moscow, Visiting Scientist (1971) APPOINTMENTS: Docent in Physiology, Medical Faculty, University of Göteborg (1969–1975) Professor, Department of Physiology III, Karolinska Institute (1975–1986) Director, Nobel Institute for Neurophysiology, Karolinska Institute, Professor (1987) Nobel Committee for Physiology or Medicine, Chair, 1995–1997 (1987–1998) Nobel Assembly at the Karolinska Institutet, Member Chair, 2005 (1988–2008) Chairman Department of Neuroscience, Karolinska Institutet (1993–2000) Distinguished Professor, Karolinska Institutet (2010) HONORS AND AWARDS: Member of Academiae Europaea 1990– Member of Royal Swedish Academy of Science 1993– Chairman Section for Biology and Member of Academy Board, 2004–2010 Member of Norwegian Academy of Science and Letters, 1997– Member American Academy of Arts and Sciences, 2004– Honorary Member of the Spanish Medical Academy, 2006– Foreign Associate of Institute of Medicine of the National Academy, United States, 2006– Foreign Associate of the National Academy, United States, 2010– Associate of the Neuroscience Institute, La Jolla, 1989– Member EMBO, 2014– Florman Award, Royal Swedish Academy of Science, 1977 Grass Lecturer to the Society of Neuroscience, Boston, 1983 Greater Nordic Prize of Eric Fernstrom, Lund, Sweden, 1990 Bristol-Myers -
Science & Policy Meeting Jennifer Lippincott-Schwartz Science in The
SUMMER 2014 ISSUE 27 encounters page 9 Science in the desert EMBO | EMBL Anniversary Science & Policy Meeting pageS 2 – 3 ANNIVERSARY TH page 8 Interview Jennifer E M B O 50 Lippincott-Schwartz H ©NI Membership expansion EMBO News New funding for senior postdoctoral In perspective Georgina Ferry’s enlarges its membership into evolution, researchers. EMBO Advanced Fellowships book tells the story of the growth and ecology and neurosciences on the offer an additional two years of financial expansion of EMBO since 1964. occasion of its 50th anniversary. support to former and current EMBO Fellows. PAGES 4 – 6 PAGE 11 PAGES 16 www.embo.org HIGHLIGHTS FROM THE EMBO|EMBL ANNIVERSARY SCIENCE AND POLICY MEETING transmissible cancer: the Tasmanian devil facial Science meets policy and politics tumour disease and the canine transmissible venereal tumour. After a ceremony to unveil the 2014 marks the 50th anniversary of EMBO, the 45th anniversary of the ScienceTree (see box), an oak tree planted in soil European Molecular Biology Conference (EMBC), the organization of obtained from countries throughout the European member states who fund EMBO, and the 40th anniversary of the European Union to symbolize the importance of European integration, representatives from the govern- Molecular Biology Laboratory (EMBL). EMBO, EMBC, and EMBL recently ments of France, Luxembourg, Malta, Spain combined their efforts to put together a joint event at the EMBL Advanced and Switzerland took part in a panel discussion Training Centre in Heidelberg, Germany, on 2 and 3 July 2014. The moderated by Marja Makarow, Vice President for Research of the Academy of Finland. -
Medicine@Yale U
@ MedicineAdvancing Biomedical Science, Education and Health Care YaleVolume 4, Issue 3 July/August 2008 Leading scientist is appointed new chair of Cell Biology Membrane traffi c expert and chair of the School of Medicine’s to Yale’s recently protein-coding genes in the human Department of Cell Biology. Roth- opened West Cam- genome, providing fresh insights into will head a department man will come to Yale from Columbia pus in West Haven, disease and new molecular targets for that has shaped the fi eld University’s College of Physicians and Conn., where he will therapy. Under Rothman’s leadership Surgeons, where he is now a professor launch a Center for the Department of Cell Biology will James E. Rothman, F>:, one of the in the Department of Physiology and High-Throughput be signifi cantly expanded, and will be world’s foremost experts on mem- Biophysics, the Clyde and Helen Wu Cell Biology. At the co-located at the West Campus along brane traffi cking, the means by which Professor of Chemical Biology and new center, multi- with its present location at the main proteins and other materials are director of the Columbia Genome +BNFT3PUINBO disciplinary teams campus of the School of Medicine. transported within and between cells, Center. of scientists will develop tools and For his decades of seminal re- has been named the Fergus F. Wal- In addition to directing Cell techniques to rapidly decipher the cel- search on the transport of molecules lace Professor of Biomedical Sciences Biology, Rothman is the fi rst recruit lular functions of the -
The Kavli Prize Laureate Lecture
The Kavli Prize Laureate Lecture 24 April 2013, 17:00 – 20:00 The Nordic Embassies in Berlin, Rauchstraße 1, 10787 Berlin-Tiergarten In co-operation with: Berlinffff The Kavli Prize is a partnership between The Norwegian Academy of Science and Letters, The Kavli Foundation and The Norwegian Ministry of Education and Research Programme: 16:30 Registration Please be seated by 16:55 17:00 Welcome Sven E. Svedman, Norwegian Ambassador to Germany 17:05 ”The Kavli Prize: fostering scientific excellence and international cooperation” Ms Kristin Halvorsen, Norwegian Minister of Education and Research 17:20 „Internationale Herausforderungen – internationale Kooperationen: Der Auftrag der Wissenschaft“ Prof. Dr. Johanna Wanka, Federal Minister of Education and Research 17:35 Short remarks Prof. Dr. Herbert Jäckle, Vice President of the Max Planck Society 17:40 Short remarks Professor Kirsti Strøm Bull President of The Norwegian Academy of Science and Letters 17:45 Lecture: “Following the Brain’s Wires” Kavli Prize Laureate Prof. Dr. Winfried Denk Max Planck Institute for Medical Research, Heidelberg 18:10 Lecture: “Towards an Understanding of Neural Codes” Prof. Dr. Gilles Laurent Director of the Max Planck Institute for Brain Research, Frankfurt 18:35 Reception Exhibition Hall of the Nordic Embassies in Berlin “Following the Brain’s Wires” Kavli Prize Laureate Prof. Dr. Winfried Denk To understand neural circuits we need to know how neurons are connected. Over the past decade we have developed methods that allow the reconstruction of neural wiring diagrams via the acquisition and analysis of high-resolution three-dimensional electron microscopic data. We have applied these methods to the retina in order to explore, for example, how direction-selective signals are computed. -
Neuroscience at the University of Warwick
b a n e w s l e t t e r f o r m e m b e r s o f t h e B N A 9 5 e Thalamostriatal u s s projections I revisited: new 8 0 u 0 questions and 2 answers N M U T U A / l R E l M M e U S t i n I N S I D E Secretary’s Report 3 Opinion 4 Spotlight on FENS Schools 5-6 BNA News 7-11 BNA Events 12-14 Scientific Review 15-17 Focus on Neuroscience: Warwick University 18-21 Science and Communication 22-25 Science and Society 26-28 Meeting Reports 29-35 M A R G N I N Bulletin I L SECRETARY’S REPORT O C G The sixth FENS Forum in Geneva (12-16 July) proved again BNA has been co-hosts of two of the three awards. The first of to be a great success. This event continues to be Europe’s these on ‘The Future of the Restorative Neurosciences in Stroke largest neuroscience event – over 5000 registered, including Rehabilitation’ was coordinated by Richard Greenwood and nearly 500 from the UK alone, exceeding the numbers that John Rothwell (Institute of Neurology) and held last September. attended in Vienna in 2006. An exciting programme delivered The second, which was coordinated by Kevin Talbot (Oxford) nine plenary lectures, 11 special lectures, 56 symposia, about and Ammar Al-Chalabi (King’s College, London), addressed 3500 posters and 240 oral presentations – surely enough to ‘Controversies in Motor Neuron Disease Research and Practice’ have satisfied everyone’s scientific appetite. -
The Kavli Prize Inaugural Symposium on Neuroscience
Neuroscience 163 (2009) 965–976 MOLECULAR APPROACHES TO UNDERSTANDING NEURAL NETWORK PLASTICITY AND MEMORY: THE KAVLI PRIZE INAUGURAL SYMPOSIUM ON NEUROSCIENCE M. SANDER,a L. H. BERGERSENb AND cal markers, biological transport, biophysics, calcium signaling, J. STORM-MATHISENb* central nervous system, cerebellum, computer simulation, condition- aPage One Editorial Services, 685 Poplar Avenue, Boulder CO 80304, ing (classical), crustacea, crystallography (X-Ray), cytoskeletal pro- USA teins, dendritic spines, discrimination learning, electric stimulation, electrophysiology, excitatory amino acid antagonists, excitatory bDepartment of Anatomy, Institute of Basic Medical Sciences, and Centre postsynaptic potentials, fear, ganglia (invertebrate), gene expres- for Molecular Biology and Neuroscience, University of Oslo, PO Box 1105 sion, glutamates, glutamic acid, green fluorescent proteins, humans, Blindern, 0317 Oslo, Norway immunohistochemistry, kinetics, learning, leucine, ligands, maze learning, membrane potentials, membrane transport proteins, mice, Abstract—The Kavli Prizes were awarded for the first time in mice (knockout), mice (transgenic), microscopy (confocal), micros- Oslo, Norway on September 9, 2008 to seven of the world’s copy (immunoelectron), models (neurological), motor activity, motor most prominent scientists in astrophysics, nanoscience and neurons, nerve tissue proteins, neural conduction, neuronal plastic- neuroscience. The astrophysics prize was awarded jointly to ity, neurotransmitter agents, neurotransmitter transport -
CURRICULUM VITAE for STEN GRILLNER
CURRICULUM VITAE for STEN GRILLNER ACADEMIC TRAINING Med cand. (1962), Dr of Medicine - PhD in Neurophysiology, Göteborg (1969), University of Göteborg, Visiting Scientist, Academy of Science Moscow (1971, 5mo). APPOINTMENTS 2010 - Distinguished professor Karolinska institute 1987-present Nobel Institute for Neurophysiology, Karolinska Institute, Professor and Director 1996-2006 Chairman Network program for Neuroscience/Psychiatry at KI 1993-2000 Department of Neuroscience, Karolinska Institutet, Chairman 1975-1986 Department of Physiology III, Karolinska Institute, Professor 1973-1975 eo Docent in Physiology, Medical Faculty Gothenburg 1969 Docent in Physiology 1988-2008 Nobel Assembly at the Karolinska Institutet, Member, Deputy chair 2004, chairman 2005 1987-1997 Nobel Committee for Physiology or Medicine, adj. or full member 1995-1997 Nobel Committee, Chairman, (Deputy chair 1992-1994). ACADEMIES Member of Academiae Europaeae 1990- Member of Royal Swedish Academy of Science 1993- Chairman Section for Biology & member of Gov. Board of RSAS 2004-2010 Member of Norwegian Academy of Science and Letters 1997- Member American Academy of Arts and Sciences 2004- Honorary member of the Spanish Medical Academy 2006- Member Institute of Medicine of the National Academy, USA 2006- Member of the National Academy, USA 2010- Associate of the Neuroscience Institute, La Jolla 1989- Member of Rodin Remediation Academy, member of council (1997) 1988- AWARDS Florman award, Royal Swedish Academy of Science 1977 Grass lecturer to the Society of Neuroscience, -
EMBO Facts & Figures
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Annual Report 2013 Annual Report Annual Report 2013 Kavli Institute for Systems Neuroscience and Centre for Neural Computation
Kavli Institute for Systems Neuroscience and Centre for Neural Computation Annual Report 2013 Annual Report Annual report 2013 Kavli Institute for Systems Neuroscience and Centre for Neural Computation The people at KI/CNC March 2014. (Photo: Thor Nielsen) Facts about KI /CNC May-Britt and Edvard Moser established the Laboratory for Memory Studies at the Norwegian University of Science and Technology (NTNU) in Trondheim in 1996. In 2002, a ten-year-long grant from the Research Council of Norway enabled the laboratory to expand to become a Centre of Excellence (CoE). The new institution was named the Centre for the Biology of Memory (CBM), with Edvard Moser as director and May-Britt Moser as co-director. In 2007, the Norwegian-American physicist, businessman, billionaire and philanthropist Fred Kavli selected the CBM as one of 15 prestigious Kavli Institutes worldwide. The centre accordingly changed its name to the Kavli Institute for Systems Neuroscience and the Centre for the Biology of Memory (KI/CBM). The first CoE period expired in 2012, but the Research Council of Norway decided at the same time that the Trondheim research group should be awarded new funding. At the end of 2012-2013 the centre changed its name to the Kavli Institute for Systems Neuroscience and the Centre for Neural Computation (KI/CNC). The Kavli Institute is led by Edvard Moser, while the CNC is led by May-Britt Moser. KI/CNC is part of the Norwegian Brain Centre at NTNU, and contains perhaps the largest infrastructure for systems neurophysiology in the world. The centre’s basic research approach has always been to understand the sense of location as a model for developing a deeper understanding of memory and the workings of the brain. -
FIRST NORDIC NEUROSCIENCE MEETING a Scientific Meeting for All Neuroscientists Arranged in Trondheim, Norway
The Nordic Neuroscience 2015 JUNE 10-12, 2015 CONFERENCE BOOK FIRST NORDIC NEUROSCIENCE MEETING A scientific meeting for all neuroscientists arranged in Trondheim, Norway. A wish of achieving greater knowledge about the work done in Nordic institutes to open more interactions with neighboring countries and establish networks for future collaborations. 2 THE NORDIC NEUROSCIENCE 2015 JUNE 10-12 IN TRONDHEIM, NORWAY We are delighted to welcome you to the first-ever gathering of Nordic Neuroscience, held in the city of Trondheim, Norway. This is a newly initiated conference with the goal of increasing our interaction with neighbouring countries and establishing networks for future collaboration. Our wish is simple and unambiguous: we want to increase our collective knowledge about the work being conducted at Nordic and Baltic institutes. As the first event of this kind, we hope that speakers, poster presenters, participants and exhibitors will come away from the conference with the feeling they have met with success. We also have the larger ambition that this first conference in Trondheim will create a strong platform for the concept, so our goal of arranging this event biannually in various Nordic locations become a reality. The programme committee has worked on the conference since the autumn of 2013. Members have met in Trondheim to look at locations and discuss the programme’s composition. The result, we believe, is a stong line-up of excellent symposium speakers from Nordic institutes and top international plenary speakers from whom we hope you learn, are motivated by and enjoy. The programme committee also believes poster presentations are an essential aspect of the conference, and it is with great pleasure that we acknowledge the many individuals who have offered to present their work. -
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The Journal of Neuroscience, December 1991, 1 I(1 2): 37183726 The Involvement of GABA, Receptors and Coupled G-Proteins in Spinal GABAergic Presynaptic Inhibition Simon Alford” and Sten Grillner Nobel institute for Neurophysiology, Karolinska Institutet, S 104 01 Stockholm, Sweden GABA acts as a presynaptic inhibitory transmitter in the spi- and postsynaptic structures (Curtis et al., 1968, 1977). Synaptic nal cord. In the lamprey, it has recently been shown that it release is reduced, after activation of GABA, receptors, from acts in this way at both primary sensory and motor system primary afferents in the mammalian spinal cord (Curtis et al., synapses and is important in the generation of a locomotor 198 1) and lamprey spinal cord (Christenson and Grillner, 199 1) rhythm. Both GABA, and GABA, receptors are activated at as well as onto pyramidal neurons of the hippocampus (Bowery these sites by GABA released during physiological activity. et al., 1980; Lanthom and Cotman, 1981; Ault and Nadler, In some systems, GABA, receptor activation has been shown 1982). In the lamprey, it has also been demonstrated that the to lead to modulation of ion channel function indirectly through spinal motor system utilizes presynaptically directed GABAer- the action of a pertussis toxin (PTX)-sensitive G-protein. gic transmission, that both GABA, and GABA, receptor sub- Here we have studied the mechanism of action of the pre- types coexist on spinal axons, and that GABAergic transmission synaptic GABA, receptor in this system. GABA, receptor is of importance in the generation of locomotor activity (Alford activation leads to a decrease in axonal membrane imped- et al., 1990, 1991). -
INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE Brain & Spine Institute - PARIS
INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE Brain & Spine institute - PARIS SEARCH, FIND, CURE, FOR YOU & WITH YOU P 4 - EDITORIALS P 7 - ORGANIZATION OF RESEARCH AT THE ICM P 15 - 2014 in REview P 17 - RESEARCH P 59 - THE IHU-A-ICM P 69 - TECHNICAL PLATFORMS P 97 - THE CLINICAL INvESTIGATION CENTER P 105 - RESEARCH APPLICATIONS TABLE OF CONTENTS OF TABLE P 109 - KEY FIGURES P 117 - LIFE AT THE ICM P 125 - GOvERNANCE, OvERSIGHT, AND TRANSPARENCY Introductory Présentation remarks des équipes by the Presidentde l’Institut and Director-General of the ICM Presentation of the teams of the institute 1 - Neurodegenerative diseases 2 - Multiple sclerosis 1 3 - Brain tumors 4 - Epilepsies 5 - Cognition, behavior, and psychiatric diseases 6 - Modeling 7 - Rare diseases 8 - Basic mechanisms underlying the development and function of the nervous system Glossary 1 - Major achievements 2 - Major publications 2 1 - Molecular exploration 2 - Cellular exploration 3 - Cellular imaging 3 4 - Functional exploration 5 - Preclinical functional exploration- phenoparc 6 - Bioinformatics and biostatistics – iconics 7 - Biological Resource Center 1 - Parkinson’s Disease 2 - Neurogenetics 4 3 - Alzheimer’s Diseases 4 - Multiple sclerosis 5 - Amyotrophic lateral sclerosis 6 - Rare diseases 7 - Understand brain function: motivation 8 - Participatory medicine 1 - Transform knowledge and promote research 2 - iPEPS-ICM companies 5 1 - Fundraising 2 - Use of Resources Statement 6 3 - Balance sheet 1 -Scientific and extra-scientific events 7 2 -Publicity campaigns 1 -Governance and oversight: Board of Administration, Founding Members, Scientific Council,Comité de la charte 8 2 -Friends of the ICM Circle EDITORIAL Hope. It’s the key word for 2014, thanks to the This year, the first international companies arrived at enthusiasm and achievements of our researchers and the ICM: Neoventure Technologies (Ontario), which our partners, growing in numbers by our side.